AdditionalResources

Confusion

END YOUR CHOLESTEROL

ADDITIONAL RESOURCES

The resources listed here will give you additional information about each of the

topics covered in the End Your Cholesterol Confusion Masterclass.

We have provided recommendations appropriate for the general public as well as

some that are better suited for medical and nutrition/dietetics professionals. If you

are not a professional but are science-minded or have a solid background and

working knowledge of human physiology and biochemistry, you will likely find the

more scientific resources to be educational and compelling.

FOR THE GENERAL PUBLIC

CV Risk Calculator:

● http://www.cvriskcalculator.com/

Books

Specifically about cholesterol and cardiovascular disease:

● Cholesterol Clarity, by Jimmy Moore and Eric Westman, MD

● The Great Cholesterol Myth, by Jonny Bowden and Stephen Sinatra, MD

● The Great Cholesterol Con, by Malcolm Kendrick, MD

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About the science, politics, and history of how the cholesterol-centric paradigmand negative view on saturated fats came to be:

● The Big Fat Surprise, by Nina Teicholz

● Good Calories, Bad Calories, by Gary Taubes

About the effects of excess dietary sugar & starch, and the health-promotingeffects of low-carbohydrate diets:

● The Art and Science of Low Carbohydrate Living, by Jeff Volek, PhD, RD and

Stephen Phinney, MD, PhD

● End Your Carb Confusion, by Eric C. Westman, MD and Amy Berger

● Pure, White, and Deadly, by John Yudkin, MD

● The Saccharine Disease, by TL Cleave, MD

Videos

● The Lipid Energy Model, by Dave Feldman. (Presentation delivered to

Stanford University students, by invitation, April 2020.)

https://youtu.be/ewc7VvbkTTg

● Cholesterol, LDL & Statins, by David Diamond, PhD. (Presentation delivered

at Low Carb Houston, October 2019.) https://youtu.be/i6za3BYF3e4

● A Deep Dive into Cholesterol and Risk, by Dave Feldman. (Presentation

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delivered at Keto Salt Lake, April 2019.) https://youtu.be/UZv00mMiB9M

● Incredible Changes in LDL Cholesterol Through a Simple Diet Experiment,

by Dave Feldman. (January 2018.) https://youtu.be/lYVRKtoRpQk

● Basic overview of the coronary artery calcium scan:

https://youtu.be/es7KGt48iG8

FOR MEDICAL & NUTRITION PROFESSIONALS

Mayo Clinic Statin Decision Aid:

● https://statindecisionaid.mayoclinic.org/

Books

● The Cholesterol Myths, by Uffe Ravnskov. New Trends Publishing, Inc. (2003).

● Fat and Cholesterol Don't Cause Heart Attacks and Statins are Not the Solution.Paul Rosch, MD, Editor. Columbus Publishing Ltd (2016).

● Lipid Lunacy: Diet delusions and what really causes heart disease. Paul J. Rosch,

MD and Abdullah Alabdulgader, MD, editors. Columbus Publishing Ltd

(2020).

● Diabetes Epidemic & You, by Joseph Kraft, MD. Trafford Publishing (2008).

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Videos

● Cholesterol, LDL & Statins, by David Diamond, PhD. (Presentation delivered

at Low Carb Houston, October 2019.) https://youtu.be/i6za3BYF3e4

● Do statins prevent or cause heart disease? Should LDL be called "bad"

Cholesterol? by Nadir Ali, MD. (Presentation delivered at Low Carb Denver,

2020.) https://youtu.be/o_QdNX9etCg

● The Lipid Energy Model, by Dave Feldman. (Presentation delivered to

Stanford University students by invitation, April 2020.)

https://youtu.be/ewc7VvbkTTg

● Why LDL cholesterol goes up with a low-carb diet and is it bad for health? By

Nadir Ali, MD. (Presentation delivered at Low Carb Denver 2019.)

https://youtu.be/qXtdp4BNyOg

● Statin Wars: Have we been misled by the evidence? By Maryanne Demasi,

PhD. (Presentation delivered at Low Carb Down Under, May 2018.)

https://youtu.be/BzTjPuikhQE

● Insulin resistance and ApoE4 - A Perfect Storm, by Nadir Ali, MD.

(Presentation delivered at Low Carb Denver, 2020.)

https://youtu.be/A78RxVZnXgI

● Incredible Changes in LDL Cholesterol Through a Simple Diet Experiment,

by Dave Feldman. (January 2018.) https://youtu.be/lYVRKtoRpQk

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Scientific Papers

Cholesterol in general and LDL, in particular:

● Ravnskov U, de Lorgeril M, Diamond DM, Hama R, Hamazaki T,

Hammarskjöld B, Hynes N, Kendrick M, Langsjoen PH, Mascitelli L, McCully

KS, Okuyama H, Rosch PJ, Schersten T, Sultan S, Sundberg R. LDL-C does not

cause cardiovascular disease: a comprehensive review of the current

literature. Expert Rev Clin Pharmacol. 2018 Oct;11(10):959-970.

● Reaven GM. Looking at the world through LDL-cholesterol-colored glasses. J

Nutr. 1986 Jul;116(7):1143-7. doi: 10.1093/jn/116.7.1143.

● Ravnskov U, Diamond DM, Hama R, et al. Lack of an association or an inverse

association between low-density-lipoprotein cholesterol and mortality in

the elderly: a systematic review. BMJ Open. 2016;6(6):e010401.

● DuBroff R, Malhotra A, de Lorgeril M. Hit or miss: the new cholesterol

targets. BMJ Evid Based Med. 2020 Aug 3:bmjebm-2020-111413. doi:

10.1136/bmjebm-2020-111413.

● Norwitz NG, Loh V. A Standard Lipid Panel Is Insufficient for the Care of a

Patient on a High-Fat, Low-Carbohydrate Ketogenic Diet. Front Med

(Lausanne). 2020;7:97. Published 2020 Apr 15.

doi:10.3389/fmed.2020.00097.

Utility of the coronary artery calcium (CAC) scan in identifying “high” and “low”risk patients independent of LDL-C:

● Bittencourt MS, Nasir K, Santos RD, Al-Mallah MH. Very high LDL

cholesterol: The power of zero passes another test. Atherosclerosis. 2020

Jan;292:207-208. doi: 10.1016/j.atherosclerosis.2019.11.019.

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● Han D, Ó Hartaigh B, Lee JH, et al. Assessment of Coronary Artery Calcium

Scoring for Statin Treatment Strategy according to ACC/AHA Guidelines in

Asymptomatic Korean Adults. Yonsei Med J. 2017;58(1):82-89.

doi:10.3349/ymj.2017.58.1.82

● Nasir K, Bittencourt MS, Blaha MJ, Blankstein R, Agatson AS, Rivera JJ,

Miedema MD, Sibley CT, Shaw LJ, Blumenthal RS, Budoff MJ, Krumholz HM.

Implications of Coronary Artery Calcium Testing Among Statin Candidates

According to American College of Cardiology/American Heart Association

Cholesterol Management Guidelines: MESA (Multi-Ethnic Study of

Atherosclerosis). J Am Coll Cardiol. 2015 Oct 13;66(15):1657-68. doi:

10.1016/j.jacc.2015.07.066.

● Kavousi M, Desai CS, Ayers C, Blumenthal RS, Budoff MJ, Mahabadi AA,

Ikram MA, van der Lugt A, Hofman A, Erbel R, Khera A, Geisel MH, Jöckel

KH, Lehmann N, Hoffmann U, O'Donnell CJ, Massaro JM, Liu K, Möhlenkamp

S, Ning H, Franco OH, Greenland P. Prevalence and Prognostic Implications

of Coronary Artery Calcification in Low-Risk Women: A Meta-analysis.

JAMA. 2016 Nov 22;316(20):2126-2134. doi: 10.1001/jama.2016.17020.

Statin Drugs – clinical utility and potential problems:

● Okuyama H, Langsjoen PH, Hamazaki T, Ogushi Y, Hama R, Kobayashi T,

Uchino H. Statins stimulate atherosclerosis and heart failure:

pharmacological mechanisms. Expert Rev Clin Pharmacol. 2015

Mar;8(2):189-99.

● Redberg RF, Katz MH. Healthy men should not take statins. JAMA. 2012 Apr

11;307(14):1491-2. doi: 10.1001/jama.2012.423.

● Redberg RF, Katz MH. Statins for Primary Prevention: The Debate Is Intense,

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but the Data Are Weak. JAMA. 2016 Nov 15;316(19):1979-1981. doi:

10.1001/jama.2016.15085.

● Marshall TM. New Insights into the Statin-Cholesterol Controversy. Journal

of American Physicians and Surgeons. Vol 19 No 2; Summer 2014.

● Langsjoen PH, Langsjoen JO, Langsjoen AM, Rosenfeldt F. Statin-Associated

Cardiomyopathy Responds to Statin Withdrawal and Administration of

Coenzyme Q10. Perm J. 2019;23:18-257. doi:10.7812/TPP/18.257.

● U.S. Food & Drug Administration. FDA Drug Safety Communication:

Important safety label changes to cholesterol-lowering statin drugs.

(Includes acknowledgement that statin drugs may cause cognitive

impairment, higher blood sugar, and liver damage.) Document accessed

online Aug 24, 2021. (Content marked current as of Jan 2016.)

Familial hypercholesterolemia – LDL may not be the major issue:

● Ravnskov U, de Lorgeril M, Kendrick M, Diamond DM. Inborn coagulation

factors are more important cardiovascular risk factors than high

LDL-cholesterol in familial hypercholesterolemia. Med Hypotheses. 2018

Dec;121:60-63. doi: 10.1016/j.mehy.2018.09.019.

● Diamond DM, Alabdulgader AA, de Lorgeril M, Harcombe Z, Kendrick M,

Malhotra A, O'Neill B, Ravnskov U, Sultan S, Volek JS. Dietary

Recommendations for Familial Hypercholesterolaemia: an Evidence-Free

Zone. BMJ Evid Based Med. 2020 Jul 5: bmjebm-2020-111412. doi:

10.1136/bmjebm-2020-111412.

● Ravnskov U, de Lorgeril M, Kendrick M, Diamond DM. Serious flaws in

targeting LDL-C reduction in the management of cardiovascular disease in

familial hypercholesterolemia. Expert Rev Clin Pharmacol. 2021

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Mar;14(3):405-406. doi: 10.1080/17512433.2021.1889368.

Diet and cardiovascular disease:

A. Dietary saturated fat

● Lawrence GD. Dietary fats and health: dietary recommendations in the

context of scientific evidence. Adv Nutr. 2013;4(3):294-302.

doi:10.3945/an.113.003657.

● Siri-Tarino PW, Sun Q, Hu FB, Krauss RM. Meta-analysis of prospective

cohort studies evaluating the association of saturated fat with

cardiovascular disease. Am J Clin Nutr. 2010;91(3):535-546.

doi:10.3945/ajcn.2009.27725.

● Siri-Tarino PW, Sun Q, Hu FB, Krauss RM. Saturated fat, carbohydrate, and

cardiovascular disease. Am J Clin Nutr. 2010;91(3):502-509.

doi:10.3945/ajcn.2008.26285.

● Dehghan M, Mente A, Zhang X, Swaminathan S, Li W, et al., Prospective

Urban Rural Epidemiology (PURE) study investigators. Associations of fats

and carbohydrate intake with cardiovascular disease and mortality in 18

countries from five continents (PURE): a prospective cohort study. Lancet.

2017 Nov 4;390(10107):2050-2062. doi:

10.1016/S0140-6736(17)32252-3.

● Volek JS, Fernandez ML, Feinman RD, Phinney SD. Dietary carbohydrate

restriction induces a unique metabolic state positively affecting atherogenic

dyslipidemia, fatty acid partitioning, and metabolic syndrome. Prog Lipid

Res. 2008 Sep;47(5):307-18. doi: 10.1016/j.plipres.2008.02.003.

● Astrup A, Teicholz N, Magkos F, Bier DM, et al. Dietary Saturated Fats and

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Health: Are the U.S. Guidelines Evidence-Based? Nutrients. 2021;

13(10):3305. https://doi.org/10.3390/nu13103305.

● Diamond DM, O'Neill BJ, Volek JS. Low carbohydrate diet: are concerns with

saturated fat, lipids, and cardiovascular disease risk justified? Curr Opin

Endocrinol Diabetes Obes. 2020 Oct;27(5):291-300. doi:

10.1097/MED.0000000000000568.

● Noakes TD. Hiding unhealthy heart outcomes in a low-fat diet trial: the

Women's Health Initiative Randomized Controlled Dietary Modification

Trial finds that postmenopausal women with established coronary heart

disease were at increased risk of an adverse outcome if they consumed a

low-fat 'heart-healthy' diet. Open Heart. 2021;8(2):e001680.

doi:10.1136/openhrt-2021-001680.

● DiNicolantonio JJ, Lucan SC, O'Keefe JH. The Evidence for Saturated Fat and

for Sugar Related to Coronary Heart Disease. Prog Cardiovasc Dis.

2016;58(5):464-472. doi:10.1016/j.pcad.2015.11.006.

B. Metabolic syndrome (insulin resistance), type 2 diabetes, excess dietarycarbohydrate

● Reaven GM. Looking at the world through LDL-cholesterol-colored glasses. J

Nutr. 1986 Jul;116(7):1143-7. doi: 10.1093/jn/116.7.1143. PMID: 3528426.

● Reaven GM. Insulin resistance, the insulin resistance syndrome, and

cardiovascular disease. Panminerva Med. 2005 Dec;47(4):201-10.

● Weinberg SL. The diet-heart hypothesis: a critique. J Am Coll Cardiol. 2004

Mar 3;43(5):731-3. doi: 10.1016/j.jacc.2003.10.034.

● Staverosky T. Ketogenic Weight Loss: The Lowering of Insulin Levels Is the

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Sleeping Giant in Patient Care. J Med Pract Manage. 2016 Sep;32(1):63-66.

● Adeva-Andany MM, Martínez-Rodríguez J, González-Lucán M,

Fernández-Fernández C, Castro-Quintela E. Insulin resistance is a

cardiovascular risk factor in humans. Diabetes Metab Syndr. 2019

Mar-Apr;13(2):1449-1455. doi: 10.1016/j.dsx.2019.02.023.

● Kendall DM, Harmel AP. The metabolic syndrome, type 2 diabetes, and

cardiovascular disease: understanding the role of insulin resistance. Am J

Manag Care. 2002 Dec;8(20 Suppl):S635-53; quiz S654-7.

● Athinarayanan SJ, Hallberg SJ, McKenzie AL, et al. Impact of a 2-year trial of

nutritional ketosis on indices of cardiovascular disease risk in patients with

type 2 diabetes. Cardiovasc Diabetol. 2020;19(1):208.

● Bhanpuri NH, Hallberg SJ, Williams PT, et al. Cardiovascular disease risk

factor responses to a type 2 diabetes care model including nutritional ketosis

induced by sustained carbohydrate restriction at 1 year: an open label,

non-randomized, controlled study. Cardiovasc Diabetol. 2018;17(1):56.

● Yancy WS Jr, Olsen MK, Guyton JR, Bakst RP, Westman EC. A

low-carbohydrate, ketogenic diet versus a low-fat diet to treat obesity and

hyperlipidemia: a randomized, controlled trial. Ann Intern Med. 2004 May

18;140(10):769-77. doi: 10.7326/0003-4819-140-10-200405180-00006.

● O'Neill BJ. Effect of low-carbohydrate diets on cardiometabolic risk, insulin

resistance, and metabolic syndrome. Curr Opin Endocrinol Diabetes Obes.

2020 Oct;27(5):301-307. doi: 10.1097/MED.0000000000000569.

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Resources for finding medical and nutrition professionalswho are experienced with low-carbohydrate diets:

● The Society of Metabolic Health Practitioners: Find a practitioner

(https://thesmhp.org/membership-account/directory/)

● Diet Doctor: Find a doctor (https://www.dietdoctor.com/low-carb/doctors)

● Ketogenic.com: Doctor finder (https://ketogenic.com/doctors/)

● The Charlie Foundation (this listing includes registered dietitians who

specialize in rare diseases/disorders as well as weight loss, diabetes, etc.)

(https://charliefoundation.org/find-a-professional/)

The following medical professionals are licensed in severalUS states and provide online consultations and/or remotemonitoring:

● Nadir Ali, MD (cardiologist): https://alicardiology.com/

○ Virtual consultations: https://onlineconsultali.as.me/schedule.php

● Bret Scher, MD (cardiologist):

https://lowcarbcardiologist.com/about-dr-bret/

○ Virtual consultations:

https://lowcarbcardiologist.com/consult-with-dr-scher/

● Tro Kalayjian, MD (board certified in Obesity Medicine):

https://www.doctortro.com/

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Ordering lab tests privately:

We advise always working with your licensed medical professional to order lab

tests. However, should you wish to pursue private testing which you can then workwith your physician to assess and interpret, testing may be ordered through these

sites in the US:

● Direct Labs: https://www.directlabs.com/Default.aspx

● Own Your Labs: https://ownyourlabs.com/

● Quest Direct: https://questdirect.questdiagnostics.com/

(Please note that these may not be available in all US states.)

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