EndometriosisAn overview presentation of the work from the pain in

women research group – Nuffield department of women'sand reproductive health

Presented by Miriam Szabo, undergraduate medical student

What is Pain?

Chronic

Pain and Endometriosis

Chronic

Maladaptive

Giudice, 2010

Less pain More pain

Peripheral changes

Central changes in the CNS

Brain structural changes

Morotti M et al review (2014)

Brawn J et al review (2014)

S As-sanie et al (2012)

Hormonal changes

Katy Vincent and Irene Tracey (2008)

Strain and Barkley L Coxon (2018)

Psychological factors

L Coxon i2018, Sepulcri Rde P et al 2009

Cerebellum

S2

PAG

Thalamus

Insula

AMY

ACC

PFC

S1

Brainstem

The Brain and Chronic Pain

Changes in brain density in key areas

A.May (2011)

Observed in 14 chronic pain conditons