epic meeting on photonics for cancer diagnostics and...

EPIC Meeting on Photonics for Cancer Diagnostics and Treatment

11–12 December 2019 Amsterdam, The Netherlands

FUNDED BY

SILVER SPONSORS

HOSTED BY

BRONZE SPONSORS

The Netherlands Cancer InstituteThe Netherlands Cancer Institute is one of top 10 comprehensive cancercenters in Europe. Because treatment and research are placed under one roof,promising technologies can quickly find their way to the clinic; from bench tobedside.

To optimize this process, we have a large research infrastructure including aClinical Data Center and Trial Registration Office that can advise and assist withcomplying to national guidelines, medical ethical approval and data collection. Inaddition, our clinical implementation team with dedicated technical peopleimplements medical technology into daily clinical practice.

This makes us well equipped to participate in national as well as internationalprojects, such as Horizon 2020.

Contact: [email protected]

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Programme


The purpose of the EPIC Meeting on Photonics for Cancer Diagnostics and Treatment at NKI is facilitating

closure of the existing gap between unmet medical needs and innovative industrial solutions. The clinicians will

make a comprehensive overview of the existing requirements for cancer diagnostics and treatment with the

special emphasis on breast and prostate cancer. In turn, the companies will share their latest technological

advantages that are aiming to solve present issues. The developments focusing on the minimal invasive

diagnostic tools as well and interoperative tumor margin assessment such as Hyperspectral and Diffuse

reflectance imaging, Raman spectroscopy, OCT fluorescence imaging, etc. will be discussed alongside with

novel developments in the fields of the photodynamic therapy and other light-induces treatment solutions.

Wednesday 11 December 2019

11:30 – 12:30 Registration & Lunch @ NKI Address: Antoni van Leeuwenhoek Hospital, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam

12:30 – 12:35 Welcoming words Jose Pozo, CTO, EPIC

12:35 – 12:40 Welcoming words Theo Ruers, Oncological Surgeon, NKI

12:40 – 13:00 KEYNOTE: Future of healthcare Theo Ruers, Oncological Surgeon, NKI (THE NETHERLANDS)

SESSION 1 – CLINICAL NEEDS AND NEW TECHNOLOGIES FOR PROSTATE CANCER PART I 13:00 – 13:30 Clinical demands for intra-operative imaging in prostate cancer Henk van der Poel, Urologist, NKI (THE NETHERLANDS) 13:30 – 14:00 Optical diagnostics of l urinary tract cancer: towards real time finding and grading Daniel Martijn de Bruin, Group leader urological research, AUMC (THE NETHERLANDS) 14:00 – 14:30 Fluorescence Lifetime Imaging for Clinical Applications: Application to Trans-Oral Robotic Surgery Julien Bec, Engineering and Operations Director, University of California (USA) 14:30 – 15:00 Coffee break

SESSION 1 – CLINICAL NEEDS AND NEW TECHNOLOGIES FOR PROSTATE CANCER PART II

15:00 – 15:30 KEYNOTE: Imaging biopsies intact in 3D Pieter van der Zaag, Principal Scientist, Phillips (THE NETHERLANDS) 15:30 – 16:00 Clinical Raman Spectroscopy – beyond diagnosis Nicholas Stone, Professor of Biomedical Imaging and Biosensing, University of EXETER (UK)

16:00 – 16:30 Focal Laser Ablation of Localized Low and Intermediate Prostate Cancer: Early functional and oncological results Stefano Regusci, MD Urologist, Urorad and SIPC (SWITZERLAND) 16:30 – 17:00 Coffee break

SESSION 2 – PRE- AND INTRAOPERATIVE IMAGING OF BREAST CANCER 17:00 – 17:15 Clinical demands for intra-operative imaging in breast cancer Susan Brouwer de Koning, Technical Physician, NKI (THE NETHERLANDS) 17:15 – 17:45 Fiber optics in breast cancer Dick Sterenborg, Physicist, AUMC and NKI (THE NETHERLANDS) 17:45 – 18:15 Third Harmonic Generation Microscopy for Instant Pathology Marloes Groot, Professor, Vrije Universiteit Amsterdam (THE NETHERLANDS) 18:15 – 18:30 Ultra-sensitive Raman microscopy and endoscopy tools for pre- and intraoperative imaging Bodo Richter, CEO, APE (GERMANY) 18:45 – 19:30 Bus transfer from NKI to restaurant ‘t IJ in Van der Valk hotel Amsterdam – Amstel 19:30 – 23:00 Dinner @restaurant ‘t IJ Address: Joan Muyskenweg 20, 1096 CJ, Amsterdam 23:00 Bus transfer return to Corendon City hotel

Thursday 12 December 2019

07:30 – 08:00 Check-out from the hotel and walk to NKI

08:00 – 08:30 Morning networking coffee

08:30 – 08:40 Recap and introduction to the 2nd day Jose Pozo, CTO, EPIC

08:40 – 08:55 Emerging diagnostic imaging modalities in breast cancer Jacques Cochard, Business Development, Tematys (FRANCE)


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SESSION 3 – INDUSTRY PITCH PRESENTATIONS

08:55 – 09:00 Antje Haap-Hoff, Head of Clinical Applications, KARL STORZ (GERMANY)

09:00 – 09:05 Galit Ankri Eliahoo, Project Manager, OAL Innovations (ISRAEL)

09:05 – 09:10 Frank van Mourik, CTO, Femto diagnostics (THE NETHERLANDS)

09:10 – 09:15 Coenraad van Kalken, CEO, Qurin (THE NETHERLANDS)

09:15 – 09:20 Zoe Ylöniemi, Technical Sales Engineer, Modulight (FINLAND)

09:20 – 09:25 Jonatan Klee, Sales Manager, Ushio (THE NETHERLANDS)

09:25 – 09:30 Benno Oderkerk, CEO, Avantes (THE NETHERLANDS)

09:30 – 09:35 Gerwin Puppels, Managing Director, RiverD (THE NETHERLANDS)

09:35 – 09:40 Slava Artyushenko, President, art photonics (GERMANY)

09:40 – 09:45 Nicolas Lio Soon Shun, Business Development, CEA – Leti (FRANCE)

09:45 – 09:50 Christopher Phillips, Senior Research Scientist, ETH Zurich (SWITZERLAND)

09:50 – 09:55 David Heard, VP Sales, Santec (UNITED KINGDOM)

09:55 – 10:40 Coffee break

SESSION 4 – MULTIMODALITY OPTICAL IMAGING

10:40 – 11:10 Non-contact imaging for monitoring vital functions and diagnostics using ‘smart’ technologies Ruud Verdaasdonk, Professor, University of Twente (THE NETHERLANDS) 11:10 – 11:40 3D deep tissue imaging technologies for in-vivo diagnostics and digital pathology Stefan Andersson-Engels, Head of Biophotonics, Tyndall National Institute (IRELAND) 11:40 – 12:00 Development of ultra-fine needle endoscope for deep interstitial examination of breast, and preliminary results of breast cancer diagnostics by endoscopy autofluorescence imaging and raman spectroscopy Alexandre Douplik, Professor, Ryerson University (CANADA) and Alexandra Easson, Professor, University of Toronto (CANADA) 12:00 – 12:30 Multifunctional and targeted fluorescence OCT for tumor detection Johannes de Boer, Professor, Vrije Universiteit Amsterdam (THE NETHERLANDS) 12:30 – 14:00 Lunch

14:00 End & Optional bus transfer from NKI to Schiphol airport and train station CONTACTS

Helena Jelinkova, Events Manager, EPIC, mobile: +420 606 526252 Jose Pozo, CTO, EPIC, mobile: +31 626 978312 Elena Beletkaia, Project Leader, EPIC, mobile: +31 619 181296

Name Job Title Company Country Member

Alexandra Easson Surgeon Investigator University Health Network Canada

Alexandre Douplik Professor Ryerson University Canada

Almut Bailly Account Manager Chroma Technology Germany EPIC

Angelina Bogatzki Manager Product Engineering LEONI Fiber Optics Germany EPIC

Antje Haap-Hoff Head of Clinical Applications KARL STORZ Germany

Benno Oderkerk CEO Avantes The Netherlands EPIC

Bodo Richter CEO Angewandte Physik und Elektronik Germany EPIC

Christof Böhler Clinical Research & Diagnostics Prospective Instruments Austria EPIC

Christopher Phillips Senior Research Scientist ETH Zurich Switzerland EPIC

Coenraad van Kalken CEO Qurin Diagnostics The Netherlands

Dan Negrea Senior VP New Technologies AEMtec Germany EPIC

Daniel Martijn de Bruin Group Leader Urological Research Amsterdam UMC The Netherlands

Darine Abi Haidar Associate Professor IMNC laboratory France

David Heard VP Sales EMEA Santec Europe United Kingdom EPIC

Deepak Nair Product Line Specialist NKT Photonics Denmark EPIC

Dick Sterenborg Physicist AUMC, NKI The Netherlands EPIC

Didier Beghuin CTO Lambda-X Belgium EPIC

Dylan Burke Marketing Executive Yelo United Kingdom EPIC

Edlef Büttner Board Member Angewandte Physik und Elektronik Germany EPIC

Elad Volfin VP Sales & Business Development Monocrom Spain EPIC

Elena Beletkaia Project Leader EPIC The Netherlands EPIC

Frank van Mourik CTO Femto Diagnostics The Netherlands

Galit Ankri Eliahoo Project Manager OAL Innovations Israel EPIC

Georg Draude General Manager Chroma Technology Germany EPIC

Gerwin Puppels Managing Director RiverD International The Netherlands EPIC

Guido Perrone Professor Politecnico di Torino Italy EPIC

Guillaume Machinet Engineer ALPHANOV France EPIC

Helena Jelinkova Events Manager EPIC Czech Republic EPIC

Henk Leeuwis VP Strategy and Innovation LioniX International The Netherlands EPIC

Henk van der Poel Urologist NKI The Netherlands EPIC

Hikari Usami Project Manager Rakuten Medical Japan

Hiroyuki Kodama Director of Business Planning Rakuten Medical The Netherlands

Idelfonso Tafur Monroy Professor TU Eindhoven The Netherlands EPIC

Jacques Cochard Associate TEMATYS France EPIC

Johannes de Boer Professor LaserLaB Amsterdam, VU Amsterdam The Netherlands

Jonatan Klee Sales Manager Ushio Europe The Netherlands EPIC

Jonathan Marks Director Critical Distance The Netherlands

Jose Pozo CTO EPIC The Netherlands EPIC

Jouke Dijkstra Associate Professor Leiden University Medical Center The Netherlands

Participants


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Name Job Title Company Country Member

Julien Bec Engineering &Operations Director University of California USA

Kamal Kaur Project Coordinator UGent Belgium EPIC

Konrad von Volkmann Director of R&D Angewandte Physik und Elektronik Germany EPIC

Lukas Krainer CEO Prospective Instruments Austria EPIC

Maaike de Jong CTO Scinvivo The Netherlands

Marc Faucheux President Laser & Medical Devices Consulting France

Marloes Groot Professor LaserLaB Amsterdam, VU Amsterdam The Netherlands

Mauro Persechino Regional Sales Manager Optosigma France EPIC

Michiel Oderwald Senior Business Developer TNO The Netherlands EPIC

Mira Sibai Post doc CNRS France

Natalie Tuchapsky Company Director Superlum Ireland EPIC

Nicholas Stone Professor University of Exeter United Kingdom

Nicolas Lio Soon Shun Business Developer CEA-Leti France EPIC

Niels Verellen Principal Scientist imec Belgium EPIC

Oliver Pust Director Sales and Marketing Delta Optical Thin Film Denmark EPIC

Oliver Prochnow CEO VALO Innovations Germany EPIC

Paul De Keyser Sr Venture Development Manager imec Belgium EPIC

Paulina Mikolajczuk Marketing Manager SDS Optic Poland

Peter Vogt Director Field Sales Coherent Germany EPIC

Peter Tidemand-Lichtenberg Associate Professor DTU Fotonik Denmark

Pieter van der Zaag Principal Scientist Philips Research The Netherlands

Radhakrishnan Rajamanickam Project Specialist A_Photonics, AAlto University Finland

Ray Burke Senior Technical Manager Tyndall National Institute Ireland EPIC

Rubén Criado CEO Luz Wavelabs Spain EPIC

Ruud Verdaasdonk Health Technology Implementation University of Twente The Netherlands

Sabrina Matthias Product Manager asphericon Germany EPIC

Sami Musa CTO V&A-Photonics The Netherlands EPIC

Samir Lamrini R&D Manager LISA Laser Products Germany EPIC

Shawn Moran Global Market Manager LEONI Fiber Optics USA EPIC

Slava Artyushenko President art photonics Germany EPIC

Stefan Andersson-Engels Head of BioPhotonics Tyndall National Institute Ireland EPIC

Stefano Regusci Urologist SIPC Switzerland

Susan Brouwer de Koning Technical Physician NKI The Netherlands EPIC

Theo Ruers Oncological Surgeon NKI The Netherlands EPIC

Thierry Emeraud Business Development Manager Lambda-X Belgium EPIC

Torsten Wipiejewski Business Development Huawei Technologies Germany EPIC

Udo Fetzer Key Account Manager OFS USA EPIC

Willem Jan Mulder Director of Sales & Marketing Avantes The Netherlands EPIC

Zoe Ylöniemi Technical Sales Engineer Modulight Finland EPIC

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P H O T O N I C S P U B L I C P R I V A T E P A R T N E R S H I P

AEMtec is a global acting specialist for the development and production of customized and reliable micro- and optoelectronics. In the sector of miniaturization AEMtec provides a wide technology portfolio including Wafer Back-End Services, Chip on Board, Flip Chip, 3D Integration and Opto Packaging; all realized in cleanroom environment (ISO class 5 to 8). From concept to serial production including design and development, process management and industrialization the customers benefit from the services by a single source provider. AEMtec is certified by official organizations: ISO 9001, ISO 13485 (Medical) and ISO 14001 (Environment). www.aemtec.com

Dan Negrea (Senior VP for New Technologies) has an MScEE from the universities in Bucharest and Vienna, and MoT from IMD in Lausanne. Dan has led over the past 25 years multiple R&D teams in Austria, Switzerland and Germany. He joined AEMtec in 2008. Presently, he holds the position of VP for New Technologies with a clear focus on optical and space applications, thus enhancing the technology leader profile of AEMtec Berlin.

ALPhANOV is the Optics and Lasers technological center of the French Route des Lasers™ competitiveness cluster. Supported by the Aquitaine Region, it operates as a private, non-profit organization specialized in technology transfer in close collaboration with CEA/CESTA, CNRS, and the Bordeaux universities. ALPhANOV provides the technical resources and expertise required to fulfil the R&D challenge of innovative project in collaboration with SMEs and laboratories. Located in the Bordeaux area, ALPhANOV employs about 30 highly skilled Researchers, Engineers and Technicians. Its 700-m² facility hosts several dedicated technology platforms, specific laser and metrology systems available for projects in every field of optics and lasers. ALPhANOV conducts scientific research in photonic technology in collaboration with academic laboratories from the Bordeaux University. The Center’s expertise encompasses laser processing and micromachining, laser sources and optical fiber components, optical systems development and imaging. ALPHANOV is also currently involved in about ten laser technology-oriented national and European projects. www.alphanov.com

Guillaume Machinet (CTO Laser Sources & Components Business Unit) is working in ALPhANOV since 2017 as industrial manager of fiber laser development. Guillaume is also in charge of laser and health applications development. He has defended his PhD in 2012 at the University of Bordeaux (CELIA Laboratoy). The subject was to develop high power and high energy femtosecond ytterbium-doped fiber laser. Then he spent 4-years in Amplitude Systems in the R&D department to develop fiber and hybrid femtosecond lasers.

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Company descriptions and biographies


AUMC is first of the eight Dutch university medical centers. The AUMC hosts the Faculty of Medicine and the Faculty of Medical Informatics of the University of Amsterdam. The AUMC combines patient care, education, and research in numerous multi-disciplinary interconnections. This has resulted in many research lines combining the clinical practice and fundamental, high tech laboratories into translational research: the translation of high-tech solutions into clinical applications. In collaboration with the city of Amsterdam, the AUMC stimulates the development of a Medical Business Park with innovative industry and research institutes in the field of medical care, bio-sciences, and life-sciences. www.amsterdamumc.nl

Daniel Martijn de Bruin (Principle Investigator Urology) studied molecular biology at Hogeschool Utrecht and medical biochemistry at the University of Amsterdam. He received his PhD on clinical applications of Optical Coherence Tomography at the university of Amsterdam and Academic Medical Center. Currently, he is staff member at the department of urology and the biophotonics group at the department of biomedical engineering & physics both at the AMC. He holds several national and international grants, is principle investigator on multiple research projects and supervisor of 20 PhD students. He is member of the EAU, AUA, SPIE and COST and published over 90 papers covering optical and

digital diagnostic imaging technologies, artificial intelligence and novel focal interventional therapies to improve diagnosis, follow-up and treatment of benign and malignant disease.

Dick (H.J.C.M.) Sterenborg (Professor) received a M.Sc. in Applied Physics from the University of Eindhoven, The Netherlands in 1982 and he has been active in Biomedical Optics Research since then. From 1988 to 1998, he was a staff member of the Medical Laser Centre of the Academic medical Centre in Amsterdam. In 1998, he moved to the Erasmus Medical Center and (co)founded the Centre for Optical Diagnostics and Therapy and 2008 he was appointed Professor of Photodynamic Therapy at the Erasmus University. Since 2013, Dick fulfils a joint position at the department of Biomedical Engineering and Physics of the Academic Medical Centre in Amsterdam and the Surgical Innovations Group at the

Netherlands Cancer Institute. His main focus of research is currently optical spectroscopy and hyperspectral imaging for evaluation of resection margins.

APE is a worldwide trusted supplier of laser diagnostics and wavelength conversion for the ultrashort pulse (USP) laser industry. The diagnostics business covers autocorrelators for pulse width measurements, spectrometers, calibration light sources for cytometry, and other equipment for measuring and manipulating laser pulses. The business segment wavelength conversion includes optical parametric oscillators and amplifiers (OPO, OPA), frequency multiplication, as well as laser-sources for nonlinear Raman spectroscopy and label-free microscopy. APE is headquartered in Berlin, Germany, and was founded 1992. www.ape-berlin.de

Bodo Richter (CEO) finished his degree studies with a diploma in physical chemistry from the University of Bielefeld in 1997. After that, Bodo went to Berlin to continue his studies at the Fritz-Haber-Institute. He received a doctor´s degree from the Humboldt University with a thesis about surface science. This subject led him to a manufacturer of devices for surface analysis where he started his professional career in 2002. There, he worked in different functions, the last position being a production manager. Bodo took over the same position when he joined APE in 2010. Together with Cornelia Gläser, he was appointed chief executive officer in January 2015.

Edlef Büttner (Board Member and Senior Scientist) received his Master degree in Physics in 1981 from the Technical University of Dresden. He started his career in ultrafast laser physics in Berlin at the Institute of Scientific Instrumentation, where he worked on the generation and characterization of ultrashort laser pulses. In 1992 he co-founded the company APE GmbH, leading it as R&D manager. In 2015, he withdrew from operative business. Since then he has been focusing on strategic and special technical tasks for the future development of APE.

Konrad von Volkmann (Director of Research and Development) is responsible for managing the development department at APE. He studied physics at the FU in Berlin and in Bordeaux and finished his PhD in 2009 on ultrafast relaxation processes in condensed matter using ultrafast vibrational spectroscopy and time-resolved broadband THz spectroscopy. From 2010 onward, he worked at APE as product expert, project manager, team leader of the software development team and became Director of R&D in 2015.

A-Photonics is an Aalto University project engaged in pre-commercialization activities for its disruptive ultrafast laser technology which will enable new breakthrough applications in the medical, manufacturing and analytical instrumentation industries. A-Photonic's innovative picosecond active mode-locked fiber laser technology allows it to deliver high performance at a fraction of the cost and size of competing laser technology. www.aphotonicslasers.com

Radhakrishnan Rajamanickam (Project Specialist) is a Business Lead, exploring the global business opportunities in commercializing a research project A-Photonics (Aalto University, Finland). The key innovation centered around scalable silicon wafer based nanomodulator technology, for the entire near-infrared, SWIR and explored spectral regions. Lasers based on this technology open new horizons in medical imaging and surgery. Mr.Radhakrishnan M.Tech, M.S holds dual Masters degrees, one in Science and other management has over two decades of experience both in SMEs, Global corporations and university spin-offs. The expertise in centered out business planning, strategy management, operations

management, global procurement and sales. He is tech savvy and passion towards new technology and always look for the challenging opportunities.

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art photonics was founded in Adlershof in 1998 to develop and produce specialty fibers, fiber probes, laser cables and bundles for very broad spectral range from UV to Mid IR. While FlexiRay® fiber cables and bundles are focused on applications in laser technologies and medicine, the other product line FlexiSpec® provides the best fiber solutions for process-spectroscopy in biotechnologies, in chemical, petrochemical, pharma and food industries. FlexiSpec® fiber probes enable biomedical tissue diagnostics in-vivo and can be used for environment pollution monitoring in a field. www.artphotonics.de

Slava Artyushenko (President & CEO) was born in Russia. His PhD in physics was done at General Physics Institute, Moscow in 1981 - focused on his pioneering development of polycrystalline fibers for Mid IR-range: 3-18μm. His multiple publications and patents were devoted to fiber optic technologies and applications in laser medicine, process-spectroscopy, optical sensing and diagnostic. In 1998, he founded art photonics GmbH in Berlin – one of worldwide leaders now in the production of specialty fiber products for a broad spectra 0.2-16μm. Dr. V. Artyushenko and art photonics are members of EPIC, CPACT, IBioIC, SPIE, OSA, SAS, SPECTARIS, Optec-BB, Photonics-BB, GDCh-DECHEMA & CLIRSPEC.

asphericon has the passion for revolutionizing the manufacturing of optical elements with new technologies, which is changing the degree of precision and quality that is possible. By combining a worldwide unique CNC control technology with high-end manufacturing processes, we routinely achieve unique levels of dimensional precision for optical components, assemblies and systems. www.asphericon.com

Sabrina Matthias (Product Manager) received an Engineer's Degree focused in Optometry from Ernst Abbe Hochschule Jena / University of Applied Sciences Jena. For her diploma thesis, she studied the light guiding ability of the Müller cells in the vertebrate retina at the Paul Flechsig Institute, Leipzig. In 2009, she started her career at asphericon as a Sales Engineer. From 2014 until 2016, she became president of asphericon, Inc., the company’s North American subsidiary. After successfully establishing the Inc., she went back to her German roots and now proudly represents asphericon’s BeamTuning products.

Avantes is a world leader in the field of spectroscopy. They develop and manufacture spectrometers, light sources, software, fiber-optic cables and accessories. Avantes' products are highly customizable, adaptable to any specific application, and integrated into even the smallest housings. These products therefore find usage in many OEM applications and markets, as well as in the scientific and industrial world. With 25 years of experience, Avantes continues to produce innovative applications in diverse fields including chemical, solar energy, agriculture, gemology, (bio)medical, semiconductor, light measurement and food processing technology. www.avantes.com

Benno Oderkerk (CEO) has a background in electronics and medical technology. He studied at the University of Twente, Netherlands and did his master’s thesis at Technion, Israel Institute of Technology in Haifa in 1988. Since then, he worked for 5 years in a small sensor company in Munich and, in 1994, he started TOP Sensor Systems, which was renamed to Avantes in 2000. As a CEO, Benno is responsible for 100 employees worldwide as well as the strategic development of Avantes and its affiliated companies in China, USA and UK. Benno Oderkerk is President of the EPIC Board of Directors.

Willem Jan Mulder (Director of Sales and Marketing) studied electrical engineering at Windesheim, University of Applied Science and achieved his MSc. degree at Nyenrode Business University. He worked, 10+ years, in development and international sales and marketing in the field of fiber optic spectroscopy. In the actual role of Director of Sales and Marketing at Avantes BV, Mr. Mulder is responsible for leading and developing the sales and marketing team to meet their goals, together with the customer service and support team to achieve excellent customer experience. The Avantes instruments and accessories are deployed into many OEM applications as well as in many research institutes, industries and

markets throughout the world. With 25+ years of experience in fiber optic spectroscopy and thousands of instruments in the field, Avantes is eager to help our customers to find the perfect solutions for their spectroscopy challenges.

CEA-Leti is an applied-research institute located in Grenoble-France and specialized in micro and nano technologies. The ‘Optic and Photonic Department’ develops technologies in the field of lighting, display, sensing, imaging and communications. The department is integrated over the whole development cycle (Design, Fabrication and Tests), from the material (Si, Ge, III-V) to devices and circuit fabrication (200mm/8’’ CMOS fab, 100mm/4’’ III-V fab), packaging and test. In addition to Leti’s 1,700 employees, there are more than 250 students involved in research activities, which makes Leti a mainspring of innovation expertise. Leti’s portfolio of 1,880 families of patents helps strengthen the competitiveness of its industrial partners. www.leti.fr

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Nicolas Lio Soon Shun (Business Developer) worked as a key account sales engineer at STEMMER IMAGING, an imaging technology provider, after an engineering diploma at Ecole Nationale Supérieure d’Ingénieurs Electriciens de Grenoble (ENSIEG) in 2010. End of 2015, he joined the optics and photonics department (DOPT) of CEA-LETI in Grenoble as a business developer for thermal and terahertz imaging.

Chroma Technology is an employee-owned company that specializes in the design and manufacture of precision optical filters and coatings. The most advanced coating techniques have been developed that provide the greatest accuracy in color separation, optical quality and signal purity economically for OEM applications. We provide application engineering support, short cycle times and are as comfortable designing and manufacturing custom filters. The engineering team from Chroma’s instrumentation subsidiary 89North is focused on production of light sources and other opto-mechanical products for OEM and end-users. Founded in 1991 with main focus on optical filters for fluorescence microscopy, Chroma is today global player in the optical world, serving bio-medical research and analysis, machine vision and medical instrumentation. www.chroma.com

Georg Draude (General Manager) studied biology at Kassel University with a diploma in microbiology in the field of environmental cleaning. In 1999, he finished his PhD at Ludwig‐Maximilians‐University Munich in a medical research institute. Georg worked for several years as sales engineer for imaging‐solutions in medical and biological research and in the laser industry. He joined Chroma 2010 as key account manager Europe, became European sales director in July 2012 and General Manager of Chroma Europe in September 2015.

Almut Bailly (Account Manager) studied biology at Kassel University with a diploma in limnology and botany. She specialized in soil protection and worked in the field of environmental protection and cleaning with a big engineering company. She was head of the office in Hirschhagen and Kassel from 2007-2011. Almut joined Chroma Technology as sales representative in May 2011 and became account manager in 2012.

CNRS, The National Center for Scientific Research, is a public organization under the responsibility of the French Ministry of Education and Research. Founded in 1939 by governmental decree, the CNRS aims to: evaluate and carry out all research capable of advancing knowledge and brining social, cultural and economic benefits for society; contribute to the promotion and application of research results; develop scientific information; support research training; participate in the analysis of the national and international scientific climate and its potential for evolution in order to develop a national policy. www.cnrs.fr

Mira Sibai (Physicst) in training with 8 years of translational research. currently a postdoctoral fellow at CNRS responsible for validating a bimodal fibred optic probe developed in house by Dr. Darine Abi Haidar to detect and differentiate different brain tissue types, mainly tumor, epileptic and normal cortical tissue. I correlate optically derived metrics to pathological processes so that in situ tissue diagnosis is obtained intraoperatively noninvasively and in real time. I have completed my PhD in medical biophysics at the university of Toronto under the supervision of Dr. Brain Wilson. Through my PhD I developed a quantitative fluroescence imaging modality to detect brain tumors at the surface and below

the surface during surgery. I am looking for the next adventure aimed at bringing advanced research based technologies to the healthcare sector.

Darine Abi Haidar (Physicist and Associate Professor) is a Physicist and an Associate Professor at IMNC laboratory, section 30 at university Paris Diderot-Paris7. She is the director of the nonlinear optical imaging platform of small animals at IMNC Lab. For the last 10 years, her research activities have focused on nonlinear optical imaging microscopy, optical tissue characterization, development of fiber probe-based spectral systems and on non-linear endomicroscopes. Through this rich experience, she has acquired a strong knowledge in the field of pulse pre-compensation, distal optics TPF and SHG signal optimization, and optical characterization of brain tumors on animal models using

spectral and lifetime domain measurements, while obtaining a progressive background in the field of oncology.

Coherent, founded in 1966, is one of the world’s leading providers of lasers and laser-based technology for scientific, commercial and industrial customers. With headquarters in the heart of Silicon Valley, California, and offices spanning the globe, Coherent offers a unique and distinct product portfolio and services for Scientific Research, Life Sciences, Microelectronics & Semiconductor processes, and Materials Processing. In November 2016 Coherent and ROFIN merged to form the world’s largest photonics company. Coherent differentiates from other laser manufacturers by offering the broadest product portfolio available. This unsurpassed portfolio of lasers varies in wavelength, average and peak power to be subtle enough for DNA studies, precise enough for microelectronics, and powerful enough to cut the strongest steel. From continuous-wave to

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femtosecond lasers, from a few milli-Watts up to multi kilo-Watts of power combined with in-depth process development skills, we are the ideal partner for deployment of photonics in Science and Industry. Coherent develops and produces a large proportion of its products in Europe, including diode and fiber laser components, high repetition rate short pulse lasers, diode-pumped solid-state lasers, optically pumped semiconductor lasers, ultrafast lasers, excimer lasers up to industrial fiber, diode and CO2 lasers as well as laser-based system solutions. We employ approximately 2,800 people in Europe. www.coherent.com

Peter Vogt (European Director of Sales) started his career at Coherent in 1995 as scientific field sale engineer in Germany. He holds a PhD in Physical Chemistry (Raman & Laser Spectroscopy) of University Wuerzburg and a mini MBA of Management Center Europe (Brussels). He worked in different Sales Positions as Market Development Manager, Key Account Manager, Country Sales Manager and has vast experience the following laser markets: Scientific & Research, Instrumentation & Medical, Material Processing and Semiconductor Capital Equipment. Since 2015, he is European Director of Sales leading the Field Sales Force of Coherent in Europe mainly covering scientific customers. He is a member

of the European Sales Staff. 2019 he was together with Prof. Juergen Popp (Jena) chair of the ESULaB conference (www.esulab.org) in Jena.

Critical Distance is working closely with several Photonics-related organisations, including EPIC, to explain the current relevance of Photonic Applications to the rest of the world. The work in 2020 will involve assembling more profiles of the most innovative companies into several investment portfolios. We're currently focused on Medical, Agri-tech and THz sensors as well as certain photonics pilot-lines. Jonathan Marks leads a guild of independent writers, reporters, producers and researchers to make this happen. We also design and launch communications strategies for companies who want to introduce disruptive products, but need practical help in telling powerful stories. Some work is done under NDA. Contact [email protected] and mention EPIC in your email. www.jonathanmarks.com

Jonathan Marks (Director) is a British science analyst and strategic thinker based in the Netherlands. He is an active documentary maker and international broadcaster specializing in media analysis and scientific reporting. Jonathan contributes regularly to mainstream media as well as hosting the Media Network podcast. He is particularly passionate about the success of Photonics and all the fascinating applications it drives.

Delta Optical Thin Film is a world-leading manufacturer of optical thin film filters with more than fifty years of experience. Through continuous development of new design and production technology Delta Optical Thin Film helps the world’s leading manufacturers of diagnostic and analytical instruments in setting new standards. With its unique and advanced optimisation software to match customers’ particular optical specifications, Delta Optical Thin Film ensures a fast and efficient design process. Delta Optical Thin Film fluorescence filters and Continuously Variable Filters are used in challenging applications such as fluorescence microscopy, spectroscopy, flow cytometry, wavelength selectors, high-performance monochromators, biomedical laser systems, Point of Care (PoC) instruments, image transferring systems, hyperspectral imaging and optical coherence tomography. www.deltaopticalthinfilm.com

Oliver Pust (Director, Sales and Marketing) has a background as mechanical engineer and earned his doctoral degree within the field of laser optical measurement techniques. He has a long-term experience in working together with international partners and sales of high-tech equipment to research and industry customers and joined Delta Optical Thin Film A/S in 2011.

At DTU Photonics Engineering at the Technical University of Denmark, we research into understanding the nature of light and all the ways in which we can control and use light. Photonics Engineering has become a key enabling technology for our society and is used, for example, for our communication infrastructure, in the healthcare sector for the treatment of diseases and for secure communication on the Internet. www.fotonik.dtu.dk

NLIR is spin-off from the Department of Photonics Engineering, it is based on the novel patented upconversion technology invented by its founders at DTU Fotonik. The core of the upconversion technology is non-linear frequency conversion of mid-infrared to near visible light. This enables the use of fast and efficient Silicon based sensors for detection of MIR light. Our non-linear mid-infrared sensors represent a revolutionary new measurement paradigm. NLIR focus on mid-infrared spectrometer products technological different from today’s leading MIR spectrometry method based on Fourier-Transform InfraRed spectroscopy (FTIR). www.nlir.com

Peter Tidemand-Lichtenberg (Associate Professor, DTU Fotonik and Co-founder of NLIR) completed his PhD from the Department of Physics, Technical University of Denmark in 1996. After 5 years in a private startup company, he returned to the University. His main research activities relate to ultra-sensitive infrared detection systems, with a strong focus on real life applications, generally within spectroscopy for gas sensing or medical diagnostics.

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EKSPLA Innovative manufacturer of solid state and fiber lasers, systems and components from custom system to small OEM series. In-house R&D team and more than 25 years’ experience ensure operative design, manufacturing and customization of the new products. For OEM customers who need reliable laser equipment delivered on time, Ekspla provide specifically optimized and tailored solutions that enable to make customers’ product unique. Unlike of the shelf manufacturers, EKSPLA provide close partnership, collaboration and our commitment that will help to create value to your customers. www.ekspla.com

Mantvydas Jasinskas (Chief Sales Officer) managed laser product line, dedicated for photo acoustic imaging application, which has potential to be used in breast cancer and other disease diagnosis. His work is driven by curiosity and passion for photonics and medical advancements. Mantvydas graduated Engineering in Vilnius University in 2011. Afterwards, he worked as laser engineer in eye surgery clinic, as technical customer support engineer and later, as product manager in EKSPLA. He has a diverse eight-plus years experience in building relationships with customers and managing laser products in industrial, R&D and biomedical laser markets. Since June 2018 Mantvydas is leading EKSPLA sales team.

EPIC is the European industry association that promotes the sustainable development of organisations working in the field of photonics. Our members encompass the entire value chain from LED lighting, PV solar energy, Silicon photonics, Optical components, Lasers, Sensors, Displays, Projectors, Optic fiber, and other photonic related technologies. We foster a vibrant photonics ecosystem by maintaining a strong network and acting as a catalyst and facilitator for technological and commercial advancement. EPIC works closely with related industries, universities, and public authorities to build a more competitive photonics industrial sector, capable of both economic and technological growth in a highly competitive world-wide marketplace.www.epic-assoc.com

Jose Pozo (Director of Technology) is a Senior Photonics specialist with extensive background in technology, market knowledge and an eye for business opportunities, with 14+ years of professional background. Experienced at building consortia and supply chains for the development of innovative solutions towards improving the state of the art of the Photonics Industry. Highly regarded scientist as well as an award-winning conference speaker with over 70 publications (including a Nature paper in 2015). Member of the board of IEEE Photonics Society – Benelux.

Elena Beletkaia (Project Leader) graduated from Lomonosov Moscow State University (MSU) specializing in biophysics. In 2015 she acquired her PhD in Leiden University with her research focusing on biochemical and biophysical mechanisms underlying metastasis of Ewing sarcoma. Later in collaborative setting of NKI and Twente University, Elena investigated application of a non-invasive spectroscopic/multiphoton methods for intraoperative resection margins assessment. All her research projects involved understanding and use of multiple micro- and spectroscopic techniques.

Helena Jelínková (Events Manager) studied Business Administration and Management at Thomas Bata University in Zlin, Czech Republic. Her passion for travelling brought her into the hospitality and tourism industry. She worked for several international hotel brands in Prague at various positions both in the operations and sales department. She dedicated most of her professional life to events. Projects she worked on range from corporate conferences and meetings to sport tournaments or weddings. In June 2019, she has joined the EPIC team as their second Events Manager.

ETH Zurich is a one of top leading university in Europe and in the world since its foundation in 1855 in Zürich, Switzerland. Over the decades, multiple connections have been developed and fostered with universities and companies all over the world, leading to more than 400 approved projects within the Seventh Framework Programme for Research and Innovation (FP7). The Department of Physics (D-PHYS, www.phys.ethz.ch) and the Department of Information Technology and Electrical Engineering (D-ITET, www.ee.ethz.ch) have in particular a long experience working in the field of photonics. With several national centers of competence in research (NCCR), state-of-the-art facilities and laboratories (FIRST, FastLab, etc.), ETH Zurich is pushing the frontiers in the fields of quantum optics, quantum cascade laser, ultrafast lasers, THz, optical communications, nanophotonics and several other areas. www.ethz.ch

Chris Phillips (Senior Research Scientist) works at ETH Zurich on ultrafast laser physics topics. He obtained his PhD at Stanford University working on ultrafast nonlinear optics. Afterwards, he moved to ETH Zurich as a Marie Curie International Incoming Fellow, developing microstructured nonlinear-optical devices for femtosecond pulse amplification. After this postdoctoral fellowship he stayed at ETH and moved into a senior research scientist role supervising a variety of research projects combining ultrafast lasers and nonlinear optics techniques. His current efforts include high repetition rate mode-locked oscillators and frequency combs; ultrafast mid-infrared light generation in micro structured

nonlinear devices; high power lasers in the mid-infrared, near-infrared, and deep-ultraviolet; and generation of extreme ultraviolet light for attosecond spectroscopy.

Femto diagnostics was started in 2016 by Frank van Mourik, for consultancy about the application of non-linear optics in biomedical microscopy and spectroscopy. For the research group of Marloes Groot at the VU Amsterdam we developed a microscope on wheels that enables “pathology” on excised tissue without the need for fixation and/or staining. By using the contrast mechanisms of second and third harmonics generation in tissue, and multi photon (auto)fluorescence, “pathology quality” images can be obtained within minutes after excision. The technique works at low average powers (< 5 mW), thus avoiding damage to tissue, and could be adapted for in vivo applications.

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Frank van Mourik (CTO) has studied the femtosecond dynamics of photosynthesis in Amsterdam (VU), Chicago, and Mülheim (Max Planck institute fur Strahlenchemie). From 2000 to 2016, he worked on the development and application of ultrafast spectroscopic techniques and instrumentation for the study of biomolecules, at the EPFL in Lausanne, Switzerland. Upon his return to the Netherlands in 2016, he started Femto diagnostics to exploit his vast knowledge and experience in the instrumentation and techniques of non-linear optics.

Huawei, founded in 1987, is a leading global provider of information and communications technology (ICT) infrastructure and smart devices. We have nearly 188,000 employees, and we operate in more than 170 countries and regions, serving more than three billion people around the world. Huawei's end-to-end portfolio of products, solutions and services are both competitive and secure. At Huawei, innovation focuses on customer needs. We invest heavily in basic research, concentrating on technological breakthroughs that drive the world forward. www.huawei.com

Torsten Wipiejewski (Business Development Manager) joined Huawei Technologies in 2014 and is responsible for the European business development of Huawei’s Hardware Engineering Institute. He has also been appointed as Technical Advisor to president of Huawei’s European Research Institute in 2017. Torsten’s interest covers a wide range of technologies and materials for all the company’s products from consumer electronics, smart phones and watches to routers and optical communication. Previously, Torsten was a partner at the venture capital firm VNT Management Oy and the CEO of Optogan a company based in Finland and Germany making blue LED chips. Prior to that he was the

Chief Operations Officer at Firecomms Ltd. in Cork, Ireland where he was responsible for Firecomms’ worldwide production and product development of low cost leadframe based fiber optic transceivers and visible vertical-cavity laser (VCSEL) products. Torsten was also Vice President of the Photonic Components group at ASTRI in Hong Kong and Director and Program Manager at Agility Communications in Santa Barbara, CA, USA and he held management positions at Infineon, Osram, and Siemens in Germany. Torsten received a “summa cum laude” Ph.D. degree in electrical engineering from the University of Ulm in 1994.

Imec leverages its expertise in chip design and technology to develop innovative tools for the life sciences, pharma R&D, clinical diagnostics, therapeutic and surgery, biopharma production and analytical biochemistry industries. We combine extensive chip manufacturing facilities and bio-lab infrastructure with world-renowned expertise in chip technology, MEMS, bio-electronics, sensors, photonics, imagers, microfluidics, and biosciences. We work with strong, multidisciplinary teams of world-class scientists. This makes us the ideal development and manufacturing partner for your custom smart biochip solutions, from early R&D, design and prototyping to volume manufacturing. www.imec-int.com/en/lifesciences

Paul De Keyser (Sr Venture Development Manager) graduated as MSEE in Micro-Electronics from the University of Leuven and holds an MBA from Flanders Business School. His passion has always been to bring new technology-based products to market, such as the first digital cameras. At Agfa Healthcare, he pioneered OCT and Terahertz imaging. He started and managed Agfa’s Direct Radiography business worldwide. At the Belgian Nuclear Research Center, he was instrumental in the creation of a Medical Campus to research and produce cancer-targeted radio-immunotherapy drugs. At IMEC, Paul is developing new ventures in several fields – all of them spin-offs based on IMECs ground-breaking technologies.

Niels Verellen (Principal Scientist) develops integrated photonics technologies at imec’s Life Science Technologies department. He received his MSc (2007) and PhD (2011) degrees in Physics from KU Leuven. His PhD research in the field of plasmonic nanomaterials was awarded the Umicore Scientific Award 2012. From 2011-2016, he was FWO postdoc at KU Leuven and imec, investigating optical nanoantennas and near-field imaging beyond the diffraction limit. In 2014, he worked on optical quantum sensing at the California Institute of Technology (Caltech, US). He (co-)authored more than 50 peer-reviewed publications. Recently, he received an ERC Starting Grant for the development of a high-

resolution on-chip and lens-free fluorescence microscopy platform.

Since its beginnings in 1945, the KARL STORZ family company has grown into a global manufacturer and distributor of endoscopes, medical instruments, and devices. Our range of endoscopic instruments for human medicine, veterinary medicine, and industrial endoscopy now includes more than 15,000 products. The most recent KARL STORZ developments are in digital documentation systems and comprehensive operating room concepts. As a system supplier, the company combines its expertise in endoscopy with software solutions to achieve integration in the operating room and to support clinical process and resource management. www.karlstorz.com

Antje Haap-Hoff (Head of Clinical Applications) is the head of clinical applications at the endoscopic medical device company KARL STORZ SE & Co. KG, Tuttlingen, Germany. She joined the company in 2013 as marketing manager for fluorescence imaging systems after her science career in cell biology where she focused on cellular (high throughput) fluorescence microscopy. Her previous position as an assistant professor at Trinity College Dublin encompassed siRNA screens with a T cell migration model founded by the Marie Curie program (FP7).

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LUMC (Leiden University Medical Center) is an academic hospital in the Netherlands. It aims at identifying the causes of disease, improving diagnosis, prevention, and ultimately developing effective treatments. Current science crosses traditional borders. Within LUMC different specialists work together around research themes. Combining cross-border expertise may solve biomedical problems and bring answers not found when working in a standalone fashion. The medical research profile is carefully chosen in order to combine clinical and fundamental areas of expertise. One of the focus areas is the introduction of new image guided techniques into the surgical room, including the enhancement of the digital pathology. www.lumc.nl

Jouke Dijkstra (Associate Professor) holds a post as Associate Professor at Leiden University Medical Center (LUMC), where he is the leader of the “vascular and molecular imaging” section. The LUMC is an academic hospital in the Netherlands and one of the focus areas is the introduction of new image guided techniques into the surgical room, including the enhancement of the digital pathology. Dr. Dijkstra is responsible for the molecular imaging post-processing research including image guided surgery. He is co-Principle Investigator of the CTMM – MUSIS project. MUSIS is a government sponsored projects about the development of methods for image guided surgery, both open en endoscopic surgery using

multispectral imaging and fluorescent cancer targeting probes for better tumour resection. It also includes a European grant project (Carioca) about the use of Optical Coherence Tomography for better tumour resection by inspecting the tissue with an in-vivo OCT microscopic device. He is responsible for the research in vessel imaging, in particular IntraVascular UltraSound, Optical Coherence Tomography and Computed Tomographic Angiography. The research resulted in several scientific publications and analytical software packages, which have been transferred to the industry and are used worldwide. An important aspect in his section is to bring new technologies into the clinical arena.

To a wide selection of industries (ophthalmic, equipment manufacturing, industrial processes, space, medical, glass manufacturing, automotive, imaging and lighting systems), Lambda-X provides innovative and differentiating optical-based solutions in multiple and often complex industrial environments. To help customers develop new products and improve metrology, process and quality control operations. In the medical sector Lambda-X is proposing technologies and products for medical devices, IVD, chemometrics, tissue engineering and cell therapy. www.lambda-x.com

Thierry Emeraud (Business Development Manager for Industry) joined Lambda-X (& Verhaert Group) in 2015. Thierry has a solid-state physics background & obtained a Ph.D. in Photovoltaics. He has built a 25+ years’ experience in the industry with different positions in technical, marketing & sales and management. Among others, he has gathered a vast experience in metrology systems and process equipment for multiple industries in Europe, Japan, Asia and USA. At Lambda-X Thierry helps customers boost their innovation and feed their growth with custom optical systems for metrology and imaging applications.

Didier Beghuin (CTO) is leading a team of 20 engineers dedicated to the development of optical instrumentations since 2013. He is involved in optical developments since 2000. He developed metrology instrumentation for ophthalmic industry, sighting systems for defense, and series of custom microscope for biomedical sector. Being involved in space activities, he also led optical imaging or metrology developments for earth observation or microgravity science.

LaserLaB Amsterdam is part of a European consortium of laser centers focused on the research in optics and photonics. The mission of LaserLaB Amsterdam is ground breaking scientific research based on the interaction of light with matter, spanning from the research on atoms and molecules to the investigation of living cells and tissue and sustainable energy sources. Our division in particular is closely collaborating with physicians at other institutes such as Amsterdam University Medical Centers and Utrecht Medical Center in order to design and develop cutting edge diagnostic tools for medicine. www.laserlab.vu.nl

Marloes Groot (Professor) is full professor in Biophysics in the section of Biophotonics and Medical Imaging at the Department of Physics, Faculty of Science/LaserLaB of the Vrije Universiteit in Amsterdam. Current research is focused on ultrafast dynamics in proteins and on deep tissue imaging with higher harmonic generation microscopy. Her interest with the latter technique spans from diagnostics for clinical application to the study of cellular processes in live tissue. She has several running projects with clinicians to translate the results of her research to the clinic. She collaborates with Femto Diagnostics BV to commercialize higher harmonic generation microscopes for instant pathology.

She is program director of the bachelor Medische Natuurwetenschappen and the master Biomedical Technology and Physics.

Johannes de Boer (Professor and Chair Biophotonics, Dept. of Physics) studied Physics at the University of Amsterdam before becoming a post-doc and faculty at the Beckman Laser Institute, UC Irvine, and the Wellman Center for Photomedicine, MGH, Harvard Medical School. In 2008, he became a full professor in the department of Physics, VU Amsterdam. Dr. de Boer is a pioneer of Optical Coherence Tomography, making seminal contributions to Polarization Sensitive OCT, Spectral Domain/Fourier Domain OCT, Doppler and attenuation imaging. More recently, he focuses on the combination of near infra red fluorescence detection of fluorescently labeled monoclonal antibodies combined with structural OCT imaging to develop the optical equivalent of PET/MRI or PET/CT.

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Laser & Medical Devices Consulting (LMDC) can accompany you and will provide assistance, consultancy and expertise and help you to succeed with your innovative projects. Our services: Business development, Technical expertise, Market study and road map. Our topics are: Photonic technologies and their applications, Medical Devices, Instrumentation, Quality Management and Regulatory affairs. Our method: Close relationship with clients, High reactivity and flexibilty of a small structure, product oriented. www.l-mdc.fr

Marc Faucheux (President) has a Plasmas Physics PhD from Pierre et Marie Curie University of Paris and has worked for more than 30 years, first in Aeronautic and Spatial photonics and then as responsible of Medical Laser development at Quantel. He has acquired a large experience in strategy and photonic devices development and also for quality assurance management. Based on his experience, Marc Faucheux has created a consulting firm: Lasers & Medical Devices Consul琀ng (LMDC) in 2010. Since 2010, companies (start-ups, SME and large groups), research laboratories (public or private) and public organizations have believed in LMDC.

LEONI is a global provider of products, solutions and services for energy and data management in the automotive sector and other industries. The value chain encompasses wires, optical fibers, standardised cables, special cables and assembled systems as well as intelligent products and smart services. As an innovation partner and solutions provider, LEONI supports its customers with pronounced development and systems expertise. The group of companies, which is listed on the German MDAX, employs more than 86,000 people in 31 countries and generated consolidated sales of EUR 4.9 billion in 2017. www.leoni-fiber-optics.com

Angelina Bogatzki (Manager Product Engineering Medical Devices) studied Photonic at TH Wildau with a Master of Engineering degree. Since 2016, she joined the LEONI Fiber Optics GmbH. As Manager Product Engineering Medical, Angelina is responsible for development and lifetime cycle, including corresponding technical documentation for our medical Devices. The LEONI Fiber Optics GmbH produces since more than ten years medical laser probes for various applications and is represented worldwide.

Shawn Moran (Director of Sales & Business Development & Global Market Manager) is the Director of Sales & Business Development and Global Market Manager for LEONI’s medical device portfolio. With more than 15 years’ experience in medical device sales and fiber optic based medical devices, Mr. Moran is responsible for the overall strategy of LEONI’s global medical device business, as well as business development activities.

LioniX International is a leading global provider of customized microsystem solutions,in particular integrated photonics-based, in scalable production volumes. We provide customized solutions for OEM’s and System Integrators, from design to device, by vertical integration in scalable production volumes and maintaining technology leadership secured by strong IP position. As LioniX International we focus on Photonic Integrated Circuits (PIC) enabled modules based on our proprietary waveguide technology (TriPleX™), in addition to our other core competences micro-fluidics, opto-fluidics and MEMS. As vertically integrated company we deliver a complete solution to our OEM customers: from initial design through volume manufacturing of products. www.lionix-international.com

Henk Leeuwis (Vice-President, Strategy and Innovation) obtained his MSc degree in Electrical Engineering at the University of Twente. He has been active in micro/nano system technology for over 35 years. In January 2002, he became Executive VP at LioniX BV (since 2016 LioniX International BV) and, since 2012, he is Vice-President Strategy and Innovation. He has been and is active in numerous European programs as project leader for RTD projects and as proposal evaluator. He is Honorary Founder of the Dutch Micro/Nano Technology Association MinacNed and is involved in numerous governmental task forces and committees. Henk Leeuwis is active in business development for lab-on-chip technology over

the last 25 years including collaborations with biotech, pharma and medical partners. He is one of the initiators in establishing an ecosystem in the area of Personalized Medicine and Companion Diagnostics in the Netherlands.

LISA Laser Products has been founded 1989 in Katlenburg-Lindau, Germany. Since then the company is the trendsetter in surgical laser systems. The core competence of LISA Laser Products is in the development, manufacturing, sales and marketing of medical lasers at 2 μm wavelength based on Holmium and Thulium lasers. LISA Laser Products owns the longest experience in Holmium lasers in the industry dating back to the scientific work of its founders who did grow and lase the Holmium YAG crystal first worldwide. LISA Laser Products also developed and introduced the Thulium YAG laser for soft tissue surgery. The stimulus for continuous product research and development at LISA Laser Products is the optimization of minimally invasive and endoscopic surgical laser procedures - to the benefit of patients and customers. Many of these products have been developed in close collaborations in the frame of research projects which have been funded by the European Commission and the German Federal Ministry of Education and Research. www.lisalaser.de

Samir Lamrini (R&D Manager) studied electrical engineering and holds a Ph.D. in laser physics since 2012. His research activities cover mid-IR lasers for industrial and medical applications. In the past, he published several papers and conference contributions demonstrating high performance fiber and crystal lasers. Since 2019, he is R&D Manager at LISA and drives the development of novel medical lasers for minimally invasive procedures and high patient safety.

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Luz Wavelabs is a Spanish spin-off focused in the development of reliable and high-quality Instrumentation & Test systems for Photonics and mm-wave regions. The core products of the company are high performance, laser and PIC controllers, and pure/mm, a signal generator up to 110 GHz with a modulation bandwidth of 40 GHz. www.luzwavelabs.com

Rubén Criado (CEO) is the co-founder and CEO of Luz Wavelabs from 2013. He received his BSc, 2 MSc and PhD on Engineering by Universidad Carlos III de Madrid (UC3M) and BSc on Business Science by UNED. He has been awarded with several prizes, such as “Innovator under 35 2015”, awarded by MIT Technology Review; "Innovator of the Year", awarded by SEAT or "Most disruptive minds of the year", awarded by QUO Magazine.

Modulight is an ISO9001, ISO14001 and ISO13485 certified company focusing on design, development and manufacturing of laser diodes and laser systems. Modulight lasers are deployed mainly in medical, industrial, security/defence and display/projection markets. The company provides components and turnkey laser systems with wavelengths range between 405 nm and 1650 nm and power levels up to 100 W along with design and implementation of sub-system level laser integration including cooling, drivers and mechanical design. The products are offered from bare and mounted laser chips to packaged and fibre-coupled lasers and complete turnkey laser systems. The Company has in-house laser diode production facilities and headquarters in Tampere, Finland and a fully owned subsidiary Modulight USA, Inc., based in San Jose CA. www.modulight.com

Zoe Ylöniemi (Technical Sales Engineer) studied biomedical technology at the Tampere University (Finland) and did her thesis work at esteemed cancer center Roswell Park Cancer Institute (Buffalo, New York). At Modulight, she has been involved in numerous medical laser development projects and nowadays her focus is on medical device sales and account management.

Monocrom designs and manufactures low and high-power diode laser devices, mainly for medicine, aesthetics, material processing, pumping, science, defense, aero-spatial, instrumentation and graphic arts industry. Monocrom has been recognized throughout the laser industry for supplying high performance products at a competitive price due to its unique and patented "clamping" technology. Monocrom's products are alike appreciated for their custom-fit characteristics, high reliability and long lifetime. Our experience in the laser field has demonstrated the applicability of new concepts in laser physics, like our Q-Switched green solid state laser, capable of providing microseconds pulses and considered one of the most important developments in eye surgery from the last years, or our ultra-light weight and resistant green laser device designed for a Space mission to MARS (ExoMars). www.monocrom.com

Elad Volfin (VP Sales & Business Development) began his technological journey in RF and Electro Magnetics more than 20 years back with a PE in Electronics and computer. Along the way, he shifted to Program management until he finally landed in the commercial department. Since 2015, he is the VP Sales and Business Development at monocrom, a young in spirit growing laser company from the lovely a rea of Barcelona.

The Netherlands Cancer Institute (NKI) for decades has been among the absolute world top when it comes to the unique connection between the care and research that makes all the difference for cancer patients. In multidisciplinary teams, surgeons, oncologists, radiologists, radiotherapists and nurses are continuously working on tailor-made treatments. Because in essence no two cancers are the same. As it is now becoming possible to unravel the specific genetic changes in the nucleus of the cancer cell that influence the behavior of the tumor, our researchers are increasingly capable of developing new, tailor-made treatments. The Netherlands Cancer Institute chose, already a century ago, for the ground-breaking approach of combining the research at the Netherlands Cancer Institute with the specialized cancer care of the Antoni van Leeuwenhoek hospital. The institute is located in Amsterdam. It is the only OECI designated Comprehensive Cancer Center in the Netherlands, and is an important national and international center of scientific and clinical expertise, development and training. www.nki.nl and www.avl.nl

Theo Ruers (Head of the Division Surgical Oncology) is the head of the Division Surgical Oncology at the Netherlands Cancer Institute Amsterdam. As a surgeon, his main field of interest is colorectal cancer and liver surgery, with special interest for image guided surgical procedures. He is clinical professor at the Technical University of Twente on the application of biomedical imaging and treatment strategies in oncology. Theo Ruers was trained as surgical oncologist in The Netherlands and the UK. He is leading the research division of surgical oncology of The Netherlands Cancer Institute which is focussing on imaging techniques for on diagnosis and treatment of cancer. He is a member of several international surgical oncology societies and research societies.

Henk van der Poel (Head of the Department of Urology) is head of the department of Urology at the Netherlands Cancer Institute in Amsterdam with focus on prostate cancer management. He is editor-in-chief of the Netherlands Journal of Urology and has (co)authored more than 250 peer-reviewed publications in the field of urology and has conducted several prospective clinical trials on improvements of surgical techniques in prostate cancer management. He was board member of the Dutch Association of Urology for 12 years and since 2014 he is member of the EAU guidelines committee on Prostate Cancer. He is actively participating as a mentor in the surgical and theoretical training in urology on national and international level as a board member of the European School of Urology.

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Susan Brouwer de Koning (Ph.D. Student) graduated from her studies in Technical Medicine (University of Twente) in March 2016 with a special interest in medical imaging and interventions. Due to her interest in intra-operative imaging technologies, she is working at the NKI as a PhD student and as a member of the Clinical Implementation Team, responsible for the implementation of new technologies in the operation room. At the moment, she is researching the potential for diffuse reflectance spectroscopy and hyperspectral imaging to assess tumor margins intra-operatively.

Dick Sterenborg (H.J.C.M.) (Professor) received a M.Sc. in Applied Physics from the University of Eindhoven, The Netherlands in 1982 and he has been active in Biomedical Optics Research since then. From 1988 to 1998, he was a staff member of the Medical Laser Centre of the Academic medical Centre in Amsterdam. In 1998, he moved to the Erasmus Medical Center and (co)founded the Centre for Optical Diagnostics and Therapy and 2008 he was appointed Professor of Photodynamic Therapy at the Erasmus University. Since 2013, Dick fulfils a joint position at the department of Biomedical Engineering and Physics of the Academic Medical Centre in Amsterdam and the Surgical Innovations Group at the

Netherlands Cancer Institute. His main focus of research is currently optical spectroscopy and hyperspectral imaging for evaluation of resection margins.

NB-Photonics was established in 2010 as one of five Multidisciplinary Research Platforms (MRPs) in a Ghent University research policy plan for promoting excellence in research. These MRPs were selected by recognition of established expertise, multidisciplinary collaboration and potential to become world leaders. The NB-Photonics concept emerged due to several realizations. Our society is faced with important challenges, such as, qualitative and affordable healthcare, clean and renewable energy, and efficient ICT. Key Enabling Technologies (KETs) within photonics, nanotechnology, and biotechnology have the potential to help provide solutions. The intricate nature of the challenges at hand necessitates a multidisciplinary approach. NB-Photonics solves such challenges and provides training through our members’ expertise and their facilities in combination with academic and industry collaborating partners. www.nb-photonics.ugent.be

Kamal Kaur (Project Coordinator) holds two masters degrees in - Physics (2002) and Applied Optics (2004)- from Indian Institute of Technology Delhi, India. She then joined Optoelectronics Research Centre, University of Southampton, UK in Oct 2007 as research student and obtained her PhD in 2011 in the area of Ultrafast lasers for printing materials and photonic devices. She held a post doc position at LP3, CNRS lab from 2012- 2014. After that, she held a post doc position at CMST, UGent from 2012- 2015. She worked as a senior scientist at the Belgian company Skylane Optics from 2015- 2017. Currently, she is coordinating the multidisciplinary expertise centre “Center for Nano- and Biophotonics (NB Photonics)” at UGent.

NKT Photonics is the leading supplier of high performance fiber lasers, fiber optic sensing systems, and photonic crystal fibers. Our main markets are within imaging, sensing and material processing. Our products include ultrafast lasers, supercontinuum white light lasers, low noise fiber lasers, distributed temperature sensing systems and a wide range of specialty fibers. We have lasers in space and deep under the oceans and our products run in both clean rooms and on oil rigs at sea. We seed the world’s largest laser fusion experiment and power hundreds of the most advanced microscopes on the globe. We aim to make a difference in the world and we are involved in projects that will transform the way we live through life-science, renewable energy and the basic understanding of the universe. With over fifteen years of expertise, IP and experience, NKT Photonics strives to continually be the market leader in everything we do. NKT Photonics has its headquarters in Denmark with sales and service worldwide. NKT Photonics is wholly owned by NKT A/S. www.nktphotonics.com

Deepak Nair (Product line Specialist) finished his master’s degree in Photonics from Cochin University of Science and technology, India in 2007 and a received a PhD in Diode laser technology from the Technical University of Denmark in 2010. Since 2011, he has been involved in optics R&D roles with different high-tech companies in Denmark. In 2017, he started his role at NKT Photonics as a product development engineer and where now he works as a Product Line Specialist with the responsibility of strategic marketing of the SuperK line of lasers and accessories where he interfaces with the operations, sales and R&D departments.

OAL Innovations was established in 2003 as a company that focuses on photonics solutions and innovation. Our experience over the years with state-of-the-art technology and interdisciplinary innovative system design, has yielded into a set of companies and industrial science in the field of electro-optics, solar trackers, lasers, IR etc... Today, the company implants optics technologies in medical devices and solar science, for example: over the counter skin cancer detector, skin rejuvenation and hair removal. www.oalinnovations.com

Galit Ankri-Eliahoo (Medical Device Project Manager) has a PhD in Biomedical Engineering from the Technion, MSc in medical science from the Hebrew University and BSc in Physics and Biology from Bar-Ilan University. For the last 4 years, she was a senior research fellow and lab manager in the vascular surgery department at the University of Washington, Seattle. During her studies, she has gained vast experience in the cardiovascular and neuroscience fields as well as pre-clinical and clinical studies. In the last year she has joined OAL Innovation as medical device project manager.

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OFS is a world-leading designer, manufacturer and provider of optical fiber, fiber optic cable, connectivity, fiber-to-the-subscriber (FTTx) and specialty photonics products. We provide reliable, cost-effective solutions for a broad range of applications including telecommunications, medicine, industrial automation, sensing, government, aerospace and defense. These products help our customers meet the needs of consumers and businesses, both today and into the future. Headquartered in Norcross (near Atlanta) Georgia, U.S.A., OFS is a global provider with facilities in China, Denmark, Germany, Morocco, Russia and the United States. OFS is part of Furukawa Electric Company, a multi-billion dollar leader in optical communications. www.ofsoptics.com

Udo Fetzer (Key Account Manager) is Key Account Manager for Specialty Fiber at OFS. He has 30 years of experience in photonics and fiber optics. He graduated at the University of Kaiserslautern and holds a master in electrical engineering. Before joining OFS in 2017, Udo was working in different product management and business development roles at Hirschmann, JDSU, and Laser 2000. His deep knowledge and experience encompasses passive and active optical components, network systems, optical test and measurement, and fiber sensing. His current focus is developing the business for OFS in EMEA for specialty fibers in medical e.g. laser treatment in urology.

Optosigma offers a variety of products to address the demand of high-quality photonics components. OptoSigma Europe, a subsidiary of SIGMAKOKI, was established in Europe in early 2014 to provide support to our distributors and get closer to the European customers. Our group possesses more than 42 years of experience in manufacturing high quality optics, optomechanical components and optoelectronics systems. Thanks to the rich Japanese know-how we have cultivated over the years, high quality products at an affordable price are available for any customer. Our optics portfolio includes all kind of optics such as high power laser mirrors, beamsplitters, lenses, polarizers, filters among others. Our portfolio also includes a wide variety of opto-mechanics products to hold all kind of optics, as well as motorized and manual stages, optical tables and most of the building blocks for photonics applications. www.optosigma.com

Mauro Persechino (Regional Sales Manager) was born in Rome on 14/11/1984. He started studying Physics at Sapienza University and got his master on quantum information and communication in 2013 after quitting his (very short) football career. For one year, he worked as a Sales Engineer at Crisel Instruments and after thathe got his PhD in France (Paris) on quantum cryptography in 2017. Then, Mauro joined a one-year postdoc on combined Spectroscopy and Microscopy for Quantum Memories. With a wide range of technical knowledge in Optics and a past as Sales Engineer, he join Optosigma as Regional Sales & Application Manager in April 2019.

Philips Research is a global organization that helps Philips introduce meaningful innovations that improve people’s lives. We provide technology options for innovations in the area of health and well-being, targeted at both developed and emerging markets. Positioned at the front-end of the innovation process, we work on everything from spotting trends and ideation to proof of concept and – where needed – first-of-a-kind product development. www.philips.com/a-w/research/about-philips-research.html

Pieter van der Zaag (Principal Scientist)

Politecnico di Torino (POLITO) - founded more than 160 years ago, 35000 students enrolled - is one of the most prestigious public institutions for education, research, technological transfer and services in all sectors of architecture and engineering. Polito, with over 160 H2020 funded projects and 50 partnership agreements with large international enterprises, is a “Research University” that is particularly focused on the balanced development of fundamental and applied research. Photonics is mainly addressed by groups belonging to the Department of Electronics and Telecommunications (DET) and to the Department of Applied Science and Technology (DISAT). These groups have a long experience in developing materials and technological solutions for photonic applications ranging from communications, to materials processing, to biomedicine and to environmental sensing. www.polito.it

Guido Perrone (Professor, head of Fiber and Laser Technologies Group) holds a PhD in Electromagnetics/Photonics and is currently professor of Microwaves and of Optical Components at Politecnico di Torino (Turin’s technical university, Italy). His research interests are in the field of industrial and biomedical applications of Photonics. He is author of more than 200 papers and of the book “Fiber-optic sensors for biomedical applications” and designated as inventor in several patents on fiber sensors and lasers. Guido is member of the Italian Professional Engineers, of the Optical Society of America (OSA), and of the Institute of Electrical and Electronic Engineers (IEEE). Guido is also founder of some start-up companies active in the field of Photonics.

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The Princess Margaret Cancer Centre has 12 site groups and 26 specialty clinics and over 3,000 staff who see over 400,000 patient visits every year. Its 800,000 square feet house 202 inpatient beds, 388,000 square feet of research space and 18 radiation treatment machines, making it one of the largest comprehensive cancer treatment facilities in the world and the largest radiation treatment centre in Canada. Princess Margaret sees over 1,000 patients every day and has the capacity to deliver diagnostic, treatment and follow-up care to close to 200,000 patients and their families every year. In 2015, we saw 18,033 new patients. Among the services provided this year, they delivered 6,206 cancer surgeries as well as 34,851 outpatient chemotherapy treatments, 93,379 courses of radiation treatment and 416 stem cell transplants. Through ongoing research, education and innovation, Princess Marget continues to be on the frontiers of medical, surgical and radiation oncology, embracing the latest technology and international best-practices and setting standards for patient care. www.uhn.ca/PrincessMargaret

Alexandra Easson (Surgeon Investigator) is an academic general surgical oncologist at the Princess Margaret Cancer Centre, University Health Network, in Toronto, Canada and an Associate Professor in the Department of Surgery at the University of Toronto. She graduated from medical school at Queen’s University in Ontario, Canada and completed her General Surgery Residency at the University of Ottawa. She spent 2 years as a Research Fellow at the Massachusetts General Hospital in Boston and completed a Clinical Fellowship in Surgical Oncology at the University of Toronto. She has an MSc in Clinical Epidemiology at the University of Toronto. She manages a busy clinical practice in the management of breast,

melanoma, colorectal and anal malignancies. Her research interests include the study of optical imaging as a diagnostic tool in breast cancer.

Prospective Instruments provides photonic-based multi-modal imaging solutions for research and diagnostics. www.p-inst.com

Lukas Krainer (Founder and CEO) is the founder and CEO of Prospective Instruments since January 1, 2019. From 2017 to 2018, he was Project Manager post merger & acquisition at NKT Photonics. From 2005 to 2017, Lukas was the CEO of Onefive & A.L.S GmbH (sold to NKT).

Christof Böhler (Clinical Research & Diagnostics) is a commercially driven scientist with a proven track record in building and leading teams, which succeed in commercializing life science products and services in the life science industry. His key expertise lies in business development and business management with a focus on technology licensing and selling, as well as fund raising and M&A. Christof is best at selling highly consultative products or services to demanding customers such as research scientists, engineers, medical doctors as well as investors.

Qurin Diagnostics has a mission to save lives and reduce healthcare costs through the development of accessible and easy-to-use diagnostic tests. Together with a strong international network of world leading academic and corporate partners, Qurin develops a revolutionary, low threshold nanotechnology-based platform for non-invasive early diagnosis, monitoring and personalized treatment of cancer and other medical conditions using urine as a liquid biopsy. Current developments are focused on advanced biochip technology using evanescent field-based integrated optics, suitable for multiple biological and biomedical applications. In addition, state-of-the-art bioinformatics algorithms enable the identification of new actionable biomarker panels for a range of medical conditions.www.qurin.com

Coenraad van Kalken (CEO) holds ample experience in managing the technological development and commercial roll-out of innovations in the health and life sciences. He is a medical doctor by training and after working in the clinic for several years, he was appointed director of the New Drug Development Office (NDDO), a research institute specialized in the development of drugs against cancer. During his career, his passion shifted towards the prevention and early diagnosis of diseases and later he decided to dedicate his time and money to this goal. In 2005, after the acquisition of NDDO by INC Research, he founded the Dutch Institute for Prevention and E-health Development (NIPED). With NIPED, he

introduced an innovative, personal approach for detecting health risks and stimulating a healthy lifestyle. The strategic and active management style of Dr. Van Kalken resulted in the successful development of the ‘Personal Health Check’ and the widespread support for the roll-out of this product by the major Dutch health organisations (Public Health Service, the Dutch College of General Practitioners, Heart Foundation, Kidney Foundation, Lung Foundation Netherlands, Diabetes Foundation).

Rakuten Medical is a privately funded, clinical stage Biotechnology company with offices in the USA, Japan and Germany, Taiwan and Netherlands. Since 2013, Rakuten Medical has been developing new anticancer therapies based on the Photoimmunotherapy platform. Rakuten Medical plans to become a fully integrated biopharma with research, development, and world-wide commercialization of therapies based on the Photoimmunotherapy platform with drug and laser optical device technologies. Our long-term objective is to commercialize a number of therapies based on Photoimmunotherapy to treat a broad range of solid tumor types as single agent and in combination with other immunomodulatory agents to generate robust and long lasting anticancer immunological responses. www.rakuten-med.com

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Hiroyuki Kodama (Director of Europe Business Planning, Head of Rakuten Medical Europe) has been leading the corporate & business development in Europe. After finished his PhD program in Molecular Biology at University of Tokyo, he worked for McKinsey & Company with the focus of healthcare industry, and US-based Private Equity fund NovaQuest as a Principal to lead the evaluation of investment opportunities. Hiroyuki currently leading the company’s corporate & go-to-market strategy for Europe, and diversification of Rakuten Medical’s pipeline both for drug and devices.

Hikari Usami (Project Manager) joined Rakuten Medical, Inc., from June 2019 as Project Manager of Europe Business Planning team. Previously she worked incubation business in Rakuten, Inc., one of the Japanese largest conglomerate, and leading their new business launch mainly fintech industry. As part of the Europe Business Planning team of Rakuten Medical, Inc., she is responsible for leading cross-functional initiatives to identify the issues and resolve the corporate level agenda in Europe office and global office. She is currently supporting the company’s European corporate strategy and commercial launch readiness.

RiverD International develops and brings to market dedicated solutions for unmet diagnostic needs, based on Raman spectroscopic analysis of cells and tissues. RiverD's Raman technology platform excels in sensitivity and reproducibility and is readily adaptable to the specific demands of a particular application. The gen2-SCA family of in vivo skin analyzers provides unique insight into the molecular composition of the skin with high spatial resolution, and enables the study of skin penetration properties of topically applied materials. This technology is in use worldwide by personal care industry, pharmaceutical industry and university medical centers. The SpectraCell RA Bacterial Strain Analyzer is RiverD's answer to the need for simple high throughput technology for bacterial typing. At the Erasmus MC in Rotterdam the system is in routine use for rapid analysis of potential outbreak situations and for prospective monitoring of transmission of antibiotic-resistant bacterial strains. www.riverd.com

Gerwin Puppels (Managing Director) is Associate Professor at Erasmus-university Medical Center, Rotterdam, The Netherlands. He is also the Founder, Chief Technology Officer and Managing Director of RiverD International B.V. Rotterdam.

Ryerson is Canada’s leader in innovative, career-oriented education and a university clearly on the move. Located in downtown Toronto, it is a distinctly urban university with a focus on innovation and entrepreneurship. Ryerson has a mission to serve societal need and a long-standing commitment to engaging its community. The most applied-to university in Ontario relative to available spaces, Ryerson's reputation with business and community leaders continues to rise. The university offers more than 100 undergraduate and graduate programs. Urban, culturally diverse and inclusive, Ryerson is home to more than 45,300 students, including 2,600 Master’s and PhD students, 3,800 faculty and staff, and nearly 198,000 alumni worldwide. www.ryerson.ca

Alexandre (Sasha) Douplik (Professor) is a Professor of Department of Physics at Ryerson University since 2011, and also Residential Scientist of St. Michael Hospital, Toronto. In 2007-2011, he was a Guest Residential Professor of Nuremberg-Erlangen University, Germany where he defended his Biomedical Engineering Habilitation (Dr. of Science degree) in 2011. Before 2007, Dr. Douplik was a Senior Scientific Associate at Biophysics/Bioimaging Division in Ontario Cancer Institute (2006-2007) and Senior Researcher of Xillix Technologies Corp., Vancouver (2002-2006). He defended his PhD in Biophysics in 1997. Prof. Douplik is the Head of Ryerson Photonics Group in Physics Department at Ryerson

University. Dr. Douplik is the author of more than 60 peer-reviewed papers, 70 conference papers, 6 book chapters and 14 patents.

Santec is a dynamic, diverse and innovative company at the forefront of the fiber optics industry. In its 40-year history, it has produced the world's fist commercial tunable laser and is proud to now be the largest manufacturer for test & measurement applications. Its swept-wavelength measurement system provides a fast, high accuracy measurement of insertion loss & PDL of waveguides and optical devices. Santec also has a dominant position as supplier of swept-wavelength lasers for Optical Coherence Tomography (OCT) and provides complete OCT measurement systems for a wide range of industrial applications. The company is also recognised as a high quality supplier of optical components, such as tapped photo-detectors, variable attenuators, tunable filters and wavelength selective switches, which are used throughout the telecommunications industry. www.santec.com

David Heard (VP Sales EMEA) is an expert at developing fiber optic test solutions. He received a doctorate in optical materials from Oxford University and subsequently spent 8 years developing optical waveguide technology at Sharp Corporation's research laboratories in Japan. He has spent the last 20 years in the fiber optics industry, in both telecom & biotech, and now leads Santec's European sales activities providing pre and post-sales technical support. He is also responsible for establishing collaborations to create new products & business.

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Scinvivo is a MedTech startup on a mission to enable optical biopsy for bladder cancer diagnostics. We develop imaging catheters based on optical coherence tomography (OCT) that enables physicians to view high resolution cross-sectional images of the tissue and see what exactly is going on inside the bladder wall tissue. In this way, the urologist can see what is going on behind the bladder wall surface and provide a more accurate diagnosis. Patient burden and expenses will decrease as unnecessary operations will not be performed anymore. www.scinvivo.com

Maaike de Jong (CTO) has a background in Biomedical Engineering and obtained her bachelor’s degree at Eindhoven University of Technology, and her master’s degree at Delft University of Technology. She obtained her professional doctorate in engineering (PDEng) at Eindhoven university of Technology, during which she started working on the development of the Scinvivo OCT-catheter. At the beginning of 2017, Maaike spend a five-month internship in Boston at Massachusetts General Hospital to specialize in Optical Coherence Tomography and its endoscopic applications. Since September 2017, she works fulltime for Scinvivo.

SDS Optic is a team of scientists who developed inPROBE, i.e. an innovative project that allows rapid oncological diagnostics. Breast cancer is the most common type of cancer found in women around the world. Approximately 1.7 million new cases of breast cancer and half a million deaths are reported each year. An effective and quick method of detecting the disease could save the lives of many patients, which was the solution created by the SDS Optic team. www.sdsoptic.pl

Paulina Mikolajczuk (Marketing Manager)

SUPERLUM Diodes develops and manufactures low coherent light sources based on semiconductor superluminescent diodes (SLD) and driving electronics in 650-1620 nm spectral range, as well as semiconductor optical amplifiers (SOA) and tunable swept light sources (SS) in 750-1100 nm spectral range. SUPERLUM products are used by over 250 companies worldwide in various applications: Optical Coherence Tomography (OCT), Fiber-Optic Sensing and Metrology, Non-Destructive Testing (NDT), Fiber-Optic Gyros, Speckle Free Illumination and others. Our R&D group can design complete opto-electronic systems for your application. www.superlumdiodes.com

Natalie Tuchapsky (Director of Sales and Marketing) has been instrumental in establishing the European branch of SUPERLUM, operating out of Ireland, since 2000. Natalie is a graduate of Moscow University with a Master's Degree in Physics, and has been rounding off her academic foundation with certification in Business Management, Finance and Digital Marketing. The comprehensive business approach has allowed her to build a robust cooperative relationship with Irish Industrial Development Authority, and have the company achieve ISO certification. Her current focus is on optimising company processes and continuing to expand and support the company customer base.

TechMed Centre at the University of Twente is an interfaculty Institute acting as a leading Innovation Hub impacting healthcare by excellent Research, Innovation and Educational programs. It is equipped with state-of-the-art infrastructure, ranging from research labs, preclinical testbeds and simulated hospital environments. Our mission is to improve healthcare by personalized technology with societal impact. We stimulate entrepreneurship and enable (new) companies to grow within our regional ecosystem, and collaborate with industry, hospitals, governments and insurance agencies on the development of new solutions for healthcare. www.utwente.nl/en/techmed

Rudolf Verdaasdonk (Professor) is full professor of Health Technology Implementation in the TechMed Centre at the University of Twente and staff member the Biomedical Photonics Imaging group. Before, he was head and chair of the department of Physics and Medical Technology at the Amsterdam University Medical Center (VUmc). He received his MSc in Applied Physics at the Technical University Eindhoven in 1985 and his PhD in Medicine at the University Medical Center Utrecht in 1990. He has been working in University Medical Centres for over 30 years as a registered Clinical Physicist. His research interest and expertise is in a broad range of surgical equipment and imaging modalities.

He is using ‘smart devices’ for monitoring vital functions and diagnostics. He has developed special imaging techniques to study the interaction of equipment with the patient in view of safety, treatment quality and development of new applications. He is working in close collaboration with the clinical professionals. He is active in patient safety, innovation and valorisation of new medical technology with several patents and devices being commercialized. He authored over 150 papers, proceedings and book chapters.

Tematys provides a complete range of services to companies and public organizations in the fields of optics, photonics, sensors and material Engineering. Our clients are companies of any size, from international groups to SMEs and start-up. We have also developed a special expertise in R&D valorization and marketing of emerging technologies for Research Organizations and Laboratories. We provide strategic views on optics and photonics markets for publics for clusters and publics agencies. www.tematys.com

Jacques Cochard (Founder) founded in 2010 TEMATYS, a photonics dedicated market studies company. He is managing the activities of Market Exploration for new technologies and Technology Transfer into commercial ventures. Jacques is directly in charge of the Biophotonic activities at TEMATYS where he has advised many companies in their diversification from e.g. Telecom components to Biophotonics market. He is advisor for SMEs and large companies in their development into various application like Superresolution, Confocal as well as Raman imaging market and in Biomedical markets like medical lasers, Photoacoustic, OCT and diffuse optical tomography imaging. Since 10 years,

Jacques is a member of the WorkGroup Biophotonic in the European platform Photonics21. He graduated from Ecole des Mines Nancy (Material science).

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The Tyndall National Institute, University College Cork, is one of Europe’s leading centres for Information, Communications and Technology: ICT research and development. It is the largest facility of its kind in Ireland. Tyndall, formally known as the National Microelectonics Research Centre, was established in 2004 to provide a critical mass of researchers that would support the growth and development of a smart knowledge based economy in Ireland. www.tyndall.ie

Stefan Andersson-Engels (Head of Biophotonics) graduated in Engineering Physics from Lund University in 1985, and received his PhD in Physics from Lund University 1990. He was then a postdoc at McMaster University in Ontario, Canada 1990-1991. After a few years as lecturer, he was appointed professor in 1999 at Lund University. Dr Andersson-Engels has published extensively in the area of biomedical optics, with 200 papers in peer-reviewed journals and an h-index of 62 (Google Scholars). His main interest is optical spectroscopy and acousto-opics, and in light propagation in turbid media. He is involved in three start-up companies.

Ray Burke (Senior Technology Manager) has a background in Physics and Electronics and holds a research master’s degree in physics in the biomedical application area. He has more than 25 years R&D experience in the ICT and MedTech industries working for large multinational corporations (including Boston Scientific) as a senior design engineer and a research manager. He also worked as program manager for ICT for health in Tyndall for four years. His experience is in application areas such as cardio rhythm management (CRM), system level medical device design, RF and wireless communications, photonic sensors & integration, CMOS camera/image sensors, medical device design and

test, biophotonics and electronic circuits. He has 11 patent applications and has worked in an FDA/CE regulated manufacturing environment and with KOL clinicians for next generation medical device design and translation. He engages with clinicians and has a wide network of collaborators and attends surgery, animal and cadaver trials. Ray leads the engagements with medical device companies, including the technical programmes, and clinician engagements.

TNO is an independent Dutch organization for applied scientific research. TNO connects people and knowledge to create innovations that boost the sustainable competitive strength of industry and well-being of society. This mission drives us, the 2,600 professionals at TNO.

The need for more, better and affordable medical care is increasing. We use light to diagnose diseases earlier and in a harmless way based on the ‘optical fingerprint’ of disease processes. As a result, treatments can start earlier and are more effective, providing better outcomes at lower costs. TNO has a focus on the development and clinical validation of new optical diagnostic instruments based on light transport in biological tissues. A good understanding of how light behaves in tissues makes it possible to convert measured optical signals into parameters that are of diagnostic value. www.tno.nl

Michiel Oderwald (Senior Business Developer) graduated at Delft University of Technology as a mechanical engineer on the field of medical instruments. As a business developer in the field of medical devices, I help create collaborations with our existing and new partners in order to bring medical innovations to the market.

TU/e Institute for Photonic Integration (IPI) was established on April 25th 2016. It integrates all research areas crucial to photonics - materials and devices, components, circuits, systems ¬- and cooperates with initiatives that bring photonic research results to a higher Technology Readiness Level. The Institute for Photonic Integration is a leading R&D center in the field of photonics. The work of the institute ranges from fundamental scientific research to the development of prototypes that are taken on to the product stage by industry. The Institute for Photonic Integration continues the research of the TU/e research school COBRA, and therefore possesses an extensive staff of researchers along with a large cleanroom(800 m2) optimized for photonics R&D. The research school has been one of the world’s leading proponents of photonics research for many years. Furthermore, there is intensive collaboration on photonics with the research groups of the University of Twente and Delft University of Technology. The institute covers three fields: photonics materials (III-V semiconductors), integrated circuits (photonic integrated circuits, PICs) and photonic systems. www.tue.nl/en/research/research-areas/integrated-photonics

UC Davis is the home of the Aggies — go-getters, change makers and problem solvers who make their mark at one of the top public universities in the United States. Since we first opened in 1908, we’ve been known for standout academics, sustainability and Aggie Pride as well as valuing the Northern California lifestyle. These themes are woven into our 100-plus-year history and our reputation for solving problems related to food, health, the environment and society. Our 5,300-acre campus is in the city of Davis, a vibrant college town of about 68,000 located in Yolo County. The state capital is 20 minutes away, and world-class destinations such as the San Francisco Bay Area, Lake Tahoe and the Napa Valley are within a two-hour drive. www.ucdavis.edu

Julien Bec (Engineering and Operations Director) is a graduate of Centrale Lyon and Politecnico di Torino with a master’s degree in Automotive Engineering. After several years as an R&D engineer in the automotive industry (active chassis systems, emissions control), he joined the UC Davis Biomedical Engineering department working on the design, fabrication, and evaluation of biomedical imaging systems in the nuclear and optical imaging fields. His current activity is focused on the development and clinical validation of fluorescence lifetime instrumentation for cardiovascular and oncology applications. As such, he is supervising hardware and software developments, clinical study design,

development of data analysis methods, and compliance activities for the "Optical Spectroscopy for Disease Diagnosis" laboratory, under Pr. Laura Marcu.

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University of Exeter is a top UK university which combines world leading research with very high levels of student satisfaction. It is one of the UK’s most popular and successful universities with campuses in Exeter, Devon, and near Falmouth in Cornwall. Exeter is ranked 10th out of more than 100 UK universities in the Times league table. Exeter is one of the top 150 universities in the world according to the Times Higher Education's World University Rankings. Exeter has been shortlisted for the Sunday Times University of the Year Award more times than any other university and has won three Queen’s Anniversary Prizes for its research. www.exeter.ac.uk

Nick Stone (Professor) holds the position of Professor of Biomedical Imaging and Biosensing and Head of Physics and Astronomy at the University of Exeter. Nick has worked to pioneer the field of novel optical diagnostics within the clinical environment, moving from the National Health Service (Gloucestershire Hospitals), in 2012 after almost 20 years of working closely at the clinical/academic/commercial interface to pull-through novel technologies to be used where they have most clinical need. He is an internationally recognised leader in biomedical applications of vibrational spectroscopy (Raman and IR). Nick has received numerous awards for his research both personally and within his

research group. He recently won the 2014 International Raman Award for ‘Most Innovative Technological Development’ and was runner up in the 2013 NHS Innovation Challenge Prize. He won the UK Chief Scientific Officer’s National R&D Award for 2009. He has published over 150 papers and book chapters.

Urorad Concept is a Swiss multidisciplinary specialist prostate care group. We offer dynamic alternative consultations to assist prostate cancer patients. We accompany our patients from diagnosis all the way to treatment with an individual and human approach. www.uroradconcept.com

Stefano Regusci (Urologist) received his early education in Lugano and then conducted his medical studies in Geneva and obtained his medical degree in 1990. He began his career as a resident in the Department of General Surgery at the Hôpital d’Aigle (1991-1993), then at the Hôpital de Bellinzona (1994-1995) and finally at the Urology Clinic of the Geneva University Hospital (1995-2001), with Prof. Graber and Prof. Iselin. In 2000, Dr. Regusci obtained his doctorate and the title Specialist in Urology FMH (Swiss Medical Association). From 2000-2001, he worked as Senior Registrar in the Urology Department led by Prof. Iselin. Dr. Regusci has a keen interest in sacral neuromodulation for overactive bladder,

urodynamics, focal therapy of prostate cancer, urological and radiological diagnosis of prostate tumours, as well prostate hypertrophy with various alternative therapies to conventional surgery. With Martina Martins, radiologist, he founded in 2017 Urorad Concept, a society working in the field of prostate cancer, offering second advice, teleradiology help in the treatment of prostate cancer and in the creation and developpement of a Prostate Cancer center. He is an active member of many national and international scientific societies. The mission of the Swiss lnternational Prostate Center

(SIPC) is to provide care for patients from diagnosis to treatment, in malignant or benign prostatic disease, in accordance with medical ethics, which guarantees the quality of care. For this, the SIPC has a medical team of highly experienced certified urologists and radiologist including some of the pioneers of robot-assisted surgical techniques.

USHIO has garnered a worldwide reputation as the leading manufacturer of speciality industrial light sources. Spanning the complete spectrum of wavelengths, from the extremities of UV and visible light right through to infrared and SWIR, USHIO solutions can be found in a diverse range of products. Next to lamps and devices USHIO offers a wide range of high-quality Laser Diodes and LEDs - all wavelengths in the UV, visible and IR spectra between 365nm and 1,750nm – for all applications. www.ushio.com

Jonatan Klee (Sales Manager) has 8 years’ experience in LED market including marketing and sales positions. He has almost 5 years of it mainly focused on UV LED. Jonatan has been working for Ushio as a sales manager since 201. He has been working in the LED & Laserdiode division specialised on industrial sensing/illumination and medical & biomedical applications. He is also studying oeconomincs beside work at Euro FH in Hamburg.

V&A-Photonics co-develops and markets photonics integrated solutions for telecom, data communications, and sensing applications. We also, offer R&D services for customers who would like to develop their own products. Operating from offices in Eindhoven in the Netherlands and Wuxi in China we link Photonic integrated systems end users with technology developers. If you are a product supplier searching for co-developer V&A-Photonics is your ideal partner.www.va-photonics.com

Sami Musa (CTO) obtained a PhD in integrated optics from Twente University in the Netherlands in 2003. Following his graduation, he took several research positions in academic and industrial institutions including Technical Universities of Delft and Eindhoven in the Netherland, University of Limerick in Ireland and ASML. In 2011, he Joined Vision and Actions as a CTO. In 2017 he co-founded V&A-Photonics, a company active in photonic business development between Europe and China. Currently, he serves as CTO of V&A-Photonics. Dr. Musa has 18 US and International patents and co-authored more than 30 scientific papers.

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VALO Innovations offers innovative fiber-based, ultrashort pulse laser systems with durations below 50 fs at a range of power levels. The simple, user-friendly, turnkey laser systems are controlled by "intelligent" electronics. Our systems can be used for various applications in biophotonics (e.g. multiphoton microscopy), micro- and nanomaterial processing, scientific applications and many more. With more than 12 years of experience in fiber lasers and amplifiers we create innovative solutions, tailored for our customers. www.valo-innovations.com

Oliver Prochnow (CEO & Co-Founder) studied physics at the Leibniz University of Hannover (Germany). He did his diploma thesis and PhD at the Laser Zentrum Hannover. Afterwards, he became Director of Research & Development at Venteon Laser Technologies for 7 years. In 2018, he founded VALO Innovations GmbH together with Alexander Pape. Up to now, he has more than 12 years of experience in the field of ultrafast fiber technologies.

Yelo, founded in 1983, specialise in the design and manufacture of burn-in and life test equipment for optoelectronic devices. With an experienced team of 50, Yelo has grown to become one of the industry’s leading and most trusted names for burn-in equipment. The company is vertically integrated and possesses full design and manufacturing capabilities. One of Yelo’s biggest strengths is its in-house mechanical design capability which looks after device fixturing and probing for many different types of devices (bare chip, laser bar, chip on carrier, chip on substrate and packaged devices). Another key strength is its Research and Development division which provides solutions for complex issues such as thermal management. By having early discussions in the design phase of a new photonics device, Yelo can advise a suitable approach needed to enable safe, repeatable device testing. www.yelo.co.uk

Dylan Burke (Marketing Manager) obtained a first class honours degree in Marketing from Ulster University in 2016 and officially holds the title as the highest ever performer on the degree programme winning 3 consecutive Marketing Excellence Awards in 2014, 2015 and 2016. He joined Yelo in 2016 and is responsible for all the Marketing activities in the company including; generating new business opportunities, PR, branding, managing the website and organising Yelo’s appearances at various Photonics exhibitions throughout the year including; Photonics West, OFC, ECOC and CIOE.

The European Technology Platform Photonics21 represents over 3000 members of the photonics community coming from industry and science. Photonics technology is integral to a wide range of industries including medical, healthcare, transport, manufacturing and telecommunications sectors and – according to the EU Investment Bank “one of these essential key enabling building blocks for the digital transformation of Europe”. www.photonics21.org EPIC – European Photonics Industry Consortium, representing over 500 corporate members, is the world leading industry association that promotes the sustainable development of organizations working in the field of photonics. EPIC fosters a vibrant photonics ecosystem by maintaining a strong network and acting as a catalyst and facilitator for technological and commercial advancement. www.epic-assoc.com

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