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Copyright © 2017 the authors
This Accepted Manuscript has not been copyedited and formatted. The final version may differ from this version.
Research Articles: Behavioral/Cognitive
Episodic memory retrieval benefits from a less modular brain networkorganization
Andrew J. Westphal1, Siliang Wang1 and Jesse Rissman1,2,3,4
1Dept of Psychology2Dept. of Psychiatry and Biobehavioral Sciences3Brain Research Institute4Integrative Center for Learning and Memory, University of California Los Angeles, Los Angeles, CA 90095
DOI: 10.1523/JNEUROSCI.2509-16.2017
Received: 20 June 2016
Revised: 14 February 2017
Accepted: 17 February 2017
Published: 27 February 2017
Author contributions: A.J.W. and J.R. designed research; A.J.W. performed research; A.J.W. and S.W.contributed unpublished reagents/analytic tools; A.J.W. and J.R. analyzed data; A.J.W. and J.R. wrote thepaper.
Conflict of Interest: None
Funding for this research was provided by the UCLA Division of Life Sciences. AJW was supported by a UCLANeuroImaging Training Program Fellowship sub-award from NIH (5R90DA023422-10). We are extremelygrateful to Martin Monti for his provision of scripts for implementing the graph theoretical analyses, guidance oninterpretation of the results, and insightful feedback on an earlier version of this manuscript. We also thank NiccoReggente for assistance with data processing and analysis.
Corresponding Author: Andrew J. Westphal, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095-1563,Phone: (310) 825-2961 Fax: (310) 206-5895, Email: [email protected]
Cite as: J. Neurosci ; 10.1523/JNEUROSCI.2509-16.2017
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Participants
Procedure
1) Remember One of the Words from
SELF Context, 2) Remember One of the Words from OTHER Context, 3) Recognize
One of the Words, But Don’t Recall Source, 4) All Words are Novel
1) Valid Analogical Relationship, 2) Two Valid Semantic
Relationships, 3) One Valid Semantic Relationship, 4) No Semantic Relationships
1) Top Left Word
has the Most Straight Lines, 2) Bottom Left Word has the Most Straight Lines, 3) Bottom
Right Word has the Most Straight Lines, 4) Top Right Word has the Most Straight Lines.
MRI Data Acquisition and fMRI Preprocessing
Task-specific Functional Connectivity Estimation
Graph Theoretic Analysis
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Behavioral Results
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Task-dependent Changes in Global Connectivity
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FPCN and DMN Coupling with Hippocampus
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