/

smansouri @ kmu.ac.ir

ESBL

ESBLDCDTdouble disc test &

combined disc test

ESBL

ESBL

Extended Spectrum -Lactamases: ESBLs

ESBL

EMBc

TSIOF

ONPGDNase

TSB

g/ml

g/mlMAST

Minimum

Inhibitory concentration: MIC

CLSI

(MAST)

comcombined disc

double disc test+ combined disc)(DCDT:

DCDT

MAST

ESBL

ATCC ATCC

KOAS

PER-1 TEM

.

SPSS=18

(Chi-square)

/P

(MIC)

MIC(µg/ml)

ESBL

Ac CTXCAZCPDCPM

CNCAZ/CV

/P

MDR

DCDT

ESBL

ESBL

ESBL

ESBL

ESBL

/P

/

.

Giske

MDR

/P

Malini

AbaR1

L1

L1

L2

Aibinu

Al-NaiemiDCDT

ESBL

ESBL

ESBL

ESBL

MIC

ESBL

ESBL(P 0.01)

MDR

MDR

ESBL

1.Clinical and Laboratory Standards Institute. Methods for dilution antimicrobials susceptibility tests for bacteria that grow aerobically. Approved standard 6th edition.CLSI document M7-A7. Wayne,PA.2006. 2. Malini A, Deepa EK, Gokul BN , Prasad SR. Nonfermenting gram negative bacilli infections in a tertiary care hospital in Kolar, Karnataka. J Lab Physicians 2009:1(2):62-66.

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impact of common multidrug-resistant gram-negative bacilli. Antimicrob Agents Chemother. 2008;52(3):813-821.

16. Ekrami A, Kalantar E. Bacterial infections in burn patients in at a burn hospital in Iran. Indian J Med Res 2007;126:541-544. 17.Maragakis LL, Perl TM.Acinetobacterbaumannii: epidemiology, antimicrobial resistance, and treatment options. Clin Infect . Dis 2008; 46:1254-1263. 18. Fournier PE ,Vallenet D, Barbe V, Audic C, Ogata H, Poirel L.Comparative genomics of multidrug resistance in Acinetobacter baumannii.PLOS Gen. 2006;2(1): 0062- 0071. 19. Avison MB, Higgins CS, Ford PJ, Von Heldreich CJ, Walsh TR, Bennett PM, et al. Differential regulation of L1,L2 beta-lactamase expression in Stenotrophomonas maltophilia. J Antimicrob Chemother 2002;49(2):387-389. 20. Aibinu A, Nwanneka T, Odugbemi T. Occurrence of extended-spectrum -lactamase and MBL in clinical isolates of Pseudomonas aeruginosa from Lagos,Nigeria. J Am Sci. 2007;3(4):81-85. 21.Pool K.Efflux-mediated multi resistance in Gram-Negative bacteria .Clin Microbiol. Infect 2004;10(1):12-26.