fast casters – project update march 16, 2006
DESCRIPTION
Fast Casters – Project Update March 16, 2006. Rene Chen Byron Hsu Kimberly Kam Kelsey Vandermeulen Lisa Witmer. Powder Formulation Components. PCL: polycaprolactone C 6 H 10 O 2 PLGA: poly(lactide-co-glycolide) (C 6 H 8 O 4 ) x (C 4 H 4 O 4 ) y TCP: tricalcium phosphate Ca 3 (PO 4 ) 2 - PowerPoint PPT PresentationTRANSCRIPT
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Fast Casters – Project Fast Casters – Project UpdateUpdate
March 16, 2006March 16, 2006
Rene ChenRene Chen
Byron HsuByron Hsu
Kimberly KamKimberly Kam
Kelsey VandermeulenKelsey Vandermeulen
Lisa WitmerLisa Witmer
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Powder Formulation Powder Formulation ComponentsComponents
PCL: polycaprolactonePCL: polycaprolactone CC66HH1010OO22
PLGA: poly(lactide-co-glycolide)PLGA: poly(lactide-co-glycolide) (C(C66HH88OO44))xx(C(C44HH44OO44))yy
TCP: tricalcium phosphateTCP: tricalcium phosphate CaCa33(PO(PO44))22
HA: hydroxyapatiteHA: hydroxyapatite CaCa55(PO(PO44))33OHOH
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Update from Formal Design Update from Formal Design ReviewReview
Modulus ranges for individual Modulus ranges for individual materialsmaterials PCL: 0.5-1 GPaPCL: 0.5-1 GPa PGA: ~8 GPaPGA: ~8 GPa PLA: 2-3 GPaPLA: 2-3 GPa HA: 7-13 GPaHA: 7-13 GPa
Modulus for scaffold structuresModulus for scaffold structures ~0.001 GPa~0.001 GPa
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Initial GoalsInitial Goals
Characterize Characterize current current compositioncomposition 30% sucrose30% sucrose 30% lactose30% lactose 20% TCP20% TCP 20% PLGA20% PLGA
Solid structuresSolid structures
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Solidworks Test SamplesSolidworks Test Samples
Drew up SolidWorks filesDrew up SolidWorks files Printed tension Printed tension
specimensspecimens
CompressionCompression
TensionTension
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Mechanical TestingMechanical Testing Used Yin Lin’s InstronUsed Yin Lin’s Instron Automatic gripsAutomatic grips
Controlled by air Controlled by air pressurepressure
Too high Too high
Manual gripsManual grips Work for our samplesWork for our samples Noisy, inaccurate dataNoisy, inaccurate data
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Young’s Modulus: E = Estress/Estrain Young’s Modulus: E = Estress/Estrain = 280 KPa= 280 KPa
Failure Stress = 26.6 KPaFailure Stress = 26.6 KPa Yield Stress = 20.9 KPaYield Stress = 20.9 KPa
Engineering Stress Engineering Stress = force/area = force/area
Engineering Strain Engineering Strain = displacement / = displacement / original lengthoriginal length
Instron Test ResultsInstron Test Results
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Future Mechanical Testing Future Mechanical Testing CandidatesCandidates
Look at different methods of testingLook at different methods of testing NanoindentationNanoindentation
Problematic microstructureProblematic microstructure Would need too large of an indenterWould need too large of an indenter
3- or 4- point bending tests3- or 4- point bending tests Will not reduce materials usageWill not reduce materials usage
MicroTester InstronMicroTester Instron Best optionBest option
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MicroTester InstronMicroTester InstronMechanical TestingMechanical Testing
MicroTester benefitsMicroTester benefits Smaller load cell Smaller load cell
(10N)(10N) Smaller sample size = Smaller sample size =
less materials and less materials and printing timeprinting time
Automated as Automated as opposed to manualopposed to manual
Made appt. to test Made appt. to test next week (thanks to next week (thanks to Alan Schwartzman)Alan Schwartzman)
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SEM ImagingSEM Imaging
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X-Ray X-Ray SpectraSpectra
PGLA
Tricalcium Phosphate
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Additional ProgressAdditional Progress
Polymer dispersion Polymer dispersion process process Started on PCLStarted on PCL
Received HA orderReceived HA order Placed order for Placed order for
beta-TCPbeta-TCP
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Next StepsNext Steps
Test more samplesTest more samples Tension and Tension and
compressioncompression A range of formulations A range of formulations
(using HA)(using HA) SolidWorks test files SolidWorks test files
for MicroTesterfor MicroTester MicroTester testingMicroTester testing Waffle structure in test Waffle structure in test
specimensspecimens
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Project TimelineProject Timeline
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Questions?Questions?