fenicoles en avicultura
DESCRIPTION
Florfenicol Farmacocinética del florfenicol Mecanismo de acción de fenicolesTRANSCRIPT
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Apasionados por la salud animal
Fenicoles en avicultura
Fenicoles en avicultura
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H C
HH H
H H
HH
N
C C C
C C C
3 2
2lO
OSO
O N
H H H
H H
HH
O
O
O
C C C
CCC
N
2 2
2l
H
H
H H H
H
H
C C C
CCC C
O
O
O
N
2
2
3 S
lO
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Niveles medios plasmáticos de �orífenicol tras dosis única intravenosa de 20 mg/kg en pollos de engorda.
100
10
1
0,1
0,01
0 5 10 15 20 25
Tiempo
ug/ml
Niveles medios plasmáticos de �orfenicol y de su metabolito �orfenicol amina tras dósis única oral de 20 mg �orfenicol/kg en pollos de engorda
�orfenicol �orfenicol amina
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Niveles medios plasmáticos tras dosis única intravenosa yoral de 20 mg �orfenicol/kg en pollos de engorda
i.v., �orfenicol
oral, �orfenicol
oral, �orfenicol amina
Niveles medios tisulares (�orfenicol + �orfenicol amina)tras dosis oral de 20 mg �orfenicol/kg/día, durante
3 días, en pollos de engorda
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Sitio A
Sitio B
ARNt
ARNm
Florfenicol 30 mg/kg 55.329Cloranfenicol 30 mg/kg
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Tejido 24 Horas 5 Días Musculo 511.17 +- 241.01 μg/ml 70.50 +- 17.87 μg/ml
Riñon 612.84 +- 99.40 μg/ml 362.00 +- 71.89 μg/ml Piel- Grasa 771.83 +- 100.24 μg/ml 148.83+-10.59 μg/ml
Hígado 2,318.67 +- 142.16 μg/ml 1,058.17 +- 126.60 μg/ml
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Actividad comparada de cloranfenicol, tianfenicol y �orfenicol frentea bacterias resistentes ( NEU y KWUNG, 1989)
Microorganismo Cloranfenicol
CMI ( ug/ml)
Tianfenicol Florfenicol
Escherichia coli
Enterobacter cloacae
Klebsiella pneumonise
Providencia
Sreptoccocus marcescens
Pseudomonas aeruginosa
Salmonella typhimurium
Proteus rettgeri
Proeus vulgaris
Acinetobacter
Shigella sonnei
Citrobacter freundii
Staphylococcus aureus
Bacteroides melaninogenicus
Salmonella typhi
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>100
100
100
100
100
100
100
100
200
200
200
200
200
200
200
200
200
200
200
200
200
200
200
200
200
200
200
200
200
200
50
50 50
3,1
3,1
3,1
3,1
3,1
3,1
12,5
12,5
12,5
12,5
12,5
12,5
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Actividad de �orfenicol frente a cepas resistentes a cloranfenicol a niveles de 25 ug/ml (NEU y KWUNG, 1989).
Microorganismo (N)
E. coli (11)
Shigella (4)
Klebsiella (13)
Enterobacter (2)
Salmonella (7)
Citrobacter (2)
Providencia (20)
Pseudomonas (7)
Acinetobacer (8)
S. aureus (3)
Enterococcus (1)
Bacteroides (2)
% Resistencia
Florfenicol
18
0
46
100
0
50
25
100
100
0
0
0
(N) N de aislados
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TianfenicolFlorfenicol
0.18 - 0.830.48 - 2.07
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Salmonella sppStaphylococcus spp
Haemophilus sppManhemia haemolytica
Pasteurella multocidaEscherichia coli
0.8-2 ug/ml1-4 ug/ml0.5 ug/ml0.5-1 ug/ml0.5 ug/ml0.8 ug/ml
Bacteria CMI en ug/ml
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Tejido 24 horas 5 días 7 dias Hepático 687.34 +- 94.77 μg/ml 267.00 +- 56.57 μg/ml 69.50 +- 14.07 μg/ml
Renal 637.17 +- 72.72 μg/ml 221.00 +- 60.12 μg/ml 51.67 +- 19.45 μg/ml Piel - Grasa 255.50 +- 71.57 μg/ml 44.84 +- 10.19 μg/ml No detectado
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Tejido Días Muscular 7.56
Piel + Grasa 8.36 Hepático 3.02
Renal 5.6
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0 10 20 30 40 50 60Tiempo (horas)
Conc
entr
ació
n pl
asm
átic
a ( u
g/m
l) 3.0
2.5
2.0
1.5
1.0
0.5
0.0
�orfenicol de referencia�orfenicol genérico 1�orfenicol genérico 2
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