Nelson OrigaPharm.D. Candidate TTUHSC Schoolof Pharmacy

List examples of fluoroquinolones Describe common uses fluoroquinolones Describe drug-drug and drug-food interactions Name common side effects of fluoroquinolones Educate a patient on fluoroquinolones

Ciprofloxacin Cipro®

Common dose 500mg PO q 12 hours

Levofloxacin Levaquin®

common dose 500mg -750mg PO, IV q 24 hours

Moxifloxacin Avelox®

Norfloxacin Noroxin®

Ofloxacin Floxin®

Besifloxacin Besivance®

Gemifloxacin Factive®

Pneumonia

UTI

Prostatitis

GI and Abdominal Infection

Susceptible gram-/+, atypical, mycobacteria

Antacids Multivitamins Dairy products Juice-Ca++

Ca

Cipro + Zanaflex = ↓BP + ↑Sedation

Levaquin

↑ Drowsiness

Watch

Warfarin: Increased effect NSAIDs: ↑CNS Stimulation and Seizures Sucralfate: ↓ Absorption of Cipro, Levaquin Methadone: ↑ Levels of methadone Amiodarone: Faster heart beat

GI: Nausea, vomiting, diarrhea Rash with prolonged use and with NSAIDs Headache, lightheadness,dizziness aggravated by

NSAIDs Achilles tendon rupture if >60yo + Steroids QT interval increase → increased heart rhythm

Tendonitis Tendon rupture Myasthenia gravis

Take with adequate amount of fluids Take full course of therapy even if you feel better Monitor any bothersome side effects such as

diarrhea and report to MD Monitor signs/symptoms for improvement Take dairy products, MV, Antacids separately

Cipro 250mg @ $0.13 500mg @ $0.06

Levaquin 250mg @ $0.10

500mg @ $0.18 750mg @ $0.27

Thanks: Dr. Raj