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SCIENTISTS DISCOVER NEW DETAILS OF BIOCHEMICAL INTERACTIONS NECESSARY

FOR CELL DIVISION AND

BCM SCIENTISTS UNRAVEL MYSTERY BEHIND DNA BREAKS IN

RESTING CELLS

Daniela Martínez LaverdeMedicine student

U.P.B

FOLDING

Basing on the DNA duplication process determine a missing link about what happens to helicase enzyme before unwinding DNA in two strands

Know how broken strands of DNA occur without any outside intervention

Scientists discover new

details of biochemical interactions

necessary for cell division

Published on July 15, 2013

Origin recognition complex (ORC)

The DNA replication ORC is a six-protein machine with a slightly twisted half-ring structure (yellow). ORC is proposed to wrap around and bend approximately 70 base pairs of double stranded DNA (red and blue). When a replication initiator Cdc6 (green) joins ORC, the partial ring is now complete and ready to load another protein onto the DNA. This last protein (not shown) is the enzyme that unwinds the double stranded DNA so each strand can be replicated.

"Every cell starts to replicate its genome at defined DNA places called 'origins of replication,'” "A cell finds those origins in its vast genome with a protein 'machine' called the 'origin recognition complex,' or ORC."

I think there are still many details to know, but thanks to the people who do this

kind of research we are getting closer to knowing

and understanding things we cant even imagine, In

addition is good that the new discoveries can help

people who most need it, as in this case enabling new

ways to fight cancer

BCM SCIENTISTS UNRAVEL MYSTERY BEHIND

DNA BREAKS IN RESTING

CELLS

Published on July 17, 2013

✔ Researchers able to make DNA breaks with extraneous procedures✔ Now able to make DNA breaks without any outside intervention

Responsible for unzipping the DNA molecule

Temporarily bind to each side of the replication fork, keeping the two strands of DNA separate.

Moves down one side of the open DNA and adds new

complementary nucleotides to replicate one DNA strand

BREAKS OCCUR WHEN DNA IS REPLICATING

•The unzipping process allows for opportunities DNA breakage

• When the RNA polymerase collides with replication machinery occurs DNA breakage

BREAKS OCCUR WHEN DNA IS NOT REPLICATING

Hybrid RNA-DNA structures that have demonstrated to be precursors of mutagenesis

Produce double-strand breaks

Loops that results from RNA-DNA hybrids are more widespread under stress conditions such as starvation, the genomes in stressed cells have “hot spots" for mutation.

Probably in a few years, it will be possible to reprogram the DNA strand breaks that are not replicated and those who do to avoid problems of destabilization of the genome, production of cancer and antibiotic resistance

With their findings, possibly can get new ways to fight cancer and give back hope to those who possess it.

U T I L I T YMED I C A L

U T I L I T YMED I C A L

Enables to understand to the entire medical community, investigators and students about essential biological processes such as the details of the mechanism of DNA replication.

Y

M E D I C A L

U T I L I TBroken strands of DNA can be a real problem, but if they can find ways to repair or lessen the damage, it would be useful to avoid destabilization of the genome, generation of cancer and resistance to antibiotics.

M E D I C A L

U T I L I YTKnow the utility of DNA as genetic material is important for understanding a huge part of the biological sciences, Modern life is deeply influenced by science and technology, for this reason is very important to use these types of studies and learn more about the new processes that have been discovered.

• MARTINEZ SÁNCHEZ, Lina María. Molecular biology. 7. ed. Medellín: UPB. Fac. of Medicine, 2013. 57,81 pg.

• News medical. “Scientists discover new details of biochemical interactions necessary for cell division” Published on July 15, 2013 DOE/Brookhaven National Laboratory. [http://www.news-medical.net/news/20130715/Scientists-discover-new-details-of-biochemical-interactions-necessary-for-cell-division.aspx]

• Bionews Texas. “BCM Scientists unravel mystery behind DNA breaks in resting cells” Published on July 17, 2013. [http://bionews-tx.com/news/2013/07/17/bcm-scientists-unravel-mystery-behind-dna-breaks-in-resting-cells/]

• Brookhaven science. “Study Reveals How Protein Machinery Binds and Wraps DNA to Start Replication” Published on March 6, 2012. Media & Communications Office. [http://www.bnl.gov/newsroom/news.php?a=11391].

Bibliography

Thank you…