foxp2 variation in great ape populations offers insight ... › esm › art:10.1038... ·...

Supplementary information

FOXP2 variation in great ape populations offers insight into the evolution of communication skills Nicky Staes1,*, Chet C Sherwood1, Katharine Wright2, Marc de Manuel3, Elaine E Guevara1, Tomas

Marques-Bonet3,4,5, Michael Krützen6, Michael Massiah2, William D Hopkins7,8 John J Ely9 and

Brenda J Bradley1

1 Center for the Advanced Study of Human Paleobiology, Department of Anthropology, The

George Washington University, 800 22nd Street NW, Suite 6000, Washington, DC, 20052, USA 2 Department of Chemistry and Center of Biomolecular Science, The George Washington

University, 800 22nd Street NW, Washington, DC, 20052, USA 3 Institute of Evolutionary Biology (UPF-CSIC), PRBB, Dr Aiguader 88, 08003 Barcelona, Spain 4 Catalan Institute of Research and Advanced Studies (ICREA), Passeig de LIuis Companys 23,

08010, Barcelona, Spain 5 CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and

Technology (BIST), Baldiri I Reixac 4, 08028 Barcelona, Spain 6 Evolutionary Genetics Group, Department of Anthropology, University of Zurich,

Winterthurerstrasse 190, CH-8057 Zurich, Switzerland 7 Neuroscience Institute, Georgia State University, 33 Gilmer Street SE, Atlanta, GA, 30322, USA 8 Division of Developmental and Cognitive Neuroscience, Yerkes National Primate Research

Center, 201 Dowman Drive, Atlanta, GA, 30322, USA 9 MAEBIOS, 1610 Juniper Drive, Alamogordo, NM, 88310 USA

* Corresponding author: [email protected]

mailto:[email protected]

Table S1: FOXP2 coding exon coordinates in GRCh37/ hg19 as used for numbering in this study

Full exon Translated region of exon

Exon nr Ensembl nr Start End Length

(bp) Start End Length

(bp) Exon 2 ENSE00003592860 114426502 114426679 178 114066567 114066734 167 Exon 3 ENSE00003598938 114534617 114534706 90 114174672 114174761 89 Exon 4 ENSE00003561477 114628540 114628677 138 114268595 114268732 137 Exon 5 ENSE00003784625 114629856 114630005 150 114269911 114270060 149 Exon 6 ENSE00003689434 114631528 114631705 178 114271583 114271760 177 Exon 7 ENSE00003599193 114642410 114642623 214 114282465 114282678 213 Exon 8 ENSE00003569605 114644685 114644789 105 114284740 114284844 104 Exon 9 ENSE00003491906 114652203 114652290 88 114292258 114292345 87 Exon 10 ENSE00003652522 114653926 114654009 84 114293981 114294064 83 Exon 11 ENSE00003572969 114658066 114658267 202 114298121 114298322 201 Exon 12 ENSE00003585047 114659356 114659432 77 114299411 114299487 76 Exon 13 ENSE00003606163 114659572 114659673 102 114299627 114299728 101 Exon 14 ENSE00003527883 114662065 114662186 122 114302120 114302241 121 Exon 15 ENSE00003543277 114663450 114663519 70 114303505 114303574 69 Exon 16 ENSE00003498832 114664273 114664436 164 114304328 114304491 163 Exon 17 ENSE00003785442 114689782 114691745 1964 114329837 114329981 144

Table S2: primer sequences and PCR conditions for amplification of FOXP2 exons 4 – 17 using Sanger sequencing

Exon Primer sequence (5’ - 3’) Amplicon (bp) TM Mg++

Primer concentration

(nM)

PCR cycles

Exon 4 fwd acagatatttggttatgaccacg 242 56 1.5 mM 16 pmol 32 Exon 4 rev gcacaccttctaagtcatgctag Exon 5-6 fwd tttggctctgaccctttagaa 541 56 1.5 mM 16 pmol 32 Exon 5-6 rev atctaagactattcttgccgctc Exon 7 fwd caggcaatgaaaggagtgtgc 339 56 1.5 mM 16 pmol 32 Exon 7 rev agaaaggccatgaaatggtag Exon 8 fwd ctttaccttgttatgctagtg 335 56 1.5 mM 16 pmol 31 Exon 8 rev attgttctttttcattgtctc Exon 9 fwd tgctctgagctgaattgacc 330 52 1.5 mM 16 pmol 31 Exon 9 rev gacttttacattcctccttcatc Exon 10 fwd gtagtgctttttaagtgtagcc 230 56 1.5 mM 16 pmol 32 Exon 10 rev tcagtactcaatgtaacacacc Exon 11 fwd ggcaagctcaatgataagatgtatc 288 54 1.5 mM 16 pmol 32 Exon 11 rev tattgccgtatttttcatcacactc Exon 12 fwd gaatccactctcatttgtcaaacc 371 56 1.5 mM 16 pmol 32 Exon 12 rev ctctggaatggctcatgtacag Exon 13-14 fwd agaaattgccccaaactatga 367 56 1.5 mM 16 pmol 32 Exon 13-14 rev ctgtaaggaactgtggtagg Exon 15 fwd tagtatgttgggctgccttattag 230 54 1.5 mM 16 pmol 32 Exon 15 rev gatgcaggatacaggattacaaaac Exon 16fwd ctattagtgtgagacaagccag 218 56 1.5 mM 16 pmol 32 Exon 16 rev gccctaaacattcaaatacaac Exon 17 fwd ggaacccattaaaagaagatac 286 54 1.5 mM 16 pmol 32 Exon 17 rev attcttccctttagagagtctg Exon 18 fwd tcttcactgcaaagttggcc 395 54 1.5 mM 16 pmol 32 Exon 18 rev ttgcctgttggtactgaatcc TM = Annealing temperature, Mg++ = Magnesium concentration

Table S3: primer sequences and PCR conditions for amplification of poly Q microsatellites

Microsatellite Primer sequence (5’ - 3’) Annealing Temperature (°C)

Primer concentration (nM)**

PCR cycles

Q1 exon 5 fwd* AGA GCA GTT ACA TCT TCA GC 49 10 351 Q1 exon 5 rev ACC TCT TTC GCT TGC TTT C Q2 exon 6 fwd* CTG CTG TTT ACT GGT TTG GGT TTT C 49 10 302 Q2 exon 6 rev CTG GAA GAC AAG CTG CTG GG

*Forward primers were fluorescently labelled (Q1: 6-FAM; Q2: HEX). **12.5 µL PCR reaction mix contained 6.25 µL QIA hotstar master mix (Qiagen), 0.5 µL of each primer, 3.25 µL of water and approximately 40ng of genomic DNA. 1 Initial incubation at 95°C (10 minutes), followed by 35 cycles at 95°C (30 s), 49°C (40 s), 72°C (40 s) and a final extension period of 10 minutes at 72°C. 2 PCR reaction mix and cycle conditions identical to poly Q1 except for number of cycles and the final extension period, which were set to 30 cycles and 30 minutes respectively.

Table S4: List of genome names and species included in dN/dS selection modelling

GENOME IS GENUS SPECIES COMMON NAME

AILMEL1 Ailuropoda melanoleuca Giant panda BOSTAU7 Bos taurus Cow CALJAC3 Callithrix jacchus Common marmoset CAMFER1 Camelus ferus Wild Bactrian camel CANFAM3 Canis familiaris Domestic dog CAPHIR1 Capra hircus Goat CAVPOR3 Cavia porcellus Guinea pig CERSIM1 Ceratotherium simum White rhinoceros CHILAN1 Chinchilla lanigera Long-tailed chinchilla CHLSAB1 Chlorocebus sabeus Green monkey CHRASI1 Chrysochloris asiatica Cape golden mole CONCRI1 Condylura cristata Star-nosed mole DASNOV3 Dasypus novemcinctus Nine banded armadillo ECHTEL2 Echinops telfairi Lesser hedgehog tenrec ELEEDW1 Elephantulus edwardii Elephant shrew EPTFUS1 Eptesicus fuscus Big brown bat EQUCAB2 Equus caballus Horse ERIEUR2 Erinaceus europaeus European hedgehog FELCAT5 Felis catus Domestic cat GORGOR3 Gorilla gorilla Gorilla HETGLA2 Heterocephalus glaber Naked mole rat JACJAC1 Jaculus jaculus Lesser Egyptian jerboa LEPWED1 Leptonychotes weddellii Weddell seal LOXAFR3 Loxodonta africana African elephant MACFAS5 Macaca fascicularis Crab-eating macaque MESAUR1 Mesocricetus auratus golden hamster MICOCH1 Microtus ochrogaster Prairie vole MM10 Mus musculus House mouse MUSFUR1 Mustela putorius Ferret MYODAV1 Myotis davidii David's bat MYOLUC2 Myotis lucifugus Little brown bat NOMLEU3 Nomascus leucogenys Northern white-cheeked gibbon OCHPRI3 Ochotona princeps Pika OCTDEG1 Octodon degus Common degu ODOROSDIV1 Odobenus rosmarus Pacific walrus HG19 Homo sapiens Human ORCORC1 Orcinus orca Orca whale

ORYAFE1 Orycteropus afer Aardvark ORYCUN2 Oryctolagus cuniculus European rabbit OTOGAR3 Otolemur garnettii Northern greater galago OVIARI3 Ovis aries Sheep PANHOD1 Pantholops hodgsonii Tibetan antelope PANTRO4 Pan troglodyetes Chimpanzee PAPHAM1 Papio hamadryas Hamadryas baboon PONABE2 Pongo abelii Sumatran orangutan PTEALE1 Pteropus alecto Black flying fox PTEVAM1 Pteropus vampyrus Large flying fox RHEMAC3 Macaca mulatta Rhesus macaque RN5 Rattus norvegicus Norway rat SAIBOL1 Saimiri boliviensis Black-capped squirrel monkey SORARA2 Sorex araneus European shrew SPETRI2 Spermophilus tridecemlineatus Thirteen-lined ground squirrel SUSSCR3 Sus scofa Pig TRIMAN1 Trichechus manatus West Indian manatee TUPCHI1 Tupaia chinensis Chinese treeshrew TURTRU2 Tursiops truncatus Common bottlenose dolphin VICPAC2 Vicuna pacos Alpaca

Supplementary Methods 1: Details on software and methodology used for dN/dS analysis

We downloaded the multiZ 100-way vertebrate alignment for the canonical transcript of FOXP2 from the

UCSC Genome Browser 1. We analyzed the alignment using the Ete Toolkit (version 3.0.0b36), a python-

based phylogenetic analysis package 2. Within the Ete Toolkit, RAxML (version 8.1.20)3 was first used to

infer the gene tree from the alignment. Next, sitewise dN/dS was estimated and evidence for selection

tested for within a maximum likelihood framework using the Sitewise Likelihood Ratio (SLR) method 4 and

codeml site models 5. SLR performs a likelihood ratio test (LRT) at each site in a protein to detect, after

correcting for multiple tests, significant deviations from neutrality (purifying or positive selection) at a

site. In codeml, a null model (M0) of a single dN/dS across sites is compared via LRT with a model of two

classes of dN/dS (M1; purifying and neutral) and three classes of dN/dS (M2; purifying, neutral, and

positive).

References used:

1. Kent, W. et al. The human genome browser at UCSC. Genome Res. 12, 996–1006 (2002).

2. Huerta-Cepas, J., Serra, F. & Bork, P. ETE 3: reconstruction, analysis, and visualization of phylogenomic data. Mol. Biol. Evol. 33, 1635–1638 (2016).

3. Stamatakis, A. RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. Bioinformatics 30, 1312–1313 (2014).

4. Massingham, T. & Goldman, N. Detecting amino acid sites under positive selection and purifying selection. Genetics 169, 1753–1762 (2005).

5. Yang, Z., Nielsen, R., Goldman, N. & Pedersen, A. Codon-substitution models for heterogeneous selection pressure at amino acid sites. Genetics 155, 431–449 (2000).

Table S5: Single nucleotide variations for FOXP2 coding sequences across hominoids. Coding variants are bolded and underlined. Single nucleotide polymorphisms are indicated following IUPAC ambiguity codes. Grey shading indicates variants located inside the variable poly Q stretches.

DNA base location in human coding sequence 17 136 180 249 258 270 354 381 390 414 441 459 462

human C A A A G A A T G G G A A

Chimpanzee C W G R G A C T G G G A A

Bonobo C A A A R A C T G G R A A

Gorilla C A A A G G C T K R G R R

Orangutan T A A A G A C C G G G R A

Gibbon C A A A G A C C G G G G A


human A A A A G G G G G G A A G

Chimpanzee A R R A G G G G G G A A G

Bonobo A A R A G G G G G G A A G

Gorilla R A R A G G G G G G A A G

Orangutan A A A R R R R R R G R A G

Gibbon A A A A G G G G G A G G A


human C A A A A G G A A C A T G

Chimpanzee C A C G C A G M A C R T G

Bonobo M A C G C A G A A C A T G

Gorilla C A C A A A K A R C A T A

Orangutan C C C A A A G A A Y A Y G

Gibbon C A C A A A G A A C A T G

DNA base location in human coding sequence

1563

1803 1831 1842 1878 1908 1932 1941 1968 1992 2016 2046

human A A C A C T G A C A C A

Chimpanzee A A C A Y C G A C A M A

Bonobo A A C A C C G A C A C A

Gorilla A R C A C T G A T A C G

Orangutan G A M C C T G R T A C A

Gibbon A A C C C T A G T G C A

Figure S1: Structure prediction of FOXP2 N- and C-terminal regions. A. Sequence alignment of the wild-type and Ala326Ser mutant FOXP2-APQ region using three different algorithms. B. QUARK predicted structure of the FOXP2-APQ region. Structures of three wild-type and three mutant structures are superimposed. The central helix of one structure is shown while helix 2 and 3 for both wild-type (green) and mutant (magenta) structures are shown to indicate variations within each set of structures. Similarly, the variations in locations of Ala326 (green) and Ser326 (magenta) are shown in spheres. In addition, a surface representation of the structure depicting basic (blue) and acidic (red) residue distribution is depicted. C. Amino acid sequence of adjacent residues to the site of mutation showing potential kinase recognition motifs introduced by the Ser326 mutation.

0 5 10 15 20 25 30 35 40 45 50 55 60 65 70 75 80 85 90 95 100 105 110 115 120 125 130 135 140 145 150 155 160 165 170 175 180 185 190 195 200 205 210 215 220 225 230 235 240 245 250 255 260 265 270 275 280 285 290 295 300 305 310 315 320 325 330 335 340 345 350 355 360 365 370 375 380 385 390 395 400 405 410 415 420 425 430 435 440 445 450 455 460 465 470 475 480 485 490 495 500 505 510 515 520 525 530 535 540 545 550 555 560 565 570 575 580 585 590 595 600 605 610 615 620 625 630 635 640 645 650 655 660 665 670 675 680 685 690 695 700 705 710 715 720 725 730 735 739

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Omega(ω)

OmegavalueforsitesunderM1model

0 5 10 15 20 25 30 35 40 45 50 55 60 65 70 75 80 85 90 95 100 105 110 115 120 125 130 135 140 145 150 155 160 165 170 175 180 185 190 195 200 205 210 215 220 225 230 235 240 245 250 255 260 265 270 275 280 285 290 295 300 305 310 315 320 325 330 335 340 345 350 355 360 365 370 375 380 385 390 395 400 405 410 415 420 425 430 435 440 445 450 455 460 465 470 475 480 485 490 495 500 505 510 515 520 525 530 535 540 545 550 555 560 565 570 575 580 585 590 595 600 605 610 615 620 625 630 635 640 645 650 655 660 665 670 675 680 685 690 695 700 705 710 715 720 725 730 735 739

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OmegavalueforsitesunderSLRmodel

Spermophilus_tridecemlineatus M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q E L L P E T K L C V C G H S S G D G H P H N T F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q - Q H P G K Q A K E H Q Q Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N S S S S T T S S T T S K A S P P V T H H S I V N G Q S - - - - - - - - X S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H I D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Rattus_norvegicus M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q E L L P E A K L C V C G H S P G D G H P Y S T F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q - - - - Q H P G K Q A K E Q Q Q Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q C Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S Q E D N G I K H G G L D L T T N N S S S T T S S T T S K A S P P I T H H S I V N G Q S S V L N A R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H I D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Mus_musculus M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S E K Q R P L Q E L L L E A K L C V C V H S P G D G H P H S T F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q X X Q H P G K Q A K E Q Q Q Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N N S S S T T S S T T S K A S P P I T H H S I V N G Q S S V L N A R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H I D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Mesocricetus_auratus M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T A E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q S L L P E T K V Y V F G H S P G D R Y S Q S T F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q X Q Q Q Q Q Q Q Q - - - - Q H P G K Q A K E Q Q Q Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N N S S S T T S S N S S K A S P P I T H H S I V N G Q S S V L N A R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H I D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Microtus_ochrogaster M M Q E S A T E T I S N S S M N Q N G M S T L G S Q L D A G S R D G R P S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q E L L P E T K L C V C G H S P D D S Y P H N P F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q X Q Q Q Q Q Q Q Q - - - - Q H P G K Q A K E Q Q Q Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H T M E D N G I K H G G L D L T T N N S S S T T S S T T S K A S P P I T H H S I V N G Q S S V L N A R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H I D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Jaculus_jaculus M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D A S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S E K Q R P L Q E L F P E A K L C V C G H S S G D G H P H N S F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q P P H P G K Q A K E Q Q Q Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N N S S S T T S S T T S K A S P P I T H H S I V N G Q S S V L N A R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H I D S N G N N S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Eptesicus_fuscus M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q Q L F P E X K L C V C G H S S S D G H P H S T S A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q X - - - X Q Q Q Q Q Q Q Q Q H P G K Q V K E - - - Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N N S S L T T S P T T S K A S P P I T H H S I V N G Q S S V L N T R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H M D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P V S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Myotis_davidii M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q Q L F P E X K L C A C G H S S G D G H P H S T S A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q X - - - X Q Q Q Q Q Q Q Q Q H P G K Q V K E - - - Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N N S S L T T S P T T S K A S P P I T H H S I V N G Q S S V L N T R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H M D S N G N S S P G C S P Q P H I H S I H V K E E P V M A E D E D C P V S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Myotis_lucifugus M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q Q L F P E X K L C A C G H S S G D G H Q H S M S A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q X - - - X Q Q Q Q Q Q Q Q Q H P G K Q V K E - - - Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N N S S L T T S P T T S K A S P P I T H H S M V N G Q S S V L N T R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H M D S N G N S S P G C S P Q P H I H S I H V K E E P V M A E D E D C P V S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Pteropus_vampyrus M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - E L L P E T K L C I C G H S S G D G H P H N T F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q X - - - X Q Q Q Q Q Q X - X H P G K Q A K E - - - Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V A G V H S M E D N G I K H G G L D L T T N N S S S T T S S T T S K V S P P I T H H S I V N G Q S S L L N A R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H I D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Pteropus_alecto M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q E L L P E T K L C I C G H S S G D G H P H N T F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q X - - - X Q Q Q Q Q Q X - X H P G K Q A K E - - - Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N N S S S T T S S T T S K V S P P I T H H S I V N G Q S S L L N A R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H I D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Felis_catus M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q E L L P E T K L C V C G H S S G D G H P H N T F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q X - - - - - X Q Q Q P P P P P H P G K Q A K E - Q Q Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N N S S S T T S S T T S K A S P P I T H H S I V N G Q S S V L S A R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H I D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Canis_familiaris M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q E L L P E T K L C V C G H S S G D G H P H N T F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q X - - - X Q P Q Q P P P P P H P G K Q A K E - - - Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N N S S S T T S S T T S K A S P P I T H H S I V N G Q S S V L S A R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H I D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Ailuropoda_melanoleuca M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q E L L P E T K L C V C G H S S G D G H P H N T F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X - - - - - - - - - - - - - - - - - - X Q Q Q Q Q Q Q X - - - - X P Q Q P P P P P H P G K Q A K E - - - Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N N S S S T T S S T T S K A S P P I T H H S I V N G Q S S V L S A R R D S S S H E D T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H I D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Mustela_putorius_furo M M Q E S A T E T I S N S S M N Q N G M S A L S S Q L D A G S R D G R S S G D T S S D V S P V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q E L L P E T K L C V C G H S S G D G H P H N T F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L H Q Q Q A V M L Q Q - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - X Q P Q Q P P P P P H P G K Q A K E - - - Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N N S S S T T S S T T S K A S P P I T H H S I V N G Q S S V - - - - - - X S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H I D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Odobenus_rosmarus_divergens M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q E L L P E T K L C V C G H S S G D G H P H N T F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q X - - - - X P Q Q P P P P P H A G K Q A K E - - - Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N N S S S T T S S T T S K A S P P I T H H S I V N G Q S S V L S A R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H I D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Leptonychotes_weddellii M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q E L L P E T K L C V C G H S S G D G H P H N T F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L L Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q X - - - - X P Q Q P P P P P H A G K Q A K E - - - Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N N S S S T T S S T T S K A S P P I T H H S I V N G Q S S V L S A R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H I D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Vicuna_pacos M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q E L L P E T K L C V C G H S S G D G H P H N T F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q P X - - X Q Q P P P - - P P P H P G K Q A K E - - Q Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N N S S S T T S S T T S K A S P P I T H H S I V N G Q S S V L N A R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H M D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Camelus_ferus M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q E L L P E T K L C V C G H S S G D G H P H N T F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q P X - - X Q P P P P - - P P P H P G K Q A K E - - Q Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N N S S S T T S S T T S K A S P P I T H H S I V N G Q P S V L N A R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H M D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Sus_scofa - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q E L L P E T K L C V C G H S S G D G H P H N T F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q X - - X Q Q Q Q Q Q Q Q Q Q H P G K Q A K E - - Q Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M D D N G I K H G G L D L T T N N S S S T T S S T T S K A S P P I T H H S I V N G Q S S V L N A R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H L D S N G N S S P G C S P Q P H I H S I H V K E E P V M A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Bos_taurus M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q E L L P E T K L C V C G H S S G D G H P H N T F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q X - - X Q Q Q Q Q Q P Q Q Q H P G K Q A K E - - - - Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N N S S S T T S S T T S K A S P P I T H H T I V N G Q S S V L N A R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H I D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Pantholops_hodgsonii M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q E L L P E T K L C V C G H S S G D G H P H N T F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q X - - X Q Q Q Q Q Q P Q Q Q H P G K Q A K E - - - - Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N N S S S T T S S T T S K A S P P I T H H T I V N G Q S S V L N A R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H I D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Ovis_aries M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q E L L P E T K L C V C G H S S G D G H P H N T F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q X - - X Q Q Q Q Q Q P Q Q Q H P G K Q A K E - - - - Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N N S S S T T S S T T S K A S P P I T H H T I V N G Q S S V L N A R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H I D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Capra_hircus M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q E L L P E T K L C V C G H S S G D G H P H N T F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q X - - X Q Q Q Q Q Q P Q Q Q H P G K Q A K E - - - - Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N N S S S T T S S T T S K A S P P I T H H T I V N G Q S S V L N A R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H I D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Orcinus_orca M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q E L L P E T K L C V C G H S S G D G H P H N T F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q X - - X Q Q Q Q Q Q - Q Q Q H P G K Q A K E - - - Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N N S S S T T S P T A S K A S P P I T H H S M V N G Q S S V L N A R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N T S S G L L Q A V H E D L N G S L D H I D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Tursiops_truncatus M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q E L L P E T K L C V C G H S S G D G H P H N T F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q X - - X Q Q Q Q Q Q - Q Q Q H P G K Q A K E - - - Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N N S S S T T S P T A S K A S P P I T H H S M V N G Q S S V L N A R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N T S S G L L Q A V H E D L N G S L D H I D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Sorex_araneus M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q E L L P E T K L C V C G H S S G D G H P H N T F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q X - - X Q Q Q P P P P P P Q H P G K Q A K E - - - Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S L P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N A I K H G G L D L T T N N S S S T T S S T T S K A S P P I T H H S I V N G Q S S V L N A R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H I D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Erinaceus_europaeus M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K N S E K Q R P L Q E L L P E T K L C V C G H S S G D G H P H N T F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q X - - X Q Q - - - - - - Q Q H P G K Q A K E Q Q Q Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A T L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G V K H G G L D L T T N N S S S T T S S T T S K A S P P I T H H S I V N G Q S S V L N S R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H I D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Ceratotherium_simum M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q E L L P E T K L C I C G H S S G D G H P H N T F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L L Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q X - - - X Q Q Q Q Q Q Q Q - H P G K Q A K E - - - Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N N S S S T T S S T A S K A S P P I T H H S I V N G Q S S V L N A R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H I D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Equus_caballus M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S G D K Q R P L Q E L L P E T K L C V C G H S S G D G H P H N T F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q X - - - X Q Q Q Q Q Q Q Q Q H P G K Q A K E - - Q Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N N S S S T T S S T T S K A S P P I T H H S I V N G Q S S V L N A R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H I D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Echinops_telfairi M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T G G L K S P K S S E K Q R P L Q E L L P E T K L C V C G L S S G D G H P H N P F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q H P G K Q A K E X Q Q Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V A G V H S V E D S G S K H G G L D L T T N N S S S T T S S T T S K A S P P I T H H S I V N G Q S S V L N A R R D S S S H E E P G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H M H S N G N S S P G G S P Q P H I H S I H V K E E P G I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Chrysochloris_asiatica M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q E L L P E T K L C A S G L S C G D G H P D N T L A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q H P G K Q V K E P Q Q Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q I Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N N S S S T T S S T T S K A S P P I S H H S I V N G Q S S V L N A R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H I D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E E D R E I E E E P L S E D L E

Orycteropus_afer_afer M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D S S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q A L L P E T K L S V C G L S S G D G Y P H N T F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q P Q Q Q Q Q P Q Q Q P P P P P Q P P Q H Q Q Q H P G K Q A K E - - H Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N N S S S T T S S T T S K A S P P I T H H S I V N G Q A S V L N A R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A A H E D L N G C L E H V D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P D L E D D R E I E E E P L S E D L E

Trichechus_manatus_latirostris M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q E L L P E T K L C V C G L S S G D G H L Y N I F T V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q H P G K Q A K E - P H H Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N N S S S T T S S T T S K A S P P I T H H S I V N G Q S S V L N A R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H I D S N G N S S P G C S P Q P H L H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L D D D R E I E E E P L S E D L E

Loxodonta_africana M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q E L L P E T K L C V C G F S S G N G H P Y N T L T V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q - - Q Q Q Q Q Q Q Q Q Q Q - Q Q Q Q Q Q H P G K Q A K E H H Q Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N N S S S T T S S T T S K A S P P I T H H S I V N G Q S S V L N A R R D S S S H E E T G A C H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H I D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Elephantulus_edwardii M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S G D K Q R P L Q E L L P E T K L C V C G L S S G D G H P H N T L A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q - - Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q H P G K Q A K E - H Q Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N N S S S T T S S T T S K A S P P I T H H S I V N G Q S S V L N A R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H I D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Ochotona_princeps M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S A E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q E L L P E T K L C V C G H S S G D G H P H N P F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q P P P - - Q P P P Q Q P P X - - - - - X Q P P Q Q P Q P P Q Q P Q H P G K Q A K E Q Q Q Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N N S S S T T S S T T S K A S P P I T H H S I V N G Q S S V L N A R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P I T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H M D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Oryctolagus_cuniculus M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q E L L P E T K L C V C G H S S G D G H P H N T F A V P V S V A M M T P Q V M T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q X - - - - - X Q Q Q Q Q Q Q Q Q Q Q Q Q H P G K Q A K E Q Q Q Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N N S S S T T S S T T S K A S P P I T H H S I V N G Q S S V L N A R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H I D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Tupaia_chinensis M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q E L L P E T K L C V C G H S S G D G Q P H N T F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q T Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q H P G K Q A K E Q Q Q Q Q - - - - Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N N S S S T T S S T T S K A S P P I T H H S I V N G Q S S V L N A R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H I D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Otolemur_garnettii M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - E L L P E T K L C V C G H S S G D G H P H N T F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q H P G K Q A K E Q Q Q Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N N S S S T T S S T T S K A S P P I T H H S I V N G Q S S V L N A R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P S V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S G G L L Q A V H E D L N G S L D H I D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Callithrix_jacchus M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q E L L P E T K L C I C G H S S G D G H P H N T F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q - Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q H P G K Q A K E Q Q Q Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N N S S S T T S S T T S K A S P P I T H H S I V N G Q S S V L N A R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H M D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Saimiri_boliviensis M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q E L L P E T K L C I C G H S S G D G H P H N T F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q H P G K Q A K E Q Q Q Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N N S S S T T S S T T S K A S P P I T H H S I V N G Q S S V L N A R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H I D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Chlorocebus_sabeus M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q E L L P E T K L C I C G H S S G D G H P H N T F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q H P G K Q A K E Q Q Q Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N N S S S T T S S T T S K A S P P I T H H S I V N G Q S S V L N A R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H I D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E E D R E I E E E P L S E D L E

Papio_hamadryas M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q E L L P E T K L C I C G H S S G D G H P H N T F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q H P G K Q A K E Q Q Q Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N N S S S T T S S T T S K A S P P I T H H S I V N G Q S S V L N A R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H I D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Macaca_mulatta M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q E L L P E T K L C I C G H S S G D G H P H N T F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X - - - - - - - - - - - - - - - - - - - - - - - - - - - - X Q Q Q Q Q Q Q Q Q Q Q H P G K Q A K E Q Q Q Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N N S S S T T S S T T S K A S P P I T H H S I V N G Q S S V L N A R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H I D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Macaca_fascicularis M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q E L L P E T K L C I C G H S S G D G H P H N T F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q H P G K Q A K E Q Q Q Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N N S S S T T S S T T S K A S P P I T H H S I V N G Q S S V L N A R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H I D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Pongo_abelii M M Q E S V T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q E L L P E T K L C I C G H S S G D G H P H N T F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q H P G K Q A K E Q Q Q Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N N S S S T T S S T T S K A S P P I T H H S I V N G Q S S V L N A R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P H F S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H I D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Gorilla_gorilla M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q E L L P E T K L C I C G H S S G D G H P H N T F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X - - - - - - - - - - - - - - - - - - - - - - - - - - - - X Q Q Q Q Q Q Q Q Q Q Q H P G K Q A K E Q Q Q Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q X - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - X S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H I D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Homo_sapiens M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q E L L P E T K L C I C G H S S G D G H P H N T F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L L Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q H P G K Q A K E Q Q Q Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N N S S S T T S S N T S K A S P P I T H H S I V N G Q S S V L S A R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H I D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Pan_troglodyetes M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q E L L P E T K L C I C G H S S G D G H P H N T F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L L Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q H P G K Q A K E Q Q Q Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N N S S S T T S S T T S K A S P P I T H H S I V N G Q S S V L N A R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H I D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Nomascus_leucogenys M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q E L L P E T K L C I C G H S S G D G H P H N T F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q H P G K Q A K E Q Q Q Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N N S S S T T S S T T S K A S P P I T H H S I V N G Q S S V L N A R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H I D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Condylura_cristata M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q E L L P E T K L C V C G H S S G D G H P H N T F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q X - - X Q Q Q Q Q Q Q - Q Q H P G K Q A K E Q Q Q Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N N S S S T T S S T T S K A S P P I T H H S I V N G Q S S V L N A R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H I D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Dasypus_novemcinctus M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q E L L P E T K L C V C G L S S G D G H P H N T F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q - Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q H P G K Q A K E - - - H Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N N S S S T T S S T T S K A S P P I T H H S I V N G Q S S V L N A R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - X H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Heterocephalus_glaber M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q E L L P E T K L C V C G H S S G D G L P H N T F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q H P G K Q A K E Q Q Q Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q A A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N N S S S T T S S S T S K A S P P I T H H S I M N G Q S S V L N A R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H I D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Cavia_porcellus M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R P S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q E L L P E T K L C V C G H S S G D G L P H N S F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q H P G K Q A K E Q Q - Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L S L Q R Q G L I S I P P G Q P A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T N N S S S T T S S T T S K A S P P I T H H S I V N G Q S S V L N A R R D S S S H E E T G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H I D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Octodon_degus M M Q E S A T E T I S N S S M N Q N G M S T L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S G D K H R P L Q E L L P E T K L C V C G H S S G D G A P H N T F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q P Q Q Q P Q Q Q Q Q P P P P P P H P G K Q A K E Q Q Q Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L L Q M Q Q L Q Q Q Q H L L N L Q R Q G L I S I P P G Q P A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S V E D N G M K H G G L D L T T N S S S S T T S S T T S K A S P P I T H H S L V N G Q S S V L N A R R D S S S H E E A G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N A S S G L L Q A V H E D L N G S L D H I D S N G N S S P G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

Chinchilla_lanigera M M Q E S A T E T I S N N S M N Q N G M S A L S S Q L D A G S R D G R S S G D T S S E V S T V E L L H L Q Q Q Q A L Q A A R Q L L L Q Q Q T S G L K S P K S S D K Q R P L Q E L L P E T K L C V C G H S S A D G L P H N T F A V P V S V A M M T P Q V I T P Q Q M Q Q I L Q Q Q V L S P Q Q L Q A L L Q Q Q Q A V M L Q Q Q Q L Q E F Y K K Q Q E Q L H L Q L X X Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q H A G K Q A K E Q Q Q Q Q Q Q Q Q Q L A A Q Q L V F Q Q Q L I Q M Q Q L Q Q Q Q H L L N L Q R Q G L I S I P P G Q P A L P V Q S L P Q A G L S P A E I Q Q L W K E V T G V H S M E D N G I K H G G L D L T T X X S S S T T S S T A S K A S P P I T H H S I V N G Q S S V L N A R R D S S S H E E P G A S H T L Y G H G V C K W P G C E S I C E D F G Q F L K H L N N E H A L D D R S T A Q C R V Q M Q V V Q Q L E I Q L S K E R E R L Q A M M T H L H M R P S E P K P S P K P L N L V S S V T M S K N M L E T S P Q S L P Q T P T T P T A P V T P I T Q G P S V I T P A S V P N V G A I R R R H S D K Y N I P M S S E I A P N Y E F Y K N A D V R P P F T Y A T L I R Q A I M E S S D R Q L T L N E I Y S W F T R T F A Y F R R N A A T W K N A V R H N L S L H K C F V R V E N V K G A V W T V D E V E Y Q K R R S Q K I T G S P T L V K N I P T S L G Y G A A L N A S L Q A A L A E S S L P L L S N P G L I N N S S S G L L Q A V H E D L N G S L D H I D S N G N S S A G C S P Q P H I H S I H V K E E P V I A E D E D C P M S L V T T A N H S P E L E D D R E I E E E P L S E D L E

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foxp2 variation in great ape populations offers insight ... › esm › art:10.1038... ·...

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