funded by us national institute on aging grants r01-ag10569 and t32-ag00037
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Long Beach Longitudinal Study Elizabeth Zelinski, PhD Rita and Edward Polusky Chair in Aging and Education USC Davis School of Gerontology. Funded by US National Institute on Aging Grants R01-AG10569 and T32-AG00037. Acknowledgements. - PowerPoint PPT PresentationTRANSCRIPT
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Long Beach Longitudinal Study
Elizabeth Zelinski, PhDRita and Edward Polusky Chair in Aging
and EducationUSC Davis School of Gerontology
Funded by US National Institute on Aging Grants R01-AG10569 and T32-AG00037
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Friday Harbor Psychometrics Workshop 2010
Acknowledgements
• Funded in part by Grant R13AG030995-01A1 from the National Institute on Aging
• The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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Collaborators• Kristin Antonio• Josette Bowers• Megan Braziel• Lisa Breen• Kerry Burnight, PhD• Sarah Canetti• Grace Sit Chan• Kami Chin• Althea De Pietro• Robin Engberg• Elena Estrada• Michael Gilewski, PhD• Amber Hall, PhD• Shoshana Hindin• George Holman• Patricia Housen, PhD
• Robert Kennison, PhD• Deanah Kim• Shirley Kirksey• Christianne Lane• Kayan Lewis, PhD• Jack McArdle, PhD• Kevin Petway• Joyce Riley• Mariette Salama• K. Warner Schaie, PhD• Aisha Shaheen• Marc Simpao, MD• Susan Stewart, PhD• Erin Westphal
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Purposes of the Long Beach Longitudinal Study
• to document cognitive change in healthy older adults
• to identify mechanisms of change with individual differences models
• extend models of change to a relatively large sample of the oldest-old: 50% of sample is currently over age 80
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Age
HealthContext
SocialContext
Cognition
Model Effects of aging on the social and health-related environment. These affect cognition in older adults, though cognitive status may affect some aspects of health and social functioning.
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Data• Each panel retested every 3-5 years• Goal--development of growth models of cognitive change and its correlates throughout adulthood
• Measures are of• STAMAT:
– INDUCTIVE REASONING: letter series & word series– SPACE: figure rotation & object rotation– Word fluency (EXECUTIVE)– VOCABULARY (STAMAT & 2 ETS advanced vocabulary)
LIST RECALL: 2 lists TEXT RECALL: 3 short passagesWORKING MEMORY: 3 measuresSPEED: pattern, number, letter comparisonRARE WORD DEFINITIONDisourse production
• Lifestyle: Life Complexity Inventory: Social networks, neighborhood, educational & cultural activities, exercise • Personality: NEO-PI-R (5 factors)• Memory Functioning Questionnaire: Frequency of Forgetting• Health: Seattle Health Behaviors (+ specific medical conditions)
• IN PROCESS (oldest participants):• Blood samples for DNA/RNA analysis; blood lipids, markers for vascular & inflammatory risk• Imaging: Brain: brain volume & specific structures, WMH, cortical thickness; • Carotid intima media thickness, • Retinal photography
• All participants:• HRS physical function measures (BP, BMI, tandem walk, gait speed), lung capacity, grip strength• HRS cognitive measures
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2007-10
22-year birth cohort difference from Panel 1
6-year birth cohort difference from Panel 2
1978 1981 1994-95 1997-98 2000-02 2003-05
Panel 1/Cohort 1N = 583
Panel 1/Cohort 1N = 264
Panel 1/Cohort 1N = 106
Panel 1/Cohort 1
N = 42
Panel 1/Cohort 1
N = 15
Panel 2/Cohort 2N = 630
Panel 2/Cohort 2N = 352
Panel 2/Cohort 2N = 173
Panel 2/Cohort 2N = 133
Panel 3/Cohort 3N = 911
Panel 3/Cohort 3N = 513
16 year birth cohort difference from Panel 1
Panel 1/Cohort 1
N = 20
Panel 2/Cohort 2N = 102
Panel 3/Cohort 3N = 296
Panel 1/Cohort 1
N = 0
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IQ Subtests, Cohort, and Change (Zelinski & Kennison,
2007)• Compared age changes in people 55-82• Compared 2 16-year birth cohorts• Average birth years
– Cohort 1: 1906 (1897-1923)– Cohort 2: 1922 (1912-1939)
• Recalibration of test scores into the same interval metric via Rasch scaling to compare relative age and cohort differences
• Hypothesis: cohort differences in more fluid abilities; no differences in more crystallized
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Zelinski & Kennison, 2007
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20
30
40
50
60
70
80
56 59 62 65 68 71 74 77 80 83 86
Age
C1 Vocabulary
C2 Vocabulary
C1 Space
C2 Space
C1 List
C2 List
C1 Text
C2 Text
C1 Reasoning
C2 Reasoning
Longitudinal Age Effects by Cohort
Growth model over age; Intercept age 72
More recently born cohort better performance at intercept for more fluid like abilities
Larger cohort differences for reasoning & recall; but age declines on average
Zelinski & Kennison, 2007
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Do accelerations of age slopes vary by cohort?
• Data in Zelinski & Kennison modeled at the average age of the sample
• Measures differed at the intercept; do age declines accelerate at the same point across measures?– Do the cohorts have similar age breakpoints?– Are cohort differences observed at the average
intercept observed at the best-fitting age breakpoints for each of the measures ?
Kennison & Zelinski, in preparation
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Multiple Adaptive Regression Splines of Change Points over Age by Cohort
0
10
20
30
40
50
60
70
80
90
100
60 62 64 66 68 70 72 74 76 78 80 82 84 86
Age
Rasch score (0-100)
Reasoning cohort 1 Reasoning cohort 2
Space cohort 1 Space cohort 2
List cohort 1 List cohort 2
Text cohort 1 Text cohort 2
Vocabulary (both cohorts)
The advantage enjoyed by Cohort 2 at the first turning point is reduced or eliminated by very old age
• The initially greater cognitive reserve enjoyed by the later-born cohort may be more limited late in life due to age related declines or less selection at older ages compared to Cohort 1.
• The oldest Cohort 1 members may have had greater cognitive reserve due to selective survival (their Time 1 scores were higher than those of Cohort 2)
Kennison & Zelinski, in preparation
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Cohort differences in Activities as a predictor of change
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Mean/Proportiona (SD) Threshold SE Loadings SE
Factor Cohort/
Panel 1
Cohort/
Panel 2Invariant over Cohorts/Panels
Baseline N 399 521
Mental Fitness
Educational .28 (.45) .42 (.49) 0.94 .16 =1 0
Cultural .30 (.46) .41 (.49) 0.88 .13 0.89 3.96
Going out to Movies .12 (.32) .31 (.47) 1.28 .11 0.31 3.06
Self-Improvement .28 (.45) .39 (.49) 0.87 .10 0.62 4.44
Volunteering .32 (.47) .41 (.49) 0.62 .08 0.39 3.98
Writing/
Correspondence
.59 (.49) .68 (.47) -0.22 .07 0.30 3.20
Physical Fitness
Fitness .40 (.49) .60 (.49) 0.43 .11 =1 0
Participant Sports .28 (.45) .24(.43) 0.69 .08 0.31 2.99
Walking .67 (.47) .81 (.40) 0.47 .09 0.80 3.46
Outdoor Hobbies .38 (.49) .50 (.50) 0.35 .07 0.46 3.62
Means, Thresholds, and Factor Loadings of Mental And Physical Fitness Activities aMeans also represent the proportion of people reporting any participation in the activity because of categorical (0,1) coding.
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• Strict (strong) invariance of a categorical cognitive activity factor across 16-year cohorts and over 3 years (2 cohorts x 2 measurement occasions each)
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Longitudinal Self-Reported Activities by Cohort
Mental Physical
Zelinski, Lewis, Kennison & Watts, 2008
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“new” 1994+ measures
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.74
list
.74
text
.74
workingmemory
.77
speed
.95
vocab
3
.78 (1.0)
2
11 (.93)
6
.88 (1.0)
5
4 .94 (.92)
9
1.0 (1.0)
8
7.73 (.80)
12
1.0 (.86)
11
10 .88 (1.0 )
14
13 .94 (1.0)
.41
.52
.80
.61
.73
.63
.62
.47.43
.50
1.0 (.85)
Zelinski & Lewis, 2003
Multiple Group Factor Analysis Results (3 age x 2 occasions)
FactorSD
Factor Correlations
Spd WM Txt Lst
Full Information Data
Voc .92 .41 .70 .60 .46
Spd .76 .51 .45 .51
WM .67 .81 .64
Txt .70 .65
Lst .79
Retested Subjects Only
Voc .92 .42 .71 .60 .49
Spd .79 .46 .45 .51
WM .68 .80 .66
Txt .68 .66
Lst .78
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Age
Working Memory
Speed
Vocabulary
Text RecallList Recall
Age
Working Memory
Speed
Vocabulary
Text RecallList Recall
Models of List and Text recall as Related but Separate OutcomesReplication of model across two panels at Time 1
Replication of model within panels at Time 1 comparing retested subjects and Time 2 dropouts
Replication of model within 1994-95 panel over time 1 & time 2 comparing time 3 dropouts
Attrition did not markedly change results in the models, even over samples and over more than one retest.
This implies that relatively similar underlying patterns of cross-sectional interindividual differences in these measures across adulthood hold.
Lewis & Zelinski, 2010
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Findings
• No evidence of increased factor SDs or correlations– Over test occasions– Over retestee/dropout status– Between Panels 1 & 2 compared to Panel 3
• Conclusion: Structural relationships in LBLS remain invariant under a wide variety of cross sectional data samples– Measurement of resource constructs stable– No evidence for dedifferentiation
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ONE REASON WHY I HAVE HOPE FOR THE FUTURE OF LONGITUDINAL RESEARCH IN AGING
Older Adults desperate for WiFi, Death Valley Visitor Center, March 19, 2009