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Bi oMe d Central Page 1 of 12 (page number not for citation purposes) Journal of Hematology & Oncology Open Access Research Ganoderma lucidum polysaccharides can induce human monocytic leukemia cells into dendritic cells with immuno-stimulatory function Wing Keung Chan, Christopher Ching Hang Cheung, Helen Ka Wai Law, Yu Lung Lau and Godfrey Chi Fung Chan* Address: Department of Paediatrics & Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, PR China Email: Wing Keung Chan - [email protected]; Christopher Ching Hang Cheung - [email protected]; Helen Ka Wai Law - [email protected]; Yu Lung Lau - [email protected]; Godfrey Chi Fung Chan* - [email protected] * Corresponding author Abstract Background: Previous studies demonstrated Ganoderma lucidum polysaccharides (GL-PS), a form of bioactive β-glucan can stimulate the maturation of monocyte-derived dendritic cells (DC). The question of how leukemic cells especially in monocytic lineage respond to GL-PS stimuli remains unclear. Results: In this study, we used in vitro culture model with leukemic monocytic cell-lines THP-1 and U937 as monocytic effectors cells for proliferation responses and DCs induction. We treated the THP-1 and U937 cells with purified GL-PS (100 μg/mL) or GL-PS with GM-CSF/IL-4. GL-PS alone induced proliferative response on both THP-1 and U937 cells but only THP-1 transformed into typical DC morphology when stimulated with GL-PS plus GM-CSF/IL-4. The transformed THP-1 DCs had significant increase expression of HLA-DR, CD40, CD80 and CD86 though not as high as the extent of normal monocyte-derived DCs. They had similar antigen-uptake ability as the normal monocyte-derived DCs positive control. However, their potency in inducing allogeneic T cell proliferation was also less than that of normal monocyte-derived DCs. Conclusion: Our findings suggested that GL-PS could induce selected monocytic leukemic cell differentiation into DCs with immuno-stimulatory function. The possible clinical impact of using this commonly used medicinal mushroom in patients with monocytic leukemia (AML-M4 and M5) deserved further investigation. Background In both Western and Oriental societies, cancer patients commonly take complementary and alternative medicine while they underwent conventional anti-cancer therapy [1-3]. Among different kinds of alternative medicine, herbal medicine is the most popular form taken by patients in United Kingdom [4]. In our community, more than 42% of our pediatric cancer patients took herbal medicine when they received conventional chemotherapy [5]. Among them, the commonest herb being used is the extracts derived from Ganoderma lucidum. Ganoderma lucidum (GL) is a traditional Chinese medicine known by the layman as the "herb of immortality". It was Published: 21 July 2008 Journal of Hematology & Oncology 2008, 1:9 doi:10 .1186 /1756 -8722 -1-9 Received: 13 May 2008 Accepted: 21 July 2008 This article is available from: http://www.jhoonline.org/content/ 1/1/9 © 2008 Chan et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0 ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Page 1: Ganoderma Lucidum Polysaccharides Can Induce Human Monocytic

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