gastroscope advisor: dr. ata akin design team: casey gavinski kenneth hoyt ashish patel kalpesh...
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GastroscopeGastroscopeAdvisor:Advisor:Dr. Ata AkinDr. Ata Akin
Design Team:Design Team:Casey GavinskiCasey Gavinski
Kenneth HoytKenneth Hoyt
Ashish PatelAshish Patel
Kalpesh TrivediKalpesh Trivedi
Problem BackgroundProblem Background
Diabetes Mellitus Gastroparesis Techniques for Diagnosis
InvasiveNon-invasive
Methods of DiagnosisMethods of Diagnosis
Nuclear Medicine TestPatient consumes small amount of radioactive materialScanner monitors amount of radioactivity in stomach
Upper Gastrointestinal (GI) Endoscopy TestCamera inserted into digestive tractVisually examines stomach
Intraluminal ManometryBaloon inserted into stomachMeasures pressure generated by stomach contractions
Electrogastrography (EGG)
Invasive
ElectrogastrographyElectrogastrography Measurement of Gastric Myoelectrical
Potential SignalsElectrodes placed on abdominal surfaceTesting performed during states of
Fasting and PostprandialCorrelation between EGG signals
and gastric motility
Non-Invasive !!
EGG SignalEGG Signal
Gastric Myoelectrical Signals (500μV)
0 20 40 60 80 100 120
-0.2
-0.1
0
0.1
0.2
0.3
0.4
Time (sec)
Am
plit
ud
e (
mV
)
Internal EGG Measurement
0 20 40 60 80 100 120
-0.2
-0.1
0
0.1
0.2
0.3
0.4
Time (sec)
Am
plit
ud
e (
mV
)
Surface EGG Measurement
EGG SignalEGG Signal
Primary Frequency Component3 cpm (0.05 Hz)
0 50 100 1500
1
2
3
4
5
6
7
8
9
Ma
gn
itu
de
Frequency (cpm)
Existing EGG SystemsExisting EGG Systems Signal Measurement Bandwidth
1-18 cpm (0.02-0.3 Hz)Primary Frequency
Stand AloneMobility Limited
PortableNo Graphical DisplayNot Stand Alone
GastroscopeGastroscope
Portable Stand Alone System Graphical Display Increased Bandwidth
0 50 100 1500
1
2
3
4
5
6
7
8
9
Ma
gn
itu
de
Frequency (cpm)
EGG SignalEGG Signal
Secondary Frequency Component50 – 80 cpm (0.8 – 1.3 Hz)
Why the 50 to 80 cpm ?Why the 50 to 80 cpm ?
3cpm range requires monitoring throughout fasting and postprandial states. (Differential Comparisons)
50 to 80 cpm range provides consistent results with a short time reading.
50 to 80 cpm range closely correlated to Intraluminal Manometry Test in dogs. (Diagnostic Charts Available)
Create look-up charts for faster more accurate diagnosis.
Gastroscope System ArchitectureGastroscope System Architecture
Laptop(LabVIEW)
Spreadsheet(Excel)
Amplifier FiterFunction
Generator
DAQ
Analog Signal ProcessingAnalog Signal Processing
DC AmplifierInstrumentation AmplifierGain > 10,000Low Noise
FilterLow PassFlat ResponseSharp Roll-off
Amplifier SchematicAmplifier Schematic
kR
FC
Hzfc
RCfc
2.8
1
20
2
1
VV
VV
RcRc
kGain
15
15
510
10050
1
OUTPUT
V -
V + V +
V -
+ INA121
_Rc
+ INA121
_RcINPUT
V +
V -
C
+ OPA2131A
_R
R
C
V +
V -
C
+ OPA2131A
_
R
C
ROUTPUT
Printed Circuit Board (PCB)Printed Circuit Board (PCB)
Amplifier ResponseAmplifier Response
Amplifier and filter response to an input of 100 μv at 1 Hz
Amplifier Response (Cont’d)Amplifier Response (Cont’d)
Amplifier and filter response to an input of 100 μv at 15 Hz
Amplifier Response (Cont’d)Amplifier Response (Cont’d)
Amplifier and filter response to an input of 1 mv at 1 Hz
Amplifier Response (Cont’d)Amplifier Response (Cont’d)
Amplifier and filter response to an input of 1 mv at 15 Hz
DSP Flow ChartDSP Flow Chart
Hanning Windowing
Mean Subtraction
Power
Peak Detectionand
CorrespondingFrequency
Display and Memory
Primary Signal3 cpm
(0.05 Hz)
Secondary Signal50 - 80 cpm
(0.83 - 1.33 Hz)
Fast FourierTransform
Window Averaging
EGG Signal
Data Windowing
Matlab SimulationMatlab Simulation
10 20 30 40 50 60 70 80 90 100 110 1200
5
10
15
Frequency (cpm)
Ma
gn
itu
de
Fasting State Postprandial State
Matlab Simulation (Cont’d)Matlab Simulation (Cont’d)
0 50 100 1500
0.5
1
1.5
2
2.5
3M
ag
nit
ud
e
Frequency (cpm)
Fasting State Postprandial State
Laptop Based DesignNear Real Time Data AnalysisLabVIEW SoftwareData Storage in Spreadsheet FormatGUI InterfacePortableResearch Applications
• IRB Approved
Alternative System DesignAlternative System Design
Future WorkFuture Work
Integrated System DSP Based Architecture Properly Configured ADC Touchscreen Display (LCD)
Senior Design ExpendituresSenior Design Expenditures
Component CostPrinted Circuit Board (PCB) $20
Integrated Circuits NAShielded Electrode Lead Assembly $125
Large Electrodes (50) $35DSP Workshop/Starter Kits $700
Misc. Hardware $40Labtop Computer NA
LabVIEW Software NADAQ Card-AI-16E-4 NA
Total Cost $920
4 Year Financial Estimation4 Year Financial Estimation
Role Appoint Effort Year 1 Year 2 Year 3 Year4 TotalEngineer 4 100% $30,000 $31,500 $33,075 $34,729 $129,304Subtotal $120,000 $126,000 $132,300 $138,915 $517,215
Overhead and Benefits @ 100% 100.00% $120,000 $126,000 $132,300 $138,915 $517,215Product Manufacturing ($600/unit) $12,000 $18,000 $24,000 $30,000 $84,000Supplies $500 $500 $500 $500 $2,000Equipment $15,000 $2,000 $2,000 $2,000 $21,000Travel $5,000 $5,000 $5,000 $5,000 $20,000Total Cost for Production $272,500 $277,500 $296,100 $315,330 $1,161,430
Unit Price $13,625 $9,250 $7,403 $6,307
Note: Production at $600 per unit is assumed as follows Year 1 – 20 units Year 2 – 30 units Year 3 – 40 units Year 4 – 50 units
National InstrumentsDAQ AI 16EAmplifier Fiter
EGG SYSTEM
0 50 100 1500
1
2
3
4
5
6
7
8
9
Mag
nitu
de
Frequency (cpm)
START
Freq =
Mag =
Power =
Laptop
STOP RESETSUMMARY
Summary of System DesignSummary of System Design