Gene Therapy—the

Application of

Adenovirus Vectors

Prepared by

Creative Biogene

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• In terms of genetic defect,

abnormal genome is the bad

source. If we could find the

exact abnormal part and fix it,

then the illness could be

avoided, at least theoretically.

• With thinking the same, many

attempts have been made to

treat the disorders by adding

back the correct genetic

information to individual cells.

This is what we are going to talk

today—gene therapy by adding

foreign genetic material to treat

disorders under this setting.

• Dating back to 1970s the

conceptual emerging, gene

therapy trials used to treat

human disorders actually really

started after twenty years.

However like every new thing

stumbles, these initial trials did

not add color to this exciting and

promising field, might because

of short of background and

related knowledge. So the

results at that time were initial

dramatic clinical failures.

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• With the development of

technology and constant

accumulation of

understanding, people

begun to think about an

alternate—if we want the

gene therapy to work, the

correct genetic information

has to be packaged and

delivered to target cells,

but how?

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The answer is adenovirus

vectors. Adenoviral

packaging vectors are

attractive options for its

unique features:

• Low pathogenicity,

• High viral yields,

• Carry large genes, and

• Have transgene specific B

and T cell responses

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• In addition to this, when packaged

with recognizable antigens from

various diseases, adenovirus

vectors may serve as vaccines.

Novel vaccines targeting complex

pathogens like HIV, HCV, TB,

malaria, influenza as well as cancer

is a long-standing goal of human

gene therapy.

• A team of scientists from Creative

Biogene has developed exclusive

techniques in adenovirus vector

design and construction, as well as

the generation of the adenovirus in

high titer. With unique processes for

the generation of new adenovirus

constructs, Creative Biogene can

provide the fastest turn-around time

of any supplier in the industry.

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The services

include:

• Clone gene of interest into

appropriate transfer vector.

• Transfect HEK 293 cells with

recombinant viral DNA to

produce recombinant

adenoviruses.

• Create high-titer recombinant

adenovirus stock.

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Contact to order

• USA

45-1 Ramsey Road, Shirley, NY

11967, USA

Tel: 1-631-626-9181

Email：info@creative-biogene.com

United Kingdom

St John's Innovation Centre,

Cowley Road, Cambridge CB4

0WS, UK

Tel: 44-207-048-3343

Email：info@creative-biogene.com

• Web: http://www.creative-

biogene.com/Services/Custom-

Viral-Service/Adenovirus-

service.html

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