1. Generic Rheumatrex TabletsGeneric Rheumatrex Tablets (Neotrexate Tablets)is an antimetabolite and antifolate drug. It is usedin treatment of cancer, neoplastic diseases, severepsoriasis, autoimmune diseases, ectopicpregnancy, Eczema, Lymphoma, TrophoblasticDisease and adult rheumatoid arthritis. The Swiss Pharmacy, Geneva Switzerland

2. Generic Rheumatrex TabletsChemical Structure The Swiss Pharmacy, Geneva Switzerland 3. Generic Rheumatrex TabletsActive IngredientThe active pharmaceutical ingredientcontained in Generic Rheumatrex(Neotrexate Tablets) is Methotrexate. The Swiss Pharmacy, Geneva Switzerland 4. Generic Rheumatrex TabletsRecommended DosageThe dosage of Generic Rheumatrex (NeotrexateTablets) is different for different diseases andtreatments. The adult dosage for some indications isgiven below:Choriocarcinoma and Similar TrophoblasticDiseases:Methotrexate is administered orally in doses of 15 to30 mg daily for a five-day course. Suchcourses are usually repeated for 3 to 5 times asrequired, with rest periods of one or more weeksinterposed between courses, until any manifestingtoxic symptoms subside. The Swiss Pharmacy, Geneva Switzerland 5. Generic Rheumatrex TabletsRecommended DosageAdult Rheumatoid Arthritis:Recommended Starting Dosage Schedules1. Single oral doses of 7.5 mg once weekly.2. Divided oral dosages of 2.5 mg at 12 hourintervals for 3 doses given as a course once weeklyPolyarticular-Course Juvenile RheumatoidArthritis:The recommended starting dose is 10 mg/m2 givenonce weekly The Swiss Pharmacy, Geneva Switzerland 6. Generic Rheumatrex TabletsContraindicationsGeneric Rheumatrex (Neotrexate Tablets) iscontraindicated in patients with the followingconditions:Hypersensitivity to Methotrexate , or anyinactive component of this medication.In pregnant women with psoriasis or rheumatoidarthritis as Methotrexate can cause fetal death orteratogenic effects when administered to apregnant woman.In nursing mothers due to potential for seriousadverse reactions from methotrexate in breast fedinfants. The Swiss Pharmacy, Geneva Switzerland 7. Generic Rheumatrex TabletsContraindicationsPatients with psoriasis or rheumatoid arthritis withalcoholism, alcoholic liver disease or other chronicliver disease should not receive methotrexate(Neotrexate Tablets).Patients with psoriasis or rheumatoid arthritis whohave overt or laboratory evidence ofimmunodeficiency syndromes should not receivemethotrexate.Patients with psoriasis or rheumatoid arthritis whohave preexisting blood dyscrasias, such as bonemarrow hypoplasia, leukopenia, thrombocytopeniaor significant anemia,should not receivemethotrexate (Generic Rheumatrex). The Swiss Pharmacy, Geneva Switzerland 8. Generic Rheumatrex TabletsSide Effects of Generic Rheumatrex(Neotrexate Tablets)The most frequent side effects includeulcerative stomatitis, leukopenia,nausea, and abdominal distress.Other commonly reported side effectsare malaise, undue fatigue, chills andfever, dizziness and decreasedresistance to infection. The Swiss Pharmacy, Geneva Switzerland 9. Generic Rheumatrex TabletsWarnings And PrecautionsThe patient should be fully informed of the risksinvolved and should be under constantsupervision of the physician. Methotrexate has thepotential for serious toxicity.Assessment of hematologic, hepatic, renal, andpulmonary function should be made by history,physical examination, and laboratory tests beforebeginning, periodically during, and beforereinstituting methotrexate therapy. The Swiss Pharmacy, Geneva Switzerland 10. Generic Rheumatrex TabletsWarnings And PrecautionsToxic effects may be related in frequency andseverity to dose or frequency of administration buthave been seen at all dosesMost adverse reactions are reversible if detectedearly. When adverse reactions occur, GenericRheumatrex (Neotrexate Tablets) should bereduced in dosage or discontinued andappropriate corrective measures should be taken The Swiss Pharmacy, Geneva Switzerland 11. Generic Rheumatrex TabletsOverdose SymptomsSymptoms commonly reported following oraloverdose of Generic Rheumatrex (NeotrexateTablets) include leukopenia, thrombocytopenia,anemia, pancytopenia, bone marrow suppression,mucositis, stomatitis, oral ulceration, nausea,vomiting, gastrointestinal ulceration,gastrointestinal bleeding.There have been reports of death followingovedose. In these cases, events such as sepsisor septic shock, renal failure, and aplastic anemiawere also reported. The Swiss Pharmacy, Geneva Switzerland 12. Generic Rheumatrex TabletsOverdose TreatmentLeucovorin is used to diminish the toxicity andcounteract the effect of inadvertentlyadministered overdosages of methotrexate.Leucovorin should be administered to the patientas soon as possible because as the time intervalbetween methotrexate administration andleucovorin initiation increases, the effectivenessof leucovorin in counteracting toxicity decreases. The Swiss Pharmacy, Geneva Switzerland 13. Generic Rheumatrex TabletsOverdose TreatmentIn cases of massive overdosage, hydrationand urinary alkalinization may benecessary to prevent the precipitation ofmethotrexate and/or its metabolites in therenal tubules.Effective clearance of methotrexate hasbeen reported with acute, intermittenthemodialysis using a high-flux dialyzer. The Swiss Pharmacy, Geneva Switzerland 14. Generic Rheumatrex TabletsNeotrexate Tablets Manufacturedby GlaxoSmithKline IndiaFor more information click here The Swiss Pharmacy, Geneva Switzerland