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Global Aesthetic Market XIV June 2016

www.miinews.com Medical Insight, Inc. 2

M.I.I Disclaimer

Information in this study has been obtained by Medical Insight, Inc., from sources believed to be reliable. While Medical Insight believes the data provided herein to be accurate, no expressed or implied guarantees regarding accuracy or adequacy are made. Product and corporate data can change very quickly and without notice and Medical Insight continually updates its research products. Because of this, certain figures in Medical Insight reports may differ from corresponding figures in earlier reports, even if those reports were issued relatively recently. Furthermore, current economic conditions are contributing to a highly volatile market, in which actual results often diverge significantly from estimates developed by manufacturers, analysts and others, resulting in a revision of projections. Therefore, while Medical Insight will provide an explanation of figures in any of its reports, only the most recent reports contain Medical Insight’s latest estimates.

This study is not intended as a substitute for proper due diligence. Although an attempt has been made to provide thorough coverage of the subject matter of this report, no guarantees regarding completeness or thoroughness are made. Medical Insight is not responsible for any errors, omissions, or results obtained from use of information provided herein.

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M.I.I Professional Biography

Michael Moretti President Medical Insight, Inc.

Michael Moretti has served as a medical industry analyst and strategic advisor for more than 20 years. As an industry consultant, Mr. Moretti specializes in strategic business development projects and high-growth, emerging market segments. He provides custom reports and confidential market studies for a variety of clients, including global medical and pharmaceutical companies.

In 1993, Mr. Moretti founded Medical Insight, Inc., the leader in focused aesthetic market

research offering comprehensive data on procedure volume and growth, revenue forecasts and new product introductions. Under Mr. Moretti’s leadership, Medical Insight publishes global market studies and forecasts for major industry sectors such as facial injectables, cosmeceuticals, body shaping procedures, skin rejuvenation technologies and home-use aesthetic products. Medical Insight also sponsors executive business forums to address scientific developments and market trends for the investment community.

Mr. Moretti is the founder of Aesthetic TV, the first and only one-stop online resource for

current, reliable information about cosmetic and anti-aging treatments. Aesthetic TV offers expert advice for consumers via interviews with the top physicians in the field, and unprecedented access to the latest beauty-enhancing procedures and products created specifically to help people look and feel their absolute best.

Mr. Moretti is also founder and publisher of THE Aesthetic Guide® – a digital and print

publication from Medical Insight featuring in-depth reports on new products, procedures and trends, reaching over 75,000 physicians, industry executives and investment analyst subscribers globally. Special editions of THE Aesthetic Guide address the European and Asian markets.

In 2007, Mr. Moretti debuted THE Aesthetic Show™, the first multidisciplinary annual business

to business trade show that brings thousands of the highest profile physicians and medical professionals together in Las Vegas to learn about the newest aesthetic procedures, products and technologies in a dynamic, interactive, educational format. For more information please visit: www.miinews.com. Contact Information: Michael Moretti Medical Insight, Inc. 130 Vantis, Suite 240 Aliso Viejo, CA 92656 USA +1 (949) 830-5409 telephone +1 (949) 830-8944 facsimile Email: [email protected] Or visit the Medical Insight website at: www.miinews.com





M.I.I Table of Contents

Disclaimer 2

Professional Biography 3

Table of Contents 4

Table of Exhibits 17

1.0 Executive Summary 28

2.0 Background 30

2.1 The Aging Process 30

2.1.1 Free Radical Theory 30

2.1.2 Inflammation 31

2.1.3 Immune System Response 31

3.0 Energy-Based Devices and Treatments 33

3.1 Overview of Energy Types and Treatments 33

3.1.1 Laser Devices 36

3.1.2 Intense Pulsed Light 37

3.1.3 Light-Emitting Diodes 37

3.1.4 Light Heat Energy 37

3.1.5 Energy-Based Epilation 37

3.1.6 Skin Rejuvenation 38

3.1.7 Tattoo & Pigmented Lesion Removal 40

3.1.8 Acne Reduction 42

3.1.9 Vascular Lesions 42

3.2 Competitive Advantage 43



3.2.3 Tattoo and Pigmented Lesion Removal 47


3.2.5 Treatment of Vascular Lesions 48

3.3 Device Descriptions and Results 49


3.3.1.1 Alexandrite Lasers 53




3.3.1.2 Diode Lasers 54

3.3.1.3 Nd:YAG Lasers 54

3.3.1.4 Pulsed Light Devices 55

3.3.1.5 Electro-Optical Synergy 55


3.3.2.1 Ablative Skin Rejuvenation 59

3.3.2.2 Non-Ablative Skin Rejuvenation 59

3.3.2.3 Fractional Skin Rejuvenation 59

3.3.3 Tattoo and Pigmented Lesion Removal 63


3.3.4.1 Bactericidal Approach 66

3.3.4.2 Cessation of Oil Porduction Appraoch 67

3.3.4.3 Photopneumatic 67

3.3.5 Vaginal Rejuvenation 68

3.3.6 Vascular Lesions 69

3.4 Manufacturer Profiles 72

3.4.1 Alma Lasers 72

3.4.2 AMT Engineering 75

3.4.3 BTL Aesthetics 76

3.4.4 Cutera 77

3.4.5 Cynosure 78

3.4.6 EL.EN. Group 81

3.4.7 Ellipse 83

3.4.8 EndyMed 83

3.4.9 Energist 84

3.4.10 Focus Medical 85

3.4.11 Fotona 85

3.4.12 General Project 87

3.4.13 Hironic 87

3.4.14 ILOODA 88

3.4.15 InMode 88

3.4.16 Jeisys 89

3.4.17 LASERING 89

3.4.18 Lumenis 90

3.4.19 Lutronic 92

3.4.20 Medicol USA 93




3.4.21 Meditime 93

3.4.22 MedixSysteme 94

3.4.23 Pantec Biosolutions 94

3.4.24 Perfaction 94

3.4.25 Pollogen 95

3.4.26 Protocadmus 96

3.4.27 Radiancy / PhotoMedex 96

3.4.28 Sciton 97

3.4.29 SharpLight 99

3.4.30 Solta / Valeant 100

3.4.31 SupraMedical 101

3.4.32 Syneron Candela 102

3.4.33 Thermi 104

3.4.34 Viora 105

3.4.35 Viveve Medical 106

3.5 Equipment Sales Estimates 2015 – 2020 107

3.5.1 Platforms 108

3.5.2 Disposables 122

3.6 Treatment Volume Estimates 2015 – 2020 130

3.7 Competitive Analysis and Market Share 143

4.0 Body Shaping & Skin Tightening 145

4.1 Overview of Condition and Treatment 145


4.3 Device Descriptions and Results 149



4.4.2 Andrew Technologies 154

4.4.3 BTL Industries 154

4.4.4 CAREstream America 155

4.4.5 Chromogenex 156

4.4.6 Classys 157

4.4.7 Cutera 157

4.4.8 Cynosure 158

4.4.9 EL.EN Group (Asclepion, DEKA, Quanta System) 160




4.4.10 EndyMed 161

4.4.11 Energist 163

4.4.12 Erchonia 163

4.4.13 EunSung Global Corp. 164

4.4.14 Fotona 166

4.4.15 General Project 166

4.4.16 Grupo Body Esthetic Laboratories 167

4.4.17 Hironic 168

4.4.18 InMode 168

4.4.19 Jeisys 169

4.4.20 LoveLite Ltd. 170

4.4.21 Lutronic 170

4.4.22 Meditime 171

4.4.23 MedixSysteme 171

4.4.24 Merz (Ulthera) 173

4.4.25 Perigee Medical 174

4.4.26 Pollogen 174

4.4.27 Protocadmus Technologies 176

4.4.28 Sciton 176

4.4.29 SharpLight Technologies 177

4.4.30 Shenzhen GSD Tech 177

4.4.31 Silhouet-Tone 178

4.4.32 STORZ Medical 178

4.4.33 Strawberry Laser Lipo 179

4.4.34 Syneron 178

4.4.35 ThermaMedic 181

4.4.36 Thermi 182

4.4.37 Valeant (Solta Medical) 183

4.4.38 Venus Concept 186

4.4.39 Viora 186

4.4.40 ZELTIQ Aesthetics 187

4.4.41 Zimmer MedizinSysteme 190

4.5 Equipment Sales Estimates 2015 to 2020 191

4.5.1 Platforms 191

4.5.2 Disposable 203




4.6 Treatment Volume Estimates 2015 to 2020 214


5.0 Neurotoxins 224



5.3 Product Descriptions and Results 227

5.3.1 BTX-A 228

5.3.2 BTX-B 229


5.4.1 Allergan 230

5.4.2 ALPHAEON Corp. 234

5.4.3 Daewoong Pharma 234

5.4.4 Ipsen 235

5.4.5 Galderma 235

5.4.6 HuGel 237

5.4.7 Lanzhou Institute 237

5.4.8 MedyTox 238

5.4.9 Merz 239

5.4.10 Revance Therapeutics 240

5.5 Product Sales Estimates 2015 to 2020 242



6.0 Dermal Fillers 261

6.1 Overview of Conditions and Treatments 261




6.4.1 Adoderm 268

6.4.2 Aesthetic Factors 269

6.4.3 Allergan 269


6.4.5 Biologica Tech 270

6.4.6 Bloomage 270




6.4.7 CM Aesthetic 271

6.4.8 Contura / Specialty European Pharma 271

6.4.9 Cosmoscience 272

6.4.10 Croma-Pharma 273

6.4.11 Fibrocell 273

6.4.12 Laboratoires FILORGA 274

6.4.13 Galderma 274

6.4.14 Hangzhou Gallop Biological Products 276

6.4.15 Hangzhou Sinclean Medical Products 276

6.4.16 Harvest Technologies Corp. 277

6.4.17 IBSA Farmaceutici Italia 277

6.4.18 Kaylight 278

6.4.19 LG Life Sciences 279

6.4.20 Merz Aesthetics 279

6.4.21 NovoNexus 280

6.4.22 O’Meiye Group 280

6.4.23 Procytech / The Cell Bio-Tech (China) 280

6.4.24 Prollenium Medical Technologies 281

6.4.25 RegenLab 281

6.4.26 Regenyal 281

6.4.27 Revitacare 282

6.4.28 SBS-Med 283

6.4.29 Sinclair Pharma 283

6.4.30 Suiselle 285

6.4.31 Suneva Medical 285

6.4.32 Teoxane 287

6.4.33 Vivacy 288

6.4.34 Zimmer MedizinSysteme 289




7.0 Liposuction 309








7.4.1 Mentor 312

7.4.2 MicroAire 312

7.4.3 Valeant 312

7.4.4 Wells Johnson 313


7.6 Prcedure Volume 325


8.0 Breast Implants 331




8.3.1 Saline Implants 334

8.3.2 Silicone Implants 335


8.4.1 Allergan 337

8.4.2 GC Aesthetics 338

8.4.3 Mentor 339

8.4.4 PIP 340

8.4.5 Sientra 341

8.4.6 Silimed 342

8.4.7 Valeant 343


8.6 Procedure Volume 356


9.0 Physician-Dispensed Topicals, Peels and Eyelash Products 362




9.3.1 Ingredients 370

9.3.1.1 Vitamin A and Retinoids 371

9.3.1.2 Vitamin C 371




9.3.1.3 Vitamin E 372

9.3.1.4 Alpha Lipoic Acid 372

9.3.1.5 Coenzyme Q10 373

9.3.1.6 Aminophylline 374

9.3.1.7 Argirelene 375

9.3.1.8 Beta Hydroxy Acids 375

9.3.1.9 Ceramides 375

9.3.1.10 Coconut Oil 376

9.3.1.11 Coenzyme Q10 376

9.3.1.12 Creatine 377

9.3.1.13 Cytokinin & Zeatin 377

9.1.3.14 DMAE 377

9.1.3.15 Epigallocatechin Gallate 378

9.1.3.16 Growth Factors 378

9.1.3.17 Hyaluronic Acid 379

9.1.3.18 Idebenone 379

9.1.3.19 Melanozyme 380

9.1.3.20 Peptides 380

9.1.3.21 Silica Silylate 381

9.3.1.22 Latest Developments in Formulations 381

9.3.2 Chemical Peels 387

9.3.3 Eyelash Products 391

9.3.4 Scar Products 393

9.3.5 Skin Lightening / Brightening 394

9.3.6 Sunscreens 395


9.4.1 A Plus Medical 398

9.4.2 Alastin Skincare 398

9.4.3 Allergan 399


9.4.5 Athena Cosmetics 402

9.4.6 Biodermis 403

9.4.7 BiON Research 403




9.4.8 Biopelle 403

9.4.9 Cellese 404

9.4.10 Celuvia 404

9.4.11 Clinicians Complex 404

9.4.12 Cosmederm Bioscience 405

9.4.13 Cosmedical Technologies 405

9.4.14 Cutagenesis 405

9.4.15 Derma e 405

9.4.16 Dermaesthetics 406

9.4.17 Dermamedics 406

9.4.18 Dermaquest 406

9.4.19 DermAware 406

9.4.20 Derme&Co. 407

9.4.21 DermWORX 407

9.4.22 Enaltus 407

9.4.23 Enhance Skin Products 408

9.4.24 Environ 408

9.4.25 Envy Medical 408

9.4.26 EltaMD 409

9.4.27 Epikinetics 410

9.4.28 Episciences 410

9.4.29 Eraclea 410

9.4.30 exCel Cosmeceuticals 411

9.4.31 Fallene 411

9.4.32 Laboratoires Filorga 412

9.4.33 Galderma 412

9.4.34 glo Professional 413

9.4.35 GMC Medical 413

9.4.36 Hale Cosmeceuticals 413

9.4.37 Hand MD 413

9.4.38 HydroPeptide 414

9.4.39 Illuminare Skincare 414

9.4.40 INNOCUTIS 414




9.4.41 Innovative Skincare 415

9.4.42 Intrafusions 415

9.4.43 Jan Marini 415

9.4.44 LA Canada Ventures 416

9.4.45 La-Roche Posay 417

9.4.46 LEIO Corporation 418

9.4.47 LifeLine Skincare 418

9.4.48 LIFTLAB 418

9.4.49 Lira Cosmeceuticals 419

9.4.50 MD Formulations 419

9.4.51 Medicalia 420

9.4.52 Mesoestetic Pharma Group 420

9.4.53 Murad 420

9.4.54 Mybody 421

9.4.55 mySkin 422

9.4.56 Neocutis (Merz) 423

9.4.57 NeoStrata 423

9.4.58 NewMedical Technology 423

9.4.59 Niadyne Pharma 424

9.4.60 Novo Solutions 424

9.4.61 NuGene International 425

9.4.62 NuvesseMD 425

9.4.63 Obagi Medical (Valeant) 425

9.4.64 Osmosis Pur Medical Skincare 426

9.4.65 Oxygenetix Institute 427

9.4.66 PCA SKIN 427

9.4.67 Pevonia 427

9.4.68 PhotoMedex 427

9.4.69 PhytoCeuticals 428

9.4.70 Pierre Fabre 429

9.4.71 Revision Skincare 429

9.4.72 SAIAN 429

9.4.73 Scar Heal 430




9.4.74 Scarguard Labs 430

9.4.75 Sente 430

9.4.76 Sesderma 431

9.4.77 SkinCeuticals (L’Oreal) 431

9.4.78 Skinprint 432

9.4.79 Suneva Medical 432

9.4.80 Syneron 432

9.4.81 Teoxane 433

9.4.82 Therapon 434

9.4.83 Topokine Therapeutics (Allergan) 434

9.4.84 Turo Skin 435

9.4.85 US CosmeceuTechs 435

9.4.86 Venus Skin 435

9.4.87 Young Pharmaceuticals 435

9.4.88 ZO Skin Health 436



10.0 Emerging Technologies 451



10..3 Manufacturer Profiles and Product Descriptions 455

10.3.1 Allergan 455


10.3.3 Croma-Pharma 457

10.3.4 Excaliard Pharmaceuticals / Pfizer 457

10.3.5 Halscion 458

10.3.6 Jeisys 458

10.3.7 Miramar Labs 459

10.3.8 Neothetics (formerly Lithera) 460

10.3.9 NovaThreads / CosmoFrance 460

10.3.10 Revance Therapeutics 461

10.3.11 Sinclair 462

10.3.12 V SoftLift AB 463




10.3.13 Viviscal 463


11.0 Home-Use Devices 466





11.4.1 Apira 472

11.4.2 Beautyko 473

11.4.3 Biotechnique Avance 473

11.4.4 Carol Cole Company 474

11.4.5 DermaConcepts 474

11.4.6 Evis Beauty 475

11.4.7 evoDerma 475

11.4.8 Freedom Laser Therapy 476

11.4.9 Guangzhou Charming Electronic Company 476

11.4.10 Home Skinovations 476

11.4.11 Illuminage Beauty 477

11.4.12 JeNu Biosciences 478

11.4.13 LaserCap Company 479

11.4.14 Lexington International 479

11.4.15 Light4Beauty 481

11.4.16 L’Oreal 481

11.4.17 nanoTime 482

11.4.18 Philips 483

11.4.19 PhotoMedex 484

11.4.20 Pollogen 485

11.4.21 Quasar Biotech 486

11.4.22 Reckitt Benckiser 486

11.4.23 Rio (Dezac Group) 486

11.4.24 Spectrum Brands / Remington 487

11.4.25 Spencer Forrest 488




11.4.26 Super Grow Lasers 488

11.4.27 Theradome 489

11.4.28 Tria Beauty 489

11.5 Market Forecasts 490

12.0 Total Market 498

12.1 Total Market 498

12.2 Procedure Volume and Fees 509

12.3 Market Share 511

13.0 Aesthetic Practice Trends 514

I Treatment Comparison 567

I.I Perceived Value 540

I.II Safety vs. Efficacy 544

I.III Treatment Compatibility 547

I.IV Non-Physician Performed Treatments 548

II Company Listings 574




M.I.I. Table Of Exhibits

Table 3-1 Energy-Based Types 34

Table 3-2 Average Electolysis Treatment Times 43

Table 3-3 Laws Related to Operation of Laser Hair Removal Devices by State 45

Table 3-4 Top Energy-Based Hair Removal Devices 51

Table 3-5 Top Skin Rejuvenation Devices 56

Table 3-6 Fractional Skin Rejuvenation Devices 61

Table 3-7 Top Tattoo and Pigmented Lesion Removal Devices 63

Table 3-8 Top Energy-Based Acne Devices 65

Table 3-9 Top Energy-Based Vaginal Rejuvenation Devices 68

Table 3-10 Top Energy-Based Vascular Lesion Removal Devices 70

Table 3-11

Worldwide Projected Dollar Sales for Top Manufacturers of Energy-Based Device Platforms

108

Figure 3-1

Worldwide Dollar Growth for Leading Providers of Energy-Based Device Platforms

109

Table 3-12

North American Projected Dollar Sales for Top Manufacturers of Energy-Based Device Platforms

110

Figure 3-2

North American Dollar Growth for Leading Providers of Energy-Based Device Platforms

111

Table 3-13

European Projected Dollar Sales for Top Manufacturers of Energy-Based Device Platforms

112

Figure 3-3

European Dollar Growth for Leading Providers of Energy-Based Device Platforms

113

Table 3-14

Asian Projected Dollar Sales for Top Manufacturers of Energy-Based Device Platforms

115

Figure 3-4 Asian Dollar Growth for Leading Providers of Energy-Based Device Platforms 116

Table 3-15

Latin American Projected Dollar Sales for Top Manufacturers of Energy-Based Device Platforms

117

Figure 3-5

Latin American Dollar Growth for Leading Providers of Energy-Based Device Platforms

118

Figure 3-6 Dollar Sales of Energy-Based Device Platforms by Region 119

Table 3-16

Worldwide Projected Dollar Sales for Energy-Based Device Platforms, by Application

120

Figure 3-7 Dollar Sales of Energy-Based Device Platforms, by Application 121

Table 3-17

Worldwide Projected Dollar Sales for Top Manufacturers of Energy-Based Device Disposables

122




Figure 3-8 Worldwide Dollar Sales of Energy-Based Device Disposables 123

Table 3-18

North American Projected Dollar Sales for Top Manufacturers of Energy-Based Device Disposables

123

Figure 3-9 North American Dollar Sales of Energy-Based Device Dispoables 124

Table 3-19

European Projected Dollar Sales for Top Manufacturers of Energy-Based Device Disposables

125

Figure 3-10 European Dollar Sales of Energy-Based Device Disposables 126

Table 3-20

Asian Projected Dollar Sales for Top Manufacturers of Energy-Based Device Disposables

126

Figure 3-11 Asian Dollar Sales of Energy-based Device Disposables 127

Table 3-21

Latin American Projected Dollar Sales for Top Manufacturers of Energy-Based Device Disposables

127

Figure 3-12 Latin American Dollar Sales of Energy-Based Device Disposables 128

Figure 3-13 Dollar Sales of Energy-Based Device Disposables, by Region 129

Table 3-22 Worldwide Procedure Volume for Energy-Based Aesthetic Treatments 130

Figure 3-14 Worldwide Procedure Fees for Energy-Based Aesthetic Treatments 131

Figure 3-15

Worldwide Procedure Volume for Energy-Based Aesthetic Treatments by Region

132

Figure 3-16 Worldwide Procedure Fees for Energy-Based Aesthetic Treatments by Region 133

Table 3-23

Worldwide Procedure Volume for Energy-Based Aesthetic Treatments by Application

134

Figure 3-17

Worldwide Procedure Volume for Energy-Based Aesthetic Treatments by Application

135

Table 3-24

Worldwide Procedure Fees for Energy-Based Aesthetic Treatments by Application

136

Figure 3-18

Worldwide Procedure Fees for Energy-Based Aesthetic Treatments by Application

136

Figure 3-19 Average Number of Weekly Energy-Based Hair Removal Treatments 137

Figure 3-20 Average Charge for Single Energy-Based Hair Remvoal Treatment 138

Figure 3-21 Average Number of Weekly Energy-Based Skin Rejuvenation Treatments 139

Figure 3-22 Average Charge for Single Energy-Based Skin Rejuvenation Treatment 140

Figure 3-23 Average Number of Weekly Energy-Based Feminine Rejuvenation Treatments 141

Figure 3-24 Average Charge for a Single Energy-Based Feminine Rejuvenation Treatment 142

Table 3-25

Market Shares of Leading Manufacturers of Energy-Based Aesthetic Platforms and Disposables

143

Figure 3-25

Market Shares for Leading Manufacturers of Energy-Based Aesthetic Equipment

144

Table 4-1 Leading Body Shaping and/or Cellulite Reduction Devices 149

Table 4-2 Leading Skin Tightening Devices 152




Table 4-3

Worldwide Projected Dollar Sales for Top Manufacturers of Body Shaping & Skin Tightening Device Platforms

192

Figure 4-1 Worldwide Sales Growth of Body Shaping & Skin Tightening Platforms 193

Table 4-4

North American Projected Dollar Sales for Top Manufacturers of Body Shaping & Skin Tightening Device Platforms

194

Figure 4-2 North American Sales Growth of Body Shaping & Skin Tightening Platforms 195

Table 4-5

European Projected Dollar Sales for Top Manufacturers of Body Shaping & Skin Tightening Device Platforms

196

Figure 4-3 European Sales Growth of Body Shaping & Skin Tightening Platforms 197

Table 4-6

Asian Projected Dollar Sales for Top Manufacturers of Body Shaping & Skin Tightening device Platforms

198

Figure 4-4 Asian Sales Growth of Body Shaping & Skin Tightening Platforms 199

Table 4-7

Latin American Projected Dollar Sales for Top Manufacturers of Body Shaping & Skin Tightening Device Platforms

200

Figure 4-5 Latin American Sales Growth of Body Shaping & Skin Tightening Platforms 201

Figure 4-6 Dollar Sales of Body Shaping & Skin Tightening Device Platforms by Region 202

Table 4-8

Worldwide Projected Dollar Sales for Top Manufacturers of Body Shaping & Skin Tightening Device Disposables

203

Figure 4-7

Worldwide Dollar Sales of Body Shaping & Skin Tightening Device Disposables

204

Table 4-9

North American Projected Dollar Sales for Top Manufacturers of Body Shaping & Skin Tightening Device Disposables

205

Figure 4-8

North American Dollar Sales of Body Shaping & Skin Tightening Device Disposables

206

Table 4-10

European Projected Dollar Sales for Top Manufacturers of Body Shaping & Skin Tightening Device Disposables

207

Figure 4-9 European Dollar Sales of Body Shaping & Skin Tightening Device Disposables 208

Table 4-11

Asian Projected Dollar Sales for Top Manufacturers of Body Shaping & Skin Tightening Device Disposables

209

Figure 4-10 Asian Dollar Sales of Body Shaping & Skin Tightening Device Disposables 210

Table 4-12

Latin American Projected Dollar Sales for Top Manufacturers of Body Shaping & Skin Tightening Device Disposables

211

Figure 4-11

Latin American Dollar Sales of Body Shaping & Skin Tightening Device Disposables

212

Figure 4-12 Dollar Sales of Body Shaping & Skin Tightening Device Disposables by Region 213

Table 4-13 Worlwide Procedure Volume for Body Shaping & Skin Tightening 214

Figure 4-13 Worldwide Procedure Fees for Body Shaping & Skin Tightening 215

Figure 4-14 Worldwide Procedure Volume for Body Shaping & Skin Tightening by Region 216

Figure 4-15 Worldwide Procedure Fees for Body Shaping & Skin Tightening by Region 217

Figure 4-16 Average Number of Weekly Energy-Based Skin Tightening Treatments 218

Figure 4-17 Average Charge for Single Energy-Based Skin Tightening Treatment 219




Figure 4-18 Average Number of Weekly Energy-Based Body Shaping Treatments 220

Figure 4-19 Average Charge for Single Energy-Based Body Shaping Treatment 221

Table 4-14

Worldwide Market Shares of Body Shaping & Skin Tightening Platforms and Disposables

222

Figure 4-20 Change in Market Shares of Body Shaping & Skin Tightening Platforms 223

Table 5-1 Leading Neurotoxins 227

Figure 5-1 BOTOX Injection Points 231

Figure 5-2 BOTOX Injection Points for Lateral Canthal Lines 232

Table 5-2 Worldwide Projected Dollar Sales for Leading Neurotoxins 242

Figure 5-3 Worldwide Sales Growth of Neurotoxins 243

Table 5-3 North American Projected Dollar Sales for Leading Neurotoxins 244

Figure 5-4 North American Sales Growth of Neurotoxins 245

Table 5-4 European Projected Dollar Sales for Leading Neurotoxins 246

Figure 5-5 European Sales Growth of Neurotoxins 247

Table 5-5 Asian Projected Dollar Sales for Leading Neurotoxins 248

Figure 5-6 Asian Sales Growth of Neurotoxins 249

Table 5-6 Latin American Projected Dollar Sales for Leading Neurotoxins 250

Figure 5-7 Latin American Sales Growth of Neurotoxins 251

Figure 5-8 Dollar Sales Growth of Neurotoxins by Region 252

Table 5-7 Worldwide Procedure Volume for Neurotoxins 253

Figure 5-9 Worldwide Procedure Fees for Neurotoxins 254

Figure 5-10 Worldwide Procedure Volume for Neurotoxins by Region 255

Figure 5-11 Worldwide Procedure Fees for Neurotoxins by Region 256

Figure 5-12 Average Number of Weekly Neurotoxin Patients 257

Figure 5-13 Average Charge for Single Neurotoxin Injection (Single Tx Session) 258

Table 5-8 Worldwide Market Shares of Top Neurotoxin Suppliers 259

Figure 5-14 Change in Market Shares of Top Neurotoxin Suppliers 260

Table 6-1 Leading Dermal Fillers 265

Table 6-2 Characteristics of Selected Dermal Fillers 267

Table 6-3 Projected Worldwide Dollar Sales of Dermal Fillers for Top Suppliers 290




Figure 6-1 Worldwide Sales Growth of Dermal Fillers 291

Table 6-4 Projected North American Dollar Sales of Dermal Fillers for Top Suppliers 292

Figure 6-2 North American Sales Growth of Dermal Fillers 293

Table 6-5 Projected European Dollar Sales of Dermal Fillers for Top Suppliers 294

Figure 6-3 European Sales Growth of Dermal Fillers 295

Table 6-6 Projected Asian Dollar Sales of Dermal Fillers for Top Suppliers 296

Figure 6-4 Asian Sales Growth of Dermal Fillers 297

Table 6-7 Projected Latin American Dollar Sales of Dermal Fillers for Top Suppliers 298

Figure 6-5 Latin American Sales Growth of Dermal Fillers 299

Figure 6-6 Dollar Sales of Dermal Fillers by Region 300

Table 6-8 Worldwide Procedure Volume for Dermal Fillers 301

Figure 6-7 Worldwide Procedure Fees for Dermal Fillers 302

Figure 6-8 Worldwide Procedure Volume for Dermal Fillers by Region 303

Figure 6-9 Worldwide Procedure Fees for Dermal Fillers by Region 304

Figure 6-10 Average Number of Weekly Dermal Filler Patients 305

Figure 6-11 Average Charge for Single Dermal Filler Injection 306

Table 6-9 Market Shares of Top Dermal Filler Suppliers 307

Figure 6-12 Change in Market Shares of Top Dermal Filler Suppliers 308

Table 7-1 Leading Suppliers of Liposuction Equipment 311

Table 7-2

Projected Worldwide Dollar Sales for Leading Suppliers of Liposuction Equipment

314

Figure 7-1 Worldwide Sales Growth of Liposuction Equipment 315

Table 7-3

Projected North American Dollar Sales for Leading Suppliers of Liposuction Equipment

316

Figure 7-2 North American Sales Growth of Liposuction Equipment 317

Table 7-4

Projected European Dollar Sales for Leading Suppliers of Liposuction Equipment

318

Figure 7-3 European Sales Growth of Liposuction Equipment 319

Table 7-5 Projected Asian Dollar Sales for Leading Suppliers of Liposuction Equipment 320

Figure 7-4 Asian Sales Growth of Liposuction Equipment 321

Table 7-6

Projected Latin American Dollar Sales for Leading Suppliers of Liposuction Equipment

322

Figure 7-5 Latin American Sales Growth of Liposuction Equipment 323




Figure 7-6 Dollar Sales Growth of Liposuction Equipment by Region 324

Table 7-7 Worldwide Procedure Volume for Liposuction 325

Figure 7-7 Worldwide Procedure Fees for Liposuction 326

Figure 7-8 Worldwide Procedure Volume for Liposuction by Region 327

Figure 7-9 Worldwide Procedure Fees for Liposuction by Region 328

Table 7-8

Worldwide Market Shares for Leading Manufacturers of Liposuction Equipment

329

Figure 7-10

Change in Market Shares of Leading Manufacturers of Liposuction Equipment

330

Table 8-1 Leading Breast Implant Products 334

Table 8-2

Worldwide Projected Dollar Sales for Leading Manufacturers of Breast Implants

345

Figure 8-1 Worldwide Sales Growth of Breast Implants 346

Table 8-3

North American Projected Dollar Sales for Leading Manufacturers of Breast Implants

347

Figure 8-2 North American Sales Growth of Breast Implants 348

Table 8-4

European Projected Dollar Sales for Leading Manufacturers of Breast Implants

349

Figure 8-3 European Sales Growth of Breast Implants 350

Table 8-5 Asian Projected Dollar Sales for Leading Manufacturers of Breast Implants 351

Figure 8-4 Asian Sales Growth of Breast Implants 352

Table 8-6

Latin American Projected Dollar Sales for Leading Manufacturers of Breast Implants

353

Figure 8-5 Latin American Sales Growth of Breast Implants 354

Figure 8-6 Dollar Sales of Breast Implants by Region 355

Table 8-7 Worldwide Procedure Volume for Breast Implants 356

Figure 8-7 Worldwide Procedure Fees for Breast Implants 357

Figure 8-8 Worldwide Procedure Volume for Breast Implants by Region 358

Figure 8-9 Worldwide Procedure Fees for Breast Implants by Region 359

Table 8-8 Worldwide Market Shares of Top Breast Implant Manufacturers 360

Figure 8-10 Change in Market Shares of Top Breast Implant Manufacturers 361

Table 9-1 Comparison of Benefits: Cosmeceuticals vs. In-Office Treatments 366

Table 9-2 Top Cosmeceutical Ingredients 370

Table 9-3 Top Chemical Peel Suppliers 387

Table 9-4 Eyelash Enhancement Products 392




Table 9-5

Projected Worldwide Sales of Physician-Dispensed Topicals for Top Suppliers

437

Figure 9-1 Worldwide Sales Growth of Physician-Dispensed Topicals 438

Table 9-6

Projected North American Sales of Physician-Dispensed Topicals for Top Suppliers

438

Figure 9-2 North American Sales Growth of Physician-Dispensed Topicals 439

Table 9-7

Projected European Sales of Physician-Dispensed Topicals for Top Suppliers

440

Figure 9-3 European Sales Growth of Physician-Dispensed Topicals 441

Table 9-8 Projected Asian Sales of Physician-Dispensed Topicals for Top Suppliers 442

Figure 9-4 Asian Sales Growth of Physician-Dispensed Topicals 443

Table 9-9

Projected Latin American Sales of Physician-Dispensed Topicals for Top Suppliers

444

Figure 9-5 Latin American Sales Growth of Physician-Dispensed Topicals 445

Figure 9-6 Dollar Growth of Physician-Dispensed Topicals for Top Suppliers by Region 446

Figure 9-7 Do You Currently Sell Skincare Products from Your Practice? 447

Figure 9-8 If Yes, Approximately How Much Revenue Does this Generate Annually? 448

Table 9-10

Worldwide Market Shares of Leading Manufacturers of Physician-Dispensed Topicals

449

Figure 9-9

Change in Global Market Shares of Leading Manufacturers of Physician-Dispensed Topicals

450

Table 10-1 Worldwide Projected Dollar Sales for Emerging Products 464

Figure 10-1 Projected Worldwide Sales of Emerging Products for Top Suppliers 465

Table 11-1

Leading Technology-Based Home-Use Aesthetic Devices Available and Under Development

470

Figure 11-1 Market Shares of Top Home-Use Aesthetic Players by Retails Sales 491

Table 11-2 Projected Worldwide Retail Sales of Aesthetic Home-Use Devices 493

Figure 11-2 Worldwide Aesthetic Home-Use Device Retail Sales by Company 494

Table 11-3

Worldwide Projected Dollar Sales for Leading Aesthetic Home-Use Devices, by Region

495

Table 11-4

Worldwide Projected Retail Sales of Home-Use Aesthetic Devices, Disposables

496

Table 11-5

Worldwide Projected Retail Sales of Home-Use Aesthetic Devices and Disposables

497

Table 12-1 Total Worldwide Sales of Aesthetic Products 498

Figure 12-1 Worldwide Aesthetic Product Sales by Market Segment 499

Table 12-2 Total North American Sales of Aesthetic Products 500

Figure 12-2 North American Aesthetic Product Sales by Market Segment 501




Table 12-3 Total European Sales of Aesthetic Products 502

Figure 12-3 European Aesthetic Product Sales by Market Segment 503

Table 12-4 Total Asian Sales of Aesthetic Products 504

Figure 12-4 Asian Aesthetic Product Sales by Market Segment 505

Table 12-5 Total Latin American Sales of Aesthetic Products 506

Figure 12-5 Latin American Aesthetic Product Sales by Market Segment 507

Figure 12-6 Worldwide Aesthetic Product Sales by Region 508

Table 12-6 Procedure Volume Growth by Segment in Millions 509

Table 12-7 Procedure Volume Growth by Region in Millions 509

Table 12-8 Procedure Fee Growth by Segment in $ Billions 510

Table 12-9 Procedure Fee Growth by Region in $ Billions 510

Table 12-10 Total Sales of Leading Manufacturers 511

Table 12-11 Market Shares of Leading Manufacturers 512

Figure 12-7 Change in Market Shares of Leading Aesthetic Manufacturers 513

Figure 13-1 Number of Employees in Practice in 2015 515

Figure 13-2 Annual Practice Revenue in 2015 516

Figure 13-3 Average Weekly Aesthetic Patient Volume in 2015 517

Figure 13-4 Do You Expect to Expand Your Staff in 2016? 519

Figure 13-5 Expected Practice Revenue Change in 2016 520

Figure 13-6 Expected Practice Profit Margin Change in 2016 521

Figure 13-7 Did You Implement any Cost Reduction Measures in 2015? 522

Figure 13-8 If Yes, What Cost Reduction Measures did You Implement? 523

Figure 13-9 Do You Plan to Implement any Cost Reduction Measures in 2016? 524

Figure 13-10 If Yes, What Cost Reduction Measures do You Plan to Implement? 525

Figure 13-11 Expected Average Weekly Aesthetic Patient Volume Change in 2016 526

Figure 13-12 Did You Add any New Aesthetic Services in 2015? 527

Figure 13-13 If Yes, Which New Services did You Add? 528

Figure 13-14 Aesthetic Services that Generate the Most Revenue 529

Figure 13-15 Most Profitable Aesthetic Services 530

Figure 13-16 Do You Plan to Add Any New Aesthetic Services in 2016? 531




Figure 13-17 If Yes, What Services? 532

Figure 13-18 Do You Plan to Discount or Scale Back Any Aesthetic Services in 2016? 533

Figure 13-19 Did you Purcahse / Lease Any New Aesthetic Equipment in 2015? 534

Figure 13-20 If Yes, What Treatments Does This Equipment Perform? 535

Figure 13-21 Do You Plan to Purchase / Lease Any New Equipment in 2016? 536

Figure 13-22 If Yes, What Treatments Will This New Equipment Perform? 537

Figure 13-23 What Trends, If Any, Are You Noticing Among Your Patients? 538

Figure I-I Selected Facial Treatments Consumer Value Comparison 541

Figure I-II Selected Energy Devices Consumer Value Comparison 542

Figure I-III Cosmetic Surgical Consumer Value Comparison 543

Table I-I Facial Rejuvenation Treatment Comparison 545

Figure I-IV Results vs. Risk for Facial Treatments 546

Table I-II Physician vs. Non-Physician Usage of Aesthetic Procedures 549




i. Methodology

The Global Aesthetic Market XIV (GAM XIV) represents the fourteenth edition in Medical

Insight, Inc.’s Global Aesthetic Market series. This report was compiled from a wide variety of

public and proprietary sources. Information was cross-checked against other data, using Medical

Insight’s proprietary forecasting models, and synthesized into both qualitative and quantitative

analyses and projections, specifically covering medical aesthetic products and equipment;

products and equipment designed for therapeutic usage, even when they are produced by leading

aesthetic companies, are not included. Therefore, new devices for instance, such as the treatment

of onychomycosis are excluded.

Public sources that were utilized for this report include:

- articles in trade publications and medical journals;

- articles in consumer magazines and newspapers;

- company news releases, website information, marketing materials and financial filings;

- information from trade associations

Proprietary sources that were utilized include:

- Medical Insight’s extensive database of industry and product information;

- recent Medical Insight survey data;

- industry analyst reports;

- exclusive interviews with company executives, researchers, sales representatives,

physicians, patients, consultants and other industry experts

Additionally, feedback from Medical Insight product information is continually built back

into research products so that reports are updated with the most recent industry and market

information on an ongoing basis.




ii. New in June 2016

GAM XIV offers an in-depth analysis of the competitive positions of key players in all segments

with details obtained from recent interviews.

In addition to the latest industry news and updated market forecasts, which take into account

recent technology, product, company, regulatory and other developments, GAM XIII also contains:

- Extension of sales forecasts from 2015 to 2020;

- comparison of current forecasts to GAM XIII forecasts and discussion of changes;

- links to online videos for selected technologies and treatments;

- analysis of political, economic and other factors impacting the aesthetic market,

particularly in the U.S. and Europe




Section

Executive Summary 1

In 2015, total sales of professional aesthetic products covered in this report, including

disposable components, exceeded $7.6 billion. Through 2020, they will expand by 11.0% per year to

$12.8 billion. This is lower than the compound annual growth of 11.8% predicted in GAM XIII, released

in early 2015 as forecasts were adjusted to reflect the ongoing global economic uncertainty. Growth

will be driven by significant increases in the body shaping / skin tightening segment along with

continued expansion of neurotoxins and dermal fillers. The energy-based devices and physician-

dispensed topicals markets will also experience reasonable annual gains of 6.5% and 7.5%,

respectively, as demand for these products results in increased sales.

In 2015, the leading companies profiled in this report accounted for total professional aesthetic

product sales of about $5.5 billion, representing approximately 73% of the total market. Their sales

will rise by 11.5% per year to reach more than $9.5 billion in 2020.

In 2015, total global procedure volume reached 59 million treatments with compound annual

growth of 6.3% anticipated through 2020. Procedure volume growth will be greatest in the body

shaping / skin tightening, neurotoxin and dermal filler sectors. On a global basis, procedure volume

will grow most strongly in Asia and Latin America. In 2015, total global procedure fees were about $26

billion, with compound annual growth predicted of 5.4% through 2020. As with procedure volume,

procedure fee growth will be greatest in the body shaping / skin tightening, neurotoxin and dermal filler

sectors. On a global basis, procedure fees will grow most strongly in Asia and Latin America.

The aesthetic market was notable in 2015 and 2016 for the continuing consolidation of

companies and changing regulatory environment with the U.S. Department of Treasury curbing U.S.

company inversions to domiciles with more favorable tax laws. Most notable was the successful

acquisition and inversion of Allergan by Actavis (the consolidated company is named Allergan), and

the subsequent potential merger with Pfizer that was called off after the U.S. Treasury intervened.

The aesthetic market continues to be of interest for both pharma and consumer companies

wanting to diversify into a sector that is showing strong growth, is highly profitable and has

characteristics of both a consumer packaged goods and traditional pharmaceutical model. This is

exemplified by Almirall, a Spanish based pharma company that has entered the aesthetic market by




acquiring Thermi (energy-based body shaping and skin tightening) and also partnering with Suneva

(dermal filler). Also notable is the topical skincare market where companies such as Unilever, which

acquired various skincare brands in 2015, namely REN, Murad, Dermalogica and Kate Somerville

Skincare to add to their portfolio of other skincare brands. Unilever Ventures also has a joint venture

with Syneron, namely iLuminage Beauty, which is developing products for the home-use market.

The acquisition of technologies continues such as with the purchase of both Kythera and

Anterios by Allergan, and the forming of new beneficial collaborations such as Galderma and ZELTIQ.

The acquisition of Kythera gave Allergan, Kybella which is the first-of-its-kind body sculpting injectable

that treats submental fat, while Anterios gave Allergan a new platform to deliver botulinum toxins

topically for indications such as crow's feet lines and hyperhidrosis. Galderma and ZELTIQ are

collaborating to promote their respective injectable portfolio and CoolScupting brands and connecting

these through ASPIRE, a patient and physician loyalty program.

Energy-based device companies are also improving technologies and introducing new

treatment modalities that are expanding indications. These include new body sculpting devices such

as Sculpsure from Cynosure, which is the first FDA approved laser treatment for non-invasive lipolysis

of the flanks and abdomen and the introduction of a number of new devices for feminine rejuvenation

/ women’s health, which potentially could become a large market segment in itself with brands such

as Viveve from Viveve, Inc., MonaLisa Touch from DEKA / Cynosure and ThermiVa from Thermi.

The aesthetic market is also being enhanced with the introduction of new business models

such as service companies like RegimenMD that has introduced a new distribution channel for

professional skincare products designed to help physicians maintain a professional relationship with

their patients by supplying products directly to the physician’s patients. To date 20 major

manufacturers are partnering with RegimenMD including SkinMedica, NeoStrata, Jan Marini,

Skinceuticals, MDRejuvena and Nuvesse Skin Therapies.

Along with these various successes have been challenges as exhibited with the breast implant

market where Silimed (distributed by Sientra in the U.S.) withdrew its implants from the market to

resolve manufacturing issues. This was further compounded with a fire that will impact the supply of

Silimed implants globally for an unspecified time while production is restored.




0.0

200.0

400.0

600.0

800.0

1,000.0

1,200.0

1,400.0

1,600.0

1,800.0

2,000.0

2015 2016 2017 2018 2019 2020

Rev

en

ue $

MM

s

Allergan Medical Alphaeon/ Daewoong Daewoong

Galderma Lanzhou Institute MedyTox

Merz Other

Figure 5-3 Worldwide Sales Growth of Neurotoxins,

2015 – 2020


global aesthetic market study - medical insight inc · global aesthetic market xiv june 2016...

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