Fast Facts About Cruciferous Plus™

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Fast Facts AboutCruciferous Plus™Cruciferous vegetables — the family that includes broccoli, cauliflower, Brussels sprouts, and collardgreens — contain special phytonutrients that are not found in any other foods and may lower the riskof certain cancers, especially breast, prostate, and digestive tract cancers. The American CancerSociety recommends eating one serving of cruciferous vegetables every day, but most of us only eatone serving a week. Each Cruciferous Plus tablet provides the phytonutrient value of an optimalserving of a wide variety of cruciferous vegetables.

Why Cruciferous Vegetables?• Research has shown a link between a high

consumption of cruciferous vegetables and alow risk for developing certain cancers(breast, prostate, lining of the uterus, lung,colon and other digestive tract cancers).

• Cruciferous vegetables contain uniquephytonutrients (plant nutrients) that are notfound in any other foods, but are essential forgood health.

• Cruciferous vegetables contain substancesshown in research studies to help strengthenthe body’s defenses.

• The National Cancer Institute, the AmericanCancer Society, and the National ResearchCouncil all recommend consuming oneserving of cruciferous vegetables each day.

“The National Cancer Instituterecommends eating one serve ofcruciferous vegetables every day,but most of us don’t eat any at all.”

Why GNLD Cruciferous Plus™?• Broad-spectrum cruciferous vegetable

supplementation. Each tablet provides thephytonutrient value of one optimal serving of awide variety of cruciferous vegetables.

• GNLD’s exclusive cruciferous blendcontains broccoli, radish, kale, black mustard,brown mustard and watercress.

• Cruciferous Plus supplies other beneficialphytonutrients — limonene from oranges,chalcones from licorice root, and isoflavonesfrom soybeans — which research has showncan help maintain healthy cellular growth.

• Contains sulforaphane , an importantphytonutrient in cruciferous vegetables thathelps neutralise carcinogens (cancer-causing agents) and other toxins.Research shows that sulforaphane can helpprotect against the development ofhormonally-mediated cancers.

• Whole-food ingredients provide severalimportant phytonutrients with health benefits(neutralising toxins, lowering cholesterol,boosting immunity, influencing metabolism,reducing menopausal symptoms) in additionto regulating the growth of cells.

• 100% Natural. Cruciferous Plus™ contains noartificial colours, flavours, preservatives orsweeteners.

• Convenient serving - just one more way tohelp you meet the recommendations of theNational Cancer Institute, the AmericanCancer Society and the National ResearchCouncil to consume one serving ofcruciferous vegetables every day.

We should eat one serving of cruciferous vegetablesevery day, according to the National CancerInstitute, the American Cancer Society and theNational Research Council. On average we only eathalf a serve every day. In fact, on any day, only 25%of Australians eat cruciferous vegetables1.

Fast Facts About Cruciferous Plus™

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PRODUCT FEATURES

• Broad-spectrum phytonutrients. Eachtablet provides the phytonutrient value ofan optimal serving of a wide variety ofcruciferous vegetables.

• Whole-food ingredients. Containsbroccoli, radish, kale, black mustard,brown mustard and watercress.

• Other important phytonutrients -limonene from oranges, chalcones fromlicorice root and isoflavones fromsoybeans.

• Sulforaphane, a key protectivephytonutrient, especially abundant inbroccoli, which helps neutralise cancer-causing agents and other toxins.

• 100% Natural. Contains no artificialcolours, flavours, preservatives orsweeteners.

• Convenient serving - just one more wayto help you meet recommendations toconsume one serving of cruciferousvegetables per day.

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How much we actually eat* How much we should eat†

*According to the United States Department of Agriculture.

† According to the National Cancer Institute, The American Cancer Society,And the National Research Council.

New Zealand product illustrated

Australian product illustrated

A Mountain Of Research SupportsThe Benefits Of CruciferousVegetables

Scientists often disagree amongst themselves,debating the latest theories in journal articles and at

research conferences. But fruits andvegetables seem to be one areawhere the research is socompelling and convincing that itwould be hard to find anyonewilling to take the “con” side ofthe debate. Thousands ofscientific studies documentthe health benefits of dietsrich in fruits and vegetables,and hundreds l ink thesediets with lower risks ofdeveloping cancer. Amongthis mountain of research,some of the strongestevidence correlates lower

cancer rates with increasedconsumption of cruciferous vegetables, named fortheir cross-shaped flower petals. Members of thispungent family include:

• bok choy (Chinese cabbage)• broccoflower (a newcomer that looks like

green cauliflower)• broccoli• Brussels sprouts• cabbage• calabrese (sprouting broccoli)• cauliflower• collard greens• horseradish• kale• kohlrabi• mustard• mustard greens• radish• rutabaga• turnips• turnip greens• watercress

The first study reporting the benefits of cruciferousvegetables was published in 1978. Since then, thebeneficial properties of cruciferous vegetables havebeen so well documented that the National CancerInstitute, the American Cancer Society and theNational Research Council all recommendconsuming at least one serving of cruciferousvegetables per day. Now a unique product from

GNLD, Cruciferous Plus™ supplies bioactivephytonutrients from cruciferous vegetables andother plants (oranges, licorice root, soybeans)shown to help protect health.

The Best Offense is good defence.What’s in cruciferous vegetables that helps

protect your health? Besides having lots ofvitamins, minerals, and fibre, cruciferous vegetablesare chock-full of other vital plant nutrients calledphytonutrients. Some of the first healthfulphytonutrients to be identified by scientists werethe carotenoids and flavonoids, families of colourfulpigments from fruits and vegetables that helpprotect the lipid- and water-soluble portions ofcells, respectively, from oxidative damage.

The phytonutrients in cruciferous vegetables,however, help protect your cells in different ways.Research has shown that the special protectionafforded by cruciferous phytonutrients can lessenour risk of developing what scientists call“hormonally mediated” cancers (breast, prostate,lining of the uterus), as well as other cancers (lung,colon and other digestive tract cancers). Howcruciferous vegetables and other plants can helpprevent cancer is not yet fully understood, but it islikely that they:• boost production of enzymes that detoxify

cancer-causing agents (carcinogens) and flushthem out of the body.3,4

• prevent the conversion of “good” oestrogen (ahormone correlated with a lower risk for breastcancer) to “bad” oestrogen (correlated with ahigher risk).5,6

• defend cells from infiltration of “bad” oestrogenby blocking its entry sites on the cellmembrane.7,8

• inhibit the formation of carcinogens by preventingactivation of their precursors (toxins andmutagens).3,4

In addition to reducing cancer risks, compoundsin cruciferous vegetables have been shown to:

• neutralise toxins • lower cholesterol• regulate the immune system• influence metabolism

The Cruciferous Story

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The Cruciferous Story

Cruciferous Plus’s Risk-ReductionTeam

We wanted to create the most complete,technologically advanced product on the market toharness the healthful properties of cruciferousvegetables. To achieve this goal we first examinedalmost two decades of research correlatingcrucifers with reduced cancer risks and identifiedkey protector nutrients. Then, in formulating ourexclusive Cruciferous Plus blend, we used all-natural foods as sources of these vitalphytonutrients, derived from a wide variety ofcruciferous vegetables to ensure broad-spectrumsupplementation:

• broccoli• radish• kale• black mustard• brown mustard• watercress

These cruciferous vegetables contain two mainphytonutrients that science has shown may loweryour risk of developing cancer:• Isothiocyanates. One potent member of this

family of protector nutrients is sulforaphane, acomponent of broccoli and other crucifers thathas been shown to inhibit tumours of the lung,oesophagus, stomach, small intestine, colon,breast, liver, and bladder in rats and mice.Sulforaphane can prevent chemicals frombecoming active carcinogens in the first place,stimulate enzymes that detoxify them, block theirinteraction with DNA, and facil itate theirexcretion. Its potential for preventing cancer isthe subject of current human clinical trials.3

• Indole carbinols. These compounds encourageoestrogen to follow a metabolic pathway that isassociated with a reduced risk of breast cancer.Indole carbinols also can defuse cancer-promoting oestrogen byproducts and facilitatetheir excretion.5,6

Cruciferous Plus also contains antioxidants fromoranges, licorice root, and soybeans that helpprotect your cells in different ways:

• Terpenes. D-Limonene, a terpene (plant oil) incitrus fruits, can boost levels of enzymes thatbreak down carcinogens, stimulate cancer-killingimmune cells, and inhibit oncogenes (genescapable of causing cancer). It has been shown toinhibit breast cancer at all stages in animalstudies and has even been shown to causeregression of breast cancer in rats.4,9 Human trialsare now in progress in the United Kingdom andthe United States to investigate its ability toprevent breast cancer.

• Chalcones. A sweet substance in licorice root,chalcones have been shown to prevent the

formation of a byproduct of testosterone thatspurs the growth of prostate cancer. Relatives ofantioxidant flavonoids, they can also prevent theDNA damage that often precedes cancer.10

• Isoflavones. Research has shown thatisoflavones such as genistein in soybeans caninhibit cancer by hindering the growth of thecapillaries that supply tumours, blocking the entryof oestrogen into cells, and deterring theproliferation of cancer cells. Genistein is currentlyunder investigation as an agent to prevent cancerin humans.11

“On any given day, 75% of AustraliansDO NOT eat cruciferous vegetables.”

Consume Six A Day And MakeOne Cruciferous

Population studies show that people who consumethe most fruits and vegetables have better healththan those who eat the least.2

As many as 35% of all cancer deaths may beprevented simply by eating right, according to theAmerican Cancer Society. That organisation, theNational Cancer Institute (United States), NationalResearch Council (United States), and the CSIRO(Australia) all recommend consuming at least fiveservings of fruits and vegetables per day, includingone of cruciferous vegetables, as a means ofpreventing cancer.

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Fruit And Vegetable Consumption:Almost Everyone Falls Short

Yet people worldwide fall profoundly short ofmeeting the six-serving recommendations.Research shows that only a small proportion of thepopulation consumes the recommended minimumof six servings of fruit and vegetables per day. Theaverage Australian is missing one third ofrecommended fruit and vegetables. More than onethird of Australians eat NO fruit on any day and 10%of Australians eat NO vegetables on any given day.1

Even if you think you’re eating enough of the rightstuff, you could be fooling yourself. A studycommissioned by the United Fresh Fruit andVegetable Association revealed that consumersoverestimated the amounts of fruit and vegetablesthey ate by 33%. Examination of food diaries from2000 households showed that study participantsactually ate 13% fewer vegetable and 56% fruitservings than they reported.

The Cruciferous Vegetable GapCruciferous vegetables are particularly unpopular;

75% of Australians DO NOT eat cruciferousvegetables on any given day, with intake averagingout to half a serve daily (instead of 1 per day asrecommended).1 The Japanese, who enjoy some ofthe world’s lowest cancer rates, especially forhormonally mediated cancers, meet the cruciferouschallenge by eating eight servings per week.12 Thebottom line is that most of the world’s people, evenin developed nations, aren’t eating anywhere nearthe amount of crucifers recommended by publichealth authorities.

In addition, people aren’t getting enough of otherbeneficial phytonutrients. Non-Asian diets frequentlymiss out on the benefits of soy products, andlicorice root, which provides chalcones, is hardly adietary staple. D-Limonene is removed from orangesand lemons during juice production to curb rancidityproblems. The result? We’re not getting the fullprotection that Mother Nature can offer.

Cruciferous Plus™ Bridges The GapWhile eating a serving of Brussels sprouts,

cabbage or broccoli each day is easier said thandone, getting the phytonutrients you need is noweasier than ever. In a convenient tablet, GNLD’sCruciferous Plus™ provides the nutrient density anddiversity of phytonutrients found in one optimalserving of a combination of cruciferous vegetables.Based in Nature and Backed by Science,Cruciferous Plus™ offers an excellent means ofbridging dietary gaps and supplying uniquephytonutrients.

References[1] Department of Community Services & Health.

National Dietary Survey of adults: 1983. No 2 FoodsConsumed. Australian Government PublishingService. Canberra: 1987.

[2] Block, G., Patterson, B. and Subar, A. Fruit,Vegetables and Cancer Prevention: A Review of theEpidemiological Evidence. Nutrition and Cancer18:1-29, 1992.

[3] Zhang, Y., and Talalay, P. Anti-carcinogenicActivities of Organic Isothiocyanates: Chemistry &Mechanisms. Cancer Research. Supplement54:1976-1981, 1994.

[4] Crowell, P.L., et al. Chemoprevention ofmammary carcinogenesis by hydroxylatedderivatives of d-limonene. Carcinogenesis 13(7):1261-1264, 1992.

[5] Michnovicz, J.J. and Bradlow, H.L. Induction ofEstradiol Metabolism by Dietary Indole-3-Carbinol inHumans. J. Natl. Cancer Inst. 82:947-949, 1990.

[6] Niwa, T., Swaneck, G., Bradlow, H.L. Alterationsin estradiol metabolism in MCF-7 cells induced bytreatment with indole-3-carbinol and relatedcompounds. Steroids 59(9): 523-7, 1994.

[7] Collins, B.M., McLachlan, J.A. and Arnold, S.F.The estrogenic & antiestrogenic activities ofphytochemicals with the human estrogen receptor inyeast. Steroids 62(4): 365-372, 1997.

[8] Stoll, B.A., Eating to beat breast cancer:potential role for soy supplements. Am. Oncol. 8(3):223-5, 1997.

[9] Gould, M.N. Prevention & Therapy of MammaryCancer by Monoterpenes. J. Cell. Biochem.Supplement 22:139-144, 1995

[10] Shibata, S. Anti-tumorigenic Chalcones. StemCells 12:44-52, 1994.

[11] Barnes, S., Peterson, G., Grubbs, C. andSetchell, K. Potential role of dietary isoflavones inthe prevention of cancer: In Diet & Cancer: Markers,Prevention & Treatment. Jacobs, M.M., ed. PlenumPress, New York, pp 135-147, 1994.

[12] Fenwick, G.R., Heaney, R.K. and Mullin, W.J.Glucosinolates and Their Breakdown Products inFood and Food Plants. CRC Critical Reviews inFood Science and Nutrition 18:123-201, 1983.

The Cruciferous Story

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