gujq;fs; - e-thaksalawa · 2019. 3. 26. · juk; 12, 13 njhfg;g : jpukjp a. jtuq;rpj;;, capupay;...
TRANSCRIPT
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Gujq;fs;
capupay;
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juk; 12, 13
njhFg;G : jpUkjp A. jtuQ;rpj;;, capupay; Mrpupau; (ah/aho;g;ghzk; ,e;Jf; fy;Yhup)
fzpdp tbtikg;G : jpU.r.uhjhutp j.njh.njh Mrpupau; (kd;/jiykd;dhH gpaH m.j.f. ghlrhiy> kd;dhH.)
Gujq;fs;
mkpNdh mkpyq;fshyhdit
20 NtWgl;l tifahd mkpNdh mkpyq;fs; Gujq;fspd; cUthf;fspy; gq;F tfpf;fpd;wd.
C,H,O,N kw;Wk; S %yfr; NrHf;ifahff; fhzg;gLk;.
mkpNdh mkpyf; fl;likg;gpy; kj;jpapy; cs;s fhgd; rkr;rPuw;wJ. tpjptpyf;F– glycine
mkpNdh mkpyj;jpd; nghJthd fl;likg;G
xt;nthU mkpNdh mkpyKk; xU Kidapy; mikNdh (NH2) $l;lj;ijAk; kW Kidapy;
fhnghl;iry; (COOH) $l;lj;ijAk; nfhz;bUg;gJld; H mZ kw;Wk; NtWgl;l $l;lq;fisf; Fwpf;Fk; R vDk; FwpaPl;bidAk; jkJ nghJf;fl;likg;gpy; nfhz;bUf;Fk;
Glycine mkpNdh mkpyj;jpy; R=H
R $l;lk; gf;fr; rq;fpyp vdTk; miof;fg;gLk;
Vida $l;lq;fs; ahTk; KJnfYk;G (back bone) vdTk; miof;fg;gLk; mjhtJ NH2,
COOH ,H $l;lq;fs; mkpNdh mkpyk; xd;wpdJ KJnfYk;ghff; fUjg;gLfpd;wd.
mkpNdh mkpyq;fs; xd;Wf;F Nkw;gl;l mikNdh $l;lq;fs;> kw;Wk; fhnghl;iry; $l;lq;fis nfhz;bUf;fyhk;
R my;yJ gf;fr; rq;fpyp nfhz;Ls;s $Wfspd; mbg;gilapy; mkpNdh mkpyq;fs; tifg;gLj;jg;gLfpd;wd.
mikd; $l;lk;
fhnghl;iry; mkpyf;$l;lk;
rkr;rPuw;w fhgd; α fhgd;
R=CH3/H/
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juk; 12, 13
njhFg;G : jpUkjp A. jtuQ;rpj;;, capupay; Mrpupau; (ah/aho;g;ghzk; ,e;Jf; fy;Yhup)
fzpdp tbtikg;G : jpU.r.uhjhutp j.njh.njh Mrpupau; (kd;/jiykd;dhH gpaH m.j.f. ghlrhiy> kd;dhH.)
Kidtw;w mkpNdh mkpyq;fs;
mkpNdh mkpyj;jpy; fhnghl;iry; kw;Wk; mikNdh $l;lq;fs; rk vz;zpf;ifapy; fhzg;gLk;
gf;fr; rq;fpyp (R) Kidtw;wjhf fhzg;gLk;
gf;fr; rq;fpyp ePH ehl;lkw;wJ
Eg- 01.Alanine
02.Valine
03.Leucine
04.Methionine
(Valine)
gf;fr; rq;fpyp Kidthf;fKs;sJ
,jd; gf;fr; rq;fpyp ePH ehl;lKs;sJ
Eg- 01.Serine
02.Threonine
03.Glutamine
04.Tyrosine
(Glutamine)
Vw;wkw;w KidTs;s mkpNdh mkpyq;fs;
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juk; 12, 13
njhFg;G : jpUkjp A. jtuQ;rpj;;, capupay; Mrpupau; (ah/aho;g;ghzk; ,e;Jf; fy;Yhup)
fzpdp tbtikg;G : jpU.r.uhjhutp j.njh.njh Mrpupau; (kd;/jiykd;dhH gpaH m.j.f. ghlrhiy> kd;dhH.)
kpd;Ndw;wk; nfhz;l gf;fr; rq;fpyp
,q;F gf;fr; rq;fpyp vjpNuw;wk; nfhz;ljhff; fhzg;gLk;
Eg- 01.Aspartic acid
02.Glutamic acid
03.Lysine
04.Arginine
05.Histidine
(Glutamic)
20 tifahd mkpNdh mkpyq;fisg; gaz;gLj;jp fyq;fs; 1000 ,w;Fk; Nkw;gl;l Gujq;fis cUthf;fpf;nfhs;fpd;wd
gf;fr; rq;fpypfspd; ngsjPf> ,urhaz ,ay;Gfspd; mbg;gilapy; Fwpj;j mkpNdh mkpyq;fs; jkf;Fwpa jw;rpwg;ghd ,ay;Gfisf; nfhz;bUf;Fk; ,j;jd;ik gy;ngg;iul; rq;fpypapy; mkpNdh mkpyj;jpd; njhopw;ghl;Lg; gq;fspg;gpy; ghjpg;ig Vw;gLj;Jk;
mkpNdh mkpyj;jpy; fhzg;gLk;
mikNdh $l;lk;- fhu / %y; ,ay;igAk;
fhnghl;iry; $l;lk;-mkpy ,ay;igAk; fhz;gpf;Fk;
,jdhy; mkpNdh mkpyq;fs;
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juk; 12, 13
njhFg;G : jpUkjp A. jtuQ;rpj;;, capupay; Mrpupau; (ah/aho;g;ghzk; ,e;Jf; fy;Yhup)
fzpdp tbtikg;G : jpU.r.uhjhutp j.njh.njh Mrpupau; (kd;/jiykd;dhH gpaH m.j.f. ghlrhiy> kd;dhH.)
Nkyjpff;Fwpg;G
ePupy; fiuf;fg;gLk; NghJ mkpy> fhu ,ay;gpidf; fhz;gpf;Fk; ePHf;fiury; xd;wpDs;
Zwitter ion / Dipolar ion epiyapy; fhzg;gLk;
fiury; Nkyjpfkhf mkpyj;jd;ikahFk;NghJ
fiury; Nkyjpfkhf fhuj;jd;ikahFk;
+H+ - H
+
,t;tpay;G fhuzkhf mkpNdh mkpyq;fs; clypy; jhq;fw;fiuryhf njhopw;gl;L PH
rPuhf;fypy; cjTfpd;wd
kdpjdpy; Fwpj;j tPr;rpDs; FUjp> kw;Wk; tpyq;Ffspy; clw;jputq;fspy; PH khw;wj;ij jhq;Fk; njhopiyr; nra;fpd;wd
Peptide (ngg;iul;;) gpizg;G cUthjy;
,uz;L mkpNdh mkpyq;fspilNa xLf;fw;jhf;fj;jpd; %yk; ePH %yf;$W xd;W mfw;wg;gLtjd; tpisthy; cUthFk; gpizg;G ngg;iul; gpizg;G vdg;gLk;
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juk; 12, 13
njhFg;G : jpUkjp A. jtuQ;rpj;;, capupay; Mrpupau; (ah/aho;g;ghzk; ,e;Jf; fy;Yhup)
fzpdp tbtikg;G : jpU.r.uhjhutp j.njh.njh Mrpupau; (kd;/jiykd;dhH gpaH m.j.f. ghlrhiy> kd;dhH.)
Gujq;fs; xt;nthd;Wk; xd;W my;yJ mjw;F Nkw;gl;l gy;ngg;iul; rq;fpypfshy; Mf;fg;gl;lit. gy;ngg;iul; rq;fpyp xt;nthd;Wk; mkpNdh mkpyq;fspd; NrHf;ifahyhdJ
mbg;gilahf 4 NtWgl;l Gujf; fl;likg;Gfs; fhzg;gLfpd;wd. ,it mtw;wpdJ njhopw;ghl;by; gpujhd gq;fspg;ig toq;Ffpd;wd.
NtWgl;l Gujf; fl;likg;Gfs;
Kjyhd fl;likg;G
Jizahd fl;likg;G
Gilahd fl;likg;G
Gilr;rpiw / ehw;Gilf; fl;likg;G
Kjyhd fl;likg;G (Primary Structure)
jdpj;Jtkhd njhlnuhOq;Fila> Neupa> jhdpnahU gy;ngg;iul; rq;fpyp (,q;F mkpNdh mkpyq;fs; Neupa xOq;fpy; xOq;Fg;gLj;jg;gl;bUf;Fk;)
mkpNdh mkpyq;fspd; vz;zpf;ifAk; mtw;wpd; tiffspd; jdpj;Jtkhd njhlnuhOq;Fk; ,q;F mtjdpf;fggLk;.
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juk; 12, 13
njhFg;G : jpUkjp A. jtuQ;rpj;;, capupay; Mrpupau; (ah/aho;g;ghzk; ,e;Jf; fy;Yhup)
fzpdp tbtikg;G : jpU.r.uhjhutp j.njh.njh Mrpupau; (kd;/jiykd;dhH gpaH m.j.f. ghlrhiy> kd;dhH.)
Jizahd fl;likg;G
Kjyhd fl;likg;Gila jdpnahU gy;ngg;iul; rq;fpyp RUsiltjhy; kw;Wk; kbg;giltjhYk; cUthf;fg;gLk; fl;likg;ghFk;
,J ,Utifg;gLk;
RUsp mikg;G α
kbg;Gj;jhs; mikg;G β
,q;F %yf;$w;W Ijurd; gpizg;Gfs;> xl;rprd; kw;Wk; Ijurd; mZf;fSf;F ,ilNa Vw;gLj;jg;gLfpd;wd
mjhtJ xU mkpNdh mkpyj;jpd; fhgidy; $l;lj;jpYs;s xl;rprd; mZtpw;Fk;> kw;wa mkpNdh mkpyj;jpd; iejurd; mZtpy; ,ize;Js;s IjurDf;Fk; ,ilNa Ijurd; gpizg;G cUthFk; ,q;F Ijurd; gpizg;Gf;fs; xOq;fhd ,ilntspfspy; cUthFk; (4 mkpNdh mkpyq;fis mLj;J) (xU mkpNdh mkpyj;jpd; N-H
$l;lk; kw;wa mkpNdh mkpyj;jpd; C=O $l;lk;)
cjhuzk; - nfuhw;wpd;
,q;F jdpnahU gy;ngg;iul; rq;fpyp jl cUtpy; tUk;NghJ rkhe;jukhf my;yJ vjpH rkhe;jukhf mikAk; gFjpfSf;F ,ilapy; fhgd; mZtpy;,ize;Js;s xl;rprd; mZtpw;Fk; iejurd; mZtpy; ,ize;Js;s Ijurd; mZtpw;Fk; ,ilapy; (%yf;$w;W) Ijurd; gpizg;G Vw;gLj;jg;gLk;
cjhuzk; - gl;Lg;Gujk;
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juk; 12, 13
njhFg;G : jpUkjp A. jtuQ;rpj;;, capupay; Mrpupau; (ah/aho;g;ghzk; ,e;Jf; fy;Yhup)
fzpdp tbtikg;G : jpU.r.uhjhutp j.njh.njh Mrpupau; (kd;/jiykd;dhH gpaH m.j.f. ghlrhiy> kd;dhH.)
Gilahd fl;likg;G
jdpnahU Jizahd gy;ngg;iul;L rq;fpyp NkYk; mjpfstpy; tisjy; kw;Wk; kbg;giljYf;F cl;gLk;NghJ jpUk;gy; mile;J neUf;fkhd Nfhs tbtj;ij cUthf;fp Kg;gupkhzf; fl;likg;igg; ngWk; epiyapy; Gilahd fl;likg;G cUthf;fg;gLfpd;wJ.
Kg;gupkhzf; fl;likg;ghdJ gf;fr; rq;fpypapy; cs;s mZf;fSf;fpilNa Vw;gLj;jg;gLk; ehd;F NtWgl;l gpizg;Gfshy; cWjpg;gLj;jg;gLfpd;wJ
01. Ijurd; gpizg;G
02. ,U fe;jf gpizg;G
03. mad; gpizg;G
04. te;jHthy; (Vander Waals) gpizg;Gf;fs; / ePH ehl;lkw;w ,ilj;jhf;fk;.
cjhuzk; - ngUk;ghyhd nehjpaq;fs;> kNahFNshgpd;> my;Gkpd;
ehw;Gilf; fl;likg;G
,uz;L my;yJ mjw;F Nkw;gl;l gy;ngg;iul;L rq;fpypfs; jpuz;L cUthFk; fl;likg;G
,jpYs;s xt;nthU gy;ngg;iul;L rq;fpypAk; Guj cg myF (Protein Sub Units) vdg;gLk;. ,r; rq;fpypfs; xd;Wld; xd;W %yf;$W mf kw;Wk; %yf;$w;W ,il gpizg;Gfshy; gpizf;fg;gl;bUf;Fk;.
cjhuzk; - nfhyh[d;
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juk; 12, 13
njhFg;G : jpUkjp A. jtuQ;rpj;;, capupay; Mrpupau; (ah/aho;g;ghzk; ,e;Jf; fy;Yhup)
fzpdp tbtikg;G : jpU.r.uhjhutp j.njh.njh Mrpupau; (kd;/jiykd;dhH gpaH m.j.f. ghlrhiy> kd;dhH.)
Gujq;fspd; fl;likg;Gf;fs;
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juk; 12, 13
njhFg;G : jpUkjp A. jtuQ;rpj;;, capupay; Mrpupau; (ah/aho;g;ghzk; ,e;Jf; fy;Yhup)
fzpdp tbtikg;G : jpU.r.uhjhutp j.njh.njh Mrpupau; (kd;/jiykd;dhH gpaH m.j.f. ghlrhiy> kd;dhH.)
,jpy; 3 xj;j RUspAUthd gy;ngg;iul; rq;fpypfs; (α helix)
xl;rprd; ,izAk; Gujk;
,q;F 4 polypeptide rq;fpypfs; fhzg;gLfpd;wd.
2 rq;fpypfs; α tif
2 rq;fpypfs; β tif
xt;nthU rq;fpypAk; Gujkw;w gFjpiaAk; nfhz;bUf;Fk; ,J (Haem) gFjp vdg;gLk; ,Uk;igf; nfhz;lJ.
ehHg;Gujk;
Collagen
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juk; 12, 13
njhFg;G : jpUkjp A. jtuQ;rpj;;, capupay; Mrpupau; (ah/aho;g;ghzk; ,e;Jf; fy;Yhup)
fzpdp tbtikg;G : jpU.r.uhjhutp j.njh.njh Mrpupau; (kd;/jiykd;dhH gpaH m.j.f. ghlrhiy> kd;dhH.)
Gujq;fspd; mikg;gopjy;
Denaturation of protein
Guj %yf;$W xd;wpy; fhzg;gLk; typik Fiwe;j ,urhazg; gpizg;GfSk; kw;Wk;
mtw;Wf;fpilNaahd ,ilj;jhf;fq;fSk; nraypoe;J Nghtjhy; GujkhdJ jdJ
jdpj;Jtkhd ,urhaz Kg;gupkhd fl;likg;ig ,oj;jy; - mikg;gopjy; vdg;gLk;.
mikg;gopjiy Vw;gLj;Jk; fhuzpfs;
caH ntg;gepiyAk; caH fjpupaf;fr; rf;jpAk;
typikahd mkpyq;fs;> td; fhuq;fs; kw;Wk; kpif cg;Gr; nrupTs;s fiury;fs;
ghu cNyhfq;fs;
Nrjdf; fiug;ghd;fs; kw;Wk; ryitg; nghUl;fs; Nghd;wtw;why; gpizg;Gf;fs; ePf;fg;glyhk;
Note - mkpNdh mkpyq;fspd; njhlnuhOq;Nf Gujj;jpd; tbtj;ij jPHkhdpf;Fk;. vdNt
Gujj;jpd; Kjyhd fl;likg;Ng Gujj;jpd; tbtj;ij epHzapf;fpd;wJ. Kjyhd fl;likg;gpy;
xOq;FgLj;jg;gLk; mkpNdh mkpyq;fspd; xOq;FKiwf;Nfw;gNt Gujj;jpy; Ijurd;> ,U
ry;igl;L> kw;Wk; eype;j gpizg;Gf;fs; Vw;gLj;jg;gLfpd;wd.
midj;J Gujq;fspYk; Kjyhd fl;likg;G fhzg;gLk;.
rhjhuz Gujk; mikg;gope;j Gujk;
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juk; 12, 13
njhFg;G : jpUkjp A. jtuQ;rpj;;, capupay; Mrpupau; (ah/aho;g;ghzk; ,e;Jf; fy;Yhup)
fzpdp tbtikg;G : jpU.r.uhjhutp j.njh.njh Mrpupau; (kd;/jiykd;dhH gpaH m.j.f. ghlrhiy> kd;dhH.)
Gujtif cjhuzk; njhopy;fs;
1 Cf;fp Gujk; Pepsin, Amylase capH ,urhaz jhf;fq;fis Cf;Ftpf;Fk;
2 fl;likg;G Gujk; nfuhw;wpd; Collagen cyHjiy jLf;Fk;>cWjp> Mjhuk; toq;Fk;
3 Nrkpg;G Gujk; Kl;il my;Gkpd;> Nfrpd; Kl;ilapy; Nrkpg;G Gujk;> ghypy; Nrkpg;G Gujk;
4 nfhz;L nry;yy; Gujk; rPuk; my;Gkpd;
O2, CO2 flj;jy;> nfhOg;gkpyq;fisf; flj;jy;
5 XNkhd; ,d;Rypd;>FSf;Nfhfd; FUjpapy; FSNfhR kl;lk; rPuhf;fg;gly;
6 RUf;Fk;/,aq;Fk; Gujk; Actin my;yJ Myosin jirehH RUf;fj;ij Vw;gLj;jy;
7 ghJfhg;G Gujk; Immuno globins gpwnghUl;fis mfw;Wjy;
Gujq;fspd; njhopy;fs;
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juk; 12, 13
njhFg;G : jpUkjp A. jtuQ;rpj;;, capupay; Mrpupau; (ah/aho;g;ghzk; ,e;Jf; fy;Yhup)
fzpdp tbtikg;G : jpU.r.uhjhutp j.njh.njh Mrpupau; (kd;/jiykd;dhH gpaH m.j.f. ghlrhiy> kd;dhH.)
caHntg;gepiyfspy; Guj %yf;$Wfs; milAk; khw;wq;fs; mtw;wpw;Fupa fhuzq;fs;
ehshe;j tho;f;ifKiw nraw;ghLfs;> caH mkpy> fhur; nrwpTfspy; Nkw;gb
tpisTfs;> caH fjpHtPr;R nraw;ghL / epiyikfspy; Nkw;gb tpisTfs; ciw
epiyikfspy; (mjpFspH) Nkw;gb tpisTfs; njhlHghf jfty; Nrfupj;J - jfty;
jpul;Lg; Gj;jfk; xd;iw jahupf;fTk;
Assignment
01