GUTPLUS

GUT GUT FLORAFLORA

Carbohydrate Carbohydrate fermentation and fermentation and absorptionabsorption

Prevent Prevent pathogenic pathogenic microbial microbial growthgrowth

ImmunityImmunity

Metabolic Metabolic functionfunction

Main Functions of GUT FLORA

Antibiotic Induced Diarrhoea

Antibiotics depletes normal Body's Lactobacilli

Alteration of colonic Microflora

Colonisation by Pathogens

Release of Toxins

Colonic mucosal injury and inflammation

Diarrhoea

Diarrhoea: It is a condition in which a sufferer has frequent watery loose stool more than three times a day.

GI Infections

Irritable Bowel Syndrome

A functional Bowel disorder in which abdominal pain is associated with the defecation or change in bowel habit.

Post Surgical Prophylaxis

• Post: After

• Surgical: Related to surgery.

• Prophylaxis: Treatment given to prevent the disease before it occurs.

Probiotics

• Pro : For & Bio : Life

• Live microorganisms thought to be healthy for the host.

• Criteria for bacteria to be included as a Probiotic

- Survives the stomach acid and bile

- Non-pathogenic and non-toxic

- Must be of human origin and should be able to survive in the intestinal ecosystem.

- Adheres to the intestinal lining

Production of inhibitory substances like bacteriocins, acidophylins

Reduction of pH

Blocking of adhesion sites

Degradation of toxin receptors

Competition for nutrients

MOA of Probiotics

Lactobacillus rhamnosus

Great ability to adhere to human mucosa cells

Found in human intestinal microflora

Add two points

Bifidobacterium longum

One of the most important residents in the human

gastrointestinal tract

Bifidobacterium longum is among the first to colonise

the sterile digestive tract of newborns and predominates

in breast-fed infants.

Saccharomyces boulardii

Saccharomyces boulardii is a strain of yeast

S. boulardii has been shown to maintain and restore the

natural flora.

Mechanism of action involves-inhibition of pathogen

adhesion, enhancement of the mucosal immune response.

Prebiotics

• Non-digestible food ingredients that stimulate the growth or activity of bacteria in the digestive system.

The Ideal Properties of Prebiotics :

● Should be a non-digestible food ingredient

● Should be principally an oligosaccharide

● Neither be hydrolysed nor be absorbed in the upper

part of the GI tract

● Should reduce the gut pH

● Should promote the growth and activity of probiotics

● Beneficially affects the host health

● Must be selectively fermented so that it is able to

alter the colonic microflora towards a healthier

composition

Polyols (sugar alcohols)XylitolSorbitolMannitol

Disaccharides Lactulose

Oligosaccharides

Fructo- oligosaccharides (FOS) – the most commonly used prebiotic

PolysaccharidesInulin.

Types of prebiotics

Gutplus

COMPOSITIONProbioticLactobacillus acidophilus - 0.75 billionLactobacillus rhamnosus - 0.75 billionBifidobacterium longum - 0.75 billionBifidobacterium bifidum - 0.50 billionSaccharomyces boulardii - 0.10 billion

PrebioticFructo Oligo Saccharides - 100 mg

Dosage :One to two capsules per day or as directed by physician.