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Harvard Medical School Curriculum Vitae

Date Prepared: August 26, 2016 Name: Richard Neal Mitchell Office Address: Department of Pathology, Brigham and Women's Hospital 77 Avenue Louis Pasteur/NRB 730D Boston, Massachusetts 02115 Home Address: 86 Macarthur Road Natick, MA 01760 Work Telephone: (617) 732-7510 (main department) (617) 525-4303 (office/laboratory) Work E-Mail: [email protected] Work FAX: (617) 525-4329 Place of Birth: Los Angeles, California Education: Year Degree Field of Study Institution 1975 B.S. with Honors Chemistry California Institute of

Technology, Pasadena, CA 1980 Ph.D. Cell Biology/Immunology The Rockefeller University, (PhD advisor: William Bowers) New York City, NY 1984 M.D. Medicine Harvard Medical School, Boston, MA Postdoctoral Training: Year(s) Title Specialty/Discipline Institution 1984-1985 Intern Medicine Beth Israel Hospital, Boston, MA 1985-1987 Resident Pathology Brigham and Women's Hospital June, 1987 to Chief Resident Pathology Brigham and Women's January, 1988 Hospital 1988-1990 Fellow Cardiac Pathology Brigham and Women's Hospital 1990-1992 Post-doc Fellow Pathology Brigham and Women's (PI: Abul Abbas) Hospital Faculty Academic Appointments: Year(s) Title Department Institution 1985-1990 Clinical Fellow Pathology Harvard Medical School 1990-1992 Instructor Pathology Harvard Medical School 1992-2000 Assistant Professor Pathology Harvard Medical School 1992- Affiliated Faculty Health Sciences Technology Harvard -MIT

Dr. Richard N. Mitchell Curriculum Vitae

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1998- Associate Director Health Sciences Technology Harvard Medical School 2000- Associate Professor Pathology Harvard Medical School 2007- Faculty Graduate Program in Biological Harvard Medical School and Biomedical Sciences 2007- Faculty Graduate Program in Human Harvard Medical School Biology and Translational Medicine 2007- Director HST Education and Curriculum Harvard Medical School Health Sciences and Technology 2009- Lawrence Health Sciences Technology Harvard Medical School J. Henderson Associate Professor of Pathology and

Health Sciences and Technology 2011- Lawrence Health Sciences Technology Harvard Medical School J. Henderson Professor of Pathology and

Health Sciences and Technology

Appointments at Hospitals and Affiliated Institutions: Year(s) Position Title Department and Division Institution 1991-2000 Associate Anatomic Pathology Brigham and Women's Staff Pathologist Hospital 1996-2009 Staff Scientist Biology Shriners Hospitals for Crippled Children Burns Institute, Boston, MA 1996-2009 Assistant Biologist Surgery Massachusetts General Hospital, Boston, MA 2000- Staff Pathologist Anatomic Pathology Brigham and Women's Hospital Other Professional Positions: Year(s) Position Title Institution 1999- Consultant Genzyme Corporation, Cambridge, MA 2003- Consultant Merck Pharmaceuticals, Rahway, NJ 2004 Consultant Vertex Pharmaceuticals, Cambridge, MA Major Administrative Leadership Positions: Year(s) Position Title Institution 1989- Co-Coordinator, Cardiology Division Brigham and Women’s Morbidity and Mortality Conference Hospital 1994- Co-Director, Human Pathology Course, HST-030 Harvard Medical School Harvard-MIT Health Science and Technology 1999- Director, Human Pathology Course, HST-030 Harvard Medical School Harvard-MIT Health Science and Technology 1998- Associate Master/Associate Director Harvard Medical School Health Sciences and Technology


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2007- Director, HST Education and Curriculum Harvard Medical School

Health Sciences and Technology 2009- Director, Research Career Development Brigham and Women’s Department of Pathology Hospital 2009- Co-Director, T32 Research Training Grant Brigham and Women's HL007627-26: Vascular, Pulmonary, Renal Injury Hospital 2009- Director, Intermediary Metabolism Course, HST-146 Harvard Medical School Harvard-MIT Health Science and Technology 2012- Vice Chair for Education Brigham and Women’s Department of Pathology Hospital 2016- Director, T32 Research Training Grant Brigham and Women's HL007627-26: Vascular, Pulmonary, Renal Injury Hospital Committee Service Year(s) Name of Committee Institution 1998- Member, Council of Student Advisors Harvard Medical School 1998- Member, Promotions and Review Board Harvard Medical School 1998- Chair, Health Sciences and Technology Harvard Medical School MD Board of Advisors 1998-2006 Co-Chair, Health Sciences and Technology Harvard Medical School MD Curriculum Committee 1998- Co-Chair, Health Sciences and Technology Harvard Medical School Advisory Committee 1998- Member, Health Sciences and Technology Harvard Medical School Faculty Committee 1998- Member, Health Sciences and Technology Harvard Medical School Curriculum Review Committees for Years 1 and 2 1998-2000 Member, Information Technology Initiative Harvard Medical School Educational Computing Committee

1999- Chair, Health Sciences and Technology Harvard Medical School Curriculum Retreat 2003-2007 Member, Committee on Assessment Harvard Medical School 2004-2006 Member, Blueprint Committee for Harvard Medical School Curriculum Restructuring 2007- Member, MD Curriculum Committee Harvard Medical School 2007- Chair, Health Sciences and Technology Harvard Medical School MD Curriculum Committee 2007- Member, Residency Selection Committee Brigham and Women’s Hospital 2008- Chair, Health Sciences and Technology Harvard Medical School MD Thesis and Honors Committee 2008- Member, Harvard Medical School Harvard Medical School Honors Committee


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2008- Member of various Thesis Defense Committees Harvard Medical School Honors Thesis Committee 2008-2015 Co-Chair, Milton Fund for Academic Support Harvard Medical School 2011-2015 Member, HMS Standing Longer Service Harvard Medical School Subcommittee of the Promotions, Reappointments, and Appointments Committee 2015- Member, Milton Fund for Academic Support Harvard Medical School Graduate Thesis Committee Service Year(s) Committee/Student; Advisor Institution 2002-2005 PhD Thesis Committee Member HST/MIT at Massachusetts

Stephen Walton; Martin Yarmush, PI General Hospital 2002-2006 PhD Thesis Committee Member HMS/Virology John Greenland; Norman Letvin, PI 2002-2006 PhD Thesis Committee Member HST/MIT at Massachusetts David Cochran; Rakesh Jain, PI General Hospital 2003-2007 PhD Thesis Committee Member HMS/BBS Arindel Maharaj; Patricia D’Amore, PI 2007-2012 PhD Thesis Committee Chair HST/MIT at Massachusetts Siraj Patel; Martin Yarmush, PI General Hospital 2008-2013 PhD Thesis Committee Member HMS/BBS Nathan Price; David Sinclair, PI 2009-2014 PhD Thesis Committee Chair HMS/BBS Allen Cheng; Patricia D’Amore, PI 2012-2014 PhD Thesis Committee Member HMS/BBS Cammi Valdez; Patricia D’Amore, PI 2013 PQE examiner HMS/BBS Anthony Nguyen; Daniel Finley, PI 2015- PhD Thesis Committee Chair HST/MIT Justin Lee; George Barbastathis, PI 2015- PhD Thesis Committee Chair HST/MIT Kelli Xu; Benjamin Vakoj, PI 2016- PhD Thesis Committee Chair HST/MIT Vicentius Jeremy Suhardi; PI Professional Societies Year(s) of Membership Society Name 1991- American Society of Investigative Pathology, Member 2005- American Society of Investigative Pathology, Education Committee 2016- American Society of Investigative Pathology, CME Oversight Sub- Committee 2008- American Society of Investigative Pathology, Director and Faculty, ASIP Summer Academy: Molecular Mechanisms of Human Disease: Injury, Inflammation, and Tissue Repair 2009-2015 American Society of Investigative Pathology, Chair of Education Committee 2009-2015 American Society of Investigative Pathology, Chair of On-line Education Sub-Committee


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2016- American Society of Investigative Pathology, Chair of Programming Committee 1991-2000 American Society for Cell Biology, Member 1992-2015 American Society of Transplantation, Member 2005-2015 AmericanSociety of Transplantation, Abstract Review and Session Chair 1992- International Academy of Pathology, Member

1992- Society for Cardiovascular Pathology, Member 2006-2008 Society for Cardiovascular Pathology, Councilor-at-Large 2010-2013 Society for Cardiovascular Pathology, Programming Chair 2011-2013 Society for Cardiovascular Pathology, Vice President 2013-2015 Society for Cardiovascular Pathology, President 2015-2017 Society for Cardiovascular Pathology, Membership Chair Grant Review Activities Year(s) of Membership Name of Committee Organization 2004- Ad hoc member NIH NIH AICS (Atherosclerosis and Inflammation of the Cardiovascular System) Study Section 2004- Ad hoc reviewer NIH Special Emphasis Panel Scientific Review Group-Muscle Physiology 2012 Ad hoc reviewer NIH/NIAID Program Project Grant The Inflammasome as a Therapeutic Target In Sterile Inflammatory Disorders Academic Review Activities Year(s) Name of Review Committee Organization 2010 External Reviewer University of Pittsburgh Graduate Training Program School of Medicine In Cellular and Molecular Pathology 2016 - Academic Advisory Board Eidgenössische Technische Bsc Medicine Hochschule (ETH) Zürich Editorial Activities: Ad hoc Reviewer 1994- American Journal of Pathology 1995- Journal of Immunology

Journal of Experimental Medicine 1996- Circulation 1997- Circulation Research Immunity 1999- Cellular Immunology 1999- Transplantation 2000- Journal of Clinical Investigation 2001- Physiological Genomics 2001- American Journal of Transplantation 2001- Nature Medicine 2002- Cardiovascular Pathology 2003- American Journal of Physiology-Cell Physiology 2003- Arteriosclerosis, Thrombosis, and Vascular Biology 2003- Transplant Immunology 2004- New England Journal of Medicine 2004- ASAIO Journal 2004- Cardiovascular Research


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2008- Basic Research in Cardiology 2011- Heart 2012- Journal of Cardiovascular Pharmacology 2012- Thrombosis and Haemostasis 2013- Archives of Pathology and Laboratory Medicine 2015- Histopathology Other Editorial Roles Year(s) Role Journal Name 2009- Editorial Board Member Cardiovascular Pathology 2010- Associate Editor Laboratory Investigation 2015- Associate Editor Cardiovascular Pathology Honors and Prizes: Year(s) Name of Honor/Prize Awarding Organization Achievement 1974 Tau Beta Pi Honor Society California Institute of Technology Scholarship 1975 Graduation with Honors California Institute of Technology Scholarship 1976-1980 A.R.C.S. Scholar The Rockefeller University Research 1978-1980 Sigma Xi Scientific Society The Rockefeller University Scholarship 1990-1992 Charles A. King Trust The Medical Foundation Research Fellowship 1995 Irving M. London Harvard-MIT Health Sciences Teaching Teaching Award and Technology 1998 Aesculapian Society Harvard Medical School Contribution to Community 2000 Faculty Prize for Harvard Medical School Teaching Excellence in Teaching

2002- Academy Scholar Harvard Medical School Scholarship 2003 HST Teaching Award Harvard-MIT Health Sciences Teaching and Technology

2004 Thomas A. McMahon Harvard-MIT Health Sciences Mentorship Mentoring Award and Technology 2004 Best Overall Lecturer Harvard-MIT Health Sciences Teaching and Technology 2005 Humanism in Medicine Harvard Medical School Mentorship Nominee with Special Mention 2007 Humanism in Medicine Harvard Medical School Mentorship Nominee with Special Mention 2007- Prize for Excellence in Harvard Medical School Teaching Teaching (Years 1 & 2) Nominee 2007 Biomedical Enterprise Harvard-MIT Health Sciences Teaching Program Teaching and Technology Award


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2013 Robbins Distinguished American Society of Education Educator Award Investigative Pathology 2016 Brindley Visiting University of Texas, Medical Education and Professor Branch-Galveston Research Report of Funded and Unfunded Projects Funding Information Past Funding Year(s) funded Role on project Funding source Total direct costs 1990-1992 Post-doctoral Fellow Charles A. King Trust The Medical Foundation B cell antigen presentation The goal of the study is to characterize intracellular pathways and transmembrane proteins involved in B cell antigen presentation 1992-1995 PI NIH R01 GM-47726 $615,000 Membrane receptor trafficking and antigen processing The goal of the work is to analyze the regulation of intracellular trafficking of membrane immunoglobulin as it relates to the processing and presentation of extracellular antigen via the MHCII pathway 1996-2000 PI NIH R01 GM-47726 $635,000 Membrane receptor trafficking and antigen processing The goal of the work is to analyze the regulation of intracellular trafficking of membrane immunoglobulin as it relates to the processing and presentation of extracellular antigen via the MHCII pathway 1995-2004 co-PI NIH R01 HL-43364 $2,000,000 Pathogenesis of transplant-associated arteriosclerosis The objectives are to examine the mechanisms, inflammatory cell populations, and cytokines that mediate transplant-associated arteriosclerosis in solid organ allografts 1998-2007 PI Shriner Burns Institute 8700 $1,000,000 Common hypercatabolic pathways in burn-induced muscle wasting and immune dysfunction The goals of the work are investigate the mechanisms and markers for skeletal muscle wasting and immune dysfunction following burn injury 2001-2005 co-Investigator NIH R01 HL-69484 Role of the T1/ST2 receptor in myocardial ischemia/reperfusion The objective of the work is to investigate the role of T1/ST2, an interleukin-1 receptor family member induced by mechanical strain and interleukin-1 in cardiac myocytes, following ischemia and reperfusion 2002-2006 co-Investigator NIH R01 HL-AI-51559 The role of new co-stimulatory pathways in graft rejection The goals of the work are to investigate the roles of newly-described co-stimulatory molecules (CD27/CD70, CD134/CD134L) in driving acute allograft rejection, as well as their contributions in the development of allograft arteriopathy 2003-2007 co-Investigator NIH R01 HL-67249 Inflammation and aortic aneurysm pathophysiology The objectives of the research are to investigate the mechanisms underlying formation of aortic aneurysms in humans, and in a murine transplant model 2003-2007 PI NIH R01 GM-67049 $900,000 Origin of intimal cells in allograft arteriopathy The goals of the work are to investigate the sources of intimal cells in allograft arteriopathy and to identify the mechanisms and pathways by which they are recruited 2006-2007 PI Advanced Cell Technology $50,000 Hemangioblasts in intimal hyperplastic lesions


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The goal of this work is to specifically test whether hemangioblasts cell lines administered to induce neovascularization in an ischemic vascular bed could exacerbate existing vascular pathology Current Funding Year(s) funded Role on project Funding source Total direct costs 2009- Director BWH Research Institute $57,000 Cardiovascular, diabetes, and metabolic diseases tissue repository The goal of this proposal is to develop a prospective, self-sustaining tissue repository for cardiovascular tissues, and materials associated with metabolic disease 2010-2015 co-Director NIH T32 HL-77627 $3,250,000 Vascular, pulmonary, and renal injury This is a Ruth L. Kirschstein Institutional National Service Award grant focused on the post-doctoral training of M.D., Ph.D., and M.D./Ph.D. candidates to pursue independent careers as successful physician-scientists 2016-2020 Director NIH T32 HL-77627 $3,250,000 Vascular, pulmonary, and renal injury This is a Ruth L. Kirschstein Institutional National Service Award grant focused on the post-doctoral training of M.D., Ph.D., and M.D./Ph.D. candidates to pursue independent careers as successful physician-scientists Past Unfunded Projects Year(s) Role on project Title of project 2004-2016 PI Identifying molecular markers of humoral rejection of cardiac allografts The objective is to identify potential markers of humoral rejection and allograft arteriopathy following cardiac transplantation, using myocardial biopsy specimens, surgically explanted hearts and autopsy material. 2009-2016 PI Identifying molecular pathways of osseous metaplasia in valvular calcific degeneration The goal of this work is to identify molecular pathways involved in chronic valvular calcific degeneration. 2009-2016 co-Investigator Tissue-engineered heart regeneration by human ES and iPS cells The objectives are to characterize inflammatory mediators that may adversely impact myocardial stem cell engraftment or expansion in areas of myocardial injury 2009-2016 co-Investigator Cardiac progenitor cell therapy for advanced ischemic cardiomyopathy The goals of the project are to develop therapeutic approaches and pathologic analyses for the administration of myocardial stem cells in human ischemic cardiomyopathy patients 2010-2016 co-Investigator Characterization of myocardial infarct heterogeneity and

the peri-infarction zone assessed by contrast-enhanced cardiovascular magnetic resonance

The goals of the project are the development and validation of in vivo imaging modalities to assess risk of arrhythmia status-post infarction 2013-2016 co-Investigator The role of neutrophil NETs in human thrombosis and

embolism


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The goals of the project are evaluating the presence and significance of neutrophil extracellular traps (NETs) in human thromboembolic disease Current Unfunded Projects 2009- Pathologist Cardiac sarcoidosis diagnosis and management The goal is to standardize the BWH strategy for diagnosis, treatment and follow up of cardiac sarcoidosis 2009- Pathologist Novel magnetic resonance imaging marker of myocardial fibrosis The goal is to correlate specific magnetic resonance imaging signatures with pathologic substrate and risk of arrhythmia 2009- Pathologist The vascular pathogenesis of Hutchison-Gilford progeria The goal is to characterize the pathogenic mechanisms underlying the accelerated vascular pathology in progeria 2010- co-Investigator A novel magnetic resonance imaging marker of

myocardial fibrosis and myocyte hypertrophy The goals of the project are the development and validation of in vivo imaging modalities to assess myocardial fibrosis and myocyte size 2015- co-Investigator Endothelial microchimerism in human cardiac allografts The goals of the project are to evaluate the presence of recipient endothelial cells in human cardiac allografts, correlating it with acute perioperative injury, and incidence of acute cellular and humoral rejection. Report of Local Teaching and Training Teaching of Students in Courses Harvard Medical School Year(s) Course title Role in course Level of effort Type of student 1982 Microbiology Laboratory instructor 6 hr/wk x 8 wks and Section Preceptor 1st year MD students 1984 Introduction to Clinical Tutor 10 hr/wk x 8 wks Clinical Medicine 2nd year MD students 1985-1993 General Pathology Laboratory instructor 6 hr/wk x 8 wks 2nd year MD students 1988- Human Pathology Lecturer and laboratory 8 hr/wk x 12 wks HST030 1st year MD students 1988-2006 Pathology clinical Faculty 2 hr/month elective, CV Pathology 4th year MD students Brigham and Women’s Hospital 1996- Cardiovascular Faculty 3 hr/wk x 2 wks Pathophysiology 1st year MD students HST090


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2000 General Pathology Faculty 3 hr lecture/discussion 1st year MD students

2001- Biomaterials and Faculty 6 hr total lecture/discussion Tissue Engineering in 1st and 2nd year MD and Medical Devices and PhD students Artificial Organs HST-521 2001- Human Pathology Lecturer and laboratory 4 hr total lecture/discussion HST035 1st and 2nd year PhD students 2005-2015 Immunology, Faculty 4 hr total lecture/discussion Microbiology, and 1st year MD students Pathology Other Harvard University courses Year(s) Course title Role in course Level of effort Type of student 1999- Tutorial in Medical Faculty 3 hr lecture/discussion Engineering and 1st and 2nd year PhD Medical Physics students HST-595 2015- Immunology/ Faculty 3 hr lecture/discussion Masters in Medical Masters students Sciences Curriculum Courses outside of Harvard University Year(s) Course title Role in course Level of effort Type of student 1997-2001 Cardiovascular Faculty 5 hr lecture/discussion Pathophysiology for PhD and engineering Engineers and students at MIT Physical Scientists HST 090s 2000-2011 The Art and Science Faculty 2 hr lecture/discussion

of Medicine Undergraduate students at MIT

2014- Medicine for Managers Faculty 3 hr lecture/discussion and Entrepreneurs MBA students at MIT/Sloane Formal Teaching of Residents, Clinical Fellows, and Research Fellows Year(s) Title Institution Level of effort Type of audience 1989- Cardiovascular Brigham and Women’s 3 hour lecture/discussion pathology Hospital Pathology Residents 1999- Cardiovascular Brigham and Women’s 2 hour lecture/discussion pathology Hospital Cardiology Fellows Clinical Supervisory and Training Responsibility Year(s) Type of responsibility Institution Level of effort


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1990- Cardiovascular surgical Brigham and Women’s 10 hr/wk x 15 wk/yr pathology sign-out Hospital 1990- Autopsy service Brigham and Women’s 10 hr/wk x 9 wk/yr Hospital Laboratory and Other Research Supervisory and Training Responsibility Year(s) Type of responsibility Level of effort 1996- Supervision of medical or graduate students Daily mentorship 1996- Supervision of post-doctoral research fellows Daily mentorship 2003-2007 Supervision of undergraduate students Daily mentorship in summers Formally Supervised Trainees Year(s) Name and degrees Current position 1996-1998 Hiroaki Nagano, M.D., Ph.D. Associate Professor, Department of Surgery Graduate School of Medicine, Osaka University Medical School, Japan

Published five manuscripts including three in American Journal of Pathology, and one in Journal of Clinical Investigation

1996-1998 Marta Taylor Becker, M.D. Attending Surgeon in Otolaryngology, Abington Memorial Hospital, E. Norriton, PA Published one manuscript in American Journal of Pathology 1997-1999 Satoru Hasegawa, M.D. Director, Hasegawa Clinic, Cardiology and Vascular Surgery, Nagano, Japan

Published five manuscripts including four in American Journal of Pathology, and one in Journal of Clinical Investigation 1997-2005 Koichi Shimizu, M.D., Ph.D. Instructor in Medicine, Harvard Medical School Published eighteen manuscripts including in Nature Medicine, Circulation, Journal of Clinical Investigation, Journal of Immunology, and American Journal of Pathology;

Young Investigator Awards from American Society of Transplantation, and the American Heart Association, and a research award from the Roche Organ Transplant Research Foundation

1998-2000 Jennifer Stinn, M.D. Practicing primary care pediatrician British Columbia, Canada Published three manuscripts in American Journal of Pathology 1998-2001 Yutaka Furukawa, M.D., Ph.D. Director, Department of Cardiology Kobe City Medical Center General Hospital

Published six manuscripts including three in American Journal of Pathology, and one in Journal of Immunology

1998-2001 Gerold Becker, M.D. Director, Dialysezentrum Wattenscheid, Bochum, Deutschland Published six manuscripts including five in American Journal of Pathology 1999-2001 Toufic Nashar, Ph.D. Research Affiliate, Wadsworth Center, Albany, NY Published two manuscripts 1999-2002 Sundar Madihally, Ph.D. Assistant Professor, School of Chemical Engineering, Okla.State Univ., Stillwater, OK


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Published three manuscripts 2000-2002 Jun-Ichi Suzuki, M.D. Director and Project Associate Professor Department of Advanced Clinical Science and Therapeutics, University of Tokyo, Japan Published one manuscript in American Journal of Transplantation 2000-2006 Emanuela Binello, M.D., Ph.D. Resident in Neurosurgery, Mt. Sinai Hospital New York City, NY PhD thesis advisor; published one manuscript in Applied Radiation and Isotopes 2003-2005 Xuanbao Duan Ph.D. Assistant Professor, Department of Biochemistry

Temple University School of Medicine Philadelphia, PA Published one manuscript

2003-2006 Ravi Shah, M.D. Research Fellow in Cardiology, Massachusetts General Hospital, Boston, MA Published one manuscript in Cardiovascular Pathology 2010-2013 Chen Zhang, M.D. Liver Transplant Surgeon Tongji Medical College Huazhong University of Science & Technology Formal Teaching of Peers (e.g., CME and other continuing education courses) Year(s) Title or topic Number of talks Course name Location Sponsor 1989- Cardiovascular Pathology 6-12 X per year Cardiology M&M Conference Brigham and Women’s Hospital BWH Cardiology 1989- Clinicopathologic Board Vignettes 1 X per year Intensive Rev. Int. Med Boston Harvard Medical School Local Invited Presentations Year(s) Title of presentation Type of presentation Department and Institution where presented Sponsor 2001, 2003, 2006 Cardiovascular Pathology Grand Rounds Department of Cardiology W. Roxbury VA Hospital None 2006 Learning From Rejection Research Forum Schepens Eye Institute None 2006 Stem Cells in Cardiovascular Research Seminar Boston Medical Center Pathology None 2007 Inflammation and the Research Conference Harvard Medical School Complications of Transplantation Texas Heart Institute 2007 Cardiac Pathology McCain Lecture Lahey Clinic Clinical Conference Cardiology Grand Rounds None 2009 What Transplantation Teaches Research Seminar Vascular Biology Seminar Us About Other Vascular None Harvard Medical School Pathologies 2010 The Pathology of Acute Coronary Clinical Conference/ BRI Cardiovascular Seminar Syndromes and Myocardial Research Seminar Brigham and Women’s Hospital Infarction None


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2010 What Transplantation Teaches Research Seminar CLS/Beth Israel-Deaconess Us About Other Vascular None Medical Center Cardiovascular Pathologies Seminar Series 2013 Learning Opportunities from McCain Lecture Lahey Clinic Cardiac Pathology Clinical Conference Cardiology Grand Rounds None 2014 What Transplantation Teaches Research Seminar CHF/Heart Transplant Us About Other Vascular None Division Pathologies Brigham and Women’s Hospital 2015 Clinical Conference Vascular Medicine Division The Pathology of None Brigham and Women’s Hospital Peripheral Vascular Disease: Atherosclerosis and Beyond 2016 Forensic Pathology Clinical Conference Office of the Chief Medical Grand Rounds None Examiner-Boston Greatest Hits of Cardiovascular Pathology Report of Regional Invited Teaching and Presentations Year(s) Title of presentation Type of presentation Location Sponsor 2003 Allograft Arteriopathy Pathology Grand Rounds Weill Medical College, NYC, NY Department of Pathology 2007 Stem Cells in Cardiovascular Research Seminar Temple University Med. Ctr. Pathology Department of Medicine 2009 Learning From Rejection Scientific Symposium, Plenary

Rhode Island Hospital Speaker Brown Medical School Department of Surgery Report of National Invited Teaching and Presentations Year(s) Title of presentation Type of presentation Location Sponsor 1993 Short Course on Immune- Teaching New Orleans Mediated Diseases US-Canadian Assoc. Pathology 1997-2007; 2011 (2 X per year) “Basic Immunology” Teaching Phoenix, Arizona “Mechanisms of Rejection” North American Transplant Coord. “HLA, PRA, and Cross-Matching” 1998 Forensic Challenges in Pathology Symposium Boston US-Canadian Assoc. Pathology 2002 Endothelium: Inflammation and Symposium Chicago Repair American Transplant Society 2003 Inflammation in Cardiovascular Specialty Conference Washington, DC Disease US-Canadian Assoc. Pathology 2003 Pathobiology for Basic Teaching Seminar


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Seattle Scientists: Acute and Chronic Am. Soc. Invest. Path. Inflammation 2004 Pathobiology of Transplantation Plenary Speaker Kansas City Midwest Transplant Network 2004 Stem Cells and Cardiovascular Specialty Conference Vancouver Regeneration US-Canadian Assoc. Pathology 2004 Stem Cells in Vascular Pathology NIH Panel on Progeria Washington, DC Progeria Research Foundation 2006 Learning From Rejection Plenary Speaker Chicago North American Transplant Coord. 2008, 2010 Atherosclerosis Teaching Washington, DC Am. Soc. Invest. Path. 2008 Pathophysiology of Transplant Plenary Speaker Boston Rejection North American Transplant Coord. 2008, 2010 American Society of Director and Faculty, Washington, D.C. Investigative Pathology ASIP Summer Academy: Molecular Mechanisms of Human

Disease: Injury, Inflammation, Stem Cells, and Tissue Repair

2011 What Transplantation Teaches Research Seminar UC Irvine Medical Center Us About Other Vascular Irvine, CA Pathologies 2013 What Transplantation Teaches Cardiology Grand Rounds Case Western Reserve Us About Other Vascular Cleveland, OH Pathologies 2013 Comparing the Vascular Plenary Speaker Progeria Research Foundation Pathology of Progeria and Bethesda, MD Atherosclerosis: A Pathologist’s Perspective 2015 Atherosclerosis: Plaque Attack Teaching University of Chicago Pathobiology Insights Inform Medical School Diagnosis and Therapy Chicago, IL 2015 Neutrophil Extracellular Traps Plenary Speaker Boston, MA in VTE: A Link Between Thrombosis and Thromboembolism Inflammation and Thrombosis Course 2016 Atherosclerosis: The Wound Teaching University of Chicago That Will Not Heal Medical School Chicago, IL 2016 What Transplantation Teaches Brindley Visiting Professor University of Texas Us About Other Vascular Distinguished Seminar Series Medical Branch Pathologies 2016 Atherosclerosis: The Wound Brindley Visiting Professor University of Texas That Will Not Heal Brindley Lecture Medical Branch 2016 Neutrophil Extracellular Traps Brindley Visiting Professor University of Texas in VTE: A Link Between Medical Branch Inflammation and Thrombosis


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Report of International Invited Teaching and Presentations Year(s) Title of presentation Type of presentation Location Sponsor 1995 Cytokines as Modulators of Transplant Symposium Bermuda Vascular Disease Ohio State Univ./R.G. Landes Co. 1997 Immune-mediated Injury Invited speaker Wilbad Kreuth, Germany in Bioprosthetic Valve Failure Intl Soc. Appl Cardiovascular Biol. 2001 Cytokines in Chronic Transplant Invited Speaker Ricksgransen, Sweden Dysfunction Alexis Carrel Conference 2001 Autoimmune Cardiovascular Invited Speaker Stockholm, Sweden Diseases Intl Congress of Immunology 2004 Endothelial and Smooth Muscle Invited Speaker Padua, Italy Progenitor Cells Assoc. Eur. Cardiovasc. Pathol. 2005 “Learning From Rejection” Plenary Speaker Toyama, Japan “Anatomy at Harvard Medical Japanese Assoc. of Anatomists School” 2006 Allograft Arteriopathy Plenary Speaker Boston World transplant Congress 2011-2012 Fundamentals of Pathobiology Invited Faculty Madrid, Spain M+Vision Program in Physics and Engineering Report of Clinical Activities Current Licensure and Certification: 1986-present Board of Registration in Medicine, Commonwealth of Massachusetts 1988 American Board of Pathology (Anatomic Pathology) Practice Activities: Type of activity Practice setting Name and location Level of activity Autopsy attending Hospital Pathology one week of every six Brigham and Women’s Cardiovascular Hospital Pathology one week of every three Surgical Pathology Brigham and Women’s Report of Education of Patients and Service to the Community Recognition: Year Name of award Organization conferring recognition 2000 Who’s Who in America Who’s Who National Registry


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Report of Scholarship Peer-Reviewed Publications: Research investigations:

1. Mitchell RN, Bowers WE. Cell surface glycoproteins of rat lymphocytes. I. Correlation of mitogenic

stimulation by periodate or neuraminidase and galactose oxidase with the presence of papain-sensitive glycoproteins. J. Immunol. 1978; 121: 2181-2192.

2. Mitchell RN, Bowers WE. Cell surface glycoproteins of rat lymphocytes. II. Protease-sensitive

glycoproteins associated with mitogenic stimulation by periodate or neuraminidase plus galactose oxidase. J. Immunol. 1980; 124: 2632-2640.

3. Mitchell RN, Harrison EH, Bowers WE. The use of radioactive cysteine methyl ester for labeling

glycosylated molecules oxidized by periodate or neuraminidase plus galactose oxidase. Arch. Biochem. Biophys. 1984; 229: 544-554.

4. Shaw AC, Mitchell RN, Weaver YK, Campos-Torres J, Abbas AK, Leder P. Mutations of

immunoglobulin transmembrane and cytoplasmic domains: effects on intracellular signaling and antigen presentation. Cell 1990; 63: 381-392.

5. Mitchell RN, Shaw AC, Weaver YK, Leder P, Abbas AK. Cytoplasmic tail deletion converts

membrane immunoglobulin to a phosphatidylinositol-linked form lacking signaling and efficient antigen internalization functions. J. Biol. Chem. 1991; 266: 8856-8860.

6. Grupp SA, Campbell K, Mitchell RN, Cambier JC, Abbas AK. Signaling-defective mutants of the B

lymphocyte antigen receptor fail to associate with Ig-α and Ig-β/γ. J. Biol. Chem. 1993; 268: 25776-25779.

7. Grupp SA, Mitchell RN, Schreiber KL, McKean DJ, Abbas AK. Molecular mechanisms that control

expression of the B lymphocyte antigen receptor complex. J. Exp. Med. 1995; 181:161-168. 8. Barnes KA, Mitchell, RN. Detection of functional class II-associated antigen: role of a low density

endosomal compartment in antigen processing. J. Exp. Med. 1995; 181: 1715-1727. 9. Mitchell RN, Barnes KA, Grupp SA, Sanchez M, Misulovin Z, Nussenzweig MC, Abbas AK. Intracellular targeting of antigens internalized by membrane immunoglobulin in B lymphocytes. J. Exp.

Med. 1995; 181: 1705-1714. 10. Mitchell RN, Jonas RA, Schoen FJ. Structure-function correlations in cryopreserved allograft cardiac valves. Annals Thoracic Surg. 1995; 60: S108-S113. 11. Schoen FJ, Mitchell RN, Jonas RA. Pathological considerations in cryopreserved allograft heart

valves. J. Heart Valve Dis. 1995; 4 (Suppl. 1): S72-S75. 12. Bartlett TG, Mitchell R, Friedman PL, Stevenson WG. Histological evolution of radiofrequency lesions

in an old human myocardial infarct causing ventricular tachycardia. J. Cardiovasc. Electrophys. 1995; 6: 625-629.

13. Meckel CR, Anderson TJ, Mudge GH, Mitchell RN, Yeung AC, Selwyn AP, Ganz P, Simon DI.

Hemostatic/fibrinolytic predictors of allograft coronary artery disease after cardiac transplantation. Vasc. Med. 1997; 2: 306-312.

14. Nagano H, Mitchell RN, Taylor MK, Hasegawa S, Libby P. Interferon-gamma deficiency prevents

coronary arteriosclerosis but not myocardial rejection in transplanted mouse hearts. J. Clin. Invest. 1997; 100: 550-557.

15. Reul RM, Fang JC, Denton MD, Geehan C, Long C, Mitchell RN, Ganz P, Briscoe DM. CD40 CD40

ligand (CD154) are coexpressed on microvessels in vivo in human cardiac allograft rejection. Transplantation 1997; 64: 1765-1774.

16. Mitchell RN, Jonas RA, Schoen FJ. Pathology of explanted cryopreserved allograft human valves:

comparison with aortic valves from orthotopic heart transplants. J. Thorac. Cardiovasc. Surg. 1998; 115: 118-127.


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17. Nagano H, Libby P, Taylor MK, Hasegawa S, Stinn JL, Tilney NL, Mitchell RN. Coronary

arteriosclerosis following T cell-mediated injury in murine cardiac allografts: Role of interferon-gamma. Am. J. Pathol. 1998; 152: 1187-1197.

18. Rosenson-Schloss RS, Russo GA, Vitolo JL, Mitchell RN, and Yarmush ML. Effect of physical stress

on immune function in cell lines: B7-2 molecules contribute to augmented antigen presentation induced by heat shock. Tiss. Engineer. 1998; 4: 85-99.

19. Hasegawa S, Becker G, Nagano H, Libby P, Mitchell RN. Pattern of graft- and host-specific MHC

class II expression in long-term murine cardiac allografts: Origin of inflammatory and vascular wall cells. Am. J. Pathol. 1998; 153: 69-79.

20. Riese RJ, Mitchell RN, Villadangos JA, Shi GP, Palmer JT, Karp ER, DeSanctis GT, Ploegh HL,

Chapman HA.. Cathepsin S activity regulates antigen presentation and immunity. J. Clin. Invest. 1998; 101: 2351-2363.

21. Stinn JL, Taylor MK, Becker G, Nagano H, Hasegawa S, Furukawa Y, Shimizu K, Libby P, Mitchell

RN. Interferon-γ-secreting T-cell populations in rejecting murine cardiac allografts: Assessment by flow cytometry. Am. J. Pathol. 1998; 153: 1383-1392.

22. Drake JR, Lewis TA, Condon KB, Mitchell RN, Webster P. Involvement of MIIC-like late endosomes in

B-cell receptor-mediated antigen processing in murine B cells. J. Immunol. 1999; 162: 1150-1155. 23. Nagano H, Tilney NL, Stinn JL, Becker G, Hasegawa S, Libby P, Mitchell RN. Deficiencies of IL-4 or

TNF-α receptor-1 do not diminish graft arteriosclerosis in cardiac allografts. Transplant. Proc. 1999; 31:152.

24. Delacretaz E, Stevenson WG, Winters GL, Mitchell RN, Stewart S, Lynch K, Friedman PL. Ablation of

ventricular tachycardia with a saline-cooled radiofrequency catheter: Anatomic and histologic characteritics of the lesions in humans. J. Cardiovasc. Electrophysiol. 1999; 10: 860-865.

25. Mandelbrot DA, Furukawa Y, McAdam AJ, Alexander SI, Libby P, Mitchell RN, Sharpe AH. Expression

of B7 molecules in recipient, not donor, mice determines the survival of cardiac allografts. J. Immunol. 1999; 163: 3753-3757.

26. Chen RH, Mitchell RN, Kadner A, Adams DH. Differential galactose α(1,3) galactose expression by

porcine cardiac vascular endothelium. Xenotransplantation. 1999; 6: 169-172. 27. Cheng PC, Dykstra ML, Mitchell RN, Pierce SK. A role for lipid rafts in BCR signaling and antigen

targeting. J. Exp. Med. 1999; 190: 1549-1560. 28. Furukawa Y, Becker G, Stinn JL, Shimizu K, Libby P, Mitchell RN. IL-10 augments allograft arterial

disease: Paradoxical effects of IL-10 in vivo. Am. J. Pathol. 1999; 155: 1929-1940. 29. Grosjean SA, Arstall MA, Mitchell RN, Klappacher GW, Kelly RA, Pfeffer MA, Pfeffer JM. Inducible

nitric oxide synthase and tumor necrosis factor in animal models of myocardial necrosis induced by coronary artery ligation or isoproterenol injection. J Card. Fail. 1999; 5:236-45.

30. Furukawa Y, Mandelbrot DA, Libby P, Sharpe AH, Mitchell RN. Association of B7-1 costimulation with

the development of graft arterial disease: Studies using mice lacking B7-1, B7-2, or B7-1/B7-2. Am. J. Pathol. 2000; 157: 473-484.

31. Chen RH, Kadner A, Mitchell RN, Adams DH. Mechanisms of delayed rejection in transgenic pig-to-

primate cardiac xenotransplants. J. Surg. Res. 2000; 90: 119-125. 32. Chen RH, Kadner A, Mitchell RN, Adams DH. Fresh porcine valves are not rejected in primates. J.

Thorac. Cardiovasc. Surg. 2000; 119: 1216-1220. 33. Kadner A, Chen RH, Mitchell RN, Adams DH. Lack of ABH-antigen expression on human cardiac

valves. J. Heart Valve Dis. 2000; 9: 512-516. 34. Shimizu K, Schonbeck U, Mach F, Libby P, Mitchell RN. Host CD40 ligand deficiency induces long-

term allograft survival and donor-specific tolerance in mouse cardiac transplants, but does not prevent graft arteriosclerosis. J. Immunol. 2000; 165: 3506-3518.


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35. Zhao X-M, Hu Y, Miller GG, Mitchell RN, Libby P. Association of Thrombospondin-1 and cardiac

allograft vasculopathy in human cardiac allografts. Circulation. 2001; 103: 525-531. 36. Madihally SV, Toner M, Yarmush ML, Mitchell RN. Peripheral blood mononuclear cells exhibit

hypercatabolic activity in response to thermal injury correlating with diminished MHC I expression. J Trauma. 2001;50:500-9.

37. Mandelbrot DA, Oosterwegel MA, Shimizu K, Yamada A, Freeman GJ, Mitchell RN, Sayegh MH,

Sharpe AH. B7-dependent T cell costimulation in mice lacking CD28 and CTLA4. J Clin. Invest. 2001; 107: 881-887.

38. Nashar TO, Betteridge ZE, Mitchell RN. Evidence for a role of ganglioside GM1 in antigen

presentation: Binding enhances presentation of Escherichia coli enterotoxin B subunit (EtxB) to CD4+ T cells. Int. Immunol. 2001; 13: 541-551.

39. Delfs MW, Furukawa Y, Mitchell RN, Lichtman AH. CD8+ T cell subsets TC1 and TC2 cause different

histopathologic forms of murine cardiac allograft rejection. Transplantation. 2001; 71:606-10. 40. Kadner A, Chen RH, Mitchell RN, Adams DH. Homograft crossmatching is unnecessary due to the

absence of blood group antigens. Ann. Thorac. Surg. 2001; 71:S349-52. 41. Shimizu K, Sugiyama S, Aikawa M, Fukumoto Y, Rabkin E, Libby P, Mitchell RN. Host bone marrow

cells are a source of donor intimal smooth muscle-like cells in murine aortic transplant arteriopathy. Nature Med. 2001; 7:738-741.

42. Furukawa Y, Libby P, Stinn JL, Becker G, Mitchell RN. Cold ischemia induces isograft arteriopathy,

but does not augment allograft arteriopathy arteriopathy in non-immunosuppressed hosts. Am. J. Pathol. 2002; 160:1077-1087.

43. Nashar TO, Betteridge ZE, Mitchell RN. Antigen binding to GM1 ganglioside results in delayed

presentation: minimal effects of GM1 on presentation of antigens internalized via other pathways. Immunol. 2002; 106:60-70.

44. Solomon V, Madihally S, Mitchell RN, Yarmush M, Toner M. Antiproteolytic action of insulin in burn

injured rats. J.Surg. Res. 2002;105: 234-242. 45. Madihally SV, Toner M, Yarmush ML, Mitchell RN. Interferon gamma modulates trauma-induced

muscle wasting and immune dysfunction. Ann. Surg. 2002; 236:649-657. 46. Zhao DX, Hu Y, Miller GG, Luster AD, Mitchell RN, Libby P. Differential expression of the IFN-gamma-

inducible CXCR3-binding chemokines, IFN-inducible protein 10, monokine induced by IFN, and IFN-inducible T cell alpha chemoattractant in human cardiac allografts: association with cardiac allograft vasculopathy and acute rejection. J. Immunol. 2002; 169:1556-1560.

47. Halamay KE, Kirkman RL, Sun L, Yamada A, Fragoso RC, Shimizu K, Mitchell RN, McKay DB. CD8 T

cells are sufficient to mediate allorecognition and allograft rejection. Cell. Immunol. 2002;216: 6-14. 48. Sayegh MH, Wu Z, Hancock WW, Langmuir PB, Mata M, Sandner S, Kishimoto K, Sho M, Palmer E,

Mitchell RN, Turka LA. Allograft rejection in a new allospecific CD4+ TCR transgenic mouse.Am. J. Transplant. 2003 ; 3:381-389.

49. Suzuki JI, Cole SE, Batirel S, Kosuge H, Shimizu K, Isobe M, Libby P, Mitchell RN. Tumor necrosis

factor receptor -1 and -2 double deficiency reduces graft arterial disease in murine cardiac allografts. Am. J. Transplant. 2003; 3:968-976.

50. Shimizu K, Aikawa M, Takayama K, Libby P, Mitchell RN. Direct anti-inflammatory mechanisms

contribute to attenuation of experimental allograft arteriosclerosis by statins. Circulation 2003; 108:2113-2120.

51. Feinberg MW, Shimizu K, Lebedeva M, Haspel R, Takayama K, Chen Z, Frederick JP, Wang XF,

Simon DI, Libby P, Mitchell RN, Jain MK. Essential role for Smad3 in regulating MCP-1 expression and vascular inflammation. Circ. Res. 2004;94:601-608.

52. Furukawa Y, Cole SE, Shah RV, Fukumoto Y, Libby P, Mitchell RN. Wild-type but not interferon-

gamma-deficient T cells induce graft arterial disease in the absence of B cells. Cardiovasc. Res. 2004; 63:347-56.


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53. Shimizu K, Shichiri M, Libby P, Lee RT, Mitchell RN. Th2-predominant inflammation and blockade of

IFN-gamma signaling induce aneurysms in allografted aortas. J. Clin. Invest. 2004;114:300-8. 54. Binello E, Mitchell RN, Harling OK. T cell uptake for the use of boron neutron capture as an

immunologic research tool. Appl. Radiat. Isot. 2004;61:959-62. 55. Batirel HF, Batirel S, Mitchell RN, Swanson SJ. Interferon-gamma knockout fails to confer protection

against obliteration in heterotopic murine tracheal allografts. J. Heart Lung Transplant. 2005; 24:658-664.

56. Monahan TS, Phaneuf MD, Contreras MA, Andersen ND, Popescu-Vladimir A, Bide MJ, Dempsey DJ,

Mitchell RN, Hamdan AD, Logerfo FW. In Vivo Testing of an Infection-Resistant Annuloplasty Ring. J. Surg. Res. 2006; 140-145.

57. Sugiyama S, Kugiyama K, Nakamura S, Kataoka K, Aikawa M, Shimizu K, Koide S, Mitchell RN,

Ogawa H, Libby P. Characterization of smooth muscle-like cells in circulating human peripheral blood. Atherosclerosis 2006; 9: 351-362.

58. Song L, DePalma SR, Kharlap M, Zenovich AG, Cirino A, Mitchell R, McDonough B, Maron BJ,

Seidman CE, Seidman JG, Ho CY. Novel locus for an inherited cardiomyopathy maps to chromosome 7. Circulation. 2006; 113:2186-92.

59. Duan X, Yarmush D, Leeder A, Yarmush ML, Mitchell RN. Burn-induced immunosuppression:

attenuated T cell signaling independent of IFN-gamma- and nitric oxide-mediated pathways. J. Leukoc. Biol. 2008; 83:305-313.

60. Shimizu K, Libby P, Shubiki R, Sakuma M, Wang Y, Asano K, Simon DI, Mitchell RN. Leukocyte

integrin Mac-1 promotes acute cardiac allograft rejection. Circulation. 2008;117:1997-2008. 61. Thurberg BL, Fallon JT, Mitchell R, Aretz T, Gordon RE, O'Callaghan MW. Cardiac microvascular

pathology in Fabry disease: evaluation of endomyocardial biopsies before and after enzyme replacement therapy. Circulation. 2009;119:2561-2567.

62. Shimizu K, Minami M, Shubiki R, Lopez-Ilasaca M, MacFarlane L, Asami Y, Li Y, Mitchell RN, Libby

P. CC chemokine receptor-1 activates intimal smooth muscle-like cells in graft arterial disease. Circulation. 2009;120:1800-1813.

63. Okamoto Y, Christen T, Shimizu K, Asano K, Kihara S, Mitchell RN, Libby P. Adiponectin inhibits

allograft rejection in murine cardiac transplantation. Transplantation. 2009;88:879-883. 64. Steven D, Roberts-Thomson KC, Seiler J, Inada K, Tedrow UB, Mitchell RN, Sobieszczyk PS,

Eisenhauer AC, Couper GS, Stevenson WG. Ventricular tachycardia arising from the aortomitral continuity in structural heart disease: characteristics and therapeutic considerations for an anatomically challenging area of origin. Circ Arrhythm Electrophysiol. 2009;2:660-666.

65. Olive M, Harten I, Mitchell R, Beers JK, Djabali K, Cao K, Erdos MR, Blair C, Funke B, Smoot L,

Gerhard-Herman M, Machan JT, Kutys R, Virmani R, Collins FS, Wight TN, Nabel EG, Gordon LB. Cardiovascular pathology in Hutchinson-Gilford progeria: correlation with the vascular pathology of aging. Arterioscler Thromb Vasc Biol. 2010;30:2301-2309

66. Coelho-Filho OR, Mongeon FP, Mitchell RN, Blankstein R, Jerosch-Herold M, Kwong RY. Images in

cardiovascular medicine. Löffler endocarditis presenting with recurrent polymorphic ventricular tachycardia diagnosed by cardiac magnetic resonance imaging. Circulation. 2010;122:96-99.

67. D'Amario D, Fiorini C, Campbell PM, Goichberg P, Sanada F, Zheng H, Hosoda T, Rota M, Connell

JM, Gallegos RP, Welt FG, Givertz MM, Mitchell RN, Leri A, Kajstura J, Pfeffer MA, Anversa P. Functionally competent cardiac stem cells can be isolated from endomyocardial biopsies of patients with advanced cardiomyopathies. Circ. Res. 2011; 108:857-861

68. Shimizu K, Libby P, Rocha VC, Folco EJ, Shubiki R, Grabie N, Jang S, Lichtman AH; Shimizu A, Hogg

N, Simon DI, Croce K, Mitchell RN. Loss of myeloid related protein-8/14 exacerbates cardiac allograft rejection. Circulation 2011; 124:2920-3292

69. Herman DS, Lam L, Taylor MR, Wang L, Teekakirikul P, Christodoulou D, Conner L, DePalma SR,

McDonough B, Sparks E, Teodorescu DL, Cirino AL, Banner NR, Pennell DJ, Graw S, Merlo M, Di


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Lenarda A, Sinagra G, Bos JM, Ackerman MJ, Mitchell RN, Murry CE, Lakdawala NK, Ho CY, Barton PJ, Cook SA, Mestroni L, Seidman JG, Seidman CE. Truncations of titin causing dilated cardiomyopathy. N Engl J Med. 2012;366:619-628/ PMID: 22335739

70. Welt FG, Gallegos R, Connell J, Kajstura J, D'Amario D, Kwong RY, Coelho-Filho O, Shah R, Mitchell

R, Leri A, Foley L, Anversa P, Pfeffer MA. Effect of cardiac stem cells on left-ventricular remodeling in a canine model of chronic myocardial infarction. Circ Heart Fail. 2013;6:99-106/ PMID: 23212553

71. Coelho-Filho OR, Mongeon FP, Mitchell R, Moreno H Jr, Nadruz W Jr, Kwong R, Jerosch-Herold M.

Role of transcytolemmal water-exchange in magnetic resonance measurements of diffuse myocardial fibrosis in hypertensive heart disease. Circ Cardiovasc Imaging. 2013;6:134-141

72. Nelson KH, Chatzizisis YS, Steigner ML, Mitchell RN, Blankstein R, Givertz MM. Cardiac allograft

involvement by post-transplant lymphoproliferative disorder. J Am Coll Cardiol. 2013;62: 937. PMID: 23850919

73. Zhang C, Jang S, Amadi OC, Shimizu K, Lee RT, Mitchell RN. A sensitive chemotactic assay using a

novel microfluidic device. Biomed Res International. 2013, article ID 373569 74. Coelho-Filho OR, Shah RV, Mitchell R, Neilan TG, Moreno H Jr, Simonson B, Kwong R, Rosenzweig

A, Das S, Jerosch-Herold M. Quantification of cardiomyocyte hypertrophy by cardiac magnetic resonance: implications for early cardiac remodeling. Circulation. 2013;128:1225-33. PMID: 24965024

75. Savchenko AS, Martinod K, Seidman MA, Wong SL, Borissoff JI, Piazza G, Libby P, Goldhaber SZ,

Mitchell RN, Wagner DD. Neutrophil extracellular traps form predominantly during the organizing stage of human venous thromboembolism development. J Thromb Haemost. 2014; 12: 860-870 doi: 10.1111/jth.12571/PMID: 24674135

76. Coelho-Filho OR, Shah RV, Neilan TG, Mitchell R, Moreno H Jr, Kwong R, Jerosch-Herold M. Cardiac

magnetic resonance assessment of interstitial myocardial fibrosis and cardiomyocyte hypertrophy in hypertensive mice treated with spironolactone. J Am Heart Assoc. 2014 3:e000790 doi: 10.1161/JAHA.114.000790/PMID: 24965024

77. Stone JR, Bruneval P, Angelini A, Bartoloni G, Basso C, Batoroeva L, Buja LM, Butany J, d'Amati G, Fallon JT, Gittenberger-de Groot AC, Gouveia RH, Halushka MK, Kelly KL, Kholova I, Leone O, Litovsky SH, Maleszewski JJ, Miller DV, Mitchell RN, Preston SD, Pucci A, Radio SJ, Rodriguez ER, Sheppard MN, Suvarna SK, Tan CD, Thiene G, van der Wal AC, Veinot JP. Consensus statement on surgical pathology of the aorta from the Society for Cardiovascular Pathology and the Association for European Cardiovascular Pathology: I. Inflammatory diseases. Cardiovasc Pathol. 2015; 24: 267-278 doi: 10.1016/j.carpath.2015.05.001/PMID: 26051917

78. Torre M, Hwang DH, Padera RF, Mitchell RN, VanderLaan PA. Osseous and chondromatous metaplasia in calcific aortic valve stenosis. Cardiovasc Pathol. 2016; 25:18-24. PMID: 26386747

79. Halushka MK, Angelini A, Bartoloni G, Basso C, Batoroeva L, Bruneval P, Buja LM, Butany J, d'Amati G, Fallon JT, Gallagher PJ, Gittenberger-de Groot AC, Gouveia RH, Kholova I, Kelly KL, Leone O, Litovsky SH, Maleszewski JJ, Miller DV, Mitchell RN, Preston SD, Pucci A, Radio SJ, Rodriguez ER, Sheppard MN, Stone JR, Suvarna SK, Tan CD, Thiene G, Veinot JP, van der Wal AC. Consensus statement on surgical pathology of the aorta from the Society for Cardiovascular Pathology and the Association For European Cardiovascular Pathology: II. Noninflammatory degenerative diseases - nomenclature and diagnostic criteria. Cardiovasc Pathol. 2016: 25:247-57. PMID: 27037198

80. Chu Y, Mitchell RN, Mata DA. Using exit competencies to integrate pathology into the undergraduate clinical clerkships. Hum Pathol. 2016: 47:1-3. PMID: 26482607

81. Mahadevan NR, Morgan EA, Mitchell RN. Case report and literature review: cardiac tamponade as a complication of pericardial extramedullary hematopoiesis. Cardiovasc Pathol. 2016; 25:371-374. PMID:27288747

Other peer-reviewed publications: 1. Labadie JH, Beyer CF, Harrison EH, Mitchell RN, Bowers WE. The cellular volume changes of viable

cells during mitogenic stimulation of rat lymphocytes. In: Kaplan JG, ed. The molecular basis of immune cell function. New York: Elsevier/North Holland Press, 1979: 423-8.


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2. Mitchell RN, Libby P. Cytokines as modulators of vascular disease. In: Orosz CG, Sedmak DD, and Ferguson RM, eds. Transplant vascular sclerosis. Austin, TX: R.G.Landes Co., 1995: 165-174.

3. Antman EM, Grudzien C, Mitchell RN, Sacks DB. Detection of unsuspected myocardial necrosis by

rapid bedside assay for troponin T. Am. Heart J. 1997; 133: 596-598. 4. Mitchell RN. Don’t blame the lymphocyte: Immunologic processes are NOT important in tissue valve

failure. J. Heart Valve Dis. 2001;10: 467-70. 5. Shimizu K, Mitchell RN. Chemokine-mediated recruitment of inflammatory and smooth muscle cells in

transplant-associated arteriosclerosis. Curr. Opin. Organ Transpl. 2003;8: 55-63. 6. Shimizu K, Mitchell RN. Stem cell origins of intimal cells in graft arterial disease. Curr. Athero. Rep.

2003;5: 230-237. 7. Mitchell RN. Allograft arteriopathy: pathogenesis update. Cardiovasc. Pathol. 2003;12: 1-7. 8. Lee CW, Mitchell RN, Horan RF, Castells MC. Cardiogenic shock and peripheral eosinophilia in a young

woman. Ann. Allergy Asthma Immunol. 2005;95:229-233. 9. Taqueti VR, Mitchell RN, Lichtman AH. Protecting the Pump: Controlling Myocardial Inflammatory

Responses. Annu. Rev. Physiol. 2005;68: 67-95. 10. Shimizu K, Libby P, Mitchell RN. Local cytokine environments drive aneurysm formation in allografted

aortas. Trends Cardiovasc. Med. 2005;15: 142-148. 11. Shah RV, Mitchell RN. The role of stem cells in the response to myocardial and vascular wall injury.

Cardiovasc. Pathol. 2005;14: 225-231. 12. Shimizu K, Mitchell RN, Libby P. Inflammation and cellular immune responses in abdominal aortic

aneurysms. Review. Arterioscler. Thromb. Vasc. Biol. 2006;26:987-994. 13. Mitchell RN, Libby P. Vascular remodeling in transplant vasculopathy. Circ. Res. 2007;100:967-978 14. Shimizu K, Mitchell RN. The role of chemokines in transplant graft arterial disease. Arterioscler.

Thromb. Vasc. Biol. 2008; 28:1937-49. 15. Mitchell RN. Graft Vascular Disease: Immune Response Meets the Vessel Wall. Ann. Rev. Pathol.

2009; 4:19-47. 16. Furie MB, Mitchell RN. Plaque attack: one hundred years of atherosclerosis in The American Journal

of Pathology. Am J Pathol. 2012;180:2184-2187. 17. Mitchell RN. Learning from rejection: What transplantation teaches us about (other) vascular

pathologies. J Autoimmun. 2013; 45:80-89. Non-peer reviewed scientific and medical publications: 1. Mitchell RN, Abbas AK. Processing and presentation of antigens by B lymphocytes--a commentary.

J. Molec. Cell. Immunol. 1989; 4:189-190. 2. Mitchell RN. Chapter 4, Immunity; Chapter 7, Blood Vessels; Chapter 8, The Heart; Chapter 18, The

Skin. In: Robbins SL, Cotran RS, Kumar V, eds. Pocket companion to Robbins Pathologic Basis of Disease. Philadelphia: WB Saunders, 1991: 46-75, 125-139, 140-165, 411-430.

3. Mitchell RN, Wolf MA. Case Studies, Pathology Refresher. In: Braunwald E, Rose BD, eds.

Intensive review of internal medicine, fourth edition. Boston: The Nimrod Press, 1993: 525-542. 4. Mitchell RN. Chapter 20, The Skin. In: Robbins SL, Cotran RS, Kumar V, eds. Pocket companion to

Robbins Pathologic Basis of Disease, 2nd Ed. Philadelphia: WB Saunders, 1995: 458-477. 5. Mitchell RN, Cotran RS. Chapter 1: Cell Injury, Death, and Adaptation; Chapter 2: Acute and Chronic

Inflammation; Chapter 3: Repair: Cell Regeneration, Fibrosis, and Wound Healing; and Chapter 4:


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Hemodynamic Disorders, Thrombosis, and Shock. In: Kumar V, Cotran RS, Robbins SL, eds. Basic Pathology, 6th Ed. Philadelphia: WB Saunders, 1997.

6. Libby P, Mitchell RN. Cytokines score a knock-out: Harnessing gene targeting to gain insight into the

pathogenesis of myocarditis. Circulation 1997; 95:551-552. 7. Mitchell RN, Cotran RS. Chapter 5: Hemodynamic Disorders, Thrombosis, and Shock. In: Cotran RS,

Kumar V, Collins TC, eds. Robbins’ Pathologic Basis of Disease, 6th Ed. Philadelphia: WB Saunders, 1998.

8. Mitchell RN. Chapter 5: Hemodynamic Disorders, Thrombosis, and Shock; Chapter 18, The Skin. In:

Robbins SL, Cotran RS, Kumar V, Collins T, eds. Pocket companion to Robbins’ Pathologic Basis of Disease, 3rd Ed. Philadelphia: WB Saunders, 1999.

9. Mitchell RN. Murine Heterotopic Model of Transplant Arteriopathy. In: Simon DI, Rogers C, eds.

Chapter 16: Vascular Disease and Injury: Preclinical Research. Totowa, NJ: Humana Press, 2000. 10. Mitchell RN, Abbas AK. Chapter 15: Cytokines Regulating Immune Inflammation; Interleukin-4,

Interleukin-10, and Interleukin-12. In: Austen G, Burakoff S, Strom T, Rosen F, eds. Therapeutic Immunology, 2nd Ed. Malden, MA: Blackwell Science, 2000.

11. Mitchell RN, Cotran RS. Chapter 1: Cell Injury, Adaptation and Death; Chapter 2: Acute and Chronic

Inflammation; Chapter 3: Repair: Cell Regeneration and Fibrosis; and Chapter 4: Hemodynamic Disorders, Thrombosis, and Shock. In: Kumar V, Cotran RS, Robbins SL, eds. Basic Pathology, 7th Ed. Philadelphia: WB Saunders, 2003.

12. Mitchell RN, Kumar V. Chapter 5: Diseases of Immunity. In: Kumar V, Cotran RS, Robbins SL, eds.

Basic Pathology, 7th Ed. Philadelphia: WB Saunders, 2003. 13. Mitchell RN, Cotran RS. Chapter 5: Hemodynamic Disorders, Thrombosis, and Shock. In: Kumar V,

Abbas AK, Fausto N, eds. Robbins and Cotran Pathologic Basis of Disease, 7th Ed. Philadelphia: Elsevier Saunders, 2004.

14. Mitchell RN, Schoen FJ. Chapter 3.3: Cells and Cell Injury. In: Rattner BD, Hoffman AS, Schoen FJ,

Lemons JE, eds. Biomaterials Science, 2nd Ed. San Diego: Elsevier Academic Press, 2004. 15. Schoen FJ, Mitchell RN. Chapter 3.4: Tissues, the extracellular matrix, and cell-biomaterials

interactions. In: Rattner BD, Hoffman AS, Schoen FJ, Lemons JE, eds. Biomaterials Science, 2nd Ed. San Diego: Elsevier Academic Press, 2004.

16. Mitchell RN. Chapter 4.3: Innate and adaptive immunity: The immune response to foreign materials.

In: Rattner BD, Hoffman AS, Schoen FJ, Lemons JE, eds. Biomaterials Science, 2nd Ed. San Diego: Elsevier Academic Press, 2004.

17. Mitchell RN, Lichtman AH. The link between IFN-γ and allograft arteriopathy: is the answer NO? J.

Clin. Invest. 2004; 114:762-764. 18. Mitchell RN (editor), Kumar V, Abbas AK, Fausto N, eds. Pocket companion to Robbins and Cotran

Pathologic Basis of Disease, 7th Ed. Philadelphia: Saunders Elsevier, 2006. 19. Shimizu K, Mitchell RN. Allograft arteriopathy: Heterotopic heart transplantation and aortic

interposition grafts. In: Xu, Q, ed. A handbook of mouse models of cardiovascular disease. West Sussex, England: John Wiley and Sons, Ltd., 2006.

20. Kumar V, Abbas AK, Fausto N, Mitchell RN (editor), eds. Robbins Basic Pathology, 8th Ed.

Philadelphia: Saunders Elsevier, 2007. 21. Winters GL, Mitchell RN. Pathology of Cardiac Transplantation. In: McManus BM, Braunwald E, eds.

Atlas of Cardiovascular Pathology, 2nd Ed. Philadelphia: Springer Science, 2008. 22. Mitchell RN. Chapter 4: Hemodynamic Disorders, Thromboembolic Disease, and Shock. In: Kumar V,

Abbas AK, Fausto N, Aster, J, eds. Robbins and Cotran Pathologic Basis of Disease, 8th Ed. Philadelphia: Elsevier Saunders, 2009.

23. Mitchell RN, Schoen FJ. Chapter 11: Blood Vessels. In: Kumar V, Abbas AK, Fausto N, Aster, J, eds.

Robbins and Cotran Pathologic Basis of Disease, 8th Ed. Philadelphia: Elsevier Saunders, 2009.


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24. Schoen FJ, Mitchell RN. Chapter 12: The Heart. In: Kumar V, Abbas AK, Fausto N, Aster, J, eds. Robbins and Cotran Pathologic Basis of Disease, 8th Ed. Philadelphia: Elsevier Saunders, 2009.

25. Klatt EC, Mitchell RN (editor/author). Robbins and Cotran Pathology Flash Cards: Philadelphia:

Elsevier Saunders, 2010. 26. Mitchell RN (editor), Kumar V, Abbas AK, Fausto N, Aster JC, eds. Pocket Companion to Robbins

and Cotran Pathologic Basis of Disease, 8th Ed. Philadelphia: Elsevier Saunders, 2012. 27. Seidman MA, Mitchell RN. Surgical pathology of small- and medium-sized vessels. In: Winters GL, ed.

Surgical Pathology Clinics: Current Concepts in Cardiovascular Pathology. Philadelphia: Saunders, 2012.

28. Mitchell RN, Schoen FJ. Chapter II.1.4: Cell function and response to injury. In: Rattner BD, Hoffman

AS, Schoen FJ, Lemons JE, eds. Biomaterials Science, 3rd Ed. San Diego: Elsevier Academic Press, 2013.

29. Schoen FJ, Mitchell RN. Chapter II.1.5: Tissues, the extracellular matrix, and cell-biomaterial

interactions. In: Rattner BD, Hoffman AS, Schoen FJ, Lemons JE, eds. Biomaterials Science, 3rd Ed. San Diego: Elsevier Academic Press, 2013.

30. Mitchell RN. Chapter II.2.3: Innate and adaptive immunity: The immune response to foreign materials.

In: Rattner BD, Hoffman AS, Schoen FJ, Lemons JE, eds. Biomaterials Science, 3rd Ed. San Diego: Elsevier Academic Press, 2013.

31. Seidman MA, Mitchell RN, Stone JR. Chapter 12: Pathophysiology of Atherosclerosis. In: Willis MS,

Homeister JW, Stone JR, eds. Cellular and Molecular Pathobiology of Cardiovascular Disease. San Diego: Elsevier Academic Press, 2014.

32. Mitchell RN. Chapter 1: The Cell as a Unit of Health and Disease. In: Kumar V, Abbas AK, Aster, J,

eds. Robbins and Cotran Pathologic Basis of Disease, 9th Ed. Philadelphia: Elsevier Saunders, 2014 33. Mitchell RN. Chapter 11: Blood Vessels. In: Kumar V, Abbas AK, Aster, J, eds. Robbins and Cotran

Pathologic Basis of Disease, 9th Ed. Philadelphia: Elsevier Saunders, 2014 34. Schoen FJ, Mitchell RN. Chapter 12: The Heart. In: Kumar V, Abbas AK, Aster, J, eds. Robbins and

Cotran Pathologic Basis of Disease, 9th Ed. Philadelphia: Elsevier Saunders, 2014 35. Mcmanus, LM, Mitchell RN., eds. Pathobiology of Human Disease, Elsevier, 2014 36. Seidman, MA, Mitchell RN. Chapter 6: Fundamental Principles in Cardiovascular Genetics. In: Buja,

LM, Butany J, eds. Cardiovascular Pathology, 4th Ed. Elsevier, 2016 37. Klatt EC, Mitchell RN (editor/author). Robbins and Cotran Pathology Flash Cards, 2nd Ed.,

Philadelphia: Elsevier Saunders, 2016. 38. Mitchell RN (editor), Kumar V, Abbas AK, Fausto N, Aster JC, eds. Pocket Companion to Robbins

and Cotran Pathologic Basis of Disease, 9th Ed. Philadelphia: Elsevier Saunders, 2016. Professional Educational Materials or Reports, in print or other media: 1. HST030 Human Pathology Course at Harvard Medical School: 1999-present • Syllabus development, organization, and preparation (10 lectures, full notes and PowerPoints);

problem sets and answers (4 total); clinical-pathologic cases and answers (10 total); laboratory manual (22 labs); examinations and answers (3 each year). Updated annually.

• The intended audience is medical and graduate students in the Harvard-MIT Division of Health Sciences and Technology (HST).

• The material forms the basis for the teaching of the core semester-long Human Pathology course in HST.

2. HST146 Human Biochemistry and Metabolic Disease: 2009-present • Syllabus development and organization, and examinations and answers (1 each year), updated

annually. • The intended audience is medical and graduate students in the Harvard-MIT Division of Health

Sciences and Technology (HST).


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• The material forms the basis for the teaching of the core month-long Human Biochemistry course in HST.

3. American Society of Investigative Pathologist (ASIP) Summer Academy-Molecular Mechanisms

of Human Disease: Injury, Inflammation, and Tissue Repair: 2008 and 2010 • Syllabus development, organization, and preparation (1 lecture on atherosclerosis) • The intended audience is biomedically-oriented graduate students, post-doctoral fellows, junior

research faculty, industrial researchers, and faculty involved in teaching pathology. • The material forms the basis for teaching a 3-day fundamentals and frontiers course in basic

pathobiology for a national and international audience. 4. Society of Cardiovascular Pathology Companion Meeting at the US and Canadian Association

of Pathologists: 2010-2013 • Syllabus development and organization. Topics change annually; 2010 involved the cardiovascular

pathology of genetic disorders. • The intended audience is pathology residents and fellows, and academic practicing pathologists. • The material forms the basis for a half-day of frontiers seminars in cardiovascular pathology for a

national and international audience. Thesis: 1. Mitchell RN. Doctoral thesis: rat lymphocyte surface glycoproteins mediating mitogenesis by

periodate or neuraminidase plus galactose oxidase. New York: The Rockefeller University Press, 1980.


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Narrative Report My academic endeavors encompass several different activities, with core emphases on medical education, as well as clinical and research aspects of cardiovascular pathology. Approximately 10-15% of my overall effort relates to clinical responsibilities in Cardiovascular Surgical Pathology and Autopsy Pathology. Another 15-20% is focused on medical education, teaching in several venues at Harvard Medical School and materially contributing to several medical textbooks and educational materials. As the Associate Master and Associate Director of the combined Harvard-MIT Division of Health Sciences and Technology at Harvard Medical School, I have primary responsibility for its educational mission, as well as the mentoring and advising of its MD, MD/PhD, and PhD students; this activity occupies another 10-15% of my effort. Finally, in addition to ongoing collaborations in stem cell biology and imaging with a number of BWH cardiologists, I have my own research focus involving the mechanisms underlying solid organ allograft rejection, with a specific emphasis on the pathways leading to allograft arteriopathy. Area of Excellence-Teaching and Educational Leadership In addition to my core Human Pathology, and Biochemistry teaching/directing responsibilities in the Harvard-MIT Health Sciences and Technology (HST) program (directed continuously for over a decade), I regularly participate with both lectures and laboratory teaching in other HST courses including immunology, anatomy, and cardiovascular pathophysiology. I also give lectures in the HMS New Pathway curriculum (Immunology, Microbiology, and Pathology), and have been recognized with six teaching awards during my tenure at Harvard Medical School, both within HST and more broadly within the medical school. Besides HMS classroom teaching, I also chair the HST MD Curriculum Committee, and have been active in ongoing curriculum reform throughout the medical school. On the national level, I am a past Chair of the Education Committee , and current Chair of Programming for the American Society of Investigative Pathology have developed an on-line teaching initiative. In my role with the ASIP, I also developed and currently direct the annual ASIP Summer Academy, teaching fundamentals of acute and chronic inflammation and wound healing to graduate students, fellows, junior and senior faculty, and scientists in industry. Besides my ongoing teaching responsibilities, I have written the Cellular Basis of Disease, Thrombosis, Blood Vessel, and Heart chapters for Robbins and Cotran Pathologic Basis of Disease, and am one of the editors (authoring several chapters) for Robbins Basic Pathology and the Pocket Companion to Robbins and Cotran Pathologic Basis of Disease. More recently, in association with Dr. Ed Klatt, a new teaching modality for the Robbins family of pathology texts, the Pathology Flash Card series was developed. Finally, I am Editor-in-Chief (with Dr. Linda McManus) of an innovative e-book for Elsevier: Pathobiology of Human Disease. Investigation

My major research emphasis is on the mechanisms of acute allograft rejection and transplant-associated arteriosclerosis. The work uses murine aortic and cardiac allograft models, taking advantage of mouse strains with targeted deletions of various cytokines, chemokines, or their receptors to examine the roles of selected mediators, co-stimulatory molecules, and therapeutic agents in the development of acute and chronic allograft rejection. The work has shown that circulating bone marrow-derived precursors contribute to allograft arteriopathy, as well as in more typical atherosclerosis and other vascular pathologies, and has also demonstrated that different cytokine milieus lead to either stenosing vascular lesions (Th1 cytokines) or to aneurysm formation (Th2 cytokines).

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