Hazard awareness

Download Hazard awareness

Post on 20-Jan-2015

724 views

Category:

Health & Medicine

1 download

Embed Size (px)

DESCRIPTION

 

TRANSCRIPT

<ul><li> 1. Session 3 Laboratory Safety TrainingChemical Risk Management </li> <li> 2. Toxic effects of LaboratoryChemicals In order to minimize the hazards associated with chemicals used in the laboratory the researcher must investigate many sources of information to safely design the experiment. There are many ways to do this. The starting point should be with a review of the MSDS. 2 </li> <li> 3. Hazard Communication Hazard Communication Standard 29CFR 1910.1200 OSHA published in 1988, requires, chemical manufacturers or importers to evaluate the hazards of the products they supply and summarize this information on Material Safety Data Sheets (MSDS), shipping labels, and product warnings 3 </li> <li> 4. Hazard Communication Employers must supply this information to their employees and provide training on: The chemical hazards found in their work place. This includes training on reading hazard labels and MSDS, physical and health hazards of the chemicals, how to detect releases, the use of any required personal protective equipment (PPE), and the details of the hazard communication program. 4 </li> <li> 5. Hazard Communication Specific laboratory requirements include: Ensuring all incoming chemical containers are labeled, MSDS are received with incoming chemicals and are readily accessible to laboratory employees at all times, while working in their labs, Ensure all laboratory, employees are trained on the physical and health hazards associated with the chemicals used including: 5 </li> <li> 6. Hazard Communication Methods and observations that may be used to detect the presence or release hazardous chemicals in the work area, The measures employees can take to protect themselves from chemical hazards, such as work practices, emergency procedures, and PPE. 6 </li> <li> 7. Hazard Communication Laboratories that ship hazardous chemicals are considered either a chemical manufacturer or distributor under this standard and must also comply with the shipping requirements, including labeling containers, using proper shipping names and preparing an MSDS to be provided to the recipients 7 </li> <li> 8. Each MSDS must contain thefollowing information:1. Suppliers name, 1. Physical hazards, address, ph #, date, including reactivity,2. Chemical name, CAS 2. Health hazards, # of all hazardous including signs and ingredients if it is &gt; 1% symptoms of of the product, exposure, medical3. Physical and chemical conditions that characteristics, vp., fp., might be aggravated by exposure, 8 </li> <li> 9. Each MSDS must contain thefollowing information:1. Primary routes of 1. Emergency and first entry, aid procedures,2. PELs, RELs, TLVs 2. Disposal3. Toxicity data, considerations4. Storage and 3. Transportation handling data, information 9 </li> <li> 10. Additional sources of hazardinformation National Fire Protection Association NFPA 704 National Institute of Occupational Safety and Health (NIOSH) RELs. American Council of Governmental Hygienists (ACGIH) TLVs International Agency for Cancer Research, (IARC) 10 </li> <li> 11. Additional sources of hazardinformation National library of Medicine (NLM) Toxline, Medline Hazardous substance Data Base (HSDB) Registry of Toxic Effects of Chemical Substances (RTECS) MSDS database e.g. SIRI http://www.SIRI.org 11 </li> <li> 12. Other hazard classification systems The NFPA 704 System is a means of providing hazard information for a material. Each of the four sections is associated with a particular hazard and the higher the number the more hazardous the material is for that particular characteristic. The fourth section is to give information on special hazards. Next are the four sections and an explanation of each. 12 </li> <li> 13. Red=Flammability 4-Materials with a flashpoint below 73 F (22 C) and a boiling point below 100 F. 3-Materials with a flashpoint below 73 F and a boiling point greater than or equal to 100 F (38 C) or a flashpoint above 73 F and less than 100 F. 2-Materials with a flashpoint above 100 F, but not exceeding 200 F (93.3 C). 1-Materials with a flashpoint above 200 F. 0-Materials which normally wont burn. 13 </li> <li> 14. Blue-Health Hazard 4-Materials with an oral LD50 of less than or equal to 5 mg/ kg. 3-Materials with an oral LD50 above 5, but less than 50 mg/ kg. 2-Materials with an oral LD50 above 50, but less than 500 mg/kg. 1-Materials with an oral LD50 above 500, but less than 2000mg/kg. 0-Materials with an oral LD50 above 2000mg/kg. 14 </li> <li> 15. Yellow=Reactivity Hazard4-Material is capable of explosion or detonation atnormal temperature and pressure.3-Material is capable of explosion, but requires astrong initiating source, or the material reactswith water.2-Material undergoes violent chemical changes atelevated temperature and pressure.1-Normally stable, but can become unstable atelevated temperatures.0-Normally stable. 15 </li> <li> 16. White = Special HazardW Water ReactiveOx OxidizerCOR CorrosiveRadiation 16 </li> <li> 17. Routes of Exposure Inhalation - Most common route of exposure, lungs are designed for maximum transport and adsorption of vapors, large surface area (1000 sf) Dermal Second most common route of exposure, lipid (pass with greater ease) and water soluble chemicals can pass through the skin. Has 20 sf surface area. 17 </li> <li> 18. Routes of Exposure Ingestion can occur through food contamination, eating drinking in lab, poor hygiene, mucociliary transport of vapors trapped in upper air ways, Injection Can occur through injury and needle sticks 18 </li> <li> 19. Lethal Concentration Lethal Concentration- LC-50, pertains to inhalation hazards. It is the concentration of a material in air that will kill 50% of the test subjects when administered as a single exposure (typically 1 to 4 hours). This value gives you an idea of the relative toxicity of the material. This value applies to vapors, dusts, mists and gases. 19 </li> <li> 20. Lethal Dose An LD50 value is the amount of a solid or liquid material that it takes to kill 50% of test animals in one dose. The dose may be administered orally (by mouth), or injection into various parts of the body. The value is usually reported along with the administration method. 20 </li> <li> 21. Acute Toxicity Levels Toxicity LD-50 LD-50(rab LC- 50 Probable lethal human (rats) bits) (rats) dose Extremely</li></ul>