healing skin safely - mediwales€¦ · • unlike current products, healing skin safely &...
TRANSCRIPT
TM
healing skin safely
27thApril2016
…..with natural ingredients
DrNeilK.GibbsChiefTechnologyOfficer
‘CurapelisaWales-basedhealthcarecompanythatresearches,patentsanddemonstratestheclinical
efficacyofinnovaIveproductscontainingsafe(GRAS)&naturallyoccurringacIvesthat
forthebenefitofpaIents,ourcustomersandourshareholders’
TM
heal skin safely
• SpunoutoftheUniversityofManchesterin2014
• >£1.2millioninvestmentfromFinanceWales,LancasterCapital&
ResearchCouncilgrants
• Experiencedmanagementteam
• BasedintheLifeSciencesHubWales
• Alltechnologiesbasedonnaturallyoccurring,safe(GRAS)acIves
• Por]olioof20patentsover3families
• Advancedprogrammeofpre-clinicalandclinicalstudies
Company Highlights TM
Safe,NaturalOralProductforEczema• 47millionpaIentsacross7majormarkets;20%ofchildren• >US$3.8bnmarketexpanding>10%CAGR
Safe,NaturalCosmeIcforLightening&AnI-ageing• India,China&Japandominate• >US$19bnmarketincreasing>13%CAGR
Safe,NaturalTopicalProductforPsoriasis• 18millionpaIentsacross7majormarkets• >$2.9bnmarketexpanding>15%CAGR
Lead Product Portfolio
HISTIMEX
MELIDEX
OLIDEX
Safety of Current Eczema Treatments
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CommercialinConfidence
Topicalcor*costeroids(skinthinning,bruising,discoloraIon,telangiectasia,delayedwoundhealing,contactdermaIIs,Cushing'sdisease,femoralheadosteonecrosisandcataracts;‘steroidphobia’)• Topicalcalcineurininhibitors(suppressimmunesystem,BlackBoxwarning;cancerrisk)
• Immunosuppressants(suppressimmunesystem;skincancerandlymphomarisk)
• Phototherapy(UVBskincancerrisk)• Oralan*histamines(?efficacy;notforchildren)• Alitre*noin(teratogenic,photosensiIser)
HISTIMEX
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“There is a gap in the market for companies to develop safer systemic
therapies for atopic dermatitis…….”
Business Insight “The Dermatology Market Outlook”
Datamonitor report DMHC2279
Market Research with
HISTIMEX
• Natural,safe,GRASacIve–extractedfromegsoybeans• TargetsdefecIveskinbarrierbyenhancingfilaggrin• PoCstudyinadultsindicatesclinicaleffecIveness• IndicaIons:Adultandpaediatric(atopic)eczema• AdministraIon:Onceadayoral
A Safe, Natural Oral Product for Eczema
HISTIMEX
HISTIMEX Placebo
** **
• Randomised,doubleblind,placebocontrolledstudy*• 24adultAtopicDermaIIs(AD)paIents• Clinician(SCORAD)andpaIent(POEM)ADdiseasescores
** **
Safe & Effective in Eczema
c40%ECZEMA
IMPROVEMENT
40% IMPROVEMENT
*Gibbs & Griffiths, J Invest Dermatol, 2012, 132, S51
HISTIMEX
HISTIMEX Routes to Market
RISK
• Natural,GRASacIve–extractedfromchicory• Targetsskincell(keraInocyte)proliferaIon,reducingKi67andenhancingTUNEL
• Pre-clinicalefficacy;currentlyinPoCclinicalstudy• IndicaIons:adultmild-moderatepsoriasis• AdministraIon:topicalcream
OLIDEX A Safe, Natural Topical Product for Psoriasis
• Natural, safe, GRAS active - extracted from eg sugar beet.
• Reduces pigmentation (tyrosinase) and inflammatory interleukin-8
• Indications: Skin lightening, age spots, melasma • Administration: topical cosmetic
A Safe Lightening Anti-ageing Cosmetic
MELIDEX
• Unlikecurrentproducts,HealingSkinSafely&Naturally
• Addressinglargemarkets&unmetclinicalneed
• Allproductsbasedonnaturallyoccurring,safe(GRAS)acIves
• StrongscienceandexpansiveIP
• RapidclinicalvalidaIon&riskmiIgaIon
• ApplicaIonsacrosshealthcare,pharma&cosmeIcsectors
• AcIvelyseekinglicensees/partnersforleadtechnologies
Summary
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