1HEALTH TECNALIA I INSPIRING BUSINESS

Health www.tecnalia.com

We are committed to one of the future's greatest challenges: to improve the quality of people's lives, particularly in terms of ageing.

2THIS IS US,THIS IS TECNALIA

Inspiring Business

VALUES

IDEAS THAT CREATE VALUE

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COMMITMENT TOTHE FUTURE

BUSINESS PERSPECTIVE

RESEARCH TENACITY

EFFICIENTCREATIVITY

FLEXIBILITY

CONNECTIVITY

SALESNETWORK

ASSOCIATED INNOVATION CENTRES

BRANCHES ABROAD

ALLIANCES

HEADQUARTERS

TECNALIA Research & Innovation is the first privately funded applied research centre in Spain and one of the leading such centres in Europe. A combination of technology, tenacity, efficiency, courage and imagination.

We identify and develop business opportunities through applied research. Inspiring Business is a different, unique vision: we visualise ideas that generate value and provide creative technological solutions to produce real results.

INTERNATIONAL PRESENCE

7 BUSINESS DIVISIONS

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SUSTAINABLE CONSTRUCTION

ENERGY AND ENVIRONMENT

ICT-EUROPEANSOFTWARE INSTITUTE

INDUSTRYAND TRANSPORT

HEALTH

TECHNOLOGICAL SERVICES

INNOVATION STRATEGIES

3HEALTH TECNALIA I INSPIRING BUSINESS

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TECHNOLOGICAL SERVICES

VENTURES

R&D PROJECTS

BUSINESS

INSP

IRIN

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ONE HUNDRED AND TEN

WORKING TOWARDS A COMMON GOAL:

1stOUR ACTIVITY IN FIGURES

EXPERTS ON STAFF

MILLION EUROS INCOME

At TECNALIA we are organised in 7 fully interconnected Business Divisions. Cooperation works thanks to the transversality of teams, projects and clients collaborating with each other, combining expertise and commitment. Our best asset is our team, made up of more than 1,500 experts who work to transform knowledge into GDP in order to improve people's quality of life by generating business opportunities for companies.We are committed to the future, society, our planet and our environment. This responsibility provides focus to our values and reinforces our activities.

TECNALIA transforms Knowledge into GDP to improve people's quality of life by generating business opportunities for Companies"

DOCUMENT PUBLISHED IN NOVEMBER 2013

TO GENERATE BUSINESS OPPORTUNITIESTHROUGH APPLIED RESEARCH.

4 APPROACHES TOTHE WAY WE WORKWITH COMPANIES

YOUR PROJECT

FIRST SPANISH PRIVATE ORGANISATION IN FINANCIAL RETURN, PROJECTS APPROVED AND LED WITHIN THE EC 7FP

TECHNOLOGY AND INNOVATION STRATEGY

1,500

Health

TECNALIA carries out health-related activities regarding ageing in order to improve the quality of life of the elderly. Our international and multi-disciplinary team is made up by 130 researchers specialised in the fields of health-oriented biotechnology, biomaterials, robotics and ICTs; this allows us to provide solutions to many health challenges from different perspectives such as health-care, food or medical devices, among others.

We are certain that today's innovation has to be open.

Therefore, we connect with international knowledge centres and people around the world to expedite our research processes and increase our results.

This operating scheme has led us to achieve a turnover of 8 million euros, create 7 technology-based companies and register 18 patents. Transversality and the multi-disciplinary nature of the business areas of our Health Division give due response to the technological challenges that require global and highly-specialised solutions.

OUR OFFER

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ACCESSIBLE SOLUTIONS FOR INTERACTION

SUPPORT SOLUTIONS FOR COGNITIVE DISABILITY

03. E-Health

01.Rehabilitation

03. eHealth

05. Biomaterials

NEUROREHABILITATION

ORTHOPAEDIC REHABILITATION

TELECARE

TELEHEALTH

MHEALTH

DEVICES & MATERIALS FOR "IN VIVO" APPLICATIONS

BIOLOGICAL ASSESSMENT

"IN VITRO" DIAGNOSTIC DEVICES AND CELL-BASED TESTS

02. AssistiveTechnologies

04. Bioprocesses &Preservation NEW FOODS

PRESERVATION

OENOLOGY

5HEALTH TECNALIA I INSPIRING BUSINESS

"We are decisively committed to gaining private capital from health-care companies or from other sectors seeking to diversify their strategy".

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We create value for businesses and society at large, acquiring, generating and transferring knowledge in the health and welfare fields.

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7HEALTH TECNALIA I INSPIRING BUSINESS

Our Offer

Neurorehabilitation /

Rehabilitation robotics and functional electrical stimulation for physical training and motor learning.

Tools for the quantitative assessment of functional improvement.

Technologies enabling tele- rehabilitation.

New methods for assessing motor and cognitive learning and training in terms of neuronal changes.

Orthopaedic rehabilitation /

Technologies that promote the recovery from muscular/skeletal injuries and reduce and/or compensate any functional impairment.

Smart materials for functional support or recovery.

Detection and response to biosignals.

REHABILITATION 01.

ELECTRICAL FUNCTIONAL STIMULATION (EFS) FOR PATIENTS WITH PARALYSED MUSCLES.

TECNALIA HAS DEVELOPED FESARRAY, an advanced technology which provides selective neuromuscular electric stimulation for electric therapies, with a function to compensate for the lack of movement in patients with paralysed muscles.

FESArray is applied directly on to the skin and does not require surgery. It can be used discreetly under any kind of clothing. The great news in relation with other electrical stimulation systems is the implementation of a unique multi-pad electrode array.

TECNALIA offers its customers the chance to:

Buy a license.

Agree on a shared-risk joint venture.

8Our Offer

Accessible solutions for interaction /

Support products for people with auditory and visual disabilities.

Interfaces, systems and devices that improve the communication of the elderly an/or people with functional diversities.

AAL (Ambient Assisted Living) solutions for the home, workplace and life in general.

Robotics for manipulation and haptic technologies.

Assistive solutions for cognitive disability /

Systems to assist or help people with a cognitive disability to undertake day- to-day activities.

Cognitive training.

Multi-sensorial education at home and in the workplace.

SOUND RECOGNITION SYSTEM.

TECNALIA has developed a system which, by analysing the signal captured by a microphone placed in a home, automatically recognises the sounds that may occur in the environment (such as doorbells, running taps, mobile phones, etc.).

This can be used in various ways:

Support for people with impaired hearing: this technology can provide support in emergency situations or in daily situations that require their attention (banging on the door, a fire, the shower tap, an alarm clock, etc.).

Support for telecare or telemonitoring systems: home sounds recognition could be used by expert systems for monitoring activities. This information may be used by health care providers or caregivers, with the purpose of detecting any possible age- related cognitive impairment, or by applications offering a range of services to the user.

TECNALIA offers its customers the chance to:

Buy a license.

Agree on a shared-risk joint venture.

ASSISTIVE TECHNOLOGIES02.

9HEALTH TECNALIA I INSPIRING BUSINESS

Telecare /

Service platforms and advanced solutions for an integrated social and health care.

Remote monitoring of people's behaviour at home.

Early preventive detection of behavioural changes.

Telehealth /

Remote monitoring of vital signs.

Home-based solutions for chronic diseases.

Compliance with pharmacological treatment.

mHealth /

Personalised healthcare applications.

New approaches in healthcare.

eHEALTH 03.

We develop accessible, easy-to-use assets for the elderly and/or for those with functional diversity.

FEELING DETECTION SYSTEM.

TECNALIA has developed SENTIENT, a system that can detect whether a person is experiencing a positive or negative emotion, and measure its intensity, using a standard pulse meter and a smartphone.

SENTIENT can be used for various purposes, such as:

HEALTH. In the case of people with severe difficulties in expressing their emotions, for instance, those with autistic spectrum disorders or in a dependency status, this system can help them interpret their emotional status and prevent situations that could be potentially harmful or dangerous. SOCIETY. This system can be used as a personal stress manager.

POLITICS. It provides campaign managers with the necessary information to determine, adjust or even promote the elements influencing voters' intentions.

ADVERTISING. This can help measuring the emotional response to advertising spots to optimise the investment in promotional campaigns.

TECNALIA offers its customersthe opportunity to:

Buy a license.

Agree on a shared-risk joint venture.

Sub-hiring services for marketing and advertising.

OENOLOGY

The transversal nature of our technologies allows us to provide solutions for the Spanish wine industry as well as those in prestigious European regions such as France, Italy and Portugal.

Innovative technologies to improve food quality and safety.

Isolation, selection and immobilisation of indigenous wine yeasts.

New technologies for optimisation of the production stages.

Analytical methods and analysis of specific compounds in grape, wine and associated materials.

By-product valorisation.

BIOPROCESSES & CONSERVATION04.

We work intensely in the food sector and related industries with the purpose of developing innovative foods, new preservation methods and a competitive wine industry.

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NEW FOODS

We develop products in response to the needs of specific sectors of the population.

Healthier and/or functional foods.

Bioactive compounds.

Protection, addition and control of the release of bioactive compounds.

Micro- and nanoencapsulation of ingredients.

Biotechnological processes.

In vitro testing for the ingredient monitoring.

Bioactivity studies on functional compounds.

Identification and quantification of new chemical pollutants.

PRESERVATION

Production of edible/biodegradable films and coatings.

Mixture and modification of biopolymers. Production and incorporation of bio-nanoscaffolds.

Physicochemical and functional characterisation of biomaterials.

Active antimicrobial/antioxidant packaging system.

Smart packaging systems.

ACTIVE PACKAGING SYSTEM.

TECNALIA has developed an active packaging system that improves food preservation, extending their useful life.

An extension of the useful life by up to 15% has been achieved in certain foods. It can provide coverage to more distant markets, to compete with products based on natural compounds and free of chemicals that might affect their composition. Therefore, it is a commitment to natural foods that will help businesses to meet their consumers' demands, who are increasingly aware and prefer to buy healthy products.

TECNALIA offers its customers the chance to:

Buy a license.

Agree on a shared-risk joint venture.

MICROENCAPSULATED SYMBIOTIC MATERIAL.

TECNALIA has developed an encapsulated product that includes probiotic and prebiotic compounds and polymeric materials as encapsulating elements.

The structure of the capsule makes it possible to create a symbiotic agent that is able to reach the intestinal tract in a more efficient form than non-encapsulated symbiotics. Accordingly, this encapsulated material, whether alone or incorporated into foods, can be used to prevent intestinal tract dysfunction.

TECNALIA offers its customers the chance to:

Buy a license.

Agree on a shared-risk joint venture.

Collaboration agreement for the development of new ingredients.

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HEALTH TECNALIA I INSPIRING BUSINESS

Our Offer

Devices and materials for "in vivo" applications /

Biodegradable matrices for tissue regeneration.

Non-degradable materials for bone implants with controlled porosity.

Functionalisation of device surfaces through click chemistry and carbodiimide chemistry.

Biodegradable materials for advanced therapies (polymeric coatings and nanoparticles for supplying medicines and injectable hydrogels for cell therapy).

Biological Assessment /

CE marking, certification of standard ISO 10993.

Characterisation of the biological impact for new materials and products.

Nano-safety: biological impact assessment for nanomaterials (cell consumption, mutagenicity, pro- inflammatory action, etc.).

"In vitro" diagnostic devices and cell-based tests /

Materials and technologies that allow 3D in vitro cell culture.

Customised consumable-based polystyrene design.

Carbon nanotubes with integrated biosensors.

BIOMATERIALS05.

PEEK POROUS MATERIAL FOR BONE IMPLANTS.

TECNALIA has developed processes which synthetise PEEK (polyetheretherketone) porous structures and functionalise their surface with biological molecules (such as RGD peptides).

These characteristics make the TECNALIA produced materials different from other PEEK materials in the market, providing a unique means towards the maximum osseointegration, bone conduction and induction of PEEK implants. At the same time, TECNALIA has registered these processes and is entirely free to work on an client-oriented optimisation of the resulting PEEK materials.

TECNALIA offers its customers the chance to:

Buy a license.

Sign an agreement for future co- development and exploitation.

TECNALIAParque Cientfico y Tecnolgico de BizkaiaC/ Geldo, Edificio 700E-48160 Derio-Bizkaia (Spain)

T 902 760 000*T +34 946 430 850 (International calls)www.tecnalia.com

IGNACIO MANZANARESDirectorignacio.manzanares@tecnalia.com

JOS MIGUEL AZKOITIABusiness Development Directorjosemiguel.azkoitia@tecnalia.com

JAVIER GONZLEZ LODOSOMarket Directorjavier.gonzalez@tecnalia.com

HEALTH DIVISIONwww.tecnalia.com/health/salud@tecnalia.com