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hemoglobin · 2009. 4. 28. · 2.8 26 oxygen y02 veins 0.91 0.55 binding 1.00 myoglobin 0.80 0.30...

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  • hemoglobin · 2009. 4. 28. · 2.8 26 Oxygen Y02 Veins 0.91 0.55 Binding 1.00 Myoglobin 0.80 0.30 0,40 0.20 Venous pressure Hemoglobin in whole blood Arterial prcssurc 80 100 120
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    Biochemical adaptation: mechanism and process in

    physiological evolution

    Peter W. Hochachka, George N. Somero

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    Frequency in the population

    HbS hetero ~ 25% of Africans

    !p =pq[p(wAA " wAa ) + q(wAa " waa )]

    w

    For wAA>wAa>waa stable solutions p=1 and p=0

    Other stable solutions arise if wAa>waa wAa>wAA

    Heterozygous superiority.

  • 15

    Malaria Before Columbus

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    Senegal

    Benin

    CAR

    IndiaItaly

    Greece

    Albania

    Turkey

    Arabian PeninsulaArabian Peninsula

    Origins of the Sickle Cell Gene

    Egypt

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    1/ td

    = kct

    cs

    !

    " #

    $

    % & n

    Kinetics of aggregation


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Regulatory Strategies: ATCase & Haemoglobinwebspace.qmul.ac.uk/rwjanes/basic_13_16_web.pdf · Myoglobin •Myoglobin is a single polypeptide, hemoglobin has four polypeptide chains

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uh.eduuh.edu/sibs/faculty/cstath/Chapter10_1.pdf · hemoglobin Y = 0.5 Pso myoglobin = 1 Torr hemoglobin = 26 Torr the oxygen dissociation curve of myoglobin is hyperbolic, whereas

biochemistry of MYOGLOBIN & HEMOGLOBIN

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Hemoglobin and Myoglobin”ΟΜΗ... · Myoglobin Hemoglobin Role of 2,3-BPG The Hemoglobin Genes Hemoglobinopathies Search Web themedicalbiochemistrypage.org Return to The Medical

Ch. 7 Protein Function and Evolution. Myoglobin and Hemoglobin Both are essential for oxygen need Myoglobin stores O 2 in the muscle Hemoglobin transports

HEMOGLOBIN. Structure of Heme Heme is the prosthetic group of hemoglobin, myoglobin, & cytochromes MVMVMPPM

Chem 452 - Lecture 3 Hemoglobin & Myoglobin 111003 · Chem 452 - Lecture 3 Hemoglobin & Myoglobin 111003 Hemoglobin (Hb) and Myoglobin (Mb) function as oxygen transport and storage

Myoglobin & Hemoglobin Structure, Function & malfunction of Biomolecules

Myoglobin and Hemoglobin

Myoglobin vs Hemoglobin Module 5 Lecture 14 Slide 15

Hemoglobin Dan Myoglobin

Hemoglobin and Myoglobin 2010

Globular Proteins Hemoglobin & Myoglobin Myoglobin - monomer. Single peptide chain and one heme unit –The heme unit contains an Fe atom (prosthetic group)