huigens lab university of florida department of...
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A “Chemistry-First” Drug Discovery Cycle
Small Molecule
Design
Organic Synthesis of
Small Molecules
Biological Evaluation
of Small Molecules
Huigens Lab
- Organic synthesis of novel compounds
- Natural product synthesis
- Focused library synthesis
- Combinatorial library synthesis
- Lead compounds from biologically active
natural products, high-throughput screens
and virtual screens
- Evaluate small molecules against
pathogenic bacteria and cancer cells
- Therapeutic areas: antibacterial agents,
personalized anticancer agents
Our lab identifies novel
biologically active small
molecules of medicinal
importance using this
drug discovery cycle.
Dr. Nicholas Borrero
Postdoctoral Fellow
Ph.D. in Chemistry
University of Florida
(joined 4/2013)
Nicholas Paciaroni
Graduate Student
B.S. in Chemistry
Clemson University
(joined 7/2013)
Aaron Garrison
College of Pharmacy Graduate School Fellow
Graduate Student
B.S. in Biochemistry
University of South Florida
(joined 8/2013)
Cristian Perez
Undergraduate Student
(joined 6/2013)
The Wrecking Crew
Our goals are to wreck
various functions of bacterial
and cancer cells alike through
the use of novel small
molecules designed and
synthesized in our labs.
Former Wrecking Crew Members
Benjamin Duong
PharmD Student
University of Florida
College of Pharmacy
Summer Research
(5/2013 – 8/2013)
Getting the Lab Started
Dr. Nick unpacking our first large order!
Empty labs in April 2013.
Ready to get to work!
Organic Synthesis in the Huigens Lab
Chemical synthesis of antibiofilm agents, antibacterial
agents and personalized cancer therapeutics.
Dr. Borrero running an NMR of a new compound.The beginning of the Huigens Lab small molecule
library for drug discovery.
Generating Novel Small Molecules for Drug Discovery
“I own this compound.”
Aaron discusses a reaction with Cristian. Nick and Cristian working hard.
Training Tomorrow’s Leaders in Science and Medicine
Dr. Huigens has been seen in the NMR lab on multiple occasions
“The art of making a new organic compound is only exceeded
by the skill required to purify that compound.”
“Publish that
NMR!!!”
“Compound purity is
absolutely critical in
this business.”
NMR spectra of biologically
active natural products and
synthetic compounds