ian seppelt: icu in review

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Seppelt ranges over a year of fraudulent behaviour, reviews, and news in intensive care.

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  • 1.Less is More Advances in Intensive Care in 2012 Dr Ian Seppelt Dept of Intensive Care Medicine, Nepean Hospital, and George Institute for Global Health,

2. A personal view of 2012 1. New intensive care literature and publications 2. New approaches to research methodology 3. New advances in (lack of) research ethics 3. A personal view of 2012 1. New intensive care literature and publications 2. New approaches to research methodology 3. New advances in (lack of) research ethics Less is more Dont just do something, stand there! 4. A personal view of 2012 1. New intensive care literature and publications 2. New approaches to research methodology 3. New advances in (lack of) research ethics Less is more Dont just do something, stand there! Law 13: The delivery of good medical care is to do as much Nothing as possible The Fat Man 5. Perner: New Engl J Med 2012 6. Perner: New Engl J Med 2012 7. Perner: New Engl J Med 2012 8. Perner: New Engl J Med 2012 9. Updated systematic review: mortality Gattas: Under review 10. Updated systematic review: RRT Gattas: Under review 11. ` 12. ` 13. Research Fraud - Joachim Boldt German Medical Board Issues Sweeping Findings in Boldt Case Ninety studies implicated in probe, might require retraction by Adam Marcus Unglaublich is the German word for unbelievable, and it's an apt description for the latest development in the case of Joachim Boldt, MD, PhD. Dr. Boldt, a prominent German anesthesiologist, has been at the center of a research and publishing scandal since last October, when the journal Anesthesia & Analgesia retracted a 2009 article of his over concerns of data manipulation. 14. 2012 A new record 15. 2012 A new record 16. 2012 A new record 17. 2012 A new record The top 4 clinical research frauds are all anaesthetists, intensivists or perioperative physicians 18. 2012 A new record The top 4 clinical research frauds are all anaesthetists, intensivists or perioperative physicians 19. 2012 A new record The top 4 clinical research frauds are all anaesthetists, intensivists or perioperative physicians 1. YoshitakaFuji 20. Research Integrity 21. Research Integrity 22. Research Integrity 1. CHEST Prespecied and published protocol and statistical analysis plan Should now be standard 23. Research Integrity 1. CHEST Prespecied and published protocol and statistical analysis plan Should now be standard 2. 6S Writing committee blinded until after results section and 24. Research Integrity 1. CHEST Prespecied and published protocol and statistical analysis plan Should now be standard 2. 6S Writing committee blinded until after results section and 25. Research Integrity 1. CHEST Prespecied and published protocol and statistical analysis plan Should now be standard 2. 6S Writing committee blinded until after results section and 26. Where next? Choice of uid? 27. Where next? Choice of uid? 28. NHMRC funding announced Oct 18th, 2012 $2,384,173.35 Where next? Fluid restriction? 29. ARDS 30. ARDS 31. Results 32. Results 33. Nutrition in ICU 34. Nutrition in ICU 1.Core business of critical medicine 35. Nutrition in ICU 1.Core business of critical medicine 2.We consistently deliver 2/3 of (prescribed) target nutrition in rst few days, up to 80-90% by a week Are we just no good at it? Or does it matter? 36. Nutrition in ICU 1.Core business of critical medicine 2.We consistently deliver 2/3 of (prescribed) target nutrition in rst few days, up to 80-90% by a week Are we just no good at it? Or does it matter? 3.Targets of nutrition have never been validated in the critically ill Anorexia and catabolism is a normal adaptive stress response Schoeld and Harris-Benedict purely empirical guesswork Even calorimetry gives an energy consumption 37. Nutrition in ICU 38. Nutrition in ICU 39. Nutrition in ICU 40. Nutrition in ICU 41. Nutrition are the endpoints all wrong? 42. Nutrition are the endpoints all wrong? 43. Nutrition are the endpoints all wrong? 44. Nutrition are the endpoints all wrong? 45. Traumatic Brain Injury 46. Imaging and clinical examination 47. Emerging infectious diseases 48. Emerging infectious diseases 49. Emerging infectious diseases 50. Novel research responses 51. Novel research responses 52. Novel research responses 53. [email protected] Questions ?