Improving Prophylactic Treatment of GBS Positive Patients

Improving Prophylactic Treatment of GBS Positive PatientsMichelle BlythersLiterature Review PresentationSenior ProjectOctober 22, 2014

Introduction

A high priority should be placed on identifying Group B Streptococcus (GBS) positive mothers and the appropriate administration (>4 hours prior to delivery) of prophylactic antibiotics.

Importance of Change:

GBS is the leading cause of sepsis, pneumonia and meningitis in the early newborn period, which is defined a the first week of life.

Identifying/screening and adequately treating GBS positive mothers, increases positive patient outcomes.

Article #1 Berardi, A.,Rossi,C.,Biasini, A. Minnitti, S., Venturelli, C., Ferrari, Faccinetti, F. (2011) Efficacy of intrapartum chemoprophylaxis less than 4 hours duration. The Journal of Maternal-Fetal and neonatal medicine 21(4): 619-625The data in this article were collected over 12 months, in 2 different hospitals.This was a quantitative study to compare rate of vertical transmission of GBS in women with no other risk factors.The findings were valid.

Article #2 Turrentine, M. Greisinger, A., Brown, K., Wehmanen, O., Mouzoon, M. (2013). Duration of intrapartum antibiotics for group b streptococcus on the diagnosis of clinical neonatal sepsis. Infectious Disease in obstretrics and Gynocology, 1-6.doi:10.1155/2013/525878This particular study was done in a large facility which delivers over 8,000 infants a year.It was retrospective cohort study of.The results were that infants whose mothers received