1145

INDEX

Volume 238, July-September, 1986

A23187, endothelium-dependent relaxation,pulmonary vessels, 1055

Abel, P. W., see Moore, D. H., 76Abernathy, D. R., see Todd, E. L., 642Acara, M. A., see Ferniola, P. C., 912Acetaminophen

conjugation, reduced hepatic energy stateeffects (rats), 463

hepatotoxicity, glutathione role in pre-vention, N-acetyl-L-cysteine (mice),54

pharmacokinetic studies, disposition, ma-ternal-placental-fetal unit (sheep),

198

Acetazolamide

bone resorption and (mice), 778renal sodium/potassium-ATPase trans-

port rate, transcellular NaC1 reab-sorption (dogs), 327

Acetazolamine, prostatic secretion, drug-modified ion transport (dogs), 26

Acetylcholinedopamine interactions, release modula-

tory receptors (rabbits), 437

endothelium-dependent relaxation, pad-monary vessels, 1055

muscarinic receptors, brain, N-methyl-scopolamine binding to (rats), 554

release, presynaptic a�pha-1 receptormodulation of, atria (rats), 612

N-Acetyl-L-cysteine, acetaminophen-in-duced hepatotoxicity, glutathionerole in prevention (mice), 54

Adenosine analogs, vasodilator effects,spontaneous hypertension (rats), 954

Adenosine 3’-phosphate 5’phosphoaulfate,hepatic energy state, conjugation and

(rats), 457

Adenosine tniphosphatase, renal sodium

and potassium transport rate, trans-cellular sodium chloride reabsorption(dogs), 327

Adenylate cyclaseadrenergic receptors to, atria (dogs), 886forskolin-stimulated, serotonin inhibi-

tion, hippocampal membranes(guinea pigs, rats), 248

Adkinson, N. F., Jr., see Peters, S. P, 8

Adler, M. W., see Klemfuss, H., 788

Adrenergic nerves, cardiac acceleration,pharmacological analysis (rats,

guinea pigs), 713Adrenoceptors

a�phaCH-38083 effects (guinea pigs, rats,

mice), 701maintenance of neurogenic tone and,

hindlimb vasculature (dogs), 599mechanical responses, airway smooth

muscle (dogs), 679

modulation of nociceptive jaw-opening

reflex (rats, rabbits), 576vascular smooth muscle, Schild plot

limitations, 237

�1

agonists, calcium utilization in aorta(rats), 224

effect of cooling, saphenous and femo-ral veins (dogs), 139

pressor responses and receptor reserve,calcium antagonists (rats), 89

response coupling, saphenous and fern-oral veins (dogs), 131

vasoconstriction, pulmonary circula-tion (dogs), 217

a�pha-2effect of cooling, saphenous and femo-

ral veins (dogs), 139

response coupling, saphenous and fern-oral veins (dogs), 131

studies that question the existence of,tail arteries (rats), 267

vasoconstriction, pulmonary circula-tion (dogs), 217

alpha agonistsantagonists, antihypertensive effects

(rats), 372control of microvascular reserve, myo-

cardiurn (rabbits), 868mechanical rsponses, airway smooth

muscle (dogs), 679radioligand selectivity, quantitative

analysis, 46

sympathetic transmission, heart (dogs),

334thrombin-stirnulated contraction and,

arteries (rabbits), 954alpha-i and a�pha-2, differential inhibi-

tion by nitroglycerin, saphenous vein(dogs), 515

beta-2, cardiovascular responsiveness,sympathetic activation after api-nephnine (rats), 148

Adrenocorticotropin, desensitization, stirn-ulatory effects of nicotine (rats), 486

Aging, coronary arteries, transrnural electri-cal stimulation, catecholarnines(dogs), 319

Ahrned, B., see Allen, D. 0., 659

Airway

smooth musclephosphatidylinositol response, cholin-

ergic agonists (cattle), 273relaxation, verapamil, isoproterenol

and prostaglandin E, (dogs), 76Akera, T., see Berlin, J. R., 632Albers, L. J., see Hess, E. J., 846Alcohol, central nervous system depressant,

long- and short-sleep (mice), 1028Aleen, A., see Cicero, T. J., 1063

A!kadhi, K. A., Sabouni, M. H., Ansari, A.F. and Lokhandwala, M. F.: Activa-

tion of DA1 receptors by dopamine orfenoldopam increases cyclic AMP

levels in the renal artery but not inthe superior cervical ganglion of therat, 547

Allan, A. M. and Harris R. A.: Anestheticand convulsant barbiturates alter ‘y-

aminobutynic acid-stimulated chlo-

ride flux across brain membranes,763

Allen, D. 0., Ahmed, B. and Naseer, K.:

Relationships between cyclic AMPlevels and lipolysis in fat cells afterisoproterenol and forskolin stirnula-tion, 659

Ally! alcohol, hepatotoxicity due to, liverlobule (rats), 1132, 1138

Ambrose,. F., see Rinehart, R. K., 178Amiloride, prostatic secretion, drug-modi-

fled ion transport (dogs), 26Amino acids

enzyme inactivation, retina vs. brain(rats), 508

excitatory, striatum, phencyclidine effects

(rats), 938-y-Aminobutynic acid

chloride flux, barbiturate alteration of,brain membrane (mice), 763

enzyme inactivation, retina vs. brain(rats), 508

Aminoglycoside, nephrotoxicity, gentamicintransport, 1071

Aminopyrine N-demethylase, hepatic mon-

ooxygenase system, persistent de-fects, phenytoin (rats), 68

Aniiodarone, induced biotransformation,ventricular refractory periods (rats),307

Amphetamine, mydniasis, mechanism

(rats), 788

Arnygdala, antidepressant drugs injectedinto, behavioral responses and (rats),758

Analgesia, dynorphin A, administered in-trathecally, spinal cord (rats), 833

Anestheticsantihistamines and, excess tachycardia

(dogs), 367nitrous oxide, effect on embryos (rats),

985

Angiotensin, enzyme conversion inhibitor,

lungs (rabbits), 14Angiotension antagonist, sympathetic vaso-

constriction and renin secretion,presser responses, thyrotropin-re-

leasing hormone (rats), 232Aniline, metabolism and toxicity, hemolytic

anemia (rats), 1045Anions, exchange, bumetanide inhibition of,

renal thick limbs (mice), 407Ansari, A. F., see A!kadhi, K. A., 547Antagonists, see specific type

Antiarrhythmic agentsamiodarone, induced transformation,

ventricular refractory period (rats),307

dantrolene sodium, isolated sinoatrial andatrioventricular nodes, ischemiamodel (rabbits, dogs), 206

Anticonvulsantsaction, repetitive firing in central neurons

(rats), 727

behavioral toxicity, chronic ethosuximide

1146 Index Vol. 238

and sodium valproate, epilepsy (ba-

boons), 32

modulation of behavioral effects, external

discriminative stimulus (pigeons),

529

phenytoin, hepatic monooxygenase sys-tern, persistent defects (rats), 68

Antidepressant drugs, injected into amyg-

dala, behavioral responses and (rats),

758

Antidiuretic hormoneinhibition of transepithelial water flux,

urinary bladder (toad), 401prostaglandins and, water handling,

renal, 653Antiepileptic agents, behavioral toxicity,

chronic ethosuximide and sodium

valproate (baboons), 32

Antihistamines, local anesthetics and, ex-cess tachycardia (dogs), 367

Antihypertensive agents, profile and phar-macology (rats), 473

Anti-inflammatory drugs

2-arylpropionic acid, enantioselective dis-

position (rabbits), 280, 288tenoxicam, acceleration of elimination,

cholestyramine (dogs), 295Antipsychotic drugs, depolarization block

induction, midbrain dopamine neu-rons (rats), 1092

Antonaccio, M. J., High, J., DeForrest, J.

M. and Sybertz, E.: Antihypertensiveeffects of 12 beta adrenoceptor antag-onists in conscious spontaneously hy-pertensive rats: Relationship to

changes in plasma renin activity,heart rate and sympathetic nerve

function, 378Anxiolytic drugs, behavioral studies (pi-

geons), 1009Aorta

calcium utilization, full and partial a’pha-

1 adrenoceptor agonists (rats), 224contraction, dihydropynidines and (rab-

bits), 670

endothe!ium-derived relaxing factor, ac-tivated production, acyl-coenzymeA:lysolecithin acyltransferase inhib-

itors (rabbits), 352

thoracic, threshold synergism and poten-tiation (rabbits), 802

Apical membrane, sodium permeability, de-tangent effects (toads), 415

Apomorphine

drug interactions, autoreceptors (rabbits),

437

supersensitivity, rotational behavior(mice), 242

Aprotinin, segmental nephron function(rats), 155

AQ-A39, beneficial effects of, reversiblemyocardial reperfusion damage,

anesthesia and (dogs), 422AQ-AH 208, beneficial effects, reversible

myocardial reperfusion damage,anesthesia and (dogs), 422

Arachidonic acidesterification and release, p-hydroxymer-

curibenzoic acid effects, islets (rats),

809lung mediator release, reduced oxygen

tension, 8stimulus-secretion coupling and, insulin

release (rats), 819Anisteromycin, hypotension and renal vaso-

dilator effects, spontaneous hyper-tension (rats), 954

Artaud, F., see Bourgoin, S., 360Artery

coronary, age-dependent changes, cats-cholamines (dogs), 319

smooth muscle and endothelium, musca-rinic receptors, characterization (rab-bits), 100

tail, a�pha-2 adrenoceptors, question of

existence (rats), 267

2-Arylpropionic acid, enantioselective dis-position, nonsteroidal anti-inflam-

matory drugs (rabbits), 280, 288Atchison, W. D., Joshi, U. and Thornburg,

J. E.: Irreversible suppression of cal-cium entry into nerve terminals bymethylmercury, 618

Atkinson, T., see Electnicwala, A., 254

Atniaacety!choline release, presynaptic alpha-i

receptor modulation of (rats), 612beta adrenergic subtypes in (dogs), 886

quinidine and digoxin, pharmacodynamicinteractions between (guinea pigs),632

right, transmural nerve stimulation(guinea pigs, rats), 713

Atnial natriuretic peptide, tubular site ofaction, anesthesia and (dogs), 707

Atropine

antihistamines and local anesthetics, ax-cess tachycardia (dogs), 367

gastrointestinal effects of hyperserotoni-nemia and (dogs), 536

Autoradiography

benzodiazepine receptors, regulation, im-

aging (rats), 739localization of delta opioid receptors,

brain (rats), 720

Badr, M. Z., Belinsky, S. A., Kauffman, F.C. and Thurman, R. G.: Mechanismof hepatotoxicity to periportal re-

gions of the liver lobule due to a!lylalcohol: Role ofoxygen and lipid per-oxidation, 1138

Bath, M. Z., see Be!insky, S. A., 1132Banner, W., Jr., see Hynes, M. R., 100Barbaz, B., see Rinehart, R. K., 178Barbital, central nervous system depres-

sant, long- and short-sleep (mice),1028

Barbiturates

anesthetic and convulsant, y-aminobu-tyric acid-stimulated chloride flux

and, brain membranes (mice), 763related depressant drugs and, recurrent

inhibition of hippocampus (rats), 564Bardales, R. M., see Shapiro, B. H., 68Barium chloride, jejunal contractility, after

chronic ablation, myenteric plexus(rats), 372

Barnes, J. G., see Schwertsch!ag, U., 653Barnes, P. J., see Grandordy, B. M., 273

Barrett, J. E., Witkin, J. M., Mansbach, R.S., Skolnick, P. and Weissman, B. A.:Behavioral studies with anxio!yticdrugs. III. Antipunishment actions of

buspirone in the pigeon do not in-volve benzodiazepine receptor mech-anisms, 1009

Basilar artery, vasoconstnictor neurotrans-mitter in, serotonin as (rabbits), 880

Bass, P., see Fox, D. A., 372

Bay K 8644, dihydropyridine derivativesand, vascular and cardiac effects(rabbits, guinea pigs), 670

Begaud, B., see Chel!y, J. E., 665Behavior

anticonvulsant drug effects, modulationby external discriminative stimulus

(pigeons), 529rotational, supersensitivity, apomorphine

(mice), 242

schedule-controlled, benzodiazepine-like

drugs (monkeys), 522toxicity, chronic ethosuximide and so-

chum valproate, epilepsy (baboons),32

Belinsky, S. A., Badr, M. Z., Kauffman, F.C. and Thurman, R. G.: Mechanism

of hepatotoxicity in peniportal re-gions of the liver lobule due to allyl

alcohol: Studies on thio!s and energystatus, 1132

Belinsky, S. A., see Bath, M. Z., 1138Belis, J. A., see Longhurst, P. A., 773

Benet, L. Z., see Wang, L. H., 198

Benza!konium chloride, jejunal contractil-ity, after chronic ablation, myentenicplexus (rats), 372

Benzodiazepinesbehavioral effects (monkeys), 522

interactions, central thyroid-releasinghormone binding sites (rats), 178

peripheral-type, downregulation of [3HJR05-4864 binding sites, 855

receptors, see ReceptorsBenzoflavones, activity, placental tissues

(rats), 1108Bepridil, stimulation, cardiac myofilaments

(pigs), 502Bergen, J. and Kroeger, E. A.: Adreno-

ceptor-mediated mechanical re-sponses of canine tracheal smooth

muscle, 679Berlin, J. R., Akera, T. and Brody, T. M.:

Lack of pharmacodynamic interac-tions between quinidine and digoxinin isolated atrial muscle of guinea pigheart, 632

Bernath, S., see Vizi, E. S., 701Bestatin, kelatorphan, Met-enkephalin-like

release, spinal cord (rats), 360Bevan, J. A., see Garland, C. J., 947Beyer, H. S., see Sharp, B. M., 486

BHT-920, alpha-2 adrenoceptors, questionof existence, tail arteries (rats), 267

Bicarbonate, bumetanide action, renal thicklimbs (mice), 407

Biiary excretion, acetaminophen conjuga-tion, hepatic energy state and (rats),457

Billings, R. E., see Hansen, D. K., 985Binding assay, cyclosponine (mice), 39Bis-penicillamine cyclic enkephalin, locali-

zation ofdetta opioid receptors, brain(rats), 720

Bittiger, H., see Rinehart, R. K., 178

Bjork, F. A., see Ryan, M. J., 473Bjornsson, T., see Moorman, J. R., 159

Blanchard, J. S., see Cubells, J. F., 508Blood flow

myocardial ischemia, novel calcium an-

tagonist (dogs), 113regional, hydralazine effects, conscious

state (dogs), 665renal, a-hANP and (dogs), 707

Blood pressure

1986 Index 1147

beta adrenoceptor antagonists, antihyper-tensive effects (rats), 372

experimental diabetes, insulin effects on

urinary eicosanoid excretion (rats),606

sympathectomy and (rats), 1014

sympathetic vasoconstriction and renin

secretion, thyrotropin-releasing hor-mone (rats), 232

Bocchetta, A., see Corsini, G. U., 648Bombesin, gastrointestinal transit, colonic

bead expulsion, supraspinal mecha-nisms (mice), 62

Bouboutou, R., see Bourgoin, S., 360Bourgoin, S., Le Bars, D., Artaud, F., Clot,

A.-M., Bouboutou, R., Fournie-Zalu-ski, M.-C., Roques, B. P., Hamon, M.

and Cesselin, F.: Effects of kelator-phan and other peptidase inhibitorson the in vitro and in vivo release ofmethionine-enkephalin-like materialfrom the rat spinal cord, 360

Bousquet, P., see Solaro, R. J., 502Brady, J. V., see Lukas, S. E., 924

Bradycardic agents, beneficial effects, re-versible myocardial reperfusion dam-age, anesthesia and (dogs), 422

Bradykinin, eicosanoid synthesis, hydrone-phrotic cortical interstitial cells (rab-bits), 95

Brain

7-aminobutynic acid enzyme inactivation(rats), 508

bombesin, gastrointestinal transit and co-lonic bead expulsion, supraspinal

mechanisms (mice), 62chloride channels, barbiturate effects

(mice), 763

formation of 1-methyl-4-phenyl-1,2,3,6-

tetrahydropynidine, monoamine oxi-dase and (rats), 648

localization of delta opioid receptors, au-toradiography (rats), 720

muscaninic acetylcholine receptors, N-methylscopolamine binding to (rats),

554sigma and phencyclidine receptor binding

sites, autoradiography (rats), 739

Breaux, S. P., see Maderazo, E. G., 453Breeding, genetically prone or resistant to

seizures, ethanol withdrawal (mice),170

Breese, G. R., see Duncan, G. E., 758Brenner, D., see Nielson, C. P., 19Brody, T. M., see Berlin, J. R., 632Brown, J. H. and Goldstein, D.: Analysis of

cardiac muscarinic receptors selec-tively recognized by nonquaternarybut not by quaternary ligands, 580

Brown, J. H., see McDonough, P. M., 612Bruckert, J. W., see Mills, E., 1014Buchan, P., see Wei, E. T., 783

Bumetanide, inhibition of electrical flux,renal thick limbs (mice), 407

Bu#{241}ag, R. D., see Mattila, J., 232Bunney, B. S., see Grace, A. A., 1092Burks, T. F., see Galligan, J. J., 594Burks, T. F., see Koslo, R. J., 62Buspirone

antipunishment actions (pigeons), 1009serotonin inhibition, forskolin-stimulated

adenylate cyclase, hippocampalmembranes (guinea pigs, rats), 248

Busse, R., see F#{246}rstermann, U., 352

Caffeine, chronic administration, locomotoractivity and (rats), 542

Calcium

A23187, eicosanoid synthesis, hydrone-phrotic cortical interstitial cells (rab-bits), 95

antagonistscahnodu!in binding drugs, renal cell an-

oxia (rabbits), 119KB-944, myocardial ischemia (dogs),

113receptor reserve, alpha-i adrenoceptor-

mediated presser responses (rats), 89

verapamil and morphine interactions,

physiological parameters (rats), 192

cytoplasmic free concentration, maito-toxin effects, heart muscle (guineapigs, rats), 1077

cytosolic, hepatocytes exposed to carbontetrachloride (rats), 186

entry, synaptosomes, suppression bymethylmercury (rats), 618

stimulation, bepridil, heart (pig), 502ultilization, aorta, full and partial alpha-

1 adrenoceptor agonists (rats), 224Calcium channel

antagonistdepolarization-dependent binding,

PC12 cells, 1021serotonin receptor activation and,

uterus and jugular vein (rats), 860blockers and calmodulin binding drugs, in

vitro renal cell anoxia (rabbits), 119

dantrolene sodium, isolated sinoatrial and

atrioventricular nodes, ischemiamodel (rabbits, dogs), 206

heavy metal inhibition, nerve terminals(rats), 618

inhibition, oNCS-DHP (guinea pig), 1084prostaglandin E, synthesis, verapamil ef-

fact, hydronephrotic cortical intersti-

tial cells (rabbits), 125Calmodulin, binding drugs and calcium

channel blockers, in vitro renal cellanoxia (rabbits), 119

Captoprilangiotensin-converting enzyme inhibitor,

uptake of N-[1(S)-carboxy-(4-OH-3-‘�I-phenyl)ethylJ-L-ala-L-pro, lungs(rabbits), 14

sympathetic vasoconstriction and reninsecretion, pressor responses, thyro-tropin-releasing hormone (rats), 232

Carbachol, forskolin interaction, cyclicGMP lowering agent LY83583, car-diac preparations (rabbits), 313

Carbamazepine, repetitive firing and, cen-tral neurons (mice), 727

Carbocyclic adenosine, hypotensive and

renal vasodi!ator effects, sponta-neous hypertension (rats), 954

Carbonic anhydrase, bone resorption and(mice), 778

Carbon tetrachloride, exposed hepatocytes,cytosolic calcium (rats), 186

�yl-L-ala-L-pro, uptake, angiotensin-converting enzyme inhibitor, lungs(rabbits), 14

Carcinogenesis, chemical, nitrofurothiazole,bladder (rats), 457

Cardiac myocytes, maitotoxin effects(guinea pigs, rats), 1077

Cardinal, R., see Lambert, C., 307Cardiovascular system

interactions between verapamil and mor-phine, physiological parameters(rats), 192

responsiveness, beta adrenoceptors, epi-

nephrine (rats), 148sympathetic vasoconstriction and renin

secretion, pressor responses, thyro-tropin-releasing hormone (rats), 232

Carpenter, C. L., see Greenberg, D. A., 1021Carpenter, R., see Cohen, M. L., 860Carroll, M. E., Lac, S. T., Walker, M. J.,

Kragh, R and Newman, T.: Effects

of naltrexone on intravenous cocaineself-administration in rats during

food satiation and deprivation, 1Catecholamines, isolated coronary arteries,

age-dependent changes (dogs), 319

Central nervous system depressants, long-and short-sleep with (mice), 1028

Cesselin, F., see Bourgoin, S., 360CGS 13080, thrombosis and, coronary ar-

tery (dogs), 497CGS 8216, antagonism, benzodiazepine-like

drugs (monkeys), 522Chapman, K. L., see Marwood, J. F., 267Chelly, J. E., Doursout, M.-F., Begaud, B.,

Tsao, C. C. and Hartley, C. J.: Effectsof hydralazine on regional blood flowin conscious dogs, 665

Chiu, A. T., McCall, D. E., Thoolen, M. J.M. C. and Timmermans, P. B. M.M.: Ca4� utilization in the constric-tion of rat aorta to full and partialalpha-i adrenoceptor agonists, 224

Chloral hydrate, central nervous system de-pressant, long- and short-sleep(mice), 1028

Chloride, absorption, thiazide diuretic ef-fects, distal colon (rabbits), 912

Chloride-bicarbonate exchange, thiazide di-uretic effects, distal colon (rabbits),912

Chioroquine, leukocytes, mechanisms of cellassociation, 302

Cholesterol, synthesis, ketoconazole effects,905

Cholestyramine, tenoxicain, acceleration ofelimination (dogs), 295

Cholinergic agonists, phosphatidylinositol

response, airway smooth muscle (cat-tle), 273

Cholinergic nerves

cardiac acceleration, pharmacologicalanalysis (rats, guinea pigs), 713

peripheral, intestinal motility and (rats),

594Chuang, D.-M., see Roth, B. L., 480Chung, A. Y. K., see Turrin, M., 14Cicero, T. J., Aleem, A., Meyer, E. R.,

Schmoeker, P.F. and Miller, B. T.:Opiate withdrawal-induced hyposen-sitivity to naloxone’s effects on

serum luteinizing hormone in themale rat, 1063

Ciliax, B. J., Penney, J. B., Jr. and Young,A. B.: In vivo [3H]flunitrazepambinding-. Imaging of receptor regula-tion, 749

Cimetidine, pharmacological comparison,

H2 blockers (dogs), 587

Cioffi, C. L. and El-Fakahany, E. E.: Short-term desensitization of muscariniccholinergic receptors in mouse neu-

roblastoma cells: Selective loss of ag-

1148 Index Vol. 238

onist low-affinity and pirenzepinehigh-affinity binding sites, 916

Cirazoline, alpha-i and a�pha-2 adrenocep-tors, response coupling, saphenousand femoral veins (dogs), 131

Cl-926, antihypertensive activity (rats), 473CL 218,872, behavioral effects (monkeys),

522Clark, M. B., see Turnin, M., 14Claustre, Y., Rivy, J. P., Dennis, T. and

Scatton, B.: Pharmacological studies

on stress-induced increase in frontalcortical dopamine metabolism in the

rat, 693Clonidine

a�pha-2 adrenoceptors, question of exist-ence, tail arteries (rats), 267

jaw-opening reflex and, nociceptive (rats,

rabbits), 576Clot, A.-M., see Bourgoin, S., 360

Cocainedrug interactions, autoreceptors (rabbits),

437

self-administration, naltrexone effects

(rats), 1Cohen, D. M., see Ryan, M. J., 473

Cohen, M. L., Carpenter, R., Schenck, K.,Wittenauer, L. and Mason, N.: Effectof nitrendipine, diltiazem, trifluoper-azine and pimozide on serotonin2 (5-HT2) receptor activation in the ratuterus and jugular vein, 860

Cohen, M. L., Shuman, R T., Osborne, J.J. and Gesellchen, P. D.: Opioid ag-onist activity of IC! 174864 and itscarboxypeptidase degradation prod-uct, LY281217, 769

Collins, A. C., see Manley, R. J., 1028

Colon, distal, chloride absorption, thiazidediuretic effects (rabbits), 912

Conjugation, pharmacokinetic studies, ac-etaminophen disposition, maternal-placental-fetal unit (sheep), 198

Contreras, P. C., Johnson, S., Freedman, R.,Hoffer, B., Olsen, K., Rafferty, M. F.,Lessor, R. A., Rice, K. C., Jacobson,A. E. and O’Donohue, T. L.: Mets-phit, an acylating ligand for phency-clidine receptors: Characterization ofin vivo actions in the rat, 1101

Corcoran, G. B. and Wong, B. K.: Role ofglutathione in prevention of acetami-nophen-induced hepatotoxicity by N-

acetyl-L-cysteine in vivo: Studieswith N-acetyl-D-cysteine in mice, 54

Corsini, G. U., Pintus, S., Bocchetta, A.,Piccardi, M. P. and Del Zompo, M.:A reactive metabolite of 1-methyl-4-

phenyl-1,2,3,6-tetrahydropyridine is

formed in rat brain in vitro by type

B monoamine oxidase, 648Corticosterone, kappa opioid receptor ef-

fects, hypothalamic-pituitary-adren-

ocortical axis (rats), 429Corticotropin-releasing factor, neurogenic

plasma extravasation and, paw (rats),783

Costa, E., see Roth, B. L., 480

Costa,M.,seeGalligan,J.J., 1114Coughenour, L. L., see Ryan, M. J., 473Covey, J. B., see Duncan, G. E., 758

Crabbe, J. C., see Kosobud, A., 170Creese, I., see Hess, E. J., 846Cniswell, H., see Duncan, G. E., 758

Cubeddu, L. X, see Hoffmann, I. S., 437

Cubells, J. F., Blanchard, J. S., Smith, D.M. and Makman, M. H.: In vivo ac-tion of enzyme-activated irreversibleinhibitors of glutamic acid decarbox-ylase and ‘y-aminobutynic acid trans-aminase in retina vs. brain, 508

Curtis, A. L. and Marwah, J.: Evidence foralpha adrenoceptor modulation of thenociceptive jaw-opening reflex in ratsand rabbits, 576

Cuss, F. M., see Grandordy, B. M., 273

Cyclazocine, psychopharmacology of keto-cyclazocine compared with, 960

Cyclic AMPactivation of DA1 receptors, dopamine or

fenoldopam (rats), 547carbachol and forskolin interaction, car-

diac preparations (rabbits), 313

dibutyryl, bone resorption induced by(mice), 778

lipolysis relations, fat cells, isoproterenoland forskolin effects (rats), 659

Cyclic GMP, carbachol and forskolin inter-actions, cardiac preparations (rab-bits), 313

Cyclohexyladenosine, vasodilator effects,

hypotensive and renal (rats), 954

Cyclosporine, novel binding assay (mice), 39Cystopathy, diabetic (rats), 773Cytochrome P-450, inactivation and induc-

tion, psoralen derivatives (rats), 685

Daemmgen, J. W., see Gross, G. J., 422Danon, A., Zenser, T. V., Thomasson, D. L.

and Davis, B. B.: Effect of verapamilon prostaglandin E� synthesis by by-dronephrotic rabbit cortical intersti-

tial cells in primary culture, 125Danon, A., Zenser, T. V., Thomasson, D. L.,

Palmier, M. 0. and Davis, B. B.: El-cosanoid synthesis by rabbit hydro-nephrotic cortical interstitial cells inculture, 95

Dantrolene sodium, electrophysiological ac-tions, isolated sinoatrial and atrio-ventricular nodes, ischemia model(rabbits, dogs), 206

Davidenko, J., Delmar, M., Oates, R. andJalife, J.: Electrophysiological ac-

tions ofdantrolene sodium in isOlated

sinoatrial and atrioventricular nodes

and in a model of ischemia, 206Davis, B. B., see Danon, A., 95, 125, 457Defoin, R., see Guentert, T. W., 295DeForrest, J. M., see Antonaccio, M. J., 378

Delmar, M., see Davidenko, J., 206

Del Zompo, M., see Corsini, G. U., 648Dennis, T., see Claustre, Y., 693Depolarization-dependent binding, calcium

channel antagonist, PC12 cells, 1021Depressantdrugs, nonbarbiturate, recurrent

inhibition of hippocampus (rats), 564Descatoire, V., see Letteron, P., 685Desensitization

aortic smooth muscle contraction, pheo-chromocytoma (rats), 396

nicotine stimulatory effects, plasma adre-nocorticotropin and prolactin (rats),486

Desethyl-N-acetylprocainamide, cardiovas-

cular actions of (dogs), 893Detergents, sodium transport and, urinary

bladder (toads), 415Development, adrenergic, sympathectomy

and (rats), 1014

Developmental pharmacology, phenytoin,Purkinje fibers (dogs), 794

De Vivo, M. and Maayani, S.: Characteri-zation of the 5-hydroxytryptamine1Areceptor-mediated inhibition of for-skolin-stimulated adenylate cyclaseactivity in guinea pig and rat hippo-campal membranes, 248

Diabetes mellitus

streptozotocin-induced, urinary bladderdysfunction (rats), 773

urinary eicosanoid excretion, insulin ef-fects (rats), 606

Diamond, J., see MacLeod, K. M., 313Diarrhea, hyperserotoninemia, ketansenin,

atropine, and methysergide in (dogs),

536Diazepam, behavioral effects (monkeys),

522Diazoxide, chloride absorption and, distal

colon (rabbits), 912Diflunisa!, pharmacokinetics of, rena! fail-

ure (rats), 978Digoxin, interactions with quinidine, heart

atrial muscle (guinea pigs), 632Dihydroalprenolol, beta adrenergic recep-

tore, radioligand selectivity, quanti-tative analysis, 46

Dihydropynidines, vascular and cardiac ef-fects, comparison with Bay K 8644(rabbits, guinea pigs), 670

1,25-Dihydroxyvitamin D3, bone resorptionand (mice), 778

Dulls, R. L. and Klaassen, C. D.: Effect ofreduced hepatic energy state on ac-etaminophen conjugation in rats, 463

Diltiazem, serotonin contraction and, uterusand jugular vein (rats), 860

Diphenyl-phenylenediamine, lipid peroxi-dation and toxicity, gentamicin-in-duced (rats), 83

Diuretics, inhibition of electrical flux, renalthick limbs (mice), 407

DNA, synthesis, nitrous oxide effects, em-bryos (rats), 985

Donlon, M. A., see Newball, H. H., 839Donovan, D. W., see Smith, E. R., 26Dopamine

activation of DA, receptors, cyclic AMPlevels and (rats), 547

interactions, release modulatory receptors(rabbits), 437

metabolism, stress effects, prefrontal cor-

tex (rats), 693midbrain neurons, depolarization block

in, haloperidol and (rats), i092

neuromedin N activity and, ventral teg-mental area, 1126

supersensitivity, rotational behavior, apo-morphine (mice), 242

Dosing frequency, dependence and toler-ance to pentobarbital and (cats), 1004

Doursout, M.-F., see Chelly, J. E., 665Downregu!ation, binding site, [3H]R05-

4864, benzodiazepines and, 855Doxorubicin, polymorphonuclear leuko-

cytes, alterations in oxygen metabo-lite generation, 19

Doxorubicinol, induced alterations, oxygenmetabolite generation, polymorpho-nuclear leukocytes, 19

Drazen, J. M., see Rossing, T. H., 874Drug pI(, pH potentiation, sodium channel

blockade, ventricular myocardium

(guinea pigs), 159

1986 Index 1149

Duckles, S. P., see Hynes, M. R., 100Duckles, S. P., see Levitt, B., 880Duffey, M. E., see Ferriola, P. C., 912Duffy, T., see Kalivas, P. W., 1126Duggan, D. E., see Lin, J. H., 978Duncan, G. E., Breese, G. R., Criswell, H.,

Stumpf, W. E., Mueller, R. A. andCovey, J. B.: Effects of antidepres-sent drugs injected into the amygdalaon behavioral responses of rats in theforced swim test, 758

Dunham, E. W. and Vince, R.: Hypotensiveand renal vasodilator effects of car-bocyclic adenosine (anisteromycin) inanesthetized spontaneously hyper-tensive rats, 954

Dunwiddie, T. V., Worth, T. S. and Olsen,R. W.: Facilitation of recurrent inhi-bition in rat hippocampus by barbi-

turate and related nonbarbiturate de-pressant drugs, 564

Duodenum, neurokinins, motor effect (rats),341

Dynorphin, plasma concentrations and, an-tenor pituitary hormones (primate),

974Dynorphin A, administered intrathecally

(rats), 8.33

Ehrhard, P., see Kozlowski, R., 1084

Eicosanoidssynthesis, hydronephrotic cortical inter-

stitial cells (rabbits), 95urinary excretion, insulin effects, experi-

mental diabetes mellitus and (rats),606

Eikenburg, D. C., see Schwartz, D. D., 148

Electricwala, A., Emeis, J. J. and Atkinson,T.: Evaluation of epithelial tissueplasminogen activator as a thrombo-lytic agent in a rabbit model of ye-nous thrombosis, 254

Electrolytes, plasma, sodium-dependent by-pertension and vasopressin (rats),492

Electrophysiology, bumetanide action, renal

thick limbs (mice), 407El-Fakahany, E. E., see Cioffi, C. L., 916El-Fakahany, E. E., Ramkumar, V. and Lai,

W. S.: Multiple binding affinities ofN-methylscopolamine to brain mus-

caninic acetyicholine receptors: Dif-ferentiation from M, and M2 receptorsubtypes, 554

Emeis, J. J., see Electricwala, A., 254Enantiomers, 2-arylpropionic acid, disposi-

tion, 2-phenylpropionic acid (rab-bits), 280, 288

Endoplasmic reticulum, cytosolic calcium,

hepatocytes exposed to carbon tetra-chloride (rats), 186

Endothelium, ear artery smooth muscle and,muscarinic receptors, characteriza-tion (rabbits), 100

Endothelium-derived relaxing factor, acti-vated production, acyl-coenzymeA:lysolecithin acyltransferase inbib-itors (rabbits), 352

Endaley, B., see Picker, M., 529Enkaphalin, opioid agonist activity of IC!

174864 (mice), 769Enteric nervous system, myoelectric activ-

ity, nervous control (guinea pigs),

1114

Enzymes, angiotensin-converting, uptake of

N-[i(S)-carboxy-(4-OH-3-’9-phen-yl)ethyl]-L-ala-L-pro, lungs (rabbits),14

Epilepsy, behavioral toxicity, chronic etho-suximide and sodium valproate (ba-boons), 32

Epinephrinecardiovascular responsiveness, syinpa-

thetic activation (rats), 148isoproterenol and IPS-339, sympathetic

transmission, heart (dogs), 334Epithelial cells, plasminogen activator,

thrombolytic agent, venous throm-bosis (rabbits), 254

Eskinder, H. and Gross, G. J.: Differentialinhibition of Alpha-i us. alpha-2 ad-renoceptor-mediated responses in ca-nine saphenous vein by nitroglycerin,515

Ethanolcentral nervous system depressant, long-

and short-sleep (mice), 1028withdrawal, selective breeding, geneti-

cally prone or resistant to seizures(mice), 170

Ethionine, hepatic energy state, conjugationand (rats), 457

Etbosuximide, sodium valproate and, be-

havioral toxicity, epilepsy (baboons),32

Ethoxynesorufin-O-deethylase, differentialinduction, placental tissues (rats),1108

Evans, D. B., see Ryan, M. J., 473

Fallon, M., see Weiss, J., 969Fang, F. G., Fields, H. L. and Lee, N. M.:

Action at the mu receptor is suffi-dent to explain the supraspinal an-algesic effect of opiates, 1039

Fat cells, cyclic AMP levels and lipolysis in,isoproterenol and forskolin stimula-tion (rats), 659

Fenoldopam, activation of DA, receptors,

cyclic AMP levels and (rats), 547Ferrara, A., see Jaffe, B. M., 536Fernio!a, P. C., Acara, M. A. and Duffey, M.

E.: Thiazide diuretics inhibit chlorideabsorption by rabbit distal colon, 912

Fibrinolysis, epithelial tissue plasminogenactivator, thrombolytic agent, venousthrombosis (rabbits), 254

Field, E. and Tyrey, L.: Tolerance to the

luteinizing hormone and prolactinsuppressive effects of 6-9-tetrahydro-cannabinol develops during chronicprepubertal treatment of female rats,1034

Fields, H. L., see Fang, F. G., 1039Finn, I. B. and Holtzman, S. G.: Tolerance

to caffeine-induced stimulation of lo-comotor activity in rats, 542

Fischli, W., see Kozlowski, R., 1084Flavahan, N. A. and Vanhoutte, P. M.: Al-

pha-1 and alpha-2 adrenoceptor Re-

sponse coupling in canine saphenous

and femoral veins, 131Flavahan, N. A. and Vanhoutte, P. M.: Ef-

fect of cooling on alpha-i and alpha-

2 adrenergic responses in canine sa-pbenous and femoral veins, 139

Flunitrazepam, binding, imaging of receptorregulation (rats), 749

Folic acid, nitrous oxide effects, embryos(rats), 985

Forced swim test, antidepressant drug injec-tion and, amygdala (rats), 758

Formyl-methionyl-leucyl-phenylalanine,hypoxia induced by, ibuprofen and

methylprednisolone effects on (rab-

bits), 453Forskolin

carbachol interaction, cyclic GMP lower-

ing agent LY83583, cardiac prepara-tions (rabbits), 313

stimulation of fat cells, cyclic AMP andlipolysis relations in (rats), 659

F#{246}rstermann, U., Goppelt-Strube, M., Fr#{246}l-ich, J. C. and Busse, R.: Inhibitors ofacyl-coenzyme A:!ysolecithin-acyl-transferase activate the production of

endothelium-derived vascular relax-ing factor, 352

Fournie-Zaluski, M.-C., see Bourgoin, S.,360

Fox, D. A. and Bass, P.: Pharmacological

characterization of rat jejunal con-tractility after chronic ablation of themyenteric plexus, 372

Franz, D. R., see Newball, H. H., 839Freedman, R., see Contreras, P. C., 1101Friedman, P. A.: Bumetanide inhibition of

[CO2 + HCO3]-dependent and -inde-pendent equivalent electrical flux in

renal cortical thick ascending limbs,407

Frolich, J. C., see F#{246}rstermann, U., 352Fructose, hepatic energy state, conjugation

and (rats), 457Fujita, T., see Shebuski, R. J., 217j9-Funaltrexamine

ileal preparation (guinea pigs), 625morphine antagonism, locomotor activity

and (rats), 997

Furness, J.B., see Galligan, J. J., 1114Furosemide, prostatic secretion, drug-mod-

ified ion transport (dogs), 26

Gaal, J., see Vizi, E. S., 701Galligan, J. J., Furness, J. B. and Costa, M.:

Effects of cholinergic blockade, ad-renergic blockade and sympatheticdenervation on gastrointestinal my-oelectric activity in guinea pig, 1114

Galligan, J. J. and Burks, T. F.: Cholinergicneurons mediate intestinal propul-sion in the rat, 594

Garland, C. J. and Bevan, J. A.: Alpha ad-renoceptor antagonists selectively re-

duce thrombin-stimulated contrac-tion in rabbit arteries, 947

Gastric antisecretory action, H2 blocker,pharmacological comparison (dogs),587

Gastrointestinal tract, colonic bead expul-sion and, bombesin, supraspinal

mechanisms (mice), 62

Gehlert, D. R., see Gu!ya, K., 720

Geneve, J., see Letteron, P., 685Gentamicin

lipid peroxidation and toxicity, diphenyl-phenylenediamine effects, renal cor-

tex (rats), 83

transport, renal epithelial cell line, 1071Gerber, J. G., see Schwertschlag, U., 653Gesellchen, P. D., see Cohen, M. L., 769

Gibb, J. W., see Sonsalla, P. K., 932Gilbeau, P. M., Hosobuchi, Y. and Lee, N.

M.: Dynorphin effects on plasmaconcentrations of anterior pituitary

1150 Index Vol. 238

hormones in the nonhuman primate,974

Gillis, C. N., see Turrin, M., 14Ginsburg, R., see Rosenbaum, J. S., 396Giuliani, S., see Maggi, C. A., 259, 341Glial cells, LRM55, substance P receptors

On, 389

Glomerular filtration rate, a-hANP, tubularsite of action (dogs), 707

Glucuronidation, pharmacokinetic studies,

acetaminophen disposition, mater-nal-placental-fetal unit (sheep), 198

Glutamic acid decarboxylase, enzyme mac-tivation, retina vs. brain (rats), 508

Glutathioneconjugation, reduced hepatic energy state

effects (rats), 457

prevention of acetaminophen-inducedhepatotoxicity, N-acetyl-L-cysteine

(mice), 54Goldfarb, S., see Weiss, J., 969Goldstein, D. see Brown, J. H., 580Goppelt-Strube, M., see F#{246}rstermann, U.,

352Goto, K., see Saito, 713Grace, A. A. and Bunney, B. S.: Induction

of depolarization block in midbraindopamine neurons by repeated ad-ministration of haloperidol: Analysisusing in vivo intracellular recording,1092

Grandordy, B. M., Cuss, F. M., Sampson, A.S., Palmer, J. B. and Barnes, P. J.:

Phosphatidylinositol response to

cholinergic agonists in airway smoothmuscle: Relationship to contractionand muscaninic receptor occupancy,273

Grant, A. 0., see Moorman, J. R., 159Greenberg, D. A., Carpenter, C. L. and

Messing, R. 0.: Depolarization-de-

pendent binding ofthe calcium chan-nel antagonist, (+)-[3H]PN200-iiO,to intact cultured PC12 cells, 1021

Griffiths, R. R., see Lukas, S. E., 924Gross, G. J. and Daemmgen, J. W.: Benefi-

cia! effects of two specific brady-cardic agents AQ-A39 (Falipamil)and AQ-AH 208 on reversible myo-cardial reperfusion damage in anes-thetized dogs, 422

Gross, G. J., see Eskinder, H., 515Gross, G. J., see Pelc, L. R., 113Grover, G. J., Tierney, M. A. and Weiss, H.

R.: Beta adrenoceptor control of themicrovascular reserve in rabbit myo-cardium, 868

Gruetter, C. A. and Lemke, S. M.: Compar-ison of endothelium-dependent re-laxation in bovine intrapulmonaryartery and vein by acetylcholine and

A23187, 1055

Guentert, T. W., Schmitt, M. and Defoin,R.: Acceleration of the elimination oftenoxicam by cholestyramine in thedog, 295

Gulya, K., Gehlert, D. R., Wamsley, J. K.,Mosberg, H., Hruby, V. J. and Ya-mamura, H. I.: Light microscopic au-toradiographic localization of delta

opioid receptors in the rat brain using

a highly selective bis-pencillaminecyclic enkephalin analog, 720

Gundlach, A. L., see Largent, B. L., 739

Haertzen, C. A., see Kumor, K. M., 960

Hall, G. E. and Kenny, A. D.: Bone resorp-tion induced by parathyroid hormoneand dibutyryl cyclic AMP: Role ofcarbonic anhydrase, 778

Halopenidol, depolarization block induction,midbrain dopamine neurons (rats),1092

Hamed, A. T., Jandhyala, B. S. and Lok-handwala, M. F.: Evaluation of therole of alpha-i and a�pha-2 adre-noceptors in the maintenance of neu-rogenic tone to the hindlimb vascu-lature, 599

Hamon, M., see Bourgoin, S., 360a-hANP, see Human atrial natriuretic poly-

peptide

Hansen, D. K. and Billings, R. E.: Effectsof nitrous oxide on macromolecu!arcontent and DNA synthesis in ratembryos, 985

Hanson, G. R., see Sonsalla, P. K., 932Harris, R. A., see Allan, A. M., 763Harrison, J. H., Jr. and Jollow, D. J.: Role

of aniline metabolites in aniline-in-duced hemolytic anemia, 1045

Harsing, L. G., Jr., see Vizi, E. S., 701Hartley, C. J., see Chelly, J. E., 665Hartmann, A., see Kiil, F., 327Hattori, Y., Nakaya, H., Tohse, N. and

Kanno, M.: Vascular and cardiac ef-fect�s of a new dihydropynidine deriv-ative, YC-170: A comparison withBay K 8644, 670

Haywood, J. R., see Hinojosa, C., 492H2 blocker, pharmacological comparison, ci-

metidine and ranitidine (dogs), 587

Heartantihistamines and local anesthetics, ex-

cess tachycardia (dogs), 367atrial muscle, pharmacodynamic interac-

tions between quinidine and digoxin(guinea pigs), 632

beta adrenoceptor antagonists, antihyper-

tensive effects (rats), 372calcium channel, oNCS-DHP inhibition

of (guinea pig), 1084inotropic and chronotropic actions, dihy-

dropyrides and (rabbits), 670isolated sinoatrial and atrioventricular

nodes, dantrolene sodium, ischemiamodel (rabbits, dogs), 206

stimulation ofmyofilament force, bepridil(pigs), 502

sympathetic function, presynaptic regu-lation (guinea pigs), 447

sympathetic transmission, beta adre-

noceptors, epinephrine and iso-

proterenol effects (dogs), 334Heart muscle, maitotoxin effects (guinea

pigs, rats), 1077Heart rate, vasopressin, sodium-dependent

hypertension and (rats), 492Helgeson, E. A., see Newball, H. H., 839

Hemolytic anemia, aniline-induced, anilinemetabolites role in (rats), 1045

Hepatocytes, exposed to carbon tetrachlo-ride, cytosolic calcium (rats), 186

Hepatotoxicityacetaminophen-induced, glutathione role

in prevention, N-acetyl-L-cysteine(mice), 54

ally! alcohol, liver lobule (rats), 1132, 1138Hess, E. J., Albers, L. J., Le, H. and Creese,

E.: Effects of chronic SCH23390

treatment on the biochemical and be-havioral properties of D1 and D2 do-pamine receptors: Potentiated be-havioral responses to a D2 dopamineagonist after selective D1 dopaminereceptor upregulation, 846

Hexobarbital hydroxylase, hepatic monoox-ygenase system, persistent defects,

phenytoin (rats), 68High, J., see Antonaccio, M. J., 378Hindlimb, resistance, alpha adrenoceptors

and (dogs), 599Hinojosa, C. and Haywood, J. R.: Develop-

ment of high sodium renal hypenten-sion during chronic blockade of thevascular effects of vasopressin, 492

Hinson, J. A. and Mays, J. B.: Covalentbinding of the phenacetin metabolitep-nitrosophenetole to protein, 106

Hippocampusbarbiturate effects (rats), 564membranes, serotonin inhibition, forsko-

lin-stimulated adenylate cyclase

(guinea pigs, rats), 248Histamines

local anesthetics and, excess tachycardia(dogs), 367

lung mediator release, reduced oxygentension, 8

release, organophosphate-induced, mastcells (rats), 839

Hoffer, B., see Contreras, P. C., 1101Hoffman, B. B., see Rosenbaum, J. S., 396Hoffmann, I. S., Talmaciu, R. K. and Cu-

beddu, L. X.:Interactions betweenendogenous dopamine and dopamineagonists at release modulatory recep-tars: Multiple effects of neuronal up-take inhibitors on transmitter re-lease, 437

Holck, M., see Kozlowski, R., 1084

Holthe, M. R., see Ku!, F., 327Holtzman, S. G., see Finn, I. B., 542Holtzman, S. G., see Locke, K. W., 990,997Hori, R., see Saito, H., 1071

Hosobuchi, Y., see Gilbeau, P. M., 974Hruby, V. J., see Gulya, K., 720Hubel, K. A. and Renquist, K. S.: Effect of

neuropeptide Y on ion transport bythe rabbit ileum, 167

Huffman, W., see Mann, W. A., 401a-Human atnial natriuretic polypeptide,

synthetic, tubular site of action(dogs), 707

Hydralazine, regional blood flow and, con-scious state (dogs), 665

Hydronephrotic cortical interstitial cellseicosanoid synthesis (rabbits), 95prostaglandin E, synthesis, verapamil ef-

fect (rabbits), 125

i2-Hydroxyeicosatetraenoic acid, insulin re-lease and, pancreatic islets (rats), 809

P-Hydroxymercunibenzoic acid, insulin re-lease and, pancreatic islets (rats),809, 819

3-Hydroxy-3-methylglutaryl conezyme Areductase, ketoconazole effects,

sterol synthesis, 9055-Hydroxytryptamine, see Serotonin

Hynes, M. R., Banner, W., Jr., Yamamura,H. I. and Duckles, S. P.: Characteri-

zation of muscarmnic receptors of therabbit ear artery smooth muscle andendothelium, 100

1986 Index 1151

Hypercalcemia, experimental, WR-2721 ef-fects (rats), 969

Hyperserotoninemia, gastrointestinal ef-fects, ketanserin, atropine, and meth-ysergide in (dogs), 536

Hypertension

beta adrenoceptor antagonists, antihyper-

tensive effects (rats), 372one-kidney, figure-8, vasopressin and

(rats), 492pheochromocytoma, aortic contraction in

(rats), 396spontaneous, carbocyclic adenosine in

(rats), 954Hypoxia

chemotactic factor-induced transcutane-ous, ibuprofen and methylpredniso-

lone effects (rabbits), 453lung mediator release, 8

Ibuprofen, chemotactic factor-induced

transcutaneous hypoxia and (rab-bits), 453

IC! 174864, opioid agonist activity of (mice),769

Ileumcalcium channel, oNCS-DHP inhibition

of (guinea pig), 1084

CH-38083 effects (guinea pigs), 701neuropeptide Y, effect on ion transport

(rabbits), 167

opioid agonist activity (guinea pigs), 625Imipramine, injected into amygdala, behav-

ioral responses and (rats), 758Indomethacin

milrinone inhibition of, lung (guineapigs), 874

water excretion and, kidney, 653Inotropic actions, desethyl-N-acetylpro-

cainamide (dogs), 893Insulin

release, p-hydroxymercuribenzoic acid ef-fects, islets (rats), 809

urinary eicosanoid excretion and, experi-mental diabetes (rats), 606

Intestinal motilitycholinergic neuron mediation of (rats),

594nervous control of (guinea pigs), 1114

Inui, K.-!., see Saito, H., 1071

Iodocyanopindolol, beta adrenergic recep-tars, radioligand selectivity, quanti-

tative analysis, 46Iodohydroxybenzylpindolol, beta adrenergic

receptors, radioligand selectivity,

quantitative analysis, 46lodopindolol, beta adrenergic receptors,

radioligand selectivity, quantitativeanalysis, 46

Iprindole, injected into amygdala, behav-ioral responses and (rats), 758

IPS-339, epinephrine and isoproterenol,sympathetic transmission, heart(dogs), 334

Ischemia, isolated sinoatrial and atrioven-tricular nodes, dantrolene sodium,

electrophysiological actions (rabbits,

dogs), 206Ishikawa, T., see Saito, A., 713

Isoproterenolepinephrine and IPS-339, sympathetic

transmission, heart (dogs), 334stimulation of fat cells, cyclic AMP and

lipolysis relations in (rats), 659

verapamil and prostaglandin E�, airway

smooth muscle relaxation (dogs), 76o-Isothiocyanate dihydropynidine, calcium

channel inhibition (guinea pig), 1084

Ito, K., see Yukimura, T., 707

Iyengar, S., Kim, H. S. and Wood, P. L.:

Kappa opiate agonists modulate thehypothalamic-pituitary-adrenocorti-cal axis in the rat, 429

Iyengar, S., see Rinehart, R. K., 178

Jacobson, A. E., see Contreras, P. C., 1101Jaffe, B. M., Ferrara, A. and Sherlock, D.

J.: Comparative effects of ketanserin,atropine and methysergide on thegastrointestinal effects of hypersero-toninemia in the awake dog, 536

Jalife, J., see Davidenko, J., 206James, D. W., see Ward, S. J., 625

James, M. 0., see Shiverick, K. T., 1108

Jandhyala, B.S., see Hamed, A. T., 599Jardine, I., see Low, J. E., 39Jasinski, D., see Kumor, K. M., 960Jaw-opening reflex, -nociceptive, alpha ad-

renoceptor modulation of (rats, rab-bits), 576

Jejunum, contractility, after chronic abla-tion, myenteric plexus (rats), 372

Jim, K. F., Macia, R. A. and Matthews, W.D.: Role of receptor reserve in the

inhibition of alpha-i adrenoceptor-

mediated pressor responses by cal-cium antagonists in the pithed rat, 89

Johnson, J. D., see Solaro, R. J., 502

Johnson, K. M., see Snell, L. D., 938

Johnson, M. D., Wang, J. K. T., Morgan, J.I. and Spector, S.: Downregulation of[3H]RO5-4864 binding sites after ex-posure to peripheral-type benzodi-azepines in vitro, 855

Johnson, R. E., see Kumor, K. M., 960

Johnson, S., see Contreras, P. C., llOiJollow, D. J., see Harrison, J. J., Jr., 1045Jones, M. E., see Meffin, P. J., 280Jones, M. E., Sallustio, B. C., Purdie, Y. J.

and Meffin, P. J.: Enantioselectivedisposition of 2-arylpropionic acidnonsteroidal anti-inflammatorydrugs. II. 2-Phenylpropionic acid pro-tein binding, 288

Josepovitz, C., see Ramsammy, L. S., 83Joshi, U., see Atchison, W. D., 618

Kalivas, P. W., Richardson-Carlson, R andDuffy, T.: Neuromedin N mimics theactions of neurotensin in the ventraltegmental area but not in the nucleusaccumbens, 1126

Kal!ikreinrenal, segmental nephron function, apro-

tinin treatment (rats), 155urinary, experimental diabetes mellitus

and (rats), 606

Kaloyanides, G. J., see Ramsammy, L. S.,83

Kanda, A., see Yorikane, R., 334Kangawa, K., see Yukimura, T., 707Kanno, M., see Hattoni, Y., 670

Kaplan, H. R., see Ryan, M. J., 473Kapocsi, J., see Vizi, E. S., 701Katona, P. G., see Rigel, D. F., 367Katz, L. B., Scott, C. K. and Shriver, D. A.:

Pharmacological comparison of ORF

17910, a potent, long-acting hista-

mine H2-receptor agonist, to cimeti-dine and ranitidine, 587

Kau, S. T., see Li, J. H.-Y., 415Kauffman, F. C., see Bath, M. Z., 1138Kauffman, F. C., see Belinsky, S. A., 7835Kauker, M. L. and Nasjletti, A.: Segmental

nephron function in rats treated withaprotinin, an inhibitor of kallikrein,i55

KB-944, novel calcium antagonist, myocar-dial ischemia (dogs), 113

Kelatorphan, release of methionine-en-

kephalin-like material, spinal cord(rats), 360

Kenny, A. D., see Hall, G. E., 778Ketanserin

alpha-2 adrenoceptors, question of exist-ence, tail arteries (rats), 267

gastrointestinal effects of hyperserotoni-nemia and (dogs), 536

Ketoconazole, cholesterol synthesis and,

905

Ketocyclazocine, psychopharmacology of,960

Kiang, J. G., see Wei, E. T., 783

Kidney

cells, anoxia, calmodulin binding drugs(rabbits), 119

circulation, hydralazine effects, conscious

state (dogs), 665cortex, lipid peroxidation, gentamicin-in-

duced (rats), 83drug metabolism, chemical carcinogenesis

(rats), 457epithelial cell, gentamicin transport, 1071failure, pharmacokinetics of diflunisal

(rats), 978hemodynamics

carbocyclic adenosine in (rats), 954

a-hANP site of action (dogs), 707

prostaglandin B2 synthesis, verapamil ef-feet, hydronephrotic cortical intersti-

tial cells (rabbits), 125segmental nephron function, aprotinin

treatment (rats), 155sodium/potassium-ATPase, transport

rate, transcellular NaCl reabsorption(dogs), 327

tubules, bumetanide action in (mice), 407Xii!, F., Hartmann, A., Langberg, H., Se-

jersted, 0. M. and Holthe, M. R:Renal Na,K-adenosine triphospha-tase transport rate limits transcel!u-lar NaCI reabsorption in distal neph-rons of volume-expanded dogs, 327

Killam, E. K., see Paule, M. G., 32Kim, H. S., see Iyengar, S., 429Kimura, S., see Saito, A., 713Kimura, T., see Yorikane, R, 334

King, L. W., see Lertora, J. J. L., 893Kinins, segmental nephron function, apro-

tinin treatment (rats), 155Kinter, L. B., see Mann, W. A., 401Klaassen, C. D., see Dulls, R. L, 463Klemfuss, H. and Adler, M. W.: Autonomic

mechanisms for morphine and am-phetamine mydriasis in the rat, 788

Kobayashi, M., Kondo, S., Yasumoto, T.and Ohizumi, Y.: Cardiotoxic effectsof maitotoxin, a principal toxin ofseafood poisoning, on guinea pig andrat cardiac muscle, 1077

Kocher, T., see Kumor, K. M., 960Kondo, S., see Kobayashi, M., 1077

Koslo, R. J., Burks, T. F. and Porreca, F.:

1152 Index Vol. 238

Centrally administered bombesin a!-fects gastrointestinal transit and co-lonic bead expulsion through supra-spinal mechanisms, 62

Kosobud, A. and Crabbe, J. C.: Ethanolwithdrawal in mice bred to be genet-ically prone or resistant to ethanolwithdrawal seizures, 170

Kozlowski, R., Ehrhard, P., Fischli, W., Os-terrieder, W. and Holck, M.: o-Iso-thiocyanate dihydropynidine (oNCS-DHP), a long-acting reversible inhib-itor of the Ca� channel, 1084

Kraemer, F. B. and Spilman, S. D.: Effectsof ketoconazole in cholesterol syn-thesis, 905

Kragh, R., see Carroll, M. E., 1Kroeger, E. A., see Bergen, J., 679

Kumor, K. M., Haertzen, C. A., Johnson, R.E., Kocher, T. and Jasinski, D.: Hu-man psychopharmacology of ketocy-

clazocine as compared with cyclazo-cine, morphine and placebo, 960

Kwang, J. K. T., see Johnson, M. D., 855

Lac, S. T., see Carroll, M. E., 1Lai, W. S., see El-Fakahany, E. E., 554Lakshmi, V. M., see Spry, L., 457Lambert, C., Vermeulen, M., Cardinal, R.

and Nadeau, R.: Effect of the induc-tion of amiodarone biotransforma-tion on ventricular refractory periods

in rats, 307Lane, B. P., see Ramsammy, L. S., 83Langberg, H., see Kiil, F., 327Lanosterol, synthesis, ketoconazole effects,

905Largent, B. L., Gundlach, A. L. and Snyder,

S. H.: Pharmacological and autora-diographic discrimination of sigmaand phencyclidine receptor bindingsites in brain, with (+)-[3H]SKF10,047, (+)-[3HJ-3-[3-hydroxy-

phenylj-N-(1-propyl)piperidine and[3HJ-1-[1-(2-thienyl)cyclohexyljpi-peridine, 739

Larrey, D., see Letteron, P., 685Le, H., see Hess, E. J., 846Le Bars, D., see Bourgoin, S., 360Loch, G. M., see Shapiro, B. H., 68Lee, N. M., see Fang, F. G., 1039Lee, N. M., see Gilbeau, P. M., 974Leibold, L., see Picker, M., 529Lemke, S. M., see Gruetter, C. A., 1055Lepore, R. D., see Perrone, M. H., 389Lertora, J. J. L. and King, L. W.: Cardio-

vascular actions and pharmacoki-

netics of desethyl-N-acetylprocain-amide in the dog, 893

Lessor, R. A., see Contreras, P. C., 1101Letteron, P., Descatoire, V., Larrey, D., Ti-

nel, M., Geneve, J. and Pessayre, D.:

Inactivation and induction of cyto-chrome P-450 by various psoralen de-rivatives in rats, 685

Leukocyteschloroquine, mechanisms of cell associa-

tion, 302polymorphonuclear, oxygen metabolite

generation, doxorubicin and doxo-rubicinol-induced alterations, 19

Leukotrienes, lung mediator release, re-

duced oxygen tension, 8Levitt, B. and Duckles, S. P.: Evidence

against serotonin as a vasoconstric-

tor neurotransmitter in the rabbitbasilar artery, 880

Li, J. H.-Y., Zuzack, J. S. and Kau, S.T.:Effects of detergents on sodium

transport in toad urinary bladder,415

Liang, B. T. and Molinoff, P. B.: Beta ad-renergic receptor subtypes in theatria: Evidence for close coupling ofbeta-i and beta-2 adrenergic recep-tors to adenylate cyclase, 886

Lichtenstein, L. M., see Peters, S. P., 8Lidocaine, pH potentiation, drug pK, so-

chum channel blockade in ventricular

myocardium (guinea pigs), 159Lin, J. H., Ulm, E. H. and Duggan, D. E.:

Possible mechanisms for reduced

plasma clearance of diflunisal in ratexperimental renal failure, 978

Ling, K.-Y., see Ramsammy, L. S., 83Lipid peroxides, hepatotoxicity and, liver

lobule (rats), 1138

Lipids, peroxidation and toxicity, gentami-cm-induced, diphenyl-phenylenedi-

amine effects (rats), 83Lipolysis, cyclic AMP relations, fat cells,

isoproterenol and forskolin effects(rats), 659

Liposomes, novel cyclosporine binding as-say (mice), 39

Lipoxygenase

insulin release and, pancreatic islets(rats), 809

stimulus-secretion coupling, insulin re-lease and (rats), 819

Liverhepatotoxicity, allyl alcohol (rats), 1132,

1138

monooxygenase system, persistent de-fects, phenytoin (rats), 68

Locke, K. W. and Holtzman, S. G.: Behav-ioral effects of opioid peptides selec-tive for mu or delta receptors. I. Mor-phine-like discriminative stimuluseffects, 990

Locke, K. W. and Holtzman, S. G.: Behav-ioral effects of opioid peptides selec-tive for mu or delta receptors. II. Lo-comotor activity in nondependentand morphine-dependent rats, 997

Locomotor activity

chronic SCH23390, dopamine receptors

and (rats), 846

opioid peptide effects (rats), 990,997stimulation, caffeine and (rats), 542

Lokhandwala, M. F., see Alkadhi, K. A., 547

Lokhandwala, M. F., see Hamed, A. T., 599London, E. D., see Szikszay, M., 192Long, R. M. and Moore, L: Elevated cyto-

solic calcium in rat hepatocytes ex-posed to carbon tetrachloride, 186

Longhurst, P. A. and Belis, J. A.: Abnor-malities of rat bladder contractilityin streptozotocin-induced diabetesmellitus, 773

LoPresti, D., see Ward, S. J., 625Low, J. E. and Jardine, I.: A novel cyclo-

sporine binding assay, 39Lucchesi, B. R., see Simpson, P. J., 497Lukas, S. E., Brady, J. V. and Griffiths, R

R.: Comparison of opioid seif-injec-tion and disruption of schedule-con-trolled performance in the baboon,924

Lund, D. D., see Schmid, P. G., 447

Lungangiotensin-converting enzyme inhibitor,

uptake of N-[i(S)-carboxy-(4-OH-3-‘�I-phenyl)ethyl-L-ala-L-pro (rab-bits), 14

mediator release, reduced oxygen tension,8

milrinone effects, contractile response(guinea pigs), 874

Luteinizing hormone

naloxone effects on, hyposensitivity to,male (rats), 1063

6-9-tetrahydrocannabinol treatment ef-fects, chronic prepuberta! treatmentof female (rats), 1034

Ly 171555, supersensitivity, apomorphine,rotational behavior (mice), 242

LY 281217, carboxypeptidase degradation

product, opioid agonist activity of IC!174864 (mice), 769

LY83583, carbachol and forskolin interac-

tion, isolated cardiac preparations(rabbits), 313

Lysergic acid diethylamide, serotonin inhi-bition, forskolin-stimulated adenyl-ate cyclase, hippocampal membranes(guinea pigs, rats), 248

Lysolecithin acyltransferase, acyl-coenzyme

A inhibitors, endothelium-derivedvascular relaxing factor (rabbits), 352

Lysophosphatidylcholine, stimulus-secre-tion coupling and, insulin release, is-lets (rats), 819

Lysophospholipidsinsulin release and, pancreatic islets

(rats), 809

stimulus-secretion coupling and, insulin

release, pancreatic islets (rats), 819

Maayani, S., see De Vivo, M., 248Macdonald, R. L., see McLean, M. J., 727Macia, R. A., see Jim, K. F., 89MacLeod, K. M. and Diamond, J.: Effects

of the cyclic GMP lowering agentLY83583 on the interaction of car-bachol with forskolin in rabbit iso-lated cardiac preparations, 313

Macromolecular synthesis, nitrous oxide ef-

feds, embryos (rats), 985

Maderazo, E. G., Breaux, S. P. and Woron-

ick, C. L.: Protective effects of ibu-profen and methylprednisolone onchemotactic factor-induced transcu-taneous hypoxia, 453

Maggi, C. A., Giuliani, S., Manzini, S., San-

ticioli, P. and Meli, A.: Motor effectof neurokinins on the rat duodenum:Evidence for the involvement of sub-stance K and substance P receptors,341

Maggi, C. A., Santicioli, P., Giuliani, S.,

Regoli, D. and Meli, A.: Activation ofmicturition reflex by substance P and

substance K: Indirect evidence forthe existence of multiple tachykininreceptors in the rat urinary bladder,259

Maitotoxin, cardiotoxic effects, cardiacmuscle (guinea pigs, rats), 1077

Major, T. C., see Ryan, M. J., 473Makman, M. H., see Cubells, J. F., 508

Mann, W. A., Stassen, F., Huffman, W. andKinter, L. B.: Mechanism of actionand structural requirements of vaso-pressin analog inhibition of trans-

1986 Index 1153

epithelial water flux in toad urinary

bladder, 401

Mansbach, R. S., see Barrett, J. E., 1009Manzini, S., see Maggi, C. A., 341Marley, R. J., Miner, L. L., Wehner, J. M.

and Collins, A. C.: Differential effectsof central nervous system depres-

sants in long-sleep and short-sleepmice, 1028

Marwah, J., see Curtis, A. L., 576Marwood, J. F., Chapman, K. L. and Stokes,

G. S.: Studies that question the exist-

ence of a4,ha-2 adrenoceptors in tailarteries of normotensive Sprague-

Dawley rats, 267Masaki, T., see Saito, A., 713

Mason, N., see Cohen, M. L., 860Mast cells, histamine release, organophos-

phate-induced (rats), 839

Mathias, N. P., see Ryan, M. J., 473Matsuo, H., see Yukimura, T., 707Matthews, W. D., see Jim, K. F., 89Mattila, J. and Bu#{241}ag,R. D.: Sympathetic

vasoconstriction and renin secretion

cause pressor responses to thyrotro-

pin-releasing hormone in rats, 232

Mayersohn, M., see Woodworth, J. R., 900Mays, J. B., see Hinson, J. A., 106McCall, D. E., see Chiu, A. T., 224McDonough, P. M., Wetzel, G. T. and

Brown, J. H.: Further characteriza-tion ofthe presynaptic alpha-i recep-

tar modulating [3HJACh release fromrat atnia, 612

McGiff, J. C., see Quilley, J., 606

McGonigle, P., see Neve, K. A., 46McLean, M. J. and Macdonald, R. L.: Car-

bamazepine and 10,11-epoxycarba-

mazepine produce use- and voltage-dependent limitation of rapidly firingaction potentials of mouse centralneurons in cell culture, 727

Meffin, P. J., Sallustio, B. C., Purdie, Y. J.and Jones, M. E.: Enantioselectivedisposition of 2-arylpropionic acid

nonsteroidal anti-inflammatory

drugs. I. 2-Phenylpropionic acid dis-position, 280

Meffin, P. J., see Jones, M. E., 288Meli, A., see Maggi, C. A., 259, 341Mertz, T. E., see Ryan, M. J., 473Messing, R. 0., see Greenberg, D. A., 1021Metabolic/excretory coupling, renal, nitro-

furothiazole carcinogens (rats), 457

Metaphit, acy!ating ligand for receptors(rats), 1101

Met-enkephalin, release, kelatorphan,spinal cord (rats), 360

Methamphetamine, dopamine receptor sub-types in, monoamine systems (rats),

932Methionine synthetase, nitrous oxide anes-

thesia effects, embryos (rats), 985

N-Methyl-D-aspartate, phencyclidine and,striatum (rats), 938

3-Methylcholanthrene, placental activityand (rats), 1108

Methylmercury, block, end-plate potential(rats), 618

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyri-dine, reactive metabolite, brain(rats), 648

Methylprednisolone, chemotactic factor-in-duced transcutaneous hypoxia and(rabbits), 453

N-Methylscopolaminecardiac muscarinic receptors (chicks), 580multiple binding affinities, brain muses-

rime acetylcboline receptors (rats),554

Methylxanthines, caffeine, locomotor activ-

ity and (rats), 542Methysergide, gastrointestinal effects of hy-

perserotoninemia and (dogs), 536Metz, S. A.: p-Hydroxymercuribenzoic acid

inhibits arachidonic acid esterifica-tion in two distinct pools and stimu-lates insulin release in intact rat is-lets, 809

Metz, S. A.: Putative roles for lysophospho-lipids as mediators and lipoxygenase-mediated metabolites of arachidonic

acid as potentiators of stimulus-se-cretion coupling Dual mechanismsof p-hydroxymercunibenzoic acid-in-duced insulin release, 819

Meyer, E. R., see Cicero, T. J., 1063Microvascular reserve, myocardium, beta

adrenoceptor control of(rabbits), 868Migrating myoelectric complex, gastrointes-

tins!, nervous control of (guinea

pigs), 1114Miller, B. T., see Cicero, T. J., 1063Miller, T. B., see Smith, E. R., 26Mills, E., Bruckert, J. W. and Smith, P. G.:

Development of adrenergic and non-adrenergic pressor mechanisms inrats sympathectomized from birth,1014

Milnor, W. R.: Limitations of Schild plotsin a two-receptor system: Alpha adre-noceptors of vascular smooth muscle,237

Milrinone, contractile response and, lung(guinea pigs), 874

Miner, L. L., see Marley, R. J., 1028

Miyazaki, M., see Teds, N., 319Molinoff, P. B., see Liang, B. T., 886Molinoff, P. B., see Neve, K. A., 46Monoamine oxidase, formation of 1-methyl-

4-phenyl-1,2,3,6-tetrahydropyridine,brain (rats), 648

Monohydroxy metabolites, phencycidine,disposition kinetics (dogs), 900

Monooxygenase, hepatic system, persistentdefects, phenytoin (rats), 68

Moore, D. H., Abel, P. W., Rinard, G. A.,Puckett, A. M. and Walter, J. B.:Regional differences in relaxation ofelectric field-stimulated canine air-way smooth muscle by verapamil, iso-proterenol and prostaglandin E,, 76

Moore, L, see Long, R. M., 186

Moorman, J. R., Yes, R., Bjornsson, T.,Starmer, C. F., Grant, A. 0. andStrauss, H. C.: pI( does not predictpH potentiation of sodium channelblockade by lidocaine and W6211 inguinea pig ventricular myocardium,159

Morgan, J. I., see Johnson, M. D., 855Morphine

mydriasis, mechanism (rats), 788

neurogenic plasma extravasation and,paw (rats), 783

psychopharmacology of ketocyclazocinecompared with, 960

verapamil interactions, calcium antago-nists, physiological parameters(rats), 192

Mosberg, H., see Gulya, K., 720Mueller, R. A., see Duncan, G. E., 758Murray, D. L., see Stupecky, G. L., 802Muscarinic receptors, see Receptors

Muscle, smoothairway

adrenoceptor-mediated mechanical ne-sponse (dogs), 679

phosphatidylinositol response, cholin-ergic agonists (cattle), 273

relaxation, verapamil, isoproterenol

and prostaglandin E� (dogs), 76aortic, contraction, desensitization of,

pbeochromocytoma and (rats), 396

ear artery and endothelium, muscaninicreceptors, characterization (rabbits),100

vascularalpha-1,2 adrenoceptors, effect of cool-

ing (dogs), 139alpha adrenoceptors, Schild plot limi-

tations, 237alpha-i and alpha-2 adrenoceptors, re-

sponse coupling (dogs), 131Mydniasis, morphine and amphetamine,

autonomic mechanisms (rats), 788

Myenteric plexus, after chronic ablation, je-junal contractility (rats), 372

Myocardiumisehemia

beneficial effects of bradycardic agents,anesthesia and (dogs), 422

novel calcium antagonist (dogs), 113microvascular reserve, beta adrenoceptor

control of (rabbits), 868ventricular, sodium channel blockade,

drug pI(. and pH potentiation(guinea pigs), 159

Myofilaments, cardiac, stimulation by be-pridil (pigs), 502

Nadeau, R., see Lambert, C., 307

Nakaki, T., see Roth, B. L., 480Nakaya, H., see Hattori, Y., 670Naloxone, opiate withdrawal-induced by-

posensitivity, serum luteinizing hor-mone, male (rats), 1063

Naltrexoneeffects, cocaine self-injection (rats), 1opioid peptide antagonism (rats), 990,997

Naseer, K., see Allen, D. 0., 659

Nasjletti, A., see Kauker, M. L., 155Neale, R. F., see Rinehart, R. K., 178Nephrectomy, sympathetic vasoconstriction

and renin secretion, pressor re-sponses, thyrotropin-releasing hor-mone (rats), 232

Nephrons, distal, renal sodium/potassium-ATPase transport rate, NaCl reab-sorption (dogs), 327

Nerve terminals, calcium entry, suppressionby methylmercury (rats), 618

Neuroblastoma cells, muscarinic cholinergicreceptors in, short-term desensitiza-tion (mice), 916

Neurogenic inflammation, corticotropin-re-leasing factor and, paw (rats), 783

Neurogenic tone, hindlimb vasculature, a!-p1w adrenoceptors and (dogs), 599

Neurokinins, motoreffect, duodenum (rats),341

Neuromedin N, ventral tegmental area,1126

Neuromuscular transmission, methyhner-

1154 Index Vol. 238

cury inhibition of, nerve terminals

(rats), 618Neurons, central, reduction of repetitive fir-

ing by carbamazepine (mice), 727

Neuropeptides, peripheral, intestinal my-

oelectric activity (guinea pigs), 1114Neuropeptide Y, effect on ion transport,

ileum (rabbits), 167Neurotensin, actions, ventral tegmental

area, 1126Neurotransmission

sympatheticbeta adrenoceptors, cardiovascular re-

sponsiveness (rats), 148beta adrenoceptors, heart (dogs), 334

Neurotransmittersrelease, presynaptic alpha-i receptor

modulation of, atria (rats), 612vasoconstrictor, basilar artery (rabbits),

880

Neutrophils, stimulated, ibuprofen and,

complications (rabbits), 453Neve, K. A., McGonigle, P. and Molinoff,

P. B.: Quantitative analysis of theselectivity of radioligands for sub-types of beta adrenergic receptors, 46

Newball, H. H., Donlon, M. A., Procell, L.R, Helgeson, E. A. and Franz, D. R.:Organophosphate-induced histaminerelease from mast cells, 839

Newman, T., see Carroll, M. E., 1Nicotine

jejunal contractility, after chronic abla-tion, myenteric plexus (rats), 372

stimulatory effects, rapid desensitization

of, plasma adrenocorticotropin and

prolactin (rats), 486Nielson, C. P., Brenner, D. and Olson, R.

D.: Doxorubicin and doxorubicinol-induced alterations in human poly-morphonuclear leukocyte oxygen me-

tabolite generation, 19Nies, A. S., see Schwertschlag, U., 653Nifedipine, receptor reserve and calcium an-

tagonists, alpha-i adrenoceptors(rats), 89

Nitrendipine, serotonin contraction and,uterus and jugular vein (rats), 860

5-Nitrofuran carcinogens, metabolism,bladder (rats), 457

Nitrofurothiazole carcinogens, metabolism,

bladder (rats), 457Nitroglycerin, block, alpha-2 adrenoceptors

(dogs), 515p-Nitrosophenetole, covalent binding to

protein (rats, mice), 106Nitrous oxide, macromolecular content and

DNA synthesis, embryos (rats), 985

Nociception, jaw-opening reflex, alpha ad-renoceptor modulation of (rats, rab-bits), 576

Nomifensine, drug interactions, autorecep-tore (rabbits), 437

Nonsteroidal anti-inflammatory drugs,water excretion and, kidney, 653

Nordihydroguaiaretic acid, endothelium-de-rived relaxing factor, acyl-coenzymeA:lysolecithin acyltransferase inhib-itors (rabbits), 352

Norepinephrinealpha-1,2 adrenoceptors, effect of cooling,

saphenous and femoral veins (dogs),

139Schild plot limitations, alpha adrenocep-

tors, vascular smooth muscle, 237

turnover, CH-38083 effects (guinea pigs,rats, mice), 701

Nucleus accumbens, neuromedin N actions,1126

Oates, R., see Davidenko, J., 206Obesity, verapamil dynamics and (rats), 642Ode, R. P., see Schmid, P. G., 447O’Donohue, T. L., see Contreras, P. C., 1101Ohiztimi, Y., see Kobayashi, M., 1077

Okamoto, M, Rao, S. and Walewski, J. L.:Effect of dosing frequency on the de-velopment of physical dependenceand tolerance to pentobarbital, 1004

Okamura, T., see Toda, N., 319Olsen, K., see Contreras, P. C., 1101Olsen, R. W., see Dunwiddie, C. W., 564Olson, R. D., see Nielson, C. P., 19Olszewski, B. J., see Ryan, M. J., 473Operant conditioning, anticonvulsant

drugs, modulation by external dis-

criminative stimulus (pigeons), 529Opiates

hypothalamic-pituitary-adrenal axis and(rats), 429

neuroendocrine, anterior pituitary hor-mones (primate), 974

supraspinal analgesic effects, mu receptoraction (mice), 1039

withdrawal-induced hyposensitivity, nal-oxone, serum LH, male (rats), 1063

Opioid, self-injection, disruption of sched-ule-controlled performance and (ha-boons), 924

Opioid agonistsactivity of IC! 174864 (mice), 769mu- and delta-selective, ileal preparation

and (guinea pigs), 625neurogenic plasma extravasation and,

paw (rats), 783

Opioid peptidesbehavioral effects

morphine-like, 997

mu and delta receptors (rats), 990ORF 17910, pharmacological comparison,

cimetidine and ranitidine (dogs), 587Organophosphate, histamine release in-

duced by, mast cells (rats), 839

Osborne, J. J., see Cohen, M. L., 769Osterrieder, W., see Kozlowski, R., 1084

Ouabainprostatic secretion, drug-modified ion

transport (dogs), 26renal sodium/potassium-ATPase trans-

port rate, tnansce!lu!ar NaCl reab-sorption (dogs), 327

Owens, S. M., see Woodworth, J. R., 900

Palermo, N. J., see Smith, E. R., 26Palmer, J. B., see Grandordy, B. M., 273Palmier, M. 0., see Danon, A., 95Pancreatic islets, insulin release, p-hydrox-

ymercuribenzoic acid-induced (rats),809, 819

Paraldehyde, central nervous system de-pressant, long- and short-sleep(mice), 1028

Parathyroid hormone, bone resorption in-duced by (mice), 778

Paule, M. G. and Killam, E. K.: Behavioraltoxicity of chronic ethosuximide andsodium valproate treatment in theepileptic baboon, Papio papio, 32

PC12 cells, depolarization-dependent bind-ing, calcium channelantagonist, 1021

Peeters, P. A. M., see Raghoebar, M., 302

Pelc, L. R., Gross, G. J. and Warltier, D. C.:Effects of KB-944, a novel calciumantagonist, in several models of ca-nine myocardial ischemia, 113

Penney, J. B., Jr., see Ciliax, B. J., 749Pentobarbital, dependence and tolerance,

dosing frequency (cats), 1004

Peptidase, kelatorphan and, Met-enkepha-lin-like release, spinalcord (rats), 360

Perrone, M. H., Lepore, R. D. and Sham,W.: Identification and characteriza-tion of substance P receptors onLRM55 glial cells, 389

Pessayre, D., see Letteron, P., 685Peters, S. P., Lichtenstein, L. M. and Ad-

kinson, N. F., Jr.: Mediator releasefrom human lung under conditions of

reduced oxygen tension, 8Petrack, B., see Rinehart, R. K., 178

pH, potentiation, drug pK�, sodium channelblockade in ventricular myocardium(guinea pigs), 159

Pharmacokinetics, diflunisal, renal failure

(rats), 978Phenacetin, metabolite, covalent binding to

protein (rats, mice), 106Phencyclidine

receptors, see Receptors

excitatory amino acids and, stniatum(rats), 938

monohydroxy metabolites of, dispositionkinetics (dogs), 900

p-Phenetidine, covalent binding to protein(rats, mice), 106

Phenobarbita!, central nervous system de-pressant, long- and short-sleep

(mice), 1028Phenylephnine

a!pha-1,2 adrenoceptors

effect of cooling, saphenous and femo-ral veins (dogs), 139

response coupling, saphenous and fern-oral veins (dogs), 131

alpha-2 adrenoceptors, question of exist-ence, tail arteries (rats), 267

Phenylhydroxylamine, toxicity, hemolyticanemia (rats), 1045

2-Phenylpropionic acid, 2-arylpropionicacid, enantioselective disposition(rabbits), 280, 288

Phenytoinfrequency-dependent actions, Purkinje fi-

bers (dogs), 794hepatic monooxygenase system, persist-

ent defects (rats), 68Pheochromocytoma, aortic smooth muscle

contraction, desensitization of (rats),

396Phorbol esters, phosphoinositide metabo-

lism and, serotonin (rats), 480Phosphatidylinositol, response to cholin-

ergic agonists, airway smooth muscle(cattle), 273

Phosphoinositide, metabolism, phorbol es-ter effects, serotonin (rats), 480

Phospholipase A2, insulin release and, pan-creatic islets (rats), 809

Phospholipase C, phorbol esters and, phos-phoinositide turnover (rats), 480

Physostigmine, jejunal contractility, after

chronic ablation, myenteric plexus(rats), 372

Piccardi, M. P., see Corsini, G. U., 648Picker, M., Leibold, L., Endaley, B. and

1986 Index 1155

Poling, A.: Modulation of the behav-ioral effects of anticonvulsant drugsby an external discriminative stimu-lus in the pigeon, 529

Pimozide, serotonin contraction and, uterusand jugular vein (rats), 860

Pintus, S., see Corsini, G. U., 648Pirenzepine, receptor subtypes, brain, N-

methylscopolamine binding to (rats),554

Pitt, B. R., see Turnin, M., 14Pituitary hormones, anterior, dynorphin

and (primate), 974Placenta

ethoxyresorufin-O-deethylase activity in(rats), 1108

transfer, pharmacokinetic studies, acet-

aminophen disposition (sheep), 198Plasma renin, beta adrenoceptor antago-

fists, antihypertensive effects (rats),372

Plasminogen activator, epithelial tissueevaluation, thrombolytic agent, ye-nous thrombosis (rabbits), 254

Platelets, CGS 13080 effects, coronary ar-tery thrombosis (dogs), 497

Poling, A., see Picker, M., 529Polyaromatics, induction of ethoxyresoru-

fin-O-deethylase, placental tissue(rats), 1108

Porreca, F., see Koslo, R. J., 62Prazosin

alpha- 1,2 adrenoceptors, response cou-pling, saphenous and femoral veins(dogs), 131

alpha-2 adrenoceptors, question of exist-ence, tail arteries (rats), 267

Schild plot limitations, alpha adrenocep-

tars, vascular smooth muscle, 237

sympathetic vasoconstriction and renin

secretion, pressor responses, thyro-

tropin-releasing hormone (rats), 232Prefrontal cortex, dopamine metabolism,

stress-induced increase (rats), 693

Pressor mechanisms, adrenergic and non-adrenergic, sympathectomy and(rats), 1014

Pressure, mean arterial, vasopressin and so-dium-dependent hypertension (rats),492

Presynaptic mechanisms, sympathetic func-tion, cardiac (guinea pigs), 447

Procell, L. R, see Newball, H. H., 839

Prolactindesensitization, stimulatory effects of nic-

otine (rats), 486

tolerance to cannabinoid, suppression of(rats), 1034

Prostaglandin E�bone resorption and (mice), 778verapamil and isoproterenol, airway

smooth muscle relaxation (dogs), 76verapamil effect on synthesis, hydrone-

phrotic cortical interstitial cells (nab-bits), 125

water handling and, kidney, 653Prostaglandins, lung mediator release, re-

duced oxygen tension, 8Prostaglandin system, hydralazine effects

and, regional blood flow, consciousstate (dogs), 665

Prostate, effects on secretion, drugs thatmodify ion transport (dogs), 26

Protein

covalent binding, phenacetin metabolite(rats, mice), 106

extravasation, corticotropin-releasingfactor and, paw (rats), 783

Psoralens, effects on cytochrome P-450

(rats), 685Psychopharmacology, ketocyclazocine, 960Puberty, tolerance to luteinizing hormone

and prolactin, female, #{246}-9-tetrahy-drocannabinol and (rats), 1034

Puckett, A. M., see Moore, D. H., 76Pulmonary circulation, vasoconstriction, a!-

pha-1,2 adrenoceptors, evaluation(dogs), 217

Pulmonary vessles, endothelium-dependentrelaxation, acetylcholine and A23187,1055

Pupil, dilation, morphine and amphetamineeffects (rats), 788

Purdie, Y. J., see Jones, M. E., 288Purdie, Y. J., see Meffin, P. J., 280

Purdy, R. E., see Stupecky, G. L., 802

Purkinje fibers, antiarrhythmic actions of

phenytoin (dogs), 794

Quilley, J. and McGiff, J. C.: Influence ofinsulin on urinary eicosanoid excre-tion in rats with experimental dia-betes mellitus, 606

Quinidine, interactions with digoxin, heartatrial muscle (guinea pigs), 632

Quinpirolechronic SCH23390, dopamine receptors

and (rats), 846dopamine or fenoldopam and, cyclic AMP

levels (rats), 547Quinuclidinyl benzilate

cardiac muscaninic receptors (chicks), 580phosphatidylinositol response, cholin-

ergic agonists, airway smooth muscle(cattle), 273

Radioligands, selectivity, beta adrenergic re-ceptors, quantitative analysis, 46

Rafferty, M. F., see Contreras, P. C., 1101Raghoebar, M., Peeters, P. A. M., van den

Berg, W. B. and van Ginneken, C. A.M.: Mechanisms of cell association ofch!oroquine to leucocytes, 302

Ramkumar, V., see El-Fakahany, E. E., 554Ramsammy, L. S., Josepovitz, C., Ling, K.-

Y., Lane, B. P. and Kaloyanides, G.J.: Effects of diphenyl-phenylenedi-amine on gentamicin-induced lipidperoxidation and toxicity in rat renalcortex, 83

Ranitidine, pharmacological comparison,

H2 blockers (dogs), 587

Rao, S., see Okamoto, M., 1004Rauwolscine, a!pha-i,2 adrenoceptors, re-

sponse coupling, saphenous and fern-oral veins (dogs), 131

Receptor reservealpha-i and 2 adrenoceptors

effect of cooling, saphenous and femo-ral veins (dogs), 139

saphenous and femoral veins (dogs),131

calcium antagonists and, alpha-i adreno-ceptor-mediated pressor responses(rats), 89

Receptorsadenosine, vasodilator effects, sponta-

neous hypertension (rats), 954

alpha

antihypertensive activity of Cl-926(rats), 473

pheochromocytoma, aortic contractionin (rats), 396

threshold synergism, thoracic aorta(rabbits), 802

alpha-iacetylcholine release and, atria (rats),

612antihypertensive activity of Cl-926

(rats), 473pheochromocytoma, aortic contraction

in (rats), 396‘y-aminobutyric acid, barbiturate effects,

brain (mice), 763autoreceptors, dopamine interactions

(rabbits), 437benzodiazepine

antipunishment actions of buspironeand (pigeon), 1009

regulation, imaging (rats), 739beta, to adenylate cyclase, atria (dogs),

886

DA1, activation by dopamine or fenoldo-pam (rats), 547

delta opioid, localization in brain (rats),720

dopamine

D1 and D2, SCH23390 effects (rats), 846

methamphetamine and, monoaminesystems (rats), 932

stress effects, prefrontal cortex (rats),693

mu, supraspinal opiate analgesia (mice),1039

multiple tachykinin, micturition reflex,substance P and K activation (rats),259

muscarinic

brain acetylcholine, N-methylscopo-lamine binding to (rats), 554

cardiac, binding (chicks), 580

ear artery smooth muscle and endothe-hum (rabbits), 100

short-term desensitization, neuroblas-toma cells (mice), 916

opiatecorticosterone and, hypothalamic-pi-

tuitary-adrenal axis (rats), 429mu and delta, discriminative effects

(rats), 990, 997

putative kappa, activity (rats), 833

opioid delta and muagonist activity (mice), 769discriminative effects (rats), 990,997

phencyclidine, acylating ligand for (rats),1101

regulation, flunitrazepam binding (rats),749

Schi!d plot limitationsalpha adrenoceptors, vascular smooth

muscle, 237thoracic aorta (rabbits), 802

serotonincalcium channel antagonists and (rats),

860

phosphoinositide turnover by phorbolesters (rats), 480

thoracic aorta (rabbits), 802

substance P, LRM55 glial cells, 389

vasopressin, vascular, sodium-dependenthypertension and (rats), 492

Reflexes, micturition, substance P and Kactivation, multiple tachykinin re-ceptors (rats), 259

1156 Index Vol. 238

Refractory period, ventricular, inducedamiodarone biotransformation(rats), 307

Regoli, D., see Maggi, C. A., 259Renquist, K. S., see Hubel, K. A., 167Repetitive firing, reduction of, carbamaze-

pine and, central neurons (mice), 727Respiration, interactions between verapa-

mil and morphine, physiological pa-rameters (rats), 192

Respiratory burst, polymorphonuclear leu-kocytes, oxygen metabolite genera-tion, doxorubicin and doxorubicinol-induced alterations, 19

Retina, a-aminobutyric acid enzyme mac-tivation (rats), 508

Rice, K. C., see Contreras, P. C., 1101

Richardson-Carlson, R., see Kalivas, P. W.,1126

Rigel, D. F. and Katona, P. G.: Effects ofantihistamines and local anestheticson excess tachycardia in consciousdogs, 367

Rinard, G. A., see Moore, D. H., 76Rinehart, R. K., Barbaz, B., !yengar, S.,

Ambrose, F., Steel, D. J., Neale, R.F., Petrack, B., Bittiger, H., Wood,P. L. and Williams, M.: Benzodiaze-pine interactions with central thy-roid-releasing hormone binding sites:Characterization and physiologicalsignificance, 178

Rivy, J. P., see Claustre, Y., 693Re 15-1788, antagonism, benzodiazepine-

like drugs (monkeys), 522RO5-4864, 3H-labeled, downregulation of,

peripheral-type benzodiazepines, 855Roques, B. P., see Bourgoin, S., 360

Rosen, M. R., see Spinel!i, W., 794Rosenbaum, J. S., Zera, P., Umans, V. A.,

Ginsburg, R. and Hoffman, B. B.:Desensitization of aortic smoothmuscle contraction in rats harboringpheochromocytoma, 396

Rosenthal, G., see Simpson, P. J., 497Rossing, T. H. and Drazen, J. M.: Effects of

rnilrinone on contractile responses ofguinea pig trachea, lung parenchymaand pulmonary artery, 874

Roth, B. L., Nakaki, T., Chuang, D.-M. andCosta, E.: 5-Hydroxytryptamine2 re-ceptors coupled to phospholipase Cin rat aorta: Modulation of phos-phoinositide turnover by phorbol es-tsr, 480

Rudolph, A. M., see Wang, L. H., 198Ruffolo, R. R., Jr., see Shebuski, R. J., 217

Ryan, J. W., see Turnin, M., 14Ryan, M. J., Bjork, F. A., Cohen, D. M.,

Coughenour, L. L., Major, T. C., Ma-thias, N. P., Marts, T. E., Olszewski,B. J., Singer, R. M., Evans, D. B. andKaplan, H. R.: CI-926 (3-[4-[4-(3-metbylphenyl)-1-piperazinyl]butylj-2,4-imidazolinedione): Antibyperten-sive profile and pharmacology, 473

Sabouni, M. H., see Alkadhi, K. A., 547Saito, A., Ishikawa, T., Masaki, T., Kimura,

S. and Goto, K.: Pharmacologicalanalysis of autonomic innervation ofthe right atria ofrats and guinea pigs:Demonstration of nonadrenergicnoncholinergic nerves, 713

Saito, H., Inui, K.-!. and Honi, R.: Mecha-

nisms ofgentamicin transport in kid-ney epitbe!ial cell line (LLC-PK1),1071

Salhab, A. S., see Shiverick, K. T., 1108

Sallustio, B. C., see Jones, M. E., 288

Sallustio, B. C., see Meffm, P. J., 280

Sampson, A. S., see Grandordy, B. M., 273Santicioli, P., see Maggi, C. A., 259,341

Sapbenous vein, nitroglycerin, blockade ofalpha-2 adrenoceptors (dog), 515

Satoh, S., see Yorikane, R., 334Scatton, B., see Claustre, Y., 693SCH 23390

dopamine or fenoldopam and, cyclic AMPlevels (rats), 547

methamphetamine-induced changes and,

monoamine systems (rats), 932treatment, dopamine receptors and (rats),

846

Schenck, K., see Cohen, M. L., 860Schild plots, limitations, alpha adrenocep-

tors, vascular smooth muscle, 237Schmid, P. G., Whiteis, C. A., Ode, R P.

and Lund, D. D.: Presynaptic regu-lation of cardiac sympathetic func-tion in guinea pigs, 447

Schmitt, M., see Guentert, T. W., 295Schmoeker, P. F., see Cicero, T. J., 1063Schnier, R. W., see Schwertschlag, U., 119Schwartz, D. D. and Eikenburg, D. C.: Car-

diovascular responsiveness to sym-pathetic activation after chronic epi-nephrine administration, 148

Scbwertschlag, U., Gerber, J. G., Barnes, J.S. and Nies, A. S.: A dual effect ofnonsteroidal anti-inflammatory

drugs on renal water handling in hu-mans, 653

Schwertschlag, U., Schrier, R W. and Wil-son, P.: Beneficial effects of calciumchannel blockers and CaImOdUlin

binding drugs on in vitro renal cellanoxia, 119

Scott, C. see Katz, L B., 587Sedative hypnotics, long- and short-sleep

with (mice), 1028

Sejersted, 0. M., see Kiil, F., 327Serotonergic system, methamphetamine-in-

duced changes, dopamine receptor

sybtypes in (rats), 932Serotonin

as a vasoconstrictor neurotransmitter,basilar artery (rabbits), 880

forskolin-stimulated adenylate cyclase,receptor-mediated inhibition, hippo-campal membranes (guinea pigs,rats), 248

phosphoinositide turnover, phorbol ester

and (rats), 480receptor activation, calcium ion channel

antagonists and (rats), 860

Sexual dimorphism, hepatic monooxygen-ase system, persistent defects, pbe-nytoin (rats), 68

Sham, see Perrone, M. H., 389Shapiro, B. H., Lech, G. M. and Bardales,

R. M.: Persistent defects in the he-

patic monooxygenase system of adultrats exposed, perinatally, to mater-nally administered phenytoin, 68

Sharp, B. M. and Beyer, H. S.: Rapid desen-sitization ofthe acute stimulatory ef-

fects of nicotine on rat plasma adre-nocorticotropin and prolactin, 486

Shebuski, R. J., Fujita, T. and Ruffolo, R.

R., Jr.: Evaluation of alpha-i and a!-pha-2 adrenoceptor-mediated vaso-constriction in the in situ, autoper-fused, pulmonary circulation of theanesthetized dog, 217

Sherlock, D. J., see Jaffe, B. M., 536Shiverick, K. T., Swanson, C., Saihab, A. S.

and James, M. 0.: Differential induc-tion of ethoxyresorufm-O-deethylasein tissues of the rat placenta, 1108

Shriver, D. A., see Katz, L. B., 587

Shuman, R T., see Cohen, M. L., 769Simpson, P. J., Smith, C. B., Jr., Rosenthal,

G. and Lucchesi, B. R.: Reduction inthe incidence of thrombosis by thethromboxane synthetase inhibitorCGS 13080 in a canine model of cor-onary artery injury, 497

Singer, R. M., see Ryan, M. J., 473SKF 38393, supersensitivity, apomorphine,

rotational behavior (mice), 242Skolnick, P., see Barrett, J. E., 1009Smith, C. B., Jr., see Simpson, P. J., 497Smith, D. M., see Cubells, J. F., 508Smith, E. R., Miller, T. B., Palermo, N. J.

and Donovan, D. W.: Effects on ca-nine prostatic secretion of somedrugs that modify ion transport, 26

Smith, P. G., see Mills, E., 1014Smith, T. W., see Wei, E. T., 783

Snell, L. D. and Johnson, K. M.: Character-ization of the inhibition of excitatoryamino acid-induced neurotransmit-ter release of the rat striatum byphencycidine-like drugs, 938

Snyder, F. R., see Szikszay, M., 192Snyder, S. H., see Largent, B. L., 739Sodium, transport, detergent effects, un-

nary bladder (toads), 415Sodium chloride

cotransport, bumetanide and, renal thicklimbs (mice), 407

transport, sodium-potassium-ATPase(dogs), 327

Sodium-potassium-ATPase, transfer rate,sodium-chloride transfer and (dogs),327

Sodium valproate, chronic ethosuximideand, behavioral toxicity, epilepsy (ba-boons), 32

Solaro, R. J., Bousquet, P. and Johnson, J.D.: Stimulation of cardiac myofila-

ment force, ATPase activity and tro-ponin C Ca� binding by bepridil, 502

Somogyl, G. T., see Vizi, E. S., 701

Sonsalla, P. K., Gibb, J. W. and Hanson, G.R.: Roles of D1 and D2 receptor sub-types in mediating the methamphe-tamine-induced changes in mono-amine systems, 932

Spealman, R. D., see Wettstein, J. G., 522Spector, S., see Johnson, M. D., 855

Spilman, S. D., see Kraemer, F. B., 905Spinal cord

dynorphin A, administered intrathecally

(rats), 833

Met-enkephalin-like release, kelatorphan(rats), 360

Spinelli, W. and Rosen, M. R.: Frequency-dependent actions of phenytoin inadult and young canine Purkinje fi-bers, 794

Spry, L., Lakshmi, V. M., Zenser T. andDavis, B.: Metabolism and excretion

1986 Index 1157

of nitrofurothiazole bladder carcino-gens, 457

Starmer, C. F., see Moorman, J. R., 159Stassen, F., see Mann, W. A., 401Steel, D. J., see Rinehart, R. K., 178Sterols, synthesis, ketoconazole effects, 905Stevens, C. W. and Yaksh, T. L.: Dynorphin

A and related peptides administeredintrathecally in the rat: A search forputative kappa opiate receptor activ-ity, 833

Stokes, G. S., see Marwood, J. F., 267Strauss, H. C., see Moorman, J. R., 159Streptozotocin, diabetes mellitus, bladder

dysfunction in (rats), 773Stress

antidepressant drug injection and, amyg-dala (rats), 758

cortical dopamine metabolism and (rats),693

Striatal kainate lesions, benzodiazepine re-ceptors, regulation of (rats), 739

Stumpf, W. E., see Duncan, G. E., 758Stupecky, G. L., Murray, D. L. and Purdy,

R. E.: Vasoconstrictor threshold syn-

ergism and potentiation in the rabbitisolated thoracic aorta, 802

Submucous plexus, neuropeptide Y, effecton ion transport, ileum (rabbits), 167

Substance K, substance P and, neurokininmotor effect, duodenum (rats), 341

Substance Preceptors, see Receptorssubstance K and

micturition reflex, multiple tachykininreceptors (rats), 259

neurokinin motor effect, duodenum(rats), 341

Substantia nigra, depolarization block in-duction, midbrain dopamine neurons(rats), 1092

Sulfation, pharmacokinetic studies, acet-aminophen disposition, maternal-

placental-fetal unit (sheep), 198Sulpiride, methamphetamine-induced

changes and, monoamine systems(rats), 932

Superior cervical ganglion, DA1 receptor ac-tivation in, dopamine or denoldopam

(rats), 547

Swanson, C., see Shiverick, K. T., 1108

Sybertz, E., see Antonaccio, M. J., 378Sympathectomy, adrenergic and nonadre-

nergic pressor mechanisms (rats),1014

Sympathetic function, cardiac, presynaptic

regulation (guinea pigs), 447

Sympathetic nerves, beta adrenoceptor an-

tagonists, antihypertensive effects(rats), 372

Sympathetic nervous system, vasopressin,

sodium-dependent hypertension and

(rats), 492Szikszay, M., Snyder, F. R. and London, E.

D.: Interactions between verapamiland morphine on physiological pa-rameters in rats, 192

Tachycardia, excess, antihistamines and lo-cal anesthetics (dogs), 367

Takenaga, T., see Yukimura, T., 707Talmaciu, R. K., see Hoffmann, I. S., 437Tenoxicam, acceleration of elimination,

cholestyramine (dogs), 295#{244}-9-Tetrahydrocannabinol, luteinizing hor-

mone and prolactin suppressive ef-fects of, chronic prepubertal treat-ment of female (rats), 1034

Tetrodotoxinjejunal contractility, after chronic abla-

tion, myenteric plexus (rats), 372neuropeptide Y, effect on ion transport,

ileum (rabbits), 167Theophylline, prostatic secretion, drug-

modified ion transport (dogs), 26Thermoregulation, a!pha-i,2 adrenoceptors,

effect of cooling, saphenous and fern-oral veins (dogs), 139

Thiazide diuretics, chloride absorption and,distal colon (rabbits), 912

Thimerosal, acyl-coenzyme A:lysolecithinacyltransferase inhibitors, endothe-hum-derived vascular relaxing factor(rabbits), 352

Thiorphan, kelatorphan, Met-enkephalin-

like release, spinal cord (rats), 360Thomasson, D. L., see Danon, A., 95, 125Thoolen, M. J. M. C., see Chits, A. T., 224Thornburg, J. E., see Atchison, W. D., 618Threshold synergism, potentiation and, vas-

oconstrictor, thoracic aorta (rabbits),802

Thrombin, artery contraction and, alpha ad-renoceptor agonists and (rabbits),947

Thrombolysis, epithelial tissue plasminogenactivator (rabbits), 254

Thrombosis, coronary artery, thromboxanesynthetase inhibitor CGS 13080 ef-fects (dogs), 497

Thromboxane A2, thrombosis and, coronaryartery (dogs), 497

Thromboxane synthetase, thrombosis and,coronary artery (dogs), 497

Thurman, R. G., see Badr, M. Z., 1138Thurman, R. G., see Belinsky, S. A., 1132Thyrotropin-releasing hormone, benzodi-

azepine interactions, binding sites,characterization (rats), 178

Tierney, M. A., see Grover, G. J., 868Timmermans, P. B. M. W. M., see Chiu, A.

T., 224Tine!, M., see Letteron, P., 685Toda, N., Okamura, T. and Miyazaki, M.:

Age-dependent changes in the re-sponse of isolated beagle coronary ar-teries to transmural electrical stimu-lation and catecholamines, 319

Todd, E. L. and Abernethy, D. R.: Phar-macokinetics and dynamics of (±)-

verapamil in lean and obese Zuckerrats, 642

Tohse, N., see Hattori, Y., 670Trachea, smooth muscle, adrenoceptor-me-

diated mechanical response (dogs),679

Transmitter release, neuronal uptake inhib-itor effects, drug interactions (nab-bits), 437

Transmural nerves, stimulation, serotoninand, basilar artery (rabbits), 880

Trichlormethiazide, chloride absorption

and, distal colon (rabbits), 912Trifluoperazine, serotonin contraction and,

uterus and jugular vein (rats), 860Trqjonin, bepridil effects, cardiac myofila-

ments (pigs), 502Tsao, C. C., see Chelly, J. E., 665

Turriui, M., Pitt, B. R., Ryan, J. W., Chung,A. Y. K., Clark, M. B. and Gil!is, C.

N.: Uptake of N-[1(S)-carboxy-(4-

OH-3-125I-phenyl)ethylj-L-Ala-L-Pro, an inhibitor of angiotensin-con-venting enzyme by rabbit lungs insitu, 14

Tyrey, L., see Field, E., 1034

UDP-glucuronic acid, hepatic energy state,conjugation and (rats), 457

UK 14,304a!pha-1,2 adrenoceptors

effect of cooling, saphenous and femo-ral veins (dogs), 139

response coupling, saphenous and fern-oral veins (dogs), 131

Ulm, E. H., see Lin, J. H., 978Umans, V. A., see Rosenbaum, J. S., 396Urethan, central nervous system depres-

sant, long- and short-sleep (mice),1028

Urinary bladderabnormalities of contractility, streptozo-

tocin-induced diabetes (rats), 773

cancer, nitrofurothiazole carcinogen me-tabolism (rats), 457

micturition reflex activation, substance Pand K, multiple tachykinin receptors(rats), 259

sodium transport, detergent effects(toads), 415

transepitheial water flux, vasopressin an-

alog inhibition of (toads), 401Urine, flow, a-hANP and (dogs), 707

Valproic acid, chronic ethosuximide and, be-havioral toxicity, epilepsy (baboons),32

van den Berg, W. B., see Raghoebar, M., 302van Ginneken, C. A. M., see Raghoebar, M.,

302Vanhoutte, P. M., see Flavahan, N. A., 131,

139Vas deferens, CH-38083 effects (rats, mice),

701Vasoconstriction

pulmonary circulation, alpha-1,2 adre-noceptors, evaluation (dogs), 217

sympathetic, renin secretion and, thyro-tropin-releasing hormone (rats), 232

Vasopressin, vascular effects of, chronicblockade, high sodium renal hyper-tension during (rats), 492

Vasopressin agonists, inhibition of trans-epithelial water flux, urinary bladder(toads), 401

Ventral tegmenta! area, neuromedin N ac-tions, 1126

Verapamil

effect of prostaglandin E� synthesis, by-dronephrotic cortical interstitial cells(rabbits), 125

isoproterenol and prostaglandin E�, air-way smooth muscle relaxation (dogs),76

morphine interactions, calcium antago-fists, physiological parameters(rats), 192

pharmacokinetics and dynamics, obesityand (rats), 642

Vermeulen, M., see Lambert, C., 307Vince, R, see Dunham, E. W., 954

Vizi, E. S., Harsing, L. G., Jr., Gas!, J.,Kapocsi, J., Bernath, S. and Somogyi,G. T.: CH-38083, a selective, potent

1158 Index Vol. 238

antagonist of alpha-2 adrenorecep-tors, 701

W6211, pH potentiation, drug pK�, sodiumchannel blockade in ventricular myo-cardium (guinea pigs), 159

Walewski, J. L., see Okamoto, M., 1004

Walker, M. J., see Carroll, M. E., 1Walker, S. T., see Weiss, J., 969Walter, J. B., see Moore, D. H., 76

Wamsley, J. K., see Gulya, K., 720Wang, L. H., Rudolph, A. M. and Benet, L.

Z.: Pharmacokinetic studies of thedisposition of acetaminophen in thesheep maternal-placental-fetal unit,198

Ward, S. J., LoPresti, D. and James, D. W.:

Activity of mu- and delta-selectiveopioid agonists in the guinea pigileum preparation: Differentiationinto peptide and nonpeptide classeswith �-funaltrexamine, 625

Warltier, D. C., see Pelc, L. R., 113Water, transepithelial flux, inhibition by

vasopressin agonists, urinary bladder(rats), 401

Webner, J. M., see Manley, R. J., 1028Wei, E. T., Kiang, J. G., Buchan, P. and

Smith, T. W.: Corticotropin-releas-ing factor inhibits neurogenic plasmaextravasation in the rat paw, 783

Weiss, B., see Winkler, J. D., 242Weiss, H. R., see Grover, G. J., 868

Weiss, J., Walker, S. T., Fallon, M. andGoldfarb, S.: In vivo and in vitro ef-fects ofWR-2721 in experimental by-percalcemia in the rat, 969

Weissman, B. A., see Barrett, J. E., 1009Wettstein, J. G. and Spealman, R. D.: Be-

havioral effects of zopiclone, CL 218,872 and diazepam in squirrel mon-keys: Antagonism by Ro 15-1788 andCGS 8216, 522

Wetzel, G. T., see McDonough, P. M., 612Whiteis, C. A., see Schmid, P. G., 447

Williams, M., see Rinehart, R. K., 178Wilson, P., see Schwertschlag, U., 119Winkler, J. D. and Weiss, B.: Reversal of

supersensitive apomorphine-induced

rotational behavior in mice by con-tinuous exposure to apomorphine,242

Witkin, J. M., see Barrett, J. E., 1009Wittenauer, L., see Cohen, M. L., 860Wong, B. K., see Corcoran, G. B., 54Wood, P. L., see Iyengar, S., 429Wood, P. L., see Rinehart, R. K., 178

Woodwortb, J. R., Mayersohn, M. andOwens, S. M.: Disposition kinetics ofthe monohydroxy metabolites ofphencyclidine in the dog, 900

Woronick, C. L., see Maderazo, E. G., 453

Worth, T. S., see Dunwiddie, C. W., 564WR-2721, experimental hypercalcemia

(rats), 969

Yaksh, T. L., see Stevens, C. W., 833

Yamamoto, K., see Yukimura, T., 707

Yamamura, H. I., see Gulya, K., 720Yamamura, H. I., see Hynes, M. R., 100Yasumoto, T., see Kobayashi, M., 1077

YC-170, vascular and cardiac effects, corn-panison with Bay K 8644 (rabbits,guinea pig), 670

Yee, R, see Moorman, J. R., 159Yohimbine

aipha-2 adrenoceptors, question of exist-ence, tail arteries (rats), 267

sympathetic transmission, beta adre-noceptors, heart (dogs), 334

Yorikane, R., Kanda, A., Kimura, T. andSatob, S.: Effects ofepinephnine, iso-proterenol and IPS-339 on sympa-thetic transmission to the dog heart:Evidence against the facilitatory roleof presynaptic beta adrenoceptors,

334Young, A. B., see Ciliax, B. J., 749Yukimura, T., Ito, K., Takenaga, T., Ya-

mamoto, K., Kangawa, K. and Mat-suo, H.: Possible tubular site of ac-tion in anesthetized dogs of a syn-thetic a-human atrial natriureticpolypeptide, 707

Zenser, T. V., see Danon, A., 95, 125, 457Zera, P., see Rosenbaum, J. S., 396

Zopiclone, behavioral effects (monkeys),

522Zuzack, J. S., see Li, J. H.-Y., 415

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