INFECTION AND IMMUNITYVOLUME 61 * OCTOBER 1993 * NUMBER 10

Vincent A. Fischetti, Editor in Chief(1994)

Rockefeller UniversityNew York, N.Y.

Barry I. Eisenstein, Editor (1994)Lilly Research LaboratoriesIndianapolis, Ind.

Stanley Falkow, Minireview Editor (1995)Stanford University School ofMedicineStanford, Calif.

Dexter H. Howard, Editor (1996)University of CaliforniaLos Angeles, Calif.John M. Mansfield, Editor (1998)University of WsconsinMadison, WIS.Jerry R McGhee, Editor (1994)University ofAlabamaBinningham, Ala.David C. Morrison, Editor (1997)University ofKansas Medical CenterKansas City, Kans.

Carol A. Nacy, Editor (1995)EntreMed Inc.Rockville, Md.

Alison O'Brien, Editor (1996)Uniformed Services University of theHealth Sciences

Bethesda, Md.

Philippe J. Sansonetti, Editor (1997)Institut PasteurParis, France

Soman N. Abraham (1994)Julia W. Albright (1995)Glen Armstrong (1995)Sandra K. Armstrong (1993)Joseph T. Barbleri (1995)Alan G. Barbour (1995)Scott Barnum (1995)Joel B. Baseman (1994)Robert E. Baughn (1993)Patrick Bavoil (1993)Blaine L. Beaman (1994)Jorge L. Benach (1995)D. Kay Blanchard (1995)Martin J. Blaser (1995)Arnold S. Bleiweis (1993)W. Chaunce Bogard (1995)Gregory A. Bohach (1993)Patrick Brennan (1994)David E. Briles (1994)Robert R. Brubaker (1993)DrusllHa L. Burns (1994)Gerald Byrne (1994)Richard A. Calderone (1993)Stephen Calderwood (1994)Harlan Caldwell (1993)Priscilla A. Campbell (1993)Janne G. Cannon (1993)Gail H. Cassell (1993)John Chan (1994)Bruce Chassy (1993)Ambrose Cheung (1993)Nicholas P. Cianciotto (1993)Witold Cieplak (1994)John 0. Cisar (1994)Josephine Clark-Curtiss (1993)P. Patrick Cleary (1993)Steven Clegg (1993)John D. Clements (1995)Don B. Clewell (1993)Myron S. Cohen (1993)Paul S. Cohen (1993)R. John Collier (1994)Frank M. Collins (1995)Guy Cornelis (1993)Rebecca Cox (1993)Jorge H. Crosa (1994)Jim E. Cutler (1993)

Barbara H. Iglewski, Chairman,

EDITORIAL BOARDCharles J. Czuprynski (1995)George S. Deepe, Jr. (1995)Judith E. Domer (1995)Gordon Dougan (1994)Lawrence A. Dreyfis (1993)Roman Dziarski (1993)Robert A. Eisenberg (1993)Toby K. Elsenstein (1993)John H. Eldridge (1995)Charles 0. Elson (1995)N. Cary Engleberg (1995)Joseph C. Fantone m (1993)Joseph J. Ferretti (1995)Dara W. Frank (1993)Rolf G. Freter (1993)Ronald J. Gibbons (1994)Janet R. Gilsdorf (1993)Mae Go (1993)William E. Goldman (1995)Emil Gotschllch (1994)Patrida Guerry-Kopecko (1993)Paul Gulig (1993)Thomas L. Hale (1993)Jane L. Halpern (1993)Shigeyuki Hamada (1993)Eric J. Hansen (1995)David L. Hasty (1994)Richard Hector (1995)Fred Heffron (1993)Erik Hewlett (1993)James B. Hicks (1994)Susan Hollingshead (1995)Jan Holmgren (1994)Anne Morris Hooke (1995)Ralph R. Isberg (1993)Graham Jackson (1995)Matt Jackson (1995)William R. Jacobs, Jr. (1993)James B. Kaper (1994)Stefan H. E. Kaufmann (1995)Paul M. Kaye (1994)Mogens Kilian (1993)Theo N. Kirkland (1995)Hiroshi Kiyono (1995)Dennis J. Kopecko (1995)Malak Kotb (1994)Thomas R. Kozel (1994)

Publications Board

Arnold Kreger (1995)Howard K. Kuramitsu (1994)David Lelby (1995)Myron Levine (1994)Stephen Lory (1993)Carl F. Mam (1993)Anthony Maurelli (1993)Roderick McCallum (1994)Bruce McClane (1995)John Mekalanos (1995)Eleanor S. Metcalf (1995)Suzanne M. Michalek (1995)Michael L. Misfeldt (1994)Harry Mobley (1995)Robert L. Modlin (1995)Robert N. Moore (1995)Steve L. Moseley (1993)Richard Moxon (1993)Antony J. Mukkada (1993)Martha H. Mulks (1995)Robert S. Munford (1992)Robert S. Munson (1995)Juneann W. Murphy (1993)Thalia I. Nicas (1995)Michael V. Norgard (1995)Robert North (1995)Dennis E. Ohman (1995)Andrew B. Onderdonk (1993)Paul Orndorff (1993)Michael J. Parmely (1995)Jeffrey Parsonnet (1995)Shelley M. Payne (1994)Kenneth Peterson (1993)William A. Petri, Jr. (1993)Gerald B. Pier (1995)Daniel A. Portnoy (1995)Richard A. Proctor (1993)Justin D. Radolf (1993)Reuben Ramphal (1994)Jonathan I. Ravdin (1995)Richard F. Rest (1993)Judith C. Rhodes (1995)Donald Robertson (1993)Sara W. Rothman (1993)Craig E. Rubens (1994)Michael W. Russell (1994)Roy R. B. Russell (1995)

Linda M. Illig, Director, Journals

Catharine Saelinger (1993)James Samuel (1995)Stewart Scherer (1994)Patrick SchlHevert (1993)June R. Scott (1993)Penelope G. Shackelford (1995)Alan Sher (1995)Thomas M. Shinnick (1994)Richard P. Silver (1995)Richard Silverstein (1995)Jerry Simecka (1994)Emil Skamene (1994)Jack D. Sobel (1993)P. Frederick Sparl (1993)Walter E. Stamm (1993)George Stewart (1993)Susan C. Straley (1995)Barnet M. Sultzer (1994)Catharina Svanborg (1993)John L. Swanson (1993)Yosifimi Takeda (1994)Martin A. Taubman (1993)Diane W. Taylor (1993)John Thompson (1993)Michael R. Thompson (1993)Trevor J. Trust (1994)Elaine Tuomanen (1993)Rodney K. Tweten (1993)Ivo van de Ron (1993)Thomas E. Van Dyke (1995)Jan D. A. van Embden (1994)Michael L. Vasil (1993)Peter A. Ward (1994)Alison Weiss (1995)Rodney Welch (1993)Tracy D. Wilkins (1993)Dwight Williams (1993)Peter H. Williams (1993)Mark E. Wilson (1994)Herbert H. Winkler (1995)Marcia K. Wolf (1993)Patricia L. Worsham (1993)Priscilla B. Wyrick (1993)Douglas B. Young (1994)Lowell Young (1994)H. Kirk Zeigler (1995)

Jack Kenney, Production Editor

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Author IndexAbrams, John S., 4038Adams, L. B., 4173Ally, B., 4085Alonso-Vega, Cristina, 4280Amano, Ken-Ichi, 4350Ansher, Sherry, 4240Aragon, Adam S., 4232Astagneau, P., 4498Athamna, Abed, 4208Ausiello, Clara M., 4105Azen, Edwin, 4434

Baca, Oswald G., 4232, 4485Barthold, Stephen W., 4493Bates, Janice, 4382Beaman, Miles H., 4038Beck, Deborah S., 4493Bermudez, Luiz E., 4126Bernabeu, Carmelo, 4225Bertram, G., 4263Bille, J., 4099Bohach, Gregory A., 4254Borg-von-Zepelin, Margaret,4398

Borland, Robert, 4473Brade, Helmut, 4514Brade, Lore, 4514Bridgewater, Jennifer, 4240Brown, A. J. P., 4263Brunton, J., 4085Buhler, John E., 4232Butcher, Wade G., 4119

Caldwell, Harlan D., 4406Callister, S. M., 4367Cassone, Antonio, 4105Castro, Mario, 4302Caufield, Page C., 4119Chang, A., 4293Cheng, Shuk Han, 4501Cheong, Yuet-Meng, 4527Chougnet, C., 4498Christner, Robert F., 4232Clark, Burton D., 4356Clark, C. G., 4085Clyne, Marguerite, 4051Coffey, Tracey J., 4382Collaco, Christopher R., 4427Covaro, Gail, 4126Crabb, Joseph, 4079Creasey, A. A., 4293Crusiaux, Alain, 4280Cuevas, William A., 4310

Dallas, Mary Miller, 4415Daniels, Maggie, 4382da Silveira, Jos6 Franco, 4196Datta, Manjula, 4501Davis, William C., 4254de Azavedo, J. C. S., 4085de Boer, J. P., 4293de Graaf, F. K., 4518De Graaf, L., 4167De Grandis, Stephanie, 4510De Groote, Dona, 4280Deighton, Margaret, 4473Deloron, P., 4498de Souza, Mark S., 4493Devi, Shamala, 4527Dickens, Sarah M., 4360Dinarello, Charles A., 4356Doyle, Patricia S., 4079Drumm, Brendan, 4051

Duane, Peter G., 4392Dubois, B., 4498Duchow, Jochen, 4280Dyer, Roy B., 4427Dytoc, M., 4085

Ebrahim, Jalal Seyed, 4523Eerenberg, A. J. M., 4293Eiffert, Helmut, 4523Elson, Charles O., 4272Erroi, Annalaura, 4356

Fandeur, Thierry, 4469Fantuzzi, Giamila, 4356Fasano, Alessio, 4462Fertel, Richard, 4333Fidel, Paul L., Jr., 4202Finlay, B. Brett, 4489Fisher, Susan J., 4434Fleer, A., 4167Fleischer, Bernhard, 4507Foster, John W., 4489Franco, Fuilvia R. S., 4196Frankel, Gad, 4208Friedman, Herman, 4027Fujihashi, Kohtaro, 4272Fujita, Mild, 4350Fukutomi, Y., 4173

Galen, James E., 4462Garcia-del Portillo, Francisco,

4489Gessani, Sandra, 4105Ghezzi, Pietro, 4356Gilks, Charles, 4382Giovarelli, Mirella, 4356Glew, Robert H., 4232Gnocchi, Paola, 4356Godoy, Veronica G., 4415Goldman, Michel, 4280Golenbock, Douglas T., 4452Gomez, Maria J., 4105Gooday, G. W., 4263Goudeau, Alain, 4112Gow, N. A. R., 4263Grau, Georges E., 4182Greenspan, D., 4263Greenspan, J. S., 4263Gueirard, Pascale, 4072Guiso, Nicole, 4064, 4072Gupta, Radhey S., 4225Gyles, Carlton L., 4510

Hack, C. E., 4293Hacker, Jorg, 4480Hall, Andrew C., 4326Hall, Robert H., 4326Handelsman, M. Y. C., 4085Hansen, George M., Jr., 4493Haritani, Makoto, 4153Hasty, David L., 4208Hechemy, Karim E., 4485Hermann, Elisabeth, 4507Herzog, Norbert K., 4427Hill, Priscilla J., 4045Hoffman, Orleen A., 4302Hofmann, Heidelore, 4158Hohenstein, Peter, 4217Hollander, H., 4263Holst, Otto, 4514Hunter, Christopher A., 4038Huntley, James S., 4326Husson, C6cile, 4280

Isetta, Anna, 4356

Jackson, L. A., 4338Jackson, Raymond J., 4272Janoff, Edward N., 4392Jasni, Sabri, 4286Jaton-Ogay, K., 4099Jeurissen, Suzan H. M., 4504Jones, Amanda L., 4045Jordens, J. Zoe, 4382Jouault, Thierry, 4398

Kabha, Kisra, 4208Kaper, James B., 4462Kell, Christopher M., 4382Khelef, Nadia, 4064Kim, Lucy J., 4493Kiyono, Hiroshi, 4272Klein, Michel H., 4406Klein, Thomas W., 4027Kobayashi, Yoshinao, 4058Koga, Toshihiko, 4344Konishi, Hisanori, 4147Korhonen, Timo K., 4480Kozel, Thomas R., 4360Krahenbuhl, J. L., 4173Kramer, Michael D., 4158Kruszewska, Danuta, 4188Kubo, Shigemasa, 4375Kubota, Hiroshi, 4375

Lachumanan, Ramkumar,4527

Lantz, Marilyn S., 4119Latge, J. P., 4099Lawson, Gordon H. K., 4286Lepage, Gilbert, 4398Lepers, J. P., 4498Le Scanf, C6cile, 4469Lim, L. C. L., 4367Limper, Andrew H., 4302Liu, Yannan, 4452Lopez-Bote, Juan Pedro, 4225Lopez-Guerrero, Jos6

Antonio, 4225Louie, M., 4085Lovrich, S. D., 4367Lowrie, Douglas B., 4501Lupher, Mark, 4254Lynch, Maria E., 4202Lynn, William A., 4452Lyon, Julie D., 4254

MacIntyre, Neil, 4286Mackenzie, Donald, 4398Mackie, Rebecca A., 4286Mai, G. T., 4338Makela, P. Helena, 4248Malamy, Michael H., 4415Manning, Donald S., 4093,4406

Mantle, Michele, 4131Marchant, Arnaud, 4280Marko, Michael, 4485Marr, James C., 4254Martinez-Martinez, L., 4167Matsushiro, Aizo, 4375Matsuya, Tokuzo, 4375Mattsson, E., 4167McBride, Barry C., 4139McCormack, J. G., 4338McGhee, Jerry R., 4272McKee, Mary, 4485

McOrist, Steven, 4286Mengozzi, Manuela, 4356Meyer zum Buschenfelde,Karl-Hermann, 4507

Michalski, Jane, 4462Mitchison, Denis A., 4501Monod, M., 4099Morita, Takashi, 4375Morshed, Muhammad G.,4147

Morton, Daniel J., 4033Moter, Sabine E., 4158Muotiala, Anna, 4248Murakami, Kazuhisa, 4058Murdin, Andrew D., 4406Musser, James M., 4033, 4112

Naciri, Muriel, 4440Nakai, Motoyuki, 4344Nakazawa, Teruko, 4147Neef, Natasha, 4286Neese, Lewis W., 4302Neve, Pierre, 4280Newton, Catherine A., 4027Niesel, David W., 4427

Ofek, Itzhak, 4208Ohman, Dennis E., 4208Ohnishi, Yuichi, 4375Ohta, Hirotaka, 4344Okahashi, Nobuo, 4344Okazaki, Ken-Ichi, 4058Orencole, Scott F., 4356Ortiz, Maria Antonia, 4225

Paez, Eduardo, 4225Pang, Tikki, 4527Paranhos-Bacalla, Glaucia S.,

4196Paris, S., 4099Park, Jaechan, 4333Park, Yoonsuk, 4139Parkkinen, Jaakko, 4480Parnell, Michael J., 4406Paul, John, 4382Peeters, Carla, 4217Peeters, Johan E., 4440Perfect, John R., 4446Petersen, Carolyn, 4079Pfrommer, Gail S. T., 4360Pier, G. B., 4338Piguet, Pierre F., 4182Poolman, Jan T., 4217Poulain, Daniel, 4398Prabhakar, R., 4501Prakobphol, Akraporn, 4434Probst, Peter, 4507

Quentin, Roland, 4112

Remington, Jack S., 4038,4126

Rikihisa, Yasuko, 4333Roberson, Jerry R., 4254Rodda, Stuart J., 4527Roem, D., 4293Roman, Miriam J., 4232, 4485Rombough, Charlane, 4131Rosenau, Agnes, 4112Rubins, Jeffrey B., 4392Rude, Thomas H., 4446Russo, Thomas A., 4415Ryser, Jean Etienne, 4182

i

ii AUTHOR INDEX INFECT. IMMUN.

Samsonoff, William A., 4485Sanglard, D., 4099Sathyamoorthy, Venugopal,

4326Schaible, Ulrich E., 4158Schell, R. F., 4367Schlott, Thilo, 4523Scriba, Marianne, 4523Senaldi, Giorgio, 4182Seow, W. K., 4338Sherman, P., 4085Simon, Markus M., 4158Sironi, Marina, 4356Sizaret, Pierre Yves, 4112Smith, Abigail L., 4493Snoy, Phil, 4240Sobel, Jack D., 4202Songer, J. Glenn, 4310Spagnoli, Giulio C., 4105Spratt, Brian G., 4382

Standing, Joseph E., 4302Stewart, Scott J., 4093Stull, Terrence L., 4033Su, Hua, 4406Suto, Tsunehisa, 4350Swamy, Raji, 4501Switalski, Lech M., 4119Swoboda, R. K., 4263

Tacchini-Cottier, Fabienne,4182

Tagawa, Yuichi, 4153Taylor, F. B., Jr., 4293Thompson, Walter, 4240Thong, Y. H., 4338Timmerman, C. P., 4167Toffaletti, Dena L., 4446Trinel, Pierre-Andre, 4398Turco, Jenifer, 4317

Tylewska-Wierzbanowska,Stanislawa K., 4188

Urbani, Francesca, 4105

van der Biezen, Jenny, 4217van der Ley, Peter, 4217van Heeckeren, Anna M.,

4333Vanopdenbosch, Emmanuel,

4440Van Strijp, J. A. G., 4167Vazeux, Gilles, 4469Verbrugh, H. A., 4167Verhoef, J., 4167Vermeulen, Arno N., 4504Vervelde, Lonneke, 4504Vesin, Christian, 4182Villacorta, Isabel, 4440Virkola, Ritva, 4480

Walker, K. Barry, 4501Wallich, Reinhard, 4158Weisel, Heather R., 4392Widen, Raymond H., 4027Willemsen, P. T. J., 4518Wilson, Michael A., 4360Winkler, Herbert H., 4317Woods, Donald E., 4045Wozniak, Daniel J., 4208

Xu-Amano, Jiangchun, 4272

Yamauchi, Lucy M., 4196Yee, Arlene J., 4510Yokota, Masataka, 4147Yoshida, Nobuko, 4196Young, Bryan J., 4360Yuasa, Noboru, 4153

Zychlinsky, Arturo, 4064

Call for Papers...

CLINICAL AND DIAGNOSTIC LABORtATORY IMMUNOLOTBY

The American Society for Microbiology will commence publication of a bimonthly journal, Clinical andDiagnostic Laboratory Immunology, in January 1994 that will bring together information on the latestdevelopments in human immune response assessment, including indications for testing, methods, andinterpretation of results.

Peer-reviewed research articles describing the laboratory diagnostic aspects of the following will be featurpd-¶* humoral and cellular immunity, including specific immune cell functions (B cells, T cells, and their subsets* mediators and cytokines, complement components, and other serum proteins* natural killer cells, monocytes/macrophages, nautrophils, and myeloid cells* immune responses to infection caused by bacteria, viruses, fungi, and parasites* AIDS and other retroviral diseases* primary and secondary immunodeficiency disordersevaluation of hypersensitivity and autoimmune diseases

* histocompatibility and transplantation immunology* lymphoreticular malignancies and cancer immunology* immunogenetic testing applied to human disease diagnosis and evaluationimmunologic monitoring, including flow cytometry and vaccine ther4pylaboratory immunology as related to allergy, dermatology, immunohemafology,Ahev.oral medicine, and other medical and surgical subspeciafties .''

Novel animal models relevant to the diagnosis of human diss: weimmune response, new or evolving technology in diagnostic mOtbds1responses and/or values, case reports, quality control, and biosastcs suitablebtpjournal.

Minireviews, guest commentaries, and letters to the wil be Incuded

Editor In Chief: Steven D. Douglas. Editors: James Fols, David ENOma9psel, 4 'aseDaniel P. Stites, and Theresa L. Whiteside.

Editorial Board: P. W. Askenase, J.-F. Bach, Z. H. Berwtwioh §i. F. Bo AA. urei,D. E. Campbell, C. B. Carpenter, W. S. Ceglowski, 1.JChecL , L.C kc,t rCrmi

Rundles, B. Detrick, J. Y. Djeu, P. Dore-Duffy, A.-Etzionif3. I, Fahe T.k ItP J. felsburg, -T. A. Fleisher, M. M. Frank, H. Friedman, P. C. Gas, B. C GilRI", J. A Q*et, Riht4 L. 0gOpyQR. J. Harbeck, R. B. Herberman, R. L. Hodinka, T.N,of,nt, Pu $rbis*, Je Q. Je,¶IN. R. Kamani, D. F. Keren, T. Kishimoto, P. Lalezar, A.L dy, S:A L,;-MM. S. Leffell, J. A. Levy, S. A. Lobel, L F. Macyer, :J. B. ,t umur& ,L. M. Pachman, J. E. W. Palmblad, G. M. Penn, R. Pay,J. B, Kf rs A,Pk#ffp1C. D. Platsoucas, S. A. Plotkin, H. E. Prince, B. S.Rabin,,E. ReAs.,R. F. Schell, R. T. Schooley, P. H. Schur, S. A. Schwartz, N.W *aj. LEilr,E. R. Stiehm, J. Verhoef, G. Virella, G. N. Vyas, M. E. We A. Pae nrD. Zucker-Franklin, S. H. Zuckerman, and B. Zweimarn. . :-Pazner,

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