information in biology. outline what is synthetic biology? biological clocks the “repressilator”...
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Information in Biology
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Outline
What is synthetic biology?
Biological ClocksThe “Repressilator”
Signal transductionThe “Diverter”
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Outline
What is synthetic biology?
Biological ClocksThe “Repressilator”
Signal transductionThe “Diverter”
![Page 4: Information in Biology. Outline What is synthetic biology? Biological Clocks The “Repressilator” Signal transduction The “Diverter”](https://reader036.vdocuments.net/reader036/viewer/2022070400/56649f115503460f94c2487c/html5/thumbnails/4.jpg)
Outline
What is synthetic biology?
Biological ClocksThe “Repressilator”
Signal transductionThe “Diverter”
![Page 5: Information in Biology. Outline What is synthetic biology? Biological Clocks The “Repressilator” Signal transduction The “Diverter”](https://reader036.vdocuments.net/reader036/viewer/2022070400/56649f115503460f94c2487c/html5/thumbnails/5.jpg)
What is synthetic biology?
The design and construction of new biological parts, devices, and systems
The “Repressilator”
The re-design of existing, natural biological systems for useful purposes.
The “Diverter”
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Outline
What is synthetic biology?
Biological ClocksThe “Repressilator”
Signal transductionThe “Diverter”
![Page 9: Information in Biology. Outline What is synthetic biology? Biological Clocks The “Repressilator” Signal transduction The “Diverter”](https://reader036.vdocuments.net/reader036/viewer/2022070400/56649f115503460f94c2487c/html5/thumbnails/9.jpg)
Biological - Clocks Three questions
1. How does it work
2. How does it synchronize
3. How does it translate to activity
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Biological - Clocks
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Biological - Clocks
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Biological - Clocks
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Outline
What is synthetic biology?
Biological ClocksThe “Repressilator”
Signal transductionThe “Diverter”
![Page 14: Information in Biology. Outline What is synthetic biology? Biological Clocks The “Repressilator” Signal transduction The “Diverter”](https://reader036.vdocuments.net/reader036/viewer/2022070400/56649f115503460f94c2487c/html5/thumbnails/14.jpg)
The “Repressilator”
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Repressilator
oscillations are favored by Strong promotersEfficient ribosome-binding sitesTight transcriptional repression Comparable protein and mRNA decay rates
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Repressilator
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Repressilator
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Outline
What is synthetic biology?
Biological ClocksThe “Repressilator”
Signal transductionThe “Diverter”
![Page 19: Information in Biology. Outline What is synthetic biology? Biological Clocks The “Repressilator” Signal transduction The “Diverter”](https://reader036.vdocuments.net/reader036/viewer/2022070400/56649f115503460f94c2487c/html5/thumbnails/19.jpg)
Signal Transduction
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The Yeast system
Scaffold proteins
Mediating recruitment Improve efficiency of signal
transfer. Facilitate interactions among
different signal pathways Control localization of signal
proteins within a cell.
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Outline
What is synthetic biology?
Biological ClocksThe “Repressilator”
Signal transductionThe “Diverter”
![Page 22: Information in Biology. Outline What is synthetic biology? Biological Clocks The “Repressilator” Signal transduction The “Diverter”](https://reader036.vdocuments.net/reader036/viewer/2022070400/56649f115503460f94c2487c/html5/thumbnails/22.jpg)
The Pre-Diverter
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The Diverter
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Diverter results
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Diverter results
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Summary What is synthetic biology? The design and construction of new biological parts,
devices, and systems
The Repressilator
The re-design of existing, natural biological systems for useful purposes.
The Diverter
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Signal transduction
movies
signal transduction http://www.youtube.com/watch?v=tMMr
TRnFdI4
signal transduction http://www.rpi.edu/dept/bcbp/
molbiochem/MBWeb/mb1/part2/signals.htm#animat2