innate imm trapping
TRANSCRIPT
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INNATE IMMUNITY: NEUTROPHILS AND THEIR PRODUCTS
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Greek Greek MyelosMyelos = bone marrow = bone marrow
Bursa
Bone marrow
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Act rapidily
Incapable of sustained effort
Act more slowly
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NEUTROPHIL
8 x 106/min
Life span: 2-4 days
Cannot divide
Fine granular cytoplasm
Segmented nucleus
Two pools: circulatingand sequestered inmicrovasculature
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Direct movement of cells (leucocytes) under the influence of an external chemical gradient.
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CHEMOTAXIS
1
2
3
4
5
6
Bacteriaproducts
Integrins/selectins
(gradient)
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Rolling Adherence Emigration
Selectin-mediated
Integrin-mediated
Inflammatorystimuli
Chemotaxis
Blood flow
The stages of neutrophil adhesion and emigration from blood vessels.
PMN
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The proteins and their ligands engaged in neutrophil-vascular endothelial cell binding
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Phagocytosis
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-
+
C
+++
ADHERENCE AND OPSONIZATION
Opsonin (Greek > sauce). A molecule that facilitates phagocytosisby coating foreign particles (neutralizes –ve charges)
Zeta potential
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Receptor for CReceptor for C
Receptor for AbReceptor for Ab
ADHERENCE AND OPSONIZATION
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Streptococcus agalactie
NeutrophilNeutrophil
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ADHERENCE AND OPSONIZATION
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INGESTION AND PHAGOSOME FORMATION
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PHAGOLYSOSOME
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Neutrophil Activation
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DESTRUCTIONThe Respiratory Burst
O2
1
3
4
5
Superoxide anion
Hydrogen peroxide
2
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LYTIC ENZYMES
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SURFACE RECEPTORS
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The Removal of Apoptotic Neutrophils