innovative, compact, and fully mri- compatible advanced pet … · 2020. 5. 14. · reconstruction...
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Innovative, compact, and fully MRI-
compatible advanced PET system
Simple and Simultaneous PET/MRI Solution
An advanced silicon photomultiplier (SiPM) basedPET insert for truly simultaneous PET/MR imagingwith a compact design and low power consumption,and excellent PET detector stability
Simultaneous PET/MR imagingwith dual-modal imaging probes
Mouse lymph node imaging with Brucker BioSpec 70/20 USR 7T MRI
(T2-weighted MRI and 64Cu-NOTA-ironoxide-mannose PET)
Ko GB et al., J Nucl Med, 2016
Preinjection 2 h. postinjection
The world’s first complete and most cost-effective permanent magnet simultaneous PET/MRI solution for preclinical research
High image quality
Exceptional PET and MRI performance
Simultaneous or standalone operation
MRI-based attenuation correction
Compact and Safe – no stray field
Complete system installed in one day
Low maintenance – no cryogens
Lowest power consumption in the industry
with
Integrated animal handling system
with RF coil SimPET insert
Cryogen-free high-performance
MR scanner
MRI specifications Value
Dimension (H x W x D) 132 x 79 x 95 cm
Weight 1550 kg
Magnet opening 97 mm
Imaging volume 120 x 120 x 70 mm
B0 1 T
with The smallest footprint for PET/MRI
2.4 mm
1.35 mm
0.75 mm
1.0 mm1.7 mm
Myocardial [18F]FDG PET in a mouse
[18F]NaF Bone PET in a mouse
18F filled hot-rod phantom
2.0 mm
Oncologic PET/MRI with SUV (standard uptake value) quantification[18F]FDG PET and T2 FSE MRI scans conducted to investigate the effects of tumor-associated macrophages on tumor hypoxia and aerobic glycolysis (Cancer Research, 2019)
High spatial-resolution PET/MR imaging in the mouse arthritis modelSimultaneously acquired and perfectly matched [18F]FDG PET (300 µCi, 60-min uptake) and 3D GRE MR (TR = 25 ms, TE = 3 ms) images in K/BxN arthritis model mouse
T2-weighted FSETR/TE: 3070/66.7 ms
10.5 min scan (15 slices)
Standard uptake value (SUV)
Before treatment
After treatment
[18F]FDG 200 µCi60 min uptake, 30 min scan
[18F]FDG PET
Normal control
PET/MRI GRE MRI
K/BxN model
Multi-modal PET/MRI probes with different core sizesSimultaneous PET/MRI enables the highly accurate assessment of spatiotemporal distribution of radio-labeled IONPs with different core sizes (Courtesy of Prof. YS Lee in Seoul National Univ.).
Synergetic combination of high sensitivity PET and fine resolution MRI High sensitivity of SimPET and fine spatial-resolution of Aspect M7 MRI enable investigations into enhanced tumor targeting with newly developed IONP-based dual modal imaging probe.
Pre injection
MR
I
2 nm 3 nm 5 nm 2 nm 3 nm 5 nm
2 nm 3 nm 5 nm
PE
T/M
RI
64Cu-labeled Encapsulated Iron Oxide Nanoparticles
(IONP)
Post injection (1 hour)
64Cu-IONPs-folate (150 µCi) PET/MRI in a KB tumor model mouse
1h 4h 24h8h 48hPre injection
Simple Workfl ows and Intuitive Graphic User Interface
Real-time count rate monitoring
Real-time FastTomo reconstruction
Flexible list-mode data acquisition
Easy quality control and calibration
PET/MR geometric calibration
Count rate/activity cross-calibration
In-line image reconstruction
Post reconstruction with MRI-based AC
Bq/ml or SUV quantification
SimPET Series for Various MR Machines
Dimension
Specifications
Parameter SimPET-S SimPET-X SimPET-L SimPET-XL
Crystal material LSO
Crystal dimension (mm3) 1.2×1.2×10
Insert inner diameter (mm) 60 76
Insert outer diameter (mm) 99 112
Axial FOV (mm) 55 110 55 110
* Product Specifications are subject to change without notice.
SK V1 Tower 1705,25, Yeonmujang 5ga-gil, Seongdong-gu,Seoul, Republic of KoreaTel: +82-2-766-8745Fax: +82-2-766-8746Web: www.brtnx.com
Sales & Product [email protected] Technical support [email protected]
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