Innovative Solutions Portfolio for Your Dosage Form Needs

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capsugel.com

lipid-based formulations Our team of highly-knowledgeable scientists offers specialized expertise in lipid-based formulations to both speed formulation and improve drug absorption. Supported by our proprietary Lipidex system with over 12 years of laboratory data, Capsugel can quickly define the most suitable microemulsion region for a given compound.

product differentiation & line extensionsExtend your reach and build your brand by leveraging Capsugel’s consumer preferred dosage forms and marketing insights. We can help you select fill options (liquids, pellets or powder), colors, branding and printing to help your product win in the marketplace.

pre-clinical & clinical support From formulation and analytics to small-scale manufacturing for animal and stability studies, Capsugel is a trusted partner to help you prepare for your pre-clinical and clinical trials.

health & nutrition products Capsugel offers a full range of turnkey services for fast-to-market delivery of innovative, quality supplements.

powder formulations Capsugel’s expertise extends to powder formulations giving you the ability to leverage our Powder Formulations Expert System. A proprietary database of information such as drug properties, compatibility with excipients, capsule sizes and company practices can help recommend a winning formula and corresponding tests to be performed.

manufacturing & technical services Capsugel’s staff of Technical Service Engineers provide customers with hands-on manufacturing support including troubleshooting, training and consultation, helping you maximize productivity and minimize waste.

quality management expertiseFrom raw material selection to rigorous manufacturing quality assurance and quality control, Capsugel leads the industry with our quality standards, sharing our expertise to help you maintain excellence in your capsule filling operations.

regulatory assistance Capsugel has country-by-country regulatory and compliance expertise to help you comply with the latest regulations and do business successfully around the globe.

Services that Work for You

With over 100 years of experience in capsule technology, Capsugel can work with you from early stage

development through final production. Our goal is to develop long-lasting relationships with our customers

based on trust, reliability and security.

Get the peace of mind you deserve knowing every Capsugel order is backed by our vast worldwide production network that follows global quality standards aligned with international regulations. ISO certified and cGMP compliant, our certified global quality assurance system ensures consistent batch-to-batch performance for all of our capsule products around the globe.

Capsugel Quality Guarantee

Capsugel’s diverse portfolio of dosage-delivery products, equipment,

and technical services remain at the forefront of healthcare industry

quality and innovation. Our understanding of the global healthcare

market can help you deliver value for all types of active ingredients

and throughout the full product lifecycle.

Capsugel – Leading the World in Innovative Dosage Form Solutions

Formulation Flexibility• The most versatile container for both

liquids and powders

• Requires fewer processing steps and excipients

• Choose from a large array of polymer options to meet your active delivery needs

• Helps improve the stability of sensitive drug compounds and addresses the issue of poorly-water-soluble compounds

• Potential for immediate, modified, sustained or dual release

Dosing Flexibility• Combine active ingredients in a

single capsule for patient and consumer convenience

• Develop innovative product concepts without compromising on production

• Capsules are better suited for cytotoxic and high-potency drugs than tablets

• Cannot be split for more consistent dosing, enhancing patient compliance and preventing possible revenue loss

Marketing Flexibility• Convenient to use and preferred by patients

and consumers, capsules mask ingredient tastes and odors, and are easy to swallow

• Available in a myriad of colors, capsules have an attractive appearance and can be printed with text and graphics

• Market research confirms that consumers consider liquid dosage forms to be “faster acting” and more “effective”

• Prolong patent protection or extend your product line through innovative reformulation concepts supported by our Product Development Centers

Manufacturing Flexibility• Capsules are cost-effective for emerging

markets, product innovations and alternative applications

• Use the same blend and filling process for different capsule sizes

• Leverage Capsugel’s industry leading know-how in powder and liquid filling to optimize your production lines

• Capsugel offers the widest range of sizes, colors and polymers available with the shortest lead-times in the industry to speed your operations

Flexibility = Faster Time to Market

The flexibility of capsules often translates into faster time to market, giving manufacturers a significant competitive advantage.

Quality Products that Deliver Results

Capsules for Powder-fills

coni-snap® hard gelatin capsulesGlobal standard for healthcare products

• The best selling capsule in the world

• Proven performance from small to large production scale

• Pharmaceutical-grade gelatin meeting Pharmacopeia standards

• Preservative-free, starch-free and gluten-free

• Fully customizable

vcaps® and vcaps® plus capsulesHigh performance HPMC (hypromellose) capsules

• Can solve formulation challenges with widespread acceptance for pharmaceutical and nutritional product registrations

• Excellent with low moisture or hygroscopic ingredients

• Vcaps Plus capsules offer fast release performance

• Satisfies a wide variety of lifestyle, cultural and dietary requirements, Kosher and Halal certified, Vegetarian Society approved

• Organic ingredient carrier in Europe

plantcapstm capsulesPullulan capsules, the more natural choice

• All the benefits of gelatin in a vegetarian capsule with the best oxygen barrier properties

• The more natural alternative, starch-free, gluten-free, preservative-free, and non-GMO

• Beautiful, crystal-clear transparency, with high luster – no spotting

• Organic labeling allowed in the U.S. when filled with organic ingredients

• Meets dietary needs, certifications include GRAS status, Halal and Kosher

Capsules for Liquid-fills Application Specific Capsules

dbcaps® capsulesThe unique solution for double-blind clinical trials

• Unique locking mechanism

• Highly efficient over-encapsulation

• Smaller size improves compliance

• Available in gelatin and HPMC

pccaps® capsulesDesigned for humane pre-clinical trials

• Ease administrations and prevent regurgitation & upper GI tract irritation

• Single dosing kit or multi-dosing filler available

press-fit® and xpress-fit® gelcapsExtend the lifecycle of your existing tablet formulations

• Distinct dosage form (high gloss gelatin over caplet core)

• Extensive color choices for market differentiation, brand awareness

licaps® capsulesInnovative and proven concept with unique visual appeal

• Unique filling technology patented by Capsugel

• Innovative solution for lipid-based delivery

• Employs Capsugel’s proprietary Fusion Technology to form a leak-proof, perfectly airtight capsule

• Offers unique multi-phase options for a variety of release profiles

• Ideal for product differentiation

• Consistently preferred by consumers globally

• Available in gelatin and HPMC

sgcaps® softgelsAdd quality to a flexible dosage form

• Proven and convenient technology for both oral and topical applications

• Sizes, shapes and colors can be customized according to product requirements

• Manufactured at the highest quality and safety standards

• Ideal for both the health & nutrition and pharmaceutical markets

drcapstm capsulesThe vegetarian capsule designed to release when you need it

• Protects sensitive dietary supplement ingredients from stomach acidity to ensure maximum benefits

• Acid-resistance without the cost and complexity of coatings

• Maximum taste masking

oceancapstm capsulesMade of highest quality fish gelatin for all marine concepts

pearlcapstm capsulesShiny, iridescent capsules for stand-out sophisticated products

dry powder inhaler (dpi) capsulesCustom engineered to allow more consistent bronchial delivery

• Inner surface properties that minimize powder adhesion to inside wall of the capsule for consistent dose delivery

• Low moisture level shell with optimized puncture properties

• Strict microbial limits that comply with all global DPI regulatory guidelines

• Available in both DPI-specific gelatin or hypromellose capsules

ColorsColor is what the consumer remembers most and so the right color can help you make your mark in the marketplace.

Capsugel’s unique Colorlab and Colormatch service guarantees you optimal satisfaction by ensuring you get the exact capsule color you ordered. And in addition to the hundreds of standard and custom colors Capsugel can provide, we also offer our unique Pearlcaps®, pearlescent colored capsules as well as a full palette of natural colorants as color options.

PrintingCapsule printing opens up a variety of possibilities for uniquely identifying your product by adding information such as:

• Your company or brand logo

• Your brand or product name

• Patient dosage details

Axial, rectified axial and rectified radial printing is all available and can be done with pharmaceutical grade, food grade or even natural inks.

FillingsCapsugel offers a number of innovative filling options, including granules, powders, liquids, semi-solids, and mini tablets. All can easily be filled alone or in combination for a one-of-a-kind product that will attract consumers and patients while meeting your unique formulation and delivery needs.

SizesCapsugel capsules are available in a wide range of sizes.

State-of-the-art Precision Filling Equipment

Customizable Options for Your Product’s Unique Needs

xcelodose® and xcelolab® precision powder micro-dosing systemsShorten drug development time and speedup time to first-in-human clinical trials with these highly consistent cGMP compliant systems that precisely fill capsules and other small receptacles with powders at weights as low as 100µg with an accuracy of 1-2% RSD, eliminating the need for excipients or bulking agents and lowering costs by reducing the need for stability studies.

cfs liquid filling and sealing machinesExploit the potential of lipid-based formulations with these systems designed for liquid and semi-solid filling and sealing of capsules for clinical batch trials. The CFS 1200 bench-top machine is perfect for R&D, filling and sealing up to 1,200 capsules per hour, and the CFS 1500 floor-standing machine has a throughput of 1,500 capsules per hour and allows for easy integration into a suitable containment system.

manual capsule machinesPerfect for R&D labs, small scale runs and compounding pharmacies, our manual capsule machines are available in 100 or 300 hole options and can fill up to 3,000 or 9,000 capsules per hour respectively, while our manual over encapsulator machines facilitate the filling of small batches of DBcaps capsules allowing you to double blind up to 1,500 doses of caplets, tablets or capsules per hour.

commercial scale capsule machinesDesigned for high-speed semi-automatic filling applications, the Ultra 8 II machine can process up to 33,000 capsules per hour and offers numerous operational safety features that streamline the production process. Also available is the CAP 8 machine, a reliable and affordably priced semi-automatic capsule filling machine with unique safety features and throughput rates of up to 29,000 capsules per hour.

Size 0

Size 2

Size 3 Size 4 Size 5

Size 1 elongated

Size 1

Size 00 elongated Size 00

Size 0 elongated

Size 2 elongated

Size 000

Capsugel’s Global Footprint Ensures Certainty of Supply Our customers span the world, and so does Capsugel. Each year we produce close to 200 billion capsules for more than 4,000 customers in over 100 countries. Our vast production capacity helps us effectively respond to changing marketplace demands no matter where our customers are located – providing you with the peace of mind that your dosage-form requirements will be met rapidly and with world-class quality.

Capsugel operates 24x7 in manufacturing locations, state-of-the-art Product Development Centers and multiple business offices around the world.

To work together or learn more, contact us at capsugel.com

MorristownNew Jersey

BostonMassachusetts

Rio de JanerioBrazil

BornemBelgium

PueblaMexico

GreenwoodSouth Carolina

StrasbourgFrance

PloërmelFrance

ColmarFrance

DelhiIndia

SuzhouChina

SagamiharaJapan

Hong KongChina

BangkokThailand

JakartaIndonesia West Ryde

Australia

Our global presence, industry-leading capsule products, and innovative drug delivery technologies translate into shorter go-to-market time for Capsugel customers.

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Current Capsugel customers have access to personalized technical and ordering information at mycapsugel.com. Contact your sales representative for more details.