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INSTITUTE OF PARASITOLOGY

ANNUAL REPORT 2007 - 2008

Prepared by Professor Timothy G. Geary

Director August 2008

Murine brain cell infected with the parasite, Toxoplasma gondii

Institute of Parasitology 2007-2008

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Cover

Corresponding article: Dziereszinski, F. et al., Infection and Immunity 75: 5200-5209, 2007. Figure legend: Presentation of a Toxoplasma gondii antigen by brain cells (astrocytes). Blue: astrocyte and parasite nuclei. Green: MHC-I molecule/T. gondii antigen complexes.

Credit: The photo was taken from “Infection and Immunity” November 2007, volume 75 (Copyright © 2007, American Society for Microbiology. All Rights Reserved.)


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I – Mission & Objectives

• To train students and highly qualified personnel at an advanced level in all of the life science disciplines relevant to the host-parasite relationship • To advance knowledge in the life science disciplines relevant to the host-parasite relationship • To undertake basic research aimed at reducing morbidity and mortality caused by parasite infections in animals and humans • To communicate our findings to the scientific community and the general public • To contribute our expertise to the broader mission of McGill University through our teaching, research and service in the life sciences in the Faculties of Agricultural and Environmental Sciences, Medicine, and Science, particularly in relation to Biotechnology and the Environment

II – Highlights of Past Year’s Activities

► In August 2007, The Institute of Parasitology celebrated 75 years as the only Institute of its kind in North America. In an area of increasing public awareness and interest, McGill has recognized the importance of the Institute and the world class research carried out here with its continued support, both in terms of infrastructure and new staff appointments. In addition to its world-wide reputation, the Institute acts as a “virtual” anchor for Parasitology in Quebec. As the founding member of the FQRNT/McGill funded “Centre for Host-Parasite Interactions”, it brings together researchers from research institutions through the Province. The 75th Anniversary, marked by a Public Anniversary Symposium, Parasites and Us, represented a significant chapter in the Institute’s long and distinguished history. Prof. Peter Hotez, from the School of Tropical Medicine, George Washington University, USA, was a prestigious invited guest speaker and gave a talk on “Neglected Tropical Diseases: Prospects for their Control”. McGill Professor Marilyn Scott also gave a talk entitled “Multiple infection: an understated reality”, as did Dr. Brian Ward of the Montreal General Hospital Research Institute on “Human Parasitology: People & Organisms on the Move in 2007”.

► Prof. Timothy G. Geary completed his first full year as Director of the Institute of Parasitology, and continues to serve. This five-year appointment commenced 1 April 2007. Prof. Geary served as the Chair of both the Chemotherapy session, and the Anthelmintic Resistance session, at the World Association for the Advancement of Veterinary Parasitology (WAAVP) Annual Meeting, held in Ghent, Belgium, in August 2007, as well as the Chair of the Novartis Symposium and was a Plenary Lecturer in the Pfizer Symposium at the WAAVP. Prof. Geary was a Plenary Lecturer at the British Society for Parasitology Annual Meeting in Newcastle, England, in April 2008. Prof. Geary also continues as a Tier 1 Canada Research Chair in Parasite Biotechnology. ►Prof. Terry Spithill resigned from McGill, as of December 31st, 2007, to take up a prestigious Research Chair in Veterinary Parasitology at Charles Sturt University. Prof. Spithill held a Tier


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1 Canada Research Chair in Immunoparasitology until December 2007. With permission from the Provost, a recruitment effort was launched to identify a suitable replacement for this senior position and CRC Chair. ► Prof. Gaétan Faubert retired on 30 June 2008, after 33 years of service to the Institute of Parasitology and McGill University. Dr. Faubert taught immunology on both campuses; his lectures were always well received and well appraised by the students. ► The Institute’s Faculty Lecturer, Dr. Jim Smith, retired on 31 August 2007, after 25 years of service to the Institute of Parasitology. Prof. Robin Beech replaced Dr. Smith as the Graduate Program Director, and Prof. Paula Ribeiro replaced Jim as Chair of the Institute’s Scholarships Committee. ►Assistant Professor Florence Dzierszinski, who joined the Institute in December 2006, continues to hold a prestigious Tier 2 Canada Research Chair in Parasite Pathogenesis as well as supporting funds from the Canada Foundation for Innovation. During the time frame of this report, Dr. Dzierszinski received a 2-yr March of Dimes grant, plus 5-yr funding from NSERC. ►Prof. Marilyn Scott was appointed Director of the McGill School of the Environment as of 1-June-2008. This is a 5-year appointment. ►Prof. Roger Prichard organized an International Consortium for Anthelmintic Resistance in Ghent, Belgium, in August 2007, and was invited, with Prof. Geary, by the journal Nature to write a News & Views article on new drug development. Prof. Prichard’s work on a vaccine for African trypanosomiasis (sleeping sickness), a serious disease caused by a parasite that is endemic in many parts of Africa, is funded by a Gates Foundation grant. Prof. Prichard also continues as a James McGill Chair (2003-2010), and continues to serve Dean Madramootoo as Chair of the Faculty Planning Committee for the Faculty of Agricultural and Environmental Sciences. ► Prof. Georges continues as Director of the Institute’s Biotechnology Program. The Biotechnology program continues to receive more applications than there are available spaces in the program. In September 2007, the number of non-thesis Biotechnology students increased significantly from the previous year’s enrolment. Since the launch in 2005 of the M.Sc. (Applied) degree in Biotechnology, demand for this program has been strong and continues to grow. There is a waiting list for the M.Sc.(A) Biotech program. Expansion in this hot area is hampered by lack of lab space. ► Dr. David Marcogliese, from Environment Canada, St. Lawrence Centre, was appointed as an Adjunct Professor to the Institute of Parasitology in March 2008. This is a 3-year appointment. Dr. Marcogliese collaborates with Dr. Marilyn Scott and complements her research program on environmental issues. ► New Structural Bioinformatics course: For the first time on the Macdonald Campus, a Structural Bioinformatics course was offered in 2007. Assistant Professor Reza Salavati was the course coordinator. The course was well received by the first cohort of students, and has been accepted by the McGill Centre for Bioinformatics as an elective for the Bioinformatics option across the University.


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► New Functional Genomics course: Prof. Geary developed and launched a new Functional Genomics course in September 2007. This was the first time that students had the opportunity to study functional genomics on the Macdonald Campus. ► New course on Water-Borne Health Hazards: Professors Faubert and Geary delivered a course on Water-borne Health Hazards as part of the Water Resource Engineering program in 2007; this illustrates the continuing commitment of the Institute of Parasitology to other Macdonald programs, such as the Brace Water Institute. ►The Institute of Parasitology completed its fifth year as the Leader for the FQRNT Centre for Host-Parasite Interactions. With the departure from McGill of Terry Spithill, a new director for the Centre was identified. Prof. Armando Jardim agreed to serve. The Quebec government will continue to fund the Centre for 1 more year in the current round. Then, the Centre must apply for renewal, and compete in the highly competitive funding arena. ► Dr. Manami Nishi joined Prof. Dzierszinski’s group as of 1 June, 2007, as a postdoctoral fellow. She hails from the Japan, and won a prestigious PBEEE (Programme de bourses d’excellence pour étudiants étrangers) funding award from the Quebec government. She will be conducting novel research for the identification and purification of cyst wall proteins in Toxoplasma gondii, using proteomic approaches. ► Dr. Rodrigo Miranda from Brazil joined Prof. Prichard’s laboratory in Feb. 2008 as a postdoctoral fellow. He holds a Canadian Postdoctoral Research Fellowship, tenable in Canada. Dr. Miranda will be investigating the mechanisms of drug resistance in parasitic nematodes. ► Postdoctoral fellow Dr. Catherine Bourguinat joined Prof. Prichard’s lab in October 2007. She will work in Africa on Onchocerca volvulus, including studies in the field in Cameroon. Dr. Bourguinat is conducting research to discover a possible genetic marker to follow potential ivermectin resistance in Onchocerca volvulus. We have recently learned, with dismay, that Catherine has contracted malaria while conducting research in Africa. She is currently undergoing treatment in Cameroon. ► Postdoctoral fellow Joseph Nabhan left the laboratory of Prof. Geary on 31 October 2007 to continue his postdoctoral research at Harvard. ► Dr. Anne Schwab (working in Prof. Geary’s lab) holds an FQRNT postdoctoral fellowship at the Université de Montréal Veterinary School at Saint-Hyacinthe, but she continues to collaborate with veterinary parasitologists and molecular biologists at the Institute of Parasitology. ► Ms. Stephanie Goyette (PhD candidate in the lab of Prof. Dzierszinski) won a CIHR doctoral fellowship, and Ms. Carlie Halpenny, in the laboratory of Prof. Scott, won an NSERC doctoral fellowship. Jonathan Solomon, in the lab of Prof. Geary, won a master’s FQRNT fellowship, and Nicholas Patocka, working with Prof. Ribeiro, was awarded an FQRNT doctoral fellowship. In the laboratory of Prof. Prichard, Vijay Rao won an FQRNT doctoral fellowship, and Andrea Rauba was awarded an NSERC Master’s fellowship.


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►The Institute offered in 07/08 a Flow Cytometry Core Facility as well as a Molecular Biology Service Facility to the McGill community, the FQRNT Centre, and industry. The Institute also offered biohazard waste disposal for the entire Faculty. The continuation of these services is being called into review, due to lack of funding for a dedicated technician. Teaching and Learning (undergraduate and graduate): Student Success

A. Undergraduate – Although the Institute has no undergraduate program of its own, Institute professors taught basic life sciences to students in several required courses on the Macdonald Campus and in the Faculty of Medicine. As per Senate policy, numerical data from course evaluations are available to McGill students and staff via University postings by the Office of the Provost on the web each term. See http://www/mcgill.ca/provost/courseevaluations/ (see Activity Reports for individual scores).

B. Graduate – The Institute graduated 4 Ph.D. students (Drs. A. Abdul-Wahid, C.

Bourguinat, C. Ivory, L. Purcell) and 2 Master’s students (A. Diawara, M. Nyisztor) in our thesis research degree programs in 2007/08. Dr. Abdul-Wahid accepted a postdoctoral position with Prof. J. Gariépy at the Princess Margaret Hospital, University of Toronto Health Centre, working on a colono-rectal cancer vaccine. Dr. Bourguinat continued on at McGill as a postdoctoral fellow with Prof. Prichard working on Onchocerca volvulus. Dr. Purcell was nominated for a Canadian Association for Graduate Studies Distinguished Dissertation Award and a Prix d’Excellence de l’Association des Doyens des Études Supérieures au Québec. Dr. Purcell accepted a postdoctoral position at Columbia University in New York, continuing her work in the field of malaria. Of our 2 M.Sc. graduates, Mr. Nyisztor found employment as a Food Safety Inspector in Québec, and Ms. Diawara returned to McGill to undertake doctoral research. Doctoral candidate Nicholas Patocka serves as the Manager of the Ceilidh Club, run by the Students’ Society, on the Macdonald Campus. He was last year’s winner of the Gold Key Award for participation in student life on the Macdonald Campus, and holds an FQRNT doctoral fellowship. Doctoral candidate Lisa Purcell won a travel award to attend the American Society for Tropical Medicine and Health 56th Annual Meeting in Philadelphia, PA, November 4-8, 2007. Ms. Purcell was further honored by the ASTMH by winning a Young Investigator award for her work on malaria.

C. In the non-thesis Biotechnology program, 1 student graduated with a Certificate in

Biotechnology, and the new M.Sc. Applied in Biotechnology program graduated its third cohort of 9 students. The biotech industry is an eager employer for these well trained graduates. Graduates have found jobs at a number of Biotech/Pharma companies (Merck Frosst, MethylGene, Covance, Charles River, Ontario Public Health, to name a few), or have accepted research assistant positions at universities, while other graduates decided to continue into a Ph.D. program.


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Visiting students – Mr. Pramote Sriwanitchrak, Ph.D. student from Thammasat University, Thailand, was a visitor in the laboratory of Prof. Spithill from 1 April – 30 September 2007. Ms. Catherine James, Ph.D. student from the University of Technology in Sydney, Australia, joined the laboratory of Prof. Prichard from 1 April to 31 July, 2007.

D. Summer students- Five undergraduate students were employed at the Institute during

the summer of 2007 and all received advanced research training in laboratory techniques. Three students worked at the Institute as part of a Government of Canada Summer Careers Placement Program in Prof. Beech’s lab (Mr. John Lee, McGill), Prof. Georges’ lab (Ms. Melissa Richard-Lalonde, McGill) and Prof. Dzierszinski’s lab (Ms. Allison Nicholls, University of Victoria, B.C.). One NSERC Undergraduate Summer Research Awardee, Ms. Valerie Hongoh, spent the summer in the lab of Prof. Marilyn Scott. Prof. Jardim hired Ms. Sarah Lalonde as an undergraduate lab assistant during the summer of 2007. The Institute exposed all these trainees to cutting edge research in molecular biology, immunology, proteomics, and population studies in the life sciences.

E. Visiting Scientists – Dr. Rafael Perez from Spain spent two months at the Institute

working in Prof. Spithill’s lab. Dr. Thidarut Boonmars arrived at the Institute on the 18th of June 2008 from Khon Kaen University, Thailand. A veterinarian, she will work with Profs. Prichard and Geary on the molecular analysis of two populations of a nematode parasite of humans, Strongyloides stercoralis, a liver fluke which can cause cholangiocarcinoma. The Institute also welcomed another veterinarian, Dr. Ibtisam Goreish, from Sudan. Dr. Goreish is the Head of the Parasitology Department at the Central Research Laboratories in Khartoum, Sudan. Funded by the UN, she came to the Institute to learn techniques for expressing recombinant vaccine proteins from Fasciola gigantica, with the aim of producing proteins for vaccine trials in Sudan in 2008-09. Dr. Angela Mousley, from Queen’s University, Belfast, Northern Ireland, arrived as a visiting scientist on 29 August 2007. She worked for a few months in the laboratory of Prof. Geary on confocal microscopy of parasites.

F. Training – In March 2008, research technician Ms. Kristi Bangs attended a week-long

operator training course on high platform Facs Aria techniques offered exclusively in North America by BD Sciences at San Jose, California. The Institute was then able to offer Flow Cytometry and Confocal Microscopy services to the entire Faculty, FQRNT Centre, and industry. Unfortunately, Ms. Bangs subsequently decided to leave the University and salary support for the position will be lost with the end of CFI-funding in March 2009.

Research assistant Dr. Kebba Sabally went on a training trip to Craft Technologies in Wilson, North Carolina, USA, funded by the Centre for Host-Parasite Interactions.

G. The Institute welcomed two academic trainees. Ms. Sonia Edaye, from Benin, worked

with Prof. Elias Georges from 1 July through to the end of November 2007. Ms. Patricia Velludo, from Brazil, joined the laboratory of Prof. Prichard as an academic trainee from 24-Aug.-14 Dec. 2007.


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H. Guest Lecturers - During the 2007-2008 reporting year, the following distinguished scientists have given invited seminar presentations at the Institute:

Dr. Marco Albonico Ivo de Carneri Foundation, Milan, Italy Topic: “Development of BZ resistance in soil-transmitted nematodes: the threat to humans” Dr. Jon Boyle Department of Microbiology & Immunology, Stanford Univ. School of Medicine, USA Topic: “Secreted protein kinases determine virulence in the human pathogen Toxoplasma gondii” Dr. Kelly Chibale Institute of Infectious Diseases and Molecular Medicine, University of Capetown, South Africa Topic: “Drug discovery in an African institution: Harnessing the power of modern technology and natural resources” Dr. John Dalton Institute for Biotechnology, University of Technology, Sydney, Australia Topic: “Plasmodium falciparum neutral aminopeptidases: valid targets for new antimalarial drugs” Dr. Silvina Fernández Department of Pathobiology, Ontario Veterinary College, University of Guelph, On Topic: “Epidemiology and control of helminth parasites in livestock” Dr. Denis Gaucher Département de microbiologie et immunologie, Université de Montréal, Qc Topic: “Correlates of protection: the immune response to yellow fever vaccination” Dr. Marc-Jan Gubbels Department of Biology, Boston College, USA Topic: “Genetic dissection of Toxoplasma gondii host cell invasion and division”

Dr. Rebecca Guy Université de Montréal Veterinary School, St. Hyacinthe, Qc Topic: “Molecular characterization of parasitic protozoa in aquatic environments” Dr. Ron Kaminsky Head of Parasitology, Novartis Animal Health, Switzerland Topic: “AADs, a new class of anthelmintics effective against drug-resistant nematodes” Dr. Scott Landfear Department of Molecular Microbiology and Immunology, Oregon Health Sciences University, USA Topic: “An essential role for glucose transporters in Leishmania parasites” Dr. Oliver Liesenfeld Institute of Microbiology and Hygiene, Charité Medical School, Berlin, Germany Topic: “Interaction of Toxoplasma gondii with host barrier sites–from gut to brain”


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Dr.Stephen Michnick Département de Biochimie, Univ. de Montréal, Qc Topic: “The dynamics of protein interaction networks in living cells”

Dr. Christian Raccurt École de médecine, Université de Picardie-Jules Verne, France

Topic: “Geohelminthiasis in school children in Haiti” Dr. Michael Reed Montreal General Hospital Research Institute, Qc Topic: “Mycobacterium tuberculosis – does pathogenic diversity exist?”

Dr. Ana Rodriguez New York University School of Medicine, Medical Parasitology, NY, USA Topic: “Plasmodium infection and immune response: from the liver to the blood”

Dr. Petra Rohrbach School of Medicine, University of Heidelberg, Germany Topic: “Live cell imaging of Plasmodium falciparum: shedding light on ion homeostasis and multi-drug resistance” Dr. Ana Sanchez Brock University, On Topic: “The epidemiology of Taenia solium in Honduras” Dr. Meiqing Shi Department of Microbiology and Infectious Diseases, University of Calgary, Ab Topic: “Experimental African trypanosomiasis: role of IFN-gamma and IL-10 in immunopathogenesis” Dr. Jude Uzonna University of Manitoba, Mn Topic: “Regulation of immunity to Leishmania major: from induction to immunologic memory”

Dr. David Waltner-Toews Department of Population Medicine, Univ. of Guelph, On Topic: "Between Parasites and Planets: Science in the Muddled Middle" Dr. Gary Ward Department of Microbiology and Molecular Genetics, Univ. of Vermont, USA Topic: “A small molecule approach to studying host cell invasion by Toxoplasma gondii”

Dr. Jeff Williams Chief Technology Officer, HaloSource, Seattle, Wa, USA Topic: “New water treatment technologies: making water safer for salmon, swimmers, and slum dwellers” Dr. Adrian Wolstenholme Department of Biology and Biochemistry, University of Bath, UK Topic: “Current progress towards understanding anthelmintic action and resistance”

Our students and trainees benefited enormously from contact with these leaders in their fields.


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Research: Discoveries and innovations The Institute’s research was published in 34 papers in peer-reviewed Journals and was presented at 46 conference presentations. Professors gave 29 invited presentations during the 2007/08 reporting period. Collaborations The Institute is active in multiple international and national collaborations. (See individual Activity Reports for precise listing of collaborations.) Equipment grant Profs. Scott, Wykes and Koski received an NSERC Research Tools and Instruments award worth $66,844, (2007-2008), for a bioplex system for multiplexing microassays of biomarkers. New research initiatives from the McGill Centre for Host-Parasite Interactions, based at the Institute of Parasitology Prof. Beech received an FQRNT Centre New Initiatives grant with Profs. R. Prichard, J. Dent and T. Geary, to study “Development of transgenic parasitic nematodes”. Prof. Dzierszinski received an FQRNT Centre New Initiatives grant with Prof. A. Jardim and Dr. M. Desjardins, to study “The pathogenesis of Toxoplasma gondii: PVM protein identification”. Prof. Ribeiro is collaborating with Prof. J. Dent studying “Neuronal control of nematode development” with funding from an FQRNT Centre New Initiative Award. Prof. Salavati received an FQRNT Centre New Initiatives grant with Prof. G. Berghius, to study “The architecture of trypanosomatids”. Prof. M. Stevenson at McGill’s Centre for the Study of Host Resistance received an FQRNT Centre New Initiatives grant with Profs. T. Geary and C. Piccirillo for the project “Multidisciplinary strategy to identify immunosuppressive compounds”. Dr. M. Tremblay, with Dr. M. Ouellette, at Université Laval received an FQRNT Centre New Initiatives grant for a project entitled “Use of HIV-1 protease inhibitors as anti-leishmanial compounds”. The Centre for Host-Parasite Interactions is maturing and expanding its research programs. It is a vehicle for driving new initiatives across Quebec, where several Centre members will come together to start new collaborative research, often with international linkages. This process is ongoing. Other international activities

• Our Centre for Host-Parasite Interactions held its 7th Annual Quebec Parasitology Symposium during the time span of this report (see FQRNT section, pg. 14). It was held at Université de Québec à Montréal in May 2008. Several international visitors attended.


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• Prof. Prichard served as the Principal Coordinator for the International Consortium for Anthelmintic Resistance SNPs Workshop, which was held in Ghent, Belgium, in August 2007. • Prof. Geary chaired the Chemotherapy session of the North American Parasitology Conference held in Yucatan, Mexico, in June 2007. Academic Staff: The list of academic staff as of June 1, 2007, is shown in Appendix IV. Dr. Spithill resigned from McGill University as of 31 December 2007. Departures – Prof. Terry Spithill accepted a Research Chair in Veterinary Parasitology at Charles Sturt University in Australia and left McGill in December 2007. Prof. Gaétan Faubert retired on 30 June 2008. The Provost has given the Institute of Parasitology permission to recruit to fill these two vacant positions. Faculty Lecturer, Dr. James Martin Smith, also retired during the time frame of this report. New Hires – Two new hires have been made: (1) Dr. Petra Rohrbach from Heidelberg University in Germany accepted an Assistant Professor position at the Institute of Parasitology, and will commence work in Nov. 2008. She will work on drug resistance in the important human malaria parasite Plasmodium falciparum, which is closely tied with water through its vector, the mosquito. (2) Dr. John Dalton from Australia has accepted a Full Professor position and will come to McGill in May 2009. He will be applying for a Tier 1 Canada Research Chair in Immunoparasitology. Dr. Dalton will conduct basic research on the biochemistry / immunology of parasites and diseases caused by parasites, with an emphasis on helminths and malaria. His background in international health, with collaborations in Southeast Asia, will help the Institute develop greater strength in this important area. Chairs – Prof. Prichard continues to hold a James McGill Chair, which supports his extensive international research program in molecular helminthology. Prof. Dzierszinski won a Tier 2 Canada Research Chair in Parasite Pathogenesis; this supports her research program. Prof. Geary continues in his Tier 1 Canada Research Chair in Parasite Biotechnology. Assoc. Prof. Robin Beech – Prof. Beech accepted to be the Graduate Program Director for the Institute’s M.Sc. and Ph.D. degree programs. He also served on the Local Organizing Committee for the 46th Annual Meeting of the Canadian Society of Zoologists. Assistant Prof. Florence Dzierszinski – Prof. Dzierszinski received a Basil O’Connor Starter Scholar Research Award from the March of Dimes Foundation in December 2007. She also serves on the Library Committee and the Small Animal Users’ Committee for the Faculty of Agricultural and Environmental Sciences. Prof. Dzierszinski represented the Institute of Parasitology at the Dean’s Donor Reception in April 2008. Prof. Faubert – Prof. Faubert retired on 30 June 2008, after 33 years of service to McGill University. In May/June 2008, he assisted Dr. T. Scorza of Université de Québec à Montréal as co-Chair to organize the Molecular Parasitology Symposium of the FQRNT/McGill Centre for Host-Parasite Interactions.


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Prof. Geary – Prof. Geary served on McGill’s Technology Transfer Committee and on the Macdonald Campus Recruitment Committee for a Chair of the Animal Science department. He is a member of the Nominating Committee of the American Association of Veterinary Parasitologists, and the Industrial Liaison Committee for the American Society of Parasitologists. Prof. Geary holds a Tier 1 Canada Research Chair in Parasite Biotechnology and was awarded in 2006 a 5-yr NSERC grant. Assoc. Prof. Elias Georges – Prof. Georges served on the Board of the McGill spin-off biopharmaceutical company, Aurelium Biopharma Inc. He also served as a member of the Macdonald Campus Development Committee. He is Director of the Biotechnology Program at the Institute. Prof. Georges filed several US patent applications related to “ABP-Directed Diagnostics for Neoplastic Disease” during the time frame of this report. Assoc. Prof. Jardim – Prof. Jardim agreed to succeed Prof. T.W. Spithill as the Director of the FQRNT/McGill Centre for Host-Parasite Interactions. Prof. Jardim also serves the Institute as Manager of the Parasitology Molecular Biology Core Facility. Prof. Prichard – Prof. Prichard served on the Local Organising Committee for the Canadian Society of Zoologists in 2007. Prof. Prichard chairs the Faculty of Agricultural and Environmental Sciences’ Faculty Planning Committee, and the Faculty Nominating Committee. Prof. Prichard was invited to write an article for the journal Nature. Assoc. Prof. Ribeiro – Prof. Ribeiro has served as the Chair of the Macdonald Campus Safety Committee as well as the Institute of Parasitology’s Safety Committee since January 2006. Prof. Ribeiro chairs the Institute of Parasitology’s Scholarships Committee and Curriculum Committee. Assistant Professor Salavati – Since his arrival in December 2005, Prof. Salavati has focused his efforts on the development of a Structural Bioinformatics course and the setting up of his research laboratory. He was the recipient of an NSERC Discovery Grant, an NIH Grant, and a CIHR grant. He serves on the Faculty IT Committee. Assoc. Prof. Marilyn Scott –Prof. Scott served as the Chair of the Graduate Affairs Committee for the McGill School of the Environment. As of 1 June 2008, Prof. Scott has accepted to become the Director of the McGill School of the Environment. She was also the director of the McGill Quebec-Panama Consortium, and a member of the Faculty Working Group on Teaching Excellence. Dr. Jim Smith – Dr. Smith retired on 31 August 2007, after having received an Award in May 2007 for 25 Years of Service to McGill University. Prof. Terry Spithill – Prof. Spithill resigned, as previously mentioned, effective 31 Dec. 2007, to take up a Research Chair, and rejoin his family, in his native Australia. Prof. Spithill was elected President of the Australian Society of Parasitology, 2008-2010. He was appointed an Adjunct Professor at McGill and continues to collaborate with researchers at the Institute.


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Involvement in the Community: Institute faculty served the academic and wider community in multiple ways. All staff serve on a variety of Faculty and McGill Committees, review journal articles and PhD/MSc theses, and organize conferences, as detailed in the Activity Reports. Some particular involvement is highlighted here. The Montreal Eureka! Festival was held in the Old Port of Montreal from the 15th to the 17th of June 2007. This was the first of what is to become an annual event, and its purpose was to introduce science to the general public and school children in the Montreal area. The Institute of Parasitology/Centre for Host-Parasite Interactions was one of only three McGill units to participate in this well organized event. Three laboratories from the Institute, including professors and students, participated in this event and provided lots of interesting ideas to Montrealers, which were well received by the public. Staff from the Institute of Parasitology, and other McGill departments, contributed to the Drug Resistance in Parasites (COST) meeting organized by the Centre de Recherche en Infectologie de l’Université Laval, in Quebec City, 22-24 October 2007. Drs. Peter Hotez (George Washington School of Tropical Medicine), Brian Ward (Montreal General Hospital Research Institute) and Marilyn Scott (McGill School of the Environment) presented talks on August 11th, 2007, at a Public Lecture to mark the 75th Anniversary of the Institute of Parasitology. This was followed by a reception for friends of Parasitology, staff and students McGill-wide. These talks were open to the public and the entire McGill community. Dr. Jim Smith, until his retirement, responded to a wide assortment of questions about parasites from the general public, students, university teachers, and the media, and maintained the following web pages for public access: The World of Parasites http://martin.parasitology.mcgill.ca/jimspage/worldof.htm Parasitism and Associations http://martin.parasitology.mcgill.ca/jimspage/biopage/parasit.htm The Power and Versatility of in situ Hybridization http://martin.parasitology.mcgill.ca/insituhybridization/index.htm Cell Structure and Function http://martin.parasitology.mcgill.ca/jimspage/cellbiol/cell.htm


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III – FQRNT Centre for Host-Parasite Interactions Centre de recherche sur les interactions hôte-parasite

In 2007-2008, our Provincially-funded Regroupement Stratégique Centre completed its fifth busy year of operation. Please visit the website www.mcgill.ca/chpi for details of our scientific activities, and services offered, throughout the Centre. The Centre for Host-Parasite Interactions brings together researchers and their trainees at the Institute of Parasitology, Department of Microbiology and Immunology, Department of Biology, Department of Chemistry, Department of Epidemiology and Biostatistics, Department of Physiology, Department of Chemical Engineering, Department of Bioresource Engineering, School of Dietetics and Human Nutrition, Brace Research Institute, McGill Centre for Tropical Medicine and the McGill University Health Centre, at McGill University, Université de Montréal, Centre de recherche en Infectiologie, Université Laval, INRS – Institut Armand-Frappier, and Université du Québec à Montréal into what is considered by external reviewers as the strongest centre for parasitological research in the world. It is recognized as an FQRNT Regroupement stratégique. The research of the Centre focuses on Mechanisms of Pathogenesis and Host Defense to Parasite Infections, and the Molecular Basis of Anti-parasite Drug Resistance and Drug Discovery. This cross fertilization is also of great benefit to the approximately 108 trainees in the Centre. As a result of the Centre, there have been over 60 joint publications from Centre members and trainees over the last 2 years and numerous collaborative research grants and contracts. The Centre has received international recognition by being invited to participate with networks or centres of excellence in other parts of the world in joint collaborative projects. Each year the Centre holds several research meetings involving all members of the Centre. The Annual two-day Scientific Meeting typically involves 50 – 60 oral and poster presentations and invited international experts. This year, a Molecular Parasitology Symposium was held at Université de Québec à Montréal from June 12-13, 2008. Plans are underway for next year’s meeting at Université de Montréal à St-Hyacinthe. In addition to the Annual Scientific Meeting, a meeting was held to review progress on New Initiative projects funded by the Centre as well as a meeting to plan more joint applications within the Centre, for external grants. The Centre is vibrant and adds tremendous value to the research and training efforts of its members.


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IV – Challenges

We are confident that the future of the Institute of Parasitology is incredibly bright, but we sense that it is approaching a cross-road. The Institute has gone through a significant growth period since the year 2000, with several major CFI Awards, three CRC Awards, the FQRNT Centre Award, and the establishment of a Biotechnology graduate program. Unfortunately, infrastructure funding and support staff appointments have not kept pace with growth. We are struggling to identify new sources of funding that will enable us to maintain our considerable momentum. This applies especially to the area of high technology platform instrumentation made possible by CFI wins, which have high maintenance costs associated with them as well as requiring dedicated highly skilled technicians for optimal operation of the instruments. The sustainability of our present high level of operation is coming into question. The Institute would greatly benefit from more University support to maintain its operations at this demonstrable high level of success. The Biotechnology graduate program, as it continues to grow, is also in need of its own operating budget. We look forward to working with the University and potential outside sources to resolve these issues. The Institute of Parasitology celebrated its 75th Anniversary in August 2007. We look forward to the challenge of another 75 years of research excellence, teaching, and service to the University. We aspire that the Institute of Parasitology will continue to make significant contributions to the study of parasitology worldwide, and to fulfill its mandate to graduate highly skilled professionals in our domain.


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APPENDIX I

HONORS, AWARDS, PRIZES

Prof. Florence Dzierszinski • Tier 2 Canada Research Chair in Parasite Pathogenesis, 2007-2012 Prof. Timothy G. Geary • Tier 1 Canada Research Chair in Parasite Biotechnology, 2005-2012 Prof. Armando Jardim • CIHR New Investigator Award, 2003-2008 • Director of the FQRNT Centre for Host-Parasite Interactions, 2008-2009. Prof. Roger Prichard • James McGill Chair, 2003-2010 • Elected Fellow, Australian Society for Parasitology • Honorary Fellow, European Veterinary Parasitology College Prof. Marilyn Scott

• Twenty-five year Service to McGill Award, at Staff Relations Reception, May 2007 • Appointed Director of the McGill School of the Environment, 2008-2013.

Prof. T. Spithill • Tier 1 Canada Research Chair in Immunoparasitology, 2002-2008


17

APPENDIX II PUBLICATIONS

Between January 1, 2007 and December 31, 2007


For electronic version of Institute of Parasitology publications for 2007, we refer you to the following website: www.mcgill.ca/parasitology/publications/


18

INSTITUTE OF PARASITOLOGY List of All Academic Staff Members: Robin N. Beech, Florence Dzierszinski; Gaétan Faubert; Timothy Geary; Elias Georges; Armando Jardim; Roger Prichard; Paula Ribeiro; Reza Salavati; Marilyn E. Scott; Terence W. Spithill List of Students at the Institute of Parasitology See Post-graduate Student Enrolment in Appendix IV. Publications between January 1 and December 31, 2007 Beech, R.N. (Gilleard, J.S. and Beech, R.N.) Population genetics of anthelmintic resistance in parasitic nematodes. Parasitology 134: 1133-1147, 2007. -(Jia, X., Ebine, N., Demonty, I., Wang, Y., Beech, R., Muise, V., Fortin, M.G. and Jones, P.J.H.) Hypocholesterolaemic effects of plant sterol analogues are independent of ABCG5 and ABCG8 transporter expressions in hamsters. British Journal of Nutrition 98: 550-555, 2007. Dzierszinski, F.D. (Dzierszinski, F., Pepper, M., Stumhofer, J.S., LaRosa, D.F., Wilson, E.H., Turka, L.A., Halonen, S.K., Hunter, C.A. and Roos, D.S.) Presentation of Toxoplasma gondii antigens via the endogenous major histocompatibility complex class I pathway in nonprofessional and professional antigen-presenting cells. Infection and Immunity 75: 5200-5209, 2007. -(Menard, L.C., Minns, L.A., Darche, S., Mielcarz, D.W., Foureau, D.M., Roos, D., Dzierszinski, F., Kasper, L.H. and Buzoni-Gatel, D.) B cells amplify IFN-γ production by T cells via a TNF-α-mediated mechanism. The Journal of Immunology 179: 4857-4866, 2007. -(Sarry, J.-E., Chen, S., Collum, R.P., Liang, S., Peng, M., Lang, A., Naumann, B., Dzierszinski, F., Yuan, C.-X., Hippler, M. and Rea, P.A.) Analysis of the vacuolar luminal proteome of Saccharomyces cerevisiae. The FEBS Journal 274: 4287-4305, 2007. Faubert, G.M. (Abdul-Wahid, A. and Faubert, G.) Mucosal delivery of a transmission-blocking DNA vaccine encoding Giardia lamblia CWP2 by Salmonella typhimurium bactofection vehicle. Vaccine 25: 8372-8383, 2007. Geary, T.G. (Mackenzie, C., Geary, T., Prichard, R. and Boussinesq, M.) Where next with Loa loa encephalopathy? -Data are badly needed! Trends Parasititol. 23: 237-238, 2007. -(Woods, D.J., Lauret, C. and Geary, T.G.) Anthelmintic discovery and development in the animal health industry. Expert Opinion on Drug Discovery 2(S1): 1-9, 2007.


19

-(Omar, H.H., Humphries, J.E., Larsen, M.J., Kubiak, T.M., Geary, T.G., Maule, A.G., Kimber, M.J. and Day, T.A. ) Identification of a platyhelminth neuropeptide receptor. International Journal for Parasitology 37: 725-733, 2007. -see also PRICHARD, R.K. Georges, E. The P-glycoprotein (ABCB1) linker domain encodes high-affinity binding sequences to alpha- and beta-tubulins. Biochemistry 46: 7337-7342, 2007. -(Laberge, R.M., Karwatsky, J., Lincoln, M.C., Leimanis, M.L. and Georges, E.) Modulation of GSH levels in ABCC1 expressing tumor cells triggers apoptosis through oxidative stress. Biochemical Pharmacology 73: 1727-17437, 2007. -(Leimanis, M.L. and Georges, E.) ABCG2 membrane transporter in mature human erythrocytes is exclusively homodimer. Biochemical and Biophysical Research Communications 354: 345-350, 2007. Prichard, R.K. Markers for benzimidazole resistance in human parasitic nematodes? Parasitology 134, Special Issue 08: 1087-1092, 2007. -Ivermectin resistance and overview of the Consortium for Anthelmintic Resistance SNPs. Expert Opin. Drug Discov. 2(Suppl. 1): S41-S52, 2007. -(Schwab, A.E., Churcher, T.S., Schwab, A.J., Basáñez, M.G. and Prichard, R.K.) An analysis of the population genetics of potential multi-drug resistance in lymphatic filariasis due to combination chemotherapy. Parasitology 134: 1025-1040, 2007. -(Osei-Atweneboana, M.Y., Eng, J.K.L., Boakye, D.A., Gyapong, J.O. and Prichard, R.K.) Prevalence and intensity of Onchocerca volvulus infection and efficacy of ivermectin in endemic communities in Ghana: a two phase epidemiological study. Lancet 369: 2021-2029, 2007. -(Prichard, R.K., von Samson-Himmelstjerna, G., Blackhall, W.J. and Geary, T.G.) Foreword: Towards markers for anthelmintic resistance in helminths of importance in animal and human health. Parasitology 134, Special Issue 08: 1073-1076, 2007. -(Prichard, R.K. and Roulet, A.) ABC transporters and β-tubulin in macrocyclic lactone resistance: prospects for maker development. Parasitology 134, Special Issue 08: 1123-1132, 2007. -(Bourguinat, C., Pion, S.D.S., Kamgno, J., Gardon, J., Duke, B.O.L., Boussinesq, M. and Prichard, R.K.) Genetic selection of low fertile Onchocerca volvulus by ivermectin treatment. PLoS Neg. Trop. Dis. 1(1)e72: 12-22, 2007. -(Osei-Atweneboana, M.Y., Eng, J.K.L., Boakye, D.A., Gyapong, J.O. and Prichard, R.K.) Efficacy of ivermectin against Onchocerca volvulus in Ghana. Lancet 370: 1124-1125, 2007.


20

-(Ardelli, B.F. and Prichard, R.K.) Reduced genetic variation of an Onchocerca volvulus ABC transporter gene following treatment with ivermectin. Trans. Roy. Soc. Trop. Med. Hyg. 101: 1223-1232, 2007. -(Junnila, A., Bohle, S., Prichard, R., Perepichka, I. and Spina, C. Fluorescent diethylcarbamazine analogs: Sites of accumulation in Brugia malayi. Bioconjugate Chem. 18: 1818-1823, 2007. --see also GEARY, T.G. Ribeiro, P. (Nabhan, J.F., El-Shehabi, F., Patocka, N. and Ribeiro, P.) The 26S proteasome in Schistosoma mansoni: Bioinformatics analysis, developmental expression, and RNA interference (RNAi) studies. Experimental Parasitology 117: 337-347, 2007. -(Patocka, N. and Ribeiro, P.) Characterization of a serotonin transporter in the parasitic flatworm Schistosoma mansoni: Cloning, expression and funtional analysis. Molecular & Biochemical Parasitology 154: 125-133, 2007. -(Dernovici, S., Starc, T., Dent, J.A. and Ribeiro, P.) The serotonin receptor SER-1 (5HT2ce) contributes to the regulation of locomotion in Caenorhabditis elegans. Developmental Neurobiology 67: 189-204, 2007. Scott, M.E. (Tu, T., Koski, K.G., Wykes, L.J. and Scott, M.E.) Re-feeding rapidly restores protection against Heligmosomoides bakeri (Nematoda) in protein-deficient mice. Parasitology 134: 899-909, 2007. -(Gheorghiu, C., Cable, J., Marcogliese, D.J. and Scott, M.) Effects of waterborne zinc on reproduction, survival and morphometrics of Gyrodactylus turnbulli (Monogenea) on guppies (Poecilia reticulata). International Journal for Parasitology 37: 375-381, 2007. -(Payne, L.G., Koski, K.G., Ortega-Barria, E. and Scott, M.E.) Benefit of vitamin A supplementation on Ascaris reinfection is less evident in stunted children. The Journal of Nutrition 137: 1455-1459, 2007. -(Bourgeois, A.-C., Scott, M.E., Sabally, K. and Koski, K.) Low dietary boron reduces parasite (Nematoda) survival and alters cytokine profiles but the infection modifies liver minerals in mice. The Journal of Nutrition 137: 2080-2086, 2007. -(Bourgeois, A.-C., Koski, K.G. and Scott, M.E.) Comparative sensitivity of feeding and nonfeeding stages of Heligmosomoides bakeri (Nematoda) to boron. Comparative Parasitology 74(2): 319-326, 2007. -(Tu, T., Koski, K.G. and Scott, M.E.) Mechanisms underlying reduced expulsion of a murine nematode infection during protein deficiency. Parasitology 135: 81-93, 2007


21

Spithill, T.W. (Raadsma, H.W., Kingsford, N.M., Suharyanta, Spithill, T.W. and Piedrafita, D.) Host responses during experimental infection with Fasciola gigantica or Fasciola hepatica in Merino sheep. I. Comparative immunological and plasma biochemical changes during early infection. Veterinary Parasitology 143: 275-286, 2007. -(Piedrafita, D., Estuningsih, E., Pleasance, J., Prowse, R., Raadsma, H.W., Meeusen, E.N.T. and Spithill, T.W.) Peritoneal lavage cells of Indonesian thin-tail sheep mediate antibody-dependent superoxide radical cytotoxicity in vitro against newly excysted juvenile Fasciola gigantica but not juvenile Fasciola hepatica. Infection and Immunity 75: 1954-1963, 2007. -(Yanow, S.K., Purcell, L.A., Lee, M., and Spithill, T.W.) Genomics-based drug design targets the AT-rich malaria parasite: implications for antiparasite chemotherapy. Pharmacogenomics 8(9): 1267-1272, 2007.


22

APPENDIX III CONSULTING ACTIVITIES

Between June 1, 2007 and May 31, 2008

ACADEMIC STAFF



23

Consultation Table

Number of days

Name of Faculty Member

Private Sector Consulting

Public Sector Consulting

Other

Total

G. Faubert 3 3

F. Dzierszinski 12 1 13

T. Geary 8 9 1 18

E. Georges 44 4 48

A. Jardim 12 3 15

R. Prichard 2 4 6 12

M. Scott 6 6

T. Spithill 11 11 No staff received payment for these consultation activities from the University, or any of its affiliated units.


24

APPENDIX IV

Personnel Working

at the Institute of Parasitology

-Professors

-Administrative Staff

-Technical staff

-Students


25

PERSONNEL WORKING AT THE INSTITUTE OF PARASITOLOGY 1 June 2007 - 31 May 2008 00175 Inst of Parasitology Staff for Whom This is the Major Department

Category Rank Name Full-Time Part-Time

Normal Retirement Year

Academic (Tenure Stream)

Assoc Prof

Beech/ Robin

Full Time 2027

Assist Prof

Dzierszinski/ Florence

Full Time

Prof Faubert/ Gaétan

Full Time Retired June 2008

Prof & Director

Geary/ Timothy

Full Time 2017

Assoc Prof

Georges/ Elias

Full Time 2024

Assoc Prof

Jardim/ Armando

Full Time 2028

Prof Prichard/ Roger

Full Time 2009

Assoc Prof

Ribeiro/ Paula

Full Time

Assist Prof

Salavati/ Reza

Full time 2025

Assoc Prof

Scott/ Marilyn

Full Time 2019

Prof & Director

Spithill/ Terence

Full Time Resigned Dec. 2007


26

Category

Rank Name Full Time/ Part time

Normal Retirement Date

(Non-Tenure Stream)

Research Assistant

Aurousseau/ Mark

Full Time Term contract

Research Associate

Banerjee/ Hiren


Research Assistant

Dernovici/ Serghei


Research Associate

Sabally/ Kebba


Research Assistant

Santamaria/ Cynthia


Research Assistant

Sayegh/ Laura


Faculty Lecturer

Smith/ James M.

Full Time Retired 31 Aug. 2008

Professional Associate

Wang/ Guanhua


Category

Rank Name Full Time/ Part time

Normal Retirement Date

Admin/ Support

Biotech Technician

Bangs/ Kristi

Full time Term contract

Senior Technician

Bingham/ Gordon

Full Time 2008

CFI Technician Dufresne/ Line


Technician Eng/ Jenny

Part Time Relocation assignment

Technician Keller/ Kathy

Full Time 2027

Admin Asst Mongeau/ Shirley

Full Time 2015


27

CFI Technician Sanchez/ Jaime


Receptionist/ Clerk

Solana/ Mary R.


Admin Coord

Trudeau/ Christiane

Full Time 2025

00175 Inst Parasitology Staff for Whom This is Not the Major Department

Category Rank Name Full Time or Part Time

Academic Adjunct Prof Forrester/Sean Nil salary

Adjunct Prof Marcogliese/David Nil salary

Adjunct Prof Spithill/Terence Nil salary

Assoc Member Matlashewski/ Gregory J.

Nil salary

Assoc Member Olivier/Martin Nil salary

Assoc Member Rau/ Manfred

Nil salary

Assoc Member Stevenson/ Mary

Nil salary

Assoc Member Ward/ Brian

Nil salary

00175 Inst of Parasitology Registered Postdoctoral Fellows

Name Supervisor

Dr. Catherine Bourguinat Roger Prichard

Dr. Rodrigo Miranda Roger Prichard

Dr. Joseph Nabhan Timothy Geary

Dr. Manami Nishi Florence Dzierszinski

Dr. Janelle Wright Terry Spithill


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POST-GRADUATE STUDENT ENROLMENT (September 2007) Academic Unit: Institute of Parasitology (M.Sc./Ph.D. Thesis Research Programs)

FAMILY NAME/FIRST NAME MALE/FEMALE DEGREE/YEAR CITIZENSHIP

Ammah, Mr. Adolf M. Ph.D.2 Perm. res. in Canada

Caballero-Franco, Ms. Celia F Ph.D.6 Mexico

Cyr, Mr. Normand M Ph.D.3 Canada

Darissi, Mr. Alireza M Ph.D.3 Canada

Diawara, Ms. Aissatou F M.Sc.2 France

El-Shehabi, Mr. Fouad M Ph.D.7 Perm. res. in Canada

Godoy, Mr. Pablo M M.Sc.1 Chile

Goyette, Ms. Stephanie F Ph.D.2 Canada

Halpenny, Ms. Carli F Ph.D.3 Canada

Irudayanathan, Mr. Lourde M Ph.D.2 India

Kala, Ms. Smriti F M.Sc.2 India

Laberge, Mr. Rémi M Ph.D.5 Canada

Leimanis, Ms. Mara F Ph.D.6 Canada

Leroux, Mr. Louis-Philippe M M.Sc.1 Canada

Moreno, Mr. Yovany M Ph.D.3 Perm. res. in Canada

Moshiri, Mr. Houtan M M.Sc.2 Perm. res. in Canada

Odiere, Mr. Maurice M. Ph.D.3 Kenya

Osei-Atweneboana, Mr. Mike M Ph.D.6 Perm. res. in Canada

Patocka, Mr. Nicholas M Ph.D.3 Canada

Pilar, Ms. Ana Victoria F Ph.D.7 Philippines

Rao, Mr. Vijay M Ph.D.2 Perm res. in Canada

Rauba, Ms. Andrea F M.Sc.1 Canada

Rioux, Ms. Marie-Claire F Ph.D.4 Canada

Shateri, Mr. Hamed M Ph.D.2 Iran

Solomon, Mr. Jonathan M M.Sc.2 Canada

Strasser, Ms. Rona F Ph.D.2 Canada

Taman, Ms. Amira F Ph.D.3 Egypt

Total number of thesis students: 27


29

POST-GRADUATE STUDENT ENROLMENT (September 2007) Academic Unit: Parasitology/ Biotechnology Graduate Programs

Family Name/First Name Male/F

emale (M/F)

Degree/Year

Citizenship (indicate if permanent

resident) Adams, Julia F MSc.A.1 USA Agarwal, Khushboo F MSc.A.1 India Ait Tihyaty, Maria F Msc.A.1 Canada Aurousseau, Mark M MSc.A.2 Canada Boulos, Toufic M MSc.A.1 Canada Cianciarelli, Gaetano M MSc.A.1 Canada Deng, XianDing M MSc.A.1 China/Permanent resident Frank, Alexander M MSc.A.1 Canada Gao, Tao M Grad. Cert. China/Permanent Resident He, Wei F MSc.A.1 Canada Hovhannesyan, Kristine F Grad. Cert. Armenia/Permanent Resident Islam, Rafiqul M MSc.A.2 Pakistan/Permanent Resident Kathiresan, Meena F MSc.A.1 Canada Katta, Amita F Grad. Cert. Canada Lan,Lan F MSc.A.1 Canada Li, Jessie F MSc.A.1 Canada Li, Qi M MSc.A.1 China Lobach, Alexandra F MSc.A.2 Canada Mabanga, Tsoarello F MSc.A.1 Zimbabwe/Permanent Resident Mao, Yuan F MSc.A.1 Canada Merritt, Duane M MSc.A.2 Trinidad & Tobago Mogra, Shabana F MSc.A.1 Canada Olsen, Jonathan M MSc.A.2 Canada Paul, Arghya M MSc.A.2 India Pollock, Remy Angela F MSc.A.2 Canada Salek, Cyrus M MSc.A.1 Canada Sayegh, Laura F MSc.A.2 Canada Sowmithran, Arthi F MSc.A.1 India Takkar, Rashi F MSc.A.1 Canada Tasneem, Maaiedah F MSc.A.1 Pakistan/Permanent Resident Thandapani, Palaniraja M MSc.A.1 India Uppal, Ambica F MSc.A.2 India Vemuri, Madhavi Latha F MSc.A.1 India/Permanent Resident Wong, Isidro M MSc.A.1 Canada Yin, Shou-Yun F MSc.A.1 Canada Zhang, Yu F MSc.A.2 China


30

APPENDIX V

Activity Reports of the Academic Staff



31

ACTIVITY REPORT FOR 2007-2008

Name: Robin N. Beech Date: July 5, 2008 A. Research and Scholarly Activities 1a. Publications in Refereed Journals Gilleard JS, Beech RN. 2007. Population genetics of anthelmintic resistance in parasitic

nematodes. Parasitology 134(Pt 8):1133-47. Jia X, Ebine N, Demonty I, Wang Y, Beech R, Muise V, Fortin MG, Jones PJ. 2007.

Hypocholesterolaemic effects of plant sterol analogues are independent of ABCG5 and ABCG8 transporter expressions in hamsters. British Journal of Nutrition 98(3):550-555.

Jain D, Ebine N, Jia X, Kassis A, Marinangeli C, Fortin M, Beech R, Hicks KB, Moreau RA, Kubow S, Jones P.J.H. 2008. Corn fiber oil and sitostanol decrease cholesterol absorption independently of intestinal sterol transporters in hamsters. Journal of Nutrition and Biochemistry 19: 229-236.

2. Conference Presentations and Invited Lectures Beech R, Redman E, Mungall K, Berriman M, Gilleard J. 2007. The nature of sequence

variation in the parasite Haemonchus contortus. Canadian Society of Zoologists. Montreal, Canada. May 21-25.

Beech R. 2007. Parasitic nematode genomes. Consortium on anthelmintic resistance and SNPs. Ghent, Belgium. August 18.

Beech R. 2007. Ligand-gated Ion-channel annotation in Haemonchus contortus. Consortium on anthelmintic resistance and SNPs. Ghent, Belgium. August 18.

Beech R. 2007. Annotating channels in Haemonchus contortus: cherry picking in a construction zone. Institute of Parasitology, Seminar Series. Institute of Parasitology, McGill University. (Invited). September 21.

5. Grants held 2005 – 2006 NSERC Research, $28,000, Beech RN Ayerst Canada, $120,000, Prichard RK, Beech RN, Ribeiro P, Georges E, Scott ME

(Responsible for $40,000) FQRNT, Government of Quebec. “Centre for Host-Parasite Interactions”.

Regroupements Strategiques Centre grant. Spithill along with 30 others from across Quebec. $345,800 pa. for 2005-2006.


32

Center for Host-Parasite Interactions. New Initiatives grant. Beech RN, Dent JA,

Prichard RK and Geary TG $30,500 (Responsible for $30,500) 2006 – 2007 FQRNT, Government of Quebec. “Centre for Host-Parasite Interactions”.



Prichard RK and Geary TG $30,500 (Responsible for $30,500) 2007 - 2008 FQRNT, Government of Quebec. “Centre for Host-Parasite Interactions”.



Prichard RK and Geary TG $28,500 (Responsible for $28,500) 7. Refereeing and Editorial Work Beech R, editor. 2007. 46th Annual Meeting of the Canadian Society of Parasitologists.

Montreal. Canadian Society of Parasitologists Bullitin. 46 (2): 201pp. Ad hoc reviewer for International Journal of Parasitology, Journal for Parasitology, Veterinary Parasitology Molecular and Biochemical Parasitology 8. Other Scientific Activities Member of the local organizing committee of the 46th Annual meeting of the Canadian

Society of Zoologists. Initiated and edited the online website for the Consortium on Anthelmintic Resistance

and SNPs Wrote an article for the website on the use of candidate gene studies for understanding

anthelmintic resistance.


33

B. Teaching and Graduate Supervision 1. Courses taught AEBI 202 Cellular Biology (approximately 90 students) Winter 2007 This course is coordinated by Prof Ribeiro. I was responsible for 1/3 of the lectures. Unfortunately, for reasons beyond my control I was never added to the online evaluation system and therefore have no record of my performance in teaching this class. Although I have no access to the results I believe the student comments for the course were mainly complimentary about my performance. BTEC 501 Bioinformatics (24 students) Winter 2007

a. Q10 4.7 b. Q21 4.7

BTEC 501 Bioinformatics (28 students) Fall 2007

c. Q10 4.2 d. Q21 3.9

2. Supervision of undergraduate projects John Lee. Summer student: cloning cDNA of the ligand-gated ion-channels from Haemonchus contortus Jim Geary. Summer student: cloning and bioinformatic analysis of the ligand-gated ion-channel from Haemonchus contortus. C. Administrative Activities 1. Committees PhD Thesis Examination Committee, External Member for Mr Scott Harding, Nutrition. PhD Comprehensive Examination Committee for Ms Gitanjali Ayra, Natural Resource Science PhD Supervisory Committee Member, Hamed Shateri, Institute of Parasitology PhD Supervisory Committee Member, Vanessa Dufour, Institute of Parasitology MSc Supervisory Committee Member, Pablo Godoy, Institute of Parasitology Macdonald Campus Environmental Committee, Member 4. Administrative Appointments Graduate Program Director for the Institute of Parasitology Website Administrator for the Institute of Parasitology E. Consulting None


34

ACTIVITY REPORT 2007 – 2008 Name: Florence S. Dzierszinski

[appointment Dec 1st, 2006] Date: July, 2008 A. RESEARCH AND SCHOLARLY ACTIVITY [Jan 1, 2007 – Dec 31, 2007] 1. Publications

a) Publications in REFEREED Journals

* Dzierszinski F, Pepper M, Stumhofer JS, LaRosa DF, Wilson EH, Turka LA, Halonen SK, Hunter CA, Roos DS. Presentation of Toxoplasma gondii antigens via the endogenous major histocompatibility complex class I pathway in nonprofessional and professional antigen-presenting cells. Infection & Immunity. 2007 (November); 75(11): 5200-5209. IF 2007 = 3.996. Note: this article was chosen as the cover image of this IAI issue.

* Menard LC, Minns LA, Darche S, Mielcarz DW, Foureau DM, Roos D, Dzierszinski F, Kasper LH, Buzoni-Gatel D. B cells amplify IFN-gamma production by T cells via a TNF-alpha-mediated mechanism. Journal of Immunology. 2007 (October); 179(7): 4857-4866. IF 2007 = 6.068

* Sarry JE, Chen S, Collum RP, Liang S, Peng M, Lang A, Naumann B, Dzierszinski F, Yuan CX, Hippler M, Rea PA. Analysis of the vacuolar luminal proteome of Saccharomyces cerevisiae. FEBS J. 2007 (August); 274(16): 4287-4305. IF 2007 = 3.396

b) Publications in REFEREED Conference Proceedings

* Dzierszinski, F. 46th annual meeting of the Canadian Society of Zoologists, Parasitology Symposium. McGill University, Montréal, May 25th, 2007. “Toxoplasma gondii: some secrets of success”. * Nishi M., Harb O., Chen Z.Q., Dzierszinski F., and Roos D.S. 9th International Toxoplasma Meeting. Chico, MT, USA, June 2007. “Cell-cycle Regulation of Organelle Biogenesis and Vesicle-mediated Apicoplast Protein Trafficking in Toxoplasma gondii”. * Bahl A., Davis P.H., Dzierszinski F., Jagalur M.N., Kulp D.C., and Roos D.S. 9th International Toxoplasma Meeting. Chico, MT, USA, June 2007. “Design and implementation of multifunctional arrays for whole genome expression profiling, genotyping, and other applications in Toxoplasma gondii”.


35

* Beiting D., Dzierszinski F., Blackburn S., Wherry E.J., and Roos D.S. 9th International Toxoplasma Meeting. Chico, MT, USA, June 2007. “CD8+ T cell memory and mucosal immunity to Toxoplasma gondii” c) Other Publications

Published Chapter in Refereed Book

* Dzierszinski F & Knoll LJ. 2007. Chapter 17. Biology of bradyzoites. In: Toxoplasma: Molecular and Cellular Biology. Part 4. Growth, Development and Metabolism, Eds: Soldati D (University of Geneva, Switzerland) & Ajioka J (University of Cambridge, UK), pp 303-319. Horizon Bioscience. ISBN: 978-1-904933-34-2

Cover artwork

* Infection and Immunity, November 2007, Volume 75, Issue 11. Cover photograph. Dzierszinski F: “MHCI-restricted antigen presentation by IFN-γ/TNF-α-activated primary astrocytes infected with transgenic T. gondii parasites secreting the model antigen ovalbumin (OVA) into the parasitophorous vacuole”. 2. Conference presentations and invited lectures

Invited Lectures

* Dzierszinski, F. Dean’s Donor Reception “Health, Nutrition and Climate Change”. McGill University, FAES, April 19th, 2007. “Studying Toxoplasma gondii Pathogenesis to Understand Immunity to Intracellular Pathogens and Progress towards Rational Vaccine Design”. * Dzierszinski, F. 46th annual meeting of the Canadian Society of Zoologists, Parasitology Symposium. McGill University, Montréal, May 25th, 2007. “Toxoplasma gondii: some secrets of success”. * Dzierszinski, F. 6th annual “Food for Thought” Public Lecture Series “Challenges for the 21st century”. McGill University, FAES, September 11th, 2007. “Biosecurity & Biosafety: When Mother Nature is Grumpy”. * Dzierszinski, F. Seminar Series of the Département de Pathologie et Microbiologie. Université de Montréal, December 14th, 2007. “From acute infection to persistence: Interactions between the protozoan parasite Toxoplasma gondii and the antigen presentation pathways in the host cells”. Conference Presentations

* Nishi M., Harb O., Chen Z.Q., Dzierszinski F., and Roos D.S. 9th International Toxoplasma Meeting. Chico, MT, USA, June 2007.


36

“Cell-cycle Regulation of Organelle Biogenesis and Vesicle-mediated Apicoplast Protein Trafficking in Toxoplasma gondii”. * Bahl A., Davis P.H., Dzierszinski F., Jagalur M.N., Kulp D.C., and Roos D.S. 9th International Toxoplasma Meeting. Chico, MT, USA, June 2007. “Design and implementation of multifunctional arrays for whole genome expression profiling, genotyping, and other applications in Toxoplasma gondii”. * Beiting D., Dzierszinski F., Blackburn S., Wherry E.J., and Roos D.S. 9th International Toxoplasma Meeting. Chico, MT, USA, June 2007. “CD8+ T cell memory and mucosal immunity to Toxoplasma gondii” 3. Supervision of and collaboration with postdoctoral fellows and other

visitors

- Dr Manami Nishi, supervision (June 2007 – present) - Dr Cristina Georghiu, supervision (Jan 2007 – May 2007) - Dr Daniel Beiting, supervision (Jan 2005 – June 2007, University of Pennsylvania, Dr DS Roos laboratory) 4. Organization and participation in advanced seminars (beyond regular

teaching assignments)

- Coordinator of the Institute of Parasitology Graduate Seminar series. Fall semester 2007. Organization/Advertisement of the following seminars and accommodation of the guest speakers:

External invited guest speakers:

1. Dr. Jeff Williams, HaloSource, “New water treatment technologies: making water safer for salmon, swimmers, and slum dwellers”, September 26th, 2007.

2. Dr. Ana Rodriguez, NYU School of Medicine, Medical Parasitology, “Plasmodium infection and immune response: from the liver to the blood”, September 28th, 2007.

3. Dr. David Waltner-Toews, Department of Population Medicine, Univ. of Guelph, "Between Parasites and Planets: Science in the Muddled Middle", October 5th, 2007.

4. Dr. Gary Ward, Department of Microbiology and Molecular Genetics, Univ. of Vermont, “A small molecule approach to studying host cell invasion by Toxoplasma gondii”, October 19th, 2007.

5. Dr.Stephen Michnick, Département de Biochimie, Univ. de Montréal, “The dynamics of protein interaction networks in living cells”, October 26th, 2007.


37

6. Dr. Denis Gaucher, Département de Microbiologie et Immunologie, Univ. de Montréal, “Correlates of protection: the immune response to yellow fever vaccination”, November 2nd, 2007.

7. Dr. Lea Berrang Ford, Department of Geography, McGill Univ., “Spatial and temporal analysis of infectious disease: a case study of sleeping sickness in Uganda”, November 9th, 2007.

8. Dr. Rebecca Guy, Public Health Agency of Canada, “Molecular characterization of parasitic protozoa in aquatic environments”, November 23rd, 2007.

9. Dr. Michael Reed, McGill University Health Centre, "Mycobacterium tuberculosis – does pathogenic diversity exist?", November 30th, 2007.

Internal invited guest speakers:

10. Jaime Sanchez-Dardon, Flow Cytometry Core Facility, Institute of Parasitology, “Flow cytometry for each and everyone: Presentation of a variety of quantitative and qualitative applications in engineering and biological sciences”, September 7th, 2007.

11. Dr Robin Beech, Institute of Parasitology, “Annotating channels in Haemonchus contortus: Cherry Picking in a Construction Zone”, September 21st, 2007.

Institute of Parasitology postdoctoral fellows and students:

12. Vijay Rao (PhD), “Haemonchus contortus putative ligand-gated chloride channel: Life stages expression and possible role in macrocyclic lactone resistance”, September 14th, 2007.

13. Amira Taman (PhD), “Properties of neurotransmitters in Schistosoma mansoni”, September 14th, 2007.

14. Dr. Manami Nishi (PDF), “Mechanisms of antigen presentation and host cell subversion during acute and chronic infection by Toxoplasma gondii”, October 12th, 2007.

15. Carli Halpenny (PhD), “Using an ecosystem approach to assess the impact of Panamanian conditional transfer programs on gastrointestinal parasite infections”, November 16th, 2007. 5. Grants held - 3-yr. period: 2005-06; 2006-07; 2007-08

Awarded

1. Natural Sciences and Engineering Research Council of Canada (NSERC), Individual Discovery Grants Program April 2007-March 2012, $35,059.00 per year.

2. Natural Sciences and Engineering Research Council of Canada (NSERC), Research Tools and Instruments Program (RTI – category 1) October 2006 competition, $30,583.00


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3. Canada Research Chair (CRC Tier 2 in Parasite Pathogenesis) April 2007-March 2012, $100,000.00 per year, renewable once.

4. Canada Foundation for Innovation (CFI). April 2007, $375,000.00

5. Centre for Host-Parasite Interactions (CHPI) / Le Fonds québécois de la recherche sur la nature et les technologies (FQRNT); New Initiatives Program Joint grant Dzierszinski F (principal investigator, McGill) /Jardim A (McGill) / Desjardins M (Université de Montréal) March 2007: awarded, $28,468.00 for 1 year. March 2008: renewed, $28,468.00 for 1 year.

6. March of Dimes Basil O’Connor Starter Scholar Research Award 2008 competition: awarded. $150,000.00, 2 years. Pending / Applied for:

7. Gates Foundation, Grand Challenges Explorations May 2008 competition. $100,000.00

8. NSERC CREATE: “Canadian Preparedness to Combat Emerging Pathogens” Prichard, Roger (Principal Investigator); Barrang Ford, L; Dzierszinski, F; Egeland, G; Geary, TG; Jardim, A; Johns, T; Ribeiro, PA; Salavati, R; Scott, ME; Tufenkji, N. Unsuccessful applications:

1. Canadian Institutes of Health Research (CIHR); Operating Grant Program. March 2007 and September 2007 competitions

2. MAPAQ (Ministère de l’Agriculture, des Pêcheries et de l’Alimentation du Québec) / FPPQ (Fédération des Producteurs de Porcs du Québec); Program “Soutien à l’innovation en agroalimentaire”. November 2006 competition.

3. NSERC, Research Tools and Instruments Program (RTI – category 1); October 2007 competition. Fellowships & Scholarships Awarded to Lab Members

1. Canada summer Jobs 2007 to Allison Nicholls, U2, UVic co-op program, $1.400.00

2. CIHR doctoral research award to Stephanie Goyette, PhD Parasitology Graduate Program, McGill, $21,000 (plus $1,000 research allowance) per year for 3 years.

3. Lynden Laird Scholarship for studies in Parasitology to Louis-Philippe Leroux, MSc thesis Parasitology Graduate Program, McGill. $14,000.00 per year for 3 years.

4. FQRNT v2 merit postdoctoral fellowship to Dr Manami Nishi, $35,000.00, 1 year.


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5. NSERC USRA, summer 2008, to Geneviève Dallaire (Microbiology, U2), $4,500.00

6. Canada Summer Jobs 2008 (student to be named), $1,636.25 6. Honors and Awards received

* Canada Research Chair tier 2 in Parasite Pathogenesis (April 2007)

* Basil O’Connor Starter Scholar Research Award, March of Dimes Foundation (December 2007) 7. Refereeing and editorial work

* Scientific journals: - Immunology - Infection and Immunity - International Journal for Parasitology

* Fellowships, Grants, Prizes: - Guava Technologies prize committee member for the best presentations, 9th International Congress on Toxoplasmosis, Chico, MT, USA (July 2007)

- Wellcome Trust, Career Re-Entry Fellowship Committee, External reviewer (2007) 8. Other scientific activities

* Memberships: - Centre for Host-Parasite Interactions, McGill University and FQRNT

- Canadian Society for Immunology * Knowledge translation / dissemination activities - “L'agresseur des litières”, Agence Science Presse, Isabelle Burgun, June 8th 2007.

- “In the world of parasites”, McGill Reporter, Nadine Fortin, April 19th 2007.

- CIHR Synapse mentor (2007-) B. TEACHING AND GRADUATE STUDENT SUPERVISION (January 1, 2007 - May 31, 2008, i.e. over 18 months, as per agreement with Profs Geary and Madramootoo).

1. Courses taught and evidence of effectiveness:

COMMENT: scores are provided according to Q10 = “Overall, the instructor is a good teacher”, and Q21 = “Overall, this is a good course”


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WINTER 2007 SEMESTER

1. PARA 515 (Health hazards of water-borne biological agents and chemicals) Coordinator: Dr. Tim Geary One lecture: a. “Toxoplasma gondii as water-borne biological hazard”. No evaluation available (I was not registered as instructor in Mercury at the time). 2. PARA 635B (Cell Biology and Infection) Coordinator: Dr. Roger Prichard Three lectures: a. “Antigenic variation in bacteria and protozoa” b. “Molecular mechanisms of host cell hijacking by intracellular pathogens” c. “Biology of active host cell invasion by Apicomplexan parasites” Mean Q10 = 4.4; Mean Q21 = 4.2 Response rate: 71.4% FALL 2007 SEMESTER

1. PARA 438 (Immunology) Coordinator: Dr. Florence Dzierszinski Dzierszinski, F.: 26 lectures Faubert, GM.: 13 lectures Grading shared by the two instructors Mean Q10 = 3.8; Mean Q21 = 3.9 Response rate: 44%

*Note: this course was part of the pilot experiment at FAES with the Student Response System (clickers) to enhance student engagement. 2. MIMM 414 (Advanced Immunology) Coordinator: Dr. Sylvie Fournier Two lectures: a,b. “subversion of the host immune responses by the intracellular parasite Toxoplasma

gondii”. Mean Q10 = 4.1; Mean Q21 = 4.3 Response rate: 25% 3. PARA 606, Parasitology Seminar PARA 607, Parasitology Research Seminar PARA 710, Parasitology Ph.D. Seminar 1

PARA 711, Parasitology Ph.D. Seminar 2 Coordinator: Dr. Florence Dzierszinski No evaluation available (not conducted)


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WINTER 2008 SEMESTER

1. PARA 515 (Health hazards of water-borne biological agents and chemicals) Coordinator: Dr. Tim Geary One lecture: a. “Toxoplasma gondii as water-borne biological hazard”. Mean Q10 = 3.7; Mean Q21 = 4.7 Response rate: 66.7% 2. PARA 635B (Cell Biology and Infection) Co-coordinators: Drs. Roger Prichard & Florence Dzierszinski Two lectures: a. “Antigenic variation in bacteria and protozoa” b. “Molecular mechanisms of host cell hijacking by intracellular pathogens”

*Note: I developed a lab component, in order for graduate students to better grasp the content of the papers that were analyzed in this course Lab1 : transfection, Lab2: confocal microscopy

Grading shared by the two instructors Mean Q10 = 4.7; Mean Q21 = 4.1 Response rate: 77.8% 3. PARA 606, Parasitology Seminar PARA 607, Parasitology Research Seminar PARA 710, Parasitology Ph.D. Seminar 1 PARA 711, Parasitology Ph.D. Seminar 2 Coordinator: Dr. Florence Dzierszinski; No evaluation available (not conducted) 2. Supervision of undergraduate projects

a. Allison Nicholls (May 2007-August 2007), UVic co-op program. Support: Canada Summer Jobs and NSERC (Discovery grant to FD).

b. Melissa Kanter (Jan 2008-April 2008), McGill, FAES, U3 Microbiology major. Support: NSERC (Discovery grant to FD).

c. Geneviève Dallaire (Jan 2008 – December 2008); McGill, FAES, U2-3 Microbiology major. MICR481 (Microbiology Projects; Winter 08 & Fall 08) and Summer project. Support: NSERC USRA (Summer 2008) and NSERC (Discovery grant to FD).

d. To be named (Summer 2008). Support: Canada Summer Jobs and NSERC (Discovery grant to FD).


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3. Graduate student currently being supervised: a. Adolph A Ammah (May 2007-September 2007), PhD Parasitology Graduate Program, McGill. Support: NSERC DG grant, $16,000 per year (stipend)

b. Louis-Philippe Leroux (2007-present, MSc thesis Parasitology Graduate Program, McGill - Interactions between T. gondii and dendritic cells (cell molecular biology, microscopy). Support: Lynden Laird Scholarship for studies in Parasitology. $14,000.00 per year.

c. Stéphanie Goyette (2007-present), PhD Parasitology Graduate Program, McGill – Interactions between T. gondii and CD8 T cells in immune privileged areas. Co-supervision with Dr Brian Ward (McGill). Support: CIHR doctoral research award, $21,000 (plus $1,000 research allowance) per year.

d. Madhavi Latha Vemuri (June 2008-present), MSc (Applied) in Biotechnology, McGill. C. ADMINISTRATIVE AND OTHER ACADEMIC ACTIVITIES (January 1, 2007 - May 31, 2008, i.e. over 18 months, as per agreement with Profs Geary and Madramootoo).

1. Committees - Department/Faculty/University

a. Curriculum Graduate Studies committee, Institute of Parasitology. Member (January 2007-present). b. Scholarships committee, Institute of Parasitology, McGill University. Member (January 2008-present). Including student selection for: Tomlinson doctoral fellowship, Max E. Binz fellowship, Max Stern fellowship, Principal’s Graduate Fellowships c. Faculty search committee 2008, Institute of Parasitology, McGill University. Member (Junior position, replacement for Prof. G. Faubert) d. Macdonald campus library committee, FAES, McGill University. Member (May 2007-present). e. Small Animal Research Unit (SARU) Users Committee, FAES, McGill University. Chair (May 2008-present). Redaction of the document that initiated the formation of this committee. - Thesis Examination committees:

f. Yovany Moreno, PhD candidate. Comprehensive examination. “Proteins secreted by Brugia malayi”.


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Supervisor: Prof. T. Geary, Institute of Parasitology. Internal reviewer. March 2007. g. Karen Yam, PhD candidate. Comprehensive examination. “Lactococcus lactis adjuvant effects and its usage as live vaccines against leishmaniasis”. Supervisor: Prof. B. Cousineau, Department of Microbiology and Immunology External examiner. April 24th, 2007. h. Catherine Ivory, PhD thesis. Supervisor: Prof. C. Chadee, Institute of Parasitology. Internal examiner. i. Aws Abdhul-Wahid, PhD thesis. “Development and evaluation of a CWP2-encoding Giardia transmission-blocking DNA vaccine”. Supervisor: Prof. G. Faubert, Institute of Parasitology Internal reviewer. October 10th, 2007. j. Lisa Purcell, PhD thesis. “Genetic and biochemical strategies to block the transmission cycle of the malaria parasite”. Supervisor: Prof. T. Spithill, Institute of Parasitology. Internal reviewer. November 15th, 2007. k. José Estrada, PhD candidate. Comprehensive examination. “Mechanisms of demyelination and axonal damage in an animal model of CD8+ T cell-meditated neurogical disease”. Supervisor: Prof. S. Fournier, Department of Microbiology & Immunology. External examiner. March 31st, 2008. l. José Estrada, PhD candidate. Graduate Committee. Supervisor: Prof. S. Fournier, Department of Microbiology & Immunology. Committee member (replacing Dr. J. Desbarats). April 29th, 2008. m. Xiaoliang Wang, MSc thesis. “DNA methylation of two milk protein genes in lactating and non-lactating bovine mammary gland tissues”. Supervisor: Prof. X. Zhao, Department of Animal Science. External reviewer. May 2008. n. Tao Tu, PhD thesis. "Interactions among dietary Protein Intake, Immunopathology, and Heligmosomoides bakeri (Nematode) Infection in Mice”. Supervisors: Profs. M.E. Scott, Institute of Parasitology and K. Koski, School of Dietetics and Human Nutrition. Internal examiner. June 20th, 2008. o. Philippe Dufresne, PhD thesis. “Involvement of poly (A)-binding and heat shock 70 kDa proteins in Turnip mosaic virus infection”. Supervisor: Prof. M. Fortin, Department of Plant Science. External examiner. June 25th, 2008.


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2. Academic advising

* MScA Biotech students (September 2007 - December 2008): - Shou-Yun Yin - Julia Adams 3. External activities * Dean’s Donor Reception “Health, Nutrition and Climate Change”, FAES, McGill University, April 2007. Speaker.

* Local organization committee 46th annual meeting of the Canadian Society of Zoologists, May 2007, McGill University, QC, Canada. Organized registration of participants and fee collection.

* Dean’s Donor Reception, FAES, McGill University, April 2008. Representing the Institute of Parasitology.

* “Academia Day”, McGill Career Centre 's Graduate Career Week, March 10th 2008. 5. Other professional activities

* Administrator microscopy core facility, Institute of Parasitology, McGill. December 2006-present. Involves: student training, establishment/writing of guidelines, microscope alignments and adjustments, warranties and service contracts, dealing with users.

* Administrator flow cytometry core facility, Institute of Parasitology, McGill. December 2006-present. Involves: Mr Jaime Sanchez (Dec 2006-March 2008), training of Ms Kristi Bangs (April 2008-present), dealing with technical issues, financial aspects, student training, establishment/writing of guidelines, FAES equipment pool dossier, warranties and service contracts, dealing with internal and external users for access and experiment protocols, EHS re:laser safety. D. INTERNATIONAL ACTIVITIES (Jan 1, 2007 - May 31, 2008).

1. N-Glycosylation in Apicomplexan parasites a. Name of Project Director: Stanislas Tomavo, UMR CNRS 8576

b. Nature of the activity: Research c. Source and level of funding: N/A d. Partner country: France

e. Project duration: Undetermined 2. Analysis of genome-wide expression in Toxoplasma gondii a. Name of Project Director: David S. Roos, University of Pennsylvania

b. Nature of the activity: Research


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c. Source and level of funding: N/A d. Partner country: USA

e. Project duration: Undetermined 3. Toxoplasma gondii transgenic parasites to study cellular immunity

a. Name of Project Directors: F. Dzierszinski, McGill University and C.A. Hunter, University of Pennsylvania

b. Nature of the activity: Research c. Source and level of funding: N/A d. Partner country: USA

e. Project duration: Undetermined 4. Toxoplasma gondii dense granule proteins

a. Name of Project Directors: F. Dzierszinski, McGill University and Marie-France Cesbron-Delauw, Université de Grenoble, CNRS

b. Nature of the activity: Research c. Source and level of funding: N/A d. Partner country: France

e. Project duration: Undetermined

E. CONSULTING

* “Mystery Hunters”, Discovery Kids channel, 1 day.

* PharmAthene, St. Telephore, QC. Contact: Hernan Baldassarre, DVM, 1 day/month.


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ACTIVITY REPORT FOR 2007-2008 Name: Gaétan M. Faubert Date: June 19, 2008 A. RESEARCH AND SCHOLARLY ACTIVITIES 1. a) Publications in Refereed Journals Aws Abdul-Wahid and Gaétan Faubert, 2007. Mucosal delivery of a transmission blocking vaccine encoding Giardia lamblia CWP2 by Salmonella typhimurium bactofection vehicle. Vaccine, 25: 8372-8383. Aws Abdul-Wahid and Gaétan Faubert, 2008. Characterization of the local immune response to cyst antigens during the acute and elimination phases of primary murine giardiasis. International Journal for Parasitology 38: 691-703 Lee, P. and G.M. Faubert. 2008. Comparison of the local immune response against Giardia lamblia cyst wall protein 2 induced by recombinant Lactococcus lactis and Streptococcus gordinii. Accepted for publication in Vaccine June 2008. c) Lecture Notes Lecture notes were prepared for the courses listed under the Section “Teaching”. (6 series of notes – one for each course). 5. Grants Held NSERC $26,500/year for 1 year NSF $334,000 US for 3 years Articnet Inc. $125,000/year for 3 years 7. Refereering and Editorial Work Journal of Parasitology………………………3 manuscripts Infection and Immunity…………………… 2 manuscripts Journal of Infectious Diseases……………… 2 manuscripts International Journal for Parasitology…….…1 manuscripts NSERC………………………………………1 grant proposal 8. Other Scientific Activities a) Co-Chair of the annual FQRNT meeting held at UQAM, June 12 and 13, 2008. b) Chair of the local organizing committee (LOC) for the meeting held at McGill in May 2007 c) President of the Parasitology Section of CSZ d) Invited instructor at the annual meeting held by McGill teaching office. I did demonstration for using Turning point technology for teaching.


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B. TEACHING AND GRADUATE STUDENT SUPERVISION 1. Courses Taught: Course Number of Hours* Water, Health & Sanitation PARA 515 3 hours of lectures Parasitology MIMM 413 18 hours of lectures + 4 hours lab Immunology PARA 438 36 hours of lectures Cellular & Applied Immunology PHGY 552 6 hours of lectures Topics in Applied Immunology PHGY 531 4 hours of lectures Immunology Laboratory MIMM 528 10 hours of lectures *Not included in the above hours for teaching: 1. time for reading term papers 2. time spent on tutorials 3. time answering e-mail messages from students asking questions about the lecture of the day 4. time to prepare the lectures 5. time to prepare and to correct the exam Evidence of Effectiveness: Course Number of Students Overall evaluation Water, Health & Sanitation PARA 515 12 4.2 Parasitology MIMM 413 105 4.0 Immunology PARA 438 35 4.7 Cellular & Applied Immunology PHGY 552 25 4.4 Topics in Applied Immunology PHGY 531 20 4.3 Immunology Laboratory MIMM 528 95 4.1 3. a) Graduate Students who have Graduated in 2008: Aws Abdul-Wahid. C. ADMINISTRATIVE ACTIVITIES a) Institute of Parasitology Building Director includes several activities related to the Building Member, Safety Committee Responsible for library & photocopier Chair, Equipment Committee Supervision of the renovation of Lab A-215 & B2.1 b) Member of the tenure committee for the Faculty of Music. c) Faculty of Agricultural and Environmental Sciences

Recruitment of students for the Biotech Certificate on the downtown campus


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Writing letters (11) of reference on behalf of undergraduate and graduate students

d) Provincial and National Chair of the Parasitology Section of the Canadian Society of Zoologists, May

2005-2008 Chairman of the LOC Annual Meeting of the Canadian Society of Zoologists

for 2007 e) Affiliations: Professor, Institute of Parasitology Associate Member, Brace Centre for Water Management Associate Member, Department of Microbiology and Immunology Associate Member, Department of Internal Medicine, Montreal General

Hospital Associate Member, Department of Physiology, Faculty of Medicine

E. CONSULTING (June 1, 2006 to May 31, 2007) Name: Gaétan Faubert Signature: G. M. Faubert

Private Sector (detailed breakdown)

Public Sector (detailed breakdown)

Other (detailed breakdown)

None Science Fair evaluation, at High Schools Responding to Government, Municipalities and the general public regarding issues related to water polluted by parasites,

None

Total : 0 Total: 3 Total:0


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ACTIVITY REPORT FOR 2007-2008 Name: Timothy G. Geary Date: August 4, 2008 A. RESEARCH AND SCHOLARLY ACTIVITY 1. Publications in calendar year 2007

a) Refereed Journals:

Mackenzie, C., Geary, T., Prichard, R., Boussinesq, M. Where next with Loa loa encephalopathy? - Data are badly needed! Trends in Parasitology 23:237-238, 2007. Woods, D.J., Lauret, C., Geary, T.G. Anthelmintic discovery and development in the animal health industry. Expert Opinion on Drug Discovery 2(S1): 1-9, 2007. Omar, H.H., Humphries, J.E., Larsen, M.J., Kubiak, T.M., Geary, T.G., Maule, A.G., Kimber, M.J., Day, T.A. Identification of a platyhelminth neuropeptide receptor. International Journal for Parasitology 37:725-733, 2007. Prichard, R.K., Samson-Himmelstjerna, G. von, Blackhall, W.J., Geary, T.G. Forward: Towards markers for anthelmintic resistance in helminths of importance in animal and human health. Parasitology 134:1073-1076, 2007. 2. Conference Presentations and Invited Lectures: “Nematode neuropeptidergic systems as targets for antiparasitic drug discovery”, TG Geary, Invited seminar, Department of Biochemistry, McGill University, Montreal, February 2007 “Nematode FMRFamide-like peptides: the same sequences in different places” A Mousley, M Johnston, I Miskelly, NJ Marks, TG Geary & AG Maule, British Society for Parasitology, Belfast, April 2007 “Identification and analysis of biomarkers associated with infection with Sarcocystis neurona”, AE Schwab, SP Ellison & TG Geary, Canadian Society of Zoologists, Montreal, May 2007


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“Antiparasitic drug discovery through high-throughput screening: when will it succeed?” TG Geary, Invited symposium speaker, North American Parasitology Conference, Merida, Yucatan, Mexico, June 2007 “Better living through chemistry: new drugs must be found”, TG Geary, Invited symposium speaker, World Association for the Advancement of Veterinary Parasitology Conference, Ghent, Belgium, August 2007 “The unsolved problems of parasites: So many species, so little time”, TG Geary, McGill Vogel Lecture, Montreal, November 2007 “Diethylcarbamazine, nicotinic agonists and triclabendazole: Pharmacology and resistance”, TG Geary, invited lecture, World Bank/WHO Conference on "Monitoring of Drug Efficacy in Large Scale Treatment Programmes for Human Helminthiases", Washington DC, November 2007. “Roles of secreted products in defining the host-parasite relationship”, TG Geary, IDEXX, Inc., invited lecture, Portland, ME, November 2007 3. Supervision of postdoctoral fellow and research associate, 2007-08: Dr. Anne Schwab Dr. Joseph Nabhan 5. Grants held - 3-yr. period: 2005-06; 2006-07; 2007-08:

Tier 1 Canada Research Chair in Parasite Biotechnology, 2005-2012, $50,000 (research support)

CFI, 2005-2007, $375,000 NSERC, 2006-2011, $42,556 FQRNT New Initiatives, Geary (P.I.), Spithill, Fecteau, Villeneuve, 2005-2007,

$60,000 total FQRNT New Initiatives, Spithill (P.I.), Geary, Ward, Ndao, 2005-2007, $60,000 FQRNT New Initiatives, Beech (P.I.), Prichard, Dent, Geary, 2005-2007,

$60,000 FQRNT New Initiatives, Beech (P.I.), Prichard, Dent, Geary, 2007-2009, $60,000


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FQRNT New Initiatives, Stevenson (P.I.), Geary, Picirillo, 2007-2009, $60,000 Novartis Animal Health, Prichard (P.I), Geary, 2007-2009, $199,360 6. Honors and Awards received: 7. Refereeing and editorial work:

Associate Editor, Journal of Parasitology Editorial Board, Parasitology Co-Editor, Special Issue of Parasitology (with RK Prichard) Editorial Board, International Journal for Parasitology Refereed papers for: Molecular and Biochemical Parasitology; Parasitology Research; British Journal of Pharmacology; Infection and Immunity; Antimicrobial Agents and Chemotherapy; Veterinary Parasitology; Parasitology; FASEB Journal; Genomics; International Journal for Parasitology; Journal of Parasitology; Trends in Parasitology; Experimental Parasitology

Expert reviewer/referee: International Science and Technology Center (Russia/CIS) (January 2007); Science Foundation Ireland/site visit (May, 2007); WHO/TDR Drug Discovery programme (April 2007); Expert Scientific Advisory Committee, Gates Foundation (December 2007)

8. Other scientific activities Canadian Society of Zoologists Annual Meeting, Chair of Parasitology Symposium, Montreal, May 2007 North American Parasitology Conference, Chair of Chemotherapy session, Merida, Yucatan, Mexico, June 2007 WAAVP, Chair, Novartis Symposium, Ghent 2007 WAAVP, Chair of Anthelmintic Resistance session, Ghent 2007


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B. TEACHING AND GRADUATE STUDENT SUPERVISION (June 1, 2007 - May 31, 2008). 1. Courses taught and evidence of effectiveness: PARA515: Water, Health & Sanitation (course coordinator) Question 10=4.9 Question 21 (27)=4.7 BTEC535: Functional Genomics of Model Organisms Question 10=4.9 Question 21=4.8 Also lectured in MIMM413 (Parasitology); 2 lectures, no evaluation posted 2. Supervision of undergraduate projects:

Galen Guo (Honours, Microbiology, Macdonald Campus) 3. Graduate students currently being supervised:

Yovany Moreno, Ph.D. program in parasitology, 2006- Funding: stipend of $19,000 p.a. Jonathan Solomon, M.Sc. program in parasitology, 2006- Funding: NSERC Fellowship Vanessa Dufour, Ph.D. program in parasitology, 2008- Funding: FQRNT Fellowship

C. ADMINISTRATIVE AND OTHER ACADEMIC ACTIVITIES (June 1, 2007 - May 31, 2008) 1. Committees: McGill Technology Transfer, member (Faculty Senate); Library Committee, member (Macdonald); Admissions Committee, member (Institute of Parasitology); University Tenure Committee for Recruitment (Alternate) (2007); Recruitment for Chair of Animal Science (2007). Graduate student Ph.D. examiner: Kate Mounsey (Ph.D., Charles Darwin University, External Examiner); Manfred Fussi (M.Sc., External Examiner, McGill); Dana Prasličková (McGill University, External Examiner); Neeta Thawani, Ph.D., Experimental Medicine, McGill (External member); Aissatou Diawara, M.Sc., Parasitology, McGill (Internal Examiner); Amira Kassis, Ph.D., Dietetics and Human Nutrition, McGill (Pro-Dean).


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3. External activities:

Nominating Committee, American Association of Veterinary Parasitologists; Industrial Relations Committee, American Society of Parasitologists; Expert Drug Advisory Committee, WHO/TDR; Helminth Drug Initiative Steering Committee.

4. List administrative appointments:

Director, Institute of Parasitology

D. INTERNATIONAL ACTIVITIES (June 1, 2007 – May 31, 2008). None. E. CONSULTING ACTIVITIES (June 1, 2007 to May 31, 2008) Name: Timothy Geary Signature: __Timothy G. Geary




Pfizer, Inc., Retained Consultant, 2 days total

World Health Organization/Tropical Disease Research Steering Committee: Helminth Initiative, 7 days Drug Target Prioritization Committee, 2 days

Gates Foundation, 1 day

Novartis, Inc., 4 days

Divergence, Inc., Scientific Advisory Board, 2 days

Total : 8 Total: 9 Total:1


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Name: Elias Georges Date: August 2007 A. RESEARCH AND SCHOLARLY ACTIVITY 1. a) Publications in Refereed Journals: Bélisle JM, Costantino S, Leimanis ML, Bellemare MJ, Bohle DS, Georges E, Wiseman PW. Sensitive detection of malaria infection by third harmonic generation imaging. Biophys J. 2008 Feb 15;94(4):L26-8. Georges, E. The P-glycoprotein (ABCB1) linker domain encodes high-affinity binding sequences to alpha- and beta-tubulins. Biochemistry. 2007 Jun 26;46(25):7337-42. Laberge RM, Karwatsky J, Lincoln MC, Leimanis ML, Georges E. Modulation of GSH levels in ABCC1 expressing tumor cells triggers apoptosis through oxidative stress. Biochem Pharmacol. 2007 Jun 1;73(11):1727-37. Leimanis ML, Georges E. ABCG2 membrane transporter in mature human erythrocytes is exclusively homodimer. Biochem Biophys Res Commun. 2007 Mar 9;354(2):345-50. 2. Conference Presentation and Invited Lectures Laberge R.M. and Georges E. 2007. Collateral Sensitivity in Multidrug Resistant Tumor Cells modulated by P-glycoprotein (P-gp1). Annual North American ABC Meeting October 4-5, 2007 Frederick, MD, USA. Oral Presentation. Laberge R.M., Lian J. and Georges E. 2007. P-glycoprotein (P-gp1) as direct modulator of collateral sensitivity in multidrug resistant tumor cells. AACR Annual Meeting. April 14-18, 2007, Los Angeles, CA, USA. Poster Edaye, S., Richard-Lalonde, M., Leimamis, M.L., and Georges, E. Plasmodium falciparum drug resistance: Implication of a putative ABC transporter. Seventh Annual Quebec Parasitology Symposium, June 13-14, 2008 at Complex des Science (UQAM), Montreal QC.

Invited Presentations.

Georges, E. “Biomarkers in Breast and Ovarian Cancers” July 19, 2007, at BioSite Inc. San Diego, CA. Georges, E. “Ovarian Cancer: Predicting Patients’ Response to Chemotherapy” Feb. 2008, at DebioVision Inc. Montreal, QC.


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5. Grants Held: 2005 – 2006 National Sciences and Engineering Research Council of Canada (NSERC). The multidrug resistance-associated protein (MRP): Molecular mechanisms of drug binding and transport $40,000 (Operating Grant) Georges, E. FQRNT (New Initiatives Fund, FQRNT-Center Grant) Development and Characterization of Novel Ozonides (trioxolanes) as Effective Antimalarial Drugs $30,400 (Operating Grant) Georges, E (PI), Spithill, T and Just, G. YM Biosciences Inc. A public Biotechnology Company in Toronto “Molecular Mechanism of Tesmilefene in Breast Cancer” $179,241 (Contract) Amount of this contract was spread over the two year period. National Institute of Health Expression of ABC transporters in Pichia pastoris $145,011 (US) Gros, P. (PI), Cai, J. and Georges, E. Grants Held: 2006 – 2007 National Sciences and Engineering Research Council of Canada (NSERC). The multidrug resistance-associated protein (MRP): Molecular mechanisms of drug binding and transport $40,000 (Operating Grant) Georges, E. FQRNT (New Initiatives Fund, FQRNT-Center Grant) Development and Characterization of Novel Ozonides (trioxolanes) as Effective Antimalarial Drugs $30,400 (Operating Grant) Georges, E (PI), Spithill, T and Just, G. YM Biosciences Inc. A public Biotechnology Company in Toronto “Molecular Mechanism of Tesmilefene in Breast Cancer” $179,241 (Contract) Amount of this contract was spread over the two year period. National Institute of Health Expression of ABC transporters in Pichia pastoris $145,011 (US) Gros, P. (PI), Cai, J. and Georges, E.


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Grants Held: 2007 - 2008 National Sciences and Engineering Research Council of Canada (NSERC). The multidrug resistance-associated protein (MRP): Molecular mechanisms of drug binding and transport $40,000 (Operating Grant) Georges, E. National Institute of Health Expression of ABC transporters in Pichia pastoris $145,011 (US) Gros, P. (PI), Cai, J. and Georges, E. 7. Refereeing and Editorial Work I review for the following journals: Cancer Research; Journal of Biological Chemistry; Biochemistry; The Journal of Parasitology; and Experimental and Molecular Pathology. Grants: Canadian Institute of Health Research; and National Sciences and National Cancer Institute of Canada. Canadian Liver Foundation. Alberta Research foundation. 8. Patents A patent application entitled “A Protein Extraction buffer, a kit comprising it and method of its use”. Utility patent filed in US by Hale and Dorr on Sept 12, 2007 Application no.11/900,671. A patent application entitled “ABP42-Directed Diagnostics for Neoplastic Disease”. Provisional patent filed in US by Hale and Dorr on Sept 12, 2007 Application no. 60/993,572. A patent application entitled “ABP56-Directed Diagnostics for Neoplastic Disease”. Provisional patent filed in US by Hale and Dorr on Sept 12, 2007 Application no.60/993,377. A patent application entitled “ABP61-Directed Diagnostics for Neoplastic Disease”. Provisional patent filed in US by Hale and Dorr on Sept 13, 2007 Application no. 60/993,576. A patent application entitled “ABP-125-Directed Diagnostics for Neoplastic Disease”. Provisional patent filed on January 29, 2008 in US by Hale and Dorr . Application no. 60/024,430. A patent application entitled “ABP-126-Directed Diagnostics for Neoplastic Disease”. Provisional patent filed on January 29, 2008 in US by Hale and Dorr . Application no. 60/024,435.


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A patent application entitled “ABP127-Directed Diagnostics for Neoplastic Disease”. Provisional patent filed on January 29, 2008 in US by Hale and Dorr . Application no. 61/024,428. A patent application entitled “ABP128-Directed Diagnostics for Neoplastic Disease”. Provisional patent filed on January 29, 2008 in US by Hale and Dorr . Application no. 61/024,422. A patent application entitled “ABP129-Directed Diagnostics for Neoplastic Disease”. Provisional patent filed on January 29, 2008 in US by Hale and Dorr. Application no. 61/024,441.

B. TEACHING AND GRADUATE STUDENT SUPERVISION 1. Teaching (Biotechnology Certificate Courses) Course Coordinator: Biotechnology Management Course 394-621A

I give the first lecture of the course. Speakers are selected from various sectors of the Biotech industry. Attend most lectures and initiate discussions and clarification. In the fall of 2008, I introduced a new component to the list of lectures “a group project presentations”. The class was divided into five groups of four students and each group made two presentations on a hypothetical NewCo. The second presentation was done in the presence of three judges, myself, Dr. Charlie Fong and Mr. Serge Langford “ the latter two are Investment Directors working at the BDC and Multiple Capital Venture Investment firms”.

Assessment for this course is one final report of 5-8 pages.

Course Coordinator: Biotechnology Practicum Course 394-691. The objective of this course is to place in Industry laboratories for a 12 weeks Stage working on a research project designed to yield results and a final report by the end of Stage. At the end of the 12 weeks, each student writes a report “manuscript style”, that includes all of the experimental results in the project. Students are assessed on one final report.

Course Coordinator: Biotechnology Research Internship BTEC 622-625 The Research Internship is divided into four courses 622, 623, 624, and 625. The internship begins with the placement of students in Industry or Research labs in Quebec or outside Quebec for a minimum of 16 weeks. Following their placement, initial draft of project objectives is presented and discussed with the immediate supervisor of the student. The latter draft is then approved or modified by each student committee (three members committee) as part of research proposal marked by all committee members. Each student is expected to submit four progress reports and two evaluations done by immediate supervisor. All students give a final oral presentation and a report.


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Director of Biotechnology Graduate Programs: The biotechnology graduate program continues on a growth path in spite of the down

sizing of the Quebec biotechnology industry and establishment of other biotechnology training programs; in Quebec and Internationally. This program, with the help of many faculty, staff and students continues to improve through the addition of complementary courses and laboratory updates. Over the past year, we have established a highly successful MSc (A) program that is internationally recognized (as an example, see last page of this document for an attached email from Japan).

A major attraction and continual success of this program has been our record of student placement in industry (65-80% placement in industry laboratories). The coordination of the program is very time intensive, and not possible without Mr. C. Trudeau’s watchful eyes and coordination, but equally rewarding.

3. Graduate Students

b) List of students currently being supervised: It should be stressed at this point that I act as a co-supervisor/committee member of all students registered to the MscA in Biotechnology.

1. Mara Leimanis

2001- 2008 Ph.D. Student. Research Project: “Drug resistance in malaria P. falciparum: Role of host ABC transporters”.

Total of 4 publication; two in preparation. 2. Rémi-Martin Laberge

2004 - Ph.D. Student Research Project: “Overcoming drug resistance: Characterization of a multi-drug resistance ABC transporter MRP1, and its role in collateral sensitivity Two publications (one published and one in press), two in preparation.

3. Raghuram Ambadipudi 2008- Ph.D. Student Research Project: “Identification of ABC Interacting Proteins using A Novel Protein-protein Interaction Method” Co-author on two manuscripts in preparation 4. Melissa Richard-Lalonde

2007 summer NSERC Summer trainee Research Project: “Cloning of Plasmodium Falciparum ABCG-like gene”


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5. Sonia Edaye 2008 Student Trainee

Research Project: “Characterization of PfABCG protein in Plasmodium Falciparum”

C. ADMINISTRATIVE AND OTHER ACADEMIC ACTIVITIES

Institute Faculty Position Selection Committee: Member FAES Ethics Committee: Member Faculty of Management Tenure Committee: Member Faculty of Library Tenure Committee: Member

Biotechnology Students Admission Committee: Chair Purchase of New Instruments Committee: Member McGill Library Committee: Member 25 Graduate Student Committees (including the Biotech. MSc.A graduate students’ committees): Member

Two Ph.D. Oral defense Examination: Internal Examiner & Committee member

E. CONSULTING (June 1, 2007 - May 31, 2008) Here indicated are the number of days allocated to Consulting Activities for the period June 1, 2007 to May 31, 2008 in each of the following categories : Name : _Elias Georges____ Signature : __Elias Georges_________




Aurelium BioPharma

YM Biosciences Inc.

Canadian Breast Cancer Foundation- Fellowship Rev.

Total : 44 days a month Total: 4 days Total: 48 Days


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From: John A. Tessensohn [mailto:[email protected]] Sent: Mon 8/18/2008 2:51 AM To: Elias Georges, Prof. Subject: Entry level Graduate Position - Biotech Specialist - Osaka/Japan - Closing date Aug. 29, 2008

Dear Director Georges: I trust that this e-mail finds you well and in good health. I am the hiring attorney of a progressive & international full service patent law firm in Osaka, Japan. Our Firm has been reported by Nature 437:1061 (October 2005) as "a leading biotechnology intellectual-property firm" in Osaka. We have a growing global patent practice representing major Japanese & Foreign MNCs in the worldwide protection and enforcement of patents & trademarks. We represent cutting edge healthcare companies like Amgen, Biogen-IDEC, Genentech, Novartis, Schering-Plough & Wyeth. It is widely known that your Biotechnology Graduate Programs have an unequaled reputation as one of the best in the field, which is why we would like to recruit suitable masters graduates from your esteemed institution for Biotech Specialists to be based in Osaka for three years. International graduates are also especially welcome to apply for the position. We are seeking candidates who are your alumni or final year graduating students to take up the entry level position of Biotech Patent Analysts to commence employment in Osaka before end 2008. We would greatly appreciate it if you could post it on your Dept. Notice Board until Aug 29, 2008. Please feel free to circulate to graduating students who may be interested in working overseas and being exposed to the cutting-edge healthcare technologies. Thank you very much for your kind assistance and co-operation. John A. Tessensohn, Esq. SHUSAKU YAMAMOTO 15th FLOOR CRYSTAL TOWER, 1-2-27 SHIROMI OSAKA, 540-6015 JAPAN TELEPHONE: +81-6-6949-3910 FACSIMILE: +81-6-6949-3915 EMAIL: [email protected] http://career.shupat.gr.jp/index_e.html


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McGill University, Faculty of Agricultural and Environmental Sciences


Name: Armando Jardim Appointments: Institute of Parasitology and Department of Microbiology and Immunology Director for the FQRNT Centre for Host Parasite Interactions Date: June 1, 2007

A. RESEARCH AND SCHOLARLY ACTIVITY 1. PUBLICATIONS: a) REFEREED JOURNALS 1. Pilar, A.V., Madrid, K.P., and Jardim, A. (2008) Interaction of Leishmania

PTS2 receptor peroxin 7 with the glycosomal protein import machinery. Mol Biochem Parasitol. 158, 72-81.

b) OTHER PUBLICATION 1. Jardim, A. (2007) Lecture notes for Biochemistry I (FDSC211), revised edition 2. Jardim, A. (2007) Proteomics Laboratory Manual for the Biotechnology 619B

Laboratory Course in the Master of Science in Biotechnology (Applied), revised edition

2. CONFERENCE PRESENTATIONS AND INVITED LECTURES: 1 Jardim, A. “Leishmania donovani Glycosomal Protein Import Machinery”

(2007) COST B22 Working Group 5 Drug resistance in parasitic protozoa and CIHR Group Leishmania satellite meeting, Unviersite du Laval, Quebec City, QC, Canada

2. Jardim, A. Leishmania Glycosome Assembly Machinery (2007) Département

de Pathologie et Microbiologie, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, QC, Canada

3. Caballero-Franco, C., Dufresne, L., and Jardim, A. (2007) Characterization of

the Interaction of the Secreted Proteins EspB and EspD in enteropathogenic E. coli. 46th Annual Meeting of the Canadian Society of Zoologists. Montreal, QC, Canada


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4. Nyisztor, M. and Jardim, A. (2007) The Interaction of Leishmania donovani Peroxin 14 with the Glycosomal Membrane Involves the Conserved N-terminal Region. 46th Annual Meeting of the Canadian Society of Zoologists. Montreal, QC, Canada

5. Pilar, A.V.C. and Jardim, A. (2007) Subcellular Localization of the PTS2

receptor LmPEX7 in Leishmania donovani. 46th Annual Meeting of the Canadian Society of Zoologists. Montreal, QC, Canada

5. EXTRAMURAL FUNDING (GRANTS HELD):

1. A. Jardim (principal investigator) “The role of Leishmania donovani LdPEX5 in protein import into the glycosomal organelle” NSERC Discovery Grant Program

period of funding 2006-2009 at $31, 500/yr (renewal) 2. A. Jardim (principal investigator)

“Glycosome biogenesis in the protozoan pathogen Leishmania: The role of Leishmania donovani LdPEX14 in protein targeting and import” CIHR Operating Grant period of funding 2004-2009 at $89, 820/yr (renewal)

3. T. Spithill (principal investigator), A. Jardim (co-applicant), P. Ribeiro, R. Beech, M.

Scott, R.Prichard, G. Faubert, E. Georges, K. Chadee, J. Dent, A. Descoteaux, G. Fecteau,K.Koski, G. Matlashewski, M. Olivier, M.Ouellette, B. Papadopoulou,S.Sato, M.Stevenson, A. Villeneuve, B.Ward, H.Charest. FQRNT Regroupments Strategiques period of funding 2003-2009

4. H. Bennett (principal investigator), A. Jardim (co-applicant), J. Coulton, K. Gehring, G.

Hendy, H. Le-Moual, J. Pelletier, N. Sonenberg, G. Decrescenzo. “Multi-User Protein-Protein Interaction Facility” CIHR Multi-user Maintenance Grant period of funding 2007-2010 at $50,000/yr EXTRAMURAL GRANTS (APPLIED FOR):

1. FQRNT Equipe “The role of MIF in Malaria Infection” Applicants T. Scorza, A. Jardim and M. Olivier

2. Gates Grand Challenge Exploration “A Novel Class of Drugs that kill African

Trypanosomes and Leishmania Parasites with eC50 in the Picomolar Range. Applicants A. Jardim (PI), M. Lee

7. REFEREEING AND EDITORIAL WORK:

1. Molecular and Biochemical Parasitology (Editorial Board Member) 2. Protein Sciences (ad hoc reviewer)


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B. TEACHING AND GRADUATE STUDENT SUPERVISION

1. COURSES TAUGHT AND EFFECTIVENESS: a) UNDERGRADUATE TEACHING: SCORES Quest # 10 Quest #21 a) FDSC 211 Biochemistry I section I ** 4.3 3.9

b) GRADUATE TEACHING: SCORES Quest # 10 Quest #21

a) Biotechnology Laboratory Techniques section I** 4.3 3.8 Course 394-619B (course coordinator) section II** 4.0 4.0

** values are not reliable since only 58% responded for FDSC 211 and 11% & 50% for the BTEC 619B 2. UNDERGRADUATE STUDENT SUPERVISION: a) Sarah LaLonde Summer Research project (McGill, Physiology) 3. GRADUATE STUDENT AND POSTDOCTORAL SUPERVISION: Student Program Enrolment Year Support/yr

1. Ana V. Pilar (Ph.D. Candidate) 2002 $ 18,000 2. Celia Caballero-Franco (Ph.D. Candidate) 2004 $18, 000 3. Normand Cyr (Ph.D. Candidate)) 2006 FQRNT

Fellowship 4. Mathieu Cambos (Ph.D. Candidate) 2005 (co-supervised with T. Scorza at UQAM) 5. Shilpa Lakshmi (M.Sc. Candidate) 2007 6. Rona Strasser (Ph.D. Candidate) 2007 7. Hiren Banerjee (PDF) 2007 $ 37, 000

4. STUDENT GRADUATED 1. Michael Nyisztor M. Sc. (2007)


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C. ADMINISTRATIVE AND OTHER ACADEMIC ACTIVITIES 1. COMMITTEES: a) University Tenure Committee (Faculty of Science) b) Faculty:

1. Academic Program Committee 2. Faculty Agricultural and Environmental Sciences Undergraduate Admissions

Committee

c) Departmental: 1. Fellowships Committee member 2. Graduate Student Admission Committee Parasitology member 3. Faculty Recruitment Committee (Parasitology) member

(Dr. J. Dalton) 4. M.Sc. (Applied) Biotech Admissions Committee member 5. Certificate in Biotech. Admissions Committee member 6. Curriculum Committee member 7. Board Member for the FQRNT Centre for Host-Parasite Interaction

2. ACADEMIC ADVISING: Graduate Student Thesis Committees: 2. Mr. M. Osei-Atweneboana (Ph.D.) Advisor- Dr. R. Prichard 4. Mr N. Patocka (Ph.D.) Advisor-Dr. Ribeiro 4. Ms. A. Tamara (Ph.D.) Advisor-Dr. Ribeiro 5. Mr. H. Moshiri (M.Sc.) Advisor Dr.R. Salavati

6. Ms. K. Yam (Ph.D.) Advisor Dr. B. Cousineau

Graduate Thesis Examination Committees: Eric Bottos Biodiversity and activity of microbial mat communities

M.Sc. from Canadian high Arctic ice shelf ecosystems: Whyte, L. (2007)


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3. OTHER: 1. Director of the Institute of Parasitology Molecular Biology Core Facility 2. Director, FQRNT/McGill Centre for Host-Parasite Interactions

D. INTERNATIONAL ACTIVITIES: 1. INTERNATIONAL COLLABORATION: 1. Glycosome Biology Dr. Milind S. Patole Scientist Cell Repository

National Centre for Cell Science, University of Pune, Ganesh Khind, Pune 411007 INDIA

2. Drug Discovery for Leishmania and African Trypanosomes Dr. Moses Lee, Hope College, New Holland, MI

3. Genetic and Proteomic Approach to Discovery of Immunogenic Leishmania Proteins for Immunization and Development Diagnostic Tests Dr. Ricardo Gazzinelli, Division of Infectious Diseases and Immunology, Department of Medicine, UMASS Medical School and at Oswaldo Cruz Foundation / Federal University of Minas Gerais

E. CONSULTING:

1. CIHR grant review (ad hoc 2 days) 2. External NSERC grant reviewer (ad hoc 1 day) 3. Upstream Biosciences Inc (1 day/month)


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Name: Roger Prichard Date: June 10, 2008 A. RESEARCH AND SCHOLARLY ACTIVITY 1. Publications, calendar 2007: a) REFEREED Journals: Schwab, A.E., Churcher, T.S., Schwab, A.J., Basáñez, M-G. & Prichard, R.K. (2007) An analysis of the population genetics of potential multi-drug resistance in Wuchereria bancrofti due to combination Chemotherapy. Parasitology 134: 1025 – 1040. Mackenzie, C., Geary, T., Prichard, R. and Boussinesq, M. (2007) Where next with Loa loa encephalopathy? - Data are badly needed! Trends Parasitol. 23: 237-238. Osei-Atweneboana, M.Y., Eng, J.K.L., Boakye, D.A., Gyapong, J.O. & Prichard, R.K. (2007) Prevalence and intensity of Onchocerca volvulus infection and efficacy of ivermectin in endemic communities in Ghana: a two phase epidemiological study. Lancet 369: 2021 – 2029. Prichard, R. K., von Samson-Himmelstjerna, G., Blackhall, W. J. & Geary, T. G. (2007) Foreword: Towards markers for anthelmintic resistance in helminths of importance in animal and human health. Parasitology 134: Special Issue 08: 1073-1076. Prichard, R.K. (2007) Markers for benzimidazole resistance in human parasitic nematodes? Parasitology 134: Special Issue 08: 1087-1092. Prichard, R. K. & Roulet, A. (2007) ABC transporters and β-tubulin in macrocyclic lactone resistance: prospects for marker development. Parasitology 134: Special Issue 08: 1123-1132. Bourguinat, C., Pion, S.D.S., Kamgno, J., Gardon, J., Duke, B.O.L., Boussinesq, M. & Prichard, R.K. (2007) Genetic selection of low fertile Onchocerca volvulus by ivermectin treatment. PLoS Neg. Trop. Dis. 1(1)e72: 12-22. Osei-Atweneboana, M.Y., Eng, J.K.L., Boakye, D.A., Gyapong, J.O. & Prichard, R.K. (2007) Efficacy of ivermectin against Onchocerca volvulus in Ghana. Lancet 370: 1124-1125.


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Prichard, R.K. Ivermectin resistance and overview of the Consortium for Anthelmintic Resistance SNPs. Expert Opin. Drug Discov. (2007) 2(Suppl.1):S41-S52. Ardelli, B.F. & Prichard, R.K. (2007) Reduced genetic variation of an Onchocerca volvulus ABC transporter gene following treatment with ivermectin. Trans Roy. Soc. Trop. Med. Hyg. 101: 1223-1232. Junnila, A., Bohle, S., Prichard, R., Perepichka, I. & Spina, C. (2007) Fluorescent diethylcarbamazine analogs: Sites of accumulation in Brugia malayi. Bioconjugate Chem. 18: 1818–1823. In press, Dec. 31, 2007: Mottier, M.L. & Prichard, R.K. (2008) Genetic analysis of a relationship between macrocyclic lactone and benzimidazole anthelmintic selection on Haemonchus contortus. Pharmacogenetics & Genomics, 18: 129–140. Bourguinat, C., Ardelli, B.F., Pion, S.D.S., Kamgno, J., Gardon, J., Duke, B.O.L., Boussinesq, M., & Prichard, R.K. (2008) P-glycoprotein-like protein, a possible genetic marker for ivermectin resistance selection in Onchocerca volvulus. Molecular & Biochemical Parasitology, 158: 101-111. Blackhall, W.J., Prichard, R.K. & Beech, R.N. (2008) P-glycoprotein selection in strains of Haemonchus contortus resistant to benzimidazoles. Veterinary Parasitology, 152: 101-107. Prichard, R.K. & Geary, T.G. (2008) Fresh hope to can the worms. Nature, 452(7184): 157-158. Churcher, T.S. Schwab, A.E., Prichard, R.K. & Basáñez, M-G. An analysis of genetic diversity and inbreeding in Wuchereria bancrofti: implications for the spread and detection of drug resistance. PLoS Neg. Trop. Dis., in press. Book Chapters: Prichard, R. (2008) Drug Resistance in Nematodes. In: Antimicrobial drug resistance: Principles and practices for the clinic and bench. (Eds. D. Mayers, S. Lerner, J. Sobel & M. Ouellette), Humana Press. von Samson-Himmelstjerna G, Prichard RK, Wolstenholme AJ in press. Anthelmintic resistance as a guide to the discovery of new drugs. In: Drug Discovery in Infectious Diseases (Ed. P. Selzer), Wiley-VCH.


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b) REFEREED Conference Proceedings: See list below under Conference papers. c) Other publications: e) Co-authors affiliation: Eng J., Ph.D. student, Parasitology Ardelli, B., postdoctoral fellow, Parasitology Bourguinat, C., Ph.D. student, Parasitology Pion, S.D.S., postdoctoral fellow, Imperial College, London Kamgno, J., Pasteur Institut, Cameroon Gardon, J., IRD, Bolivia Duke, B.O.L., River Blindness Foundation, UK Boussinesq, M., IRD, France Boakye, D., Noguchi Memorial Medical research Institute, Ghana Schwab, A.E., Ph.D. student, Parasitology von Samson-Himmelstjerna, G., Institute of Parasitology, Hannover, Germany Churcher, T.S., Ph.D. student, Imperial College, UK Schwab, A.J., Montreal General Hospital Basáñez, M.G., Imperial College, UK Blackhall W.J., former Ph.D. student, Institute of Parasitology, now Institute of Parasitology, Hannover, Germany Osei-Atweneboana M.Y., Ph.D. student, Parasitology Beech R.N., Institute of Parasitology Mackenzie C., University of Michigan, East Lansing MI, USA Geary T.G., Institute of Parasitology Gyapong J., Ministry of Health, Accra, Ghana Roulet A., postdoctoral fellow, Parasitology Junnila A., Ph.D. student, Parasitology Bohle S., Dept. Chemistry, McGill University Perepichka I., postdoctoral fellow, Chemistry, McGill University Spina C., postdoctoral fellow, Chemistry, McGill University Mottier M.-L., postdoctoral fellow, Parasitology Wolstenholme A., University of Bath, Bath, UK

2. Conference presentations and invited lectures, 2007: Invited Conference Papers and Lectures, 2007 Prichard, R.K. SNP markers for anthelmintic resistance. WHO Scientific Working Group Meeting on Helminth Initiative (with Japanese Parasitological Society) 22 - 24 January, 2007, University of Tokyo, Tokyo, Japan


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Prichard, R.K. Mechanisms of macrocyclic lactone resistance. British Society of Parasitology, Belfast, UK, 15-18 April, 2007. Prichard, R.K. Mechanisms of resistance to macrocyclic lactones: Overview and recent findings. Fort Dodge Animal Health Symposium on Anthelmintic Resistance. Athens, Greece, 11-12 May, 2007. Prichard, R.K. Some implications from genetic diversity in parasitic nematodes. First North American Parasitology Congress, Mérida Yucatán, México. June 21-25, 2007. Prichard, R.K. Drug resistance in parasitic nematodes of humans and animals: the global situation and mechanisms of resistance. European Union, COST B22 Working Group 5 Meeting on Drug Resistance in Parasites, Quebec, QC, Canada. October 22-24, 2007. Prichard, R.K. Current knowledge about drug resistance and detection tools in the use of IVM for the treatment of ONCHO, LF, ascariasis and trichuriasis. World Health Organization – World Bank meeting on Monitoring Drug Efficacy in Large Scale Treatment Programmes for Human Helminthiasis, Washington, DC, USA. October 31 – November 2, 2007. Prichard, R.K. Parasite control, threats and opportunities. Department of Microbiology and Parasitology, Makerere University, Kampala, Uganda. December 11, 2007. Other Conference Papers and Lectures, 2007 Mottier, M.L., Eng, J.K.L., Prichard, R.K. Ivermectin and Moxidectin Selection on β-tubulin: relevance for drug resistance in Haemonchus contortus and Onchocerca volvulus. British Society of Parasitology, Belfast, UK, 15-18 April, 2007. Mottier, M.L., Prichard, R.K. Macrocyclic lactones selection on β-tubulin in Haemonchus contortus: Implications for cross-resistance selection to benzimidazole and macrocyclic lactone anthelmintics. Fort Dodge Animal Health Symposium on Anthelmintic Resistance, Melbourne, Australia. 2-3 May, 2007. Bourguinat, C., Ardelli, B., Pion, S.D.S., Kamgno, J., Gardon, J., Duke, B.O.L., Boussinesq, M., Prichard, R.K. P-glycoprotein-like protein, a possible genetic marker to follow potential ivermectin resistance in Onchocerca volvulus. 46th Annual Meeting of the Canadian Society of Zoologists, Montreal, Canada. 21-25 May, 2007. Osei-Atweneboana, M., Eng, J.K.L., Boakye, D.A., Gyapong, J.O., Prichard, R.K. Responses of Onchocerca volvulus to repeated rounds of ivermectin treatment in Ghana. 46th Annual Meeting of the Canadian Society of Zoologists, Montreal, Canada. 21-25 May, 2007. Rao, V., Prichard, R.K., Forrester, S. Cloning and characterization of a novel ligand-gated chloride channel in Haemonchus contortus. 46th Annual Meeting of the Canadian Society of Zoologists, Montreal, Canada. 21-25 May, 2007.


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Prichard, R.K., Bourguinat, C., Eng, J. IVM resistance and IVM selection on β-tubulin and an ABC-transporter in O. volvulus: possible SNP markers. 2nd CARS Workshop, Ghent, Belgium. 18 August, 2007. Prichard, R.K., Mottier, M.L. ML selection on tubulins in H. contortus: SNP sites. 2nd CARS Workshop, Ghent, Belgium. 18 August, 2007. Mottier, M.L., Prichard, R.K. Macrocyclic lactones selection on beta-tubulin in Haemonchus contortus: Implications for cross-resistance selection to benzimidazole and macrocyclic lactone anthelmintics. 21st International Conference of the World Association for the Advancement of Veterinary Parasitology. Ghent, Belgium, August 19-23, 2007. van Zeveren, A.M., Geldhof, P., Alvinerie, M., Prichard, R., Claerebout, E., Vercruysse, J. Experimentally induced ivermectin resistance in Ostertagia ostertagi in cattle. 21st International Conference of the World Association for the Advancement of Veterinary Parasitology. Ghent, Belgium, August 19-23, 2007. Diawara A., Drake, L.J., Suswillo, R.R., Bundy, D.A., Prichard, R.K. Development of DNA assay in soil-transmitted nematodes of humans for the detection of single nucleotide polymorphisms (SNPs) associated with benzimidazole resistance. Centenary Meeting, Royal Society for Tropical Medicine and Hygiene, Sept., 2007, London, UK. Diawara, A., Drake, L.J., Suswillo, R.R., Bundy, D.A., Prichard, R.K. Development of DNA assay in soil-transmitted nematodes of humans for the detection of single nucleotide polymorphisms (SNPs) associated with benzimidazole resistance. Annual Meeting American Society for Tropical Medicine and Hygiene, Nov. 4-8, 2007, Philadelphia, PA, USA. Osei-Atweneboana, M.Y., Eng, J.L., Boakye, D.A., Gyapong, J.O., Prichard, R.K. Phenotypic evidence of emerging ivermectin resistance in some populations of Onchocerca volvulus, the causative agent of onchocerciasis. Annual Meeting American Society for Tropical Medicine and Hygiene, Nov. 4-8, 2007, Philadelphia, PA, USA. Bourguinat, C., Ardelli, B.F., Pion, S.D., Kamgno, J., Gardon, J., Duke, B.O., Boussinesq, M., Prichard, R.K. P-glycoprotein-like protein, a promising genetic marker to follow potential ivermectin resistance in Onchocerca volvulus. Annual Meeting American Society for Tropical Medicine and Hygiene, Nov. 4-8, 2007, Philadelphia, PA, USA. Yusibov, V.M., Knapp, E., Flores, F., Steger, K., Goldschmidt, M., Lubega, G., Namayanja, M., Prichard, R., Keller, K., Holtzman, D. α or β tubulin subunit vaccine candidates protect against challenge with Trypanosma brucei. Annual Meeting American Society for Tropical Medicine and Hygiene, Nov. 4-8, 2007, Philadelphia, PA, USA. 3. Supervision of postdoctoral fellows and visiting scientists, 2007-08: Dr. Catherine Bourguinat commenced post-doctoral studies in October, 2007 Dr Rodrigo Miranda completed his Ph.D. in Brazil and obtained a postdoctoral fellowship from the Government of Canada. He commenced postdoctoral studies in February, 2008.


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4. Organization of advanced seminars: Principal Coordinator of the International Consortium for Anthelmintic Resistance SNPs Workshop, Gent, Belgium, 2007 FQRNT/CHPI Annual Scientific Meeting/CSZ Annual Meeting, May, 2007, LOC Member Scientific Program Committee, ICOPA, Melbourne Coordinator, Anthelmintic Resistance Symposium, WAAVP, Ghent, Belgium Chair Scientific Programme Committee for the 2009 World Association for the Advancement of Veterinary Parasitology biennial Conference, Calgary, AB, Canada 5. Grants held (PI bolded): Year Grantee(s) Agency Type Amount $ Can ___________________________________________________________________________ 2005/2006 Prichard NSERC Res 78,075 Prichard McGill James McGill 10,000 Prichard Glaxo Op 27,400 Prichard, Beech Fort Dodge Contr 140,000 Prichard et al CFI IOF 288,000 Yusibov, Lubega, Prichard Gates Fdn Op 600,000 Spithill, Prichard et al FQRNT Centre 360,000 Spithill, Prichard et al McGill Centre 90,000 Beech, Prichard et al CHPI New Initiative 30,000 2006/2007 Prichard NSERC Res 85,732 Prichard McGill James McGill 10,000 Prichard World Bank FRESH 19500 Prichard et al CFI IOF 288,000 Prichard, Beech Fort Dodge Contr 140,000 Yusibov, Lubega, Prichard Gates Fdn Op 600,000 Boussinesq, Prichard et al ANR, France Health & Envir €213,000 Spithill, Prichard et al FQRNT Centre 360,000 Spithill, Prichard et al McGill Centre 90,000 Prichard, Geary Novartis Contr 106,000 2007/2008 Prichard NSERC Res 85,732 Prichard McGill James McGill 10,000 Prichard et al CFI IOF 288,000 Prichard, Beech Fort Dodge Contr 140,000 Prichard, Geary Novartis Contr 106,000 Yusibov, Lubega, Prichard Gates Fdn Op 600,000 Boussinesq, Prichard et al ANR Health & Envir €213,000 Spithill, Prichard et al FQRNT Centre 360,000 Spithill, Prichard et al McGill Centre 90,000 Prichard CIHR Research 75,530


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6. Honours and Awards received:

James McGill Chair Elected Fellow, Australian Society for Parasitology Invited by the journal Nature to write a News & Views article on a new drug devopment

7. Refereeing and editorial work: Member of the Editorial Board of Veterinary Parasitology Member of Editorial Board of PLoS Neglected Tropical Diseases Referring for: Journal of Parasitology

Veterinary Parasitology Molecular and Biochemical Parasitology Trends in Parasitology Parasitology International Journal of Parasitology PLoS NTD Pharmacogenetics and Genomics

Grant reviews for: CFI College of Reviewers

NSERC MRC, UK BBSRC, UK The Wellcome Trust

8. Other scientific activities: Coordinator of the International Consortium for Anthelmintic Resistance SNPs B. TEACHING AND GRADUATE STUDENT SUPERVISION (June 1, 2006-May 31, 2007) 1. Courses taught and effectiveness: PARA635 Cell Biology and Infection; coordination and teaching Q10 = 4.4; Q21 = 4.1 PARA655 Host-Parasite Interactions; taught 9 hours

2. Supervision of Undergraduate projects: Gaelle Bekolo, in B.Sc. Microbiology and Immunology program. Project: Phenotype evaluations of experimental anthelmintics on Caenorhabditis elegans 3. Graduate Student Supervision: Students being supervised who completed during 2007-2008:

Catherine Bourguinat, Ph,D. Aissatou Diawara, M.Sc.

Current (2007-2008 and ongoing) Graduate Students:

Mike Osei-Atweneboana, Ph.D., Government of Ghana Vijay Rao, Ph.D. student, FQRNT Bourse. Co-supervised by Dr Sean Forrester Aissatou Diawara, Ph.D. student, supported at $18,000 p.a. Andrea Rauba, M.Sc. student, NSERC Graduate Fellowship Pablo Godoy, M.Sc. student, MIDEPLAN Fellowship, Chile

Postdoctoral fellows: Catherine Bourguinat, co-supervise with Prof. T. Geary Rodrigo Miranda, Government of Canada International Fellowship

C. ADMINISTRATIVE AND OTHER ACADEMIC ACTIVITIES 1. Departmental activities: Graduate Admissions Committee, Chair P.I. on CFI ($12,000,000) and CFI-IOF ($1,440,000) grants bringing major infrastructure to Institute of Parasitology and Faculty Associate Director, FQRNT Centre for Host-Parasite Interactions Acting Director, FQRNT Centre for Host-Parasite Interactions to September 1, 2007 Search Committee for CRC Chair


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2. University and Faculty activities: Faculty Planning Committee, Chair Faculty Nominating Committee, Chair Chair Organizing Committee, Faculty Retreat, 2006 Coordination of Honorary Degree recipient for 2007, Convocation Member of University Tenure Committee for the Desautels Faculty of Management Member of University International Advisory Committee to VPRIR 3. External activities: Invited external member European Union COST16 Action Committee on Drug Resistance Invited Examiner on European Union PARASOL project (€10,000,000) 4. Other professional activities: D. INTERNATIONAL ACTIVITIES 1. Development of a vaccine against Trypanosomiasis a) Project Director: Dr Vidadi Yusibov, Fraunhofer Center, Newark, DE, USA b) Research c) Gates Foundation funding; d) Partner countries, USA, Uganda and Canada e) 2 years, ongoing 2. Modeling anthelmintic resistance development and spread in Lymphatic Filariasis and Onchocerciasis a) Collaboration with Dr Maria-Gloria Basanez, Imperial College, London, UK b) Research and training c) MRC, UK, 5 vears of funding to Dr Basanez d) UK, France, Cameroon, Canada e) 5 years 3. Ivermectin effects on genetic selection and reproduction phenotype in Onchocerca volvulus a) Collaboration with Dr Michel Boussinesq, Institut de recherché en development, Paris, France b) Research and training c) WHO, IRD, River Blindness Foundation d) Canada, France, Cameroon, UK e) 3 years


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4. Detection of Albendazole resistance genetic changes in Human Soil Transmitted Nematodes a) Collaboration with Dr Lesley Drake, Imperial College, London, UK b) Research, training and development c) World Bank d) UK, Kenya, Canada e) 2 years 8. Longitudinal study of responsiveness of Onchocerca volvulus in Ghana a) Dr John Gyapong, Director of the Ghana Onchocerciasis Program, Ghana b) Research, training and development c) Government of Ghana d) Ghana, Canada e) 3 years E. CONSULTING ACTIVITIES (See also Appendix III)

Name: Roger Prichard Signature: Roger Prichard




Fort Dodge - 2 days

PARASOL - 2 days WHO-TDR – 2 days

Total : 2 days Total: 4 days Total: 6 days


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ACTIVITY REPORT FOR 2007 Name: Paula Ribeiro Date: August 11, 2008 A. RESEARCH AND SCHOLARLY ACTIVITY (Jan 1, 2007 – Dec 31, 2007) 1. Refereed Publications (names of trainees are underlined):

Nabhan, J., El-Shehabi, F., Patocka, N. and Ribeiro, P. (2007) The 26S proteasome in Schistosoma mansoni: Bioinformatics analysis, developmental expression and RNA interference (RNAi) studies Exp. Parasitol. 117: 337-347.

Patocka, N. and Ribeiro, P. (2007) Characterization of a serotonin transporter in the parasitic flatworm, Schistosoma mansoni: Cloning, expression and functional analysis. Molecular & Biochemical Parasitology 154: 125-133.

Dernovici, S., Starc, T. Dent, J. and Ribeiro, P. (2007) The serotonin receptor SER-1 (5HT2ce) contributes to the regulation of locomotion in Caenorhabditis elegans Developmental Neurobiology 67: 189-204

2. Conference / invited Presentations: • P. Ribeiro (2007) Properties of amine receptors in helminths. British Society for

Parasitology, Belfast UK. • P. Ribeiro (2006) Studies of a neglected parasite: Investigation of the cellular

proteasome in the human bloodfluke, Schistosoma mansoni. Genzyme Corporation, Boston MA. USA.

• Patocka, N. and Ribeiro, P. (2007). Serotonin receptors and transporter in Schistosoma mansoni: Their role in parasite survival 46th Annual Meeting of the Canadian Society of Zoologists, Montreal, Qc, Canada

• El-Shehabi, F. and Ribeiro, P. (2007) Characterization of SmGPCR and other histamine responsive GPCRs in Schistosoma mansoni 46th Annual Meeting of the Canadian Society of Zoologists, Montreal, Qc, Canada

• Taman, A.. and Ribeiro, P. (2007) Neurotransmitter Receptors in Schistosoma mansoni 46th Annual Meeting of the Canadian Society of Zoologists, Montreal, Qc, Canada

5. Grants Held: (PI marked in bold) Applicant Funding source/Title $ per year Years Ribeiro, P. and Dent. J FQRNT Center –New Initiatives Grant 28,000 07-08 Neuronal control of development in nematodes Ribeiro, P. NSERC Discovery Supplement Award 40,000 07-09 Molecular biology of helminths


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Ribeiro, P. NSERC Discovery Grant 50,000 07-11 Molecular biology of helminths

Spithill , T. et al FQRNT Center Grant 345,800 03-08

Center for Host Parasite Interactions 7. Editorial Work / Refereeing:

• “Ad Hoc” reviewing of manuscripts: International Journal for Parasitology, Journal of Neuroscience; Genetics; Neuropharmacology

• “Ad Hoc” reviewing of grants: NSERC • Member of the Editorial Board of the Canadian Journal of Zoology • Committee memberships: NSERC Steacie Fellowships Selection Committee

8. Other Scientific Activities:

Collaborations Ongoing collaborations with:

Dr. J. Dent, Department of Biology, McGill University Dr. T. Yoshino, University of Madison, US Dr. Michael Kimberley, Iowa State University, USA B. TEACHING AND GRADUATE STUDENTS SUPERVISION (June 1, 2006- May 31, 2007) 1,2. Courses Taught: Course # Duties Contact hrs enrolment (approx) Biotech Lab BTEC 620 Coordinator 35 hrs (lectures and labs) 20 Cell Biology AEBI 202 Coordinator 30 hrs (lectures) 90 Micro and MIMM 386 Project supervisor 12 hrs 60 Immunol Lab Teaching Evaluations: Question 10* Question 21** Biotech Lab BTEC 620 4.50 4.50 Cell Biology AEBI 202 4.0 3.5 Micro/ Immunol Lab MIMM 386 N/A N/A *#16 in Mercury ** #27 in Mercury N/A=not available 3. Supervision of HQP: a) Graduate Students graduated Laura Sayegh Degree: M.Sc. (Appl) Thesis Title: Neuronal Control of Development in Nematodes


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b) Graduate Students currently being supervised Fouad El-Shehabi Degree: Ph.D. Starting date: September 2002 Thesis Title: Properties of biogenic amine receptors in Schistosoma mansoni Funding: NSERC Nick Patocka Degree: Ph.D. Thesis Title: Identification of a monoamine transporter in Schistosoma mansoni Starting date: Jan 2005 (Transferred from M.Sc.) Funding; FQRNT scholarship Amira Taman Degree: Ph.D Project Title: Glutamate receptors in Schistosoma mansoni Starting date: January 2006 Funding: International scholarship c) Research Assistants / technicians Laura Sayeg Research Assistant 07 – to present C. ADMINISTRATIVE ACTIVITIES (June 1, 2007 – May 31, 2008) 1. Committees :

Departmental Curriculum Committee Chair Scholarships Committee Chair Departmental Safety Officer Biotechnology Committee committee member

Faculty Macdonald Faculty Committee Safety Committee Chair University Tenure Committee (FAES) committee member Graduate Program Review Committee (Ph.D.) committee member New Life Sciences major – Directly involved staff member University University Laboratory Safety Committee Macdonald representative NSERC Steacie Fellowships (internal selection committee) Member

D. INTERNATIONAL ACTIVITIES N/A E. CONSULTING ACTIVITIES N/A


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ACTIVITY REPORT FOR 2007-2008 Name: Reza Salavati Date: 7 July 2008 A. RESEARCH AND SCHOLARLY ACTIVITY (All of Section A with the exception of A.5. is for the period January 1, 2007 to December 31, 2007) 1. Publications a) Refereed Journals: b) Other Publications:

1. Salavati, R. (2007) Webct lecture notes for second section in Biochemistry I (FDSC 211)

2. Salavati, R. (2007) Webct lecture notes and laboratory manual for BTEC555 3. Salavati, R. (2007) Lecture notes for Experiments in biotechnology (AEBI 306)

2. Conference presentations and invited lectures 1. Salavati, R. RNA editing in trypanosomatid pathogens. Department of Biochemistry, McGill University. Jan 2007. 2. Salavati, R. RNA editing as a drug target in trypanosomatid pathogens. Department of Microbiology and Immunology, McGill University, Feb 2007. 3. Kala, S. and Salavati, R. KREPA4, an RNA binding protein essential for editosome integrity and survival in Trypanosoma brucei. Canadian Society of Zoologists. McGill University, May 2007. Poster presentation. 4. Shaneh, A. and Salavati, R. The sequence analysis of the RNA editing ligases in Trypanosoma brucei. Canadian Society of Zoologists. McGill University, May 2007. 5. Shateri Najafabadi, H. Salavati, R. Prediction of protein-protein interaction map based on genomic sequences. Poster presentation. Montreal Structural Biology meeting. Nov 2007. Poster presentation. 6. Shaneh, A. and Salavati, R. On acid-base complementarity in protein interaction networks. Robert-Cedergren Bioinformatics Colloquium, Udem, Nov 2007. 7. Shateri Najafabadi, H. Salavati, R. Protein interaction maps for Trypanosoma brucei and Trypanosoma cruzi: all for one, one for all, Poster presentation. Robert-Cedergren Bioinformatics Colloquium, Udem, Nov 2007. Poster presentation.


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3. Grants held - 3-yr. period: 2004-05; 2005-06; 2006-07 1. Structural and functional organization of the editosome in trypanosomatids Principal Investigator: Reza Salavati Granting agency: NSERC Type of Grant: Operating Amount of Grant: $173,730 Yearly installment: $34,746 Duration: from: 04/1/2006 to 03/31/2011 2. Structural organization of the editosome in trypanosomatids Principal Investigator: Reza Salavati Granting agency: CFI Leader opportunity fund Type of Grant: Infrastructure Amount of Grant: $375,000 Duration: from: 06/20/2006 to 06/30/2008 3. Structural organization of the editosome in trypanosomatids Principal Investigator: Reza Salavati Granting agency: CFI infrastructure operating fund 3 Type of Grant: Infrastructure and operating Amount of Grant: $30,000 Duration: from: 06/20/2006 to 06/30/2011 4. RNA as the catalyst for screening drugs against trypanosomatids Principal Investigator: Reza Salavati Granting agency: NIH Type of Grant: Operating Amount of Grant: $ 153,000 Duration: from: 06/30/2006 to 06/30/2007 5. Architecture of trypanosomatids KREPA control of editosome function Principal Investigator: Reza Salavati Granting agency: FQRNT CENTRE FOR HOST-PARASITE INTERACTIONS Type of Grant: New Initiatives Amount of Grant: $28,500 Duration: from: 04/1/2007 to 03/31/2009 4. Refereeing work Asked to review papers in International Journal of Parasitology


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B. TEACHING AND GRADUATE STUDENT SUPERVISION. 1. Courses taught and evidence of effectiveness a) BTEC555 structural Bioinformatics Overall, the instructor is a good teacher 4.6 Overall, this was a good course 4.3 b) PARA635 Cell Biology and infection Overall, the instructor is a good teacher 4.4 Overall, this was a good course 4.2 c) FDS211 Biochemistry I Overall, the instructor is a good teacher 4.4 Overall, this was a good course 4.2 2. List the names of students currently being supervised, the program and year of enrolment and the support paid to each student 1. Alireza Shaneh (Ph.D.) 2006: Characterization of RNA editing ligases in trypanosomes 2. Houtan Moshiri (M.Sc.) 2006: High throughput screening of chemical compounds against the editosome 3. Smriti Kala (Ph.D.) 2006: Characterization of KREPA4 in trypanosomes 4. Hamed Shateri Najafabadi (Ph.D.) 2007: Drug targets in trypanosomes C. ADMINISTRATIVE AND OTHER ACADEMIC ACTIVITIES 1. Committees - Department/Faculty/University Faculty IT committee member 2006-present Faculty Undergraduate recruitment committee member 2006-present Faculty McGill Centre for Bioinformatics Scholarship committee 2006-present Institute Fellowships Committee member 2007 Academic Advising- Graduate student examination committee Francois Fauteux (Ph.D.) Advisor: Dr. M. Stromvik


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Kei Chin Cheng (MSc) Advisor: Dr. M. Stromvik Normand Cyr (Ph.D.) Advisor: Dr. A. Jardim Lisa Purcell (Ph.D.) Advisor: Dr. T. Spithill Louis-Philippe Leroux (MSc) Advisor: Dr. F. Dzierszinski 2. External activities Co-supervisor for bioinformatics graduate students enrolled at the UdeM. Associate member in Department of Biochemistry, McGill University Member, McGill Centre for Bioinformatics


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McGill University, Faculty of Agricultural and Environmental Sciences and McGill School of Environment ACTIVITY REPORT FOR 2007-2008 NAME: Marilyn E. Scott DATE: June 16, 2008 A. RESEARCH AND SCHOLARLY ACTIVITY 1. Publications in Refereed Journals (January 1, 2007 to December 31, 2007)

Tu T, Koski KG, Wykes LJ, Scott ME. 2007. Re-feeding rapidly restores protection against Heligmosomoides bakeri (Nematoda) in protein deficient mice. Parasitology 134: 899-909. Gheorghiu C, Cable J, Marcogliese DJ, Scott ME. 2007. Effects of waterborne zinc on reproduction, survival and morphometrics of Gyrodactylus turnbulli (Monogenea) on guppies (Poecilia reticulata). International Journal for Parasitology 37: 375-381. Payne LG, Koski KG, Ortega-Barria E, Scott ME. 2007. Benefit of vitamin a supplementation on Ascaris reinfection is less evident in stunted children. Journal of Nutrition 137: 1455-1459. Bourgeois AC, Scott ME, Sabally K, Koski KG. 2007. Low dietary boron reduces parasite (Nematoda) survival and alters cytokine profiles but the infection modifies liver minerals in mice. Journal of Nutrition 137: 2080-2086. * Bourgeois AC, Koski K, Scott ME. 2007. Comparative sensitivity of feeding and non-feeding stages of Heligmosomoides polygyrus (Nematoda) to boron. Comparative Parasitology 74: 319-326. Tu T, Koski KG, Scott ME. 2007. Mechanisms underlying reduced expulsion of a murine nematode infection during protein deficiency. Parasitology 135: 81-93. … Scott ME. 2008. Ascaris lumbricoides: a review of its epidemiology and relationship to other infections. Annales Nestlé 66: 11-27. Randhawa HS, Saunders GW, Scott ME, Burt MDB. 2008. Redescription of Pseudanthobothrium hanseni Baer, 1956 and description of P. purtoni n. sp. (Cestoda: Tetraphyllidea) from different pairs of rajid skate hosts, with comments on the host-specificity of the genus in the northwest Atlantic. Systematic Parasitology 70: 41-60.


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Loaiza JR, Bermingham E, Scott ME, Rovira JR, Conn JE. Species composition and distribution of adult Anopheles (Diptera: Culicidae) in Panama. Journal of Medical Entomology (in press)

… Submitted … Tu T, Scott ME, Sabally K, Koski KG. Tissue mineral distributions are

differentially modified by dietary protein deficiency and a murine nematode infection. Biological Trace Element Research.

Tu T, Phillips AT, Koski KG, Scott ME. Acute phase nematode infection

reduces resting metabolic rate in both protein sufficient and protein deficient mice. Canadian Journal of Zoology.

2. Conference Presentations Scott ME. 2007. Field research on intestinal parasites in malnourished children

– is this type of project for you? First North American Congress of Parasitology, Merida, Mexico, 21-25 June. (INVITED PRESENTATION)

Gheorghiu C, Marcogliese DJ, Scott ME. 2007. Zinc toxicity in a fish-

ectoparasite system. Fourth Interdisciplinary Graduate Student Research Symposium, McGill University, Montreal, Canada.

Gheorghiu C, Marcogliese DJ, Scott ME. 2007. Zinc toxicity changes the

interactions in a fish-ectoparasite system. Canadian Society of Zoologists Annual Meeting, Montreal, Canada, May 21-25.

Odiere M, Bayoh MB, Gimnig J, Vulule J, Irungu L, Walker E. 2007. Utility of

claypots as a sampling tool and their potential as a control tool for malaria vectors (Anopheles gambiae s.l.). Canadian Society of Zoologists Annual Meeting, Montreal, Canada, May 21-25.

Tu T, Koski K, Scott ME. 2007. Leptin concentrations and delayed expulsion

of a mouse nematode. Canadian Society of Zoologists Annual Meeting, Montreal, Canada, May 21-25.

Koski KG, Bourgeois AC, Scott ME. 2007. Dietary boron deprivation reduces

Heligmosomoides bakeri (Nematoda) survival and alters cytokine profile but infection modifies liver minerals in mice. FASEB Experimental Biology Meeting (American Society of Nutrition), Washington, April 28-May 2. FASEB J 21, A244.3

….


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Diawara A, Halpenny C, Scott ME, Prichard RK. 2008. Assays to detect

benzimidazole-resistance SNPs in soil transmitted helminths. Centre for Host Parasite Interactions Annual Meeting, June.

Gheorghiu C, Marcogliese DJ, Scott ME. 2008. Zinc toxicity in a fish-

ectoparasite system. Fisheries Society of the British Isles International Symposium, Cardiff, Wales, July 21-25.

3. Postdoctoral Fellows and Visitors Kebba Sabally, Research Associate 4. Organization of Advanced Seminars 5. Grants Held

NSERC Research Grant, “Host-Parasite Population Dynamics”, renewed for $44,850 pa for five years (2007-2012) NSERC Special Research Opportunity Grant (Fussmann, Scott, Hendry, Bentzen), “Ecology and Evolution of Parasite-Host Relationships in a Real Ecosystem”; $141,400, $127,700, $82,760 (2008-2011) SENACYT Science Against Poverty Grant from Panama (Valdez, Scott, de Arias, Calvo), Investigación científica integral sobre el impacto de los programas de transferencia condicionada en el ciclo de pobreza, $50,000 US (in total) (2008-2011) SENACTY International Collaboration Grant from Panama (Murillo, Scott, Koski, Sinisterra); Consumo de Café y Suplementos de Hierro: Sus Roles e Interacciones Sobre la Anemia Ferropriva, la Baja Talla para Edad y los Niveles de Infección Gastro-Intestinales en Niños Indígenas de la Comarca Ngöbe Buglé de Panamá; $90,000 US (in total) (2008-2011) SENACYT International Collaboration Grant from Panama (Sanjur, Conn, Scott, Rovira); Estado taxonómico, estructura genética y historia demográfica del vector de malaria Anopheles punctimacula en Panamá basado en análisis de ADN mitocondrial y nuclear; $70,000 US (in total) (2008-2011) McGill School of Environment New Initiatives (Scott, Fussmann, Hendry); “Host-Parasite Evolution and Ecosystem Dynamics during a Controlled Invasion Event”; $2000 (2007-2008)


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NSERC Research Tools and Instruments Grant (Wykes, Koski and Scott) Bioplex system for multiplexing microassays of biomarkers. $66,844 (2007-2008) FQRNT New Initiatives Grant (Scott, Koski, Ortega, Ndar, Ward, Urban), “Multiple Infections and Multiple Nutritional Deficiencies: A Challenge for Innovative Approaches to Parasite Control”, $30,400 pa (2006-2008) RRSPQ Réseau de recherche en santé des populations du Québec. (Scott, Koski). Adaptive ecohealth approach to evaluating a comprehensive health and education intervention. $5000 (2007) McGill-Panama Consortium Funding from McGill’s VP Research, Deans of Science, Arts, Agricultural and Environmental Sciences, and from Laval University and UQAM; (Potvin, Scott, Koski, Blanchette, McGill); $43,000 pa (2006-2008)

6. Honors and Awards 7. Refereeing and Editorial work Editorial Board of Parasitology Editorial Consultant for Journal of Parasitology Associate Editor for Ecoscience Ad hoc reviews for the following journals: Annals of Tropical Medicine and Parasitology 1 Clinical Nutrition 1 Infection and Immunity 1 Functional Ecology 1 Ecology 1 Journal of Nutrition 1 Grant reviews: Grant Agency of the Academy of Sciences of the Czech Republic (1) Wellcome Trust (1) NSERC Discovery Grants (2) 8. Other scientific activities Scott ME. 2007. Concurrent Infections – A Plea for More Research.

Symposium Celebrating the 75th Anniversary of the Institute of Parasitology, McGill University. August 10, 2007.

Scott ME. 2007. Creating graduate programs that transcend disciplines. Invited presentation. Beyond Borders: Building Interdisciplinary Research and Education in Global Health and Social Policy Conference, Montreal, May 17.


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B. TEACHING AND GRADUATE STUDENT SUPERVISION 1. Courses Taught

Mathematical Methods in Ecology; 17 students; Overall, the instructor is a good teacher. 4.6 Overall, this was a good course. 4.4 Environment and Infection; 24 students (plus 1 registered as graduate student) Overall, the instructor is a good teacher. 4.9 Overall, this is a good course. 4.6 Guest Lectures AGRI 411 International Agriculture (2 hrs) WILD 205 Principles of Ecology (1 hr) AGRI 195 Freshman Seminar (1 hr) NUTR 620 Nutrition of Indigenous Peoples (3 hr) PARA 655 Host-Parasite Interactions (7.5 hrs ; 11 students) Overall, the instructor is a good teacher. 4.8

2. Undergraduate Projects Summer Students (2007-2008) Valerie Hongoh (MSE; NSERC Summer Student; 2007) Dorian Irwin Kristmanson (Nutrition; 2007) Shahab Khademi (Nutrition; 2007) Lauren Kay (Physiology; NSERC Summer Student; 2008) Honours Students (2007-2008) Valerie Hongoh (MSE) Project Students (2007-2008) Julie Menard (NRS) Alastair Dorreen (MSE Diploma Student) 3. Graduate student supervision

Current Students

Tao Tu, Ph.D. 7 (co-supervisor with Koski); registered 2000 (on maternity leave from January – June 2005); thesis submitted May 2008 Jose Loaiza, Ph.D. 4; registered September 2005; SENACYT

Scholarship


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Carli Halpenny, PhD3; registered September 2006; NSERC Scholarship

Maurice Odiere, PhD3; registered September 2006; Rotary International Scholarship

Marie-Pierre Lardeau, MSc2: registered September 2006 in joint ad

personam degree between School of Dietetics and Human Nutrition and Institute of Parasitology

Dorian Irwin Kristmanson (co-supervisor with Koski); MSc1;

registered September 2007 (School of Dietetics and Human Nutrition)

Candice Scatliff (Baker); MSc1; registered January 2008 (School of

Dietetics and Human Nutrition); NSERC Scholarship

4. External Examiner Internal Examiner Catherine Bourguinat (PhD Oral Committee Member) C. ADMINISTRATIVE AND OTHER ACADEMIC ACTIVITIES 1. Committees

Institute of Parasitology Member, Fellowships Committee Member, Curriculum Committee Member, Admissions Committee Member, Search Committee for Junior Position

Faculty

Mentor for Junior Faculty Member, Working Group on Teaching Excellence Member, Work Team for International Development Major

McGill School of Environment

Chair, Graduate Affairs Committee Chair, Environment Option Committee Member, Council

University

Director, Quebec-Panama Consortium Affiliate Member, Centre for University Teaching and Learning


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Associate Member, School of Dietetics and Human Nutrition Associate Member, Department of Natural Resource Sciences Member, University Tenure Committee for Faculty of Engineering Member, McGill Working Group on the Environment

2. Academic Advising 3. External Activities Appointed to NSERC Grant Selection Committee: “Healthy Environment and

Ecosystems” target area for the Strategic Project Grants Competition; May 2008 4. Administrative Appointments Associate Director for Graduate Student Affairs, McGill School of Environment

5. Other Professional Activities

D. INTERNATIONAL ACTIVITIES

Project Director: Marilyn Scott with Kristine Koski, Victoria Valdez, Enrique Murillo, Teresita de Arias, Odalis Sinisterra, Arlene Calvo, Oris Sanjur, Jan Conn, José Rovira

Nature of Activity: Nutrition-infection interactions; vector biology Source of Funding: McGill Seed Funding, RRSPQ, SENACYT Partner Country: Panama Project Duration: 3 years

E. CONSULTING ACTIVITIES Name : __Marilyn E. Scott_______ Signature : Marilyn E. Scott




Manuscript Review 2 days

Grant Review 4 days

Total : Total: 6 days Total:


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ACTIVITY REPORT FOR 2007-2008 Name: Terence W. Spithill Date: 3 August 2008 A. RESEARCH AND SCHOLARLY ACTIVITY

(All of Section A with the exception of A.5. is completed for the period January 1, 2007 to December 31, 2007.

a) Publications in Refereed Journals

Raadsma, H.W., Kingsford, N.M., Suharyanta, SPITHILL, T.W. and Piedrafita. D. Host responses during experimental infection with Fasciola gigantica or Fasciola hepatica in Merino sheep I. Comparative immunological and plasma biochemical changes during early infection. Vet Parasitol. 143: 275-286 (2007). Piedrafita,D.M., Estuningsih, E., Pleasance, J., Prowse, R.K., Raadsma,H.W., Meeusen, E.N.T. and T.W. SPITHILL. Peritoneal lavage cells of Indonesian thin tail sheep mediate antibody-dependent superoxide radical cytotoxicity in vitro against newly excysted juvenile Fasciola gigantica but not juvenile Fasciola hepatica. Inf. Immunity 75:1954-1963. (2007). Yanow, S.K., Purcell, L.A., Lee, M., Spithill, T.W. Genomics-based drug design targets the AT-rich malaria parasite: implications for anti-parasite chemotherapy. Pharmacogenomics 8: 1267-1272 (2007).

2. Conference Presentations and Invited Lectures

International: SPITHILL, T.W., Estuningsih,E., Pleasance, J., Prowse, R., Raadsma, H.W., Meeusen, E.N.T., and Piedrafita, D. 2007. “Antibody-dependent superoxide-mediated killing of juvenile Fasciola gigantica but not F. hepatica by macrophages and eosinophils of Indonesian thin tail sheep”. British Society for Parasitology Annual Meeting, Belfast, April. Rioux, M.C., Carmona, C., Acosta, D., Gibbs, B., Bennett, H., Ward, B., Ndao, M., SPITHILL, T.W. 2007. “Serum biomarkers of fasciolosis in sheep: insights into host-parasite interactions”. World Association for the Advancement of Veterinary Parasitology, Gent, August. SPITHILL, T.W., Estuningsih, E., Pleasance, J., Prowse, R., Raadsma, H., Meeusen, E., Piedrafita, D. 2007. “Newly excysted juveniles of F. hepatica and F. gigantica differ in susceptibility to immune effector mechanisms in vitro: Implications for control of fasciolosis”; Invited speaker , American Society for Tropical Medicine and Hygiene Annual Meeting, Philadelphia, November. Purcell, L.A., Yanow, S.K., Pradel, G., Rodriguez, A., Lee, M., SPITHILL, T.W. 2007. “Developmental arrest of malaria parasites in mosquitoes following treatment of mice with AS-I-145”. American Society for Tropical Medicine and Hygiene Annual Meeting, Philadelphia, November.


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Yanow, S.K., Purcell, L.A., Rodriguez, A., Lee, M., SPITHILL, T.W. Potent Antimalarial Activity of the A/T-specific Alkylating Agent AS-I-145 Against Plasmodium in vitro and in vivo. American Society for Tropical Medicine and Hygiene Annual Meeting, Philadelphia, Nov 2007. National: Rioux, M-C., Carmona, C., Acosta, D., Gibbs, B., Bennett, H., Ward, B.J., Ndao, M., SPITHILL,T.W. (2007). Serum biomarkers of Fasciola hepatica infection in sheep. Canadian Society of Zoologists Annual Meeting, Montreal, May. Purcell, L., Yanow, S.K., Pradel., G., Rodriguez, A., Lee, M., and SPITHILL, T.W. 2007. The transmission blocking activities of a potent new antimalarial. Canadian Society of Zoologists Annual Meeting, Montreal, May. 3. Supervision of and Collaboration with Postdoctoral Fellows and Other Visitors Dr Janelle Wright, PDF, studying Fasciola biochemistry. Dr Ibtisam Goreish, Central Veterinary Research Laboratories (CVRL), Khartoum, Sudan. Mr Pramote Sriwanitchrak, Thammasat University, Thailand Ms Manussabhorn Sethadavit, Mahidol University, Thailand. 4. Organization and participation in advanced seminars (beyond regular teaching

assignments) Seventh Quebec Parasitology Symposium, FQRNT Centre for Host-Parasite Interactions: held at McGill with Canadian Society of Zoologists. 5. Grants Held - 3-yr. period: 2005-06; 2006-7; 2007-8. 2005-2006 “Functional characterisation of the immunomodulatory activities of cathepsin proteases and ES molecules released by Fasciola hepatica”. $54,800 pa. NSERC. “Canada Research Chair in Immunoparasitology”. $200,000 pa. Canada Research Chair Program. “Centre for Host-Parasite Interactions”. Regroupements Stratégiques Centre grant. PI-Spithill along with 20 others from across Quebec. $345,800 pa for 2003-2009. FQRNT, Government of Quebec. Spithill is the PI. “SELDI-ToF MS in blood-borne protozoan infections: novel diagnostic approach and new insights into host-parasite interactions”. $194,100 pa CIHR. 2004-2006. B. Ward (PI), T. Spithill, G. Matlashewski, M. Ndao, A. Kirk.


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“SELDI-ToF MS in protozoan infections: Protecting the Canadian blood supply” $150,350 pa 2004-2005. CIHR. B. Ward (PI), T. Spithill, M. Ndao, G. Matlashewski. “Identification of serum biomarkers associated with resistance/susceptibility to malaria infections in humans”. $30,400 FQRNT Centre New Initiatives Grant. 2005-2007. T. Spithill (PI), T. Geary, B. Ward, M. Ndao, M. Troye-Blomberg, A. Dolo, O. Doumbo 2006-2007 “Proteomic approach to characterisation of pathogenesis mechanisms in fasciolosis” $55,900 pa. renewed NSERC. “Canada Research Chair in Immunoparasitology”. $200,000 pa. Canada Research Chair Program. “Centre for Host-Parasite Interactions”. Regroupements Stratégiques Centre grant. PI-Spithill along with 20 others from across Quebec. $345,800 pa for 2003-2009. FQRNT, Government of Quebec. Spithill is the PI. “SELDI-ToF MS in blood-borne protozoan infections: novel diagnostic approach and new insights into host-parasite interactions”. $194,100 pa CIHR. 2004-2006. B. Ward (PI), T. Spithill, G. Matlashewski, M. Ndao, A. Kirk. “Identification of serum biomarkers associated with resistance/susceptibility to malaria infections in humans”. $30,400 FQRNT Centre New Initiatives Grant. 2005-2007. T. Spithill (PI), T. Geary, B. Ward, M. Ndao, M. Troye-Blomberg, A. Dolo, O. Doumbo, C. Mackenzie. 2007-8 “Proteomic approach to characterisation of pathogenesis mechanisms in fasciolosis.” $55,900 pa. renewed NSERC. “Canada Research Chair in Immunoparasitology”. $200,000 pa. Canada Research Chair Program. “Centre for Host-Parasite Interactions”. Regroupements Stratégiques Centre grant. PI-Spithill along with 20 others from across Quebec. $345,800 pa for 2003-2009. FQRNT, Government of Quebec. Spithill is the PI. “Identification of serum biomarkers associated with resistance/susceptibility to malaria infections in humans”. $30,400 FQRNT Centre New Initiatives Grant. 2005-2007. T. Spithill (PI), T. Geary, B. Ward, M. Ndao, M. Troye-Blomberg, A. Dolo, O. Doumbo, C. Mackenzie. “SELDI-TOF for protozoan parasites-protecting the Canadian Blood supply”. $209,000 pa. CIHR. 2007-2009. B. Ward (PI), M. Ndao, G. Matlashewski, M. Gottschalk, T.W. Spithill.


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6. Honours and Awards Received President elect, Australian Society for Parasitology. 2008-2010 7. Refereeing and Editorial Work Member of Editorial Board, Parasite Immunology Editorial Advisor, PLoS Journal of Neglected Tropical Diseases; Ad hoc reviewer for several Journals: Parasite Immunology, International J for Parasitology, Infection and Immunity, Molecular and Biochemical Parasitology, Mol Cell Biochemistry, Exp Parasitology. Reviewer for granting agencies: CFI New Opportunities program; Canada Research Chair Program; NSERC; member, CIHR University-Industry Committee; Wellcome Trust, UK; Australian Research Council. 8. Other Scientific Activities B. TEACHING AND GRADUATE STUDENT SUPERVISION (June 1, 2007 - May 31, 2008) 1. Courses Taught and Evidence of Effectiveness I taught the course PARA-655, Host-Parasite Interactions (Sept-Dec 2007). 2. List names of students who have completed their theses under my supervision, the duration of that supervision, title of thesis, papers, even if not joint, which may have resulted from the thesis and present location of the student: Lisa Purcell, 2004-2007: “Genetic and biochemical strategies to block the transmission cycle of the malaria parasite”.

1. Yanow, S.K., Purcell, L.A. and Spithill, T.W. The A/T-specific DNA alkylating agent Adozelesin inhibits P. falciparum growth in vitro and protects mice against P. chabaudi infection. Mol Biochem Parasitol. 148: 52-59 (2006).

2. Yanow, S.K., Purcell, L.A., Lee, M., Spithill, T.W. Genomics-based drug design targets

the AT-rich malaria parasite: implications for anti-parasite chemotherapy. Pharmacogenomics 8: 1267-1272 (2007).

3. Yanow, S.K*., Purcell, L.A*., Pradel, G., Sato, A., Rodriguez, A., Lee, M., Spithill,

T.W. Potent antimalarial and transmission-blocking activities of a novel DNA binding agent. J Inf Diseases 197:527–534 (2008).* joint first author.


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4. Purcell, L.A., Yanow, S.K., Lee, M., Spithill,T.W. and Rodriguez, A. Chemical attenuation of Plasmodium berghei sporozoites induces sterile immunity in mice. Inf Immunity 76:1193-9 (2008).

5. Purcell, L.A., Wong, K.A., Yanow, S.K., Lee,M., Spithill, T.W. and A. Rodriguez.

Chemically attenuated Plasmodium sporozoites induce specific immune responses, sterile immunity and cross-protection against heterologous challenge. Vaccine (in press 2008). Currently postdoctoral fellow, Columbia University, New York.

List the names of students currently being supervised, the program and year of enrolment and the support paid to each student:

PhD students Marie-Claire Rioux, Institute of Parasitology, McGill, 2005-present, “Biomarkers for fasciolosis”. $19,000 pa. from NSERC grant. Postdoctoral fellows Janelle Wright, Institute of Parasitology, McGill, 2007-present, “Biomarkers of parasite infection” $35,000 pa from NSERC grant. C. ADMINISTRATIVE AND OTHER ACADEMIC ACTIVITIES (June 1, 2007 - May 31, 2008) 1. Committees 2. Advising Letters of reference for: Lisa Purcell. 3. External Activities

Invited Lecturer “Advances in Modern Biotechnology and Molecular Techniques in Veterinary Parasitology: Diagnosis, Chemotherapy and Control", 17-21March 2008, Alagappa University, Tamil Nadu, India. External Consultant, External expert, EU DeLiver Project, Annual Meeting, April 2008, Sofia, Bulgaria.

4. Administrative Appointments

5. Other Professional Activities


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D. INTERNATIONAL ACTIVITIES (June 1, 2007 – May 31, 2008) International projects and/or activities involving international collaboration: Invited Lecturer “Advances in Modern Biotechnology and Molecular Techniques in Veterinary Parasitology: Diagnosis, Chemotherapy and Control", 17-21March 2008, Alagappa University, Tamil Nadu, India. External Consultant, External expert, EU DeLiver Project, Annual Meeting, April 2008, Sofia, Bulgaria. Prof P Sobhon, Mahidol University, Thailand PhD training, Manussabhorn Sethadavit Thai Government, $7,000 Thailand. Dr David Artis, U. Pennsylvania, 2006-present Studying biomarkers of T. muris infection in mice. Dr Rudi Grams, Thammasat University, Thailand, 2006-present Expressing F. gigantica vaccine proteins. PhD training, Mr Pramote Sriwanitchrak, Thammasat University, Thailand, 2007 Studying biomarkers of human cholangiocarcinoma. Dr Carlos Carmona, Universidad de la República Oriental del Uruguay, Uruguay, 2006-present. Studying biomarkers for Fasciola infection in sheep. Dr Moses Lee, Hope College, USA, 2006-present Studying new chemotherapies for malaria. Dr Ana Rodriguez, NYU, USA, 2006-2008 Studying new chemotherapies for malaria and gametocyte biology. Dr David Piedrafita, Monash University, Australia, 2006-2008 New diagnostics for Fasciola and vaccine studies. Dr Herman Raadsma, University of Sydney, Australia, 2006-2008 Biology of Fasciola in sheep. Dr Rob Pike, Monash University, Australia, 2006-2008 Cathepsin B of Fasciola. E. CONSULTING (for the period June 1, 2007 – May 31, 2008) 4 days reviewing for journals 5 days for CFI, CIHR reviews 2 days for PhD thesis reviews 11 days total

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