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Int. J. of Medical Engineering and Informatics > 2012 Vol.4, No.1 > pp.25 - 35

Title: T-cell receptor variable beta (1-24) gene repertoire in patients with Wuchereria

bancrofti infections

Author: M.S. Sudhakar; K.V. Alala Sundaram; R.B. Narayanan

Address: Centre for Biotechnology, Anna University, Chennai 600 025, India. ' Department

of Plastic Surgery, Royapettah General Hospital, Chennai 600 014, India. ' Centre for

Biotechnology, Anna University, Chennai-600 025, India

Journal: Int. J. of Medical Engineering and Informatics, 2012 Vol.4, No.1, pp.25 - 35

Abstract: T-cell receptor V beta (TCRVβ) gene repertoire (Vβ1-Vβ24) was evaluated in the

peripheral blood mononuclear cells (PBMCs) from asymptomatic and amicrofilaremic

normal individuals (EN), and patients with chronic pathology (CP) harbouring Wuchereria

bancrofti. TCRVβ gene expression in phytohemagglutinin (PHA) stimulated PBMC cultures

from EN and CP individuals was in the order EN > CP while in Brugia malayi adult antigen

(BmA) or purified protein derivative from mycobacterium tuberculosis (PPD) stimulation or

the unstimulated conditions, the order was CP > EN. Thus, the PBMCs of the CP patients

showed elevated levels of TCRVβ gene expression both in the unstimulated and stimulated

conditions compared to EN.

Keywords: filariasis; T-cell receptor V beta; TCRV-beta; purified protein derivatives; PPD;

Brugia malayi adult antigen; BmA; Wuchereria bancrofti; gene expression;

phytohemagglutinin; PHA; peripheral blood cells; blood mononuclear cells; mycobacterium

tuberculosis; mycobacterium TB.

DOI: 10.1504/IJMEI.2012.045301

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Resource Secured

T–cell receptor variable beta (1–24) gene

repertoire in patients with Wuchereria

bancrofti infections Journal International Journal of

Medical Engineering and

Informatics

Publisher Inderscience Publishers

ISSN 1755-0653 (Print)

1755-0661 (Online)

Subject Biosciences and

Bioinformatics, Computing

Science, Applications and

Software and Healthcare and

Medical Engineering

Issue Volume 4, Number 1/2012

Pages 25-35

DOI 10.1504/IJMEI.2012.045301

Subject Group Computing and

Mathematics

Online Date Monday, February 06, 2012