Introduction to Bruker Optics,Introduction to Bruker Optics,NSC Mid Year Sales Meeting Sept 2007,NSC Mid Year Sales Meeting Sept 2007,

By Muhammad SaeedBy Muhammad Saeed

Bruker Optics

• offers the complete product line

• is leading in technology and innovations

• is steadily growing

• is the only European supplier

• is world wide present

FT-IR FT-NIR Raman Terahertz TD-NMR

Our products are based on

molecular spectroscopy

Founded in 1960 in Germany

Bruker world wide today :

> 3000 Employees

> 25 Locations

> 50 Sales and Service Offices

> 700 Mio. $ Revenue

Bruker Group

Bruker Group

X - Ray Fluorescence and Diffraction

Mass Spectrometry

NMR-Spectrometry

Optical Spectroscopy

Company Technology

Process Monitoring Laboratory Analysis Research & Development

Bruker Optics - we offer solutions

Life Science Academics Quality Control

Bruker Optics product line

Bruker is the only supplier with a complete product line

TENSOR 27/37FT-IR

Spectrometer

VERTEX 70/80FT-IR

Spectrometer

IFS 125FT-IR

Spectrometer

1.) Basic IR up to highest resolution spectrometer.

World record: The IFS 125 HR is the spectrometer with the highest resolution in the marketWorld record: The Alpha is world’s smallest FTIR Spectrometer.

ALPHAFT-IR

Spectrometer

Bruker Optics product line

2.) Microscopy

-Sample compartment microscope

-IR microscope

ImagingHYPERIONHELIOS

-IR imaging microscope

-Raman microscope

Bruker is the only supplier with a complete product line

Bruker Optics product line

3.) Near IR spectrometer

-Lab QA/QC

-Process

MPA MATRIX Industry

Bruker is the only supplier with a complete product line

Bruker Optics product line

4.) Complete Raman product line

FT-Raman module

FT-Raman spectrometer

Dispersive Raman process

Dispersive Raman microscope

Bruker is the only supplier with a complete product line

RAM II RFS 100 SENTINEL

Bruker Optics product line

5.) Plus

Minispec

TeraHertz

Spectrographs

Bruker is the only supplier with a complete product line

minispec TeraView Spectrographs

Bruker Optics product line

Bruker is the only supplier with a complete product line

6.) Solutions for dedicated markets:

- Process

PAT Food Polymer

Bruker Optics product line

Bruker is the only supplier with a complete product line

6.) Solutions for dedicated markets:

- Life Science

Proteomics Microbiology Tissue

Bruker OpticsIntroduction to FT-IR spectroscopyIntroduction to FT-IR spectroscopyIntroduction to FT-IR spectroscopyIntroduction to FT-IR spectroscopy

Bruker Optics

In the year 1800 the astronomer Friedrich Wilhelm Herschel analyzed the spectrum of sunlight. Herschel created the spectrum by directing sunlight through a glass prism so that the light was divided into its different colors. He measured the heating ability of each color using thermometers with blackened bulbs. When he measured the temperature just beyond the red part of the spectrum he noticed some kind of invisible radiation. Much to his surprise he found that the area close to the red part (i.e. an area apparently devoid of sunlight) had the highest heating ability of all. Herschel concluded that there must be a different kind of light beyond the red portion of the spectrum, which is not visible to the human eye. This kind of light became known as “infrared” (below red) light.

Herschel then placed a water-filled container between the prism and thermometer and observed that the temperature measured was lower than the one measured without the water. Consequently, the water must partially absorb the radiation. In addition, Herschel could prove that depending on how the prism was rotated (i.e. depending on the spectral range) the difference in the temperatures measured for each color varied. This was the beginning of infrared spectroscopy.

Infrared spectroscopy measures the infrared light that is absorbed by a substance. This absorption depends on the wavelength of the light.

Friedrich Wilhelm Herschel(1738 - 1822)

Discovery of infrared light

Visible light and infrared light are two types of electromagnetic radiation, but with different wavelengths, or frequencies. In general, electromagnetic radiation is defined by the wavelength or the linear frequency . The wavelength is the distance between two maxima on a sinusoidal wave.

The frequency is the number of wavelengths per unit time. Since all electromagnetic waves travel at the speed of light, the frequency corresponding to a given wavelength can be calculated as:

= c/

According to the Plank’s Radiation Law, the frequency of electromagnetic radiation is proportional to its energy.

E = h•

In infrared spectroscopy wavenumber is used to describe the electromagnetic radiation. Wavenumber is the number of wavelengths per unit distance. For a wavelength in microns, the wavenumber, , in cm-1, is given by

= 10000/

The electromagnetic spectrum

Sinusoidal wave of wavelength ~

~

The electromagnetic spectrum

The electromagnetic spectrum

The electromagnetic spectrum

The electromagnetic spectrum

Interaction of radiation and matterIf matter is exposed to electromagnetic radiation, e.g. infrared light, the radiation can be absorbed, transmitted, reflected, scattered or undergo photoluminescence. Photoluminescence is a term used to designate a number of effects, including fluorescence, phosphorescence, and Raman scattering.

Incident light beam Incident light beam

Reflection

Matter

Photoluminescence

Scattering

TransmissionAbsorptionAbsorption

Interaction of radiation and matter

15,000 cm-1 4,000 cm-1 400 cm-1 5 cm-1

NIRNIR MIRMIR FIRFIR

Separation of spectral ranges

Infrared light emitted from a source (e.g. a SiC glower) is directed into an interferometer, which modulates the light. After the interferometer the light passes through the sample compartment (and also the sample) and is then focused onto the detector. The signal measured by the detector is called the interferogram.

General FT-IR spectrometer layout

The working principle of an FT-IR spectrometer

FT-NIR Spectrometer

MPA - Multi Purpose Analyzer

MATRIX-I: Process Analysis in Diffuse Reflection

FT-NIR Spectrometer

Qualification of Raw Materials

• Disinfecting Materials

• Detergents

• Aromas

• Milk Powder (liquid Milk)

• Thickening Agents

• Starches

• ....

NIR Spectroscopy in the Food Industry

• Sugar Content in Water/juices

• Pure Yolk/Alcohol Content in Egg Liquor

• Moisture Content/Total Sugar in Marzipan

• Fat/Protein/Water/Mineral Salt in Sausages

• Fat/Water/Protein/sugar in Mayonnaise or in Chocolate

• Fat/Dry Matter in Ice Cream

• Caffeine in Black Tea

• Caffeine in Instant Coffee

• Bloom-Number in Gelatine

• Trans Fatty Acids in Edible Oils (MIR)

• Moisture/Protein/Starch/Ash/Raw Fiber in Cereals

• Moisture/Nicotine in Tobacco

• ....

Quantification of Ingredients

NIR Spectroscopy in the Food Industry

• Additives (Antioxidants, Lubricants, Modifiers, ...)

• Filler• physical Properties

(Density, Viscosity, ...)• averaged Molecular Weight• MFI (Melt Flow Index) • Humidity• Content of Carboxyl End Groups• OH-Number• Acid Number• Monomer Content...

Applications

NIR IN Polymer Chemistry

• Stabilizer Content• Content of Rest Monomer• Density• Viscosity• MIBK (Methyl-Isobutyl-Ketone)• WPE (Weight per Epoxy)• MBCI (Poly(Etherurethane)Diisocyanate)• Content of Total PE, PEP, PEEP and

Block-Co-Polymer

...

NIR in Polymer Chemistry

• Octane Number (RON & MON)

• Flash Point

• Cloud Point

• Boiling Behavior

• Cooling Behavior

• Content of Aromates

...

NIR Applications In Petrochemistry

NIR Applications of Pharmaceuticals

• Identification in the Receipt of Goods• Quantification of

– active Materials– auxiliary Materials– Filler

in Powders, Capsules, Tablets or Phials• Water Content in Powders• Surveillance of Drying Processes• Mixing• Solvent Recovery• Placebo/Verum Studies• Wall Thickness of Capsules• physical Properties (Hardness,

Brittleness, … )

NIR Application in Feed and Feed ingredients

The Feed and Feed Ingredients calibrations include feed for various animals like ruminant, poultry, swine, horse and fish, as well as feed ingredients like seeds, cereals, legumes, roughage and animal by-products.

Feed and Feed Ingredients

Min % Max % R n Origin2

Moisture 2.1 21,6 0,952 36.000+ UK & Ireland, EU, USA,

Oil 0.1 61.6 0.998 27.000+ Australia, SE Asia,

Protein 1.7 61.7 0.994 39.000+ Pakistan, India, China,

Fiber 0.1 36.5 0.974 15.000+ J apan, Malaysia,

Ash 0.7 59.4 0.962 22.000+ Peru, Argentina, Brazil

Starch 0.1 77.5 0.988 6.000+

• Fast (10 - 20 sec. typical)

• No sample preparation, simple to operate

• No waste, no pollution

• Simultaneous determination of multiple

components per measurement

• Highly precise and accurate

• Measure through packaging

• Transferable methods

• Real time monitoring for process

Advantages

NIR

NIR

NIR (MPA) Advantages

Summary

• Very often the time consumption for the method development is for HPLC and GC higher than NIR

• The NIR analysis time is generally much faster.

• Mostly installation and maintenance-costs for in-line- & off-line application is much lower for NIR.

• NIR = cost effective!

Competition

Bruker Optics

Competition

FOSS = giant

Founded in 1956, >50 years exper.

1100 employees for Agri applications worldwide, 300 service & appl. staff

Present in 21 countries

Perfect marketing and market knowledge

100++ distributors

Created “agri” standards

Competition

FOSS:

6500/5000 will die in 2007

Still problems with InfraXact

Old fashioned XDS is promoted:

„XDS is the latest & outstanding technology. In the past only the high priced Pharma customers have had access. Now it is available for everybody.“

FOSS is getting more aggressive also in pricing

FOSS is in trouble – use it now!

Bruker Optics

Competition

THERMO:

Currently very active!

Focus on Pharma/PAT

Attacks classical BRUKER markets (non-agri)

Still relatively weak in NIR, but THERMO is a “sleeping shark”

Competition

THERMO Strategy:

Offering full options at low price

Engineering is weak

Our answer:

You need to know our USPs adapted to the customers needs

Demonstrate the value of MPA for the dedicated customer application

NIR: Quality beats price!

Competition

BÜCHI:

Focus on Agri and Grain

Cross selling

Active in limited number of countries (now

+US)

ABB:

Focus on Process and Dairy

Strong in Petro & all kind of OEMs

Strategy for the Key Markets

Strategy for Chemistry Applications

• Endless number of applications are possible: OH, acid number, QA/QC, in-line & off-line

• High benefits of NIR by replacing HPLC

• MPA = blockbuster

• Our sales structure fits perfectly to this market (solving applications on site)

• Bio fuels are coming!

Strategy for Polymer Applications

•Most Key Accounts are still OPEN like SABIC.

•Biggest margins could be earn by developing applications.

Strategy for Pharma Applications

• All world’s biggest companies are using Bruker’s MPA.

• Pharma could be best future prospective.

• Applications:

STILL: raw ID & tablet testing (by MPA)

Strategy for PetroChemistry Applications

•Saudi ARAMCO could be big customer and we can make good margin.

•Need to work very closly.

•NSC already involved and have done applications.

Strategy for F & F (Food & Agri) Applications

•The market still OPEN.

•Big Companies(Provimi,

Degussa, Addiseo, Nestlé, …) now

using Bruker’s systems which

could be useful for F&F business

in KSA.

•The Dairy Companies still using

old techniques which is good

news for us.

•Markets are ready for us. We are

highly welcome!!

To Do List

Bruker = Market Leader

We create the standards

(in non-agri)

Others will copy our success:

Save your market shares

Diversify – put not all eggs in one basket

To Do List

Put more efforts in the chemical market

Promote INGOT

Communicate (via M.Saeed) – Knowledge & expertise is getting more and more important

Do not hesitate to ask for support

One final remark about the future SM

www.brukeroptics.com

Thank you very much!