introduction to the immune system - kaudr. mohamed farouk elshal immunity • immunity – the...
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Dr. Mohamed Farouk Elshal
Introduction to The ImmuneSystem
• Mohamed Farouk Elshal, Ph.D.Bldg.: 71 / Room:2008;[email protected]
References:1. Abbas, A, K. et.al, Cellular and MolecularImmunology, 6th ed., 20072. Male D., J. Brostoff, D. B Roth, and I. RoittImmunology, 7th ed., 2006.
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Dr. Mohamed Farouk Elshal
Keys toward Learning Immunology
• Lectures => Deliver the key concepts ofImmunology.
• Workbook => Apply the knowledge fromImmunology to the solution of clinicalproblems.
• Textbook reading => Help learn thedetails and build up comprehensiveknowledge of immunology
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Dr. Mohamed Farouk Elshal
Evaluation
For the Immunology Section:
• Examination => 70 %
• Attendance & Class performance=> 30%
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Dr. Mohamed Farouk Elshal
What isImmunity?
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Dr. Mohamed Farouk Elshal
Immunity• Immunity
– The ability of the body to fight infection and/or foreign invaders byproducing antibodies or killing infected cells.
• Immune System– The system in the body responsible for maintaining homeostasis
by recognizing harmful from nonharmful organisms and producesan appropriate response.
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Dr. Mohamed Farouk Elshal
Foreign Invaders• Called Pathogens
– Viruses, bacteria or other living thingthat causes disease/immune response.
• Antigens– Toxins that pathogens produce that
cause harm to an organism.– A molecule which elicits a specific
immune response when introduced intoan animal.
More specifically, antigenic (immunogenic)substances are:
– Generally large molecules (>10,000daltons in molecular weight),
– Structurally complex (proteins areusually very antigenic),
– Accessible (the immune system must beable to contact the molecule), and
– Foreign (not recognizable as "self").
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Dr. Mohamed Farouk Elshal
Epitopes: Antigen Regions that Interact withAntibodies
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Dr. Mohamed Farouk Elshal
Components of Human Immune System
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Dr. Mohamed Farouk Elshal
Components of Human Immune System
CELLS OF THE IMMUNE RESPONSE
Cells:Blood - White Blood Cells in particular.
1. B-cells2. T-cells [Helper T-cells (TH), Suppressor T-cells
(TS), Cytotoxic T-cells (CTL) ]3. Accessory cells [Macrophages, Dendritic cells,
Polymorphonuclear cells (PMNs)]4. Killer cells [NK cells, K cells]5. Mast cells
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Dr. Mohamed Farouk Elshal
Components of Human Immune System
Lymphoid Tissues:• Thymus Gland – Produces T
Lymphocytes• Bone Marrow – Produces B
Lymphocytes• Lymph nodes• Spleen
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Dr. Mohamed Farouk Elshal
LYMPHOID TISSUES
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Dr. Mohamed Farouk Elshal
LYMPHOID TISSUES
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Dr. Mohamed Farouk Elshal
How does the body fightinfection/foreign invaders?
• Administration of antitoxin (passive)• Vaccination (active)
Artificially acquired
• Placental transfer of antibody(passive)
• Recovery from disease (active)
Specific (acquired) Naturallyacquired
• Intact skin• Mucous membranes• Phagocytic cells• Enzymes in secretions• Cytokines (Interferon)
Nonspecific (innate)
ExamplesTypes of Immunity
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Dr. Mohamed Farouk Elshal
How does the body fightinfection/foreign invaders?
The Body’s THREE lines of DefenseFirst Line of Defense – The Skin
• Provides Physical and Chemical barriers• Physical – hard to penetrate, made of indigestible keratin• Chemical – tears, sweat
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Dr. Mohamed Farouk Elshal
Second Line of Defense –Nonspecific Immune Response
These are defenses the body uses no matter what the invadermay be. These defenses include:– Phagocytosis – done by Macrophages– Natural Cell Killers– Inflammation - caused by release of Histamine from leukocytes– Fever – caused by histamines. The fever (high temp) kills invaders by
denaturing their proteins.
Macrophage: A phagocytic cell found in the liver, spleen, brain and lungs. Travels
to all areas of the body to find and eat pathogens.
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Dr. Mohamed Farouk Elshal
This is a specific response to a specificpathogen/antigen.
• The response involves the creation of Antibodies.
Third Line of Defense –Specific Immune Response
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Dr. Mohamed Farouk Elshal
Innate Immunity
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Dr. Mohamed Farouk Elshal
Innate immunity
Innate immunity is the older host defense system:- Existed in both Invertebrates & Vertebrates- Provides the initial defense against infections- Activates and shapes adaptive immune responses
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Dr. Mohamed Farouk Elshal
Inflammation
=>A hallmark of innate immunity=>Local accumulation of immune cells & molecules
against microbes=>Function to eliminate infections but often cause
tissue damage & disease
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Dr. Mohamed Farouk Elshal
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Dr. Mohamed Farouk Elshal
Epithelial barriers prevent theentry of microbes
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Dr. Mohamed Farouk Elshal
Movements of phagocytic cells
• Ameboid movement.Phagocytic cellsmigrate in and out ofblood vessels andthroughout thetissues.
• The process ofcellular emigrationfrom capillaries iscalled diapedesis.
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Dr. Mohamed Farouk Elshal
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Dr. Mohamed Farouk Elshal
Phagocytosis during innate immunity
Stages in phagocytosisA. Phagocyte detects chemicals released by a foreign
intruder (e.g. bacteria)
B. Phagocyte moves up the concentration gradienttowards the intruder
C.The phagocyte adheres to the foreign cell and engulfs itin a vacuole by an infolding of the cell membrane.
D.Lysosomes (organelles which are rich in digestiveenzymes & found in the phagocytes cytoplasm) fusewith the vacuole & release their contents into it leadingto killing the bacterium by the enzymes, and thebreakdown products are absorbed by the phagocyte.
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Dr. Mohamed Farouk Elshal
Phagocytosis during innate immunity
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Dr. Mohamed Farouk Elshal
Phagocytosis during innate immunity
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Dr. Mohamed Farouk Elshal
Adaptive Immunity
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Dr. Mohamed Farouk Elshal
Adaptive Immunity
Immunity that an organism develops duringlifetime.– Not genetically determined.– May be acquired naturally or artificially.
• Development of immunity to measles inresponse to infection or vaccination.
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Dr. Mohamed Farouk Elshal
Naturally Acquired Immunity
I. Obtained in the course of daily life.A. Naturally Acquired Active Immunity:– Antigens or pathogens enter body naturally.– Body generates an immune response to
antigens.– Immunity may be lifelong (chickenpox or
mumps) or temporary (influenza or intestinalinfections).
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Dr. Mohamed Farouk Elshal
Naturally Acquired Immunity (Continued)
I. Obtained in the course of daily life.B. Naturally Acquired Passive Immunity:– Antibodies pass from mother to fetus via
placenta or breast feeding (colostrum).– No immune response to antigens.– Immunity is usually short-lived (weeks to
months).– Protection until child’s immune system
develops.
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Dr. Mohamed Farouk Elshal
Artificially Acquired Immunity
II. Obtained by receiving a vaccine or immuneserum.1. Active Immunity:– Antigens are introduced in vaccines
(immunization).– Body generates an immune response to antigens.– Immunity can be lifelong (oral polio vaccine) or
temporary (tetanus toxoid).
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Dr. Mohamed Farouk Elshal
Vaccination (also called Immunization)
• The scientific view of immunity => EdwardJenner (1796)
• Observation => Milkmaids generally get Nosmallpox
• Hypothesis => Pus from vaccinia (cowpox)• => Protect milkmaids from smallpox• Test => Inoculate materials from cowpox pus• => Protect a young boy from smallpox• (Protective immunity)
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Dr. Mohamed Farouk Elshal
Edward Jenner
Eradication of smallpox
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Dr. Mohamed Farouk Elshal
Vaccines for common infectious diseases
Still no effective vaccines for many infectious microbes,ex. HCV, HIV, …..etc
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Dr. Mohamed Farouk Elshal
Artificially Acquired Immunity (Continued)
II. Obtained by receiving a vaccine or immuneserum.2. Passive Immunity:– Preformed antibodies (antiserum) are introduced
into body by injection.• Snake antivenom injection from horses or rabbits.
– Immunity is short lived (half life three weeks).– Host immune system does not respond to
antigens.
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Dr. Mohamed Farouk Elshal
– Serum: Fluid that remains after blood has clotted and cellshave been removed.
– Antiserum: Serum containing antibodies to a specificantigen(s). Obtained from injecting an animal (horse, rabbit,goat) with antigen (snake venom, botulism or diphtheriatoxin).
– Serology: The study of reactions between antibodies andantigens.
– Gamma Globulins: Fraction of serum that contains most ofthe antibodies.
– Serum Sickness: Disease caused by multiple injections ofantiserum. Immune response to foreign proteins. Maycause fever, kidney problems, and joint pain. Rare today.
Artificially Acquired Immunity (Continued)
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Dr. Mohamed Farouk Elshal
Active vs. Passive immunityActive immunity => A host response to a microbe (Ag)
=> specific and long-term immune defense (memory)Passive immunity => Adoptive transfer of Ab or lymphocytes
specific for a microbe (or Ag)=> specific, instant but transient immune defense
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Dr. Mohamed Farouk Elshal
Interaction between innate and& adaptive immunity
1. Innate immunity=> Ag presentation
(by infected cells)
2. Adaptive immunity=> Ag recognition
(by T & B lymphocytes)
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Dr. Mohamed Farouk Elshal
Innate vs Adaptive immunity
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Dr. Mohamed Farouk Elshal
Epitopes: Antigen Regions that Interact withAntibodies
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Dr. Mohamed Farouk Elshal
Innate vs Adaptive immunity
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Dr. Mohamed Farouk Elshal
Features of Adaptive immunity
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Dr. Mohamed Farouk Elshal
Types of adaptiveimmunity
1. Humoral immunity=> Molecules in body fluid,
ex. Antibody (Ab)=> Key player => B cells=> Target extracellular
microbes & toxins
2. Cell-mediated immunity=> Key player => T cells =>
regulate other immunecells
=> Target intracellularmicrobes, ex. viruses,bacteria
For innate immunity, it also includes Humoral & Cellularcomponents for immune defense
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Dr. Mohamed Farouk Elshal
Cellular Immunity .vs. AntibodyImmunity
• Carried out by T-Cells• Infected cells are killed by
Cytotoxic T –Cells.
• Carried out by B-cells• Antibodies are
produced anddumped into bloodstream.
• Antibodies bind toantigens anddeactivate them.
Cellular Immunity Antibody or Humoral Immunity
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Dr. Mohamed Farouk Elshal
Humoral Immunity
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Dr. Mohamed Farouk Elshal
Adaptive Humoral (Antibody-Mediated) Immunity
I. Humoral (Antibody-Mediated) Immunity– Involves production of antibodies against foreign antigens.
– Antibodies are produced by a subset of lymphocytes called Bcells.
– B cells that are stimulated will actively secrete antibodies andare called plasma cells.
– Antibodies are found in extracellular fluids (blood plasma, lymph,mucus, etc.) and the surface of B cells.
– Defense against bacteria, bacterial toxins, and viruses thatcirculate freely in body fluids, before they enter cells.
– Also cause certain reactions against transplanted tissue.
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Dr. Mohamed Farouk Elshal
How Do B Cells Produce Antibodies?
B cells develop from stem cells in the bonemarrow of adults (liver of fetuses).– After maturation B cells migrate to lymphoid organs
(lymph node or spleen).– Clonal Selection: When a B cell encounters an
antigen it recognizes, it is stimulated and divides intomany clones called plasma cells, which activelysecrete antibodies.
– Each B cell produces antibodies that will recognizeonly one antigenic determinant.
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Dr. Mohamed Farouk Elshal
Clonal Selection ofB Cells is Caused
by AntigenicStimulation
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Dr. Mohamed Farouk Elshal
Clonal Selection– Clonal Selection: B cells (and T cells) that
encounter stimulating antigen will proliferateinto a large group of cells.
– Why don’t we produce antibodies againstour own antigens? We have developedtolerance to them.
– Clonal Deletion: B and T cells that reactagainst self antigens appear to be destroyedduring fetal development. Process is poorlyunderstood.
Humoral Immunity (Continued)
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Dr. Mohamed Farouk Elshal
Apoptosis– Programmed cell death (“Falling away”).– Human body makes 100 million lymphocytes every
day. If an equivalent number doesn’t die, willdevelop leukemia.
– B cells that do not encounter stimulating antigenwill self-destruct and send signals to phagocytes todispose of their remains.
– Many virus infected cells will undergo apoptosis, tohelp prevent spread of the infection.
Humoral Immunity (Continued)
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Most are proteins or large polysaccharides from a foreignorganism.– Microbes: Capsules, cell walls, toxins, viral capsids,
flagella, etc.– Nonmicrobes: Pollen, egg white , red blood cell surface
molecules, serum proteins, and surface molecules fromtransplanted tissue.
Lipids and nucleic acids are only antigenic when combinedwith proteins or polysaccharides.Molecular weight of 10,000 or higher.– Hapten: Small foreign molecule that is not antigenic. Must be
coupled to a carrier molecule to be antigenic. Once antibodiesare formed they will recognize hapten.
Antigens
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Epitope:Small part of an antigen that interacts with anantibody.Any given antigen may have several epitopes.Each epitope is recognized by a differentantibody.
Antigens
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Epitopes: Antigen Regions that Interactwith Antibodies
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Antibodies• Y-shaped protein
molecule.• Made up of variable and
constant regions.• Made up of Heavy and
Light chains.• Produced by B-
Lymphocytes• Function: Recognize
antigens, bind to anddeactivate them.– Note: Variable region
recognizes the anitgens.
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One virus or microbe may have several antigenicdeterminant sites, to which different antibodies maybind.Each antibody has at least two identical sites that bindantigen: Antigen binding sites.Valence of an antibody: Number of antigen bindingsites. Most are bivalent.Affinity: A measure of binding strength.Belong to a group of serum proteins calledimmunoglobulins (Igs).There are five classes of antibodies: IgD, IgM, IgG, IgA,and IgE
Antibodies
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Dr. Mohamed Farouk Elshal
IgM – pentamer released by plasma cells during theprimary immune response
IgA – dimer that helps prevent attachment ofpathogens to epithelial cell surfaces
IgG – monomer that is the most abundant anddiverse antibody in primary and secondaryresponse; crosses the placenta and conferspassive immunity
IgE – monomer that binds to mast cells andbasophils, causing histamine release whenactivated
IgD – monomer attached to the surface of B cells,important in B cell activation
Classes of Antibodies
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• Antibodies themselves do not destroy antigen;they inactivate and tag it for destruction
• All antibodies form an antigen-antibody(immune) complex
• Defensive mechanisms used by antibodiesare:
1. neutralization,2. agglutination,3. precipitation, and4. complement fixation
Antibody mechanisms of action
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1. Agglutination: Antibodiescause antigens (microbes) toclump together.• Enhances phagocytosis• Reduces number of infectious
units to be dealt with• IgM (decavalent) is more
effective than IgG (bivalent).• Hemagglutination:
Agglutination of red blood cells.Used to determine ABO bloodtypes and to detect influenzaand measles viruses.
Consequences of Antigen-Antibody Binding
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Dr. Mohamed Farouk Elshal
2. Opsonization: Antigen(microbe) is coveredwith antibodies thatenhances its ingestionand lysis by phagocyticcells.
3. Neutralization: IgGinactivates viruses bybinding to their surfaceand neutralize toxins byblocking their activesites.
Consequences of Antigen-Antibody Binding
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Dr. Mohamed Farouk Elshal
4. Antibody-dependentcell-mediatedcytotoxicity (ADCC):– Used to destroy large
organisms (e.g.: worms).– Target organism is coated
with antibodies andbombarded withchemicals fromnonspecific immune cells.
Humoral Immunity (Continued)
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5. ComplementActivation: Both IgGand IgM trigger thecomplement systemwhich results in cell lysisand inflammation.
Humoral Immunity (Continued)
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Humoral Immunity (Continued)
6. Disruption of cell bycomplement/reactiveprotein attractsphagocytic and otherdefensive immunesystem cells
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• Antibody Titer: The amount of antibody inthe serum.
• Pattern of Antibody Levels During InfectionPrimary Response:
– After initial exposure to antigen, no antibodiesare found in serum for several days.
– A gradual increase in titer, first of IgM and thenof IgG is observed.
– Most B cells become plasma cells, but some Bcells become long living memory cells.
– Gradual decline of antibodies follows.
Immunological Memory
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Secondary Response:– Subsequent exposure to the same antigen
displays a faster and more intense antibodyresponse.
– Increased antibody response is due to theexistence of memory cells, which rapidlyproduce plasma cells upon antigenstimulation.
Immunological Memory (Continued)
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Antibody Response After Exposure to Antigen
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Cellular Immunity
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Specific Immune ResponseII. Cell Mediated Immunity
– Involves specialized set of lymphocytes calledT cells that recognize foreign antigens on thesurface of cells, organisms, or tissues:• Helper T cells• Cytotoxic T cells
– T cells regulate proliferation and activity ofother cells of the immune system: B cells,macrophages, neutrophils, etc.
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• T cells recognize and respond only toprocessed fragments of antigen displayedon the surface of body cells (exogenousantigens)
• T cells are also recognize and targetintracellular antigens like:– Cells infected with viruses, bacteria, or
intracellular parasites– Abnormal or cancerous cells– Cells of infused or transplanted foreign tissue
Importance of Cellular Response
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Cell Mediated Immunity
• Requires constant presence of antigen to remain effective.
• Unlike humoral immunity, cell mediated immunity is nottransferred to the fetus.
• Cytokines: Chemical messengers of immune cells.– Over 100 have been identified.
– Stimulate and/or regulate immune responses.• Interleukins: Communication between WBCs.
• Interferons: Protect against viral infections.
• Chemokines: Attract WBCs to infected areas.
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• Immunocompetent T cells are activatedwhen the V regions of their surfacereceptors bind to a recognized antigen
• T cells must simultaneously recognize:– Nonself (the antigen)– Self (a MHC protein of a body cell)
Antigen Recognition and MHCRestriction
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• The Major Histocompatibility Complex (MHC) isa set of molecules displayed on cell surfacesthat are responsible for lymphocyte recognitionand "antigen presentation".
• The MHC molecules control the immuneresponse through recognition of "self" and "non-self" and, consequently, serve as targets intransplantation rejection.
MAJOR HISTOCOMPATIBILITYCOMPLEX
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• The Class I and Class II MHC moleculesbelong to a group of molecules known asthe Immunoglobulin Supergene Family,which includes immunoglobulins
• Both types of MHC proteins are importantto T cell activation
MAJOR HISTOCOMPATIBILITYCOMPLEX
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• Class I MHC proteins– Always recognized by CD8 cytotoxic T cells
(CTL)– Display peptides from endogenous antigens
• Endogenous antigens are:– Degraded by proteases and enter the
endoplasmic reticulum– Loaded onto class I MHC molecules– Displayed on the cell surface in association
with a class I MHC molecule
Class I MHC Proteins
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• Class II MHC proteins are found only onmature B cells, some T cells, and antigen-presenting cells
• Loaded Class II MHC molecules thenmigrate to the cell membrane and displayantigenic peptide for recognition by CD4 Thelper cells (Th-cells).
Class II MHC Proteins
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MHC Proteins and antigen recognition
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T Cells Only Recognize Antigen Associated withMHC Molecules on Cell Surfaces
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Cell Mediated Immunity
• Immune responsive cells can be dividedinto five groups based on the presence ofspecific surface components and functioninto:
1. lymphocytes (B-cells, and T-cells).2. Accessory cells (Macrophages and other antigen-
presenting cells),3. Killer cells (NK and K cells), and4. Mast cells.
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B-lymphocytesSurface components• Surface immunoglobulin (Ag recognition)• Immunoglobulin Fc receptor• Class II Major Histocompatability Complex
(MHC) molecule (Ag presentation)Function• Direct antigen recognition• Differentiation into antibody-producing plasma
cells• Antigen presentation within Class II MHC
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T-lymphocytes
Surface components• CD3 moleculeFunction• T-cell receptor (TCR, Ag recognition)• Involved in both humoral and cell-
mediated responses
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– T cells are key cellular component of immunity.– T cells have an antigen receptor that recognizes
and reacts to a specific antigen (T cell receptor).– T cell receptor only recognize antigens combined
with major histocompatability (MHC) proteins onthe surface of cells.
• MHC Class I: Found on all cells.• MHC Class II: Found on phagocytes.
– Clonal selection increases number of T cells.
T-lymphocytes
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Major Types of T CellsHelper T-cells (TH)
Surface components• CD4 moleculeFunction• Recognizes antigen presented within
Class II MHC• Promotes differentiation of B-cells and
cytotoxic T-cells• Activates macrophages• Stimulate B cells to produce antibodies.
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Central Role of Helper T Cells
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Suppressor T-cells (TS)
Surface components• CD8 moleculeFunction• Downregulates the activities of other cells
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Cytotoxic T-cells (CTL)
Surface components• CD8 moleculeFunction• Recognizes antigen presented within Class I
MHC• Release protein called perforin which forms a
pore in target cell, causing lysis of infected cells.• Undergo apoptosis when stimulating antigen is
gone.
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Cytotoxic T Cells Lyse Infected Cells
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Types of T cells (Continued)
• Delayed Hypersensitivity T (TD) Cells:Mostly T helper and a few cytotoxic T cellsthat are involved in some allergic reactions(poison ivy) and rejection of transplantedtissue.
• T Suppressor (Ts) Cells: May shut downimmune response.
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Nonspecific Cellular Components
Natural Killer (NK) Cells:– Lymphocytes that destroy virus infected and tumor
cells.– Not specific. Don’t require antigen stimulation.– Not phagocytic, but must contact cell in order to lyse
it.• Surface components
– Variable• Function
– Direct cell killing– Kills variety of target cells (e.g. tumor cells, virus-
infected cells, transplanted cells)
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Nonspecific Cellular Components
Polymorphonuclear cells (PMNs)• Surface components
– Immunoglobulin Fc receptor– Complement component C3b receptor
• Function– Bind Fc portion of immunoglobulin (enhances
phagocytosis)– Bind complement component C3b (enhances
phagocytosis)
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Dr. Mohamed Farouk Elshal
Nonspecific Cellular Components
Macrophages• Surface components
– Variable– Immunoglobulin Fc receptor– Complement component C3b receptor– Class II MHC molecule
• Function– Bind Fc portion of immunoglobulin (enhances phagocytosis)– Bind complement component C3b (enhances phagocytosis)– Antigen presentation within Class II MHC– Secrete IL-1 (macrokine) promoting T-cell differentiation and
proliferation– Can be "activated" by T-cell lymphokines
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Nonspecific Cellular Components
Dendritic cells• Surface components
– Class II MHC molecule• Function
– Antigen presentation within Class II MHC
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Nonspecific Cellular Components
Mast cells• Surface components
– High affinity IgE Fc receptors• Function
– Bind IgE and initiate allergic responses byrelease of histamine
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1. Antibody ProductionT-Dependent Antigens:
– Antibody production requires assistance from T helper cells.
– A macrophage cells ingest antigen and presents it to TH cell.
– TH cell stimulates B cells specific for antigen to become plasma cells.
– Antigens are mainly proteins on viruses, bacteria, foreign red blood cells,and hapten-carrier molecules.
T-Independent Antigens:– Antibody production does not require assistance from T cells.
– Antigens are mainly polysaccharides or lipopolysaccharides with repeatingsubunits (bacterial capsules).
– Weaker immune response than for T-dependent antigens.
Relationship Between Cell-Mediatedand Humoral Immunity
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Humoral Response to T DependentAntigens
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The Pathway of Specific ImmuneResponse
Pathogens
Pathogens eaten by Macrophage
Displays portion of Pathogenon surface
Helper-T cell recognizesPathogen
Step 1
Step 2
Step 3
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Activates B- CellActivates Cytotoxic
T- Cell
Memory B-CellMemory T-Cell
Kills Infected CellsAntibodies
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Immune Response Explained1. Antigen infects cells.2. Macrophage ingests antigen and displays portion on its surface.3. Helper T- Cell recognizes antigen on the surface of the
macrophage and becomes active.4. Active Helper T-Cell activates Cytotoxic T-Cells and B-Cells.5. Cytotoxic T-Cells divide into Active Cytotoxic T-cells and Memory
T – Cells.6. Active Cytotoxic T-Cells kill infected cells.7. At the same time, B-Cells divide into Plasma Cells and Memory
B- Cells.8. Plasma cells produce antibodies that deactivate pathogen.9. Memory T and Memory B cells remain in the body to speed up the
response if the same antigen reappears.10. Supressor T-Cells stop the immune response when all antigens
have been destroyed.
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Dr. Mohamed Farouk Elshal
Immune Response Summary
Antigen
Macrophage
Helper T - Cell
Active Cytotoxic T-Cell Active B - Cell
Kills Infected Cells Memory T- Cell Plasma Cell Memory B-Cell
Antibodies
Deactivates Antigens
Displays copy of antigenon surface of cell
Cellular Immunity Antibody Immunity
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Dr. Mohamed Farouk Elshal
Overview of the Immune Response
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Dr. Mohamed Farouk Elshal
Primary .vs. Secondary ImmuneResponse
• Primary Immune Response– This is a response to an invader the First time the
invader infects the body.• No measurable immune response for first few days.• Next 10 – 15 days antibody production grows steadily
• Secondary Immune Response– A more rapid response to an invader the 2nd time it
invades the body.• Antibody production increases dramatically and in a much
shorter time period..
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Dr. Mohamed Farouk Elshal
Primary .vs. Secondary ImmuneResponse
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Dr. Mohamed Farouk Elshal
SUMMARY
1. Protective immunity against microbes is mediated by theearly response of innate immunity and the later response ofadaptive immunity.
2. Innate immune responses are initiated by recognition ofcommon microbial structures by- Provide the first line of host defense- Activate and regulate the adaptive immunity
3. Adaptive immune responses are initiated by recognition offoreign antigens by specific lymphocytes.- Provide more potent, specific (Ag), & broad protection- Develop immune memory for next exposure- Feedback regulate innate immunity
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Dr. Mohamed Farouk Elshal
Failure of the immune system
Ineffective response-Immunodeficiency
Overactive response-Hypersensitivity
Auto-reactive response-Autoimmunity
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Dr. Mohamed Farouk Elshal
Autoimmune Disease
• Autoimmune diseases are diseases where the immunesystem begins to attack itself.– Ex:
• Rheumatoid Arthritis – crippling disease of thejoints.
• Lupus – disease of blood and organs.• Multiple Sclerosis – disease of nervous system
• Cause(s): unknown• Cures/Treatments: No known cures. Usually treated
with drugs.
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Dr. Mohamed Farouk Elshal
AllergiesAllergy
- An exaggerated response by the immune system to an allergen.
Allergen: a normally harmless substance that causes an allergicreaction.ex: dust, pollen, mould, food, insect stings
Types of Allergic reactionsThere are two types of allergic reactions.
a. Immediate – occurs within seconds and normally lasts for about30 mins.b. Delayed – takes longer to react and can last for a much longertime.
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Dr. Mohamed Farouk Elshal
What happens during an allergicreaction?
• During an allergic reaction antibodies cause histamines to bereleased from certain cells.
Histamines cause:a. Swelling of tissuesb. Release of fluids (runny noses and eyes)c. muscle spasms (some cases)
Anaphylaxis or anaphylactic shock:This is the sudden and severe allergic reaction to a substance thatcan cause death.
Treatments for Allergies1.Avoidance of material – especially food.2.Epinephrine – “epi – pen”3.Antihistamines -- benadryl