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Heinrich HomeyerSummer School 05 2Ionenstrahllabor Hahn-Meitner-Institut Berlin
Fast Light and Heavy Ions in Medicine, Materials Analysis and Materials Modifications
IntroductionISL Facility
AcceleratorsIons & Energies
Proton TherapyOcular MelanomaGeneral Remarks
Analytical ToolsERDAPIXE
Industrial ApplicationsIrradiation of PolymerFoilSingle Event Effects
Conclusions
Student Summer SchoolDubna
July 2005
H. HomeyerHahn-Meitner Institut Berlin
Heinrich HomeyerSummer School 05 3Ionenstrahllabor Hahn-Meitner-Institut Berlin
Introduction: Accelerator Tree
CommercialAccelerators
(Industrial Production, industrial research &
clinics
4 Synchrotrons4 HE Zyklotrons
300 Zyklotrons2000 v.d. Graaffs7000 Implanters
Medical Applications,Isotope PET
Mikro-Structures
Lithography
Nuclear Physics
IonImplantation
Semi-conductors
PIXE ERDA
StorageRings
RBS
AMS
Linacs
Medical Applications,
Radiation-Therapy
1995
1985
1975
1965
Electrostatic Accelerators
Cyclotrons
1930
Heinrich HomeyerSummer School 05 4Ionenstrahllabor Hahn-Meitner-Institut Berlin
Introduction: Features of “Fast Ions”
targetprojectile sample
sample
sampleprojectile
Fast ionsproduce radioisotopes
Radiotracers forMedical DiagnosticsRadiotherapyTribology
analysis of local structures in solids
are scattered bynuclei (Rutherford scattering)
Materials AnalysisThin LayersElasticRecoilDetectionAnalysis
RutherfordBackScattering
most likely byelectrons Thick Samples
ProtonInducedX-rayEmission
energy loss of fast ions due to electronic excitations!
Heinrich HomeyerSummer School 05 5Ionenstrahllabor Hahn-Meitner-Institut Berlin
Introduction: The Electronic Energy Loss
HC Ne
Ar
KrXe
Au
20 40 60 8010-1
100
101
102
LET
in S
i (M
eV/(m
g/cm
2 ))
Ener
gy/A
tom
ic M
ass
(MeV
/u)
Ion Atomic Number
RFQ-cyclotron combination
0.5
100.0
CB
Large variation of the electronic energy loss with particles` nuclear charge and energy !
Heinrich HomeyerSummer School 05 6Ionenstrahllabor Hahn-Meitner-Institut Berlin
Introduction: Properties of Energetic Heavy Ions
high electronic excitation10-17 - 10-13 s, 20 eV/atom
heating and particle emission 10-13 - 10-11 s
frozen-in atomic rearrangements> 103 s, 10 nm Ø
Energy deposition- large- fast- local
Straight-linedPath
Large penetration depth 104
105
103
102
101
1
visiblelight
electrons
heavyions
x-rays
Aspect Ratio ion track
µm - mm
~10 nm
Heinrich HomeyerSummer School 05 7Ionenstrahllabor Hahn-Meitner-Institut Berlin
ISL Facility: Overview
Eye-Tumour-Therapy
ERDA
PIXEFoil IrradiationRFQ
Magnetic SpectrometerRecoil Implantation
Dual-Beam Line BIBER
200 kV Platformwith ECR-ion Source
5.5 Mv van de Graaff
High Dose IrradiationX-ray DiffractometerElectron SpectrometerLaser
RBSβ-NMR
Dedicated Facility for Fast Ions in Medicine, Materials Analysis & Modifications
Heinrich HomeyerSummer School 05 8Ionenstrahllabor Hahn-Meitner-Institut Berlin
ISL: Separated Sector Cyclotron
Sectors 4Dees 2Bending Limit k=135Frequency 10-20 MHzHarmonics 2-8Inner Radius 40 cmExtraction Radius 172 cmMax. Average Field 1.2 Tesla
Heinrich HomeyerSummer School 05 9Ionenstrahllabor Hahn-Meitner-Institut Berlin
ISL: Radio-Frequency-Quadrupole Injector
Specifications
Injector for Heavy Ions• Mass to charge ratio 5 to 8• Number of structures 2• Structure length 1.4 m• Operating frequency 85 - 120 MHz• Maximum electrode voltage 50 kV
Two Structures• Structure 1
Beam aperture diameter 4 mmEnergy gain factor 6
Structure 2 • Energy gain factor
• Transport mode 0• Acceleration mode 2
Output energy• RFQ alone (keV/A) 90 to 360• Cyclotron (MeV/A) 1.5 to 6
electrical fields betweenthe RFQ electrodes
Heinrich HomeyerSummer School 05 10Ionenstrahllabor Hahn-Meitner-Institut Berlin
ISL: Van de Graaff Injector 5.5 MV
Special Feature: Light Ion Injector– Terminal
• 5 GHz ECR-Ion Source• Fast High Voltage Regulation System• Buncher
– Beam• Low Energy Spread• Very Stable
Particles have to pass a stripper(gas or foil) before injection
0 100 200 300 4000,0
0,2
0,4
0,6
0,8
1,0
Bea
m In
tens
ity (µ
A)
Time (s)
Stability of the analysed beam
Heinrich HomeyerSummer School 05 11Ionenstrahllabor Hahn-Meitner-Institut Berlin
Introduction: The Electronic Energy Loss
HC Ne
Ar
KrXe
Au
20 40 60 8010-1
100
101
102
LET
in S
i (M
eV/(m
g/cm
2 ))
Ener
gy/A
tom
ic M
ass
(MeV
/u)
Ion Atomic Number
RFQ-cyclotron combination
0.5
100.0
CB
Large variation of the electronic energy loss with particles` nuclear charge and energy !
Heinrich HomeyerSummer School 05 12Ionenstrahllabor Hahn-Meitner-Institut Berlin
ISL Facility: Overview
Masses: 1 ... 200Energies: 1.5-6 MeV/amu (RFQ-Injector)
30 MeV/amu (light Ions)70 MeV Protons
LET: 0,5 ... 80 keV/nmDose Rate: 1 ... 1011 part/secTotal Dose: 1014/cm2
Area: 10-4 ... 102 cm2
Heinrich HomeyerSummer School 05 13Ionenstrahllabor Hahn-Meitner-Institut Berlin
ISL Facility: Location
Heinrich HomeyerSummer School 05 14Ionenstrahllabor Hahn-Meitner-Institut Berlin
Radiation Therapy: Basics
0,00
50,00
100,00
0 5 10 15 20 25Dose [arbitrary units]
Effe
ct [%
] Normal tissueTumorEfficiancy
Reduction of Side Effects : Concentration of the dose on tumor tissue
Heinrich HomeyerSummer School 05 15Ionenstrahllabor Hahn-Meitner-Institut Berlin
Radiation Therapy: Advantage of Protons
electrons γ-rays proton beam
rela
tive
dose
depthConcentration of dose with“conventional” radiationbest solution: IMRTComparison of different depth
dose distributions: Protons have an inverse depth dose profile!
Heinrich HomeyerSummer School 05 16Ionenstrahllabor Hahn-Meitner-Institut Berlin
Proton Therapy: Advantage of Protons
0 10 20 300
20
40
60
80
100
Tiefe in Wasser [mm]
rela
tive
Dos
is [%
] SOBP Production of a homogeneous depthdose profile:Weighted adding of different energies
Simplest solution:Modulator wheel
Heinrich HomeyerSummer School 05 17Ionenstrahllabor Hahn-Meitner-Institut Berlin
Proton Therapy: General Layout
Passive Formation of the Radiation Field:ScatteringApertures, Range Shifter & Modulator
Heinrich HomeyerSummer School 05 18Ionenstrahllabor Hahn-Meitner-Institut Berlin
Proton Therapy of Ocular Melanomas
X-RayTube
PatientCollimatorr
Ta - Markerss
ProtonBeam
DoseRateMonitorr
FixationLightt
TumorRangeModulator
Monitor
X-RayScreen
RangeShifter
Heinrich HomeyerSummer School 05 19Ionenstrahllabor Hahn-Meitner-Institut Berlin
Tumor Therapy: Set-up
Range Shifter
Range Modulator
Patient Mask
Patient Aperture
Fixation Light
Heinrich HomeyerSummer School 05 20Ionenstrahllabor Hahn-Meitner-Institut Berlin
Therapy: Preparation
Clinic:Diagnostics, Indication
Preparations Clip-Surgery, Image (CT, MRI, Ultrasound)
Localization:Mask Production, Clip Verification
Treatment Planning:Treatment Plan, Simulation
Heinrich HomeyerSummer School 05 21Ionenstrahllabor Hahn-Meitner-Institut Berlin
Therapy Preparation: Tumor Identification
Fundus-ViewForm of TumourTumor SiteTumor-Macula-DistanceTumor-Optical Nerve-Distance
Eye-CT / MRTTumor SiteEye Geometry
Heinrich HomeyerSummer School 05 22Ionenstrahllabor Hahn-Meitner-Institut Berlin
Therapy: Clip Clip SurgerySurgery
Heinrich HomeyerSummer School 05 23Ionenstrahllabor Hahn-Meitner-Institut Berlin
Therapy: Fixing The Patient
BiteBite blockblock
MaskMask
Patient Patient chairchair
Heinrich HomeyerSummer School 05 24Ionenstrahllabor Hahn-Meitner-Institut Berlin
Therapy: Localisation (Clip Verification)
XX--rayray
axial axial picturepicture
lateral lateral picturepicture
Heinrich HomeyerSummer School 05 25Ionenstrahllabor Hahn-Meitner-Institut Berlin
Therapy: Treatment Planning
EYEPLAN:EYEPLAN:M. M. GoiteinGoitein, T. Miller, 1983, T. Miller, 1983
ClipsClips
Heinrich HomeyerSummer School 05 26Ionenstrahllabor Hahn-Meitner-Institut Berlin
Therapy: Treatment Plan
Proton Beam
Direction to theFixing Light Iso-dose Oktopus
Iso-dose Lines Eyeplan
Heinrich HomeyerSummer School 05 27Ionenstrahllabor Hahn-Meitner-Institut Berlin
Therapy: Patient Positioning
Transfer of ParametersTransfer of ParametersChair position Chair position
Fixing light positionFixing light position
Clip projectionClip projection
ApertureAperture
TREAT:TREAT:M. Fromme (HMI), 1998M. Fromme (HMI), 1998
Heinrich HomeyerSummer School 05 28Ionenstrahllabor Hahn-Meitner-Institut Berlin
Therapy: Simulation
Direction to Direction to Fixation LightFixation Light
RangeRange
Modulation DepthModulation Depth
Heinrich HomeyerSummer School 05 29Ionenstrahllabor Hahn-Meitner-Institut Berlin
Therapy: Treatment Fixation LightFixation Light
Beam Beam LineLine
ApertureAperture withwith WedgeWedge FilterFilterEye Lid Eye Lid
RetractorRetractor
Heinrich HomeyerSummer School 05 30Ionenstrahllabor Hahn-Meitner-Institut Berlin
Therapy: Patient Positioning
Treatment PlanTreatment Plan
Transfer of ParametersTransfer of Parameters
XX--Ray Ray -- ControlControl
Heinrich HomeyerSummer School 05 31Ionenstrahllabor Hahn-Meitner-Institut Berlin
Therapy: Positioning
Heinrich HomeyerSummer School 05 32Ionenstrahllabor Hahn-Meitner-Institut Berlin
MisalignmentMisalignment
Position-Corrections
Angle-Correction
Simulation –1. Fraction
0,5 - 1 mm(up to 3 mm)
5°(up to 20°)
3. Fraction –4. Fraction 0 - 0,5 mm 0° - 2°
ReasonsReasons::
dayday--to day to day variationvariation of of sittingsitting
Eye Eye lidlid retractorretractor in in contactcontact withwith thethe eyeeye
PostPost--surgery swellingsurgery swelling of of the eyethe eye lidlid
Therapy: Positioning
Heinrich HomeyerSummer School 05 33Ionenstrahllabor Hahn-Meitner-Institut Berlin
Radiotherapy with protons
Start 19982004 first follow-up publication of 250 patients95% local tumor controlJun. 2005 total number of patients > 700
Several projectsFor a dedicated 250 MeVproton cyclotron
Kluge, Heufelder, Cordini, Semiantonakis, Stark, Weber
Heinrich HomeyerSummer School 05 34Ionenstrahllabor Hahn-Meitner-Institut Berlin
Superconducting Cyklotron
ACCEL-Design
Advantage• Large pole gap• Low energy
consumption
• First patients are plannedby the end 2005
Heinrich HomeyerSummer School 05 35Ionenstrahllabor Hahn-Meitner-Institut Berlin
Materials Analysis with Ion BeamsScattering of ions from electrons or nuclei inside the
sample
Single event Analysis
ElectronsPIXE
Projectile E0
E1
Nucleus of anatom in thesample
E2
θ
φ
Mp
Mr
Mp
NucleiERDA
Heinrich HomeyerSummer School 05 36Ionenstrahllabor Hahn-Meitner-Institut Berlin
High-Energy-Elastic-Recoil-Detection-AnalysisProjektil E0
E1
Targetatom
E2
θ
φ
Mp
Mr
Mp
φ3
22
0
2
cos1
2dd
⎟⎟⎠
⎞⎜⎜⎝
⎛ +⎟⎟
⎠
⎞
⎜⎜
⎝
⎛=
r
rprprMMM
EeZZ
Ωσ
φ32
22
0
2
cos1
2dd
prrpr Z
MZ
EMe
Ωσ
⎟⎟⎠
⎞⎜⎜⎝
⎛⎟⎟
⎠
⎞
⎜⎜
⎝
⎛=⇒>> rp MM
2
2
)(
)(cos4
rp
rpr
MM
MMk
+=
φ02 EkE r=
Depth resolution: some nmTotal depth: some µm•Heavy Masses
•Sharp Bombarding Energy•Low Beam Emittance
Heinrich HomeyerSummer School 05 37Ionenstrahllabor Hahn-Meitner-Institut Berlin
High-Energy-Elastic-Recoil-Detection-Analysis
10 cm
17 cm 120 cm
Ion beam
channelplatestop detector
mirror channel platestart detector
SBenergy detector
Method of particle identification: time-of-flight (velocity) & energy
Advantages Isotopic resolutionLow energy threshold– Larger depth area
Exact energy calibration via time-of-flight– Better depth resolution
Heinrich HomeyerSummer School 05 38Ionenstrahllabor Hahn-Meitner-Institut Berlin
High-Energy-Elastic-Recoil-Detection-Analysis
Examples
350 MeV Au26+ aufZnSe/Cu(Ga,In)(S,Se)2/Mo/GlasSolar cell material:
Diffusion of In from the absorberinto the buffer layer
Heinrich HomeyerSummer School 05 39Ionenstrahllabor Hahn-Meitner-Institut Berlin
Materials Analysis: ERDA - Features
only absolute, standard free method for the concentration of all elements in thin layerslarge dynamic range in energy (depth) due to TOF methoddepth profiles for all elements in layers up to 3 µmalmost the same high sensitivity for all elements (0.001 at%)hydrogen sensitivity is enhanced by a factor of 4using heavy projectiles, no restrictions on the detectable mass rangedepth resolution up to 10 nm near the surface
Heinrich HomeyerSummer School 05 40Ionenstrahllabor Hahn-Meitner-Institut Berlin
Materials Analysis: PIXE - Principle
Proton Induced X-ray Emission
multi elemental analysis – in vacuum from Na, in air from K, no organic materials
– determination of the elements, not chemical bond
Coelin blue (CoO·nSnO2 - Azurite (blue) (2CuCO3·Cu(OH)2)Malachite (green) (CuCO3·Cu(OH)2
non-destructive: in air and at small beam intensities
standard technique: proton energies up to 4 MeVanalytical depth at these energies: max. 100 µm
Heinrich HomeyerSummer School 05 41Ionenstrahllabor Hahn-Meitner-Institut Berlin
Analysis: High-Energy PIXE
1 10 100 10000
5
10
15
20
25
0.00
0.05
0.10
0.15
0.20
0.25Protonen in Kupfer
Se, 70 MeV
Se, 3 MeV
σ KX 70 MeV
σ LX /103 MeV
Pb Lα1
E=10.5keVd(10%)
Pb Kα1 E=74.957keV
d(10%)
Stop
ping
Pow
er (M
eV/(m
g cm
2 ))
Wirk
ungs
quer
schn
itt (b
arn)
Tiefe (µm)
Comparison with low energy PIXE
Test of the method: Thin Au foil insidea 3mm thick lead glass
Heinrich HomeyerSummer School 05 42Ionenstrahllabor Hahn-Meitner-Institut Berlin
K Lines
Z> 50
large
range
L/Kratio
Analysis: Highenergy - PIXE
low risk for fragile or delicate Objects
at strongabsorption
thick layers
Information oninner structure
Volume-analysis
Small dE/dx
γLinie
(PIGE)
why70 MeV?
Heinrich HomeyerSummer School 05 43Ionenstrahllabor Hahn-Meitner-Institut Berlin
Provenienc
e
datin
gProduction process
Information from Element Identification
Ming orfake?(composition of colours)
Loss of copper in Silver coins
Indirect dating(pigments used)
Determination-of manufacture site(metals used)
compositionmassive? gilded?
Authenticity
Conservation/Restoration
Archeology/History of Art
Heinrich HomeyerSummer School 05 44Ionenstrahllabor Hahn-Meitner-Institut Berlin
PIXE: experimental set-up
beam exit: thin Kaptonfoilmoveable mirror inflects laser on beam axistwo detectors at 135°shielding against radiation from exit foilxy tablecamcorder surveys and documents beam spot
protons from accelerator
HPGeSi(Li)
moveablemirror
shielding
object
laser beam
foil
xy table
Heinrich HomeyerSummer School 05 45Ionenstrahllabor Hahn-Meitner-Institut Berlin
Materials Analysis: PIXE - Setup
object(3600 years old Egyptian coffin)
HPGe180eV
Si(Li)155eV
xy-table
camera(documentation)
shielding
beam exit:80 µm Kapton, 10 cm air∆E ~ 200 keV, 1mm Ø
moveable mirror:inflected laser beam
Heinrich HomeyerSummer School 05 46Ionenstrahllabor Hahn-Meitner-Institut Berlin
Materials Analysis: PIXE - Example
~ 6cm
630 - 660: disc brooches were used by noble ladies, iron objects with gold-or silver coloured decoration1940 - 1973: excavation of the grave field in Eltville, 646 graves, one of the largest in Germany1955 - 1975: restoration of objects state of the art technique at that time: stabilisation and corrosion prevention by plastic coveranalytical task: non-destructive identification of metals used for manufacture
rivet head
needle
iron inlay
ornamentsrivet cap
rivet
plastic cover
dose
Heinrich HomeyerSummer School 05 47Ionenstrahllabor Hahn-Meitner-Institut Berlin
Materials Analysis: PIXE - Example
removal of plastic (ca. 1mm) impossible !(destruction of objects)
analysis must look through thislayer
use of 68 MeV protonsenergy loss in 1 mm plastic (ρ ≈ 1 g/cm3): ~ 1 MeVprotons penetrate plastic, but: transmission a problem?after 1 mm:
Fe Kα 6.4 keV 20% Pb Lα 10.5 keV 69%Ag Kα 22.0 keV 93% Pb Kα 75.2 keV 99%
ideal task for high-energy PIXE
0 5depth (mm)
plas
ticco
pper
X-ray
protons
Heinrich HomeyerSummer School 05 48Ionenstrahllabor Hahn-Meitner-Institut Berlin
Materials Analysis: PIXE - Example
5 10 15 20 25 60 70 801
10
100
1000
10000Fe
Kα
Cu
Kα
Cu
Kβ
Zn K
αZn
Kβ Sn
Kα
Sn
Kβ
γ ba
ckgr
ound
Pb
L α
Pb
Lβ
Pb
Lγ Pb
Kα
2 Pb
Kα
1
Pb
Kβ1
Pb
Kβ2
Pb
Sat
ellit
Ag
Kα
Ag
Kβ
Inte
nsity
(arb
. uni
ts)
Energy (keV)5 10 15 20 25 60 70 80
1
10
100
1000
10000Fe
Kα
Cu
Kα
Cu
Kβ
Zn K
αZn
Kβ Sn
Kα
Sn
Kβγ ba
ckgr
ound
Pb
Lα
Pb
Lβ
Pb
Lγ Pb
Kα
2 Pb
Kα
1
Pb
Kβ1
Pb
Kβ2
Pb
Sat
ellit
Ag
Kα
Ag
Kβ
Inte
nsity
(arb
. uni
ts)
Energy (keV)
decorationcentral rivet
example:grave 437
all objects:no gold detectable
K/L X-rays:lead in rivethead
Ionenstrahllabor Hahn-Meitner-Institut Berlin
Chinese bowl: manufacturing date?
both reports based on art historical expertiseindirect dating: identification of pigments
(Cr in green: after 1850)
report 1 (Japan):
500 years old1 Mio. €
report 2 (Berlin):
100 years oldmax. 25 000 €
20 c
m
Heinrich HomeyerSummer School 05 50Ionenstrahllabor Hahn-Meitner-Institut Berlin
Chinese bowl: manufacturing date
green colour no informationyellow colour measured: Zn and Fe, no Sbabsence of Sb is indication for age:after ~1850
4 8 12 16 20 24 28 32
100
1000
Pb
Lα
Pb
Lβ
Pb
Lγ
Fe K
αFe
Kβ
Cu
Kα
Cu
Kβ
Zn K
αZn
Kβ
Cr
Kα
Cr
Kβ
γ Li
nie
Sn
Kα
Sn
Kβ
Sb
Kα
Sb
Kβ
Ba
Kα
yellow colour
Inte
nsity
(arb
. uni
ts)
Energie (keV)4 8 12 16 20 24 28 32
100
1000
Pb
Lα
Pb
Lβ
Pb
Lγ
Fe K
αFe
Kβ
Cu
Kα
Cu
Kβ
Zn K
αZn
Kβ
Cr
Kα
Cr
Kβ
γ Li
nie
Sn
Kα
Sn
Kβ
Sb
Kα
Sb
Kβ
Ba
Kα
white background
Inte
nsity
(arb
. uni
ts)
Energie (keV)
⇒ report 2 could beconfirmed
Heinrich HomeyerSummer School 05 51Ionenstrahllabor Hahn-Meitner-Institut Berlin
Materials Analysis: High-Energy PIXE - Features
PIXE with 68 MeV protons+ analytical depth up to several mm+ large cross section for K lines of heavy elements
+ better separation of heavy elements+ cross section constant over large depth+ small energy loss
⇒ non-destructive analysis+ depth dependant information: intensity ratios+ large and bulky objects can be positioned in front
of the beam
- always radiation from complete material, also nuclear reactions, higher background
Heinrich HomeyerSummer School 05 52Ionenstrahllabor Hahn-Meitner-Institut Berlin
Materials Modifications
Energy transfer– Elektrons– Nuclei
– Lattice/sample– Modifications of
Structures
high electronic excitation10-17 - 10-13 s
heating and particle emission 10-13 - 10-11 s
frozen-in atomic rearrangements> 103 s
Heinrich HomeyerSummer School 05 53Ionenstrahllabor Hahn-Meitner-Institut Berlin
Materials Modification: Single Track Production
irradiation: faster etching rate along trackbest etching ratios for heavy ionsexact determination of pores/cm2
by beam currentexact determination by etching process(time)
form of track depends on etching solution,temperature)0 10 20 30 40 50
0
10
20
30
40
50PET Hostaphan, Au single trackEtched in 1 molar NaOH at 40°
Por
e S
ize
(nm
)
Etching Time (min)
104 105101
102
103
Etc
hing
Rat
io
(Zeff/v)2)
22Ne40Ar51V
∇ 59Co84Kr136Xe
Heinrich HomeyerSummer School 05 54Ionenstrahllabor Hahn-Meitner-Institut Berlin
Materials Modification: Filter ProductionIon Track Membrane
Polymer foil
high frequency magnetic field
horizontal deflection
Gore-Membraneresult: filter with defined structure
required for industrial production: variation beam intensitysmaller than variation in flow-rate
3 µm
Heinrich HomeyerSummer School 05 55Ionenstrahllabor Hahn-Meitner-Institut Berlin
Materials Modification: Foil Irradiation
Track density:10000/cm2 – 500000/cm2
Extreme Stability Requirements
Heinrich HomeyerSummer School 05 56Ionenstrahllabor Hahn-Meitner-Institut Berlin
Materials Modification: Ion Track Technology
counter for red blood particlessingle track, 3 µm < Ø < 5 µm
fuel cells constant charging of battery, lighter with longer live time (mobile in standby: 40 days)
particle filter – encapsuled electro motors – cell ”collection" for microbiology– dust free air in clean rooms
filling with metals, semiconductors .... miniaturised electronic (nano-electronic) nano-wires or nano-tubes
up-to-date research field Cu in ion tracks
Heinrich HomeyerSummer School 05 57Ionenstrahllabor Hahn-Meitner-Institut Berlin
Vertical Nanowire TransistorJ. Chen, R. Könenkamp, Appl. Phys. Lett.82(2003) 4782
Channels from 400-MeV Xe ions are etched and filled with semiconductor
I-V curve
0,0 0,5 1,0 1,50
200
400
600
800
1000
Sour
ce-D
rain
Cur
rent
(nA
)
Source-Drain Voltage (V)
VG=0 V VG=-0.5 V VG=-1.0 V VG=-1.5 V
Perspective: Diameter less than track radii ~ nm
Heinrich HomeyerSummer School 05 58Ionenstrahllabor Hahn-Meitner-Institut Berlin
Ion Track Based Nano Devices
Conducting Ion Track
Gate (poly-Si)
Electrode
(native) OxideSemiconductor
100 nm
AFM tip
Nano-transistor in diamond like carbon
Gate
Source
Drain
PET Foils CuSCN
Insulator
Nano-transistor in etched sandwich foil
Heinrich HomeyerSummer School 05 59Ionenstrahllabor Hahn-Meitner-Institut Berlin
Materials Modifications: Overlapping TracksKlaumünzer 1982Hammering Effect
Heavy IonsE = (1–5)MeV/AHighest LETHigh Total Dose
> 1014/cm2
Low Beam Emittance
A. Gutzmann, S. Klaumünzer et al., Phys. Rev. Lett. 74 (1995) 2256
Ion-beam-induced surface instabilities, ditches and dikes, on glassy Fe40Ni40B20
1015 ions/cm2 1013 ions/cm2
Heinrich HomeyerSummer School 05 60Ionenstrahllabor Hahn-Meitner-Institut Berlin
Materials Modifications: Overlapping TracksExample for ion beam induced self-organisationHigh doses: >1014/cm2
Bolse, Schattat, Feyh, Appl. Phys. A 77/1 (2003) 11
1 µm
a) φ = 1.7 × 1013/cm2
1 µm
b) φ = 3.4 × 1013/cm2
1 µm
d) φ = 8.5 × 1013/cm2
1 µm
f) φ = 7.6 × 1014/cm2
1 µm
c) φ = 5.1 × 1013/cm2
1 µm
e) φ = 1.7 × 1014/cm2
1 µm
Substrate
lamella structure on NiO/SiO2/Si-Wafer
Incidence angle 70° .height ≈ 1 µmwidth ≈ 100 nm260 MeV Kr
Heinrich HomeyerSummer School 05 61Ionenstrahllabor Hahn-Meitner-Institut Berlin
Materials Modification: Overlapping Tracks
Wave length depends on dE/dx (ion)Lighter ion – longer wave length
Rotation of the sample creates nano-towers
Heinrich HomeyerSummer School 05 62Ionenstrahllabor Hahn-Meitner-Institut Berlin
Conclusionfast ions are unique tools for
– research(materials analysis, development of new materials)
– modern technology(filter production, radiation hard electronics)
– Medicine(dosimetry, high precision therapy)
advantages of cyclotrons– variability in ions - even cocktails– energy– beam intensity – Stabilityconsequences:– keeping to schedule– diverse user community
Heinrich HomeyerSummer School 05 63Ionenstrahllabor Hahn-Meitner-Institut Berlin
CoworkersRFQ– W. Busse, O. Engels, B. Martin, A. Schempp, W. Pelzer,
F. HölleringECR-Sources– P. Arndt, J. Röhrich, A. Meseck
Control System – W. Busse, Ch. Rethfeld
Materials Analyses– W. Bohne, A. Denker, J. Röhrich
Modification of Materials– S. Klaumünzer, G. Schiwietz
Tumor Therapy– H. Fuchs, J. Heese, H. Kluge, H. Morgenstern,
I. Reng, Ch. Rethfeld, Thank you for your Attention
Heinrich HomeyerSummer School 05 64Ionenstrahllabor Hahn-Meitner-Institut Berlin
Ion Track Based Nano Devices
Substrate
gate electrode
base electrode
spacerConducting ion track in DLC
conductor
conductor
dot 5 nminsulator 5 nm
insulator 5 nm
AFM tip
8 nm
Field emission: Self aligned gate structure on ion track in diamond like carbon
ta-C
conducting substrate
ta-Cta-C:H
ta-C
ta-C:H
MFM tip
DLCcond. track
quantum-dot with Coulomb-blockade (diamond like carbon multilayer system)
Spin valve structure
Heinrich HomeyerSummer School 05 65Ionenstrahllabor Hahn-Meitner-Institut Berlin
Ionen als Hammer
Anisotrope photonische KristalleVan Dillen 2001Klaumünzer 1982
2009 Schwerionenzyklotron?
Heinrich HomeyerSummer School 05 66Ionenstrahllabor Hahn-Meitner-Institut Berlin
IonenstrahlphysikStrukturforschung
– Erzeugung und – Analyse struktureller Veränderungen
technische Nutzung– Modifikation– Analytik– Strahlentherapie
Forderungen an Forschungsanlage• große Variabilität • hohe Zuverlässigkeit• hohe Stabilität• Reproduzierbarkeit
Heinrich HomeyerSummer School 05 67Ionenstrahllabor Hahn-Meitner-Institut Berlin
Aktivitäten weltweit
KP, IP, SEUH: 70 MeVU: 2-15 MeV/N
C-UUniversitätTexas/USAK=500 Cyclotron
SEU, MA,BT,MM, IP,
Wie ISLH-XEJAERITakasaki/JapanTiara
KP (Injektor),SEU. IP
H: 30 MeVU: bis 1.6 MeV/N
H-UBNLBrookhaven/USA
Tandem
KP, IP, SEUWie ISLH-ULBLBerkeley/USA88“Cyclotron
KP (RIB), IP, SEU, MM
H: bis 80 MeV,Hohe H-Ströme
H-KrUniversitätLouvain la Neuve/Belgien
Cyclone110Cyclone44
KP, SEU, IPH: 50 MeVsonst wie ISL
H-AuUniversitätFinnlandUniv. Jyväskylä
KP, MM, AP0.6-0.9 MeV/N4-13 MeV/N
C-UGanilCEA/CNRS
Caen/Frankreich
CIRIL
KP, MAH 20 MeV;Au 0.9 MeV/N
H-AuUniversitätMünchenTandem
KP MM, SEU
1.5-15 MeV/NC-UHGFDarmstadtGSI (nurUnilac)
MM, MA, ME, RS (SEU)
H: 72 MeV; He-Ne: 1.5-30 MeV/N
H-AuHGFBerlinISLAktivitätenEnergienIonenOrganisationStandortEinrichtung
Heinrich HomeyerSummer School 05 68Ionenstrahllabor Hahn-Meitner-Institut Berlin
Modification of Materials
destroyamorpheziseRauphen surfaces zersetzen
healkristallisieren
glättenkompaktieren
materialabhängig technisch nutzbar
Parameters Ion MassVelocityFluenceDoosIrradiation
Ionenstrahltechniken rechtfertigen sich durch
Anwendungen
Heinrich HomeyerSummer School 05 69Ionenstrahllabor Hahn-Meitner-Institut Berlin
Korrektur (rechnergestützt)Korrektur (rechnergestützt)
Neue Software:Neue Software:
ClipClip--SollpositionenSollpositionen(Bestrahlungsplan)(Bestrahlungsplan)
ClipClip--ErkennungErkennung(Röntgenaufnahme)(Röntgenaufnahme)
Vergleich beider AnordnungenVergleich beider Anordnungen
KorrekturvorschlagKorrekturvorschlag
2 Patientenlagerung
Heinrich HomeyerSummer School 05 70Ionenstrahllabor Hahn-Meitner-Institut Berlin
AufwandAufwand
Einstellungen 10 - 15 (max. 40)
Zeitaufwand 10 min (max. ½ h)
Anteile:Anteile: -- Herantasten bei Herantasten bei komplexen Korrekturenkomplexen Korrekturen-- Eingehen auf Eingehen auf Fähigkeit zur Fähigkeit zur FixationFixation-- Nachjustieren der Nachjustieren der LidhalterLidhalter-- Unruhe, Unruhe, ErschöpfungErschöpfung, Schmerzen, Schmerzen
2 Patientenlagerung