irrational economic decision making in schizophrenia
DESCRIPTION
Kyongsik Yun, Yang Tae Kim, Jaeseung Jeong. “Irrational Economic Decision-Making in Schizophrenia: Evidence from the Ultimatum Game”, Korean Neuropsychiatric Association. Seoul, Korea, October 23 – 24, Oral PresentationTRANSCRIPT
![Page 1: Irrational Economic Decision Making in Schizophrenia](https://reader034.vdocuments.net/reader034/viewer/2022051609/54633eedb1af9f7d228b539b/html5/thumbnails/1.jpg)
Irrational Economic Decision Making in Schizophrenia:
Evidence from the Ultimatum GameEvidence from the Ultimatum GameKorean Neuropsychiatric Association
2008.10.23, 03:25p.m.
Kyongsik Yun, Ph.D. CandidateKyongsik Yun, Ph.D. CandidateBio and Brain Engineering
![Page 2: Irrational Economic Decision Making in Schizophrenia](https://reader034.vdocuments.net/reader034/viewer/2022051609/54633eedb1af9f7d228b539b/html5/thumbnails/2.jpg)
Questions to be asked• Is the Ultimatum game behavior of schizophrenia
different from that of normal controls?
• Does time frequency analysis of EEGs show impaired decision making in schizophrenia?
• Does phase synchronization of EEGs show impaired decision making in schizophrenia?
2
![Page 3: Irrational Economic Decision Making in Schizophrenia](https://reader034.vdocuments.net/reader034/viewer/2022051609/54633eedb1af9f7d228b539b/html5/thumbnails/3.jpg)
3
![Page 4: Irrational Economic Decision Making in Schizophrenia](https://reader034.vdocuments.net/reader034/viewer/2022051609/54633eedb1af9f7d228b539b/html5/thumbnails/4.jpg)
What are the temporal dynamics of social interaction?
proposer responder
4
![Page 5: Irrational Economic Decision Making in Schizophrenia](https://reader034.vdocuments.net/reader034/viewer/2022051609/54633eedb1af9f7d228b539b/html5/thumbnails/5.jpg)
What are the temporal dynamics of social interaction?
proposer responder
1. Make an offer: 9:1(send emotional cue)(send emotional cue)Reward anticipation (NAcc)
5
![Page 6: Irrational Economic Decision Making in Schizophrenia](https://reader034.vdocuments.net/reader034/viewer/2022051609/54633eedb1af9f7d228b539b/html5/thumbnails/6.jpg)
What are the temporal dynamics of social interaction?
proposer responder
1. Make an offer: 9:1(send emotional cue) 2. Conflict btwn emotion & cognition
ACC, Ins, dlPFC activation (interaction)
responder
(send emotional cue)Reward anticipation (NAcc)
ACC, Ins, dlPFC activation (interaction)
6
![Page 7: Irrational Economic Decision Making in Schizophrenia](https://reader034.vdocuments.net/reader034/viewer/2022051609/54633eedb1af9f7d228b539b/html5/thumbnails/7.jpg)
What are the temporal dynamics of social interaction?
proposer responder
1. Make an offer: 9:1(send emotional cue) 2. Conflict btwn emotion & cognition
ACC, Ins, dlPFC activation (interaction)
responderresponder
(send emotional cue)Reward anticipation (NAcc)
ACC, Ins, dlPFC activation (interaction)3. Make a decision (reject: Ins)
7
![Page 8: Irrational Economic Decision Making in Schizophrenia](https://reader034.vdocuments.net/reader034/viewer/2022051609/54633eedb1af9f7d228b539b/html5/thumbnails/8.jpg)
What are the temporal dynamics of social interaction?
proposer responder
1. Make an offer: 9:1(send emotional cue) 2. Conflict btwn emotion & cognition
ACC, Ins, dlPFC activation (interaction)
responderresponderproposer
(send emotional cue)Reward anticipation (NAcc)
ACC, Ins, dlPFC activation (interaction)
4. Reward prediction error
3. Make a decision (reject: Ins)
8
![Page 9: Irrational Economic Decision Making in Schizophrenia](https://reader034.vdocuments.net/reader034/viewer/2022051609/54633eedb1af9f7d228b539b/html5/thumbnails/9.jpg)
Previous studies:
emotion vs. cognition
Sanfey et al. Science, 2003 9
![Page 10: Irrational Economic Decision Making in Schizophrenia](https://reader034.vdocuments.net/reader034/viewer/2022051609/54633eedb1af9f7d228b539b/html5/thumbnails/10.jpg)
What are the neural mechanisms of human decision making in the context of emotion and cognition?
Anterior dlPFC Anterior insula
dlPFC
ACC10
![Page 11: Irrational Economic Decision Making in Schizophrenia](https://reader034.vdocuments.net/reader034/viewer/2022051609/54633eedb1af9f7d228b539b/html5/thumbnails/11.jpg)
Time line for a single round of the Ultimatum Game
Subject decides
6 sec 6 sec 6 sec x sec 6 sec
+ He gets $9You get $1 Accept Reject He gets $0
You get $0
x: Time continues until the subject decides.
RevealFixation
RevealPartner
RevealOffer
RevealOptions
RevealOutcome
11
![Page 12: Irrational Economic Decision Making in Schizophrenia](https://reader034.vdocuments.net/reader034/viewer/2022051609/54633eedb1af9f7d228b539b/html5/thumbnails/12.jpg)
Behavioral results from the Ultimatum Game
80
100
Schizophrenic
Control
20
40
60
Ac
cep
tan
ce r
ate
s (
%)
*
5:5 7:3 8:2 9:1
0
Offer
These are the offer acceptance rates averaged over all trials. Each of schizophrenia patients and normal controls saw three $5:$5 offers, two $7:$3 offers, two $8:$2 offers, and three $9:$1 offers from human partners (10 offers in total). 12
![Page 13: Irrational Economic Decision Making in Schizophrenia](https://reader034.vdocuments.net/reader034/viewer/2022051609/54633eedb1af9f7d228b539b/html5/thumbnails/13.jpg)
No difference between schizophrenia and controls was found in total earnings and reaction times.
13
![Page 14: Irrational Economic Decision Making in Schizophrenia](https://reader034.vdocuments.net/reader034/viewer/2022051609/54633eedb1af9f7d228b539b/html5/thumbnails/14.jpg)
Group average of induced spectral power for all electrodesschizo
Overall power is decreased in schizo.Especially when accepting the offer -> fairness valuation deficiency
normal
14
![Page 15: Irrational Economic Decision Making in Schizophrenia](https://reader034.vdocuments.net/reader034/viewer/2022051609/54633eedb1af9f7d228b539b/html5/thumbnails/15.jpg)
Topography of event related spectral power for each condition
Schizo accept
Normal accept
Schizo reject
-800~400ms
Normal reject
-400~0ms 0~400ms 400~800ms
SD
15
![Page 16: Irrational Economic Decision Making in Schizophrenia](https://reader034.vdocuments.net/reader034/viewer/2022051609/54633eedb1af9f7d228b539b/html5/thumbnails/16.jpg)
Group average of time series of event related spectral power for all electrodes and each decision in gamma
frequency range (30~50Hz)schizo
Lower overall power in schizo.Power change is not stable -> meaning?? regional communication is impaired.
normal
16
![Page 17: Irrational Economic Decision Making in Schizophrenia](https://reader034.vdocuments.net/reader034/viewer/2022051609/54633eedb1af9f7d228b539b/html5/thumbnails/17.jpg)
Phase synchronization analysis
Lachaux et al. 1999 17
![Page 18: Irrational Economic Decision Making in Schizophrenia](https://reader034.vdocuments.net/reader034/viewer/2022051609/54633eedb1af9f7d228b539b/html5/thumbnails/18.jpg)
schizo
Long range
Group average of phase synchrony for all electrodes
normal
Long range synchronization and communication is impaired in schizoEspecially when accepting the offer -> fairness valuation deficiency
18
![Page 19: Irrational Economic Decision Making in Schizophrenia](https://reader034.vdocuments.net/reader034/viewer/2022051609/54633eedb1af9f7d228b539b/html5/thumbnails/19.jpg)
Summary• Is the Ultimatum game behavior of schizophrenia
different from that of normal controls?– Yes. Abnormally accept. – Fairness valuation deficiency? Or economically rational?– Fairness valuation deficiency? Or economically rational?
• Does time frequency analysis of EEGs show impaired decision making in schizophrenia?– Yes. Lower overall power amplitude. – Especially when accepting the offer -> fairness valuation deficiency
• Does phase synchronization of EEGs show impaired decision making in schizophrenia?– Yes. Lower phase synchrony.– Especially when accepting the offer -> fairness valuation deficiency
19
![Page 20: Irrational Economic Decision Making in Schizophrenia](https://reader034.vdocuments.net/reader034/viewer/2022051609/54633eedb1af9f7d228b539b/html5/thumbnails/20.jpg)
Acknowledgments
• Jaeseung Jeong, Ph.D.• Jaeseung Jeong, Ph.D.– Advisor, Brain Dynamics Lab, KAIST,
• Dongil Chung– Ph.D. candidate, Brain Dynamics Lab, KAIST
Yang Tae Kim, M.D.• Yang Tae Kim, M.D.– Bugok National Hospital
20