ishr xxii world congress...ishr xxii world congress buenos aires - argentina table of contents ishr...

"Unraveling the mysteries of the heart at the rhythm of tango”

APRIL 18-21, 2016 • Buenos Aires - Argentina

ISHR XXII WORLD CONGRESSInternational Society for Heart Research

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FOYER(speaker ready room)

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JUAN PABLO IIJUAN PABLO II(b)

FoyerJUAN PABLO II

Room 204

Welcome to the

ISHR XXII WORLD CONGRESSInternational Society for Heart Research

APRIL 18-21, 2016 • Buenos Aires - Argentina

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ISHR XXII WORLD CONGRESSBuenos Aires - Argentina

TABLE OF CONTENTS

ISHR COMMITTEE 4

ISHR SECTIONS 5

IMPORTANT DATES & DEADLINES 6

MAIN ATTRACTIONS 6 to 7

WELCOME LETTERS 8 to 11

SYMPOSIA LISTED BY THEME 12 to 20

PROGRAM BY DAY 21 to 38

ECI PRE-CONGRESS 21 - 22

MAIN CONGRESS 22 - 38

MAP OF THE VENUE’S SURROUNDINGS 33

PROGRAM AT A GLANCE 34 to 35

ECI SOCIAL MEETING & GALA DINNER 36

TUESDAY POSTER SESSIONS 39 to 45

WEDNESDAY POSTER SESSIONS 45 to 51

THURSDAY POSTER SESSIONS 51 to 57

SYMPOSIUM SPEAKERS 58 to 59

AUTHOR INDEX 60 to 67

NOTES 68

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LOCAL SCIENTIFIC PROGRAM COMMITTEE

Martín Vila Petroff, PhDAlicia Mattiazzi, MD, PhDCecilia Mundiña-Weilenmann, PhDJulieta Palomeque, MD, PhDElena Lascano, PhDAlejandro Aiello, PhD

INTERNATIONAL SCIENTIFIC PROGRAM COMMITTEE

Rick Moss, PhDFabio di Lisa, MDTetsuji Miura, MD, PhDIssei Komuro, MD, PhDJeffrey Robbins, PhDDavid Eisner, PhDLivia Hool, PhDAlicia Mattiazzi, MD, PhDJeffery Molkentin, PhDGerald Dorn, MDThomas Thum, MD, PhDThomas Eschenhagen, MDKeiichi Fukuda, MD, PhDGary Lopaschuk, PhDRong Tian, MD, PhDYi Zhu, MD

ECI COMMITTEE

Sarah Franklin, PhDKate Weeks, PhDHelena Viola, PhDKimberley Mellor, PhDTania Paglia, PhDJoseph Burgoyne, PhDStephan Lange, PhDCatherine Makarewich, PhDCarlos A. Valverde, PhDLi Zhang, PhDLiming Yang, PhDMotoaki Sano, PhDHiroshi Akazawa, PhDFaculty Advisors:Thomas Thum, MD, PhDFederica Del Monte, PhD

ISHR EXECUTIVE COMMITTEE 2013-2016

PresidentDr. METIN AVKIRANCardiovascular Division, King's College London. The Rayne Institute, St. Thomas' HospitalLondon SE1 7EH, UKTel: +44-20-7188-3899Fax: +44-20-7188-3902E-mail: [email protected]

Secretary GeneralDr. RICHARD MOSSRennebohm Research ProfessorSchool of Medicine and Public Health. University of Wisconsin-Madison WI 53705, USATel: +1-608-265-0523Fax: +1-608-265-0522Email: [email protected]

Past-PresidentDR. MASATSUGU HORIOsaka Medical Center for Cancer and Cardiovascular Diseases1-3-3 Nakamichi Higashinari-kuOsaka 357-8511, JAPANTel: +81-6-6972-1181Fax: +81-6-6981-7050Email: [email protected]

President-ElectDr. ELIZABETH MURPHYNHLBI, NIH 7170 Rivers Edge RdColumbia, MD 21044, USATel: +1-919-451-8737Email: [email protected]

TreasurerDr. ASA GUSTAFSSONSkaggs School of Pharmacy & Pharmaceutical SciencesUniv of California, San DiegoLa Jolla, California, USA92093-0758Tel: +1-828-822-5569Fax: +1-858-822-7558Email: [email protected]

Council Member:Dr. MARK SUSSMANSan Diego State Univ Heart InstituteDept of Biology, LS 4265500 Campanile DrSan Diego, California 92182, USATel: +1-619-594-2983Fax: +1-619-594-2610Email: [email protected]

Heart News and Views Editor (ex officio)Dr. LESLIE ANDERSON LOBAUGHExecutive Secretary, ISHR3711 Lochn'ora ParkwayDurham, North Carolina 27705,USA.Tel/Fax: +1-919-493-4418Email: [email protected]

J Mol Cell Cardiol EditorDr. DAVID EISNERBHF Professor of Cardiac Physiology. Unit of Cardiac Physiology, Univ. of Manchester3.18 Core Technology Facility46 Grafton St.Manchester M13 9NT, UK Tel: +44-161-275-2702 Fax: +44-161-275-2703 E-mail: [email protected]

2016 ISHR WORLD CONGRESSORGANIZING COMMITTEEChair: Martín Vila Petroff, PhDCo-Chair: Alejandro Aiello, PhDMembersAlicia Mattiazzi, MD, PhDCecilia Mundiña-Weilenmann, PhDJulieta Palomeque, MD, PhDIrene Ennis, MD, PhDElena Lascano, PhDCarlos A. Valverde, PhDLuis Gonano, MD, PhDVerónica De Giusti, MD, PhDSecretary: Constanza Morell, HRIT: Ramiro F. Martínez Quiroga

ISHR XXII WORLD CONGRESS • APRIL 18-21, 2016Buenos Aires - Argentinawww.ishrbuenosaires2016.org.ar

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ISHR SECTIONS

AUSTRALASIAN

Section PresidentLIVIA HOOL

Section Member SecretaryCOLLEEN THOMAS

Finance SecretarySALVATORE PEPE

Section Past-PresidentLEA M. DELBRIDGE

CHINESE

Section PresidentYI ZHU

Section SecretaryMING M XU

Section TreasurerLILING F. WU

Section Vice PresidentQI CHEN

Section Vice PresidentHUANG TIAN F. YANG

Section Vice PresidentYOU YI F. ZHANG

Section Past-PresidentRUTAI HUI

EUROPEAN

Section PresidentDAVID EISNER

SecretaryDEREK HAUSENLOY

TreasurerJOLANDA VAN DER VELDEN

Section Past-PresidentPÉTER FERDINANDY

Section President-ElectRODOLPHE FISCHMEISTER

INDIAN

Section PresidentK.K. TALWAR

General SecretaryS.K. MAULIK

Joint SecretaryAJAY BAHL

Joint SecretaryRAKESH YADAV

Section TreasurerS SETH

Section Vice PresidentBALRAM BHARGAVA

Section Vice PresidentCHANDRASEKHARAN C. KARTHA

National AdvisorY.K. GUPTA

International AdvisorS.K. GUPTA

JAPANESE

Section PresidentKEIICHI FUKUDA

Secretary GeneralTOYOAKI MUROHARA

Section TreasurerHIROYUKI TSUTSUI

Section Past-PresidentISSEI KOMURO

Section SecretaryTOYOAKI MUROHARA

LATIN AMERICAN

Section PresidentMARTIN VILA PETROFF

Section SecretaryCARLOS A. VALVERDE

Section TreasurerJULIETA PALOMEQUE

Section Past-PresidentJOSE G. MILL

NORTH AMERICAN

Section PresidentGARY D. LOPASCHUK

Section Member SecretarySUSAN HOWLETT

Section Recording SecretaryTHOMAS M. VONDRISKA

Section TreasurerEVANGELIA KRANIAS

Section Past-PresidentELIZABETH MURPHY

Section President-ElectPEIPEI PING

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IMPORTANT DATES & DEADLINES

September 28, 2015: Registration and Abstract Submission openDecember 15, 2015: Abstract submission deadline to be considered for oral presentationDecember 15, 2015: Deadline for Young Investigator Travel AwardsDecember 15, 2015: Deadline for Registration GrantsDecember 15, 2015: Deadline for Richard J Bing Award for Young Investigator applicationsFebruary 1, 2016: Early Registration Discount endsMarch 1, 2016: Abstract submission ends

OPENING CEREMONY

Monday 18th 2:30 PM, Juan Pablo II Conference Room. Welcome address by the ISHR President and the Congress chair followed by the Keith Reimer Distinguished Lecture Award.

FISHR DINNER

Wednesday 20th 8 PM: ISHR Fellows, please join us for a relaxed get together at: Estilo Campo, Alicia Moreau de Justo 1840, Buenos Aires. www.estilo-campo.com.ar Meeting Point: Registration desk (ground floor) / 19:45 h.

ISHR GALA DINNER

Thursday 21st 9 PM: To close our congress with a flourish, please join us at the Gala Dinner at Piazzolla Tango Theatre for a typical Argentinean Tango Show (www.piazzollatango.com). Those who wish to learn some tango dancing skills can go to the theatre 1 hour in advance and take free tango lessons. Free transport from and to Piazzolla Tango will be provided. Buses will depart from Hotel Madero (Rosario Vera Peñaloza 360 Puerto Madero) at 7.30 PM. Tickets are available through the registration site and include a 3 course meal with wine followed by a professional tango show. Delegates and registered accompanying persons pay the discounted fee of US$40. Each delegate can register to bring Guests for US$100 each. Tickets are limited and will be available on a first come first serve basis.

PLENARY SESSIONS (Juan Pablo II Conference Room)

thNobel Laureate Lecture: Wednesday 20 April, 11:00 hs.ROBERT J. LEFKOWITZ, Duke University, USA. “Seven Transmembrane Receptors”.

stPeter Harris Distinguished Scientist Award: Thursday 21 April, 15:00 hs. DONALD M. BERS, UC-Davis, USA. “Calmodulin and CaMKII in heart failure and arrhythmias”.

thResearch Achievement Award: Tuesday 19 April, 11:00 hs. HEPING “PEACE” CHENG, Peking University, Chine.“Protons trigger mitochondrial flashes for ATP homeostasis in the heart”.

thKeith Reimer Distinguished Lecture Award: Monday 18 April, 15:00 hs. RODOLPHE FISCHMEISTER, INSERM, France.“Cyclic nucleotide microdomains and phosphodiesterases: Small sinks with smart drains can do a lot!”.

stJanice Pfeffer Distinguished Lecture Award: Thursday 21 April, 12:00 hs. EDWARD LAKATTA, NIA, NIH, USA. “The heartbreak of aging viewed from the angiotensin II-remodeled arterial wall”.

6 ISHR XXII WORLD CONGRESS • APRIL 18-21, 2016Buenos Aires - Argentinawww.ishrbuenosaires2016.org.ar

stPresident’s Distinguished Lecture Award: Thursday 21 April, 8:30 hs. THOMAS ESCHENHAGEN, University of Hamburg, Germany. "Modelling heart disease in the dish - chances and challenges".

thOutstanding Investigator Award: Monday 18 April, 18:15 hs. JOHANNES BACKS, University of Heidelberg, Germany. “Cardiac Epigenetics - From mechanisms to translation”

th2016 ISHR Distinguished Leader Award: Wednesday 20 April, 11:00 hs. SALVATORE PEPE, Murdoch Childrens Research Institute, Australia.

RICHARD J. BING YOUNG INVESTIGATOR AWARD thJuan Pablo II Conference Room, Tuesday 19 April, 13.30 hs.

Many thanks to members of the Bing Award Selection Committee who assisted with the initial review of applicants: Hossein Ardehali, Lea Delbridge, Federica del Monte, David Eisner, Thomas Eschenhagen, Rodolphe Fischmeister, Asa Gustafsson, Derek Hausenloy, Masatsugu Hori, Gary Lopaschuk, Yoshihiko Saito, Issei Komuro, Barbara McDermott, Toyoaki Murohara, Salvatore Pepe, Mark Sussman, Thomas Thum, Jolanda van der Velden, Martín Vila Petroff.

Judging panel:CHAIR: David EisnerPANEL: Lea Delbridge, Tish Murphy, Rodolphe Fischmeister, Asa Gustafsson, Issei Komuro, Gary Lopaschuk, Jolanda van der Velden, Martín Vila Petroff.

Finalists 2016 (in alphabetical order)

Kiyotake Ishikawa

Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, USA.“Intratracheal gene delivery of SERCA2a ameliorates chronic pulmonary hypertension in a large animal preclinical model”.

Victoria Mascetti

Dept of Surgery and British Heart Foundation Centre of Regenerative Medicine, University of Cambridge, Cambridge, UK.

“Human-mouse chimerism validates human stem cell pluripotency”.

Gaetano Santulli

Wu Center for Molecular Cardiology, College of Physicians and Surgeons of Columbia University, New York, USA.

“Distinct roles of intracellular calcium release channels in cardiac and vascular remodeling”.

Helena Viola

School of Anatomy, Physiology and Human Biology, The University of Western Australia, Perth, Australia.2+“The role of the L-type Ca channel in altered metabolic activity in a murine model of hypertrophic cardiomyopathy”.

ISHR POSTER AWARDS

Poster Award Committee

CHAIRS: Hossein Ardehali, Livia Hool, Cecilia Mundiña-Weilenmann.

JUDGES: Paolo Bernardi, Donald Bers, Burns C. Blaxall, Joan Heller Brown, Fabio Di Lisa, Gerald Dorn, Roberta Gottlieb, Asa B. Gustafsson, Roger Hajjar, Steven Houser, Timothy J. Kamp, Richard Kitsis, Bjorn Knollmann, Walter Koch, David Lefer, Gary D. Lopaschuk, Tetsuji Miura, Brian O'Rourke, Jeffrey Robbins, Michael N. Sack, Junichi Sadoshima, Christian Schulze, Ajay Shah, Mark A. Sussman.

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Dear colleagues,

On behalf of the Local Organizing Committee of the XXII World Congress of the ISHR and of the Latin American Section of the ISHR we are delighted to welcome you to Buenos Aires to participate in what we expect to be a memorable Congress at the wonderful location of Puerto Madero.

The International Scientific Program Committee together with the Local Scientific Program Committee have put together an exciting and provocative scientific program covering a range of topics with an integral perspective, with the aim of establishing a real syncytium between basic research and clinical practice and between cardiovascular health and disease. We believe that this approach will give our attendees the clues to where the future of our field is heading. This year's congress has a total of 33 symposia, each composed of 4 prestigious invited speakers and 1 short talk selected from the abstracts submitted by early career investigators. We will also have 6 Award Lectures given by exceptional scientist that have made outstanding contributions to our field. We are also delighted to announce that our Congress's main attraction will be the Nobel Laureate Lecture delivered by Dr. Robert Lefkowitz. Not less important is what we think in the future will be considered a hallmark of all ISHR meetings, that is, to have an early career investigator pre-congress meeting. These events, introduced successfully in San Diego 2013, are specifically designed to highlight the interests and professional needs of young investigators and to encourage their transit along the scientific path.

Another aspect of this congress which we hope will be outstanding is the programmed social activity. Buenos Aires has all the ingredients to fulfill this project, the city is vibrant with culture and attractions, the people are warm hearted and the weather in April is usually enjoyable. We have scheduled a Gala Dinner with Tango Show at the historic Güemes Gallery which is a must see while you're in Buenos Aires. We also encourage you to take advantage of the unique location of the Madero district which is walking distance from the typical neighborhood of San Telmo and only minutes away from the station where you can catch a ferry and sail the La Plata river delta. We also invite you to the Opening Cocktail which we are sure will be the perfect scenario to ensure the successful start of this congress.

Finally, we would like to specially thank Rick Moss, Tish Murphy and Metin Avkiran for their permanent advice and help during the planning and execution of the Congress. We also express our gratitude to Leslie Anderson Lobaugh, Constanza Morell and Asa Gustafsson for their exceptional work and tireless dedication to secure the success of this congress.

Please join us to share stimulating science and ISHR collegial atmosphere in an attempt to unravel together the mysteries of the heart at the rhythm of tango!!!

We look forward to being your hosts and giving you the “Buenos Aires Experience”

Martín Vila Petroff, PhDChair XXII World Congress of the ISHR

ISHR


Dear colleagues,

As I have noted previously in the ISHR newsletter Heart News & Views, there is no shortage of associations, societies and scientific conferences with a cardiovascular focus (basic, clinical or both) and, indeed, many ISHR members also participate in the activities of other organizations. So what makes the ISHR unique and allows it to prosper, despite the challenges associated with being a federation of multiple regional sections spread across the world, with little direct subscription income and no full-time employees, in a sphere that is occupied by much wealthier, and perhaps more “professional”, organizations? I believe the answer lies in the nature and scope of our meetings, particularly our triennial World Congress.

The World Congress is undoubtedly the ISHR's premier event and is hosted by local organizers belonging to different ISHR sections, in keeping with the global and inclusive nature of our Society. Of course, what distinguishes the ISHR is not just the varied (and some might say exotic!) locations of its World Congress, but also the unique nature of each meeting, with strong cultural elements and local flavour (often literally) complementing outstanding science, in a relaxed and friendly environment. Remarkably, all this is achieved through the volunteer efforts of the local organizers, with support from the ISHR Officers and Council, who invariably put their hearts and souls into creating an event that is truly memorable for both the science and the setting.

With that preamble, it is my great pleasure to welcome you to the XXII ISHR World Congress in Buenos Aires, hosted by Martin Vila Petroff and colleagues from Centro de Investigaciones Cardiovasculares, La Plata. This dedicated team of loyal ISHR members have worked tirelessly on hosting the ISHR World Congress under the auspices of the Latin American Section for the very first time, and I have no doubt that the XXII World Congress will maintain the tradition of scientific excellence, cultural enrichment and outstanding hospitality that has been established by so many previous Congresses. Buenos Aires is often referred to as the “Paris of South America” for its architecture and rich heritage, and the city and its people are said to combine European sensibilities with Latin American passion – add to that heady mixture the enthusiasm and energy of Martin and his local organizing team and the outstanding quality of the program that has been put together by the International Scientific Program Committee under the chairmanship of Rick Moss, then I think we are assured of a wonderful few days ahead of us.

My sincerest thanks go to Martin and Rick and their teams, to Sarah Franklin and other members of the Early Career Investigator committee, to David Eisner and colleagues who have organized the Richard J Bing Young Investigator Award competition, to the members of the ISHR Executive Committee and especially Leslie Lobaugh, our Executive Secretary, for their tireless efforts, and finally to all ISHR members who have made key contributions, in particular through their participation as speakers, poster presenters/discussants and delegates. I wish everyone a hugely successful and enjoyable Congress.

Metin Avkiran, PhD DscPresident, ISHR

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Richard L. Moss, PhDSecretary General, ISHR

Welcome to the 2016 World Congress of the International Society for Heart Research!

The ISHR is among the leading societies internationally dedicated to understanding the basis for inherited and acquired diseases of the heart and vascular system, with the ultimate goal of improving clinical approaches to treatment and prevention of disease. This year's World Congress promises to report new advances in our understanding of determinants of cardiac health and disease. Nearly 170 speakers from our regional sections will make oral presentations addressing the primary themes of the meeting:

· Cardiac Regulation: Beyond the Genome · Cardiac Metabolism · Mechanisms and Therapeutic Targets for Arrhythmias · New Insights into Cardiac Dysfunction · Mechanisms of Cardioprotection and Injury · Regenerative Medicine for Heart Diseases · Signaling in Cardiac Disease · Translation from Cardiac Research to Therapies

The Scientific Program Committee in collaboration with the Local Organizing Committee has drafted a schedule of 33 symposia that ensures that these themes are carried through the three days of the Congress. The scientific program notably features participation by investigators at early career stages: a half-day pre-Congress session involving oral presentations by Early Career Investigators, symposium presentations by faculty at ranks equivalent to assistant professor, and co-chairing of all the symposia that comprise the meeting. The schedule has been tailored to ensure that poster sessions occur during “prime time” each day. The outstanding poster from each of the three sessions selected by the judges will be recognized by a poster prize to the primary author.

On behalf of the ISHR, I extend deepest appreciation to the Scientific Program Committee and the Local Organizing Committee for their thoughtful and dedicated work in bringing this World Congress to fruition. I especially thank Martin Vila Petroff and Alejandro Aiello, Chair and Co-Chair of the Local Organizing Committee for their leadership in hosting this meeting in Buenos Aires and for their relentless pursuit of excellence in organizing the meeting. Dr. Carlos Valverde has also made essential contributions to final preparations for the meeting. The work involved in this undertaking is demanding and can at times be consuming, but through it all, Martin and Alex and their organizing committee have worked tirelessly to ensure that the World Congress is compelling and memorable.

To reap the full benefit of attending the World Congress, I encourage you to take part in the General Assembly and organized social activities as a means to learn more about the ISHR and to meet colleagues from around the globe.

On behalf of the organizing committees, I wish you a very successful meeting! Thank you for your commitment to the missions and programs of the ISHR.


Dear colleagues,

I would like to give you a warm welcome to Buenos Aires. I am sure that you will find excellent science in this Congress, as usual in ISHR World Meetings; but I am also sure that you will find a beautiful and eclectic city to discover.

After a frustrated first foundation in 1536, Buenos Aires was definitely founded in 1580 by Don Juan de Garay, a Spanish conqueror that led his old galleons towards the muddy coast of a brown river, the world's widest river, “Río de la Plata”. Don Juan decided to build the new city along the riverfront, close to where the presidential palace, “Casa Rosada” (pink house), is located today, one of the many must-see spots. “Casa Rosada” is located in front of “Plaza de Mayo” (May Square) and the Buenos Aires Cathedral, where Archbishop Jorge Bergoglio, now Pope Francis, delivered mass until appointed Head of the Catholic Church. A few blocks south of May Square you can go relic hunting in the colonial neighborhood of San Telmo.

Walking west from May Square, on Avenida de Mayo, try a coffee with medialunas in the historic Café Tortoni. Just keep walking up to the crossroad with 9 de Julio Avenue, to have a glimpse of the “Obelisco”, another icon of this city. This monument is located at the crossroad of 9 de Julio and Corrientes Ave, famous for its theatres, pizza places and bookstores; the avenue that never sleeps! A few blocks from there you will find the Colón Theater, the Opera House, a magnificent palace.

The Congress venue, the UCA Convention Centre, is located in the district of Puerto Madero, a modern area of the city which harbors the latest architectural trends, the best restaurants and bars of Buenos Aires and is only a few blocks away from the Ecological Reserve, a big green area, ideal for an afternoon stroll to enjoy local flora and wild life or to do birdwatching in the very heart of the city!

Another interesting place to visit is the precious Recoleta cemetery, located in the ritzy Recoleta neighborhood, which is the resting place for many notable political figures and elites in Argentine history, including Evita Perón.If you want to catch the spirit of the immigrant's life by the turn of the 20th century and see the mythic birthplace of Tango, you must visit Caminito, in the neighborhood of “La Boca”. And talking about Tango, the music that hallmarks Buenos Aires, please remember that on April 21st we will close the Congress with an evening Gala Dinner and tango show at historic Güemes Gallery. It is said you haven't been in Buenos Aires if you haven't seen a Tango Show, so we encourage you to reserve your tickets for this unique opportunity which will include transfer from the Convention Centre to Güemes Gallery, tango lessons, 3 course meal with wine and an exclusive tango show featuring the music of Astor Piazzola, the pioneer of modern Tango. His work revolutionized the traditional tango into a new style known as “nuevo tango” incorporating elements from jazz and classical music, exemplified by the well-known “Libertango”, performed by Grace Jones in Roman Polanski movie “Frantic”.

Welcome again to the ISHR World Meeting; you are formally invited to combine the passion for unveiling the secrets of the heart with the fun of discovering Buenos Aires, a South-American pearl that deserves to be enjoyed.

“A mí se me hace cuento que empezó Buenos Aires, la juzgo tan eterna como el agua y como el aire (Hard to believe Buenos Aires had any beginning. I feel it to be as eternal as air and water)”.

Jorge Luis Borges

ISHR Alejandro Aiello, PhDCo-chair XXII World Congress of the ISHR

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Cardiac Dysfunction

CANON SYMPOSIUM: CARDIAC HYPERTROPHY AND FAILURE (Symposium 4)Chair: Matt Hori, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka. Japan.Co-chair: Delaine Ceholski, Icahn School of Medicine at Mount Sinai, Manhattan, USA.

1. Cardiac DNA damage causes heart failure. Issei Komuro, The University of Tokyo, Tokyo, Japan.

2. Development of gene delivery tools targeting PI3K-regulated mRNAs and microRNAs to improve function of the failing heart. Julie McMullen, Baker IDI Heart and Diabetes Institute, Melbourne, Australia.

3. Natriuretic Peptide System: Its role in heart failure, and acute myocardial infarction. Yoshihiko Saito, Nara Medical University, Nara, Japan.

4. Exercise training in heart failure. Patricia Brum, University of Sao Paolo, Sao Paolo, Brazil.

5. Oral Abstract: Modelling dilated cardiomyopathy-linked mutations in phospholamban using gene editing in iPS-derived cardiomyocytes.

Delaine Ceholski, Mount Sinai Hospital, New York, USA.

NOVEL MECHANISMS IN CARDIOMYOPATHY (Symposium 8)Chair: Richard L. Moss, University of Wisconsin, Madison, Madison, USA.Co-chair: Sakthivel Sadayappan, Loyola University, Chicago. Illinois, USA.

1. Autophagy-lysosomal pathway in inherited sarcomeric cardiomyopathies. Lucie Carrier, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

2. Proteotoxicity: A common pathway in cardiac and neurodegenerative disease. Jeffrey Robbins, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

3. Proteotoxic signaling pathways. Marco Sandri, Venetian Institute of Molecular Medicine, Padova, Italy.

4. Hypertrophic cardiomyopathy mutations expressed in iPSCs. J. Carter Ralphe, University of Wisconsin-Madison, Madison, USA.

5. Oral Abstract: A pathogenic MYBPC3 25-bp polymorphic variant causes hypertrophic cardiomyopathy in South Asian descendants.

Sakthivel Sadayappan, Loyola University - Chicago, Illinois, USA.

OXIDATIVE STRESS IN HEART FAILURE (Symposium 10)Chair: Derek Laver, University of Newcastle, New South Wales, Australia.Co-chair: Sarah Franklin, University of Utah, Salt Lake City, Utah, USA.

1. NADPH oxidase isoforms in cardiac stress and failure. Ajay Shah, Cardiovascular Division, King's College, London, United Kingdom.

2. Nitric Oxide and Oxidative Stress in Heart Failure. David Lefer, Louisiana State University, New Orleans, Louisiana, USA.

3. Bioenergetic control of heart function. Pierre Domingues Dos Santos, Universite de Bordeaux, Bordeaux, France.

4. Sources and Targets of Mitochondrial ROS in Heart Failure. Fabio Di Lisa, University of Padova, Padova, Italy.

5. Oral Abstract: Role of miRNA-33a in Dilated Cardiomyopathy. Anupam Mittal, Jawaharlal Nehru University, New Delhi, India.

INHIBITING NODAL SIGNALING PATHWAYS AS NOVEL APPROACHES TO TREATING HEART FAILURE (Symposium 16)Chair: John Solaro, University of Illinois, Illinois, USA.Co-chair: Przemyslaw Gorski, Icahn School of Medicine at Mount Sinai, Manhattan, New York, USA.

1. Targeting ERK signaling: a double-edged sword?. Kristina Lorenz, University of Wurzbürg, Germany.

2. p38 MAPK from bench to bedside and back again. Michael Marber, King's College, London, United Kingdom.

3. Inhibition of CaMKII and ROS in treating cardiomyocyte apoptosis and contractile dysfunction. Martín Vila Petroff, Centro de Investigaciones Cardiovasculares Dr. H.E. Cingolani, La Plata, Buenos Aires, Argentina.

4. MMP2 regulation of post ischemic cardiac function. Huangtian Yang, Shanghai Institute for Biological Sciences, Shanghai, China.

5. Oral Abstract: p300 mediated acetylation of SERCA2a diminishes its activity and contributes to cardiac dysfunction. Przemyslaw Gorski, Icahn School of Medicine at Mount Sinai, New York, USA.

SYMPOSIA FOR 2016 WORLD CONGRESS LISTED BY THEME12

MECHANISMS OF PROGRESSION OF HEART FAILURE (Symposium 24)Chair: Martin LeWinter, UVM Medical Center, Burlington, Vermont, USA.Co-chair: Carlos A. Valverde, Centro de Investigaciones Cardiovasculares Dr. H.E. Cingolani, La Plata, Buenos Aires, Argentina.

1. Small molecule inhibition of fibrotic signaling for heart failure. Burns Blaxall, Cincinnati Children's, Cincinnati, Ohio, USA.

2. Cardiomyopathy in the setting of muscle disease. Elizabeth McNally, Department of Medicine-Cardiology, Northwestern University Feinberg School of Medicine, Chicago,

Illinois, USA.

3. DPP4 inhibitors and diabetic cardiomyopathy. Toyoaki Murohara, Nagoya University, Nagoya, Japan.

4. Soluble epoxide hydrolase activation by S-nitrosation contributes to cardiac ischemia-reperfusion injury. Yi Zhu, Tianjin Medical University, Tianjin, China.

5. Oral abstract: Lack of essential myosin light chain phosphorylation impairs cardiac ability to adapt to augmented physical demand.

Selina Hein, Heidelberg University Hospital, Baden-Württemberg, Germany.

DIASTOLIC DYSFUNCTION - BASIC BIOLOGY AND CLINICAL IMPLICATIONS (Symposium 28)Chair: Rebecca Ritchie, Baker IDI Heart & Diabetes Inst, Melbourne, Australia.Co-chair: Nazha Hamdani, Institute of Physiology, Bochum, Germany.

1. Cellular and molecular regulation of cardiac fibrotic remodeling. Jennifer Davis, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

2. Cardiac isoform expression - a personalized and systems approach to diastolic heart failure. Michael Gotthardt, Max-Delbrük-Center for Molecular Medicine, Berlin, Germany.

3. Determinants of diastolic dysfunction in HFpEF. Martin LeWinter, UVM Medical Center, Burlington, Vermont, USA.

4. Role of cMyBP-C in diastolic dysfunction. Sabine J. van Dijk, Institute for Cardiovascular Research, Amsterdam, Netherlands.

5. Impact of cGMP-PKG pathway modulation on Titin phosphorylation and Titin- based myocardial passive stiffness. Nazha Hamdani, Institute of Physiology, Bochum, Germany.

Cardiac Metabolism

KAITO SYMPOSIUM: CARDIAC METABOLISM IN HEART FAILURE (Symposium 6)Chair: Lea Delbridge, University of Melbourne, Melbourne, Australia.Co-chair: Motoaki Sano, Keio University, Tokyo, Japan.

1. W hat can magnetic resonance spectroscopy tell us about cardiac energy metabolism in heart failure? Andrew Murray, Cambridge, United Kingdom.

2. Reciprocal signaling between cardiac sarcomeres and metabolism. John Solaro, University of Illinois, Illinois, USA.3. Lipid metabolism of the normal and failing human heart. Christian Schulze, Columbia University, New York, USA.

4. Mechanisms of protein aggregation in heart failure. Federica Del Monte, Harvard Medical School, Boston, Massachusetts, USA.

5. Oral Abstract: Metabolic remodeling of branched-chain amino acids promotes heart failure via mitochondrial suppression. Haipeng Sun, Shanghai, China.

NOVEL REGULATORY PATHWAYS OF CARDIAC METABOLISM (Symposium 17)Chair: E. Dale Abel, University of Iowa, Iowa, USA.Co-chair: Helena Viola, University of Western Australia, Crawley,Western Australia.

1. KLF5: An underappreciated transcriptional regulator of cardiac and systemic metabolism. Konstantinos Drosatos, Temple University, Philadelphia, Pennsylvania, USA.

2. Impact of dietary salt intake on cardiac remodeling. Jose Geraldo Mill, Federal University Espirito Santo, Vitoria, Brazil.

3. Adipokines and cardiovascular disease. Noriyuki Ouchi, Nagoya University Graduate School of Medicine, Nagoya, Japan.

4. Post-translational control of mitochondria and ER in cardiac and inflammatory disease. Michael Sack, Center for Molecular Medicine, Bethesda, Maryland, USA.

5. Oral Abstract: Lowering the miR-181c Expression Protects the Heart from Obesity. Samarjit Das, Johns Hopkins, Baltimore, Maryland, USA.

13ISHR XXII WORLD CONGRESS • APRIL 18-21, 2016Buenos Aires - Argentina

www.ishrbuenosaires2016.org.ar

Hola Charly, recién me escribió R. Moss diciendo que E. Douglas Lewandowski, speaker del simposio 6 se bajó y que lo va a reemplazar como speaker John Solaro, University of Illinois, Illinois, USA. con la charla titulada."Reciprocal Signaling Between Cardiac Sarcomeres and Metabolism"

Podrias fijarte de cambiar el program by theme y el by day sacando a Lewandowski y poniendo a Solaro. Tambien habria que sacar a Lewandowski de la lista de speakers y poner a solaro. Seria bueno si lo podes hacer y despues mandarselo a Ines para que se lo vuelva a madar a diego el de la impernta que quizas todavia estamos a tiempo de cambiar.

M.

John Solaro, University of Illinois, Illinois, USA.

CARDIAC ENERGETICS IN DIABETIC CARDIOMYOPATHY (Symposium 23)Chair: Andrew Murray, Cambridge, United Kingdom.Co-chair: Kimberly Mellor, Auckland Bioengineering Institute, Auckland, New Zealand.

1. Novel targets of insulin signaling in the heart - links to heart failure. E. Dale Abel, University of Iowa, Iowa, USA.

2. Glycophagy-a pathology of deranged cardiomyocyte glycogen handling in metabolic stress. Lea Delbridge, University of Melbourne, Melbourne, Australia.

3. Diastolic dysfunction in diabetes mellitus. Rebecca Ritchie, Baker IDI Heart & Diabetes Institute, Melbourne, Australia.

4. Metabolic syndrome and cardiovascular disease. Rui-Ping Xiao, Peking University, Beijing, China.

5. Oral Abstract: SIRT2 contributes to the development of heart failure through a NRF2 dependent pathway. Hossein Ardehali, Northwestern University, Chicago, Illinois, USA.

METABOLIC INFLEXIBILITY IN HEART FAILURE (Symposium 27)Chair: Joan Heller Brown, University of California -San Diego, California, USA.Co-chair: Randi Parks, NIH, Bethesda, Maryland, USA.

1. Metabolic and proteomic analysis of mitochondrial metabolism in heart failure. Daniel Kelly, Sanford Burnham Prebys Medical Discovery, Orlando, Florida, USA.

2. Targeting cardiac energy metabolism as a therapy to treat heart failure. Gary D. Lopaschuk, University of Alberta, Alberta, Canada.

3. Altered Dynamics of Protein and Amino Acid Metabolism in Failing Heart. Heinrich Taegtmeyer, UTHealth Medical School, Houston, Texas, USA.

4. Post-translational modification of mitochondrial function in heart failure. Rong Tian, University of Washington, Seattle, Washington, USA.

5. Oral Abstract: Mice lacking the mitochondrial calcium uniporter have alterations in F1F0-ATP synthase. Randi Parks, NIH, Bethesda, Maryland, USA.

Cardiac Regulation: Beyond the Genome

EPIGENETICS OF HEART FAILURE (Symposium 2)Chair: Thomas Thum, Hannover Medical School, Hannover, Germany.Co-chair: Willem de Lange, University of Wisconsin, Madison, Wisconsin, USA.

1. Interplay between histone modification marks and DNA methylation in controlling cardiac gene expression. Gianluigi Condorelli, Humanitas Research Hospital, Milan, Italy.

2. Reversible Protein Acetylation in Heart Failure: Mechanism and Target. Joseph A. Hill, UT Southwestern Medical Center, Dallas, Texas, USA.

3. Remodeling chromatin structure in cardiovascular disease. Thomas Vondriska, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, USA.

4. Oral Abstract: Functional evaluation of the inhibition of upregulated microRNAs in afterload-enhanced engineered heart tissue.

Mark Hirt, University of Hamburg-Eppendorf, Hamburg, Germany.

5. Oral Abstract: Cardio fibroblasts regulate cardiomyocyte SUMOylation and contractility via miR-146a. Jae Gyun Oh, Icahn School of Medicine at Mount Sinai, New York, USA.

MODULATION OF TRANSCRIPTION IN CARDIOVASCULAR DEVELOPMENT AND DISEASE (Symposium 13)Chair: Joseph Hill, UT Southwestern Medical Center, Dallas, Texas, USA.Co-chair: Francine Marques, Baker IDI Heart and Diabetes Institute, Melbourne, Australia.

1. LncRNAs regulating cardiac hypertrophy. Ching-Pin Chang, Indiana University, Indianapolis, Indiana, USA.

2. Long noncoding RNAs in cardiac homeostasis and regeneration. Thierry Pedrazzini, Lausanne, Switzerland.

3. LncRNAs as therapeutic targets in cardiac remodeling. Thomas Thum, Hannover Medical School, Hannover, Germany.

4. Novel mechanisms in transcriptome reprogramming in heart failure. Yibin Wang, University of California-Los Angeles, Los Angeles, California, USA.

5. Oral Abstract: Transcardiac gradient of cardio-micrornas in the failing heart. Francine Marques, Baker IDI Heart and Diabetes Institute, Melbourne, Australia.


INHERITED CARDIOMYOPATHIES: FROM MUTATION TO THERAPY (Symposium 25)Chair: Peter Ferdinandy, University of Szeged, Szeged, Hungary.Co-chair: Vanessa Lima, University of Sao Paulo, Sao Paulo, Brazil.

1. Enzyme replacement therapy for cardiomyopathy in Barth Syndrome. Michael T. Chin, University of Washington, Seattle, Washington, USA.

2. Gene therapy in heart failure. Roger J. Hajjar, Icahn School of Medicine at Mount Sinai, New York, USA .

3. Mechanisms of sarcomeric dysfunction in HCM. Jolanda van der Velden, VU University Medical Center, Amsterdam, Netherlands.

4. Therapies for inherited and acquired cardiomyopathies. Michael Regnier, University of Washington, Seattle, Washington, USA.

5. Oral Abstract: Alda-1 improves cardiac function in the heart failure mice carrying human aldehyde dehydrogenase 2 E487K variant.

Vanessa Lima, University of Sao Paulo, Sao Paulo, Brazil.

MECHANICAL FORCES AND CALCIUM MICRODOMAINS (Symposium 33)Chair: Xander Wehrens, Baylor College of Medicine, Houston, Texas, USA. Co-chair: Luis Gonano, Centro de Investigaciones Cardiovasculares Dr. H.E. Cingolani, La Plata, Buenos Aires, Argentina.

1. Measuring calcium microdomains in the intact heart. Ariel Escobar, University of California, Merced, California, USA.

2. Calcium transport in human atrial myocytes. Rosana Bassani, University of Campinas, São Paulo, Brazil.

3. Intracellular calcium regulation by cardiac stretch. Gustavo Pérez, Centro de Investigaciones Cardiovasculares Dr. H.E. Cingolani, La Plata, Buenos Aires, Argentina.

4. Calcium microdomains organized by junctophilins. Long Sheng Song, University of Iowa, Iowa City, Iowa, USA.

5. Oral Abstract: Runx1 deficiency improves cardiomyocyte function post-myocardial infarction. Charlotte McCarroll, University of Glasgow, Glasgow, United Kingdom.

Cardioprotection and Injury

THE MITOCHONDRIAL CALCIUM MICRODOMAIN IN CARDIAC PATHOLOGY (Symposium 5)Chair: Jeffery Molkentin, UC Department of Pediatrics, Cincinnati, Ohio, USA.Co-chair: Stephan Lange, UC San Diego, San Diego, California, USA.

1. Mitochondrial calcium exchange in heart failure - new genetic models. John Elrod, Temple University, Philadelphia, Pennsylvania, USA.

2. T he MCU in ischemia-reperfusion injury. Tish Murphy, NIH, Bethesda, Maryland, USA.

3. Mitochondrial Ca regulating flight or fight response. Jeffery Molkentin, UC Department of Pediatrics, Cincinnati, Ohio, USA.

4. Targeting mitochondria in cell death in heart disease. Richard Kitsis, Albert Einstein College of Medicine, Bronx, New York, USA.

5. Oral Abstract: Postconditioning with mitochondria-targeting hydrogen sulfide donor Ap39. Qutuba Karwi, School of Pharmacy and Pharmaceutical Sciences, Cardiff, United Kingdom.

NOVEL MITOCHONDRIAL TARGETS FOR TREATING CARDIOVASCULAR DISEASE (Symposium 14)Chair: Heinrich Taegtmeyer, UT Health Medical School, Houston, Texas, USA.Co-chair: Catherine A. Makarewich, University of Texas Southwestern Medical Center, Texas, USA.

1. Mitochondrial turnover and cardiac metabolic remodeling. Gerald Dorn, Washington University, St. Louis, Missouri, USA.

2. Mitochondrial fission and fusion proteins as target for cardioprotection. Derek Hausenloy, Duke-NUS, Singapore.

3. Keeping mitochondria in shape: a matter of life and death. Luca Scorrano, Venetian Institute of Molecular Medicine, Padova, Italy.

4. Mitochondrial K channels as novel targets in heart failure. Brian O'Rourke, Johns Hopkins University School of Medicine, Baltimore, Maryland,USA.

5. Oral Abstract: Sympathetic nervous response to ischemia-reperfusion injury in humans is reduced and delayed with remote limb ischemic preconditioning.

Colleen Thomas, La Trobe University, Victoria, Australia.



ROLE OF MITOCHONDRIA IN CELL DEATH (Symposium 19)Chair: Charles Steenbergen, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.Co-chair: Grzegorz Sawicki, University of Saskatchewan, Saskatoon, Canada.

1. Role of F-ATP synthase in formation of the mitochondrial permeability transition pore. Paolo Bernardi, University of Padova, Padova, Italy.

2. The mPTP and its regulatory kinases in cardioprotection. Tetsuji Miura, Sapporo Medical University, Sapporo, Japan.

3. Mitochondrial protein S-nitrosylation in cardioprotection. Charles Steenbergen, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.

4. Calcium and CaMKII in ischemia/reperfusion injury. Carlos A. Valverde, Centro de Investigaciones Cardiovasculares Dr. H.E. Cingolani, La Plata, Buenos Aires, Argentina.

5. Oral Abstract: Co-administration of subthreshold doses of inhibitors of MMP-2, MLCK and NOS activities protects heart from ischemia/reperfusion injury.

Grzegorz Sawicki, University of Saskatchewan, Saskatchewan, Canada.

REGULATION OF AUTOPHAGY AND CELL DEATH PATHWAYS IN HEALTH AND DISEASE (Symposium 29)Chair: Lorrie Kirshenbaum, University of Manitoba, Winnipeg, Canada.Co-chair: Hiroshi Akazawa, University of Tokyo,Tokyo, Japan.

1. Mitophagy and biogenesis: paradoxical response to ischemia. Roberta Gottlieb, Cedars-Sinai Heart Institute, Los Angeles, California, USA.

2. Importance of mitochondrial quality control in the myocardium. Asa Gustafsson, University of California-San Diego, California, USA.

3. Interplay between autophagy, apoptosis and necrosis pathways. Lorrie Kirshenbaum, University of Manitoba, Winnipeg, Canada.

4. Mitochondrial degradation and inflammation in failing hearts. Kinya Otsu, King's College, London, United Kingdom.

5. Oral Abstract: Abnormal trafficking of connexin 43 on microtubules participates to the development of LMNA-related dilated cardiomyopathy.

Coline Macquart, INSERM, Paris, France.

NOVEL MITOCHONDRIAL LOCALIZATION AND FUNCTION OF SIGNAL TRANSDUCERS (Symposium 30)Chair: Peipei Ping, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, USA.Co-chair: Eliana C. Martinez, University of Miami Miller School of Medicine, Miami, Florida, USA.

1. Novel mitochondrial localization and function of signal transducers. Rainer Schulz, Justus Liebig University, Giessen, Germany.

2. G proteins and mitochondrial function. Joan Heller Brown, University of California -San Diego, California, USA.

3. The dynamic mitochondrial proteome. Peipei Ping, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.

2+4. Mitochondria Ca and cAMP signaling. Tulio Pozzan, University of Padova, Padova, Italy.

5. Oral Abstract: Targeting of muscle A-Kinase anchoring protein β-RSK3-complexes preserves cardiac structure and function following myocardial infarction.

Eliana C. Martinez, University of Miami Miller School of Medicine, Miami, Florida, USA.

Ion Channels and Arrhythmias

MECHANISMS OF CALCIUM-INDUCED ARRHYTHMIAS (Symposium 3)Chair: Louisiana State University, New Orleans, Louisiana, USA.Co-chair: James Bell, University of Melbourne, Melbourne, Australia.

1. Ryanodine receptors in arrhythmia. Ana María Gomez, University of Paris, Châtenay-Malabry, France.

2. Calmodulin Mutants and CPVT. Derek Laver, University of Newcastle, New South Wales, Australia.

3. Role of RyR mediated calcium leak in disrupting cellular rhythms. Gaetano Santulli, Columbia University, New York, USA.

4. Regulation and dysregulation of cardiac RyR's. Héctor Valdivia, University of Michigan, Ann Arbor, Michigan, USA.

2+5. Oral Abstract: Cardiomyocyte high Ca operational levels linked with arrhythmogenic vulnerability in a rat model of hypertrophic heart failure with preserved ejection fraction.

James Bell, University of Melbourne, Victoria, Australia.


MACROMOLECULAR COMPLEXES, COMPARTMENTATION SIGNALING AND CARDIAC ARRHYTHMIA (Symposium 7)Chair: Héctor Valdivia, University of Michigan, Ann Arbor, Michigan, USA.Co-chair: Jérémy Fauconnier, INSERM, Montpellier, France.

1. Engineering approaches to study channel structure function and nanodomains. Henry Colecraft, Columbia University, New York, USA.

2. Scanning ion conductance microscopy to study microdomain-specific activation of cardiac ion channels. Julia Gorelik, Imperial College, London, United Kingdom.

2+3. Alterations in intracellular Ca handling as a basis for triggered arrhythmias. Burkert Pieske, Universitatsmedizin, Berlin, Germany.

4. Models of ion channel microdomains and signaling dynamics. James Weiss, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, USA.

5. Oral Abstract: Cyclophilin D inhibition alters sarcoplasmic reticulum –mitochondria calcium transfer and triggers ventricular arrhythmia.

Jérémy Fauconnier, INSERM, Montpellier, France.

CALCIUM REGULATION: FROM PHYSIOLOGY TO CARDIOMYOPATHY (Symposium 20)Chair: Alejandro Aiello, Centro de Investigaciones Cardiovasculares Dr. H.E. Cingolani, La Plata, Buenos Aires, Argentina.Co-chair: Frederik Flenner, UKE, Hamburg, Germany.

1. Regulation of diastolic calcium: basic mechanisms. David Eisner, University of Manchester, Manchester, United Kingdom.

2. Targeting the alpha-interacting domain of the L-type calcium channel in prevention of cardiomyopathy. Livia Hool, The University of Western Australia, Crawley, Australia.

3. Male-female differences in SR calcium regulation. Susan Howlett, Dalhousie University, Nova Scotia, Canada.

4. X-ROS Signaling in heart: Stretch and calcium. W. Jon Lederer, University of Maryland, Baltimore, Maryland, USA.

5. Occurrence of arrhythmias and electrophysiologic abnormalities in a mouse model of hypertrophic cardiomyopathy. Frederik Flenner, UKE, Hamburg, Germany.

NOVEL MECHANISMS AND THERAPEUTIC TARGETS FOR ARRHYTHMIAS (Symposium 32)Chair: Livia Hool, The University of Western Australia, Crawley, Australia.Co-chair: David Hassel, Heidelberg University Hospital, Heidelberg, Germany.

1. Functional and structural atrial remodeling in disease. Katharine Dibb, Institute of Cardiovascular Sciences, Manchester, United Kingdom.

2. Redox regulation of RyR2. Paulina Donoso, University of Chile, Santiago de Chile, Chile.

3. Phospholamban in arrhythmogenic cardiomyopathy: A new surprise. Litsa Kranias, University of Cincinnati – College of Medicine, Cincinnati, Ohio, USA.

4. T-tubule and ryanodine receptor microdomains in ischemic heart disease. Karin Sipido, Katholieke Universiteit – Leuven, Belgium.

5. Oral Abstract: miR-19b Deficiency Impairs Cardiac Repolarization in Zebrafish. Alexander Benz, University Hospital, Heidelberg, Germany.

Regenerative Medicine

CARDIAC DAMAGE AND REPAIR (Symposium 1)Chair: Cecilia Mundiña-W, Centro de Investigaciones Cardiovasculares Dr. H.E. Cingolani, La Plata, Buenos Aires, Argentina.Co-chair: Zully Pedrozo, University of Chile, Santiago de Chile, Chile.

1. Rescuing heart function by HIF1 Alpha-transfected stem cells. Alberto Crottogini, Favaloro University, Buenos Aires, Argentina.

2. Cardiac repair and angiogenesis. Jose Krieger, University of São Paulo, São Paulo, Brazil.

3. Molecular mechanisms of cardiac autophagy. Sergio Lavandero, Universidad de Chile, Santiago de Chile, Chile.

4. Gene therapy for cardiac repair. Roger Hajjar, Icahn School of Medicine at Mount Sinai, New York, USA.

5. Oral Abstract: Short telomeres induce autophagy and modulate cardiac progenitor Cell Fate. Nirmala Hariharan, University of California - Davis, California, USA.



SYMPOSIA FOR 2016 WORLD CONGRESS LISTED BY THEME

REGENERATION - POSTNATAL VERSUS ADULT REPAIR (Symposium 12)Chair: Tim Kamp, University of Wisconsin-Madison, Madison, Wisconsin, USA.Co-chair: Mohsin Kahn, Lewis Katz School of Medicine, Temple University, Philadelphia, USA.

1. miRNAs and proliferation in postnatal versus adult cardiomyocytes. Mauro Giacca, Int'l Centre for Genetic Engineering and Biotechnology, Trieste, Italy.

2. Cardiac regeneration and rejuvenation by endogenous stem cells. Patrick Hsieh, Institute for Biomedical Sciences, Taipei, Taiwan.

3. Molecular mechanisms of postnatal versus adult regeneration. Enzo Porrello, University of Queensland, Queensland, Australia.

4. Clinical application of iPS cells for the treatment of severe congestive heart failure. Keiichi Fukuda, Keio University School of Medicine, Tokyo, Japan.

5. Oral Abstract: Pluripotent stem cell microRNA-294 as a mediator of cardiac proliferative response in the heart after myocardial infarction.

Mohsin Kahn, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA.

SIGNALING IN MYOCARDIAL REGENERATION (Symposium 21)Chair: Steven Houser, Temple University, Philadelphia, Pennsylvania, USA.

1. Lineage Reprogramming Fibroblasts to Induced Cardiac Progenitor Cells. Timothy Kamp, University of Wisconsin-Madison, Madison, Wisconsin, USA.

2. Calcium handling of iPSC-derived cardiomyocytes - the good, the bad and the ugly. Bjorn Knollman, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

3. Adrenergic signaling in human induced pluripotent stem cell-derived cardiomyocytes. Sian Harding, Imperial College, London, United Kingdom.

4. Oral Abstract: Bone marrow mesenchymal stem cells reprogrammed into cardiac progenitor cells by nano-protein transfection bio-unit.

Xi-Yong Yu, Institute of Vascular Medicine, Beijing, China.

BAYER YAKUHIN SYMPOSIUM: MAKING CARDIAC REGENERATION HAPPEN - ROADBLOCKS TO OVERCOME (Symposium 22)Chair: Keiichi Fukuda, Keio University School of Medicine, Tokyo, JapanCo-chair: Megan Monsanto,San Diego State University, San Diego, California, USA.

1. Stem cell therapy and post-infarction remodeling. Jianyi 'Jay' Zhang, University of Minnesota, Minneapolis, Minnesota, USA.

2. Regulation of myocyte death and formation. Steven Houser, Temple University, Philadelphia, Pennsylvania, USA.

3. Converting fibroblasts into cardiomyocytes. Masaki Ieda, Keio University School of Medicine, Tokyo, Japan.

4. Ploidy: the genetic underpinning of regeneration. Mark Sussman, San Diego State University Heart Institute, San Diego, California, USA.

5. Oral Abstract: CardioClusters: Harnessing the power of multi-lineage cardiac stem cells. Megan Monsanto, San Diego State University, San Diego, California, USA.

Signaling in Disease and Therapy

CHAGAS, A NOT SO NEGLECTED TROPICAL DISEASE (Symposium 9) Chair: Elena Lascano, Universidad Favaloro, Buenos Aires, Argentina.Co-chair: Emiliano Medei, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

1. Functional and structural alterations of cardiac muscle mitochondria in Chagasic heart failure. Patricia Paglini-Oliva, National University of Córdoba, Córdoba, Argentina.

2. Mechanisms underlying enhanced vulnerability to ventricular arrhythmias in chronic Chagasic patients. Emiliano Medei, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

3. Protective impact of Galectin-1 on cardiac myocyte damage induced by Trypanosoma cruzi. Karina Gómez, Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Bs As, Argentina.

4. Nanomedicines for the treatment of Chagas disease. Eder Romero, Quilmes National University, Quilmes, Buenos Aires, Argentina.

5. Oral Abstract: Thyroid stimulating hormone can directly modulate cardiac electrical activity. Maria Ruocco, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

18

INTRACRINE SIGNALING IN THE HEART (Symposium 11)Chair: Laurence Brunton, University of Virginia, Charlottesville, Virginia, USA.Co-chair: Alessandra Ghigo, University of Torino, Torino, Italy.

1. Redox regulation of protein kinase G in the cardiovascular system. Philip Eaton, The Rayne Institute, London, United Kingdom.

2. Regulation of cardiac function by nuclear alpha-adrenergic receptors. Timothy O'Connell, University of Minnesota, Minneapolis, Minnesota, USA.

3. The many splendid but complex actions of opioid peptides in the heart: regulators of cell differentiation, metabolism, adaptation and survival.

Salvatore Pepe, Murdoch Childrens Research Institute, Melbourne, Australia.

4. New insights into adrenergic regulation of cardiac fibrosis. You Yi Zhang, Institute of Vascular Medicine, Beijing, China.

5. Oral Abstract: Inhibition of phosphoinositide 3-kinase γ promotes cardiac mitophagy and prevents anthracycline-related cardiomyopathy.

Alessandra Ghigo, University of Torino, Torino, Italy.

HYPERTENSION AND HYPERTROPHY (Symposium 15)Chairs: Irene Ennis, Centro de Investigaciones Cardiovasculares Dr. H.E. Cingolani, La Plata, Buenos Aires, Argentina.Co-chair: Verónica De Giusti, Centro de Investigaciones Cardiovasculares Dr. H.E. Cingolani, La Plata, Buenos Aires, Argentina.

1. The NHE-1 as a point of divergence in cardiac hypertrophy signaling. I rene Ennis, Centro de Investigaciones Cardiovasculares Dr. H.E. Cingolani, La Plata, Buenos Aires, Argentina.

2. The role of Cardiac Thyrotropin Releasing Hormone (cTRH) in heart fibrosis and hypertrophy. Silvia García, Instituto de Investigaciones Médicas “A. Lanari”, Buenos Aires, Argentina.

3. Let's keep running… exercise, basic science and the knowledge gaps. Julie McMullen, Baker IDI Heart and Diabetes Institute, Melbourne, Australia.

4. Protective axis of the renin-angiotensin system. Mariela Gironacci, Instituto de Química y Fisicoquímica Biológicas, Buenos Aires, Argentina.

5. Oral Abstract: Phosphorylation of cofilin-1 by ERK1/2 signaling alters cardiac actin dynamics and causes LMNA-related dilated cardiomyopathy.

Maria Chatzifrangkeskou, INSERM, Paris, France.

NEW MOLECULAR INSIGHTS OF GPCR SIGNALING IN THE HEART (Symposium 18)Chair: Hossein Ardehali, Northwestern University, Chicago, Illinois, USA.Co-chair: Simon Diering, University Medical Center - Hamburg, Hamburg, Germany.

1. GRK2 actions on signaling in the heart. Walter Koch, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.

2. Post-translational modification of large sarcomeric proteins in adrenergic regulation of cardiac function. Henk Granzier, University of Arizona, Arizona, USA.

3. New insights into β-arrestin-biased GPCR signaling. Howard Rockman, Duke University, Durham, North Carolina, USA.

4. Ubiquitination of βARs in β-arrestin mediated signaling. Sudha Shenoy, Duke University, Durham, North Carolina, USA

5. Oral Abstract: Oxidative activation of cAMP-dependent protein kinase by nitroxyl modulates myofilament protein phosphorylation.

Simon Diering, University Medical Center - Hamburg, Hamburg, Germany.

SIGNAL TERMINATION IN CARDIAC PHYSIOLOGY AND DISEASE (Symposium 26)Chair: Walter Koch, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.Co-chair: Sudhiranjan Gupta, Texas A&M, Temple, Texas, USA.

1. The flip side: neurohormonal regulation of cardiac phosphatases. Metin Avkiran, King's College London, London, United Kingdom.

2. Lysine deacetylation: opposing roles for HDAC isoforms in hypertrophy?. Timothy McKinsey, University of Colorado – Denver, Colorado, USA.

3. Disulfide bond reduction: the many faces of thioredoxin-1. Junichi Sadoshima, Rutgers New Jersey Medical School, Newark, New Jersey, USA.

4. Isoform-specific functions of phosphodiesterases. Manuela Zaccolo, University of Oxford, Oxford, United Kingdom.

5. Oral Abstract: Inhibition of MicroRNA-130a prevents Angiotensin II-induced cardiac remodeling and improved cardiac function. Sudhiranjan Gupta, Texas A&M, Temple, Texas, USA.



NEW INSIGHTS INTO THE ROLE OF CaMKII IN THE HEART (Symposium 31)Chair: Johannes Backs, University of Heidelberg, Heidelberg, Germany.Co-chair: Javier Duran, University of Chile, Santiago de Chile, Chile.

1. Redox regulation of CaMKII and mitochondrial function. Mark E. Anderson, John Hopkins University, Maryland, USA.

2. Pathways of CaMKII activation in the heart. Physiological and pathological consequences. Julieta Palomeque, Centro de Investigaciones Cardiovasculares Dr. H.E. Cingolani, La Plata, Buenos Aires, Argentina.

3. The tango between PKA and CaMKII signaling in cardiac pacemarker. Yael Yaniv, Israel Institute of Technology, Haifa, Israel.

4. Role of phospholamban ablation in CaMKII-induced arrhythmias and cardiac damage . Alicia Mattiazzi, Centro de Investigaciones Cardiovasculares Dr. H.E. Cingolani, La Plata, Buenos Aires, Argentina.

5. Oral Abstract: Testosterone activates MEF2 through CaMKII and androgen receptor to induce cardiomyocyte hypertrophy.

Javier Duran, University of Chile, Santiago de Chile, Chile.


TIME

7.30

8.00

8.30 -10.00

8.30

8.45

9.00

9.15

9.30

9.45

10.00

10.00

10.20-11.50

10.20

10.35

10.50

11.05

11.20

11.35

PROGRAM BY DAYMONDAY

th18april

ROOM & LOCATION

Registration deskGround floor

Foyer Aula Magna1º floor

Juan Pablo II2º floor

Foyer Juan Pablo II2º floorAuditorium 2Ground floor


ACTIVITY

ECI Registration opens.

Speaker ready room opens.

ECI Symposium 1.Chairs: Sarah Franklin, University of Utah, Salt Lake City, Utah, USA. Kimberley Mellor, Auckland Bioengineering Institute, Auckland, New Zealand.

TRPV2 REGULATES THE DEVELOPMENT OF MYOCYTE HYPERTROPHY.Rubistein, Jack. University of Cincinnati, Cincinnati, Ohio, USA.

NORMALIZATION OF CARDIAC ENERGY METABOLISM AND LEFT VENTRICULAR HYPERTROPHY PRECEDE FUNCTIONAL RECOVERY IN THE REGRESSION OF HEART FAILURE.Byrne Nikole J. University of Alberta, Edmonton, Canada.

HAX-1 REGULATES CONTRACTILE RECOVERY AFTER ISCHEMIA/REPERFUSION INJURY BY PREVENTING SERCA2A DEGRADATION.Bydwell Philip. University of Cincinnati, Cincinnati, Ohio, USA.

PROTEOSEQ – A PROTEOTRANSCRIPTOMICS APPROACH TO DECODE ALTERNATIVE ISOFORM EXPRESSION IN CARDIAC HYPERTROPHY.Lam, Maggie PY. University of California, Los Angeles, California, USA.

MONOAMINE OXIDASES ARE MAJOR CONTRIBUTORS TO MITOCHONDRIAL ROS FORMATION AND DYSFUNCTION, AND CARDIAC DAMAGE IN DIABETIC CARDIOMYOPATHY.Deshwal, Soni. University of Padova, Padova, Italy.

ADP-STIMULATED CONTRACTION: A PREDICTOR OF THIN-FILAMENT ACTIVATION IN CARDIAC DISEASE.Sequeira, Vasco. VU University Medical center, Amsterdam, The Netherlands.

Coffee break.

International Council Meeting I.

ECI Symposium 2.Chairs: Stephan Lange, University of California-San Diego, San Diego, California, USA. Carlos A. Valverde, Centro de Investigaciones Cardiovasculares Dr. H.E. Cingolani, La Plata, Buenos Aires, Argentina.

FOLIC ACID REDUCES DOXORUBICIN-INDUCED CARDIOMYOPATHY BY MODULATING ENDOTHELIAL NITRIC OXIDE SYNTHASE.Octavia, Yanti. Erasmus MC, Rotterdam, The Netherlands.

ENDOGENOUS ANNEXIN-A1 IS CARDIOPROTECTIVE AGAINST MYOCARDIAL INFARCTION IN MICE IN VIVO.Qin, Cheng Xue. Baker IDI Heart and Diabetes Institute, Melbourne, Australia.

IDENTIFICATION OF A HIGH AFFINITY, HIGH EFFICACY ADENOSINE A RECEPTOR AGONIST 2B

WITH POTENT ANTI-FIBROTIC ACTIVITY.Vecchio, Elizabeth. Monash University, St Kilda East, Australia.

PROLIFERATIVE AND HYPERTROPHIC DEFECTS CONTRIBUTES TO LMNA ASSOCIATED DILATED CARDIOMYOPATHY.Onoue, Kenji. Nara Medical University, Kashihara, Japan.

POLYCYSTIN-1 REGULATES L-TYPE CALCIUM CHANNEL STABILIZATION DURING MECHANICAL STRETCH IN CARDIOMYOCYTES.Pedrozo, Zully. Facultad de Medicina, Universidad de Chile, Santiago de Chile, Chile.

ENDOTHELIAL ATP-BINDING CASSETTE G1 IN MOUSE ENDOTHELIUM PROTECTS AGAINST HEMODYNAMIC-INDUCED ATHEROSCLEROSIS.He, Jinlong. Tianjin Medical University, Tianjin, China.

21

PROGRAM BY DAYMONDAY

th18april

11.50

12.00

12.10-13.00

13.00

14.30

15.00

16.00

16.00

16.25

16.50

17.15

17.40

16.00

16.00

16.25

16.50

17.15

Foyer Juan Pablo II2º floorRegistration deskGround floor

Aula Magna1º floor

Foyer Juan Pablo II2º floor


AuditoriumGround floor

Microcine Ground floor

Coffee break.

World Congress registration opens.

Workshop Panel: “Publishing: A Career Development Panel”Chair: Helena Viola, University of Western Australia, Perth, Australia. Co-chair: Sakthivel Sadayappan, Loyola University, Chicago, Illinois, USA.

David Eisner (Editor in Chief of JMCC).Joseph Hill (incoming Editor in Chief of Circulation).Howard Rockman (Editor in Chief of JCI).Karin Sipido (Editor in Chief of Cardiovascular Research).Rui-Ping Xiao (Associate Editor of the New England Journal of Medicine).

Lunch & networking with ECI and the ISHR International council.

Opening Ceremony.

Keith Reimer Distinguished Lecture:Chair: David Eisner, University of Manchester, Manchester, United Kingdom. Rodolphe Fischmeister, INSERM, Châtenay-Malabry Cedex, France.“Cyclic nucleotide microdomains and phosphodiesterases: Small sinks with smart drains can do a lot!”.

Symp. 1: Cardiac damage and repair Chair: Cecilia Mundiña-Weilenmann, Centro de Investigaciones Cardiovasculares Dr. H.E. Cingolani, La Plata, Buenos Aires, Argentina.Co-chair: Zully Pedrozo, University of Chile, Santiago de Chile, Chile.

1. RESCUING HEART FUNCTION BY HIF1 ALPHA-TRANSFECTED STEM CELLS.Alberto Crottogini, Favaloro University, Buenos Aires, Argentina.

2. CARDIAC REPAIR AND ANGIOGENESIS.Jose Krieger, University of São Paulo, São Paulo, Brazil.

3. MOLECULAR MECHANISMS OF CARDIAC AUTOPHAGY.Sergio Lavandero, Universidad de Chile, Santiago de Chile, Chile.

4. GENE THERAPY FOR CARDIAC REPAIR.Roger Hajjar, Icahn School of Medicine at Mount Sinai, New York, USA.

5. ORAL ABSTRACT: SHORT TELOMERES INDUCE AUTOPHAGY AND MODULATE CARDIAC PROGENITOR CELL FATE.Nirmala Hariharan, University of California - Davis, Davis, California, USA.

Symp. 2: Epigenetics of heart failureChair: Thomas Thum, Hannover Medical School, Hannover, Germany.Co-chair: Willem de Lange, University of Wisconsin, Madison, Wisconsin, USA.

1. INTERPLAY BETWEEN HISTONE MODIFICATION MARKS AND DNA METHYLATION IN CONTROLLING CARDIAC GENE EXPRESSION.Gianluigi Condorelli, Humanitas Research Hospital, Milan, Italy.

2. REVERSIBLE PROTEIN ACETYLATION IN HEART FAILURE: MECHANISM AND TARGET.Joseph A. Hill, UT Southwestern Medical Center, Dallas, Texas, USA.

3. REMODELING CHROMATIN STRUCTURE IN CARDIOVASCULAR DISEASE.Thomas Vondriska, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.

4. ORAL ABSTRACT: FUNCTIONAL EVALUATION OF THE INHIBITION OF UPREGULATED microRNAs IN AFTERLOAD-ENHANCED ENGINEERED HEART TISSUE.Mark Hirt, University of Hamburg-Eppendorf, Germany.

ACTIVITYTIME ROOM & LOCATION

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5. ORAL ABSTRACT: CARDIO FIBROBLASTS REGULATE CARDIOMYOCYTE SUMOYLATION AND CONTRACTILITY VIA miR-146a.Jae Gyun Oh, Icahn School of Medicine at Mount Sinai, Manhattan, New York, USA.

Symp. 3: Mechanisms of calcium leak-induced arrhythmias.Chairs: David Lefer, Louisiana State University, Louisiana, USA.Co-chair: James Bell, University of Melbourne, Melbourne, Australia.

1. RYANODINE RECEPTORS IN ARRHYTHMIA.Ana María Gómez, University of Paris, Châtenay-Malabry, France.

2. CALMODULIN MUTANTS AND CPVT.Derek Laver, University of Newcastle, New South Wales, Australia.

3. ROLE OF RYR MEDIATED CALCIUM LEAK IN DISRUPTING CELLULAR RHYTHMS.Gaetano Santulli, Columbia University, New York, USA.

4. REGULATION AND DYSREGULATION OF CARDIAC RYR'S.Héctor Valdivia, University of Michigan, Ann Arbor, Michigan, USA.

2+5. ORAL ABSTRACT: CARDIOMYOCYTE HIGH CA OPERATIONAL LEVELS LINKED WITH ARRHYTHMOGENIC VULNERABILITY IN A RAT MODEL OF HYPERTROPHIC HEART FAILURE WITH PRESERVED EJECTION FRACTION.James Bell, University of Melbourne, Melbourne, Australia.

Symp. 4: CANON SYMPOSIUM: Cardiac hypertrophy and failure. Chair: Matt Hori, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan.Co-chair: Delaine Ceholski, Icahn School of Medicine at Mount Sinai, Manhattan, New York, USA. 1. CARDIAC DNA DAMAGE CAUSES HEART FAILURE.Issei Komuro, The University of Tokyo, Tokyo, Japan.

2. DEVELOPMENT OF GENE DELIVERY TOOLS TARGETING PI3K-REGULATED MRNAS AND MICRORNAS TO IMPROVE FUNCTION OF THE FAILING HEART.Julie McMullen, Baker IDI Heart and Diabetes Institute, Melbourne, Australia.

3. NATRIURETIC PEPTIDE SYSTEM: ITS ROLE IN HEART FAILURE, AND ACUTE MYOCARDIAL INFARCTION.Yoshihiko Saito, Nara Medical University, Nara, Japan.

4. EXERCISE TRAINING IN HEART FAILURE. Patricia Brum, University of Sao Paolo, Sao Paolo, Brazil .

5. ORAL ABSTRACT: MODELLING DILATED CARDIOMYOPATHY-LINKED MUTATIONS IN PHOSPHOLAMBAN USING GENE EDITING IN IPS-DERIVED CARDIOMYOCYTES.Delaine Ceholski, Icahn School of Medicine at Mount Sinai, Manhattan, New York, USA.

Outstanding Investigator Award: Chair: Metin Avkiran, King´s College London, London, United Kingdom.Johannes Backs, University of Heidelberg, Heidelberg, Germany. “Cardiac Epigenetics - From mechanisms to translation”.

Aula Magna1º floor

Room 2042º floor


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Registration

Symp. 5: The mitochondrial calcium domain in cardiac pathologyChair: Jeffery Molkentin, UC Department of Pediatrics, Cincinnati, Ohio, USA.Co-chair: Stephan Lange, UC- San Diego, San Diego, California, USA.

1. MITOCHONDRIAL CALCIUM EXCHANGE IN HEART FAILURE - NEW GENETIC MODELS.John Elrod, Temple, University, Philadelphia, Pennsylvania, USA.

2. THE MCU IN ISCHEMIA-REPERFUSION INJURY.Tish Murphy, NIH, Bethesda, Marylan, USA.

3. MITOCHONDRIAL CA REGULATING FLIGHT OR FIGHT RESPONSE.Jeffery Molkentin, UC Department of Pediatrics, Cincinnati, Ohio, USA.

4. TARGETING MITOCHONDRIA IN CELL DEATH IN HEART DISEASE.Richard Kitsis, Albert Einstein College of Medicine, Bronx, New York, USA.

5. ORAL ABSTRACT: POSTCONDITIONING WITH MITOCHONDRIA-TARGETING HYDROGEN SULFIDE DONOR AP39.Qutuba Karwi, School of Pharmacy and Pharmaceutical Sciences, Cardiff, United Kingdom.

Symp. 6: KAITO SYMPOSIUM: Cardiac metabolism in heart failure Chair: Lea Delbridge, University of Melbourne, Melbourne, Australia.Co-chair: Motoaki Sano, Keio University, Japan.

1. WHAT CAN MAGNETIC RESONANCE SPECTROSCOPY TELL US ABOUT CARDIAC ENERGY METABOLISM IN HEART FAILURE?.Andrew Murray, Cambridge, United Kingdom.

2. RECIPROCAL SIGNALING BETWEEN CARDIAC SARCOMERES AND METABOLISM.John Solaro, University of Illinois, Illinois, USA.

3. LIPID METABOLISM OF THE NORMAL AND FAILING HUMAN HEART.Christian Schulze, Columbia University, New York, USA.

4. MECHANISMS OF PROTEIN AGGREGATION IN HEART FAILURE.Federica Del Monte, Beth Israel Deaconess Medical Centre-Harvard, Boston, Massachusetts, USA.

5. ORAL ABSTRACT: METABOLIC REMODELING OF BRANCHED-CHAIN AMINO ACIDS PROMOTES HEART FAILURE VIA MITOCHONDRIAL SUPPRESSION.Haipeng Sun, Shanghai, China.

Symp. 7: Macromolecular complexes, compartmentation signaling and cardiac arrhythmia. Chair: Héctor Valdivia, University of Michigan, Ann Arbor, Michigan, USA.Co-chair: Jérémy Fauconnier, INSERM, Montpellier, France.

1. ENGINEERING APPROACHES TO STUDY CHANNEL STRUCTURE FUNCTION AND NANODOMAINS.Henry Colecraft, Columbia University, New York, USA.

2. SCANNING ION CONDUCTANCE MICROSCOPY TO STUDY MICRODOMAIN-SPECIFIC ACTIVATION OF CARDIAC ION CHANNELS.Julia Gorelik, Imperial College London, London, United Kingdom.

2+3. ALTERATIONS IN INTRACELLULAR Ca HANDLING AS A BASIS FOR TRIGGERED ARRHYTHMIAS.Burkert Pieske, Medical University of Graz, Graz, Austria.

4. MODELS OF ION CHANNEL MICRODOMAINS AND SIGNALING DYNAMICS.James Weiss, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, USA.

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Aula Magna1º floor

Room 2042º floor

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Juan Pablo IIB (2º floor) and Reading Room (1º floor)


ACTIVITY

5. ORAL ABSTRACT: CYCLOPHILIN D INHIBITION ALTERS SARCOPLASMIC RETICULUM -MITOCHONDRIA CALCIUM TRANSFER AND TRIGGERS VENTRICULAR ARRHYTHMIA.Jérémy Fauconnier, INSERM, Montpellier, France.

Symp. 8: Novel mechanisms in cardiomyopathyChair: Richard L. Moss, University of Wisconsin – Madison, USA.Co-chair: Sakthivel Sadayappan, Loyola University - Chicago. Illinois, USA.

1. AUTOPHAGY-LYSOSOMAL PATHWAY IN INHERITED SARCOMERIC CARDIO MYOPATHIES.Lucie Carrier, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

2.PROTEOTOXICITY: A COMMON PATHWAY IN CARDIAC AND NEURODEGENERATIVE DISEASE.Jeffrey Robbins, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.

3. PROTEOTOXIC SIGNALING PATHWAYS.Marco Sandri, Venetian Institute of Molecular Medicine, Padova, Italy.

4. HYPERTROPHIC CARDIOMYOPATHY MUTATIONS EXPRESSED IN IPSCS.J. Carter Ralphe, University of Wisconsin-Madison, Madison, Wisconsin, USA.

5. ORAL ABSTRACT: A PATHOGENIC MYBPC3 25-BP POLYMORPHIC VARIANT CAUSES HYPERTROPHIC CARDIOMYOPATHY IN SOUTH ASIAN DESCENDANTS.Sakthivel Sadayappan, Loyola University - Chicago. Illinois, USA.

Symp. 9: Chagas, a not so neglected tropical diseaseChair: Elena Lascano, Universidad Favaloro, Buenos Aires, Argentina.Co-chair: Emiliano Medei, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

1. FUNCTIONAL AND STRUCTURAL ALTERATIONS OF CARDIAC MUSCLE MITOCHONDRIA IN CHAGASIC HEART FAILURE.Patricia Paglini-Oliva, National University of Córdoba, Córdoba, Argentina.

2. MECHANISMS UNDERLYING ENHANCED VULNERABILITY TO VENTRICULAR ARRHYTHMIAS IN CHRONIC CHAGASIC PATIENTS.Emiliano Medei, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

3. PROTECTIVE IMPACT OF GALECTIN-1 ON CARDIAC MYOCYTE DAMAGE INDUCED BY TRYPANOSOMA CRUZI.Karina Gómez, Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Buenos Aires, Argentina.

4. NANOMEDICINES FOR THE TREATMENT OF CHAGAS DISEASE.Eder Romero, Quilmes National University, Quilmes, Argentina.

5. ORAL ABSTRACT: THYROID STIMULATING HORMONE CAN DIRECTLY MODULATE CARDIAC ELECTRICAL ACTIVITY.Maria Ruocco, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Coffee break.

Research Achievement Award:Chair: Asa Gustafsson, University of California-San Diego, California, USA. Heping “Peace” Cheng, Peking University, Peking, China. “Protons trigger mitochondrial flashes for ATP homeostasis in the heart”.

Poster sessions & Lunch.

Richard J Bing Young Investigator Award: Finalist competition.Chair: David Eisner, University of Manchester, United Kingdom.




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PROGRAM BY DAY

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Aula Magna1º floor

Symp. 10: Oxidative stress in heart failureChair: Derek Laver, University of Newcastle, New South Wales, Australia.Co-chair: Sarah Franklin, University of Utah, Salt Lake City, Utah, USA.

1. NADPH OXIDASE ISOFORMS IN CARDIAC STRESS AND FAILURE.Ajay Shah, BHF Chair of Cardiology, King’s College Hospital, London, United Kingdom.

2. NITRIC OXIDE AND OXIDATIVE STRESS IN HEART FAILURE.David Lefer, Louisiana State University, New Orleans, Louisiana, USA.

3. BIOENERGETIC CONTROL OF HEART FUNCTION.Pierre Domingues Dos Santos, Universite de Bordeaux, Bordeaux, France.

4. SOURCES AND TARGETS OF MITOCHONDRIAL ROS IN HEART FAILURE.Fabio Di Lisa, University of Padova, Italy.

5. ROLE OF miRNA-33a IN DILATED CARDIOMYOPATHY.Anupam Mittal, Jawaharlal Nehru University, New Delhi, India.

Symp. 11: Intracrine signaling in the heart Chair: Laurence Brunton, University of Virginia, Charlottesville, Virginia, USA.Co-chair: Alessandra Ghigo, University of Torino, Torino, Italy.

1. REDOX REGULATION OF PROTEIN KINASE G IN THE CARDIOVASCULAR SYSTEM.Philip Eaton, The Rayne Institute, London, United Kingdom.

2. REGULATION OF CARDIAC FUNCTION BY NUCLEAR ALPHA-ADRENERGIC RECEPTORS.Timothy O’Connell, University of Minnesota, Minneapolis, Minnesota, USA.

3. THE MANY SPLENDID BUT COMPLEX ACTIONS OF OPIOID PEPTIDES IN THE HEART: REGULATORS OF CELL DIFFERENTIATION, METABOLISM, ADAPTATION AND SURVIVAL.Salvatore Pepe, Murdoch Childrens Research Institute, Melbourne, Australia.

4. NEW INSIGHTS INTO ADRENERGIC REGULATION OF CARDIAC FIBROSIS.You Yi Zhang, Institute of Vascular Medicine, Beijing, China.

5. ORAL ABSTRACT: INHIBITION OF PHOSPHOINOSITIDE 3-KINASE PROMOTES CARDIAC MITOPHAGY AND PREVENTS ANTHRACYCLINE-RELATED CARDIOMYOPATHY.Alessandra Ghigo, University of Torino, Torino, Italy.

Symp. 12: Regeneration-postnatal versus adult repairChair: Tim Kamp, Unviersity of Wisconsin-Madison, Madison, Winconsin, USA.Co-chair: Mohsin Kahn, Lewis Katz School of Medicine, Temple University, Philadelphia, USA.

1. miRNAs AND PROLIFERATION IN POSTNATAL VERSUS ADULT CARDIOMYOCYTES.Mauro Giacca, International Center for Genetic Engineering and Biotechnology, Trieste, Italy.

2. CARDIAC REGENERATION AND REJUVENATION BY ENDOGENOUS STEM CELLS.Patrick Hsieh, Institute for Biomedical Sciences, Taipei, Taiwan.

3. MOLECULAR MECHANISMS OF POSTNATAL VERSUS ADULT REGENERATION.Enzo Porrello, University of Queensland, Queensland, Australia.

4. CLINICAL APPLICATION OF IPS CELLS FOR THE TREATMENT OF SEVERE CONGESTIVE HEART FAILURE.Keiichi Fukuda, Keio University School of Medicine, Tokyo, Japan.

5. ORAL ABSTRACT: PLURIPOTENT STEM CELL MICRORNA-294 AS A MEDIATOR OF CARDIAC PROLIFERATIVE RESPONSE IN THE HEART AFTER MYOCARDIAL INFARCTION.Mohsin Kahn, Lewis Katz School of Medicine, Temple University, Philadelphia, USA.

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Room 2042º floor

Foyer Juan Pablo II2º floorAuditoriumGround floor


ACTIVITY

Symp. 13: Modulation of transcription in cardiovascular development and disease.Chair: Joseph Hill, UT Southwestern Medical Center, Dallas, Texas, USA.Co-chair: Francine Marques, Baker IDI Heart and Diabetes Institute, Melbourne, Australia. 1. LncRNAs REGULATING CARDIAC HYPERTROPHY.Ching-Pin Chang, Indiana University, Indianapolis, USA.

2. LONG NONCODING RNAs IN CARDIAC HOMEOSTASIS AND REGENERATION.Thierry Pedrazzini, Lausanne, Switzerland.

3. LncRNAs AS THERAPEUTIC TARGETS IN CARDIAC REMODELING.Thomas Thum, Hannover Medical School, Hannover, Germany.

4. NOVEL MECHANISMS IN TRANSCRIPTOME REPROGRAMMING IN HEART FAILURE.Yibin Wang, UCLA, Los Angeles, California, USA.

5. ORAL ABSTRACT: TRANSCARDIAC GRADIENT OF CARDIO-MICRORNAS IN THE FAILING HEART. Francine Marques, Baker IDI Heart and Diabetes Institute, Melbourne, Australia.

Coffee break.

Symp. 14: Novel mitochondrial targets for treating cardiovascular disease.Chair: Heinrich Taegtmeyer, UTHealth Medical School, Houston, Texas, USA.Co-chair: Catherine A. Makarewich, University of Texas Southwestern Medical Center, Texas, USA.

1. MITOCHONDRIAL TURNOVER AND CARDIAC METABOLIC REMODELING.Gerald Dorn, Washington University, St. Louis, Missouri, USA.

2.MITOCHONDRIAL FISSION AND FUSION PROTEINS AS TARGET FOR CARDIOPROTECTION.Derek Hausenloy, Duke-NUS, Singapore.

3. KEEPING MITOCHONDRIA IN SHAPE: A MATTER OF LIFE AND DEATH.Luca Scorrano, Venetian Institute of Molecular Medicine, Padua, Italy.

4. MITOCHONDRIAL K CHANNELS AS NOVEL TARGETS IN HEART FAILURE.Brian O’Rourke, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

5. ORAL ABSTRACT: SYMPATHETIC NERVOUS RESPONSE TO ISCHEMIA-REPERFUSION INJURY IN HUMANS IS REDUCED AND DELAYED WITH REMOTE LIMB ISCHEMIC PRECONDITIONING.Colleen Thomas, La Trobe University, Victoria, Australia.

Symp. 15: Hypertension and hypertrophy.Chair: Irene L. Ennis, Centro de Investigaciones Cardiovasculares Dr. H.E. Cingolani, La Plata, Buenos Aires, Argentina.Co-chair: Verónica C. De Giusti, Centro de Investigaciones Cardiovasculares Dr. H.E. Cingolani, La Plata, Buenos Aires, Argentina.

1. THE NHE-1 AS A POINT OF DIVERGENCE IN CARDIAC HYPERTROPHY SIGNALING.Irene Ennis, Centro de Investigaciones Cardiovasculares Dr. H.E. Cingolani, La Plata, Buenos Aires, Argentina.

2. THE ROLE OF CARDIAC THYROTROPIN RELEASING HORMONE (cTRH) IN HEART FIBROSIS AND HYPERTROPHY.Silvia García, Instituto de Investigaciones Médicas “A. Lanari”, Buenos Aires, Argentina.

3. LET'S KEEP RUNNING… EXERCISE, BASIC SCIENCE AND THE KNOWLEDGE GAPS.Julie McMullen, Baker IDI Heart and Diabetes Institute, Melbourne, Australia.

4. PROTECTIVE AXIS OF THE RENIN-ANGIOTENSIN SYSTEM.Mariela Gironacci, Instituto de Química y Fisicoquímica Biológicas, Buenos Aires,




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PROGRAM BY DAY

5. ORAL ABSTRACT: PHOSPHORYLATION OF COFILIN-1 BY ERK1/2 SIGNALING ALTERS CARDIAC ACTIN DYNAMICS AND CAUSES LMNA-RELATED DILATED CARDIOMYOPATHY.Maria Chatzifrangkeskou, INSERM, Paris, France.

Symp. 16: Inhibiting nodal signaling pathways as novel approaches to treating heart failure.Chair: John Solaro, University of Illinois, Illinois, USA.Co-chair: Przemyslaw Gorski, Icahn School of Medicine at Mount Sinai, Manhattan, New York, USA.

1.TARGETING ERK SIGNALING: A DOUBLE-EDGED SWORD?.Kristina Lorenz, University of Wurzbürg, Wurzbürg, Germany.

2. p38 MAPK FROM BENCH TO BEDSIDE AND BACK AGAIN.Michael Marber, King’s College, London, United Kingdom.

3. INHIBITION OF CaMKII AND ROS IN TREATING CARDIOMYOCYTE APOPTOSIS AND CONTRACTILE DYSFUNCTION.Martín Vila Petroff, Centro de Investigaciones Cardiovasculares Dr. H.E. Cingolani, La Plata, Buenos Aires, Argentina.

4. MMP2 REGULATION OF POST ISCHEMIC CARDIAC FUNCTION.Huangtian Yang, Shanghai Institute for Biological Sciences, Shanghai, China.

5. ORAL ABSTRACT: p300 MEDIATED ACETYLATION OF SERCA2a DIMINISHES ITS ACTIVITY AND CONTRIBUTES TO CARDIAC DYSFUNCTION.Przemyslaw Gorski, Icahn School of Medicine at Mount Sinai, Manhattan, New York, USA.

Symp. 17: Novel regulatory pathways of cardiac metabolism.Chair: E. Dale Abel, University of Iowa, Iowa, USA.Co-chair: Helena Viola, University of Western Australia, Crawley, Western Australia.

1. KLF5: AN UNDERAPPRECIATED TRANSCRIPTIONAL REGULATOR OF CARDIAC AND SYSTEMIC METABOLISM.Konstantinos Drosatos, Temple University, Philadelphia, Pennsylvania, USA.

2. IMPACT OF DIETARY SALT INTAKE ON CARDIAC REMODELING.Jose Geraldo Mill, Federal University Espirito Santo, Vitoria, Brazil.

3. ADIPOKINES AND CARDIOVASCULAR DISEASE.Noriyuki Ouchi, Nagoya University Graduate School of Medicine, Nagoya, Japan.

4. POST-TRANSLATIONAL CONTROL OF MITOCHONDRIA AND ER IN CARDIAC AND INFLAMMATORY DISEASE.Michael Sack, Center for Molecular Medicine, Bethesda, Maryland, USA.

5. ORAL ABSTRACT: LOWERING THE MIR-181C EXPRESSION PROTECTS THE HEART FROM OBESITY.Samarjit Das, Johns Hopkins, Baltimore, Maryland, USA.

Early Career Investigators- Social Meeting.

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Foyer Juan Pablo II2º floorMicrocine Ground floor

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Registration.

Speaker ready room.

Symp. 18: New molecular insights of GPCR signaling in the heart. Chair: Hossein Ardehali, Northwestern University, Chicago, Illinois, USACo-chair: Simon Diering, University Medical Center - Hamburg, Hamburg, Germany.

1. GRK2 ACTIONS ON SIGNALING IN THE HEART.Walter Koch, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.

2. POST-TRANSLATIONAL MODIFICATION OF LARGE SARCOMERIC PROTEINS IN ADRENERGIC REGULATION OF CARDIAC FUNCTION.Henk Granzier, University of Arizona, Arizona, USA.

3. NEW INSIGHTS INTO β-ARRESTIN-BIASED GPCR SIGNALING.Howard Rockman, Duke University, Durham, North Carolina, USA.

4. UBIQUITINATION OF βARs IN β-ARRESTIN MEDIATED SIGNALING.Sudha Shenoy, Duke University, Durham, North Carolina, USA.

5. ORAL ABSTRACT: OXIDATIVE ACTIVATION OF cAMP-DEPENDENT PROTEIN KINASE BY NITROXYL MODULATES MYOFILAMENT PROTEIN PHOSPHORYLATION.Simon Diering, University Medical Center - Hamburg, Hamburg, Germany.

Coffee break.

Symp. 19: Role of mitochondria in cell death.Chair: Charles Steenbergen, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.Co-chair: Grzegorz Sawicki, University of Saskatchewan, Saskatoon, Canada.

1. ROLE OF F-ATP SYNTHASE IN FORMATION OF THE MITOCHONDRIAL PERMEABILITY TRANSITION PORE.Paolo Bernardi, University of Padova, Padova, Italy.

2. THE mPTP AND ITS REGULATORY KINASES IN CARDIOPROTECTION.Tetsuji Miura, Sapporo Medical University, Sapporo, Japan.

3. MITOCHONDRIAL PROTEIN S-NITROSYLATION IN CARDIOPROTECTION.Charles Steenbergen, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.

4. CALCIUM AND CaMKII IN ISCHEMIA/REPERFUSION INJURY.Carlos A. Valverde, Centro de Investigaciones Cardiovasculares Dr. H.E. Cingolani, La Plata, Buenos Aires, Argentina.

5. ORAL ABSTRACT: CO-ADMINISTRATION OF SUBTHRESHOLD DOSES OF INHIBITORS OF MMP-2, MLCK AND NOS ACTIVITIES PROTECTS HEART FROM ISCHEMIA/REPERFUSION INJURY.Grzegorz Sawicki, University of Saskatchewan, Saskatoon, Canada.

Symp. 20: Calcium regulation: from physiology to cardiomyopathy.Chair: Alejandro Aiello, Centro de Investigaciones Cardiovasculares Dr. H.E. Cingolani, La Plata, Buenos Aires, Argentina.Co-chair: Frederik Flenner, UKE, Hamburg, Germany.

1. REGULATION OF DIASTOLIC CALCIUM: BASIC MECHANISMS.David Eisner, University of Manchester, Manchester, United Kingdom.

2. TARGETING THE ALPHA-INTERACTING DOMAIN OF THE L-TYPE CALCIUM CHANNEL IN PREVENTION OF CARDIOMYOPATHY.Livia Hool, The University of Western Australia, Crawley, Australia.

3. MALE-FEMALE DIFFERENCES IN SR CALCIUM REGULATION.Susan Howlett, Dalhousie University, Nova Scotia, Canada.

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Juan Pablo IIB (2º floor) and Reading Room (1º floor)AuditoriumGround floor


4. X-ROS SIGNALING IN HEART: STRETCH AND CALCIUM.W. Jon Lederer, University of Maryland, Baltimore, Maryland, USA.

5. OCCURRENCE OF ARRHYTHMIAS AND ELECTROPHYSIOLOGIC ABNORMALITIES IN A MOUSE MODEL OF HYPERTROPHIC CARDIOMYOPATHY.Frederik Flenner, UKE, Hamburg, Germany.

Symp.21: Signaling in myocardial regeneration.Chair: Steve Houser, Temple University, Philadelphia, Pennsylvania, USA.

1. LINEAGE REPROGRAMMING FIBROBLASTS TO INDUCED CARDIAC PROGENITOR CELLS.Timothy Kamp, University of Wisconsin-Madison, Madison, Wisconsin, USA.

2. CALCIUM HANDLING OF iPSC-DERIVED CARDIOMYOCYTES-THE GOOD, THE BAD AND THE UGLY.

Bjorn Knollman, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

3. ADRENERGIC SIGNALING IN HUMAN INDUCED PLURIPOTENT STEM CELL-DERIVED CARDIOMYOCYTES.Sian Harding, Imperial College London, London, United Kingdom.

4. ORAL ABSTRACT: BONE MARROW MESENCHYMAL STEM CELLS REPROGRAMMED INTO CARDIAC PROGENITOR CELLS BY NANO-PROTEIN TRANSFECTION BIO-UNIT.Xi-Yong Yu, Guangzhao Med Univ, China.

Nobel Laureate Lecture: Chair: Howard Rockman, Duke University, Durham, North Carolina, USA. Co-chair: Tish Murphy, NIH, Bethesda, Maryland, USA.Robert J Lefkowitz, Duke University, Durham, North Carolina, USA. “Seven Transmembrane Receptors”.

2016 ISHR General assemblyDistinguished Leader Award: Chair: Lea Delbridge, University of Melbourne, Melbourne, Australia.Salvatore Pepe, Murdoch Childrens Research Institute, Melbourne, Australia.

Posters Session & Lunch.

Symp. 22: BAYER YAKUHIN SYMPOSIUM: Making cardiac regeneration happen - roadblocks to overcome. Chair: Keiichi Fukuda, Keio University School of Medicine, Tokyo, Japan.Co-chair: Megan Monsanto, San Diego State University, San Diego, California, USA.

1. STEM CELL THERAPY AND POST-INFARCTION REMODELING.

Jianyi ‘Jay’ Zhang, University of Minnesota, Minneapolis, Minnesota, USA.2. REGULATION OF MYOCYTE DEATH AND FORMATION.

Steven Houser, Temple University, Philadelphia, Pennsylvania, USA.3. CONVERTING FIBROBLASTS INTO CARDIOMYOCYTES.

Ieda Masaki, Keio University School of Medicine, Tokyo, Japan.4. PLOIDY: THE GENETIC UNDERPINNING OF REGENERATION.

Mark Sussman, San Diego State University Heart Institute, San Diego, California, USA.5. ORAL ABSTRACT: CARDIOCLUSTERS: HARNESSING THE POWER OF MULTI-LINEAGE CARDIAC STEM CELLS.

Megan Monsanto, San Diego State University, San Diego, California, USA.

Symp. 23: Cardiac energetics in diabetic cardiomyopathy.Chair: Andrew Murray, Cambridge, United Kingdom.Co-chair: Kimberly Mellor, Auckland Bioengineering Institute, Auckland, New Zealand.


PROGRAM BY DAY

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1. NOVEL TARGETS OF INSULIN SIGNALING IN THE HEART - LINKS TO HEART FAILURE.E. Dale Abel, University of Iowa, Iowa, USA.

2. GLYCOPHAGY-A PATHOLOGY OF DERANGED CARDIOMYOCYTE GLYCOGEN HANDLING IN METABOLIC STRESS.Lea Delbridge, University of Melbourne, Melbourne, Australia.

3. DIASTOLIC DYSFUNCTION IN DIABETES MELLITUS.Rebecca Ritchie, Baker IDI Heart & Diabetes Institute, Melbourne, Australia.

4. METABOLIC SYNDROME AND CARDIOVASCULAR DISEASE.Rui-Ping Xiao, Peking University, Beijing, China.

5. ORAL ABSTRACT: SIRT2 CONTRIBUTES TO THE DEVELOPMENT OF HEART FAILURE THROUGH A NRF2 DEPENDENT PATHWAY. Hossein Ardehali, Northwestern University, Chicago, Illinois, USA.

Symp. 24: Mechanisms of progression of heart failure.Chair: Martin LeWinter, UVM Medical Center, Burlington, Vermont, USA.Co-chair: Carlos A. Valverde, Centro de Investigaciones Cardiovasculares Dr. H.E. Cingolani, La Plata, Buenos Aires, Argentina.

1. SMALL MOLECULE INHIBITION OF FIBROTIC SIGNALING FOR HEART FAILURE.Burns Blaxall, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.

2. CARDIOMYOPATHY IN THE SETTING OF MUSCLE DISEASE.Elizabeth McNally, Northwestern University, Chicago, Illinois,USA.

3. DPP4 INHIBITORS AND DIABETIC CARDIOMYOPATHY.Toyoaki Murohara, Nagoya University, Nagoya, Japan.

4. SOLUBLE EPOXIDE HYDROLASE ACTIVATION BY S-NITROSATION CONTRIBUTES TO CARDIAC ISCHEMIA-REPERFUSION INJURY.Yi Zhu, Tianjin Medical University, Tianjin, China.

5. ORAL ABSTRACT: LACK OF ESSENTIAL MYOSIN LIGHT CHAIN PHOSPHORYLATION IMPAIRS CARDIAC ABILITY TO ADAPT TO AUGMENTED PHYSICAL DEMAND.Selina Hein, Heidelberg University Hospital, Heidelberg, Germany.

Symp. 25: Inherited cardiomyopathies: from mutation to therapy.Chair: Peter Ferdinandy, University of Szeged, Szeged, Hungary.Co-chair: Vanessa Lima, University of Sao Paulo, Sao Paulo, Brazil.

1. ENZYME REPLACEMENT THERAPY FOR CARDIOMYOPATHY IN BARTH SYNDROME.Michael T. Chin, University of Washington, Seattle, Washington, USA.

2. GENE THERAPY IN HEART FAILURE.Roger Hajjar, Icahn School of Medicine at Mount Sinai, New York, USA.

3. MECHANISMS OF SARCOMERIC DYSFUNCTION IN HCM.Jolanda van der Velden, VU University Medical Center, Amsterdam, Netherlands.

4. THERAPIES FOR INHERITED AND ACQUIRED CARDIOMYOPATHIES.Michael Regnier, University of Washington, Seattle, Washington, USA..

5. ORAL ABSTRACT: ALDA-1 IMPROVES CARDIAC FUNCTION IN THE HEART FAILURE MICE CARRYING HUMAN ALDEHYDE DEHYDROGENASE 2 E487K VARIANT.Vanessa Lima, University of Sao Paulo, Sao Paulo, Brazil.

Section Business Meeting.

ISHR-ES. Servier session.ISHR-ES. General Assembly.

Hackathon Event.

International Council Meeting II.

FISHR Dinner.



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Registration.

Speaker ready room opens.

President´s Distinguished Lecture: Chair: Matt Hori, Osaka Medical Center for Cancer anda Cardiovascular Disease, Osaka, Japan. Thomas Eschenhagen, University of Hamburg, Hamburg, Germany."Modelling heart disease in the dish - chances and challenges".

Coffee break.

Symp. 26: Signal termination in cardiac physiology and disease.Chair: Walter Koch, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.Co-chair: Sudhiranjan Gupta, Texas A&M, Temple, Texas, USA.

1. THE FLIP SIDE: NEUROHORMONAL REGULATION OF CARDIAC PHOSPHATASES.Metin Avkiran, King’s College London, London, United Kingdom.

2. LYSINE DEACETYLATION: OPPOSING ROLES FOR HDAC ISOFORMS IN HYPERTROPHY?Timothy McKinsey, University of Colorado – Denver, Colorado, USA.

3. DISULFIDE BOND REDUCTION: THE MANY FACES OF THIOREDOXIN-1.Junichi Sadoshima, Rutgers New Jersey Medical School, Newark, New Jersey, USA.

4. ISOFORM-SPECIFIC FUNCTIONS OF PHOSPHODIESTERASES.Manuela Zaccolo, University of Oxford, Oxford, United Kingdom.

5. ORAL ABSTRACT: INHIBITION OF MicroRNA-130a PREVENTS ANGIOTENSIN II-INDUCED CARDIAC REMODELING AND IMPROVED CARDIAC FUNCTION.Sudhiranjan Gupta, Texas A&M, Temple, Texas, USA.

Symp. 27: Metabolic inflexibility in heart failure.Chair: Joan Heller Brown, UC-San Diego, California, USACo-chair: Randi Parks, NIH, Bethesda, Maryland, USA.

1. METABOLIC AND PROTEOMIC ANALYSIS OF MITOCHONDRIAL METABOLISM IN HEART FAILURE.Daniel Kelly, Sanford Burnham Prebys Medical Discovery, Orlando, Florida, USA.

2. TARGETING CARDIAC ENERGY METABOLISM AS A THERAPY TO TREAT HEART FAILURE.Gary D. Lopaschuk, University of Alberta, Alberta, Canada.

3. ALTERED DYNAMICS OF PROTEIN AND AMINO ACID METABOLISM IN FAILING HEART.Heinrich Taegtmeyer, UT Health Medical School, Houston, Texas, USA.

4. POST-TRANSLATIONAL MODIFICATION OF MITOCHONDRIAL FUNCTION IN HEART FAILURE.Rong Tian, University of Washington, Seattle, Washington, USA.

5. ORAL ABSTRACT: MICE LACKING THE MITOCHONDRIAL CALCIUM UNIPORTER HAVE ALTERATIONS IN F1F0-ATP SYNTHASE.Randi Parks, NIH, Bethesda, Maryland, USA.

Symp. 28: Diastolic Dysfunction - basic biology and clinical implications.Chair: Rebecca Ritchie, Baker IDI Heart & Diabetes Inst, Melbourne, Australia.Co-chair: Nazha Hamdani, Institute of Physiology, Bochum, Germany.

1. CELLULAR AND MOLECULAR REGULATION OF CARDIAC FIBROTIC REMODELING.Jennifer Davis, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.

2. CARDIAC ISOFORM EXPRESSION - A PERSONALIZED AND SYSTEMS APPROACH TO DIASTOLIC HEART FAILURE.Michael Gotthardt, Max-Delbrük-Center for Molecular Medicine, Berlin, Germany.

THURSDAYth21

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MAP OF THE VENUE´S SURROUNDINGS



Universidad Católica Argentina, Av. Alicia Moreau de Justo 1300Hotel Madero, Dique 2, Rosario Vera Peñaloza 360BarbaRoja Bar, Defensa 550Piazzolla Tango Florida 165, Galería GüemesEstilo Campo Av Alicia Moreau de Justo 1840

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thTUESDAY 19 April 2016 - XXII ISHR WORLD CONGRESS - Buenos Aires, Argentina

17.00 Coffee break - Foyer Juan Pablo II 2nd floor


11.00 ResearchAchievement Award

Symp 9Chagas, a not so neglected tropical disease

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Symp 4Cardiac hypertrophy and failure

Symp 3Mechanisms of calcium leak-induced arrhythmias

Symp 2Epigenetics of heart failure

14.30 Opening ceremony

15.00 K.ReimerDistinguishedLecture Award

18.15 Outstanding Inv.Award

19.30Welcome Reception

Juan Pablo II conference room & Foyer

Symp 8Novel mechanisms incardiomyopathy

Symp 7Macromolecular complexes, compartmentation signaling and cardiac arrhythmia

Symp 6Cardiac metabolismin heartfailure

8.30 Symp 5The mitochondrialcalcium domainin cardiacpathology

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Symp 17Novel regulatory pathways of cardiac metabolism

Symp 13Modulation oftranscription in cardiovascular development anddisease

Symp 12Regeneration -postnatal versusadult repair

Symp 16Inhibiting nodalsignalling pathways as novel approaches to treating heart failure

Symp 11Intracrine signalling in the heart

Symp 15Hypertension & Hypertrophy

15.00 Symp 10Oxidative strees and inflammation in heart failure

17.30 Symp 14Novel mitochondrialtargets for treatingcardiovasculardisease

thMONDAY 18 April 2016 - XXII ISHR WORLD CONGRESS - Buenos Aires, Argentina

8.30 ECI Symposium 1

10.20 ECISymposium 2

10.00 Coffee

11.50 Coffee12.10 ECI - Career Dev. Panel

nd13.00 Lunch & networking with ECI - Foyer Juan Pablo II 2 floor

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PROGRAM AT A GLANCE

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thWEDNESDAY 20 April 2016 - XXII ISHR WORLD CONGRESS - Buenos Aires, Argentina

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Symp 21Signaling in myocardial regeneration

Symp 20Calcium regulation: from physiology to cardiomyopathy

Symp 19Role of mitochondria in cell death

8.30 Symp 18New molecular Insights of GPCR signaling in the heart

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Symp 25Inherited cardiomyopathies: From mutation to therapy

Symp 24Mechanisms of progression ofheart failure

Symp 23Cardiac energetics in diabetic cardiomyopathy

15.00 Symp 22Making Cardiac regeneration happen-roadblocks to overcome

11.00 NobelLaureate Lecture

12.00 GeneralAssembly & Dist.Leader Award

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st THURSDAY 21 April 2016 - XXII ISHR WORLD CONGRESS - Buenos Aires, Argentina

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10.00 Symp 26Signal termination in cardiac physiology and disease

Symp 27Metabolic inflexibility in heart failure

Symp 28Diastolic Dysfunction-basic biology and clinical implications

Symp 29Regulation of autophagy and cell death pathways in health and disease

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16.30 Symp 30Novel mitochondrial localization and function of signal transducers

Symp 31New Insights into the role of CaMKII in the heart

Symp 32Novel mechanisms and therapeutic targets for arrhythmias

Symp 33Mechanical forces and calcium microdomains

20.00Gala Dinner

17.00 - 22.00Hackathon Event



BARBAROJA BAR - San TelmoECI´s Social Meeting - Tuesday 19th - 20:00 hs This establishment is the first bar opened by the renown Barbaroja brand of beer. Production takes place locally, near Escobar in the Province of Buenos Aires. BarbaRoja has been producing beer since 2001.

The bar is located in the heart of the San Telmo neighborhood and has been declared a historic monument (heritage) of the City of Buenos Aires. The building was the home of Eduardo Madero, the designer of the original Buenos Aires Port, and was built around the same time as the Port.

The bar is organized in the form of an art gallery, with a set of "gazebos" and tables where patrons can enjoy drinks. The restoration of the walls, structures, and ceilings allow guests to appreciate the methods and materials used in the construction of this historic building.

Barbaroja is a high quality beer that would be enjoyable to all beer enthusiasts. Produced with the best-quality local ingredients, it is well-known for its flavor across a wide variety of types of beers, from the more traditional Lager, Pale Ale, and Stout (Trigueña) to the more exotic Lemon beer (Lager with lemon juice), Fruit-flavored beer (black beer with raspberry), Green beer (Lager with green spices), and Floral beer (Pale Ale with a flavor of natural flowers). All in all, BarbaRoja currently offers 16 varieties of beer and, in this way, provides ample opportunity for experiencing the enticing world of craft beers.

PIAZZOLLA Tango - Eventos- San TelmoGala Dinner - Thursday 21th - 20:00 hs A unique space specially set up to hold musical events. It is part of the traditional Galeria Guemes, located in 165 Florida Street, and was first opened to the public on December 15, 1915. It includes a theater venue, Teatro Astor Piazzolla and a coffee place, the Salon Cafe Triunfal, a sophisticated and elegant space in the style of "Art Nouveau."

A second theatre, Belle Epoque, recently renovated with luxury accommodation and perfect acoustic, is the perfect place to spend the evening and to enjoy a time to remember.

The majestic dinner show, with live music, dancing professionals, and excellent singers, combine with the exquisite dishes being served to make your evening a magic time, mixed with the spirit and the memories of Buenos Aires, Astor Piazzolla, and the Tango.

The Piazzolla Sextet, together with an excellent ballet company and some of the best argentine singers deliver a unique performance every night, featuring the piece "Las Cuatro Estaciones del Tango" (the Four Seasons of Tango), by Astor Piazzolla and music by other renown argentine composers.

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3. DETERMINANTS OF DIASTOLIC DYSFUNCTION IN HFpEF.Martin LeWinter, UVM Medical Center, Burlington, Vermont, USA.

4. ROLE OF cMyBP-C IN DIASTOLIC DYSFUNCTION.Sabine J. van Dijk, Institute for Cardiovascular Research, Amsterdam, Netherlands.

5. IMPACT OF CGMP-PKG PATHWAY MODULATION ON TITIN PHOSPHORYLATION AND TITIN-BASED MYOCARDIAL PASSIVE STIFFNESS.Nazha Hamdani, Institute of Physiology, Bochum, Germany.

Symp. 29: Regulation of autophagy and cell death pathways in health and disease.Chair: Lorrie Kirshenbaum, University of Manitoba, Winnipeg, Canada.Co-chair: Hiroshi Akazawa, University of Tokyo, Tokyo, Japan.

1. MITOPHAGY AND BIOGENESIS: PARADOXICAL RESPONSE TO ISCHEMIA.Roberta Gottlieb, Cedars-Sinai Heart Institute, Los Angeles, California, USA.

2. IMPORTANCE OF MITOCHONDRIAL QUALITY CONTROL IN THE MYOCARDIUM.Asa Gustafsson, University of California-San Diego, California, USA.

3. INTERPLAY BETWEEN AUTOPHAGY, APOPTOSIS AND NECROSIS PATHWAYS.Lorrie Kirshenbaum, University of Manitoba, Winnipeg, Canada.

4. MITOCHONDRIAL DEGRADATION AND INFLAMMATION IN FAILING HEARTS.Kinya Otsu, King’s College, London, United Kingdom.

5. ORAL ABSTRACT: ABNORMAL TRAFFICKING OF CONNEXIN 43 ON MICROTUBULES PARTICIPATES TO THE DEVELOPMENT OF LMNA-RELATED DILATED CARDIOMYOPATHY.Coline Macquart, INSERM, Paris, France.

Janice Pfeffer Distinguished Lecture:Chair: Martín Vila Petroff, Centro de Investigaciones Cardiovasculares Dr. H.E. Cingolani, La Plata, Buenos Aires, Argentina. Edward Lakatta, NIA, NIH, Baltimore, Maryland, USA.“The heartbreak of aging viewed from the angiotensin II-remodeled arterial wall”.

Posters Session & Lunch.

Peter Harris Distinguished Scientist Award: Chair: John Solaro,University of Illinois, Illinois, USA.Donald Bers, UC-Davis, Davis, California, USA.“Calmodulin and CaMKII in heart failure and arrhythmias”.

Coffee break.

Symp. 30: Novel mitochondrial localization and function of signal transducers.Chair: Peipei Ping, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.Co-chair: Eliana C. Martinez, University of Miami Miller School of Medicine, Miami, Florida, USA.

1. NOVEL MITOCHONDRIAL LOCALIZATION AND FUNCTION OF SIGNAL TRANSDUCERS.Rainer Schulz, Justus Liebig University, Giessen, Germany.

2. G PROTEINS AND MITOCHONDRIAL FUNCTION.Joan Heller Brown, University of California-San Diego, California, USA.

3. THE DYNAMIC MITOCHONDRIAL PROTEOME.Peipei Ping, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.

2+4. MITOCHONDRIA Ca AND cAMP SIGNALING.Tulio Pozzan, University of Padova, Padova, Italy.

5. ORAL ABSTRACT: TARGETING OF MUSCLE A-KINASE ANCHORING PROTEIN Β-RSK3 COMPLEXES PRESERVES CARDIAC STRUCTURE AND FUNCTION FOLLOWING MYOCARDIAL INFARCTION.Eliana C. Martinez, University of Miami Miller School of Medicine, Miami, Florida, USA.



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Symp. 31: New insights into the role of CaMKII in the heart.Chair: Johannes Backs, University of Heidelberg, Heidelberg, Germany.Co-chair: Javier Duran, University of Chile, Santiago de Chile, Chile.

1. REDOX REGULATION OF CaMKII AND MITOCHONDRIAL FUNCTION.Mark E. Anderson, John Hopkins University, Maryland, USA.

2. PATHWAYS OF CaMKII ACTIVATION IN THE HEART. PHYSIOLOGICAL AND PATHOLOGICAL CONSEQUENCES.Julieta Palomeque, Centro de Investigaciones Cardiovasculares Dr. H.E. Cingolani, La Plata, Buenos Aires, Argentina.

3. THE TANGO BETWEEN PKA AND CaMKII SIGNALING IN CARDIAC PACEMARKER.Yael Yaniv, Israel Institute of Technology, Haifa, Israel.

4. ROLE OF PHOSPHOLAMBAN ABLATION IN CaMKII-INDUCED ARRHYTHMIAS AND CARDIAC DAMAGE.Alicia Mattiazzi, Centro de Investigaciones Cardiovasculares Dr. H.E. Cingolani, La Plata, Buenos Aires, Argentina.

5. ORAL ABSTRACT: TESTOSTERONE ACTIVATES MEF2 THROUGH CaMKII AND ANDROGEN RECEPTOR TO INDUCE CARDIOMYOCYTE HYPERTROPHY.Javier Duran, University of Chile, Santiago de Chile, Chile.

Symp. 32: Novel mechanisms and therapeutic targets for arrhythmias.Chair: Livia Hool, The University of Western Australia, Crawley, Australia.Co-chair: David Hassel, Heidelberg University Hospital, Heidelberg, Germany.

1. FUNCTIONAL AND STRUCTURAL ATRIAL REMODELING IN DISEASE.Katharine Dibb, Institute of Cardiovascular Sciences, Manchester, United Kingdom.

2. REDOX REGULATION OF RyR2.Paulina Donoso, University of Chile, Santiago de Chile, Chile.

3. PHOSPHOLAMBAN IN ARRHYTHMOGENIC CARDIOMYOPATHY: A NEW SURPRISE.Litsa Kranias, University of Cincinnati–College of Medicine, Cincinnati, Ohio, USA.

4. T-TUBULE AND RYANODINE RECEPTOR MICRODOMAINS IN ISCHEMIC HEART DISEASE.Karin Sipido, Katholieke Universiteit – Leuven, Belgium.

5. ORAL ABSTRACT: miR-19b DEFICIENCY IMPAIRS CARDIAC REPOLARIZATION IN ZEBRAFISH.Alexander Benz, University Hospital, Heidelberg, Germany.

Symp. 33: Mechanical forces and calcium microdomains.Chair: Xander Wehrens, Baylor College of Medicine, Houston, Texas, USA. Co-chair: Luis Gonano, Centro de Investigaciones Cardiovasculares Dr. H.E. Cingolani, La Plata, Buenos Aires, Argentina.

1. MEASURING CALCIUM MICRODOMAINS IN THE INTACT HEART.Ariel Escobar, University of California-Merced, California, USA.

2. CALCIUM TRANSPORT IN HUMAN ATRIAL MYOCYTES.Rosana Bassani, University of Campinas, São Paulo, Brazil.

3. INTRACELLULAR CALCIUM REGULATION BY CARDIAC STRETCH.Gustavo Pérez, Centro de Investigaciones Cardiovasculares Dr. H.E. Cingolani, La Plata, Buenos Aires, Argentina.

4. CALCIUM MICRODOMAINS ORGANIZED BY JUNCTOPHILINS.Long Sheng Song, University of Iowa, Iowa City, Iowa, USA.

5. ORAL ABSTRACT: RUNX1 DEFICIENCY IMPROVES CARDIOMYOCYTE FUNCTION POST-MYOCARDIAL INFARCTION.Charlotte McCarroll, University of Glasgow, Glasgow, United Kingdom.

GALA DINNER

THURSDAYth21

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PROGRAM BY DAY

38

nd stPosters are located in the Juan Pablo II (b) (2 floor) and Reading Room (1 floor).Poster hanging 8:00-9:00 AM / Poster removing 6:00-7:00 PMUnclaimed posters will not be stored and will be discarded at the end of the Congress.

Poster distribution

TUESDAY, April 19, 12:00-1:30 PM

Metabolism/Obesity/Diabetes

TU-001 SM22α Ubiquitination Promotes G6PD Activation and NADPH Production, Contributing to GSH 1 1 1 1 1Homeostasis and VSMC Survival Li-Hua Dong , Sui-Bing Miao , Qian-Qian Pei , Mei Han , Department of

Biochemistry and Molecular Biology, College of Basic Medicine, Key Laboratory of Medical Biotechnology of Hebei Province, Key Laboratory of Neural and Vascular Biology of Ministry of Edu, Shijiazhuang, China

TU-002 PGE promotes biliary cholesterol excretion and attenuates diet-induced atherosclerosis by activation of 21 1 1 1EP3-mediated HNF4α/CYP7A1 pathway in liver Shuai Yan , Juan Tang , Yuanyang Wang , Shengkai Zuo ,

1 1 1 1 1Guilin Chen , Jian Zhang , Di Chen , Ying Yu , Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China

TU-003 Protective Effect of Omega-3 Polyunsaturated Fatty Acid in Myocardial Infarction in Mice-- A 1 2 2 2 2 1,2Metabolomics Based Study. Xuan Fang , Xu Zhang , Ding Ai , Chun Jiong Wang , Jin Long He , Yi Zhu ,

1 2Peking University Health Science Center, Beijing, China, Tianjin Medical University, Tianjin, China

TU-004 A Comparative Study on High-Fat Diet Induced Metabolic Abnormalities in Male and Female C57BL/6 1 1 1Mice. Mukesh Nandave , Anup Ramdhave , Dept. of Pharmacology SPP School of Pharmacy and

Technology Management SVKM's NMIMS University, Mumbai, Maharashtra, India1TU-005 Role of hyperhomocysteinemia in Alzheimer's neurodegeneration and the protections. Jianzhi Wang ,

1Tongji Medical College, Wuhan, China1 1TU-006 Bilirubin mediates heme oxygenase-1-induced vascular benefits in diabetic mice. Yu Huang , Jian Liu ,

1Chinese University of Hong Kong, Hong Kong, China1 1TU-007 Inhibition of miR-92a Improves Endothelial Function in Diabetes. Lingshan Gou , Jiangyun Luo , Lei

1 1 1 1 1Zhao , Li Wang , Chi Wai Lau , Yu Huang , Chinese University of Hongkong, Hongkong, China

TU-008 MicroRNA-18a suppresses LXRb expression in human neuroblastoma cells and hepatocytes. Dandan 1 1 1 1Shang , Xin xin , Mei Han , Hebei Medical University, Shijiazhuang, Hebei province, China

TU-009 Phosphodiesterase-5 inhibition protects against the development of diabetic cardiomyopathy in type-1 1 1 1 12 diabetes mellitus. Tamás Radovits , Csaba Mátyás , Balázs Tamás Németh , Attila Oláh , Mihály Ruppert ,

1 1 1 1 2 1 1Dalma Kellermayer , Marianna Török , Lilla Szabó , Alex Ali Sayour , Gábor Szabó , Béla Merkely , Heart and 2Vascular Center, Semmelweis University, Budapest, Hungary, Department of Cardiac Surgery, University of

Heidelberg, Heidelberg, Germany

TU-010 Central Body Fat Distribution Attenuates Heart Rate Recovery after Maximal Exercise in Young Healthy 1 2 1 1Obese Women. Wanda R P Lopes-Vicente , Felipe X Cepeda , Maria F Hussid , Kátia De Angelis , Simone

1 1 1,2 1,2 1Dal Corso , Fernanda C Lanza , Fernanda M Consolim-Colombo , Ivani C Trombetta , Universidade Nove 2de Julho, São Paulo, São Paulo, Brazil, Heart Institute, University of Sao Paulo, São Paulo, São Paulo, Brazil

TU-011 Deficiency of Annexin-A1 Exaggerates Diabetic Cardiomyopathy in a Mouse Model of Type 1 Diabetes. 1,2 1,3 1 1 4 4 1Cheng Xue Qin , Sarah Rosli , Helen Kiriazis , Minh Deo , Eric F Morand , Yuan H Yang , Xiao-Jun Du , Rebecca

1,4 1 2H Ritchie , Baker IDI Heart and Diabetes Institute, Melbourne, Australia, Department of Pharmacology, 3University of Melbourne, Melbourne, Australia, Department of Medicine (Central Clinical School), Monash

4University,, Melbourne, Australia, Centre of Inflammatory Diseases, Monash University, Clayton, Australia

TU-012 β-adrenergic and AMPK signaling regulates cardiomyocyte glycogen autophagy in metabolic stress 1,2 1 2 1 2 1settings. Kimberley Mellor , Vicky Benson , Upasna Varma , Ellie Stevens , Lea Delbridge , University of

2Auckland, Auckland, New Zealand, University of Melbourne, Victoria, Australia

TU-013 Aromatase expression in the myocardium and pericardial adipose – a potential arrhythmogenic 1 1 1 2 3modulator? Gabriel Bernasochi , James Bell , Wendy Ip , Wah Chin Boon , Salvatore Pepe , Jonathan

4 1 1 1Kalman , Stephen Harrap , Lea Delbridge , Department of Physiology, University of Melbourne, Melbourne, 2Victoria, Australia, The Florey Institute of Neuroscience, University of Melbourne, Melbourne, Victoria,

3Australia, Murdoch Children's Research Institute, Department of Paediatrics, University of Melbourne, 4Melbourne, Victoria, Australia, Department of Cardiology, Royal Melbourne Hospital and the Department of

Medicine, University of Melbourne, Melbourne, Victoria, Australia

TU-014 Effects of perindopril on cardiovascular function in middle- aged diet-induced rat models of the

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39

Tuesday, April 1912:00-1:30 PM

Wednesday, April 201:00-3:00 PM

Thursday, April 211:00-3:00 PM

Juan Pablo II (b) Reading Room

TU-001 to TU-057

WE-001 to WE-049

TH-001 to TH-053

TU-061 to TU-103

WE-061 to WE-105

TH-061 to TH-099

1 1 1 1metabolic syndrome. Andrew Fenning , Kylie Connolly , Fiona Coulson , CQUniversity, North Rockhampton, Qld, Australia

1 2TU-015 Protein content of serum exosomes are correlated to atherosclerosis. Jing Quan , Mei Jiang , Sifeng 1 1Chen , Department of Physiology and Pathophysiology, College of Basic Medical Sciences, Fudan

2University, Shanghai, China, Dept. of Neurology, Gongli Hospital, Shanghai, China

TU-016 Common Variation in WNK1 and Blood Pressure Responses to Dietary Sodium or Potassium 1 1 1 1Interventions: A Family–Based Association Study. Jianjun Mu , Fuqiang Liu , Chao Chu , Tongshuai Guo ,

1 1Zuyi Yuan , Cardiovascular Department, First Affiliated Hospital of Xi'an Jiaotong University, Xian, China

TU-017 High Salt Intake Fail to Enhance Plasma Adiponectin in Normotensive Salt-Sensitive Subjects. Jianjun 1 1 1 1 1 1Mu , Fuqiang Liu , Tongshuai Guo , Chao Chu , Zuyi Yuan , Department of Cardiology, First Affiliated Hospital

of Xian Jiaotong University, Xian, China

TU-018 Effects of renin-angiotensin system inhibitors on renal expression of renalase in Sprague-Dawley rats fed 1 1 1 1 1 1with high salt diet. Jianjun Mu , Yang Wang , Wenling Zheng , Yongbo Lv , Yumeng Cao , Jiawen Hu , Tongshuai

1 1 1Guo , Chao Chu , Department of Cardiology, First Affiliated Hospital of Xian Jiaotong University, Xian, China

TU-019 Efficacy and safety of losartan/amlodipine single pill versus free combination at the same dose in hypertensive 2 1 1 1patients with metabolic syndrome. Aniskhon Alyavi , Jamol Uzokov , Bekzod Karimov , Akmal Khudoykulov ,

1 1 1 2Gulnoza Sultonova , Manzura Uzoqova , Tashkent Medical Academy, Tashkent, Uzbekistan, JSC «Republican specialized scientific-practical medical center of therapy and medical rehabilitation», Tashkent, Uzbekistan

TU-020 Cardiogenetics Mapping of Cardiovascular Diseases and Using Those Variants as a Biomarker. Mahmut 1 3 2 4 5 1 1Cerkez Ergoren , Esra Ozerkman , Sehime G. Temel , Çetin Lütfi Baydar , Cenk Conkbayır , Gamze Mocan , Near

2East University, Faculty of Medicine, Department of Medical Biology, Nicosia, Cyprus, Near East University, Faculty 3of Medicine, Department of Embryology and Histology, Nicosia, Cyprus, Near East University Hospital,Medical

4Genetics Laboratory, Nicosia, Cyprus, Near East University, Faculty of Medicine, Department of Forensic Medicine, 5Nicosia, Cyprus, Near East University, Faculty of Medicine, Department of Cardiology, Nicosia, Cyprus

TU-021 Enhanced CD34 expression was an potential independent prognostic factor for breast cancer. 1 1 1 1 1 1 1Shenhua Xu , Zhanhong Chen , Weizhen Xu , Zhiqiang Ling , Gu Zhang , Lei Lei , Xiying Shao , Xiaojia

1 1Wang , Zhejiang Cancer Hospital, Hangzhou, China1TU-022 High fat diet increases the activity of cardiac ryanodine receptors in lipid bilayers. Luis Montecinos ,

1 1 1 1 1 1Jose Finkelstein , Genaro Barrientos , Jaime Riquelme , Paola Llanos , Gina Sanchez , Ricardo Bull , Paulina 1 1Donoso , Instituto de Ciencias Biomedicas. Facultad de Medicina. Universidad de Chile, Santiago, Chile

TU-023 Tetrahydroxystilbene glucoside inhibits excessive autophagy and improves microvascular 1endothelial dysfunction in prehypertensive spontaneously hypertensive rats. Qianqian Dong , Siwang

1 1 1Wang , Haifeng Zhang , Fourth Military Medical University, Xi'an, China

TU-024 The effects of epicatechin on vascular smooth muscle cells in an animal model of obesity. Kirsty 1 1 1 1MacRae , Rebecca Vella , Andrew Fenning , Central Queensland University, Rockhampton, Australia

TU-025 The lack of Toll Like Receptor 4 did not prevent the diabetes-induced cardiac electrical changes. Maria 1 1 1 1Micaela Lopez Alarcon , Maria Julieta Fernadez Ruocco , Gustavo Monerrat-Calhi , Emiliano Medei ,

1Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Brazil1TU-026 Carbonic anhydrase and ion transporters in diabetic cardiomyopathy. Carolina Jaquenod De Giusti ,

2 1 1 1Paula G. Blanco , Juan M. Lofeudo , Bernardo V. Alvarez , Centro de Investigaciones Cardiovasculares Dr. 2H.E. Cingolani, La Plata, Buenos Aires, Argentina, Facultad de Ciencias Médicas, Universidad Nacional de La

Plata, La Plata, Bs As, Argentina

TU-027 High intensity exercise reduces fibrosis and hypertrophy but not oxidative stress in diabetic 1 1 1 1 1cardiomyopathy. Ulises Novoa , Diego Arauna , Carmen Zambrano , Madelaine Nuñez , Daniel Gonzalez ,

1Universidad de Talca, Talca, Chile1TU-028 Secondary (symptomatic) hypertension in patients with metabolic syndrome. Ramiz Abdulgasanov ,

1 1 1 1 1Sanchez Sebastian , Alexey Ivanov , Mehriban Abdulgasanova , Aslan Ordokov , Scientific center of cardiovascular surgery named after A. N. Bakulev, Moscow, Russia

TU-029 The impact of diabetes mellitus on miR expression of patients with or without heart failure. Raiana 1 1 2 1 1Barbosa , Bruna Farjun , Alexandre Siciliano , Adriana Carvalho , Federal University of Rio de Janeiro, Rio

2de Janeiro/RJ, Brazil, National Institute of Cardiology, Rio de Janeiro/RJ, Brazil

TU-030 Nitric oxide bioavailability in rats with metabolic syndrome: effect of (–)-epicatechin in the heart. 1 1 1 2 1Barbara Piotrkowski , Valeria Calabró , Laura Fischerman , Marcela Vazquez-Prieto , Monica Galleano ,

1 1 Cesar Fraga , Physical chemistry-IBIMOL, University of Buenos Aires-CONICET, Buenos Aires, Argentina,2Dept of Pathology-IMBECU, University of Cuyo-CONICET, Mendoza, Argentina

TU-031 Characterization of the CYP2C19*2 allelic variant distribution in Chilean coronary disease patients. 1 1 1 1 1 2Jenny Ruedlinger , Valena Prado , Nicolás Saavedra , Fernando Lanas , Braulio Bobadilla , Luis Perez , Luis

1 1 2A. Salazar , Universidad de la Frontera, Temuco, Chile, Universidad de Concepción, Concepción, Chile

Signaling Mechanisms

TU-032 Inhibition of phosphoinositide 3-kinase γ promotes cardiac mitophagy and prevents anthracycline-

POSTER SESSIONS

40

1 1 1 2related cardiomyopathy. Alessandra Ghigo , Mingchuan Li , Maria Chiara De Santis , Nicola Pianca , Irene 1 3 4 2 2 2 1Franco , Sebastiano Sciarretta , Fulvio Morello , Marco Sandri , Tania Zaglia , Marco Mongillo , Emilio Hirsch ,

1Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of 2Torino, Torino, Italy, Department of Biomedical Sciences and Venetian Institute of Molecular Medicine,

3University of Padova, Padova, Italy, Department of Medical and Surgical Sciences and Biotechnologies, 4University of Rome "Sapienza", Latina, Italy, S.C. Medicina d'Urgenza A.O. Città della Salute e della Scienza

di Torino, Torino, Italy

TU-033 Oxidative Activation of cAMP-dependent Protein Kinase by Nitroxyl modulates Myofilament Protein 1 1 1 2 1Phosphorylation. Simon Diering , Mara Goetz , Sophie Schobesberger , Sebastian Pasch , Sonia Donzelli ,

1 1 3 4 2Konstantina Stathopoulou , Angelika Piasecki , Bruce King , Viacheslav Nikolaev , Susanne Lutz , Philip 5 1 1Eaton , Friederike Cuello , Department of Experimental Pharmacology and Toxicology, University Medical

Center Hamburg-Eppendorf; Cardiovascular Research Center; DZHK partner site Hamburg/Lübeck/Kiel, 2Hamburg, Germany, Institute of Pharmacology, University Medical Center Göttingen, Georg-August

3University Goettingen, Göttingen, Germany, Department of Chemistry, Wake Forest University, Winston- 4Salem, North Carolina, USA, Institute of Experimental Cardiovascular Research , University Medical Center

5Hamburg-Eppendorf, Hamburg, Germany, King's College London, Cardiovascular Division, The British Heart Foundation Centre of Excellence, The Rayne Institute, St Thomas' Hospital, London, SE1 7EH, UK

TU-034 Testosterone activates MEF2 through CaMKII and androgen receptor to induce cardiomyocyte 1 1 1 1hypertrophy. Javier Duran , Daniel Lagos , Manuel Estrada , Universidad de Chile, Santiago, RM, Chile

1TU-035 Acetylation of SERCA2a inhibits its function and is modulated by SIRT1. Changwon Kho , Dongtak 1 1 2 1 1 1 2Jeong , Ahyoung Lee , Seung Pil Jang , Dong Kwon Yang , Przemek Gorski , Jae Gyun Oh , Woo Jin Park ,

1 1Roger Hajjar , Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, 2USA, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea

TU-036 Contribution of serotonin 5-HT receptors to the mobilization of bone marrow endothelial progenitors 2B1 1 1in cardiac valve degeneration. Roland Lawson , Estelle Ayme-Dietrich , Houda Bouhadja , Claudia De

1 2 2 3 2 4Tapia , Helène Rouillard , Jordane Stoltz , Sophie Banas , Bernard Gasser , Jean-Phillipe Mazzucotelli , Luc 3 1 1Maroteaux , Laurent Monassier , Laboratory of Neurobiology and Cardiovascular Pharmacology (Faculty of

2Medicine EA 7296), Strasbourg, France, Laboratoire de Pathologie (Centre Hospitalier Emile Muller), 3 4Mulhouse, France, Institut du Fer à Moulin (Inserm UMR S-839), Paris, France, Service de chirurgie

cardiaque (Centre Hospitalier de Strasbourg), Strasbourg, France

TU-037 Metformin attenuates angiotensin II induced transforming growth factor-β1 production through the 1 1 1 1inhibition of HNF4α by AMPK activation. Han Xiao , Ruifei Chen , Youyi Zhang , Institute of vascular

medicine, Peking University Third Hospital, Beijing, China

TU-038 Chronic inflammation inhibits myofibroblast activation through macrophage Ccl12 secretion. Kristine 1 1 1 1 1DeLeon-Pennell , Rugmani Padmanabhan Iyer , Courtney Cates , Elizabeth Flynn , Yonggang Ma , Presley

1 1 2 3 1,4 1Cannon , De'Aries Shannon , Michael Garrett , William Buchanan , Merry Lindsey , Mississippi Center for Heart Research, Department of Physiology and Biophysics, University of Mississippi Medical Center,

2 Jackson, USA, Department of Pharmacology, University of Mississippi Medical Center, Jackson, USA,3Department of Periodontics and Preventative Science, University of Mississippi Medical Center, Jackson,

4USA, Research Service, G.V. (Sonny) Montgomery Veterans Affairs Medical Center, Jackson, USA

TU-039 HnRNPA1 regulates neointima formation through modulating vascular smooth muscle cell functions. 1 1 2 1 1 2 1 2Qishan Chen , Yuan Huang , Guanmei Wen , Mei Yang , Bing Dai , Le Luong , Jianhua Zhu , Qingzhong Xiao ,

1 1 Li Zhang , First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China,2Queen Mary, University of London, London, UK

1 1 1TU-040 Bach1 represses Wnt/b-catenin signaling and angiogenesis. Dan Meng , Li Jiang , Xiangxiang Wei , 1 1 1 2 0 1 2Junxu Liu , Cong Niu , Xie Xu , Jianyi Zhang , Sifeng Chen , Fudan University, Shanghai, China, University of

Minnesota Medical School, Minneapolis, USA1TU-041 Kruppel-like Factor 2 Mediates the Suppressive Effect of Statin on BMP4-Smad Signaling. Jiang-Yun Luo ,

1 1 1 1 1hongsong Zhang , lingshan Gou , Chi Wai Lau , Yu Huang , The Chinese University of Hong Kong, Hong Kong, China1 1TU-042 A role for antioxidants in reversing Tiotropium induced cardiotoxicity. Shabana Cassambai , Sadie Dean ,

1 1 1 1Christopher J Mee , Katherine L Harvey , Afthab Hussain , Coventry University, Coventry, West Midlands, UK

TU-043 MicroRNA-26a Inhibits Vascular Smooth Muscle Cell Proliferation and Neointimal Hyperplasia by 1 2 3,4 3,4 1Targeting MAPK6. Tan Juanjuan , Yang Liguo , Liu Cuicui , Yan Zhiqiang , School of Life Sciences and

2Biotechnology,Shanghai Jiao Tong university, Shanghai, China, Southern Medical University, Guangzhou, 3 4China, Fengxian Hospital Affiliated to Southern Medical University, Shanghai, China, Sixth People's Hospital

South Campus Affiliated to Shanghai Jiao Tong University, Shanghai, China1,2 1TU-044 New insights into adrenergic regulation of cardiac remodelling. Youyi Zhang , Institute of Vascular

2Medicine,Peking University Third Hospital, Beijing, China, Beijing Key Laboratory of Cardiovascular 3Receptors Research, Beijing, China, Key Laboratory of Cardiovascular Molecular Biology and Regulatory

Peptides, Ministry of Health, China1 1 1TU-045 ER stress mediates cardiac ion channel changes in heart failure. Man Liu , Guangbin Shi , Anyu Zhou ,

1 1Samuel C. Dudley , Rhode Island Hospital and Brown University, Providence, RI, USA



TU-046 The neuro-cardiac interaction defines an extracellular microdomain required for neurotrophic 1,2 1,2 1,2 3 1,2 1signalling. Mauro Franzoso , Tania Zaglia , Nicola Pianca , Libero Vitiello , Marco Mongillo , Venetian

2Institute of Molecular Medicine, Padova, Italy, Department of Biomedical Sciences, University of Padova, 3Padova, Italy, Department of Biology, University of Padova, Padova, Italy

TU-047 Chronic lead exposure impairs vascular reactivity through oxidative stress dependent mechanism: MAPKs 1 1 1 1 3pathway activation. Maylla Simões , Bruna Azevedo , Jonaina Fiorim , Cindy Toscano , Mercedes Salaices ,

1,2 1 2Dalton Vassallo , Universidade Federal do Espírito Santo, Vitória, ES, Brazil, EMESCAM-Escola Superior de 3Ciências da Santa Casa de Misericórdia de Vitória, Vitória, ES, Brazil, Universidad Autónoma Madrid, Madrid, Spain

1TU-048 mTORC1 and mTORC2 preserve cardiac function by regulating metabolism and contractility. Lifen Xu , 1 1 2 1 1Pankaj Shende , Christian Morandi , Thierry Pedrazzini , Laura Pentassuglia , Sonia Lebboukh , Michael

1 1 1 1 2Hall , Markus A. Rüegg , Marijke Brink , University of Basel, Basel, Switzerland, University of Lausanne Medical School, Lausanne, Switzerland

TU-050 Uncovering novel signaling components for DCM development - a phospho-proteomics approach. 1 1 1 1 1 1 2Stephan Lange , Lauren Waller , Nancy Dalton , Erika Alvarez , Kirk Peterson , Ju Chen , Elisabeth Ehler ,

1 1 2Majid Ghassemian , UC San Diego, La Jolla, CA, USA, King's College London, London, UK

TU-051Beta -adrenergic stimulation induces HDAC5 nuclear accumulation by B55alpha-PP2A-mediated 11 1 1 1 1dephosphorylation. Kate Weeks , Antonella Ranieri , Chris Molenaar , Metin Avkiran , King's College London, London, UK

TU-052 Identification of a high affinity, high efficacy adenosine A receptor agonist with potent anti-fibrotic 2B1 1,2 1 1 2activity. Elizabeth Vecchio , Chung Chuo , Peter Scammells , Arthur Christopoulos , Bing Wang , Henry

2 1 1 1Krum , Paul White , Lauren May , Monash Institute of Pharmacy and Pharmaceutical Sciences, Monash 2University, Parkville, Victoria, Australia, Centre of Cardiovascular Research and Education in Therapeutics,

School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia

TU-053 Catestatin modulates adrenergic signaling and reverses the hypertrophic effects of norepinephrine in 1 2 1 1H9c2 cardiac myoblasts. Md. Jahangir Alam , Nitish R Mahapatra , Shyamal K Goswami , School of Life

2Sciences, Jawaharlal Nehru University, New Delhi, Delhi, India, Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology, Chennai, Madras, India

TU-054 Protective effect of Aronia melanocarpa on cardiovascular system in L-NAME-induced hypertension. Martina 1 1 1 1 1 1Cebova , Jana Klimentova , Andrej Barta , Zuzana Matuskova , Radoslava Rehakova , Michaela Kosutova , Olga

1 1Pechanova , Institute of Normal and Pathological Physiology Slovak Academy of Sciences, Bratislava, Slovakia1TU-055 Role of NADPH Oxidase-2 under adrenergic stimulation in cardiomyocytes. Nikhat Saleem , Shyamal K

1 1Goswami , School of Life Sciences, Jawaharlal Nehru University, New Delhi, Delhi, India

TU-056 Nitro-oleic acid, a component of the mediterranean diet, prevents MKK3- p38α-MAPK; dimer formation by 1 1 1steric obstruction of redox-sensitive cysteines. Rekha Bassi , Joseph Burgoyne , Gian de Nicola , Olena

1 1 1 1 1 1Rudyk , Vittorio de Santis , Rebecca Charles , Philip Eaton , Michael Marber , King's College London, London, UK1TU-057 The adenosine signalosome requires ROS activation to mediate cardioprotection. Anders O. Garlid , Keith

2 1 1D. Garlid , Peipei Ping , Departments of Physiology, Medicine, and Bioinformatics, University of California, Los 2Angeles, Los Angeles, CA, USA, Department of Biology, Portland State University, Portland, OR, USA

Cardiac Regeneration/Cell Therapies

TU-061 Pluripotent stem cell microRNA-294 as a mediator of cardiac proliferative response in the heart after 1 1 2 1myocardial infarction. Mohsin Khan , Brandon Booth , Constantine Troupes , Emily Nickoloff , Sadia

2 1 2 1 1 1Mohsin , Cynthia Benedict , Steven Houser , Walter Koch , Raj Kishore , Center for Translational Medicine, 2Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA, Cardiovascular Research Institute,

Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA

TU-062 Proliferation of the cardiac precursor cells expressing the Stem Cell Antigen-1 is modulated by 1 1activation of the Natriuretic Peptide Receptors. Stéphanie Rignault-Clerc , Christelle Bielmann , Lucas

2 1 1 1 1Liaudet , Bernard Waeber , François Feihl , Nathalie Rosenblatt-Velin , Departement de Physiopathologie Clinique Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland,

2Service de Médecine Intensive Adulte CHUV, Lausanne, Switzerland

TU-064 Enzymatic degradation of 7-Ketocholesterol (7-KC), a new strategy for the treatment of 1 1Atherosclerosis. Irum Perveen , Quaid-i-Azam University, Islamabad, Pakistan

TU-065 Restoration of prostaglandin E2 levels in the mesenchymal stem cells prevents their rejection in the 1 1ischemic heart and preserves ventricular function. Niketa Sareen , Ejlal Abu-El Rub , Glen Lester

1 1 1 1Sequiera , Meenal Moudgil , Sanjiv Dhingra , Institute of Cardiovascular Sciences, St. Boniface Hospital Research Centre, University of Manitoba, Winnipeg, Canada

TU-066 Upconversion nanoparticle-mediated photodynamic therapy induces THP-1 macrophage apoptosis 1 1and THP-1 macrophage-derived foam cell autophagy via ROS burst. Liming Yang , Zhaoyu Zhong , Xing

1 1 1 1,2 1Zhu , Jiayuan Kou , Xuesong Li , Ye Tian , Department of Pathophysiology, Harbin Medical University, 2Harbin, Heilongjiang Province, China, Division of Cardiology, the First Affiliated Hospital, Harbin Medical

University, Harbin, Heilongjiang Province, China

POSTER SESSIONS

42

TU-067 Bone marrow mesenchymal stem cells reprogrammed into cardiac progenitor cells by nano-protein 1 1 1 1,2 1,2 1transfection bio-unit. Lin Jiang , Xiaohong Li , Yueheng Wu , Yuliang Feng , Xi-Yong Yu , Medical

2Research Center of Guangdong General Hospital, Guangdong, China, Guangzhou Medical University, Guangdong, China

1TU-068 Beta 2 adrenegic receptor expression and activation of endogenous progenitor cells. Amanda Finan , Morgane 1 1 1 1 1 1Guisiano , Patrice Bideaux , Marie Demion , Jerome Thireau , Sylvain Richard , INSERM U1046, Montpellier, France

TU-069 Adult ovine cardiomyocytes express the cell cycle-inhibiting gene Meis1. A potential target for cardiac 1 1regeneration based on cardiomyocyte division. Paola Locatelli , Carlos Sebastián Giménez , Fernanda

1 1 1 2 2 1Daniela Olea , Anna Hnatiuk , Alberto Crottogini , Daniel Ghiringhelli , Mariano Nicolas Belaich , Favaloro 2University, Buenos Aires, Argentina, Quilmes National University, Bernal, Buenos Aires, Argentina

TU-070 High doses of high mobility group box-1 (HMGB1) protein increase capillary and arteriolar densities and induce overexpression of genes involved in angiogenesis and cell proliferation in ovine infarct

1 1 1border zone. Fernanda Daniela Olea , Maria del Rosario Bauzá , Paola Locatelli , Carlos Sebastián 1 1 2 1 1 1Giménez , Anna Hnatiuk , Leonardo Sganga , Luis Cuniberti , Alberto Crottogini , Favaloro University,

2Buenos Aires, Argentina, Leloir Institute, Buenos Aires, Argentina1TU-071 P2Y nucleotide receptor prompts human cardiac progenitor cell activation. Farid Elsayed , Steven 2

1 1 1 1Greene , Jonathan Nguyen , Mark Sussman , San Diego State University, San Diego, California, USA

TU-072 Polylactic acid sheets seeded with genetically modified ovine diaphragmatic myoblasts for myocardial 1 1 1 1regeneration. Carlos Sebastian Giménez , Fernanda Daniela Olea , Paola Locatelli , Anna Hnatiuk , Milagros

2 2 3 3 4 1Pena , Ricardo Dewey , Florencia Montini Ballarin , Gustavo Abraham , Alejandro Orlowski , Luis Cuniberti , 1 1 2Alberto Crottogini , Favaloro University, Buenos Aires, Argentina, IIB- INTECH-UNSAM-CONICET,

3 Chascomus, Buenos Aires, Argentina, INTEMA-UNMDP-CONICET, Mar del Plata, Buenos Aires, Argentina,4Centro de Investigaciones Cardiovasculares Dr. H.E. Cingolani, La Plata, Buenos Aires, Argentina

TU-073 Rapid stabilisation of atherosclerotic plaque with 5-aminolevulinic acid-mediated sonodynamic 1,2 1therapy. Ye Tian , Division of Cardiology, the First Affiliated Hospital of Harbin Medical University, Harbin,

2China, Division of Pathophysiology, Harbin Medical University, Harbin, China

TU-074 Cellular mechanisms of osteogenic differentiation in the development of aortic valve calcification. 1,2 1 2 3,4Mariia Bogdanova , Katarina Zihlavnikova Enayati , Anna Malashicheva , Jarle Vaage , Kåre-Olav

1 1,3 1Stensløkken , Arkady Rutkovskiy , Div. of Physiology, Institute of Basic Medical Sciences, University of Oslo, 2 3Oslo, Norway, Almazov Federal Heart Centre, Saint Petersburg, Russia, Dept. of Emergency and Critical

4care, Oslo University Hospital, Oslo, Norway, Institute of Clinical Medicine, University of Oslo, Oslo, Norway

TU-075 Cortical bone stem cells derived exosomes can promote cardiac repair mechanisms after myocardial 1 1 1 1 1injury. Sadia Mohsin , Constantine Troupes , Mohsin Khan , Timothy Starosta , Hajime Kubo , Remus

1 1 1 1Berretta , Raj Kishore , Steven Houser , Temple University, Philadelphia, USA

TU-076 Detection of serum vascular endothelial growth factor and its clinical significance in lymphoma 1 2 2 1patients. Qian Lijuan , Zhang Meng , Zhang Qingyun , Zhejiang Cancer Hospital, Hangzhou Zhejiang China,

2China, Peking University School of Oncology, Beijing Cancer Hospital, Haidian District, Beijing, China

TU-077 Genome-wide siRNA screening identifies cellular genes regulating AAV transduction in the 1 1,2 1 1cardiovascular system. Lorena Zentilin , Miguel Mano , Edoardo Schneider , Serena Zacchigna , Mauro

1 1 2Giacca , International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy, Center for Neuroscience and Cell Biology (CNC) University of Coimbra, Cantanhede, Portugal

Heart Failure & Hypertrophy

TU-078 Synthetic patches "BASEX" for management of post-infarction aneurysm of heart. Ramiz 1 1 1 1 1Abdulgasanov , Alexey Ivanov , Sanchez Sebastian , Mehriban Abdulgasanova , Scientific center of

cardiovascular surgery named after A. N. Bakulev, Moskow, Russia1,6 4 2 5TU-079 Role of miRNA-33a in dilated cardiomyopathy. Anupam Mittal , Santanu Rana , Rajni Sharma , Vikas Arige ,

2 5 4 3 1 6Sanskriti Khanna , Nitish Mahapatra , Sagartirtha Sarkar , Uma Nahar , Ajay Bahl , Shyamal Goswami , Madhu 2 1 Khullar , Department of Cardiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India,

2Department of Experimental Medicine and Biotechnology, Postgrduate Institute of Medical Education and Research, 3Chandigarh, India, Department of Histopathology, Postgraduate Institute of Medical Education and Research,

4 5Chandigarh, India, Deprtment of Zoology University of Calcutta, Kolkata, India, Department of Biotechnology, Indian 6Institute of Technology, Chennai, India, School of Life Sciences, Jawahar Lal Nehru University, New Delhi, India

TU-080 Symptomatic arterial hypertension: modern methods of diagnosis and treatment (results based on 1 1 1examination of 2050 patients). Ramiz Abulgasanov , Alexey Ivanov , Sanchez Sebastian , Mehriban

1 1Abdulgasanova , Scientific center of cardiovascular surgery named after A. N. Bakulev, Moscow, Russia1TU-082 Increased expression of calreticulin in the heart: cardiac fibrosis and heart failure. Jody Groenendyk ,

1 2University of Alberta, Edmonton, Alberta, Canada, McGill University, Montreal, Quebec, Canada1 1 1TU-083 TRPV2 regulates the development of myocyte hypertrophy. Sheryl Koch , Samuel Slone , Min Jiang ,

1 1 1Michael Tranter , Jack Rubinstein , University of Cincinnati, Cincinnati, OH, USA



TU-084 Normalization of cardiac energy metabolism and left ventricular hypertrophy precede functional 1 1 1recovery in the regression of heart failure. Nikole J Byrne , Jody Levasseur , Miranda M Sung , Grant

1 1 2 1 1Masson , Jamie Boisvenue , Martin E Young , Jason RB Dyck , University of Alberta, Edmonton, Alberta, 2Canada, University of Alabama at Birmingham, Birmingham, Alabama, USA

TU-085 Genetic background does not affect progression to heart failure in a mouse model with genetic 1 1 1ablation of RyR2-S2808A phosphorylation. Francisco J. Alvarado , Hector H. Valdivia , University of

Michigan, Ann Arbor, MI, USA

TU-086 CDK6 mediates the effect of attenuation of miR-1 on provoking cardiomyocyte hypertrophy. Jie ning 1 1 1 1 1 1 1 1Zhu , Chun mei Tang , Qiu xiong Lin , Wen si Zhu , Yong heng Fu , Chun yu Deng , Min Yang , Zhi xin Shan ,

1Guangdong General Hospital, Guangdong Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China

TU-087 The interplay between genetic background and sexual dimorphism of doxorubicin-induced 1 2 1 1 1 1cardiotoxicity. Beshay Zordoky , Judith Radin , Lois Heller , Anthony Tobias , Ilze Matise , Fred Apple , Sylvia

3 1 1 2McCune , Leslie Sharkey , University of Minnesota, Minneapolis, MN, USA, The Ohio State University, 3Columbus, OH, USA, University of Colorado at Boulder, Boulder, CO, USA

1TU-088 Rnd3/RhoE is a Pro-Angiogenic Factor Regulating Responsive Cardiac Angiogenesis. Xiaojing Yue , Xi 1 1 1 1 2 2 1Lin , Tingli Yang , Xiangsheng Yang , Xin Yi , Keith Youker , Guillermo Torre-Amione , Kelsey Andrade , Jiang

1 1 2Chang , Texas A&M University Health Science Center, Houston, Texas, USA, Methodist DeBakey Heart & Vascular Center, Houston, Texas, USA

1 1 1TU-089 Telomeres in cardiac hypertrophy: tails of a broken heart. Scott Booth , Alex Nield , Fadi Charchar , 1Federation University Australia, Mt Helen, Victoria, Australia

TU-090 Improved metabolic function and contractility in mdx mice following treatment with morpholino 1 1 3 3,4 3,4 1,2oligomers. Victoria Johnstone , Helena Viola , Abbie Adams , Steve Wilton , Sue Fletcher , Livia Hool ,

1 2The University of Western Australia, Crawley, Western Australia, Australia, Victor Chang Cardiac Research 3Institute, Sydney, New South Wales, Australia, Centre for Neuromuscular and Neurological Disorders, The

4University of Western Australia, Crawley, Western Australia, Australia, Centre for Comparative Genomics, Murdoch University, Murdoch, Western Australia, Australia

TU-091 Identification of miR-34 regulatory networks in settings of disease and antimiR-therapy: Implications for 1 1 1treating cardiac pathology and other diseases. Jenny Y. Y. Ooi , Bianca C. Bernardo , Saloni Singla , Ruby

2,3 1,4 1 2C.Y. Lin , Julie R. McMullen , Baker IDI Heart & Diabetes Institute, Melbourne, Victoria, Australia, Asbestos 3Diseases Research Institute, Sydney, New South Wales, Australia, Ramaciotti Centre for Genomics, University

4of New South Wales, Sydney, New South Wales, Australia, Monash University, Clayton, Victoria, Australia

TU-092 Cardiac Thyrotropin Releasing Hormone (TRH) inhibition attenuates the post-ischemic damage and 1improves ventricular function after myocardial infarction in rats. Mariano Schuman , Ludmila Peres

1 1 1 1 1 1Diaz , Maia Aisicovich , Fernando Ingallina , Silvina Landa , Silvia García , Laboratory of Molecular Cardiology, Institute of Medical Research A. Lanari, UBA; IDIM-CONICET, Buenos Aires, Argentina

TU-094 Guanylyl Cyclase-A signaling attenuates deleterious salt effect on aldosterone-induced cardiac 1 1 1 1remodeling. Hitoshi Nakagawa , Satoshi Somekawa , Yasuki Nakada , Tomoya Nakano , Takuya

1 1 1 1 1Kumazawa , Kenji Onoue , Hiroyuki Okura , Yoshihiko Saito , Nara Medical University, Nara, Japan

TU-095 The role of fibroblast and endothelial cell NADPH oxidase-2 in the development of cardiac fibrosis. 1 1 1 1 2 2Daniel Richards , Craig Harrison , Greta Sawyer , Heloise Mongue-Din , Stephanie Telerman , Fiona Watt ,

1 1 2Ajay Shah , King's College London - BHF Centre of Excellence, London, UK, King's College London - Centre for Stem Cells & Regenerative Medicine, London, UK

1,2 2TU-096 NADPH oxidase-4 mediates cardiac adaptation to volume overload. Moritz Schnelle , Karl Toischer , 1 1 3 3 2 1 1Norman Catibog , Min Zhang , Katrin Schröder , Ralf Brandes , Gerd Hasenfuss , Ajay Shah , King's College

2 3London BHF Centre, London, UK, Goettingen Heart Centre, Goettingen, Germany, Institut für Kardiovaskuläre Physiologie, Goethe-Universität, Frankfurt am Main, Germany

TU-097 Structural and functional changes in the murine heart during sustained β-adrenergic stimulation in 1 1 1 1 1vivo. Sarah-Lena Puhl , Kate Weeks , Antonella Ranieri , Metin Avkiran , King's College London, London, UK

TU-098 Distinct roles of intracellular calcium release channels in cardiac and vascular remodeling. Gaetano 1 1 1 1 1,2 1 1Santulli , Qi Yuan , Steven Reiken , Jingyi Yang , Alain Lacampagne , Andrew Marks , Columbia University,

2New York, NY, USA, Montpellier University, Montpellier, France

TU-099 Inhibition of Rho Kinase (ROCK) restores ionic currents and prevents electrical remodeling of heart in 1 1 2pressure overload induced hypertrophy model. Murat Cenk Celen , Bilge Eren Yamasan , Yusuf Olgar ,

1 1 2Semir Ozdemir , Akdeniz University, Antalya, Turkey, Ankara University, Ankara, Turkey

TU-100 Restrictive cardiomyopathy mutation TnI-R145W blocks PKA-PKC cross-modulation of human 1 1myofilament length dependent activation and relaxation kinetics. Alexey Dvornikov , Nikolai Smolin ,

1 1 1 0 1Mengjie Zhang , Jody Martin , Seth Robia , Pieter de Tombe , Loyola University Chicgo, Maywood IL, USA1,2TU-101 PGE2-dependent epigenetic pathways in inflammatory cardiomyopathies. Richard Schell , Florian

1 2 1 2 1Leuschner , Andras Toth , Hugo A. Katus , Johannes Backs , University Hospital - Department of Cardiology, 2Angiology and Pneumology, Heidelberg, Germany, University Hospital - Department Molecular Cardiology

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44

and Epigenetics, Heidelberg, Germany1TU-102 Effects of a Selective Class I HDAC inhibitor on cardiac remodeling in mouse TAC. Kersten Small ,

2 1 2 2 1 2 1Joseph McCarthy , Shu Yu Sun , Mark Aronovitz , Richard Karas , Jeffrey Madwed , Robert Blanton , Merck 2Research Labs, Kenilworth, NJ, USA, Tufts Medical School, Boston, MA, USA

TU-103 Direct AMPK Activation Fails to Improve Cardiac Structure and Function in Mouse Pressure-Overload 1 2 2 2 1Heart Failure Model. Kersten Small , Jessica Bradley , Traci Goodchild , Craig Zilblich , Juliann Ehrhart , Shu

1 1 1 2 1 Yu Sun , Iyassu Sebhat , Jeffrey Madwed , David Lefer , Merck Research Labs, Kenilworth, NJ, USA,2Louisiana State University, New Orleans, LA, USA

WEDNESDAY, April 20, 1:00-3:00 PMHeart Failure & Hypertrophy

WE-001 The transactivation activity of glucocorticoid receptor plays a key role in protecting heart against 1 1stress and that is suppressed under pressure-overload. Motoaki Sano , Keio University School of

Medicine, Tokyo, Japan

WE-002 Gentianella acuta Improves Cardiac Function in a Model of Coronary Ligation Induced Heart Failure 1 1via a Mechanism of Against Endoplasmic Reticulum Stress-Associated Autophagy. Yu Liu , Aiying Li ,

1Hebei University of Chinese Medicine, Shijiazhuang,Hebei, China

WE-003 Gentianella acuta prevents isoprenaline-induced myocardial fibrosis in rat by reduction of myocardial 1 2 2 1TGF-β1/ CTGF expression. Aiying Li , Ensheng Ji , Jingjing Wang , Department of Biochemistry, Hebei

2University of Chinese Medicine, Shijiazhuang, Hebei, China, Department of Physiology, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China

WE-004 Phosphodiesterase 3A1 Prevents Cardiac Remodeling from Neurohormonal Activation. Masayoshi 1 1 1 1 1Oikawa , Shoji Iwaya , Shu-ichi Saitoh , Yasuchika Takeishi , Fukushima Medical University, Department of

Cardiology and Hematology, Fukushima, Japan

WE-005 Angiotensin-converting enzyme inhibitor-induced cough prevalence in Resistant Hypertension 1 1 1Patients. André Nascimento Publio Pereira , Adilson Machado Gomes Junior , Camila Barbosa Pereira ,

1 1 1 1Paulo Chenaud Neto , Thiago Matos e Silva , André Oliveira Barbosa , Cristiano Ricardo Bastos de Macedo , 1 1Roque Aras Júnior , Federal University of Bahia, Salvador, Bahia, Brazil

WE-006 Inhibition of class I histone deacetylases blunts cardiac hypertrophy via TSC2-dependent mTOR 1 1 2 1 1 1repression. Cyndi Morales , Dan Li , Zully Pedrozo , Herman I. May , Nan Jiang , Viktoriia Kyrychenko ,

1 1 1 1 1 2Geoffrey Cho , Julia Kim , David Rotter , Beverly A. Rothermel , Jay W. Schneider , Sergio Lavandero , 1 1 1Thomas G. Gillette , Joseph A. Hill , Department of Internal Medicine, UT Southwestern Medical Center,

2Dallas, TX, USA, Facultad Ciencias Químicas y Farmacéuticas & Facultad Medicina, Universidad de Chile, Santiago, Chile

WE-007 Myosin activator improves actin assembly and sarcomere function of human induced pluripotent 1 1stem cell-derived cardiomyocytes with a troponin T point mutation. Kathleen Broughton , Elina Sarmah ,

1 1 1 1 2 1 1Jieli Li , Chad Warren , Ying-Hsi Lin , Marcus Henze , Vero Sanchez-Freire , R. John Solaro , Brenda Russell , 1 2University of Illinois at Chicago, Chicago,IL, USA, Stanford University, Stanford, CA, USA

WE-008 Identification of calpastatin as a novel substrate of p38gamma mitogen activated protein kinase. 1 1 1 1 2 2Aminah Loonat , Eva Denise Martin , Sang Hoon Choi , Francesca Hunt , Nicholas T Hertz , Rebecca Levin ,

2 2 1 1 1 Kevan Shokat , Alma L Burlingame , Michael S Marber , James E Clark , King's College London, London, UK,2University of California, San Francisco, USA

WE-009 Increased activity of AMP deaminase by decreased interaction with PGM1 and depletion of F1,6P: a 1 1 1novel mechanism of diabetic cardiomyopathy. Yuki Tatekoshi , Masaya Tanno , Hidemichi Kouzu , Atsushi

2 1 1 1 1 1 1Kuno , Satoko Ishikawa , Toshiyuki Yano , Wataru Ohwada , Kei Nakata , Keitaro Nishizawa , Takayuki Miki , 1 1Tetsuji Miura , Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University,

2Sapporo, Japan, Department of Pharmacology, Sapporo Medical University, Sapporo, Japan

WE-010 Angiogenesis in patients with angiographically significant coronary artery diseases and chronic heart 1,2failure: endothelial progenitor cells, growth factors and cytokines. Karina Khmelnitskaya , Eugenii

1,2 1 2Shlyakhto , First Pavlov State Medical University, Saint-Petersburg, Russia, Almazov Federal Medical Reseach Centre, Saint-Petersburg, Russia

WE-011 Effects of phosphodiesterase-5 A (PDE5A) inhibition on the hypertrophied myocardium of 1 1spontaneously hypertensive rats (SHR). Daiana Sabrina Escudero , Romina Gisel Díaz , Maria Soledad

1 2 1 1Brea , Enrique Leo Portiansky , Néstor Gustavo Pérez , Centro de Investigaciones Cardiovasculares Dr. H.E. 2Cingolani, La Plata, Buenos Aires, Argentina, Laboratorio de Análisis de Imágenes del Instituto de Patología,

La Plata, Argentina2+WE-012 Cardiomyocyte high Ca operational levels linked with arrhythmogenic vulnerability in a rat model of

1 1 1hypertrophic heart failure with preserved ejection fraction. James Bell , Claire Curl , Antonia Raaijmakers , 1 1 1 2,1 1 1Wendy Ip , Chanchal Chandramouli , Tristan Harding , Kimberley Mellor , Stephen Harrap , Lea Delbridge ,

1 2University of Melbourne, Melbourne, Australia, University of Auckland, Auckland, New Zealand



WE-013 Alda-1 improves cardiac function in the heart failure mice carrying human aldehyde dehydrogenase 2 1 1 1 2 2E487K variant. Vanessa Lima , Ivson Silva , Cintia Ueta , Rafael Dariolli , Leonardo Jensen , José Eduardo

2 2 1 1Krieger , Maria Cláudia Irigoyen , Julio Ferreira , Institute of biomedical science, University of Sao Paulo, Sao 2Paulo, SP, Brazil, Heart Institute, University of Sao Paulo, Sao Paulo, SP, Brazil

WE-014 Arterial hypertension due to adrenal pheochromocytoma: modern methods of diagnosis and 1 1 1 1treatment. Ramiz Abdulgasanov , Sanchez Sebastian , Alexey Ivanov , Mehriban Abdulgasanova , Aslan

1 1Ordokov , Scientific center of cardiovascular surgery named after A. N. Bakulev, Moscow, Russia

WE-015 Arterial hypertension due to primary hyperaldosteronism: modern methods of diagnosis and 1 1 1 1treatment. Ramiz Abdulgasanov , Alexey Ivanov , Sanchez Sebastian , Mehriban Abdulgasanova , Aslan

1 1Ordokov , Scientific center of cardiovascular surgery named after A. N. Bakulev, Moscow, Russia

WE-017 Arterial hypertension due to renal parenchymal lesions (diagnosis and treatment). Ramiz 1 1 1 1 1 1Abdulgasanov , Sanchez Sebastian , Alexey Ivanov , Mehriban Abdulgasanova , Aslan Ordokov , Scientific

center of cardiovascular surgery named after A. N. Bakulev, Moscow, Russia

WE-018 Cardiac anti-fibrotic effects of direct AT2 and Mas receptor stimulation in stroke-prone spontaneously 1 1hypertensive rats. Dhaniel Baraldi , Monash University, Melbourne, Victoria, Australia

WE-019 A simplified, Langendorff-free method for concomitant isolation of viable cardiac myocytes and 1,2 2 1,2 1fibroblasts from the adult mouse heart. Matthew Ackers-Johnson , Peter Li , Roger Foo , Genome

2Institute of Singapore, Singapore, Singapore, National University of Singapore, Singapore, Singapore

WE-020 Study of a possible paracrine communication between cardiac fibroblasts and myocytes induced by 1,3 1,3 1,3 1,3 1,3Galectin-3. Mario Bustamante , Ingrid Oyarún , Georthan Mancilla , Clara Quiroga , Hugo E. Verdejo , Sergio

2,3 1,3 1Lavandero , Pablo Castro , Lab. de Señalización Cardiovascular, División de Enfermedades Cardiovasculares, 2Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile, Lab. de Transducción de Señales

3Moleculares, Facultad de Cs. Químicas y Farmacéuticas, Universidad de Chile, Santiago, Chile, Advanced Center for Chronic Diseases (ACCDiS), Universidad de Chile & Pontificia Universidad Católica de Chile, Santiago, Chile

1,2WE-021 Identification of emerging micro-RNA markers for heart failure development. Geortan Mancilla , Ingrid 1,2 2 2 2 1,2 1,2Oyarzún , Rocio Artigas , Ignacio Wichmann , Alejandro Corvalan , Clara Quiroga , Hugo Verdejo , Pablo

1,2 1Castro , Lab. de Señalización Cardiovascular, División de Enfermedades Cardiovasculares, Facultad de 2Medicina, PUC, Santiago, Chile, Advanced Center for Chronic Diseases (ACCDiS), Universidad de Chile &

Pontificia Universidad Católica de Chile, Santiago, Chile., Santiago, Chile1WE-022 Role of Carbonic Anhydrase IX and Hypoxia-Inducible Factor 1 in infarcted rat heart. Mariela Nolly ,

1 1 1 1Andrés Pinilla , Juliana Fantinelli , Patricio Morgan , Centro de Investigaciones Cardiovasculares Dr. H.E. Cingolani, La Plata, Buenos Aires, Argentina

1WE-023 The cMyBP-C E258K HCM-causing mutation does not affect mRNA splicing. Willem De Lange , Nicole 1 1 1 1Bednarz , Richard Moss , Carter Ralphe , University of Wisconsin, Madison, Wisconsin, USA

1 1WE-024 Neuregulin-1 modulates doxorubicin cardiotoxicity in mouse. Marina Bonanno , Abigail Perez Abraham , 1 1 1 1Agustín Rizzo , Hernán García Rivello , Cecilia M. Hertig , INGEBI, Buenos Aires, Argentina

1WE-025 2-deoxy-ATP enhances multiple kinetic parameters to improve cardiac function. Ivan Tomasic , Marcus 1 1 1 1 1 1Henze , Ferdinand Evangelista , Anu Anto , Hector Rodriguez , Sadie Bartholomew Ingle , MyoKardia, Inc.,

South San Francisco, CA, USA

Ischemia/Reperfusion Injury

WE-026 Frailty, not age, predicts age-dependent cardiac contractile dysfunction under basal and ischemic 1 2conditions in Langendorff-perfused hearts from C57BL/6J mice. Hirad Feridooni , Arash Boroumandi ,

3 1 2 1 1 Nazari Polidovitch , Robert Rose , Robert Tsushima , Susan Howlett , Dalhousie University, Halifax, Canada,2 3York University, Toronto, Canada, University of Toronto, Toronto, Canada

WE-027 RIP3 Mediates ischemia- and oxidative stress-induced myocardial necroptosis via CaMKII/mPTP 1 1 1,2 1signalling pathway. Yan Zhang , Ting Zhang , Rui-Ping Xiao , Institute of Molecular Medicine, Peking

University; State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University, Beijing, 2China, Peking-Tsinghua Center for Life Sciences, Peking University;Beijing City Key Laboratory of

Cardiometabolic Molecular Medicine, Peking University, Beijing, China

WE-028 Cardiac-protection of acetylcholine on ischemia/reperfusion injury via regulation of TNF-α/TNFR1/2 1 1 1 1 1signal pathway. Dong-Ling Li , Jin-Jun Liu , Xiao-Jiang Yu , Wei-Jin Zang , Department of Pharmacology,

Health Science Center, Xi'an Jiaotong University, Xi'an city, Shaanxi Province, China

WE-029 Acute hyperglycemia abolishes cardioprotection by remote ischemic preconditioning. Tamás 1 1 1 1 1 1Baranyai , Csilla Terézia Nagy , Gábor Koncsos , Zsófia Onódi , András Makkos , Zoltán V. Varga , Péter

1,2 1,2 1Ferdinandy , Zoltán Giricz , Department of Pharmacology and Pharmacotherapy, Semmelweis University, 2Budapest, Hungary, Pharmahungary Group, Szeged, Hungary

WE-030 LAPTM4b protects hearts from ischemia/reperfusion injury by promoting autophagy flux. Shan-Shan 1 1 1 1 1 1 1 1Gu , Jin-Long Liu , Ji-Liang Tan , Yan-Jun Zheng , Xu-Xia Li , Qiang Li , Huang-Tian Yang , Institute of Health

Sciences, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine, Shanghai, China

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46

WE-031 The role of calcium-sensing receptors and spermine in hypoxia-induced pulmonary vascular 1 1 1 1 1remodeling and the mechanism. Can Wei , Xue Peng , Guangwei Li , Changqing Xu , Harbin Medical

University, Harbin, China

WE-032 Exogenous H S contributes to recovery of ischemic post-conditioning-induced cardioprotection in 21 1 1the aging rat and cardiomyocytes and the related mechanism. Hongzhu Li , Weiming Sun , Lina Li ,

1 1Changqing Xu , Harbin Medical University, Harbin, China

WE-033 Cardiomyocyte-specific Runx1 deficiency protects the heart from ischemia-reperfusion injury in vivo. Ashley 1 1 1 1 1 2Cochrane , Weihong He , Charlotte McCarroll , Peter Bowman , Stuart Nicklin , Ewan Cameron , Christopher

1 1Loughrey , Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of 2Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK, School of Veterinary Medicine, College

of Medical, Veterinary and Life Sciences, University of Glasgow, Garscube Campus, Bearsden Road, Glasgow, UK

WE-034 Simultaneous ultrasound diagnosis and treatment of thrombosis using activated platelet targeted 1,2 1 1theranostic microbubbles. Xiaowei Wang , Yannik Gkanatsas , Jathushan Palasubramaniam , Jan David

1 2 1,2 1Hohmann , Christoph Hagemeyer , Karlheinz Peter , Baker IDI Heart and Diabetes Institute, Melbourne, 2Australia, Monash University, Melbourne, Australia

WE-035 Acetylcholine to improve calcium dyshomeostasis in cardiovascular disease: attenuated er-pm 1 1 1 1 1 1 1 1contacts. Ming Zhao , Long-Zhu Liu , Yi Lu , Xi He , Hang-Huan Jia , Xiao-jiang Yu , Man Xu , Dong-Ling Li ,

1 1Wei-jin Zang , Department of Pharmacology, Xi'an Jiaotong University Health Science Center, Xi'an, China

WE-036 Dopamine D2 receptors is iinvolved in the cardioprotection of ischemic post-conditioning in rat by 1 1 1 1 1activating autophagy. Can Wei , Hong Li , Hongzhu Li , Changqing Xu , Harbin Medical University, Harbin, China

WE-037 Extracellular RNA induces ischemia/reperfusion injury by Tumor Necrosis Factor (TNF-α) – Shedding: 1,2 3 4The role of TNF-receptor 1. Hector Cabrera-Fuentes , Sandrine Lecour , Marisol Ruiz-Meana , David Garcia-

4 5 2 1 1Dorado , Klaus Schlüter , Derek Hausenloy , Klaus Preissner , Institute of Biochemistry, Medical School, Justus- 2Liebig-University, Giessen, Germany, Cardiovascular & Metabolic Diseases Program, Duke-NUS Graduate

3Medical School, Singapore, Singapore, Hatter Institute for Cardiovascular Research, University of Cape Town, 4Cape Town, South Africa, Hospital Universitari Vall d´Hebron, Laboratorio de Cardiología Experimental,

5Barcelona, Spain, Institute of Physiology, Medical School, Justus-Liebig-University, Giessen, Germany

WE-038 Endogenous annexin-A1 is cardioprotective against myocardial infarction in mice in vivo. Cheng Xue 1,2 1,3 1 3 1 1Qin , Siobhan B Finlayson , Sarah Rosli , Colleen J Thomas , Annas AI-Sharea , Andrew Murphy , Helen

1 4 4 1 1 1,2 1Kiriazis , Yuan H Yang , Eric F Morand , Xiao-Jun Du , Xiaoming Gao , Rebecca H Ritchie , Baker IDI Heart 2and Diabetes Institute, Melbourne, Australia, Department of Pharmacology, University of Melbourne,

3 4Melbourne, Australia, La Trobe University, Bundoora, Australia, Centre for Inflammatory Diseases, Monash University, Clayton, Australia

WE-039 HAX-1 regulates contractile recovery after ischemia/reperfusion injury by preventing SERCA2a 1 1 1 1 1degradation. Philip Bidwell , Guan-Sheng Liu , Chi Keung Lam , Jack Rubinstein , Evangelia Kranias ,

1University of Cincinnati, Cincinnati, OH, USA1WE-040 Adenosine A receptor biased agonism in cardiac ischemia-reperfusion injury. Jo-Anne Baltos , Chung 1

1 1 1 1 1 1 1Chuo , Andrew Kompa , Manuela Jorg , Henry Krum , Arthur Christopoulos , Peter Scammells , Paul White , 1 1Lauren May , Monash University, Melbourne, Victoria, Australia

1WE-041 Deletion of the NADPH oxidase organizing protein NoxO1 promotes angiogenesis. Katrin Schröder , 1 1 1 1 1 1Sabine Harenkamp , Jeremy Epah , Christoph Schürmann , Juri Vogel , Beliza Rashid , Flavia Rezende , Ralf

1 1P. Brandes , Goethe University, Frankfurt am Main, Germany

WE-042 Cardioprotective reperfusion strategies improve cardiac recovery after global, warm ischemia in an 1 1isolated working rat heart model of donation after circulatory death. Emilie Farine , Petra Niederberger ,

1 1 1 1 1 1Rahel Wyss , Natalia Méndez Carmona , Thierry Carrel , Hendrik Tevaearai Stahel , Sarah Longnus , Clinic of Cardiovascular Surgery, Inselspital, Bern University Hospital, University of Bern, Berne, Switzerland

WE-043 High circulating fatty acids prior to warm ischemia decrease cardiac recovery in an isolated rat heart 1 1 1 1model of donation after circulatory death. Petra Niederberger , Emilie Farine , Maria Arnold , Rahel Wyss ,

1 1 1 1 1Natalia Méndez Carmona , Thierry Carrel , Hendrik Tevaearai Stahel , Sarah Longnus , Clinic of Cardiovascular Surgery, Inselspital, Bern University Hospital, University of Bern, CH-3010 Bern, Switzerland

WE-044 T185-Study and characterization of p38MAPK's key residue involved in Ischaemic Heart Disease. 1 1 1 1 1Dibesh Thapa , Denise Eva Martin , Gian De Nicola , Michael Marber , Kings College London, London, UK

WE-045 The inhibition of proteasomes prevents Mitofusin 2 and Miro 1 degradation in cardiomyocytes during 1 1 1 1,2 1ischemia –reperfusion. Ivonne Olmedo , Gonzalo Pino , Cecilia Anríquez , Zully Pedrozo , Paulina Donoso ,

1 1Gina Sánchez , Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, 2Chile, Advanced Center for Chronic Diseases, Facultad de Medicina, Universidad de Chile, Santiago, Chile

WE-046 The new St Thomas' Hospital polarized cardioplegia shows non-inferiority and improved efficacy of myocardial protection in pigs undergoing cardiopulmonary bypass compared to St. Thomas' 2

1 1 1 1 1 1cardioplegia. Felix Nagel , David Santer , Anne Kramer , Attila Kiss , Wolfgang Dietl , Karola Trescher , Klaus 3 2 4 4 1 1Aumayr , Seth Hallström , Hazem Fallouh , David J Chambers , Bruno K Podesser , Ludwig Boltzmann

Cluster for Cardiovascular Research, Department for Biomedical Research, Medical University of Vienna, 2Vienna, Austria, Institute of Physiological Chemistry, Center for Physiological Medicine, Medical University of



3 Graz, Graz, Austria, Clinical Institute for Pathology, AKH Wien, Medical University of Vienna, Vienna, Austria,4Cardiac Surgical Research, The Rayne Institute (King's College London), Guy's and St Thomas' NHS Foundation Trust, St Thomas' Hospital, London, UK

WE-047 Quantitative assay of microvascular hyper-permeability following cardiac ischemia-reperfusion. Li-1,2 2 2 2 2 1Ping Han , Xiao-Ming Gao , Xiao-Lei Mao , Yi-Dan Su , Xiao-Jun Du , Wenzhou Medical College, Wenzhou,

2Zhejiang, China, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia

WE-048 Effects of hydrogen sulphide (H S) on oxidative stress in acute myocardial ischemia injury in isolated 21 1 1 1 1 1hearts in rats. Zhang Jianxin , Liu Fang , Li Lanfang , Zhang Qinzeng , Xie Lijun , Hebei Academy of Medical

Sciences,Shijiazhuang, Hebei,, China

WE-049 Effects of Simvastatin on the expression of P47phox in renal ischemia reperfusion injury. Xiao-hong 1 1 1 1 1 1Xia , Jiao Jing , Li-jing Niu , Yan-ling Wang , Zhi-hui Zhi-hui Miao , Hebei Academy of Medical Sciences,

Shijiazhuang, China

Contractility & Mechanics

WE-061 A pathogenic MYBPC3 25-bp polymorphic variant causes hypertrophic cardiomyopathy in South 0 1Asian descendants. Sakthivel Sadayappan , Loyola University Chicago, Maywood, IL 60153, USA

WE-062 Lack of essential myosin light chain phosphorylation impairs cardiac ability to adapt to augmented 1 2 2 1 1physical demand. Selina Hein , Lisa Scheid , Matias Mosqueira , Mandy Kossack , Benjamin Meder , Rainer

2 1 1 2Fink , David Hassel , Heidelberg University Hospital, Heidelberg, Germany, Heidelberg University, Heidelberg, Germany

WE-063 CYP2C19 and PON1 genetic variants as potential predictors for the risk of bleeding in antiplatelet-1 2 2 2 3 3treated patients. Yu Zhang , Mengzhen Zhang , Zhoucuo Qi , Qiuxiong Lin , Bin Zhang , Jiyan Chen , Shilong

2,3 1Zhong , School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, Guangdong, 2 3China, Medical Research Center, Guangdong General Hospital, Guangzhou, Guangdong, China, Guangdong

Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China1WE-064 ADP-stimulated contraction: a predictor of thin-filament activation in cardiac disease. Vasco Sequeira , Aref

1 1 2 3 1 1 1Najafi , Paul J.M. Wijnker , Cris dos Remedios , Michelle Michels , Diederik W.D. Kuster , Jolanda van der Velden , VU 2University Medical Center, Amsterdam, The Netherlands, Muscle Research Unit, Bosch Institute, University of Sydney;

3Anderson Stuart Building (F13), Sydney, Australia, Cardiology, Erasmus Medical Center, Rotterda,, The Netherlands

WE-065 Cross-bridge dynamics is determined by two velocity dependent kinetics; implications on the adaptive 1 2 1 1and synchronous cardiac function. Daria Amiad Pavlov , Michal Horowitz , Amir Landesberg , Faculty of

2Biomedical Engineering, Technion IIT, Haifia, Israel, Faculty of medicine, the Hebrew University, Jerusalem, Israel

WE-066 The functional association between the sodium/bicarbonate cotransporter and the soluble adenilate 1 1cyclase (sAC) modulates basal cardiac contractility. María Sofía Espejo , María Carolina Ciancio ,

1 1 1 1Alejandro Orlowski , Ernesto Alejandro Aiello , Verónica Celeste De Giusti , Centro de Investigaciones Cardiovasculares Dr. H.E. Cingolani, La Plata, Buenos Aires, Argentina

WE-067 Proteomic analysis of excitation-contraction coupling abnormalities in a rat model of heart failure with preserved 1 1 1 1 1 1ejection fraction. Daniel Soetkamp , Romain Gallet , Ronald Holewinski , Vidya Venkatraman , Xin Yue , Rui Zhang ,

1 1 1 1Eduardo Marbán , Joshua I. Goldhaber , Jennifer E. Van Eyk , Cedars-Sinai Medical Center, Los Angeles, CA, USA

WE-068 Insulin treatment did not prevent cardiac and baroreflex dysfunctions in a model of type 1 diabetes. 1 3 2Sarah Cristina Ferreira Freitas , Iris Callado Sanches , Jacqueline Freire Machi , Paulo Magno Martins

2 2 1 1 2Dourado , Maria Claudia Irigoyen , Kátia De Angelis , Universidade Nove de Julho, São Paulo, Brazil, Heart 3Institute Hospital, São Paulo, Brazil, São Judas Tadeu University, São Paulo, Brazil

1WE-069 Nitric oxide and CaMKII: critical steps in the inotropic response to IGF-1. Juan Ignacio Burgos , Alejandra 1 1 1 1Yeves , Irene Ennis , Martín Vila Petroff , Centro de Investigaciones Cardiovasculares Dr. H.E. Cingolani, La

Plata, Buenos Aires, Argentina

WE-070 oxiCaMKII-dependent RyR2 phosphorylation mediates contractile dysfunction associated with 1 1 1 2 2sepsis. Marisa Sepúlveda , Luis Gonano , Manuel Viotti , Micaela López Alarcón , Isalira Ramos , Adriana

2 2 1 1Bastos Carvalho , Emiliano Medei , Martín Vila Petroff , Centro de Investigaciones Cardiovasculares Dr. H.E. 2Cingolani, La Plata, Buenos Aires, Argentina, Universidade Federal do Rio de Janeiro Centro de Ciencias da

Saúde Instituto de Biofisica Carlos Chagas Filho, Rio de Janeiro, Brazil

WE-071 Silencing of the epidermal growth factor receptor (EGFR) blunts the slow force response to 1 1 1myocardial stretch. María Soledad Brea , Romina Gisel Díaz , Patricio Eduardo Morgan , Claudia Irma

1 1 1Caldiz , Néstor Gustavo Pérez , Centro de Investigaciones Cardiovasculares Dr. H.E. Cingolani, La Plata, Buenos Aires, Argentina

WE-072 Thioredoxin 1 (TRX1) overexpression cancels the slow force response (SFR) development. Maite R 1 1 2 2 1 1 1Zavala , Romina G Diaz , Martin Donato , Ricardo J Gelpi , María C Villa-Abrille , Néstor G Pérez , Centro de

2Investigaciones Cardiovasculares Dr. H.E. Cingolani, La Plata, Buenos Aires, Argentina, Instituto de Fisiopatología Cardiovascular, Universidad de Buenos Aires, Buenos Aires, Argentina

WE-073 Dynamic resistance exercise training induces skeletal muscle and cardiac hypertrophy and improves

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48

1 2,1 1baroreflex sensitivity in female hypertensive rats. Amanda Araujo , Nathalia Bernardes , Danielle Dias , 1 2 1 1Tafne Mello , Maria Claudia Irigoyen , Kátia De Angelis , Laboratory of Translational Physiology, Universidade

2Nove de Julho (UNINOVE), Sao Paulo, SP, Brazil, Hypertension Unit, Heart Institute (InCor), School of Medicine, University of Sao Paulo, Sao Paulo, SP, Brazil

1WE-074 Effect of aging on heart function and calcium handling: impact of NOX inhibition. Alvaro Valdes , 1 1 1 1Guillermo Barrios , Nikol Ponce , Daniel Gonzalez , Universidad de Talca, Talca, Chile

WE-075 Mechanisms of sex-difference in serotonergic and α -adrenergic vasoconstriction in the internal 11mammary artery of patients going through coronary artery bypass graft. Victor Lamin , Amenah

1 2 2 2 2 1Jaghoori , Michael Worthington , James Edwards , Fabiano Viana , Robert Stuklis , David Wilson , John 1 1 Beltrame , School of Medicine, The University of Adelaide, Adelaide, South Australia, Australia,

2Cardiothoracic Surgical Unit, The Royal Adelaide Hospital, Adelaide, South Australia, Australia

WE-076 The Effects of sildenafil, Phosphodiesterase 5 inhibitor, on the expression of α and β myosin heavy 1 2chains in hypoxia induced right ventricular hypertrophy in mice. Said Khatib , Mukhallad Al-Jinabi ,

2 2 1 Nayaf Gharaibeh , Anwar Alkhayat , Faculty of Medicine, King Fahad Medical City, Riyadh, Saudi Arabia,2Faculty of Medicine. Jordan University of Science and Technology, Irbid, Jordan

WE-077 Bisphenol S depresses myocardial function through an estrogen receptor-β-dependent cascade. 1 1 1Melissa Ferguson , W. Glen Pyle , Centre for Cardiovascular Investigations, Department of Biomedical

Sciences, University of Guelph, Guelph, Ontario, Canada

EC Coupling

WE-078 Sarcoplasmic reticulum (SR) calcium transport in atrial myocytes isolated from healthy human hearts. Jair 1 2 2 2Trapé Goulart , Orlando Petrucci , Karlos Alexandre de Souza Vilarinho , Felipe Augusto da Silva Souza , Pedro

2 2 1,3Paulo Martins de Oliveira , Lindemberg Mota Silveira-Filho , José Wilson Magalhães Bassani , Rosana Almada 3 1Bassani , Department of Biomedical Engineering, School of Electrical and Computer Engineering, University of

2Campinas, Campinas, SP, Brazil, Department of Surgery, Faculty of Medical Sciences, University of Campinas, 3Campinas, SP, Brazil, Center for Biomedical Engineering, University of Campinas, Campinas, SP, Brazil

WE-079 Endothelial ATP-binding cassette G1 in mouse endothelium protects against hemodynamic-induced 1 2 1 2 1 1,2 1atherosclerosis. Jinlong He , Jiaxing Wang , Xu Zhang , Wei Pang , Ding Ai , Yi Zhu , Tianjin Medical

2University, Tianjin, China, Peking University Health Science Center, Beijing, China

WE-080 High-throughput screens to discover inhibitors of leaky ryanodine receptor calcium channels. Robyn 1 1 1 1 1 1 1Rebbeck , Maram Essawy , Florentin Nitu , David Thomas , Donald Bers , Razvan Cornea , University of

2Minnesota, Minneapolis, Mn, USA, University of California, Davis, California, USA2+WE-081 Functional crosstalk of RyR2 and InsP R2 mediated SR-Ca release in atrial cardiomyocytes. Marcel 3

1 1 1Wullschleger , Marcel Egger , Physiology, UniBE, Bern, Switzerland

WE-082 Influence of ACE inhibitors on frailty and cardiac function in middle-aged female C57BL/6 mice. Kaitlyn 1 1 1Keller , Susan Howlett , Dalhousie University, Halifax, Nova Scotia, Canada

WE-083 Chronic testosterone withdrawal modifies cardiac contraction and calcium homeostasis in 1 1ventricular myocytes isolated from gonadectomised C57BL/6 male mice. Omar Ayaz , Robert Rose ,

1 1Susan Howlett , Dalhousie University, Halifax, Canada

WE-084 Force-frequency relationship in rat ventricular myocytes; elucidating the intracellular mechanisms. 1 1 1 1 1 1Verónica De Giusti , Ignacio Aiello , María Sofía Espejo , María Carolina Ciancio , Ernesto Alejandro Aiello , Centro

de Investigaciones Cardiovasculares Dr. H.E. Cingolani, La Plata, Buenos Aires, Argentina

WE-085 RyR2 haploinsufficiency in a rabbit model is compensated by fine-tuning channel activity. Francisco J. 1 1 1 1 1Alvarado , Jonathan Hernandez , Y. Eugene Chen , Hector H. Valdivia , University of Michigan, Ann Arbor, MI, USA

Electrophysiology/Arrhythmias

WE-086 Thyroid stimulating hormone can directly modulates the cardiac electrical activity. Julieta Fernandez 1 2 2 3 1,2Ruocco , Hiart Alonso , Gallego Monica , Layse Malagueta Vieira , Ainhoa Rodriguez De Yurre , Oscar

2 1 1Casis , Emiliano Medei , Carlos Chagas Filho Biophysical Institute, Federal University of Rio de Janeiro 2(UFRJ), Rio de Janeiro/ Rio de Janeiro, Brazil, Departament of Physiology, Pais Vasco University (UPV/EHU),

3Pais Vasco, Spain, Department of Biophysics and Radiobiology, Federal University of Pernambuco, Recife, Brazil

1 1WE-087 miR-19b deficiency impairs cardiac repolarization in zebrafish. Alexander Benz , Dominik Auth , Claudia 1 1 1 1 1Seyler , Edgar Zitron , Hugo A. Katus , David Hassel , Department of Medicine III, Cardiology, Heidelberg

University Hospital, Heidelberg, Germany

WE-088 Early intravenous low/high doses of Metoprolol in myocardial infarction dogs on the effects of cardiac 1 1 1sympathetic activities and electrophysiological properties . Danning Wang , Dening Liao , Department

of Cardiology Changzheng Hospital Second Military Medical University, Shanghai, China2+ +WE-089 Inhibition of small conductance Ca -activated K -channels converts and prevents reinduction of atrial



POSTER SESSIONS

1,2 2fibrillation in pigs where vernakalant fails. Jonas Goldin Diness , Lasse Skibsbye , Jesper Hastrup 3 1,2 4 1 2Svendsen , Tobias Speerschneider , Nils Edvardsson , Ulrik Svane Soerensen , Thomas Jespersen , Morten

1,2 1,2 1 2Grunnet , Bo Hjorth Bentzen , Acesion Pharma, Copenhagen, Denmark, The Danish National Research 3Foundation Centre for Cardiac Arrhythmia, University of Copenhagen, Copenhagen, Denmark, The Danish

National Research Foundation Centre for Cardiac Arrhythmia, The Heart Centre, Rigshospitalet, 4Copenhagen, Denmark, Sahlgrenska Academy at Sahlgrenska University Hospital, Gothenburg, Sweden

WE-090 Comparing R CHADS and CHA DS VASC scores in stroke patients with non-valvular atrial fibrillation 2 2 2 21 1 1 1 1and renal failure. Mohinder Reddy Vindhyal , Shravani Vindhyal , Travis Haneke , Paul Ndunda , Freidy Eid ,

1 1Kenneth J Kallail , KU School Of Medicine - Wichita, Wichita, Kansas, USA

WE-091 Characterization of catecholaminergic polymorphic ventricular tachycardia using patient-specific human induced pluripotent stem cells and a transgenic mouse model harboring the mutation H2464D in

1,2 1 1 1the cardiac ryanodine receptor. Jonathan J. Hernández , Yanting Zhao , Carmen Valdivia , Todd Herron , 2 3 2,3 1 1 1Jianhua Zhang , Kathleen R. Maginot , Timothy J. Kamp , José Jalife , Héctor H. Valdivia , Center for Arrhythmia

2Research, University of Michigan, Ann Arbor, Michigan, USA, University of Wisconsin-Madison, Madison, 3Wisconsin, USA, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA

WE-092 Refractoriness in human atria: Time and voltage dependence of sodium channel availability. Lasse 1 1 2 3 3,4 1Skibsbye , Thomas Jespersen , Torsten Christ , Mary M Maleckar , Jussi T Koivumäki , Department of

Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2Copenhagen, Denmark, Department of Experimental Pharmacology and Toxicology, University Medical

3Center Hamburg-Eppendorf, Hamburg, Germany, Center for Cardiological Innovation and Center for 4Biomedical Computing, Simula Research Laboratory, Oslo, Norway, Department of Biotechnology and

Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, Kuopio, Finland++WE-093 Carvedilol and its non-ß-blocking analog VK-II-86 prevent digitalis-induced Ca waves in cardiac

1 1 1 2 2myocytes. Luis A Gonano , Marisa Sepúlveda , Tamara Tottef , Tom G Backs , S.R Wayne Chen , Alicia 1 1 1Mattiazzi , Martín Vila Petroff , Centro de Investigaciones Cardiovasculares Dr. H.E. Cingolani, La Plata, Buenos

2Aires, Argentina, University of Calgary, Alberta, Canada

WE-094 Internal pacemaker cell mechanisms mediating autonomic nervous regulation of the heart rate. 1 1 1Joachim Behar , Yael Yaniv , Technion, Haifa, Israel

WE-095 An implanted dual-site pacing device mimics pacing-induced dyssynchrony and cardiac 1 1 1resynchronization therapy in freely moving rats. Wesam Mulla , Sabina Sapunar , Sigal Elyagon , Hovav

1 1 1 1 1Gabay , Janet Ozer , Noah Liel-Cohen , Yoram Etzion , Ben-Gurion University, Beer-Sheva, Israel

WE-096 Human calmodulin mutation associated with idiopathic ventricular fibrillation causes CaMKII-1 1 1dependent RyR2 activation. Nieves Gomez-Hurtado , Hyun S Hwang , Christopher N Johnson , Walter J

1 2 1 1 2Chazin , Derek Laver , Bjorn C Knollmann , Vanderbilt University, Nashville, TN, USA, University of Newcastle, Callaghan NSW, Australia

1WE-097 Prevailing action potential duration determines the electrical restitution curve. James Winter , Yang 2 1 2 1 1 Hsiang-Yu , Angela W.C. Lee , Ken T MacCleod , Michael J Shattock , King's College London, London, UK,

2Imperial College London, London, UK

WE-098 Effective treatment of atrial fibrillation in isolated guinea pig hearts by combining established anti-2+ + 1arrhythmics and small conductance Ca activated (SK) K channel block. Jeppe Kirchhoff , Jonas G

2 1 2 1 1Diness , Majid Sheykhzade , Morten Grunnet , Thomas Jespersen , University of Copenhagen, Copenhagen, 2Denmark, Acesion Pharma, Copenhagen, Denmark

WE-099 Unnatural Amino Acid Photo-Crosslinking of the I Channel Complex Demonstrates a KCNE1:KCNQ1 Ks1 1 1 1Stoichiometry of up to 4:4. Christopher Murray , Maartje Westhoff , Emely Thompson , Robert Emes ,

1 1 1Jodene Eldstrom , David Fedida , University of British Columbia, Vancouver, Canada

Mitochondria

+ -WE-100 Role of the NBCn1 Na /HCO co-transporter in mitochondria of hypertrophic hearts, Fernanda Carrizo 31 1 1 1Velásquez , Lorena Vargas , Bernardo Alvarez , Centro de Investigaciones Cardiovasculares Dr. H.E. Cingolani, La

Plata, Buenos Aires, Argentina

WE-101 Decreased complex I dependent respiration and increased restriction for ADP in volume overload-induced 1 1 1 1 1 1atrial dilatation. Kalju Paju , Taavi Põdramägi , Nadežda Peet , Margus Eimre , Lumme Kadaja , Mart Roosimaa ,

1 1 1 1Andres Piirsoo , Enn Seppet , Arno Ruusalepp , University of Tartu, Tartu, Estonia

WE-102 The effect of chronic continuous hypoxia on enzyme activities and membrane permeability of rat heart 1 2 2 2 1mitochondria. Martin Kalous , Zdenek Drahota , Anna Chytilova , Jan Neckar , Faculty of Sciences, Charles

2University, Prague, Czech Republic, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic

1WE-103 Mice lacking the mitochondrial calcium uniporter have alterations in F F -ATP synthase. Randi Parks , Sara 1 01 2 3 1 1Menazza , Angel Aponte , Toren Finkel , Elizabeth Murphy , Systems Biology Center, NHLBI, NIH, Bethesda, MD,

2 3USA, Proteomic Core Facility, Bethesda, MD, USA, Center for Molecular Medicine, Bethesda, MD, USA

50

WE-104 Blocking cell surface nucleolin in heart cells prevents uptake of immunogenic DNA. Lars Henrik 1 1 1 1 1 2 1Mariero , Anton Baysa , Yuchuan Li , May-Kristin Torp , Guro Valen , Jarle Vaage , Kåre-Olav Stensløkken ,

1 2University of Oslo, Oslo, Norway, Oslo University Hospital, Oslo, Norway

WE-105 Increased calpain-1 in cardiomyocyte mitochondria disrupts ATP synthase and promotes reactive oxygen 1 1,2 1,2 1species generation to induce dilated heart failure in mice. Ting Cao , Dong Zheng , Rui Ni , Lulu Zhang ,

1,2 1 2Tianqing Peng , Soochow University, Suzhou, China, Lawson Health Research Institute, London, Ontario, Canada

THURSDAY, April 21, 1:00-3:00 PMHeart Failure & Hypertrophy

TH-001 Changes in cardiac adenosine A3 receptor function and expression associated with essential 1 1 1 1hypertension. Roselyn Rose'Meyer , Leanne Low , Ming-Fen Ho , Griffith University, Southport,

Queensland, Australia

TH-002 Physiological and pathological left ventricular hypertrophy of comparable degree is associated with characteristic differences of in vivo hemodynamics associated with distinct expression of

1 1 1 1 1mitochondrial regulators. Attila Oláh , Balázs Tamás Németh , Csaba Mátyás , László Hidi , Árpád Lux , 1 1 1 1 1 1Mihály Ruppert , Dalma Kellermayer , Alex Ali Sayour , Lilla Szabó , Marianna Török , Anna Meltzer , Béla

1 1 1Merkely , Tamás Radovits , Heart and Vascular Center, Semmelweis University, Budapest, Hungary

TH-003 Differential expression of plasmalogen lipids following modulation via dietary supplementation in a mouse 1,2 1 1,2 1model of reduced PI3K activity. Yow Keat Tham , Natalie A. Mellett , Peter J. Meikle , Julie R. McMullen ,

1 2Baker IDI Heart and Diabetes Institute, Melbourne, Australia, Monash University, Melbourne, Australia

TH-004 Proliferative and hypertrophic defects contributes to LMNA associated dilated cardiomyopathy. Kenji 1,2 2 2 2 2 2Onoue , Hiroko Wakimoto , Jiangming Jiang , Michael Parfenov , Danos Christodoulou , Steve DePalma ,

2 2 2 1 2 2David Conner , Joshua Gorham , David McKean , Yoshihiko Saito , Jonathan Seidman , Christine Seidman , 1 2Nara Medical University, Kashihara, Nara, Japan, Harvard Medical School, Boston, MA, USA

2+TH-005 Targeting the L-type Ca channel alters mitochondrial function and attenuates hypertrophic 1 1cardiomyopathy in a Troponin I mutant mouse model. Helena Viola , Victoria Johnstone , Christopher

2,3 1,4 1 2Semsarian , Livia Hool , The University of Western Australia, Western Australia, Australia, Centenary 3Institute, University of Sydney, New South Wales, Australia, Royal Prince Alfred Hospital, New Soth Wales,

4Australia, Victor Chang Cardiac Research Institute, New South Wales, Australia

TH-006 ProteoSeq – a proteotranscriptomics approach to decode alternative isoform expression in cardiac 1 1 1 1 1hypertrophy. Maggie PY Lam , T Umut Dincer , Yi Xing , Peipei Ping , UCLA, Los Angeles, CA, USA

TH-007 Folic acid reduces doxorubicin-induced cardiomyopathy by modulating endothelial nitric oxide 1,2 3 1 2 4synthase. Yanti Octavia , Georgios Kararigas , Martine de Boer , Rinrada Kietadisorn , Melissa Swinnen , Hans

5 5 1 1 1 4 1Duimel , Fons Verheyen , Ihsan Chrifi , Maarten Brandt , Caroline Cheng , Stefan Janssens , Dirk Duncker , An 1,2 1Moens , Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Erasmus MC, University

2Medical Center Rotterdam, Rotterdam, The Netherlands, Department of Cardiology, Cardiovascular Research 3Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands, Institute of Gender in

Medicine and Center for Cardiovascular Research, Charite University Hospital, and DZHK (German Centre for 4Cardiovascular Research) Berlin partner site, Berlin, Germany, Department of Cardiovascular sciences,

5University of Leuven, KU Leuven, Leuven, Belgium, Electron Microscopy Unit, CRISP and Department of Molecular Cell Biology, Maastricht University Medical Center, Maastricht, The Netherlands

TH-008 The cardiopulmonary vascular system and the ventilatory reflex; scientific merits and clinical 1 1 1implications. Anna Faingersh-Klebanov , Amir Landesberg , Technion IIT, Haifa, Israel

1 1TH-009 Heart failure assessment with a multiscale model. Jorge Negroni , Edmundo Cabrera Fischer , Sarah 2 2 1 1 2Kosta , Pierre Dauby , Elena Lascano , Favaloro University, Buenos Aires, Argentina, University of Liege,

Liege, Belgium

TH-010 The specific inhibition of the cardiac electrogenic sodium/bicarbonate cotransporter (NBCe1) leads to 1 1 1cardiac hypertrophy. Romina Di Mattia , María Carolina Ciancio , Ernesto Alejandro Aiello , Alejandro

1 1Orlowski , Centro de Investigaciones Cardiovasculares Dr. H.E. Cingolani, La Plata, Buenos Aires, Argentina1 1TH-011 The rof Profilin-1 in hypertrophic signalling of adult cardiomyocytes. Viola Kooij , Peter O'Gara , Sian

1 1Harding , Imperial College London, London, UK

TH-012 Moderate-intensity physical activity reduces systemic inflammation and maintains cardiorespiratory 1 1function following PM exposure during exercise in rats. Andrew Fenning , Alannah van Waveren , Mitch 2.5

2 1 1 2Duncan , Fiona Coulson , CQUniversity, Rockhampton, Qld, Australia, The University of Newcastle, Newcastle, NSW, Australia

TH-013 Osteopontin Regulates the inflammatory and fibrotic response of transgenic mice expressing cardiac + + 1 1 1specific active Na /H Exchanger isoform 1. Fatima Mraiche , Nabeel Abdulrahman , Iman Abdelaziz , Alain

2 1 2Gadeau , Qatar University, Doha, Qatar, University of Bordeaux, Pessac, France

TH-014 Characterization of the role of inhibitory G protein, adenylyl cyclase isoforms and phosphodiesterases 1,2 1,2to regulate β-adrenoceptor-evoked inotropic responses. Marie Victoire Cosson , Halvard Hiis , Finn



POSTER SESSIONS

1,2 1,2 1Olav Levy , Kurt Allen Krobert , Department of Pharmacology, Institute of Clinical Medicine, University of 2Oslo and Oslo University Hospital, oslo, Norway, K.G. Jebsen Cardiac Research Centre and Center for Heart

Failure Research, Faculty of Medicine, University of Oslo, oslo, Norway1TH-015 Frequency of renal artery lesions in patients with hypertension. Ramiz Abdulgasanov , Sanchez

1 1 1 1 1Sebastian , Alexey Ivanov , Mehriban Abdulgasanova , Aslan Ordokov , Scientific center of cardiovascular surgery named after A. N. Bakulev, Moscow, Russia

1TH-016 Secondary (symptomatic) high blood pressure following aortic lesions. Ramiz Abdulgasanov , Sanchez 1 1 1 1 1Sebastian , Alexey Ivanov , Mehriban Abdulgasanova , Aslan Ordokov , Scientific center of cardiovascular

surgery named after A. N. Bakulev, Moscow, Russia1 3TH-017 Conserved epigenomic basis in mouse and human heart aging. Yuliang Feng , Wei Huang , Joshua S.

4 3 1,2 1 Waxman , Yigang Wang , Xiyong Yu , Guangdong General Hospital, Guangzhou,Guangdong, China,2 3Guangzhou Medical University School of Pharmaceutical Sciences, Guangzhou,Guangdong, China, Dept. of

4Pathology, University of Cincinnati, Cincinnati,Ohio, USA, Division of Molecular Cardiovascular Biology, Cincinnati Children Hospital Medical Center, Cincinnati,Ohio, USA

TH-018 Transferring an in vitro model of pathological cardiac hypertrophy from rat to human engineered heart 1,2 1,2 1,2 1,2 1,2 1,2tissue. Tessa Werner , Marc N Hirt , Kaja Breckwoldt , Ingra Mannhardt , Bärbel Ulmer , Arne Hansen ,

1,2 1Thomas Eschenhagen , Department of Experimental Pharmacology and Toxicology, University Medical 2Center Hamburg-Eppendorf, Hamburg, Germany, DZHK (German Centre for Cardiovascular Research),

partner site Hamburg/Kiel/Lübeck, Hamburg, Germany1TH-019 Tenascin-C promotes fibrosis and impairs cardiac function under pressure overload. Max Kreibich ,

1 1 1 1 1 1 1Elda Dzilic , David Santer , Lorenz Förster , Sandra Trojanek , Dietmar Abraham , Martin Krssak , Attila Kiss , 1 1 1Karola Trescher , Bruno Podesser , Medical University of Vienna, Vienna, Austria

1 1TH-020 Tenascin-C in the murine geriatric heart after myocardial infarction. Felix Nagel , David Santer , Elda 1 1 3 2 1 1 1Dzilic , Maximilian Kreibich , Stefan Stojkovic , Martin Krssak , Karola Trescher , Bruno K Podesser , Ludwig

Boltzmann Cluster for Cardiovascular Research, Department for Biomedical Research, Medical University of 2Vienna, Vienna, Austria, Centre of Excellence High Field MR, Department of Radiology, Medical University of 3Vienna, Vienna, Austria, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria

1 1TH-021 Beta-2 microglobulin contributes to myocardial fibrosis during pressure overload. Hui Gong , Yang Li , 1 1 1 1 1 1Xiaoyi Zhang , Zhidan Chen , Chunjie Yang , Guoping Zhang , Yunzeng Zou , Fudan University, Shanghai, China

TH-022 The Role of Calcium-Sensing Receptor in Human Peripheral T Lymphocytes on the different stages of 1 1 2 1Acute Myocardial Infarction. Yihua Sun , Jingya Zeng , Yong Sun , Department of Clinical Laboratory,The

2Harbin Medical University Tumor Hospital, Harbin, China, Department of Cardiology, The Affiliated Second Hospital of Harbin Medical University, harbin, China

TH-023 Effect and regulation mechanism of exogenous catestatin on blood pressure and cardiac function in 1 1 1 1 1renal hypertensive rats. Xiaofang Fan , Lu Ding , Qingqing Zheng , Xuanying Chen , Xuerui Wang ,

1 1Yongsheng Gong , Institute of Hypoxia Medicine,Wenzhou Medical University, Wenzhou, Zhejiang, China

TH-024 The effect of genes involved in monogenic human cardiomyopathies in a polygenic model of cardiac 1 2 3 4 3hypertrophy. Priscilla Prestes , Francine Marques , Claire Curl , Paul Lewandowski , Lea Delbridge , Stephen

3 1 1 2Harrap , Fadi Charchar , Federation University Australia, Ballarat, Australia, Baker IDI Heart and Diabetes Research 3 4Institute, Melbourne, Australia, University of Melbourne, Melbourne, Australia, Deakin University, Geelong, Australia

TH-025 Assessment of miR-669f in the development of pulmonary arterial hypertension and right ventricular 2 1 1 2hypertrophy. Li Li , Sudhiranjan Gupta , Texas A&M University, Temple, TX, USA, Pekiing University, Beijing, China

Signaling Mechanisms

TH-026 Cardiac apoptosis in the prediabetic heart: CaMKII, Ca mishandling and mitochondria dysfunction. 1 1 2 2 3Federico Marilén , Sommese Leandro , Zanuzzi Carolina , Portiansky Enrique , Dedman John , Kaetzel

3 4 1 1 1Marcia , Wherens Xander , Mattiazzi Alicia , Palomeque Julieta , Centro de Investigaciones 2Cardiovasculares Dr. H.E. Cingolani, La Plata, Buenos Aires, Argentina, Fac. de Cs. Veterinarias; UNLP,

3CONICET-CCT La Plata, La Plata, Buenos Aires, Argentina, Department of Genome Science, University of 4Cincinnati College of Medicine, Cincinnati, OH, USA, Cardiovascular Research Institute, Baylor College of

Medicine, Houston, TX, USA

TH-027 Glycoprotemics reveals decorin fragments with anti-myostatin activity in human atrial fibrillation. Javier 1 2 1 1 1 3Barallobre-Barreiro , Shashi K Gupta , Anna Zoccaratto , Rika Kitazume-Taneike , Mei Chong , Jens W Fischer ,

2 4 5 1 1 1Thomas Thum , Joerg Heineke , Antoine Kichler , Kinya Otsu , Manuel Mayr , King's British Heart Foundation 2Centre, King's College London, London, UK, Institute for Molecular and Translational Therapeutic Strategies, MH-

3Hannover, Hannover, Germany, Institute for Pharmacology and Clinical Pharmacology, Heinrich-Heine-University, 4Düsseldorf, Germany, Experimental Cardiology, Department of Cardiology and Angiology, MH-Hannover,

5Hannover, Germany, Laboratoire Vecteurs: Synthese et Applications Therapeutiques, UMR 7199 CNRS Universite de Strasbourg, Illkirch, France

TH-028 Cardioprotective effect of IGF-1 upon the hypertrophied myocardium of the spontaneously

52

+ +hypertensive rats (SHR): a key role on cardiac Na /H exchanger (NHE-1) activity and oxidative stress. 1 1 1 1 1Alejandra Yeves , Juan Burgos , Andrés Medina , Irene Ennis , Centro de Investigaciones Cardiovasculares

Dr. H.E. Cingolani, La Plata, Buenos Aires, Argentina

TH-029 Polycystin-1 regulates L-type calcium channel stabilization during mechanical stretch in 2 1,3 2 2 2cardiomyocytes. Ivonne Olmedo , Jaime Riquelme , Diego Varela , Gina Sánchez , Paulina Donoso , Zully

2,3 1 2Pedrozo , Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago, Chile, Facultad 3de Medicina, Universidad de Chile, Santiago, Chile, Advanced Center for Chronic Diseases, Facultad de

Medicina and Facultad de Química y Farmacia, Universidad de Chile, Santiago, Chile1TH-030 A mechanism of calmodulation of the human cardiac sodium channel. Christopher Johnson , Matthew

1 1 1 1Thompson , Markus Voehler , Walter Chazin , Vanderbilt School of Medicine, Nashville, TN, USA1TH-031 Tenascin-C deficiency attenuates abdominal aortic aneurysm progression. Felix Nagel , Anne K

1 1 1 1 1 1 1Schaefer , Philipp Kaiser , David Santer , Attila Kiss , Karola Trescher , Bruno K Podesser , Ludwig Boltzmann Cluster for Cardiovascular Research, Department for Biomedical Research, Medical University of Vienna, Vienna, Austria

TH-032 Critical transcriptional regulation of stress-response kinase JNK2 in CaMKIIδ gene expression in the aging 1 1 1 1 1atrium. Xianlong Gao , Xiaomin wu , Weiwei Zhao , Xun Ai , Loyola University Chicago, Maywood, IL, USA

TH-033 Up-regulation of 5-Hydroxytryptamine receptor signaling in coronary arteries after organ culture. Chun 1 1 1 1Yu Deng , Hui Yang , Su Juan Kuang , Department of Medical Research, Guangdong Cardiovascular

Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou Guangdong, China

TH-034 Target identification of curcumin on ischemic blood flow and anticancer activities by network analysis 1 1and biological approaches. Xuejun LI , School of Basic Medical Sciences, Peking University, Beijing, China

1 2TH-035 The role of mast cell tryptase in the progress of atherosclerosis. Xiuling Zhi , Xiaobo Li , Pohsheng 2 2 1 1 1,2 1Yeong , Hao Zhang , Hongxia Shao , Luanfeng Pan , Lianhua Yin , Training Center of Medical Experiments,

2School of Basic Medical Sciences, Fudan University, Shanghai, China, Department of Physiology & Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, China

TH-036 Intermedin 1-53 attenuates vascular calcification in rats with chronic kidney disease by upregulation of 1 1 1 1 1 1alpha-Klotho. JinRui Chang , Jun Guo , Yue Wang , YueLong Hou , WeiWei Lu , JinSheng Zhang , Yanrong

1 1,2 1,2 1 1 1,2 1 1 1Yu , XiuYing Liu , XiuJie Wang , YouFei Guan , Yi Zhu , Jie Du , ChaoShu Tang , YongFen Qi , Peking 2University Health Science Center, Beijing, China, The Key Laboratory of Remodeling-related Cardiovascular

Diseases, Capital Medical University, Ministry of Education, Beijing, China

TH-037 Impact of high salt independent of blood pressure on PRMT/ADMA/DDAH pathway in the aorta of dahl 1 1 1 1 1 1salt-sensitive rats. Jianjun Mu , Yu Chao , Chao Chu , Tongshua Guo , Zuyi Yuan , Department of

Cardiovascular Medicine, First Affiliated Hospital of Xian Jiaotong University, Xian, China

TH-038 The mechanisms and significance of up-regulation of stomatin expression by glucocorticoid. Ji-Cheng 1 1 1 1 1Chen , Hao-Yu Cai , Yan Wang , Jian Lu , Department of Pathophysiology, the Second Military Medical

University, shanghai, China1 1TH-039 HIP-55 function in endocytosis. Zijian Li , Institute of Vascular Medicine, Peking University Third Hospital,

Beijing, China

TH-040 LncRNA Hand2-AS1, Hand2, and MiR-138-5p crosstalk to participate in VSMC phenotypic switch. 1 1 1Shaoguang Sun , Mei Han , Hebei Medical University, shijiazhuang, China

TH-041 Epac is an essential component of the cAMP-mediated cardioprotection and acts synergically with 1 1 1 1 1 1PKA. Igor Khaliulin , Mark Bond , Zara Dyar , Raheleh Amini , Jason Johnson , M-Saadeh Suleiman ,

1University of Bristol, Bristol, UK

TH-042 Temporal phosphoproteomics to investigate the mechanotransduction of vascular smooth muscle 1 1 1 1cells in response to cyclic stretch. Ying-Xin Qi , Yu-Chen Yang , Xiao-Dong Wang , Institute of

Mechanobiology & Medical Engineering, Shanghai Jiao Tong University, Shanghai, China

TH-043 Involvement of BK channel in differentiation of vascular smooth muscle cells induced by mechanical 1 2 3 1 1 1stretch. Xue-Jiao Wang , Hu-Cheng Zhao , Bo Huo , Ying-Xin Qi , Zong-Lai Jiang , Institute of

2Mechanobiology & Medical Engineering, Shanghai Jiao Tong University, Shanghai, China, Lab of 3Biomechanics, Department of Engineering Mechanics, Tsinghua University, Beijing, China, School of

Aerospace Engineering, Beijing Institute of Technology, Beijing, China

TH-044 Functional and morphological improvements mediated by long-term β-arrestin biased agonism of the AT1R 1 1 2 1in familial dilated cardiomyopathy. David M. Ryba , Jieli Li , Conrad L. Cowan , Brenda Russell , Beata M.

1 1 1 2Wolska , R. John Solaro , University of Illinois at Chicago, Chicago, IL, USA, Trevena, Inc., King of Prussia, PA, USA1,2TH-045 TOR pathway regulates calcium handling in heart tissue through eIF-4E and 4E-BP. Manuela Santalla ,

1 3 1 1,2 1Carlos Valverde , Greco Hernández , Alicia Mattiazzi , Paola Ferrero , Centro de Investigaciones 2Cardiovasculares Dr. H.E. Cingolani, La Plata, Buenos Aires, Argentina, Department of Basic Sciences, University

3of Northwest of Buenos Aires, Pergamino, Buenos Aires, Argentina, Division of Basic Research, National Institute of Cancer (INCan), México City, Mexico

TH-046 NOX2 activity induces lateralization, S-nitrosylation and opening of connexin/pannexin hemichannels, 1 1causing arrhythmogenesis and apoptosis in dystrophic cardiomyopathy. Alejandra Vielma , Mauricio Boric ,



POSTER SESSIONS

2 1 2Daniel Gonzalez , Pontifica Universidad Catolica de Chile, Santiago, Chile, Universidad de Talca, Talca, Chile1TH-047 HGF/Met tyrosine kinase receptor in heart physiology and pathophysiology. Tiziana Crepaldi , Simona

1 1 1 2 2 1Gallo , Stefano Gatti , Valentina Sala , Alessandro Bonzano , Paolo Maria Comoglio , University of Turin, 2Turin, Italy, FPO/IRCCS, Turin, Italy

TH-048 Translocase of the outer mitochondrial membrane 22 is a novel substrate for p38 alpha Mitogen 1 1 2 2Activated Protein Kinase. Eva Denise Martin , Sharwari Verma , Nicholas T. Hertz , Rebecca S. Levin , Alma

2 2 3 4 4L. Burlingame , Kevan M. Shokat , Andrew Gilmore , Goncalo C. Pereira , Nicolas Rognant , Andrew P. 4 1 1 2Halestrap , Michael S. Marber , King's College London, London, UK, University of California San Francisco,

3 4California, USA, University of Manchester, Manchester, UK, University of Bristol, Bristol, UK

TH-049 NFAT and MEF-2 control the expression of calsequestrin-2 in rat cardiomyocytes. Rafael Estrada-1 1 1 1Avilés , Gabriela Rodríguez , Ángel Zarain-Herzberg , Universidad Nacional Autónoma de México, Mexico

city, Mexico

TH-050 Proteins secreted preferentially in response to ER calcium dysregulation protect cardiac myocytes 1,2 1 3from ER stress-induced cell death. Shirin Doroudgar , Donna J. Thuerauf , Mirka Stastna , Haley

1 1 4 1 1Stephens , Erik A. Blackwood , Jennifer E. Van Eyk , Christopher C. Glembotski , San Diego State University, 2San Diego, USA, Department of Cardiology, Angiology, and Pneumology Heidelberg University Hospital and

DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, 3Germany, Institute of Analytical Chemistry of the Academy of Sciences of the Czech Republic, Brno, Czech

4Republic, Advanced Clinical Biosystems Research Institute, Heart Institute and Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, USA

TH-051 Proximal endoplasmic reticulum stress response element is essential for SERCA2 gene basal and 1 1thapsigargin-induced transcription. Jorge Fragoso-Medina , Gabriela Rodríguez , Ángel Zarain-

1 1Herzberg , Universidad Nacional Autónoma de México, Mexico city, Mexico1 1TH-052 Hyperosmotic stress promotes no release in the rat myocardium. Malena Morell , Luis Gonano , Juan

1 1 1Ignacio Burgos , Martin G Vila Petroff , Centro de Investigaciones Cardiovasculares Dr. H.E. Cingolani, La Plata, Buenos Aires, Argentina

1,2 2TH-053 Role of DBC1 protein in the regulation of hypertension. Maria Caggiani , Adriana Carlomagno , Carlos 1,2 1,2 2 1Batthyany , Paola Contreras , Carlos Escande , Facultad de Medicina, Universidad de la República,

2Montevideo, Uruguay, Institut Pasteur Montevideo, Montevideo, Uruguay

Electrophysiology/Arrhythmias

2+ 1TH-061 Switchable cardiac L-type Ca channel transcript by mineralocorticoid pathway. Thassio Mesquita , 1 1 1 2 3Gaelle Auguste , Jessica Sabourin , Gema Ruiz Hurtado , Valérie Rouffiac , Florian Le-Billan , Jérôme

3 1 3 1 1 3Fagart , Florence Lefebvre , Say Viengchareun , Eric Morel , Ana Maria Gomez , Marc Lombès , Jean-Pierre 1 1 Benitah , UMR-S 1180, Inserm, Univ. Paris-Sud, Université Paris-Saclay, Châtenay-Malabry, France,

2 3Imaging and Cytometry Platform, UMR 8081 IR4M, Gustave Roussy Institute, Villejuif, France, UMR-S 1185, Inserm, Univ. Paris-Sud, Université Paris-Saclay, Le Kremlin-Bicêtre, France

TH-062 Meis1 regulates sympathetic target-field innervation: consequences for autonomic nervous system 1 2 1 1induced sudden cardiac death. Jerome Thireau , Fabrice Bouilloux , Charlotte Farah , Sarah Karam , Yves

3 1 2 1 Dauvilliers , Sylvain Richard , Frederic Marmigère , INSERM U1046 -CNRS UMR 9214, Montpellier, France,2 3INSERM U1051, Institute for Neurosciences of Montpellier, Montpellier, France, Sleep Unit, Department of Neurology, Gui-de-Chauliac hospital, Montpellier, France

TH-063 Extracellular matrix metalloproteinase 9 (MMP-9) and tissue endogenous inhibitor (TIMP-1) has significantly associated with cardiovascular dysfunction (CVD) defined by echocardiography. Diego

1 1 2 2Torres Dueñas , Maria Eugenia Niño , Edilberto Eduardo , Manuel Guillermo Hernández , Sergio Serrano 1 1 1Gómez , Daniela Camila Niño Vargas , Universidad Autónoma dde Bucaramanga, Bucaramanga,

2Santander, Colombia, Instituto del corazón de Bucaramanga, Bucaramanga, Santander, Colombia2+TH-064 Interpretation of arrhythmia generation induced by sarcoplasmic reticulum Ca loss using a human

1 1 1myocyte mathematical model. Juan Ignacio Felice , Carlos Valverde , Alicia Mattiazzi , Elena Catalina 2 2 1Lascano , Jorge Antonio Negroni , Centro de Investigaciones Cardiovasculares Dr. H.E. Cingolani, La Plata,

2Buenos Aires, Argentina, Universidad Favaloro, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina

TH-065 Molecular and functional characterization of novel mutation in the cardiac ryanodine receptor gene 1 2 1(RYR2) in a patient with long QT syndrome. Carmen Valdivia , Erika Antunez , Jonathan Hernandez , Todd

1 2 4 3 1 1Herron , Teresa Villareal , Pedro Iturralde , Argelia Mereidos-Domingos , Hector Valdivia , University of 2 3Michigan, Ann Arbor, MI, USA, Universidad Autonoma de Mexico, Mexico City, Mexico, University Hospital of

4Bern, Bern, Switzerland, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico

TH-066 C543 is the reactive cysteine responsible for increased human L-type calcium channel protein function 1 1 2following glutathionylation. Padmapriya Muralidharan , Henrietta Cserne Szappanos , Evan Ingley , Livia

1,3 1Hool , School of Anatomy, Physiology and Human Biology, The University of Western Australia, Crawley, 2 3WA, Australia, Cell Signalling Research, Harry Perkins Institute of Research, Perth, WA, Australia, Victor

54

Chang Cardiac Research Institute, Sydney, NSW, Australia

TH-067 Voltage and calcium dynamics in atrial-like and ventricular-like cardiomyocytes derived from human 1 1 2embryonic stem cells by optical mapping. Sanam Shafaattalab , Eric Lin , Stephanie Protze , Jeehoon

2 2 2 2 3 2 1,4 1Lee , Mark Gagliardi , Yulia Nartiss , Peter Backx , Zachary Laksman , Gordon Keller , Glen Tibbits , Simon 2 3Fraser University, Burnaby, Canada, University of Toronto, Toronto, Canada, Univeristy of British Columbia,

4Vancouver, Canada, Child and Family Institute, Vancouver, Canada1 1TH-068 Isolation of cardiac myocytes from human heart. Caroline Pascarel-Auclerc , Caroline Cros , Sébastien

1 1 1 1 1 1 1Chaigne , David Benoist , Richard Walton , Philippe Pasdois , Marine Martinez , Yunbo Guo , Bruno Stuyvers , 1 1 1 1 2Sébastien Dupuis , Marion Constantin , Dominique Détaille , Thomas Desplantez , Josselin Duchateau , Louis

2 2 1,2 1,2 1 1 1Labrousse , Julien Rogier , Michel Haïssaguerre , Mélèze Hocini , Olivier Bernus , Fabien Brette , IHU- 2LIRYC, INSERM U1045, Université de Bordeaux, Bordeaux, France, CHU Bordeaux, Bordeaux, France

TH-069 Characterization of electrophysiological properties of right ventricular tissue in human using optical 1 1 1 1 1mapping. Caroline Cros , Caroline Pascarel-Auclerc , Richard Walton , David Benoist , Marine Martinez ,

1 1 1 1 1 1Sebastien Chaigne , Yunbo Guo , Bruno Stuyvers , Philippe Pasdois , Sebastien Dupuis , Marion Constantin , 1 1 2 2 2Thomas Desplantez , Line Pourteau , Josselin Duchateau , Louis Labrousse , Julien Rogier , Michel

1,2 1,2 1 1 1Haissaguerre , Meleze Hocini , Olivier Bernus , Fabien Brette , IHU-LIRYC, INSERM U1045, Univeriste de 2Bordeaux, Bordeaux, France, CHU de Bordeaux, Bordeaux, France

1,5TH-070 IL-1β production induces cardiac arrhythmias in diabetic mice. Emiliano Medei , Gustavo Monnerat 1,5 1,5 3 4 4 4Cahli , Micaela Lopez-Alarcon , Oscar Casis , Martin Vila-Petroff , Juan Ignacio Burgos , Marisa Sepúlvera ,

6 6 2 6 1,5Marcelo Bozza , Claudia Paiva , Rosana Bassani , Luiz Vasconcellos , Antonio Carlos Campos de Carvalho , 1Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro/Rio de

2 Janeiro, Brazil, Center for Biomedical Engineering, University of Campinas, Campinas/São Paulo, Brazil,3 4Facultad de Farmacia, Universidad del País Vasco UPV/EHU, Vitoria, Spain, Centro de Investigaciones

5Cardiovasculares Dr. H.E. Cingolani, La Plata, Buenos Aires, Argentina, National Center for Structural 6Biology and Bioimaging – CENABIO/UFRJ, Rio de Janeiro/Rio de Janeiro, Brazil, Instituto de Microbiologia,

Federal University of Rio de Janeiro, Rio de Janeiro/Rio de Janeiro, Brazil

TH-071 Cardiac electrical remodeling study on a type 2 diabetes experimental model. Ainhoa Rodriguez de Yurre 1,2 2 1 1 Guirao , Oscar Casis Sáenz , Emiliano Medei , Universidade de Rio de Janeiro, Rio de Janeiro, Brazil,

2Universidad del País Vasco, Vitoria-Gasteiz, Spain

TH-072 Modelling CPVT1 through patient-specific induced pluripotent stem cell-derived cardiomyocytes reveals aberrant mechano-biological and intracellular calcium handling properties associated with

1 2 1 3 4beta-blocker resistance. Ivana Acimovic , Marwan M. Refaat , Anton Salykin , Franck Aimond , Jan Pribyl , 3 5 1,6 1 3Valerie Scheuermann , Melvin M. Scheinman , Petr Dvorak , Vladimir Rotrekl , Alain Lacampagne , Albano

1,3 1 2C. Meli , Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic, Cardiology Division, Cardiac Electrophysiology Section, American University of Beirut Medical Center, Beirut, Lebanon,

3 4PhyMedExp, University of Montpellier, INSERM U1046, CNRS UMR9214, Montpellier, France, CEITEC, 5Masaryk University, Brno, Czech Republic, University of California, San Francisco Medical Center, San

6Francisco, CA, USA, ICRC, St. Anne's University Hospital, Brno, Czech Republic

TH-073 Melatonin protects against low potassium induced ventricular fibrillation: role of melatonin receptors 1,3 2 3 4 4activation and connexin-43. Emiliano Diez , Tamara Beňova , Natalia Prado , Boris Lipták , Vladimír Knezl ,

1,3 2 2 1Roberto Miatello , Barbara Bačová , Narcisa Tribulová , Instituto de Fisiología, Facultad de Ciencias Médicas, 2Universidad Nacional de Cuyo, Mendoza, Argentina, Institute for Heart Research, Slovak Academy of Sciences,

3 Bratislava, Slovakia, Instituto de Medicina y Biología Experimental de Cuyo, CONICET, Mendoza, Argentina,4Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, Bratislava, Slovakia

TH-074 Restoration of p21-activated kinase (Pak1) activity attenuates arrhythmic activity in a dog model of atrial 1 1 2 3 1 1fibrillation. Jaime DeSantiago , Dan J. Bare , R. John Solaro , Rishi Arora , Kathrin Banach , Rush University,

2 3Chicago, IL, USA, University of Illinois at Chicago, Chicago, IL, USA, Northwestern University, Chicago, IL, USA

Ischemia/Reperfusion Injury

TH-075 Protein factor damage like vector prediction of acute coronary syndrome complicated by acute heart 1 1 1failure. Guzeliya Kayumova , Vladimir Razin , Ulyanovsk state University, Ulyanovsk, Russia

TH-076 The Mitochondrial Calcium uniporter is a therapeutic target in the hypoxia/reoxygenation injury. 1,2 1,2 3 1,3Yuriana Oropeza-Almazán , Christian Silva-Platas , Keith A. Youker , Guillermo Torre-Amione , Gerardo

1,2 1García-Rivas , Cátedra de Cardiología y Medicina Vascular, Escuela de Medicina-Tecnológico de 2Monterrey, Monterrey, Nuevo León, Mexico, Centro de Investigación Biomédica-Hospital Zambrano Hellion,

3Tecnológico de Monterrey, San Pedro Garza García, Nuevo León, Mexico, Methodist DeBakey Heart & Vascular Center, The Methodist Hospital, Houston, Texas, USA

TH-077 Carbonic anhydrase inhibition by benzolamide attenuates myocardial ischemia/reperfusion injury via 1 1p38MAPK-dependent mechanism. Alejandro Ciocci Pardo , Luisa F González Arbeláez , Juliana C

1 1 1 1 1Fantinelli , Romina G Diaz , Bernardo Alvarez , Susana M Mosca , Centro de Investigaciones Cardiovasculares Dr. H.E. Cingolani, La Plata, Buenos Aires, Argentina



POSTER SESSIONS

TH-078 Phospholamban ablation rescues reperfusión arrhythmias in hearts with Ca/calmodulin kinase II constitutive phosphorylation of ryanodine receptors, but not myocardium infarction. Gabriela

1 1 1 2 3 1Mazzocchi , Mariano Di Carlo , Carlos Valverde , Evangelia Kranias , Xander Wehrens , Alicia Mattiazzi , 1 Centro de Investigaciones Cardiovasculares Dr. H.E. Cingolani, La Plata, Buenos Aires, Argentina,2 3Department of Pharmacology and Cell Biophysics, Cincinnati, Ohio, USA, Departments of Molecular Physiology and Biophysics, Medicine (in Cardiology), and Pediatrics, Baylor College of Medicine, Cardiovascular Research Q3 Q4 Institute,, Houston, USA

1TH-079 The use of synthetic wine to delineate the cardioprotective components red wine. Sandrine Lecour , 1 2University of Cape Town, Cape Town, South Africa, University of Stellenbosch, Stellenbosch, South Africa

1TH-080 Simulated ischemia does not mimic stop flow ischemia in perfused mouse hearts. Nehuén Salas , 2 1 2 1 1Yuriana Aguilar Sanchez , Alicia Mattiazzi , Ariel Escobar , Carlos Valverde , Centro de Investigaciones

2Cardiovasculares Dr. H.E. Cingolani, La Plata, Buenos Aires, Argentina, School of Engineering and of Natural Sciences, University of California, Merced, CA, USA

TH-081 Reversible redox modifications of ryanodine receptor ameliorate ventricular arrhythmias in the 1 1 1 1ischemic-reperfused heart. Romina Becerra , Bárbara Román , Mariano N Di Carlo , Juan IE Mariangelo ,

1 2 3 4 1 5Margarita Salas , Gina Sanchez , Paulina Donoso , Guillermo Schinella , Leticia Vittone , Xander H Wehrens , 1 1 1Cecilia Mundiña-Weilenmann , Matilde Said , Centro de Investigaciones Cardiovasculares Dr. H.E.

2Cingolani, La Plata, Buenos Aires, Argentina, Programa de Fisiopatología, Instituto de Ciencias Biomédicas, 3Facultad de Medicina, Universidad de Chile, Santiago de Chile, Chile, Programa de Fisiología y Biofísica,

Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago de Chile, Chile,4 Facultad de Ciencias Médicas, Universidad Nacional de La Plata, CIC-PBA, La Plata, Argentina,5Cardiovascular Research Institute, Department of Molecular Physiology and Biophysics, Department of Medicine (in Cardiology), Pediatrics, Baylor College of Medicine, Houston, USA

TH-082 Extracellular HSP27 and TLR4 exaggerate functional injury in aging hearts following ischemia. Lihua 1 1 1 1 1 1Ao , Yufeng Zhai , Joseph Cleveland , David Fullerton , Xianzhong Meng , University of Colorado Denver,

Aurora, Colorado, USA

TH-083 Non-nuclear estrogen receptor activation reduces cardiac ischemic-reperfusion injury in mice with 1 1 1cardiac specific ablation of ER-alpha. Sara Menazza , Swathi Appachi , Junhui Sun , John

2 3 4 1 1Katzenellenbogen , Benita Katzenellenbogen , Philip W. Shaul , Elizabeth Murphy , Systems Biology Center, 2National Heart Lung and Blood Institute, NIH, Bethesda, MD, USA, Department of Molecular and Integrative 3Physiology, Univ. of Illinois at Urbana-Champaign, Urbana, IL, USA, Department of Chemistry, Univ. of Illinois

4at Urbana-Champaign, Urbana, IL, USA, Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX, USA

TH-084 Xenon administration at reperfusion protects against myocardial infarction in the in vivo mouse heart: 1 1 1 2insight into the mechanisms. Tiziana Rosa , Marleen Forkink , Victoria Pell , Michael P Murphy , Thomas

1 1 2Krieg , University of Cambridge, Cambridge, Cambridgeshire, UK, Medical Research Council Mitochondrial Biology Unit, Cambridge, Cambridgeshire, UK

TH-085 PKG-dependent inhibition of endoplasmic reticulum stress contributes to protective effects of 1vasonatrin peptide against myocardial ischemia/reperfusion injury in diabetic rats. Wenjuan Xing ,

1 1 1Qianqian Dong , Haifeng Zhang , Fourth Military Medical University, Xi'an, China

TH-086 Ischaemic preconditioning protects the heart against ischaemia-reperfusion injury without affecting 1 2 3ischaemic succinate accumulation and metabolism. Victoria Pell , Ana S.H Costa , Angela Logan , Tiziana

1 1 2 3 1 1Rosa , John Mulvey , Christian Frezza , Michael Murphy , Thomas Krieg , Department of Medicine, University of 2 3Cambridge, Cambridge, UK, MRC Cancer Unit, Cambridge, UK, MRC Mitochondrial Biology Unit, Cambridge, UK

2+TH-087 Hypothyroidism reduces cardiac stunning with a mitochondrial regulation of sarcoreticular Ca leak: a 1,2 1 1 1mechano-energetical study. María Inés Ragone , María Lara Lazarte , Alicia E. Consolini , Universidad

Nacional de La Plata, Facultad de Ciencias Exactas, Depto de Ciencias Biológicas, Farmacología, La Plata, 2Argentina, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), La Plata, Argentina

TH-088 The way of administration makes a difference in the effects of genistein on cardiac stunning: mechano-1 1 1energetical study. Germán A. Colareda , Alicia E. Consolini , Universidad Nacional de La Plata, Facultad de

Ciencias Exactas, Depto de Ciencias Biológicas, Farmacología, La Plata, Argentina

TH-089 Depression and risk of cardiovascular diseases in men aged 25-64 years: who program Monica 1,2 1,2 1,2 1,2 1,2–psychosocial. Valery Gafarov , Elena Gromova , Dmitriy Panov , Igor Gagulin , Almira Gafarova ,

1 2Research Institute of Internal and Preventive Medicine, Novosibirsk, Russia, Collaborative laboratory of Cardiovascular Diseases Epidemiology, Novosibirsk, Russia

1,2 2TH-090 Ticagrelor prevented reperfusion arrhythmias in dysmetabolic rats. Nicolas Renna , Emiliano Diez , 2 1,2 1Amira Ponce Zumino , Roberto Miatello , Área de Fisiopatología, Facultad de Ciencias Médicas,

2Universidad Nacional de Cuyo, Mendoza, Argentina, Instituto de Medicina y Biología Experimental de Cuyo, CONICET, Mendoza, Argentina

TH-091 Administration of anabolic steroid during adolescent phase promote long-term increase in the susceptibility to myocardial ischemia/reperfusion injury: involvement of cardiac renin-angiotensin

1,2 1 1system and katp channel. Fernando Seara , Dahienne Oliveira , Raiana Barbosa , José Hamilton 1 2 1 2Nascimento , Emerson Olivares , Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Federal Rural

56

University of Rio de Janeiro, Seropedica, Brazil

Mitochondria

1,2TH-092 Novel software tools for crowdsourcing cardiac protein knowledge in Gene Wiki. Anders O. Garlid , 1,2 1,2 1,2 1,2 1,2 1,3Jessica M. Lee , Jennifer S. Polson , Tevfik Umut Dincer , Sarah B. Scruggs , Ding Wang , Andrew I. Su ,

1,2 1 2Peipei Ping , NIH BD2K Center of Excellence at UCLA, Los Angeles, CA, USA, Departments of Physiology, 3Medicine, and Bioinformatics, University of California, Los Angeles, Los Angeles, CA, USA, Department of

Molecular and Experimental Medicine, The Scripps Research Institute, San Diego, CA, USA

TH-093 CTRP3 promotes the production of mitochondrial reactive oxygen species in vascular smooth muscle 1 1 1 1 1 1 1 1cells. Li-Ling Wu , Han Feng , Jin-Yu Wang , Ming Zheng , Cheng-Lin Zhang , Yuan-Ming An , Li Li , Peking

University Health Science Center, Beijing, China

TH-094 Cystathionine-gamma-lyase/hydrogen sulfide inhibitinging smooth muscle cells proliferation through 1 1 1regulating mitochondrial morphology in diabetic rat. weihua zhang , Jichao Wu , Fan Yang , Changqing

1 1 1Xu , Fanghao Lu , Harbin Medical University, Harbin, China1TH-095 Mitochondrial DAMPs in sterile inflammation after acute myocardial infarction. May-Kristin Torp ,

1 2 1 2 1 1Yuchuan Li , Trine Ranheim , Torun Flatebø , Arne Yndestad , Kåre-Olav Stensløkken , Division of 2Physiology, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway, Research institute of

internal medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway

TH-096 Alpha-MHC MitoTimer Mouse: in vivo mitochondrial turnover model reveals remarkable mitochondrial 1 1 1heterogeneity in the heart. Aleksandr Stotland , Roberta Gottlieb , Cedars-Sinai Heart Institute, Los Angeles, CA, USA

TH-097 Oncotic and apoptotic mechanisms of toxic cardiomyocyte injury: role of mitochondria and gene 1 1 1 1 1expression. L. Maximilian Buja , Priya Weerasinghe , David Loose , Robert Brown , The University of Texas

Health Science Center at Houston, Houston, Texas, USA

TH-098 Monoamine oxidases are major contributors to mitochondrial ROS formation and dysfunction, and 1 2 2cardiac damage in diabetic cardiomyopathy. Soni Deshwal , Chou-Hui Hu , Guido Buonincontri , Marleen

2 1 3 2 4 1,4 1Forkink , Salvatore Antonucci , Mike Murphy , Thomas Krieg , Nina Kaludercic , Fabio Di Lisa , University of 2 3Padova, Padova, Italy, University of Cambridge, Cambridge, UK, Mitochondrial Biology Unit, MRC,

4Cambridge, UK, CNR Neuroscience Institute, Padova, Italy

TH-099 Factors controlling MAO-dependent oxidative stress in myocytes and non-myocytes of the heart. Veronica 1 2 1,3 2 1 1,3Costiniti , Alessandra Castegna , Roberta Menabò , Erika Mariana Palmieri , Marcella Canton , Fabio Di Lisa ,

1 2 3University of Padova, Padova, Italy, University of Bari, Bari, Italy, Institute of Neuroscience CNR, Padova, Italy



Abel, E. Dale, University of Iowa, Iowa, USAAnderson, Mark E., Johns Hopkins University, Maryland, USA Avkiran, Metin, King's College London, London, UKBassani, Rosana, University of Campinas, São Paulo, BrazilBernardi, Paolo, University of Padova, Padova, ItalyBlaxall, Burns, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USABrum, Patricia, University of Sao Paolo, Sao Paolo, BrazilCarrier, Lucie, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyChang, Ching-Pin, Indiana University, Indianapolis, USAChin, Michael T., University of Washington, Seattle, USAColecraft, Henry, Columbia University, New York, USACondorelli, Gianluigi, Humanitas Research Hospital, Milan, ItalyCrottogini, Alberto, Favaloro University, Buenos Aires, ArgentinaDavis, Jennifer, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USADelbridge, Lea, University of Melbourne, Melbourne, Australiadel Monte, Federica, Beth Israel Deaconess Medical Center - Harvard, Boston, Massachusetts, USADi Lisa, Fabio, University of Padova, ItalyDibb, Katharine, Institute of Cardiovascular Sciences, Manchester, UKDomingues Dos Santos, Pierre, Universite de Bordeaux, Bordeaux, FranceDonoso, Paulina, University of Chile, Santiago de Chile, ChileDorn, Gerald, Washington University, St. Louis, Missouri, USADrosatos, Konstantinos, Temple University, Philadelphia, Pennsylvania, USAEaton, Philip, The Ryane Institute, London, UKEisner, David, University of Manchester, Manchester, UKElrod, John, Temple University, Philadelphia, Pennsylvania, USAEnnis, Irene L., Centro de Investigaciones Cardiovasculares Dr. H.E. Cingolani, La Plata, Buenos Aires, ArgentinaEscobar, Ariel, University of California, Merced, California, USAFukuda, Keiichi, Keio University School of Medicine, Tokyo, JapanGarcía, Silvia, Instituto de Investigaciones Médicas “A. Lanari”, Buenos Aires, ArgentinaGiacca, Mauro, Int'l Centre for Genetic Engineering and Biotechnology, Trieste, ItalyGironacci, Mariela, Instituto de Química y Fisicoquímica Biológicas, Buenos Aires, Argentina

ISHR

Gómez, Ana María, University of Paris, Châtenay-Malabry, FranceGómez, Karina, Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Buenos Aires, ArgentinaGorelick, Julia, Imperial College, London, UKGotthardt, Michael, Max-Delbrük-Center for Molecular Medicine, Berlin, GermanyGottlieb, Roberta, Cedars-Sinai Heart Institute, Los Angeles, California, USAGranzier, Henk, University of Arizona, Arizona, USAGustafsson, Asa, University of California-San Diego, California, USAHajjar, Roger J, Icahn School of Medicine at Mount Sinai, New York, USAHarding, Sian, Imperial College, London, UKHausenloy, Derek, Duke-NUS, SingaporeHeller Brown, Joan, University of California -San Diego, California, USAHill, Joseph A., UT Southwestern Medical Center, Dallas, Texas, USAHool, Livia, The University of Western Australia, Crawley, AustraliaHouser, Steven, Temple University, Philadelphia, Pennsylvania, USAHowlett, Susan, Dalhousie University, Nova Scotia, CanadaHsieh, Patrick, Institute for Biomedical Sciences, Taipei, TaiwanKamp, Timothy, University of Wisconsin-Madison, Madison, Wisconsin, USAKelly, Daniel, Sanford Burnham Prebys Medical Discovery, Orlando, Florida, USAKirshenbaum, Lorrie, University of Manitoba, Winnipeg, CanadaKitsis, Richard, Albert Einstein College of Medicine, Bronx, New York, USAKnollman, Bjorn, Vanderbilt University Medical Center, Nashville, Tennessee, USAKoch, Walter, Temple University School of Medicine, Philadelphia, Pennsylvania, USAKomuro, Issei, The University of Tokyo, Tokyo, JapanKranias, Evangelia, University of Cincinnati – College of Medicine, Cincinnati, Ohio, USAKrieger, Jose, University of São Paulo, São Paulo, BrazilLavandero, Sergio, Universidad de Chile, Santiago de Chile, ChileLaver, Derek, University of Newcastle, New South Wales, AustraliaLederer, W. Jonathan, University of Maryland, Baltimore, Maryland, USA

SYMPOSIUM SPEAKERS

58

Lefer, David, Louisiana State University, New Orleans, Louisiana, USALeWinter, Martin, UVM Medical Center, Burlington, Vermont, USALopaschuk, Gary D., University of Alberta, Alberta, CanadaLorenz, Kristina, University of Wurzbürg, Wurzbürg, GermanyMarber, Michael, King's College, London, UKMasaki, Ieda, Keio University School of Medicine, Tokyo, JapanMattiazzi, Alicia, Centro de Investigaciones Cardiovas-culares Dr. H.E. Cingolani, La Plata, Buenos Aires, ArgentinaMcKinsey, Timothy, University of Colorado – Denver, Colorado, USAMcMullen, Julie, Baker IDI Heart and Diabetes Institute, Melbourne, AustraliaMcNally, Elizabeth, Northwestern University, Chicago, Illinois, USAMedei, Emiliano, Federal University of Rio de Janeiro, Rio de Janeiro, BrazilMill, Jose Geraldo, Federal University Espirito Santo, Vitoria, BrazilMiura, Tetsuji, Sapporo Medical University, Sapporo, JapanMolkentin, Jeffery, UC Department of Pediatrics, Cincinnati, Ohio, USAMurohara, Toyoaki, Nagoya University, Nagoya, JapanMurphy, Tish, NIH, Bethesda, Maryland, USAMurray, Andrew, Cambridge, UK.O'Connell, Timothy, University of Minnesota, Minneapolis, Minnesota, USAO'Rourke, Brian, Johns Hopkins University School of Medicine, Baltimore, Maryland, USAOtsu, Kinya, King's College, London, UKOuchi, Noriyuki, Nagoya University Graduate School of Medicine, Nagoya, JapanPaglini-Oliva, Patricia, National University of Córdoba, Córdoba, ArgentinaPalomeque, Julieta, Centro de Investigaciones Cardiovascu-lares Dr. H.E. Cingolani, La Plata, Buenos Aires, ArgentinaPedrazzini, Thierry, Université de Lausanne, Lausanne, SwitzerlandPepe, Salvatore, Murdoch Childrens Research Institute, Melbourne, Australia Pérez, Gustavo, Centro de Investigaciones Cardiovasculares Dr. H.E. Cingolani, La Plata, Buenos Aires, ArgentinaPieske, Burkert, Medical University of Graz, Graz, Austria.Ping, Peipei, David Geffen School of Medicine, UCLA, Los Angeles, California, USAPorrello, Enzo, University of Queensland, Queensland, AustraliaPozzan, Tulio, University of Padova, Padua, ItalyRalphe, J. Carter, University of Wisconsin-Madison, Madison, Wisconsin, USA Regnier, Michael, University of Washington, Seattle, Washington, USARitchie, Rebecca, Baker IDI Heart & Diabetes Institute, Melbourne, AustraliaRobbins, Jeffrey, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USARockman, Howard, Duke University, Durham, North

Carolina, USARomero, Eder, Universidad Nacional de Quilmes, Quilmes, Buenos Aires, ArgentinaSack, Michael, Center for Molecular Medicine, Bethesda, Maryland, USASadoshima, Junichi, Rutgers New Jersey Medical School, Newark, New Jersey, USASaito, Yoshihiko, Nara Medical University, Nara, JapanSandri, Marco, Venetian Institute of Molecular Medicine, Padova, ItalySantulli, Gaetano, Columbia University, New York, USA.Schulze, Christian, Columbia University, New York, USASchulz, Rainer, Justus Liebig University, Geissen, GermanyScorrano, Luca, Venetian Institute of Molecular Medicine, Padua, ItalyShah, Ajay, BHF Chair of Cardiology, King's College Hospital, London, UKShenoy, Sudha, Duke University, Durham, North Carolina, USASipido, Karin, Katholieke Universiteit – Leuven, BelgiumxSolaro, John, University of Illinois, Illinois, USA. Song, Long-Sheng, University of Iowa, Iowa City, Iowa, USASteenbergen, Charles, Johns Hopkins School of Medicine, Baltimore, Maryland, USASussman, Mark, San Diego State University, Heart Institute, San Diego, California, USATaegtmeyer, Heinrich, UT Health Medical School, Houston, Texas, USAThum, Thomas, Hannover Medical School, Hannover, GermanyTian, Rong, University of Washington, Seattle, Washington, USAValdivia, Hector, University of Michigan, Ann Arbor, Michigan, USAValverde, Carlos A., Centro de Investigaciones Cardiovasculares Dr. H.E. Cingolani, La Plata, Buenos Aires, Argentinavan der Velden, Jolanda, VU University Medical Center, Amsterdam, Netherlandsvan Dijk, Sabine J., Institute for Cardiovascular Research, Amsterdam, NetherlandsVila Petroff, Martin, Centro de Investigaciones Cardiovasculares Dr. H.E. Cingolani, La Plata, Buenos Aires, ArgentinaVondriska, Thomas, David Geffen School of Medicine, UCLA, Los Angeles, California, USAWang, Yibin, UCLA, Los Angeles, California, USAWeiss, James, David Geffen School of Medicine, UCLA, Los Angeles, California, USAXiao, Rui-Ping, Peking University, Beijing, ChinaYang, Huangtian, Shanghai Institute for Biological Sciences, Shanghai, ChinaYaniv, Yael, Israel Institute of Technology, Haifa, IsraelZaccolo, Manuela, University of Oxford, Oxford, UKZhang, Jianyi (Jay), University of Minnesota, Minneapolis, Minnesota, USAZhang, You Yi, Institute of Vascular Medicine, Beijing, ChinaZhu, Yi, Tianjin Medical University, Tianjin, China.



Abdelaziz, Iman TH-013Abdulgasanova, Mehriban TH-015, TH-016, TU-028, TU-078, TU-080, WE-014, WE-015, WE-017Abdulgasanov, Ramiz TH-015, TH-016, TU-028, TU-078, WE-014, WE-15, WE-017Abdulrahman, Nabeel TH-013Abraham, Dietmar TH-019Abraham, Gustavo TU-072Abu-El Rub, Ejlal TU-065Abulgasanov, Ramiz TU-080Acimovic, Ivana TH-072Ackers-Johnson, Matthew WE-019Adams, Abbie TU-090Aguilar Sanchez, Yuriana TH-080Ai, Ding TU-003 WE-079Aiello, Ernesto Alejandro TH-010, WE-066, WE-084Aiello, Ignacio WE-084Aimond, Franck TH-072AI-Sharea, Annas WE-038Aisicovich, Maia TU-092Ai, Xun TH-032Alam, Md Jahangir TU-053Al-Jinabi, Mukhallad WE-076Alkhayat, Anwar WE-076Alonso, Hiart WE-086Alvarado, Francisco J TU-085 WE-085Alvarez, Bernardo TH-077 TU-026, WE-100Alvarez, Erika TU-050Alyavi, Aniskhon TU-019Amiad Pavlov, Daria WE-065Amini, Raheleh TH-041Andrade, Kelsey TU-088Anríquez, Cecilia WE-045Anto, Anu WE-025Antonucci, Salvatore TH-098Antunez, Erika TH-065An, Yuan-Ming TH-093Ao, Lihua TH-082Aponte, Angel WE-103Appachi, Swathi TH-083Apple, Fred TU-087Aras Júnior, Roque WE-005Araujo, Amanda WE-073Arauna, Diego TU-027Arige, Vikas TU-079Arnold, Maria WE-043Aronovitz, Mark TU-102Arora, Rishi TH-074Artigas, Rocio WE-021Auguste, Gaelle TH-061Aumayr, Klaus WE-046Auth, Dominik WE-087Avkiran, Metin TU-051 TU-097Ayaz, Omar WE-083Ayme-Dietrich, Estelle TU-036Azevedo, Bruna TU-047Bačová, Barbara TH-073Backs, Johannes TU-101Backs, Tom G WE-093

Backx, Peter TH-067Bahl, Ajay TU-079Baltos, Jo-Anne WE-040Banach, Kathrin TH-074Banas, Sophie TU-036Baraldi, Dhaniel WE-018Barallobre-Barreiro, Javier TH-027Baranyai, Tamás WE-029Barbosa Pereira, Camila WE-005Barbosa, Raiana TH-091 TU-029Bare, Dan J TH-074Barrientos, Genaro TU-022Barrios, Guillermo WE-074Barta, Andrej TU-054Bartholomew Ingle, Sadie WE-025Bassani, José Wilson WE-078Magalhães Bassani, Rosana TH-070 WE-078Bassi, Rekha TU-056Bastos Carvalho, Adriana WE-070Batthyany, Carlos TH-053Bauzá, Maria del Rosario TU-070Baydar, Çetin Lütfi TU-020Baysa, Anton WE-104Beňova, Tamara TH-073Becerra, Romina TH-081Bednarz, Nicole WE-023Behar, Joachim WE-094Belaich, Mariano Nicolas TU-069Bell, James TU-013 WE-012Beltrame, John WE-075Benedict, Cynthia TU-061Benitah, Jean-Pierre TH-061Benoist, David TH-068 TH-069Benson, Vicky TU-012Bentzen, Bo Hjorth WE-089Benz, Alexander WE-087Bernardes, Nathalia WE-073Bernardo, Bianca C TU-091Bernasochi, Gabriel TU-013Bernus, Olivier TH-068 TH-069Berretta, Remus TU-075Bers, Donald WE-080Bideaux, Patrice TU-068Bidwell, Philip WE-039Bielmann, Christelle TU-062Blackwood, Erik A TH-050Blanco, Paula G TU-026Blanton, Robert TU-102Bobadilla, Braulio TU-031Bogdanova, Mariia TU-074Boisvenue, Jamie TU-084Bonanno, Marina WE-024Bond, Mark TH-041Bonzano, Alessandro TH-047Boon, Wah Chin TU-013Booth, Brandon TU-061Booth, Scott TU-089Boric, Mauricio TH-046Boroumandi, Arash WE-026Bouhadja, Houda TU-036

Bouilloux, Fabrice TH-062Bowman, Peter WE-033Bozza, Marcelo TH-070Bradley, Jessica TU-103Brandes, Ralf TU-096 WE-041Brandt, Maarten TH-007Brea, Maria Soledad WE-011 WE-071Breckwoldt, Kaja TH-018Brette, Fabien TH-068, TH-069Brink, Marijke TU-048Broughton, Kathleen WE-007Brown, Robert TH-097Buchanan, William TU-038Buja, L Maximilian TH-097Bull, Ricardo TU-022Buonincontri, Guido TH-098Burgos, Juan Ignacio TH-028, TH-052,TH-070, WE-069Burgoyne, Joseph TU-056Burlingame, Alma L TH-048Bustamante, Mario WE-020Byrne, Nikole J TU-084Cabrera Fischer, Edmundo TH-009Cabrera-Fuentes, Hector WE-037Caggiani, Maria TH-053Cai, Hao-Yu TH-038Calabró, Valeria TU-030Caldiz, Claudia Irma WE-071Callado Sanches, Iris WE-068Cameron, Ewan WE-033Campos de Carvalho, TH-070Antonio CarlosCannon, Presley TU-038Canton, Marcella TH-099Cao, Ting WE-105Cao, Yumeng TU-018Carlomagno, Adriana TH-053Carolina, Zanuzzi TH-026Carrel, Thierry WE-042 WE-043Carrizo Velásquez, Fernanda WE-100Carvalho, Adriana TU-029Casis, Oscar TH-070 TH-071 WE-086Cassambai, Shabana TU-042Castegna, Alessandra TH-099Castro, Pablo WE-020 WE-021Cates, Courtney TU-038Catibog, Norman TU-096Cebova, Martina TU-054Celen, Murat Cenk TU-099Cepeda, Felipe X TU-010Chaigne, Sébastien TH-068 TH-069Chambers, David J WE-046Chandramouli, Chanchal WE-012Chang, Jiang TU-088Chang, JinRui TH-036Chao, Yu TH-037Charchar, Fadi TH-024 TU-089

AUTHOR INDEX

60

Charles, Rebecca TU-056Chazin, Walter TH-030 WE-096Chenaud Neto, Paulo WE-005Chen, Di TU-002Cheng, Caroline TH-007Chen, Guilin TU-002Chen, Ji-Cheng TH-038Chen, Jiyan WE-063Chen, Ju TU-050Chen, Qishan TU-039Chen, Ruifei TU-037Chen, Sifeng TU-015 TU-040Chen, SR Wayne WE-093Chen, Xuanying TH-023Chen, Y Eugene WE-085Chen, Zhanhong TU-021Chen, Zhidan TH-021Cho, Geoffrey WE-006Chong, Mei TH-027Chrifi, Ihsan TH-007Christodoulou, Danos TH-004Christopoulos, Arthur TU-052 WE-040Christ, Torsten WE-092Chu, Chao TH-037, TU-016, TU-017, TU-018Chuo, Chung TU-052 WE-040Chytilova, Anna WE-102Ciancio, María Carolina TH-010, WE-066, WE-084Ciocci Pardo, Alejandro TH-077Clark, James WE-008Cleveland, Joseph TH-082Cochrane, Ashley WE-033Colareda, Germán A TH-088Comoglio, Paolo Maria TH-047Conkbayır, Cenk TU-020Conner, David TH-004Connolly, Kylie TU-014Consolim-Colombo, TU-010Fernanda M Consolini, Alicia E TH-087 TH-088Constantin, Marion TH-068 TH-069Contreras, Paola TH-053Cornea, Razvan WE-080Corvalan, Alejandro WE-021Cosson, Marie Victoire TH-014Costa, Ana SH TH-086Costiniti, Veronica TH-099Coulson, Fiona TH-012 TU-014Cowan, Conrad L TH-044Crepaldi, Tiziana TH-047Cristina Ferreira Freitas, WE-068Sarah Cros, Caroline TH-068 TH-069Crottogini, Alberto TU-069, TU-070, TU-072Cserne Szappanos, Henrietta TH-066

Cuello, Friederike TU-033Cuicui, Liu TU-043Cuniberti, Luis TU-070 TU-072Curl, Claire TH-024 WE-012Dai, Bing TU-039Dal Corso, Simone TU-010Dalton, Nancy TU-050Dariolli, Rafael WE-013Dauby, Pierre TH-009Dauvilliers, Yves TH-062De Angelis, Kátia TU-010 WE-068,WE-073Dean, Sadie TU-042de Boer, Martine TH-007De Giusti, Verónica WE-084 WE-066De Lange, Willem WE-023Delbridge, Lea TH-024, TU-012, TU-013, WE-012DeLeon-Pennell, Kristine TU-038Demion, Marie TU-068Deng, Chun Yu TH-033 TU-086de Nicola, Gian TU-056 WE-044Deo, Minh TU-011DePalma, Steve TH-004DeSantiago, Jaime TH-074De Santis, Maria Chiara TU-032de Santis, Vittorio TU-056Deshwal, Soni TH-098Desplantez, Thomas TH-068 TH-069Détaille, Dominique TH-068De Tapia, Claudia TU-036de Tombe, Pieter TU-100Dewey, Ricardo TU-072Dhingra, Sanjiv TU-065Dias, Danielle WE-073Diaz, Romina G TH-077, WE-011,WE-071, WE-072Di Carlo, Mariano TH-078 TH-081Diering, Simon TU-033Dietl, Wolfgang WE-046Diez, Emiliano TH-073 TH-090Di Lisa, Fabio TH-098 TH-099Di Mattia, Romina TH-010Dincer, Tevfik Umut TH-092Dincer, T Umut TH-006Diness, Jonas Goldin WE-089 WE-098Ding, Lu TH-023Donato, Martin WE-072Dong, Li-Hua TU-001Dong, Qianqian TH-085 TU-023Donoso, Paulina TH-029, TH-081,TU-022, WE-045Donzelli, Sonia TU-033Doroudgar, Shirin TH-050dos Remedios, Cris WE-064

Drahota, Zdenek WE-102Duchateau, Josselin TH-068 TH-069Dudley, Samuel C TU-045Duimel, Hans TH-007Du, Jie TH-036Duncan, Mitch TH-012Duncker, Dirk TH-007Dupuis, Sébastien TH-068 TH-069Duran, Javier TU-034Du, Xiao-Jun TU-011, WE-038, WE-047Dvorak, Petr TH-072Dvornikov, Alexey TU-100Dyar, Zara TH-041Dyck, Jason RB TU-084Dzilic, Elda TH-019 TH-020Eaton, Philip TU-033 TU-056Eduardo, Edilberto TH-063Edvardsson, Nils WE-089Edwards, James WE-075Egger, Marcel WE-081Ehler, Elisabeth TU-050Ehrhart, Juliann TU-103Eid, Freidy WE-090Eimre, Margus WE-101Eldstrom, Jodene WE-099Elsayed, Farid TU-071Elyagon, Sigal WE-095Emes, Robert WE-099Ennis, Irene TH-028 WE-069Enrique, Portiansky TH-026Epah, Jeremy WE-041Ergoren, Mahmut Cerkez TU-020Escande, Carlos TH-053Eschenhagen, Thomas TH-018Escobar, Ariel TH-080Escudero, Daiana Sabrina WE-011Espejo, María Sofía WE-066 WE-084Essawy, Maram WE-080Estrada-Avilés, Rafael TH-049Estrada, Manuel TU-034Etzion, Yoram WE-095Eva Martin, Denise WE-044Evangelista, Ferdinand WE-025Fagart, Jérôme TH-061Faingersh-Klebanov, Anna TH-008Fallouh, Hazem WE-046Fang, Liu WE-048Fang, Xuan TU-003Fantinelli, Juliana WE-022Fantinelli, Juliana C TH-077Fan, Xiaofang TH-023Farah, Charlotte TH-062Farine, Emilie WE-042 WE-043Farjun, Bruna TU-029Federico, Marilén TH-026Fedida, David WE-099Feihl, François TU-062Felice, Juan Ignacio TH-064



Feng, Han TH-093Feng, Yuliang TH-017 TU-067Fenning, Andrew TH-012, TU-014, TU-024Ferdinandy, Péter WE-029Ferguson, Melissa WE-077Feridooni, Hirad WE-026Fernandez Ruocco, Julieta TU-025 WE-086Ferreira, Julio WE-013Ferrero, Paola TH-045Finan, Amanda TU-068Finkelstein, Jose TU-022Finkel, Toren WE-103Fink, Rainer WE-062Finlayson, Siobhan B WE-038Fiorim, Jonaina TU-047Fischer, Jens W TH-027Fischerman, Laura TU-030Flatebø, Torun TH-095Fletcher, Sue TU-090Flynn, Elizabeth TU-038Foo, Roger WE-019Forkink, Marleen TH-084 TH-098Förster, Lorenz TH-019Fraga, Cesar TU-030Fragoso-Medina, Jorge TH-051Franco, Irene TU-032Franzoso, Mauro TU-046Freire Machi, Jacqueline WE-068Frezza, Christian TH-086Fullerton, David TH-082Fu, Yong heng TU-086Gabay, Hovav WE-095Gadeau, Alain TH-013Gafarova, Almira TH-089Gafarov, Valery TH-089Gagliardi, Mark TH-067Gagulin, Igor TH-089Galleano, Monica TU-030Gallet, Romain WE-067Gallo, Simona TH-047Gao, Xianlong TH-032Gao, Xiaoming WE-038Gao, Xiao-Ming WE-047Garcia-Dorado, David WE-037García-Rivas, Gerardo TH-076García Rivello, Hernán WE-024García, Silvia TU-092Garlid, Anders O TU-057 TH-092Garlid, Keith D TU-057Garrett, Michael TU-038Gasser, Bernard TU-036Gatti, Stefano TH-047Gelpi, Ricardo J WE-072Gharaibeh, Nayaf WE-076Ghassemian, Majid TU-050Ghigo, Alessandra TU-032Ghiringhelli, Daniel TU-069Giacca, Mauro TU-077Gillette, Thomas G WE-006Gilmore, Andrew TH-048Giménez, Carlos Sebastián TU-069,

TU-070, TU-072Giricz, Zoltán WE-029Gkanatsas, Yannik WE-034Glembotski, Christopher C TH-050Goetz, Mara TU-033Goldhaber, Joshua I WE-067Gomez, Ana Maria TH-061Gomez-Hurtado, Nieves WE-096Gonano, Luis TH-052, WE-070,WE-093Gong, Hui TH-021Gong, Yongsheng TH-023González Arbeláez, Luisa F TH-077Gonzalez, Daniel TH-046, TU-027,WE-074Goodchild, Traci TU-103Gorham, Joshua TH-004Gorski, Przemek TU-035Goswami, Shyamal K TU-053, TU-055,TU-079Gottlieb, Roberta TH-096Goulart, Jair Trapé WE-078Gou, Lingshan TU-007 TU-041Greene, Steven TU-071Groenendyk, Jody TU-082Gromova, Elena TH-089Grunnet, Morten WE-089 WE-098Guan, YouFei TH-036Guisiano, Morgane TU-068Guo, Jun TH-036Guo, Tongshua TH-037Guo, Tongshuai TU-016, TU-017, TU-018Guo, Yunbo TH-068 TH-069Gupta, Shashi K TH-027Gupta, Sudhiranjan TH-025Gu, Shan-Shan WE-030Hagemeyer, Christoph WE-034Haïssaguerre, Michel TH-068 TH-069Hajjar, Roger TU-035Halestrap, Andrew P TH-048Hall, Michael TU-048Hallström, Seth WE-046Haneke, Travis WE-090Han, Li-Ping WE-047Han, Mei TH-040,

TU-001, TU-008Hansen, Arne TH-018Harding, Sian TH-011Harding, Tristan WE-012Harenkamp, Sabine WE-041Harrap, Stephen TH-024, TU-013,WE-012Harrison, Craig TU-095Harvey, Katherine L TU-042Hasenfuss, Gerd TU-096Hassel, David WE-062 WE-087Hausenloy, Derek WE-037Heineke, Joerg TH-027Hein, Selina WE-062He, Jin Long TU-003

AUTHOR INDEX

WE-079Heller, Lois TU-087Henze, Marcus WE-007 WE-025Hernández, Greco TH-045Hernandez, Jonathan TH-065, WE-085, WE-091Hernández, Manuel Guillermo TH-063Herron, Todd TH-065 WE-091Hertig, Cecilia M WE-024Hertz, Nicholas T WE-008 TH-048He, Weihong WE-033He, Xi WE-035Hidi, László TH-002Hiis, Halvard TH-014Hill, Joseph A WE-006Hirsch, Emilio TU-032Hirt, Marc N TH-018Hnatiuk, Anna TU-069, TU-070, TU-072Hocini, Mélèze TH-068 TH-069Hohmann, Jan David WE-034Holewinski, Ronald WE-067Ho, Ming-Fen TH-001Hool, Livia TH-005,TH-066, TU-090Hoon Choi, Sang WE-008Horowitz, Michal WE-065Houser, Steven TU-061 TU-075Hou, YueLong TH-036Howlett, Susan WE-026, WE-082,WE-083Hsiang-Yu, Yang WE-097Huang, Wei TH-017Huang, Yu TU-006, TU-007, TU-041Huang, Yuan TU-039Hu, Chou-Hui TH-098Hu, Jiawen TU-018Hunt, Francesca WE-008Huo, Bo TH-043Hussain, Afthab TU-042Hussid, Maria F TU-010Hwang, Hyun S WE-096Ingallina, Fernando TU-092Ingley, Evan TH-066Ip, Wendy TU-013 WE-012Irigoyen, Maria Claudia WE-013, WE-068,WE-073Ishikawa, Satoko WE-009Iturralde, Pedro TH-065Ivanov, Alexey TH-015, TH-016, TU-028, TU-078, TU-080, WE-014, WE-015, WE-017Iwaya, Shoji WE-004Jaghoori, Amenah WE-075Jalife, José WE-091Jang, Seung Pil TU-035Janssens, Stefan TH-007Jaquenod De Giusti, Carolina TU-026Jensen, Leonardo WE-013

62

Jeong, Dongtak TU-035Jespersen, Thomas WE-089, WE-092, WE-098Jia, Hang-Huan WE-035Jiang, Jiangming TH-004Jiang, Li TU-040Jiang, Lin TU-067Jiang, Mei TU-015Jiang, Min TU-083Jiang, Nan WE-006Jiang, Zong-Lai TH-043Jianxin, Zhang WE-048Ji, Ensheng WE-003Jing, Jiao WE-049J.M. Wijnker, Paul WE-064John, Dedman TH-026Johnson, Christopher N WE-096 TH-030Johnson, Jason TH-041Johnstone, Victoria TH-005 TU-090Jorg, Manuela WE-040Juanjuan, Tan TU-043Kadaja, Lumme WE-101Kaiser, Philipp TH-031Kallail, Kenneth J WE-090Kalman, Jonathan TU-013Kalous, Martin WE-102Kaludercic, Nina TH-098Kamp, Timothy J WE-091Karam, Sarah TH-062Kararigas, Georgios TH-007Karas, Richard TU-102Karimov, Bekzod TU-019Katus, Hugo A TU-101 WE-087Katzenellenbogen, Benita TH-083Katzenellenbogen, John TH-083Kayumova, Guzeliya TH-075Keller, Gordon TH-067Keller, Kaitlyn WE-082Kellermayer, Dalma TH-002 TU-009Khaliulin, Igor TH-041Khan, Mohsin TU-061 TU-075Khanna, Sanskriti TU-079Khatib, Said WE-076Khmelnitskaya, Karina WE-010Kho, Changwon TU-035Khudoykulov, Akmal TU-019Khullar, Madhu TU-079Kichler, Antoine TH-027Kietadisorn, Rinrada TH-007Kim, Julia WE-006King, Bruce TU-033Kirchhoff, Jeppe WE-098Kiriazis, Helen TU-011 WE-038Kishore, Raj TU-061 TU-075Kiss, Attila TH-019, TH-031, WE-046Kitazume-Taneike, Rika TH-027Klimentova, Jana TU-054Knezl, Vladimír TH-073

Knollmann, Bjorn C WE-096Koch, Sheryl TU-083Koch, Walter TU-061Koivumäki, Jussi T WE-092Kompa, Andrew WE-040Koncsos, Gábor WE-029Kooij, Viola TH-011Kossack, Mandy WE-062Kosta, Sarah TH-009Kosutova, Michaela TU-054Kou, Jiayuan TU-066Kouzu, Hidemichi WE-009Kramer, Anne WE-046Kranias, Evangelia TH-078, WE-039Kreibich, Max TH-019Kreibich, Maximilian TH-020Krieger, José Eduardo WE-013Krieg, Thomas TH-084, TH-086, TH-098Krobert, Kurt Allen TH-014Krssak, Martin TH-019, TH-020Krum, Henry TU-052, WE-040Kuang, Su Juan TH-033Kubo, Hajime TU-075Kumazawa, Takuya TU-094Kuno, Atsushi WE-009Kuster, Diederik WE-064Kyrychenko, Viktoriia WE-006Labrousse, Louis TH-068, TH-069Lacampagne, Alain TH-072, TU-098Lagos, Daniel TU-034Laksman, Zachary TH-067Lam, Chi Keung WE-039Lamin, Victor WE-075Lam, Maggie PY TH-006Lanas, Fernando TU-031Landa, Silvina TU-092Landesberg, Amir TH-008, WE-065Lanfang, Li WE-048Lange, Stephan TU-050Lanza, Fernanda C TU-010Lascano, Elena TH-009, TH-064Lau, Chi Wai TU-007, TU-041Lavandero, Sergio WE-006 WE-020Laver, Derek WE-096Lawson, Roland TU-036Lazarte, María Lara TH-087L Burlingame, Alma WE-008Leandro, Sommese TH-026Lebboukh, Sonia TU-048Le-Billan, Florian TH-061Lecour, Sandrine TH-079 WE-037Lee, Ahyoung TU-035Lee, Angela WC WE-097Lee, Jeehoon TH-067Lee, Jessica M TH-092

Lefebvre, Florence TH-061Lefer, David TU-103Lei, Lei TU-021Lester Sequiera, Glen TU-065Leuschner, Florian TU-101Levasseur, Jody TU-084Levin, Rebecca WE-008Levin, Rebecca S TH-048Levy, Finn Olav TH-014Lewandowski, Paul TH-024Li, Aiying WE-002 WE-003Liao, Dening WE-088Liaudet, Lucas TU-062Li, Dan WE-006Li, Dong-Ling WE-028 WE-035Liel-Cohen, Noah WE-095Li, Guangwei WE-031Liguo, Yang TU-043Li, Hong WE-036Li, Hongzhu WE-032 WE-036Li, Jieli TH-044 WE-007Lijuan, Qian TU-076Lijun, Xie WE-048Li, Li TH-025 TH-093Li, Lina WE-032Lima, Vanessa WE-013Li, Mingchuan TU-032Lindsey, Merry TU-038Lin, Eric TH-067Ling, Zhiqiang TU-021Lin, Qiu xiong TU-086 WE-063Lin, Ruby CY TU-091Lin, Xi TU-088Lin, Ying-Hsi WE-007Li, Peter WE-019Lipták, Boris TH-073Li, Qiang WE-030Liu, Fuqiang TU-016 TU-017Liu, Guan-Sheng WE-039Liu, Jian TU-006Liu, Jin-Jun WE-028Liu, Jin-Long WE-030Liu, Junxu TU-040Liu, Long-Zhu WE-035Liu, Man TU-045Liu, XiuYing TH-036Liu, Yu WE-002Li, Xiaobo TH-035Li, Xiaohong TU-067LI, Xuejun TH-034Li, Xuesong TU-066Li, Xu-Xia WE-030Li, Yang TH-021Li, Yuchuan TH-095 WE-104Li, Zijian TH-039Llanos, Paola TU-022Locatelli, Paola TU-069, TU-070, TU-072



Lofeudo, Juan M TU-026Logan, Angela TH-086Lombès, Marc TH-061Longnus, Sarah WE-042 WE-043Loonat, Aminah WE-008Loose, David TH-097Lopes-Vicente, Wanda R P TU-010Lopez-Alarcon, Micaela TH-070, TU-025, WE-070Loughrey, Christopher WE-033Low, Leanne TH-001Lu, Fanghao TH-094Lu, Jian TH-038Luo, Jiangyun TU-007 TU-041Luong, Le TU-039Lutz, Susanne TU-033Lu, WeiWei TH-036Lux, Árpád TH-002Lu, Yi WE-035Lv, Yongbo TU-018MacCleod, Ken T WE-097Machado Gomes Junior, WE-005Adilson MacRae, Kirsty TU-024Madwed, Jeffrey TU-102 TU-103Maginot, Kathleen R WE-091Magno Martins Dourado, WE-068PauloMahapatra, Nitish TU-079Mahapatra, Nitish R TU-053Makkos, András WE-029Malagueta Vieira, Layse WE-086Malashicheva, Anna TU-074Maleckar, Mary M WE-092Mancilla, Georthan WE-020 WE-021Mannhardt, Ingra TH-018Mano, Miguel TU-077Mao, Xiao-Lei WE-047Marbán, Eduardo WE-067Marber, Michael TU-056, WE-008, WE-044, TH-048Marcia, Kaetzel TH-026Mariangelo, Juan IE TH-081Mariero, Lars Henrik WE-104Marks, Andrew TU-098Marmigère, Frederic TH-062Maroteaux, Luc TU-036Marques, Francine TH-024Martin, Eva Denise TH-048 WE-008Martinez, Marine TH-068 TH-069Martin, Jody TU-100Masson, Grant TU-084Matise, Ilze TU-087Matos e Silva, Thiago WE-005Mattiazzi, Alicia TH-026, TH-045, TH-064, TH-078, TH-080, WE-093Matuskova, Zuzana TU-054Mátyás, Csaba TH-002 TU-009

May, Herman I WE-006May, Lauren TU-052 WE-040Ma, Yonggang TU-038Mayr, Manuel TH-027Mazzocchi, Gabriela TH-078Mazzucotelli, Jean-Phillipe TU-036McCarroll, Charlotte WE-033McCarthy, Joseph TU-102McCune, Sylvia TU-087McKean, David TH-004McMullen, Julie R TH-003 TU-091Medei, Emiliano TH-070, TH-071, TU-025, WE-070, WE-086Meder, Benjamin WE-062Medina, Andrés TH-028Mee, Christopher J TU-042Meikle, Peter J TH-003Meli, Albano C TH-072Mellett, Natalie A TH-003Mellor, Kimberley TU-012 WE-012Mello, Tafne WE-073Meltzer, Anna TH-002Menabò, Roberta TH-099Menazza, Sara TH-083 WE-103Méndez Carmona, Natalia WE-042 WE-043Meng, Dan TU-040Meng, Xianzhong TH-082Meng, Zhang TU-076Mereidos-Domingos, Argelia TH-065Merkely, Béla TH-002 TU-009Mesquita, Thassio TH-061Miao, Sui-Bing TU-001Miatello, Roberto TH-073 TH-090Michels, Michelle WE-064Miki, Takayuki WE-009Mittal, Anupam TU-079Miura, Tetsuji WE-009Mocan, Gamze TU-020Moens, An TH-007Mohsin, Sadia TU-061 TU-075Molenaar, Chris TU-051Monassier, Laurent TU-036Monerrat-Calhi, Gustavo TU-025Mongillo, Marco TU-032 TU-046Mongue-Din, Heloise TU-095Monica, Gallego WE-086Monnerat Cahli, Gustavo TH-070Montecinos, Luis TU-022Montini Ballarin, Florencia TU-072Morales, Cyndi WE-006Morand, Eric F TU-011 WE-038Morandi, Christian TU-048Morel, Eric TH-061Morell, Malena TH-052Morello, Fulvio TU-032Morgan, Patricio WE-022

Morgan, Patricio Eduardo WE-071Mosca, Susana M TH-077Mosqueira, Matias WE-062Moss, Richard WE-023Moudgil, Meenal TU-065Mraiche, Fatima TH-013Mu, Jianjun TH-037, TU-016, TU-017, TU-018Mulla, Wesam WE-095Mulvey, John TH-086Mundiña-Weilenmann, Cecilia TH-081Muralidharan, Padmapriya TH-066Murphy, Andrew WE-038Murphy, Elizabeth TH-083 WE-103Murphy, Michael P TH-084, TH-086, TH-098Murray, Christopher WE-099Nagel, Felix TH-020, TH-031

WE-046Nagy, Csilla Terézia WE-029Nahar, Uma TU-079Najafi, Aref WE-064Nakada, Yasuki TU-094Nakagawa, Hitoshi TU-094Nakano, Tomoya TU-094Nakata, Kei WE-009Nandave, Mukesh TU-004Nartiss, Yulia TH-067Nascimento, José Hamilton TH-091Nascimento Publio Pereira, WE-005AndréNdunda, Paul WE-090Neckar, Jan WE-102Negroni, Jorge TH-009 TH-064Németh, Balázs Tamás TH-002 TU-009Nguyen, Jonathan TU-071Nicklin, Stuart WE-033Nickoloff, Emily TU-061Niederberger, Petra WE-042 WE-043Nield, Alex TU-089Nikolaev, Viacheslav TU-033Niño, Maria Eugenia TH-063Niño Vargas, Daniela Camila TH-063Ni, Rui WE-105Nishizawa, Keitaro WE-009Nitu, Florentin WE-080Niu, Cong TU-040Niu, Li-jing WE-049Nolly, Mariela WE-022Novoa, Ulises TU-027Nuñez, Madelaine TU-027Octavia, Yanti TH-007O'Gara, Peter TH-011Oh, Jae Gyun TU-035Ohwada, Wataru WE-009Oikawa, Masayoshi WE-004Okura, Hiroyuki TU-094Oláh, Attila TH-002 TU-009Olea, Fernanda Daniela TU-069, TU-070, TU-072

AUTHOR INDEX

64

Olgar, Yusuf TU-099Olivares, Emerson TH-091Oliveira Barbosa, André WE-005Oliveira, Dahienne TH-091Oliveira, WE-078Pedro Paulo Martins deOlmedo, Ivonne TH-029 WE-045Onódi, Zsófia WE-029Onoue, Kenji TH-004 TU-094Ooi, Jenny Y Y TU-091Ordokov, Aslan TH-015, TH-016, TU-028, WE-014, WE-015, WE-017Orlowski, Alejandro TH-010, TU-072,WE-066Oropeza-Almazán, Yuriana TH-076Otsu, Kinya TH-027Oyarún, Ingrid WE-020 WE-021Ozdemir, Semir TU-099Ozer, Janet WE-095Ozerkman, Esra TU-020Padmanabhan Iyer, Rugmani TU-038Paiva, Claudia TH-070Paju, Kalju WE-101Palasubramaniam, Jathushan WE-034Palmieri, Erika Mariana TH-099Palomeque, Julieta TH-026Pang, Wei WE-079Pan, Luanfeng TH-035Panov, Dmitriy TH-089Parfenov, Michael TH-004Parks, Randi WE-103Park, Woo Jin TU-035Pascarel-Auclerc, Caroline TH-068 TH-069Pasch, Sebastian TU-033Pasdois, Philippe TH-068 TH-069Pechanova, Olga TU-054Pedrazzini, Thierry TU-048Pedrozo, Zully TH-029 WE-006 WE-045Peet, Nadežda WE-101Pei, Qian-Qian TU-001Pell, Victoria TH-084 TH-086Pena, Milagros TU-072Peng, Tianqing WE-105Peng, Xue WE-031Pentassuglia, Laura TU-048Pepe, Salvatore TU-013Pereira, Goncalo C TH-048Peres Diaz, Ludmila TU-092Perez Abraham, Abigail WE-024Perez, Luis TU-031Pérez, Néstor Gustavo WE-011, WE-071, WE-072Perveen, Irum TU-064Peter, Karlheinz WE-034Peterson, Kirk TU-050Petrucci, Orlando WE-078Pianca, Nicola TU-032

TU-046Piasecki, Angelika TU-033Piirsoo, Andres WE-101Ping, Peipei TU-057, TH-006, TH-092Pinilla, Andrés WE-022Pino, Gonzalo WE-045Piotrkowski, Barbara TU-030Podesser, Bruno K TH-019, TH-020,TH-031, WE-046Põdramägi, Taavi WE-101Polidovitch, Nazari WE-026Polson, Jennifer S TH-092Ponce, Nikol WE-074Ponce Zumino, Amira TH-090Portiansky, Enrique Leo WE-011Pourteau, Line TH-069Prado, Natalia TH-073Prado, Yalena TU-031Preissner, Klaus WE-037Prestes, Priscilla TH-024Pribyl, Jan TH-072Protze, Stephanie TH-067Puhl, Sarah-Lena TU-097Pyle, W Glen WE-077Qin, Cheng Xue TU-011 WE-038Qingyun, Zhang TU-076Qinzeng, Zhang WE-048Qi, Ying-Xin TH-042 TH-043Qi, YongFen TH-036Qi, Zhoucuo WE-063Quan, Jing TU-015Quiroga, Clara WE-020 WE-021Raaijmakers, Antonia WE-012Radin, Judith TU-087Radovits, Tamás TH-002 TU-009Ragone, María Inés TH-087Ralphe, Carter WE-023Ramdhave, Anup TU-004Ramos, Isalira WE-070Rana, Santanu TU-079Ranheim, Trine TH-095Ranieri, Antonella TU-051 TU-097Rashid, Beliza WE-041Razin, Vladimir TH-075Rebbeck, Robyn WE-080Refaat, Marwan M TH-072Rehakova, Radoslava TU-054Reiken, Steven TU-098Renna, Nicolas TH-090Rezende, Flavia WE-041Ricardo Bastos de Macedo, WE-005CristianRichards, Daniel TU-095Richard, Sylvain TH-062 TU-068Rignault-Clerc, Stéphanie TU-062Riquelme, Jaime TH-029 TU-022Ritchie, Rebecca H TU-011

WE-038Rizzo, Agustín WE-024Robia, Seth TU-100Rodriguez De Yurre, Ainhoa WE-086Rodriguez de Yurre Guirao, TH-071AinhoaRodríguez, Gabriela TH-049 TH-051Rodriguez, Hector WE-025Rogier, Julien TH-068 TH-069Rognant, Nicolas TH-048Román, Bárbara TH-081Roosimaa, Mart WE-101Rosa, Tiziana TH-084 TH-086Rose'Meyer, Roselyn TH-001Rosenblatt-Velin, Nathalie TU-062Rose, Robert WE-026 WE-083Rosli, Sarah TU-011 WE-038Rothermel, Beverly A WE-006Rotrekl, Vladimir TH-072Rotter, David WE-006Rouffiac, Valérie TH-061Rouillard, Helène TU-036Rubinstein, Jack TU-083 WE-039Rudyk, Olena TU-056Ruedlinger, Jenny TU-031Rüegg, Markus A TU-048Ruiz Hurtado, Gema TH-061Ruiz-Meana, Marisol WE-037Ruppert, Mihály TH-002 TU-009Russell, Brenda TH-044 WE-007Rutkovskiy, Arkady TU-074Ruusalepp, Arno WE-101Ryba, David M TH-044Saavedra, Nicolás TU-031Sabourin, Jessica TH-061Sadayappan, Sakthivel WE-061Said, Matilde TH-081Saitoh, Shu-ichi WE-004Saito, Yoshihiko TH-004 TU-094Salaices, Mercedes TU-047Salas, Margarita TH-081Salas, Nehuén TH-080Sala, Valentina TH-047Salazar, Luis A TU-031Saleem, Nikhat TU-055Salykin, Anton TH-072Sanchez-Freire, Vero WE-007Sanchez, Gina TH-081, TU-022, TH-029, WE-045Sanchez, Sebastian TH-015, TH-016, TU-028, TU-078, TU-080, WE-014, WE-015, WE-017Sandri, Marco TU-032Sano, Motoaki WE-001Santalla, Manuela TH-045Santer, David TH-019, TH-020, TH-031, WE-046



Santulli, Gaetano TU-098Sapunar, Sabina WE-095Sareen, Niketa TU-065Sarkar, Sagartirtha TU-079Sarmah, Elina WE-007Sawyer, Greta TU-095Sayour, Alex Ali TH-002 TU-009Scammells, Peter TU-052 WE-040Schaefer, Anne K TH-031Scheid, Lisa WE-062Scheinman, Melvin M TH-072Schell, Richard TU-101Scheuermann, Valerie TH-072Schinella, Guillermo TH-081Schlüter, Klaus WE-037Schneider, Edoardo TU-077Schneider, Jay W WE-006Schnelle, Moritz TU-096Schobesberger, Sophie TU-033Schröder, Katrin TU-096 WE-041Schuman, Mariano TU-092Schürmann, Christoph WE-041Sciarretta, Sebastiano TU-032Scruggs, Sarah B TH-092Seara, Fernando TH-091Sebhat, Iyassu TU-103Seidman, Christine TH-004Seidman, Jonathan TH-004Semsarian, Christopher TH-005Seppet, Enn WE-101Sepúlveda, Marisa WE-070 WE-093 TH-070Sequeira, Vasco WE-064Serrano Gómez, Sergio TH-063Seyler, Claudia WE-087Sganga, Leonardo TU-070Shafaattalab, Sanam TH-067Shah, Ajay TU-095 TU-096Shang, Dandan TU-008Shannon, De'Aries TU-038Shan, Zhi xin TU-086Shao, Hongxia TH-035Shao, Xiying TU-021Sharkey, Leslie TU-087Sharma, Rajni TU-079Shattock, Michael J WE-097Shaul, Philip W TH-083Shende, Pankaj TU-048Sheykhzade, Majid WE-098Shi, Guangbin TU-045Shlyakhto, Eugenii WE-010Shokat, Kevan WE-008Shokat, Kevan M TH-048Siciliano, Alexandre TU-029Silva, Ivson WE-013Silva-Platas, Christian TH-076Silveira-Filho, WE-078Lindemberg MotaSimões, Maylla TU-047Singla, Saloni TU-091Skibsbye, Lasse WE-089

WE-092Slone, Samuel TU-083Small, Kersten TU-102 TU-103Smolin, Nikolai TU-100Soerensen, Ulrik Svane WE-089Soetkamp, Daniel WE-067Solaro, R John TH-044

TH-074, WE-007Somekawa, Satoshi TU-094Souza, WE-078Felipe Augusto da SilvaSpeerschneider, Tobias WE-089Starosta, Timothy TU-075Stastna, Mirka TH-050Stathopoulou, Konstantina TU-033Stensløkken, Kåre-Olav TH-095

TU-074, WE-104Stephens, Haley TH-050Stevens, Ellie TU-012Stojkovic, Stefan TH-020Stoltz, Jordane TU-036Stotland, Aleksandr TH-096Stuklis, Robert WE-075Stuyvers, Bruno TH-068 TH-069Su, Andrew I TH-092Suleiman, M-Saadeh TH-041Sultonova, Gulnoza TU-019Sung, Miranda M TU-084Sun, Junhui TH-083Sun, Shaoguang TH-040Sun, Shu Yu TU-102 TU-103Sun, Weiming WE-032Sun, Yihua TH-022Sun, Yong TH-022Sussman, Mark TU-071Su, Yi-Dan WE-047Svendsen, Jesper Hastrup WE-089Swinnen, Melissa TH-007Szabó, Gábor TU-009Szabó, Lilla TH-002 TU-009Takeishi, Yasuchika WE-004Tang, ChaoShu TH-036Tang, Chun mei TU-086Tang, Juan TU-002Tan, Ji-Liang WE-030Tanno, Masaya WE-009Tatekoshi, Yuki WE-009Telerman, Stephanie TU-095Temel, Sehime G TU-020Tevaearai Stahel, Hendrik WE-042 WE-043Tham, Yow Keat TH-003Thapa, Dibesh WE-044Thireau, Jerome TH-062 TU-068Thomas, Colleen J WE-038Thomas, David WE-080Thompson, Emely WE-099Thompson, Matthew TH-030Thuerauf, Donna J TH-050Thum, Thomas TH-027Tian, Ye TU-066, TU-073

AUTHOR INDEX

Tibbits, Glen TH-067Tobias, Anthony TU-087Toischer, Karl TU-096Tomasic, Ivan WE-025Török, Marianna TH-002 TU-009Torp, May-Kristin TH-095 WE-104Torre-Amione, Guillermo TH-076 TU-088Torres Dueñas, Diego TH-063Toscano, Cindy TU-047Toth, Andras TU-101Tottef, Tamara WE-093Tranter, Michael TU-083Trescher, Karola TH-019

TH-020, TH-031, WE-046Tribulová, Narcisa TH-073Trojanek, Sandra TH-019Trombetta, Ivani C TU-010Troupes, Constantine TU-061 TU-075Tsushima, Robert WE-026Ueta, Cintia WE-013Ulmer, Bärbel TH-018Uzokov, Jamol TU-019Uzoqova, Manzura TU-019Vaage, Jarle TU-074 WE-104Valdes, Alvaro WE-074Valdivia, Carmen TH-065 WE-091Valdivia, Hector H TU-085

WE-085, WE-091, TH-065Valen, Guro WE-104Valverde, Carlos TH-045

TH-064, TH-078, TH-080van der Velden, Jolanda WE-064Van Eyk, Jennifer E TH-050 WE-067van Waveren, Alannah TH-012Varela, Diego TH-029Vargas, Lorena WE-100Varga, Zoltán V WE-029Varma, Upasna TU-012Vasconcellos, Luiz TH-070Vassallo, Dalton TU-047Vazquez-Prieto, Marcela TU-030Vecchio, Elizabeth TU-052Vella, Rebecca TU-024Venkatraman, Vidya WE-067Verdejo, Hugo E WE-020 WE-021Verheyen, Fons TH-007Verma, Sharwari TH-048Viana, Fabiano WE-075Vielma, Alejandra TH-046Viengchareun, Say TH-061Vila Petroff, Martín WE-069

WE-070, WE-093TH-052, TH-070

Vilarinho, Karlos Alexandre WE-078de SouzaVilla-Abrille, María C WE-072Villareal, Teresa TH-065Vindhyal, Mohinder Reddy WE-090

66

Vindhyal, Shravani WE-090Viola, Helena TH-005 TU-090Viotti, Manuel WE-070Vitiello, Libero TU-046Vittone, Leticia TH-081Voehler, Markus TH-030Vogel, Juri WE-041Waeber, Bernard TU-062Wakimoto, Hiroko TH-004Waller, Lauren TU-050Walton, Richard TH-068 TH-069Wang, Bing TU-052Wang, Chun Jiong TU-003Wang, Danning WE-088Wang, Ding TH-092Wang, Jianzhi TU-005Wang, Jiaxing WE-079Wang, Jingjing WE-003Wang, Jin-Yu TH-093Wang, Li TU-007Wang, Siwang TU-023Wang, Xiao-Dong TH-042Wang, Xiaojia TU-021Wang, Xiaowei WE-034Wang, XiuJie TH-036Wang, Xue-Jiao TH-043Wang, Xuerui TH-023Wang, Yan TH-038Wang, Yang TU-018Wang, Yan-ling WE-049Wang, Yigang TH-017Wang, Yuanyang TU-002Wang, Yue TH-036Warren, Chad WE-007Watt, Fiona TU-095Waxman, Joshua S TH-017Weeks, Kate TU-051 TU-097Weerasinghe, Priya TH-097Wehrens, Xander TH-078Wehrens, Xander H TH-081Wei, Can WE-031 WE-036Wei, Xiangxiang TU-040Wen, Guanmei TU-039Werner, Tessa TH-018Westhoff, Maartje WE-099White, Paul TU-052 WE-040Wichmann, Ignacio WE-021Wilson, David WE-075Wilton, Steve TU-090Winter, James WE-097Wolska, Beata M TH-044Worthington, Michael WE-075Wu, Jichao TH-094Wu, Li-Ling TH-093Wullschleger, Marcel WE-081Wu, Xiaomin TH-032Wu, Yueheng TU-067Wyss, Rahel WE-042 WE-043Xander, Wherens TH-026Xiao, Han TU-037

Xiao, Qingzhong TU-039Xiao, Rui-Ping WE-027Xia, Xiao-hong WE-049Xing, Wenjuan TH-085Xing, Yi TH-006Xin, Xin TU-008Xu, Changqing TH-094, WE-031, WE-032, WE-036Xu, Lifen TU-048Xu, Man WE-035Xu, Shenhua TU-021Xu, Weizhen TU-021Xu, Xie TU-040Yamasan, Bilge Eren TU-099Yang, Chunjie TH-021Yang, Dong Kwon TU-035Yang, Fan TH-094Yang, Huang-Tian WE-030Yang, Hui TH-033Yang, Jingyi TU-098Yang, Liming TU-066Yang, Mei TU-039Yang, Min TU-086Yang, Tingli TU-088Yang, Xiangsheng TU-088Yang, Yuan H TU-011 WE-038Yang, Yu-Chen TH-042Yaniv, Yael WE-094Yano, Toshiyuki WE-009Yan, Shuai TU-002Yeong, Pohsheng TH-035Yeves, Alejandra TH-028 WE-069Yin, Lianhua TH-035Yi, Xin TU-088Yndestad, Arne TH-095Youker, Keith TU-088 TH-076Young, Martin E TU-084Yuan, Qi TU-098Yuan, Zuyi TH-037 TU-016 TU-017Yue, Xiaojing TU-088Yue, Xin WE-067Yu, Xiao-Jiang WE-028 WE-035Yu, Xiyong TH-017Yu, Xi-Yong TU-067Yu, Yanrong TH-036Yu, Ying TU-002Zacchigna, Serena TU-077Zaglia, Tania TU-032 TU-046Zambrano, Carmen TU-027Zang, Wei-Jin WE-028 WE-035Zanucci, Carolina TH-026Zarain-Herzberg, Ángel TH-049 TH-051Zavala, Maite R WE-072Zeng, Jingya TH-022Zentilin, Lorena TU-077Zhai, Yufeng TH-082Zhang, Bin WE-063

ISHR XXII WORLD CONGRESS • APRIL 18-21, 2016Buenos Aires - Argentina


Zhang, Cheng-Lin TH-093Zhang, Gu TU-021Zhang, Guoping TH-021Zhang, Haifeng TH-085 TU-023Zhang, Hao TH-035Zhang, hongsong TU-041Zhang, Jian TU-002Zhang, Jianhua WE-091Zhang, Jianyi TU-040Zhang, JinSheng TH-036Zhang, Li TU-039Zhang, Lulu WE-105Zhang, Mengjie TU-100Zhang, Mengzhen WE-063Zhang, Min TU-096Zhang, Rui WE-067Zhang, Ting WE-027Zhang, Weihua TH-094Zhang, Xiaoyi TH-021Zhang, Xu TU-003 WE-079Zhang, Yan WE-027Zhang, Youyi TU-037 TU-044Zhang, Yu WE-063Zhao, Hu-Cheng TH-043Zhao, Lei TU-007Zhao, Ming WE-035Zhao, Weiwei TH-032Zhao, Yanting WE-091Zheng, Dong WE-105Zheng, Ming TH-093Zheng, Qingqing TH-023Zheng, Wenling TU-018Zheng, Yan-Jun WE-030Zhi-hui Miao, Zhi-hui WE-049Zhiqiang, Yan TU-043Zhi, Xiuling TH-035Zhong, Shilong WE-063Zhong, Zhaoyu TU-066Zhou, Anyu TU-045Zhu, Jianhua TU-039Zhu, Jie ning TU-086Zhu, Wen si TU-086Zhu, Xing TU-066Zhu, Yi TH-036, TU-003, WE-079Zihlavnikova Enayati, TU-074KatarinaZilblich, Craig TU-103Zitron, Edgar WE-087Zoccaratto, Anna TH-027Zordoky, Beshay TU-087Zou, Yunzeng TH-021Zuo, Shengkai TU-002

67

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ISHR XXII WORLD CONGRESS is supported by:

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Cover design (Argentinean artists): Antonio Berni; Juan Carlos Castagnino; Milo Lockett; Emilio Pettoruti; Raúl Soldi y Benito Quinquela Martín.

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