jurnal reading fix.doc

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BAB I PENDAHULUAN Kontrol terhadap re pr od uct ive tract infection adalah masalah kesehatan ter golon g pen ting di beb erap a negara ya ng memilik i kon sekuen si jauh bagi keseha tan, sektor sosial dan eko nomi (www. who.i nt). Sekitar 5% ibu hamil me mi li ki ri si ko te rkena in feks i va gi na akib at ba kt er i. e nu rut American Pregnancy Association, !"% # $"% ibu hamil di merika Serikat terkena infeksi vag ina aki bat bak teri. &ni lah penyebab uta ma keg ugu ran dan kel ahi ran bayi prematur yang terjadi pada trimester ke#' kehamilan. a gino sis bakte rialis () adalah infeksi vagina yang paling umum di kalangan wanita usia subur. Kondisi ini terkenal karena menyebabkan komplikasi parah yang berkaitan dengan kesehatan reproduksi perempuan. *ada kehamilan+ a gin osi s ak teri alis terk ait den gan per sali nan pre term, K* pre term dan kori oamnioni ti s. a gi nosis ba kt er ial is bukan me rupakan suatu perad anga n ataup un peny akit menular seksual, tetapi merupaka n sebuah kondi si ketik a flora normal vagina predominan#la-toba-illus yang menghasilkan hydrogen peroksida diiga ntikan oleh bakteri anaero b, Gardnere lla vaginalis spesies Mobiluncus, dan Myoplasma hominis (iller dkk dala m /unningham, '""0) 1r aktus genetali s wani ta memi lik i sis tem pert ahanan terhadap invasi mik roo rga nis me termasuk pat oge n yang men ula r mel alui hubungan seksual. Sis tim imun ya ng dimili ki ter bagi ata s kul it dan muko sa, innate immunity dan adap tive immun ity. Secretor y Leuko cyte Pro tease Inhib itor (S2*&) merupa kan mediator yang penting pada imunitas bawaan traktus genitalis. S2*& berperan pada pertahanan imun mukosal dengan mengurangi inflamasi dan menghambat infeksi bakteri, jamur, dan virus dengan melindungi makrofag (*udjiati, '"!"). S2*& dan elafin juga hadir selama kehamilan. S2*& hadir dalam konsentrasi yang sangat tinggi dalam sekret lendir serviks, sebagai kun-i penghalang infeksi saluran kel ami n bag ian atas sela ma keh ami lan (e in et al. '""'). Secretory Leukocyte Protease Inhibitor (S2*&) ada lah protei n rantai tun gga l ya ng sangat kat ionik Reading jurnal Immunology 2012 Page 1

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JURNAL TRANSLATE fix.doc

Journal Reading fix.doc