Major Endocrine Organs

HORMONAL DISEASE

PANCREAS

OVARIUM & TESTIS

ADRENAL

THYROID

REPRODUCTION

METABOLISM

GROWTH & DEVELOPMENT

ENERGY & NUTRITION

HYPER / HYPO SECRETIONDISEASE

HORMONAL DISEASE (MOST)

GROWTH DISORDERSSTRUMA ( HYPO & HIPERTHYROIDI)

DIABETES MELLITUSLIPID DISORDERS

INFERTILITYMENSTRUATION & MENOPAUSE

CARCINOMAOSTEOPOROSIS

HIPERTENSI

THYROID

PANCREAS

OVARIUM & TESTIS

ADRENAL

Waah capek sekali

Bapak kurang minum

hormon seks

Gara-gara hormon seks

POROS HIPOTALAMUS-HIPOPISIS-OVARIUM/TESTIS

Ovarian hormones

OVARIUM

ESTROGEN ( blood stream)

UTERUS; VAGINA; MAMMA

HYPOTALAMUS

PROGESTERON

F S H L H

HYPHOPHYSIS (gland) GnRH

Paired ovaries in the abdominopelvic cavity produce estrogens and progesterone

They are responsible for: Maturation of the reproductive organsAppearance of secondary sexual

characteristicsBreast development and cyclic changes in the

uterine mucosa

Gonads: Female

ESTROGEN & PROGESTERONE

SIDE EFFECT / TOXICITYPHYSIOLOGIC / BALANCE

HYPER HORMONAL

NON HORMONAL ?MENSTRUAL DISTURBANCE

CLINICAL USE

Hypo secretion; menopause (HRT) Hormonal contraceptive

ANTI ESTROGEN

Preparat : ClomiphenTamoxiphene

Clinical use: infertility ---- induce ovulation

( an ovulatoir)

Mech of action : blocking estrogen receptor

FSH & LH increase

Mechanism of action ANTI ESTROGEN

OVARIUM

ESTROGEN ( blood stream) Clomiphene

UTERUS; VAGINA; MAMMA

HYPHOPHYSIS (gland)

PROGESTERON

F S H

L H

TESTIS

TESTOSTERONE ( blood stream)

Penis, Larynx, skeleton, Muscle massPubic and axillary hair

HYPOTALAMUS

F S H L H

HYPHOPHYSIS (gland)

GnRH

Testes located in an extra-abdominal sac (scrotum) produce testosterone

Testosterone:Initiates maturation of male reproductive organsCauses appearance of secondary sexual

characteristics and sex driveIs necessary for sperm productionMaintains sex organs in their functional state

Gonads: Male

TESTOSTERONE

SIDE EFFECT / TOXICITY

NON HORMONAL ?

CLINICAL USE

HYPOGONADISM, STIMULATE RBC,INCREASE MUSCLE BULK

Hormonal contraceptive

MECHANISM OF GLUCOCORTICOID

Dexamethasone

Prenisone,Triamcinolone

Cortisol

Aldosteron

Fludocortisone

Spironolactone

Mifepristone

Aminoglotethimide

Metyrapone

Ketoconazole

INFLAMATION

SIDE EFFECT / TOXICITY

HYPERGLYCEMIA CUSHING SYNDROOM

HYPERTENSION

PREDNISON (STEROID)

The hyperglycemic effects of glucagon and the hypoglycemic effects of insulin

Regulation of Blood Glucose Levels