lessons from conducting research in an american …super7/31011-32001/31471.pdflessons from...
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Lessons from conducting research in an American Indian community:
The Pima Indians of Arizona
Pittsburgh,December 13th, 2007
Peter H. Bennett, M.B., F.R.C.P.Scientist Emeritus
National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, U.S.A.
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Phoenix
Sacaton
GilaRiver
GilaRiver
Indian
Reservation
Salt River N
10 miles
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What did we learn in 1963?
• RA (and AS) common in this population– We provided care and treatment for the
affected • Community willing to take part in research• Diabetes appeared to be a very common
problem• Further assessment of diabetes and its
complications is needed
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1965 Diabetes survey
• 75g OGTT• Anthropometry• Height and weight• Medical history (+ medical record review)• Physical examination- B.P., ophthalmoscopy, (joints)
etc.• and in those age30+: Retinal photos, ECG, • Plasma glucose, serum creatinine, cholesterol• Urine glucose & protein (and if +ve,
protein/creatinine ratio)
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What did we learn in 1965?• The Pima have the world’s highest reported prevalence
of diabetes– Diabetes has a major impact on the community
• Plasma glucose levels show a bimodal distribution– Current criteria for diagnosis seem inappropriate
• Retinopathy and nephropathy are frequent complications• Pregnancy in the diabetic is associated with considerable
excess perinatal mortality• Further assessment of determinants of diabetes and its
complications is indicated• A longitudinal study could elucidate risk factors for
diabetes and its complications– Very little known about the development and course of
the disease
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• Addressing a problem that community perceived as important
• Discussed ideas for longitudinal study with community leaders– Ask for their suggestions – Become aware of local cultural sensitivities
• Obtain appropriate community approval and endorsement (beyond the IRB)– E.g. Tribal council
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Characterize clinical features of diabetes mellitus in Pima IndiansIdentify risk factors for diabetes mellitusDetermine its pathogenesis Distribution and determinants of its complications
Initial Goals of Longitudinal Study
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Establishing the Longitudinal Population-based Study
Detailed census of community including identification of parents, siblings and children
Examine all aged 5 years and overRepeat examination at two-yearly intervals
75g OGTTAnthropometry-Height and weightMedical history (+ medical record review)Physical examination- B.P., ophthalmoscopy, etc.
and in those age15+: Retinal photos, ECG, Plasma glucose, serum creatinine, cholesterolUrine glucose & protein (and if +ve, protein/creatinine ratio)
Initiate Pregnancy study -Third trimester GTT and examination of newborn-birth weight and congenital anomalies
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Risk Factors for Diabetes
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Diabetes in Pima by Parental Diabetes
None Father Mother BothDiabetes in Parents
0
20
40
60
Pre
val e
n ce
(%)
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Incidence of Diabetes by BMI in Pima Indians
Knowler, Am J Epidem, 1981.
<20 -25 -30 -35 -40 >40Body Mass Index (kg/m2)
0
20
40
60
80C
ases
/ 100
0 p e
rson
-yr
Obese
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Five-year Incidence of Type 2 Diabetesin Pimas aged 25-44yrs by BMI
Adapted -Knowler AJEpid 1981;113:144-56.
20-25 20-25 25-30 30-35 35+BMI (kg/meters squared)
0
10
20
30
40 In
cide
nce
(%)
Type 2 DM in Parents Neither One affected Both affected
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Type 2 DM and Current Leisure Activityin Pima Indians, aged 37-46 years
Low Medium High Low Medium High
Physical Activity
0
5
10
15
20
25
Pre
vale
nce
( %)
MEN WOMEN
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Pathogenesis
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<55 55-90 91-145 >145
Fasting Insulin (uU/ml)
0
2
4
6
8
10
12
Cum
ulat
ive
Inc i
denc
e (%
)Five-year Incidence of Type 2 Diabetes
in Pima Indians with Normal Glucose Tolerance by fasting insulin levels
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Diabetes Incidence (cases/1000 p-yr) by Insulin Sensitivity and Secretion
0
25
50
75
100
Inci
denc
e
High Mid LowHigh
MidLow
Sensitivity
Secret
ion
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Complications
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Incidence of Proteinuria byDuration of Diabetes
Kidney Int 35:681-687, 1989
Cas
es/ 1
,000
Per
son -
Ye a
rs
0 5 10 150
50
100
150
2002h glucose (mg/dl)
>450250-449<250
0 5 10 150
50
100
150
200Systolic BP (mm Hg)
>160140-159<140
Duration of Diabetes (years)
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Incidence of End-Stage Renal Disease in Diabetic Patients, 1984-93
Whites Blacks Pima Indians0
500
1000
1500
Cas
es p
e r 1
0 0,0
00/y
e ar Relative Incidence
Whites 1.0Blacks 2.1xPima 9.2 x
Age-sex-adjusted
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Pregnancy study
Perinatal mortality
Congenital defects
Long-term effects of diabetic pregnancy on offspring
Type 2 diabetes in childhood and adolescence
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Prevalence of Diabetes in Children if Mother had Diabetes while Pregnant
10-14 15-19 20-24 25-29
Age (years)
010203040506070
Pre
vale
nce
( %) Mother's Diabetes
PrediabeticDiabetic
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0
2
4
6
5-9 10-14 15-19 5-9 10-14 15-19
Age (years)
% w
ith D
iabe
tes
Diabetes Prevalence in Pima Indian Children1965-1969 1998-2002
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Risk Factors for Diabetes in Children and Adolescents
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Ten-year cumulative incidence of diabetes in Pima Indians aged 5-19years by Parental diabetes
McCance DR et al, Diabetologia 37; 617-23, 1994
5-9 10-14 15-19Age (years)
0
5
10
15
Cum
ulat
ive
I nci
d en c
e(%
) Parental DiabetesNeitherOne diabetic parentBoth parents diabetic
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Prevalence of Diabetes by Exposure to Diabetes in Utero
5-9 10-14 15-19Age (years)
0
5
10
15
20
25
Pre
vale
nce
(%)
No Yes
Dabelea D et al, Diabetologia 41:904-910, 1998
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Sib Pairs Discordant for Diabetes and Intrauterine Exposure to Diabetes
7
21
Born Before Born After0
5
10
15
20
25
Num
ber o
f sib
pai
rs
OR=3.0, p<0.01
Mother's Diagnosis
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Percent of Offspring exposed to Diabetes in utero in three time intervals
1967-76 '77-86 '87-96Time Period
0
2
4
6
8
Per
cent
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Prevalence of Type 2 Diabetes in Pima Indians aged 20-39yrs by Birth Weight
Age-Adjusted<2
500
-3000
-3500
-4000
-4500
>450
0
Birth Weight (g)
0
10
20
30
Prev
alen
ce o
f dia
b ete
s ( %
)
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Parental Risk of Diabetes according to birth weight of children
1 2 3 4 5Child's Birth Weight Quintile
0
0.5
1
1.5
2H
azar
d R
a te
Ra t
io FatherMother
Lindsay, RS et al, Diabetes 49:445-449, 2000
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Prevalence of Type 2 Diabetes and Infant Feeding
* Adjusted for age, sex, birth date, obesity, birth weight parental diabetes and maternal diabetes in pregnancy
10-19 20-29 30-39Age (years)
0
5
10
15
20
25
30P
reva
lenc
e ( %
)Breast Fed > 2 monthsNever Odds Ratio*=0.42
(95% CI=0.18-0.96)
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Prevalence of Diabetes in 5-19 year oldPima Children by Relative Weight
< 100 100-119 120-139 140-159 160 +
Relative Weight (%)
0
2
4
6
Pre
vale
nce
( %)
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Cumulative Incidence of Nephropathyby Age at Diagnosis and Attained Age
20 30 40 50Attained Age (years)
0
10
20
30
Inci
denc
e (%
)
Age at Diagnosis15-24 25-3435-44
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Death rates in Pima Indians with onset of diabetes <20years
0153045607590
5-14 15-24
25-34
35-44
45-54
55-64
Diabetes No diabetes
Age (years)
Dea
ths/
1000
pyr
s
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Consequences of youth-onset type 2 diabetes
Pregnancies are likely to be diabetic pregnanciesChildren will develop diabetes at an early age
High likelihood of vascular complications by 30-40 years of age
Likely to develop ESRD in the 40 year age rangePremature mortality
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Prevention
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Diabetes Incidence Rates by Diabetes Incidence Rates by EthnicityEthnicity(DPP)(DPP)
0
4
8
12
C au cas ian(n =1768 )
Afr icanAm erican
(n =645 )
Hisp an ic(n =508 )
Am ericanIn d ian
(n=171)
As ian(n =142 )
L ifes tyle Metfo rm in Placebo
Cas
es p
er 1
0 0 p
erso
nC
a ses
per
100
per
son --
yry r
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Ongoing Intervention studies
• DPPOS• Look AHEAD• Early intervention in prevention of renal
disease
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Some Achievements from the Pima Indian Study
Identified phenotypic (and etiologic) differences in Type 1 (IDDM) and Type 2 diabetes mellitus
Established criteria for definition and diagnosis of diabetes mellitus (Now the International Criteria)
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Some Achievements from the Pima Indian Study
Established obesity as a major risk factor for type 2 diabetes
Established importance of insulin resistance as a key feature of Type 2 diabetes
Demonstrated that blood pressure predicts development and progression of diabetic retinopathy and nephropathy
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Some Achievements from the Pima Indian Study
Demonstrated that intrauterine environment programs the development of obesity and diabetes in offspring
Established nature of relationships of diabetes to low and high birth-weight
Established that infant feeding practice is an important determinant of diabetes risk
Established that type 2 diabetes can be prevented or delayed by lifestyle intervention or metformin
Identified several genetic loci that confer genetic susceptibility to diabetes
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Pima Indians of the Gila River Indian Community have contributed enormously to knowledge and understanding of the causes of Type 2 diabetes and its complications, ways in which the disease is now treated, and possible ways by which it may be prevented.
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Guidelines for successful community-based programs
• Address a problem that community perceives as important
• Discuss ideas with community leaders– Ask for their suggestions – Become aware of local cultural sensitivities
• Obtain appropriate community approval and endorsement beyond the IRB– E.g. Tribal council
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Guidelines for successful community-based programs
• Engage local community members in the work to the greatest extent possible
• Start slowly (and simply) to build confidence• Explain the goals and procedures to
participants in simple understandable language-best done by a local community member
• Try to provide a “service” to the community that is not readily available
• Provide feedback to participants and the community—never enough
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Guidelines for successful community-based programs
• Be prepared for delays in approval process
• Can the work be done in conjunction with or as a component of other ongoing activities?
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Thank you