lipid anabolism
DESCRIPTION
LIPID ANABOLISM. acetyl-CoA carboxylase. fig 21-1. acetyl-CoA carboxylase. fig 21-1. acetyl-CoA carboxylase. fig 21-1. condensation. fig 21-2. reduction. fig 21-2. dehydration. fig 21-2. reduction. fig 21-2. synthesis of fatty acids…. fig 21-4. synthesis of fatty acids…. - PowerPoint PPT PresentationTRANSCRIPT
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rh
Lecture 13 Slides
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LIPIDANABOLISM
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fig 21-1
acetyl-CoA carboxylase
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fig 21-1
acetyl-CoA carboxylase
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fig 21-1
acetyl-CoA carboxylase
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fig 21-2
condensation
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fig 21-2
reduction
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fig 21-2
dehydration
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fig 21-2
reduction
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fig 21-4
synthesis of fatty acids…
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fig 21-4
synthesis of fatty acids…
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fig 21-4
acyl carrier protein(ACP) in E. coli
a lot like…
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fig 16-3coenzyme A
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AcCoA-ACPtransacetylase(AT)
fig 21-6 (4th)
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malonyl-CoA-ACP transferase(MT)
fig 21-6 (4th)
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b-ketoacyl-ACP synthase (KS)
fig 21-6
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b-ketoacyl-ACP reductase (KR)
fig 21-6
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b-hydroxyacyl-ACP dehydratase (HD)
fig 21-6
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enoyl-ACP reductase (ER)
fig 21-6
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acetylCoA-ACP transacetylase (AT)
fig 21-6
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fig 21-7
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fig 21-7
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fig 21-7
fatty acidsynthasesvariationsof the FAScomplex
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fig 21-9
two sources of NADPH…
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fig 21-10
citrate as a source of building blocks…
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fig 21-10
citrate lyase as an anabolic carbon source…
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fig 21-10
and a minor NADPH source…
majority supplied by pentose phosphate p.way
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fig 21-11
Allosteric regulation of fatty acid synthesis
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fig 21-11
Phosphorylation of fatty acid synthesis
active un-phosphorylated ACC makes cytosolic filaments
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fig 21-12
now what…?elongationdesaturation
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fig 21-14.
providedby plants:polyunsat.fatty acids
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fig 21-15.
cyclooxygenasea key reaction of inflammation inmammals…
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fig 21-15.
aspirin: a cycloxygenase inhibitor
willowbark
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box 21-2
a family of COX inhibitors: NSAIDs
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box 21-2
a family of COX inhibitors: NSAIDs
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box 21-2
Two COX isozymes
COX1gastric
functions
COX2inflammation
pain fever
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box 21-2
COX2-specific inhibitors
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COX2-specific inhibitors
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COX2-specific inhibitors
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lipid menagerie
phospholipid
triglyceride
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phospholipids or glycerophospholipids
phophatidylcholine phophatidylserine
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fig 21-17.
mobilizing glycerol
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fig 21-17.
addingacyl groups
phosphatidic acida phospholipid
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fig 21-18.
more phospholipidsor glycerides…
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fig 21-23.
anatomy of a phospholipid
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anothertrinucleotide-based carrier:CTP
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fig 21-24.
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The isoprene unit:a branched lipid structure
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fig 21-32
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fig 21-33
four stagesof cholesterolsynthesis
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fig 21-33
four stagesof cholesterolsynthesis
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fig 21-33
four stagesof cholesterolsynthesis
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fig 21-34.
stage 1mevalonateproduction
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fig 21-34.
stage 1mevalonateproduction
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fig 21-34.
stage 1mevalonateproduction
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fig 21-34.
stage 1mevalonateproduction
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fig 21-34.
synthesisof mevalonate
first stepsof ketonebody formation
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fig 21-35
stage 2: conversion toactive isoprenes
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fig 21-36.
“head” “tail”
condensation of isoprenes
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fig 21-36.
further condensation of isoprenes
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fig 21-36.
and even more condensation of isoprenes
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fig 21-37.
from squalene to cholesterol
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fig 21-38.
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fig 21-39.
LDL:the infamouslipoprotein
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fig 21-39
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fig 21-40
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fig 21-40
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fig 21-44
regulationof cholesterolmetabolismboth uptakeand synthesisare involved
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box 21-3
As does nature, so does pharma...
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fig 21-45
sterolsgalore!
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fig 21-47
isoprenoidsgalore!!