lipids eric niederhoffer siu-som storage (neutral)membrane (polar) g s fa p pacms/os fa tag plgl...
TRANSCRIPT
CH
HC
H2C
CH=CH(CH2)12CH3
NH
HO
Lipids
Eric Niederhoffer
SIU-SOM
Storage (neutral) Membrane (polar)
G SFAP
H2C
HC
H2C
(CH2)14CH3
(CH2)7CH=CH(CH2)7CH3
(CH2)16CH3
OC
OC
OC
O
O
O
FA
FA
P A C MS/OS
FA
TAG
PL GL
GPL SL SL
Glycerophospholipids
H2C
HC
H2C
O
O
O
C(CH2)14CH3
C(CH2)7CH=CH(CH2)7CH3
P
O
O
O
O-
O X
H2C
HC
H2C
O
O
O
C(CH2)14CH3
C(CH2)7CH=CH(CH2)7CH3
P
O
O
O
O-
O H
General Structure PA
PC PI45BP
Net ChargepH 7 = -1
Net ChargepH 7 = 0
Net ChargepH 7 = -4
G3P
H2C
HC
H2C
O
O
O
C(CH2)14CH3
C(CH2)7CH=CH(CH2)7CH3
P
O
O
O
O-
O CH2CH2N(CH3)2
H2C
HC
H2C
O
O
O
C(CH2)14CH3
C(CH2)7CH=CH(CH2)7CH3
P
O
O
O
O-
O
H
H
OPO32-
OH
HH
OH
OPO32-H
HO H
SphingolipidsCH
HC
H2C
NH
O
C(CH2)22CH3
X
OHO
CH=CH(CH2)12CH3
CH
HC
H2C
NH
O
C(CH2)22CH3
H
OHO
CH=CH(CH2)12CH3
CH
HC
H2C
NH
O
C(CH2)22CH3
Glc
OHO
CH=CH(CH2)12CH3
CH
HC
H2C
NH
O
C(CH2)22CH3
Glc-Gal
OHO
CH=CH(CH2)12CH3
CH
HC
H2C
NH
O
C(CH2)22CH3
OHO
CH=CH(CH2)12CH3
Glc Gal Neu5Ac
GalNAc
S
General Structure Cer Sm
PC
GlcCb(neutral GL)
LacCer(Gb)
Gan(i.e., blood groups)
CH
HC
H2C
NH
O
C(CH2)22CH3
PO3CH2CH2N(CH3)2
OHO
CH=CH(CH2)12CH3
PhospholipasesPLA1
PLA2
PLC
PLD
PI45BP
DAG
IP3
H2C
HC
H2C
O
O
O
C(CH2)14CH3
C(CH2)7CH=CH(CH2)7CH3
P
O
O
O
O-
O
H
H
OPO32-
OH
HH
OH
OPO32-H
HO H
Review Questions
What are the general lipid classes? What are the general lipid structures? How do the PLs act (site, products)?