lupus eritematosus sistemik fk unbrah
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Lupus Eritematosus Sistemik
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Definisi
• Merupakan penyakit autoimmun• Ditandai dengan di produksinya antibodi
terhadap komponen2 inti sel• Terutama mengenai wanita
( wanita : pria = 5 : 1 )• Usia produktif ( umur 15 – 40 tahun )• Berhubungan dengan respon imun spesifik thd
MHC II yaitu HLA- DR2 dan HLA-DR3
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Etiologi• Etiologi multifaktor
terdapat pengaruh genetik, lingkungan dan hormonal• Faktor2 di atas akan menginduksi dan mengaktifasi
sel T CD4, sehingga kemampuan toleransi thd self antigen menghilang
• Sel T autoreaktif menginduksi sel B• Terbentuk autoantibodi yang seterusnya membentuk
komplek antigen-antibodi• Antibodi yang terbentuk disebut ANA
( Anti Nuclear Antibody )
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Aktifasi sel T oleh APC
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• Tiga tipe penyakit Lupus1. Sistemik Lupus Eritematosus2. Diskoid Lupus Eritematosus3. Cutaneus Lupus Eritematosus
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Manifestasi klinis
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1. Gejala konstitusional
• Demam tanpa bukti adanya infeksi• Fatigue/kelelahan• Penurunan bert badan
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2. Gejala organ sistemik
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Diagnosis SLE
SLE = memenuhi 4 dari 11 kriteria
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Pemeriksaan penunjang
• 1. Hemoglobin, lekosit, hitung jenis sel, laju endap darah (LED)
• 2. Urin rutin dan mikroskopik, protein kwantitatif 24 jam, dan bila diperlukan kreatinin urin.
• 3. Kimia darah (ureum, kreatinin, fungsi hati, profil lipid )
• 4. PT, aPTT pada sindroma antifosfolipid• 5. Serologi ANA, anti-dsDNA, komplemen (C3,C4)• 6. Foto polos thorax
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