magna cum laude)€¦ · he graduated with masters degree in medical sciences >magna cum laude)...

MutindaC.Kyama,Ph.D.

Contact: kcleophas/yahoo.com 3 mkyama/4kuat.ac.ke

Mutinda C. Kyama, is a Biomedical Scientist and a faculty >Senior LecturerA in the Department of Medical Laboratory

Sciences, School of Biomedical Sciences, College of Health Sciences, Jomo Kenyatta University of Agriculture and

Technology. He has special research interest in studying the pathogenesis of endometriosis, ovarian cancer, breast

cancer, cervical cancer3 and stem cell biology and investigate the role of stem cells in the pathophysiology of uterine

benign and malignant tumours. His interest in biomedical science stems from a deep philosophical commitment to

cure diseases. Purpose is the engine that powers his life, and like most scientists who have lost loved ones to

terrible illness, an interest in understanding how disease cause suffering and mortality changed readily and deeply

into a drive to contribute to the development of the neMt generation of medical care. In 1998, Kyama earned his

bachelors degree in Biochemistry from the University of Nairobi, Kenya. In 1999, he 4oined the Institute of Primate

Research, Karen-Nairobi, Kenya to serve as Research Assistant in the female reproduction research programme. In

2002, he visited the Coriell Institute for Medical Research, New Jersey, USA as an intern to gain further training in

Molecular Biology. After completing his training in Molecular Biology techniWues, he was awarded a masterXs

scholarship in September 2002 by the Katholieke University of Leuven >KULeuvenA, Belgiumand moved to Europe to

pursue his masters training. He graduated with Masters degree in Medical Sciences >Magna Cum Laude) in 2004

from KULeuven, Belgium. Dr. Kyama in 2005, received the prestigious KULeuven Interfaculty Council for

DevelopmentCooperationgrant(InterfacultaireRaadvoorOntwikkelingssamenwerking(IRO)Doctoralawardin

Biomedical Sciences) to carry out his doctoral thesis work at the Laboratory of EMperimental Gynaecology

>Department of Obstetrics and Gynaecology, University Hospital Gasthuisberg, KULeuven, BelgiumA and was

awarded a doctor of Biomedical Sciences >Mechanisms of Human DiseaseA on September 2009, under the

mentorship of Prof. Dr. Thomas M. DXHooghe. The title of his doctoral thesis was: Endometriosis: New insight in

pathogenesis and search for potential biomarkers. He was a visiting postdoctoral fellow at the Laboratory of

EMperimental Gynaecology >University Hospital Gasthuisberg, KULeuven, BelgiumA in 2011 under the mentorship of

Prof. Dr. Thomas M. DXHooghe as a recipient of IROspecializationaward offered by KULeuven Interfaculty Council

for Development Cooperation. Dr. Kyama is also a recipient of the WorldEndometriosisSocietyRodolpheMaheaux

Travelaward(2011). This award is given in recognition of outstanding research conducted by individuals who are

young researchers in endometriosis. He has co-authored over 50 scientific articles published in internationally peer-

reviewed 4ournals and contributed several book chapters. He has also presented over 50 abstracts at

international^local meetings and has also been invited speaker to international symposium. He has been a member

of European Society of Human Reproduction and Embryology, cum member of the Special Interest Group in

Endometriosis and Endometrium from 2003 to 2009, member of Belgium Society for Reproductive Medicine from

2003 to 2009, and a member of the World Endometriosis Society since 2008. Associate Faculty Member of the

Faculty of 1000 Medicine from 2008 to 2011. Member of the Kenya Society for Immunology since 2011. Member of

the editorial team of the 4ournal of Clinical Immunology and Immunopathology, the International Journal of

Reproductive Medicine, the African Journal of Medicine and Health Sciences Research and SM Journal of

Gynecology and Obstetrics. He is serving as a board member of the Endometriosis Foundation of Kenya.He is adhoc

reviewer of several international 4ournals including Human Reproduction, Gynecological Surgery, American Journal

of Reproductive Immunology, Molecular Human Reproduction and Gynecologic b Obstetric Investigation. He

currently has active grants in endometriosis, breast cancer, cervical cancer and endometrial stem cells.

PUBLICATIONS(InternationalPeer‐ReviewedJournalsandBookchapters)

1. Vodoladkaia A, Yesilyurt BT, KyamaCM, Bokor A, Schols D, Huskens D, Meuleman, C, Peeraer K, Tomassetti C,

Lambrechts D, DXHooghe T, Fassbender A. Vascular endothelial growth factor pathway in endometriosis:

Genetic variants and plasma biomarkers. Fertil Steril 201f Apr3 105 >4A: 988 - 9f.

2. Hussein M, Chai CD, Kyama CM, Mwenda JM, Palmer SS, DXHooghe TM. c-Jun NH2-terminal Kinase >JNK-A

inhibitor Bentamapimod reduces induced endometriosis in baboons: an assessor-blind placebo-controlled

randomided study. Fertil Steril. 201f Mar3 105 >3A: 815-824.

3. DelvouM B, DXHooghe TM, KyamaC, Koskimies P, Hermans RJJ, Dunselman G, Romano A. Inhibition of type 1

17h-hydroMysteroid-dehydrogenase impairs the synthesis of 17h-estradiol in endometriosis lesions. J Clin

Endocrinol Metab. 2014 Jan3 99 >1A:27f-84.

4. Kyama CM, Falconer H, Chai D, Mihalyi A, Cuneo S, Mwenda JM, DXHooghe TM. Menstrual endometrial

supernatant may induce stromal endometriosis in baboons. Front Biosci (Schol Ed) 2014 Jan 136:1f-28.

5. SundWvist J, iu H, Vodoladkaia A, Fassbender A, Kyama C, Bokor A, Gemdell-Danielsson K, D'Hooghe TM,

Falconer H. Replication of endometriosis-associated single-nucleotide polymorphisms from genome-wide

association studies in a Caucasian population. Hum Reprod. 2013 Mar;28 (3):835-9.

6. Dancet EA, Brknnstrlm M, Brasky K, Chai D, Chan AW, Conn PM, Else J, Falconer H, Fadleabas AT, Farah IO,

Goddeeris BM, Golos TG, Hau J, Hearn JP, Kairiuki TM, KyamaCM, Lebovic DI, Mwenda JM, Ndung'u J, Nyachieo

A, Parker J, Slayden OD, Stouffer RL, Strauss JF, Taylor HS, Vanderpoel S, Westergaard JG, melinski M, D'Hooghe

TM. The Role of Scientists and Clinicians in Raising Public Support for Animal Research in Reproductive Biology

and Medicine. Biol Reprod. 2013 Feb 7;88 (2):33. doi: 10.1095/biolreprod.112.105908.

7. Falconer H, SundWvist J, Hong i, Vodoladkaia A, Fassbender A, KyamaCM, Bokor A, DnHooghe TM. Analysis of

common variations in tumor-suppressor genes on chr1p3f among Caucasian women with endometriosis.

Gynecol Oncol. 2012 Nov3 127: 398-402.

8. Vodoladkaia A, El-Aalamat Y, Popovic D, Mihalyi A, Bossuyt i, Kyama CM, Fassbender A, Bokor A, Schols D,

Huskens D, Meuleman C, Peeraer K, Tomassetti C, Gevaert O, Waelkens E, Kasran A, De Moor B, D'Hooghe TM.

Evaluation of a panel of 28 biomarkers for a non-invasive diagnosis of endometriosis. Hum Reprod. 2012

Sep327>9A:2f98-711.

9. Fassbender A, Verbeeck N, Blrnigen D, Kyama CM, Bokor A, Vodoladkaia A, Peeraer K, Tomassetti C,

Meuleman C, Gevaert O, Van de Plas R, O4eda F, De Moor B, Moreau Y, Waelkens E, D'Hooghe TM. Combined

mRNA microarray and proteomic analysis of eutopic endometrium of women with and without endometriosis.

Hum Reprod. 2012 Jul3 27>7A:2020-9.

10. De Graaff AA, DelvouM B, DXHooghe T, KyamaC, Dunselman G, Romano A. Paired-BoM gene 2 downregulation in

endometriosis correlates with low epidermal growth factor receptor level. Hum Reprod. 2012 Jun327>fA:1f7f-

84.

11. Fassbender A, Waelkens E, Verbeeck N, Kyama CM, Bokor A, Vodoladkaia A, Van de Plas R, Meuleman C,

Peeraer K, Tomassetti C, Gevaert O, O4eda F, De Moor B, DXHooghe TM. Proteomics Analysis of Plasma for Early

Diagnosis of Endometriosis.Obstet Gynecol. 20123 119: 27f - 285.

12. Vodoladkaia A, Bossuyt i, Fassbender A, KyamaCM, Meuleman C, Peeraer K, Tomassetti C, D'Hooghe TM. A

high sensitivity assay is more accurate than a classical assay for the measurement of plasma CRP levels in

endometriosis.Reprod Biol Endocrinol. 2011, Aug 93 9 >1A:113.

13. Fassbender A, Overbergh L, Verdrengh E, Kyama CM, Vodoladakaia A, Bokor A, Meuleman C, Peeraer K,

Tomassetti C, Waelkens E, Mathieu C, DXHooghe TM. How can macroscopically normal peritoneum contribute

to the pathogenesis of endometriosiso Fertil Steril. 2011 Sep3 96 >3A: f97 - 9.

14. SundWvist J, Falconer H, Seddighdadeh M, Vodoladkaia A, Fassbender A, KyamaCM, Bokor A, Stephansson O,

Padyukov L, Gemdell-Danielsson K, DnHooghe MT. Ovarian cancer-associated polymorphisms in the BNC2 gene

among women with endometriosis. Hum Reprod. 20113 26>8A: 2253-7.

15. Kyama CM, Mihalyi A, Gevaert O, Waelkens E, Van de Plas R, Meuleman C, DXHooghe TM. Evaluation of

endometrial biomarkers for semi-invasive diagnosis of endometriosis. Fertil Steril. 20113 Mar 153 95>4A:1338-

1343.

16. SundWvist J, Falconer H, Seddighdadeh M, Vodoladkaia A, Fassbender A, Kyama C, Bokor A, Stephansson O,

Padyukov L, Gemdell-Danielsson K, DnHooghe TM..Endometriosis and autoimmune disease: Association of

susceptibility to moderate^severe endometriosis with CCL21 and HLA-DRB1. Fertil Steril. 20113 95 >1A:437-40.

17. Fassbender A, Simsa P, KyamaCM, Waelkens E, Mihalyi A, Meuleman C, Gevaert O, Van de Plas R, De Moor B,

DXHooghe TM. TRIdol treatment of secretory phase endometrium allows combined proteomic and mRNA

microarray analysis of the same sample in women with and without endometriosis. Reprod Biol Endocrinol.

2010 Oct 213 8>1A:123.

18. Dassen H, Punyadeera C, DelvouM B, Schulkens I, Marchetti C, Kamps R, Klomp J, Di4cks F, de Goei4 A, DXHooghe

TM, KyamaC, Ederveen A, Dunselman G, Groothuis P, Romano A. Olfactomedin-4 regulation by estrogen in the

human endometrium reWuires epidermal growth factor signalling. Am J Pathol. 20103 177>5A: 2495-508.

19. Simsa P, Mihalyi A, Schoeters G, Koppen G, KyamaCM, Den Hond EM, Fpllp C, DXHooghe TM. In a case-control

study increased eMposure to dioMin-like compounds is associated with endometriosis in women. Reprod

BioMed Online 20103 20: f81 - f88.

20. Mihalyi A, Gevaert G, KyamaCM, Simsa P,Pochet N, Meuleman C, Billen J, Blanckaert N, Vodoladkaia A, Fulop

V, DXHooghe TM. Non-invasive diagnosis of endometriosis based on a combined analysis of siM plasma

biomarkers. Hum Reprod .20103 25: f54-f4.

21. KyamaCM.Endometriosis: New insight in pathogenesis and search for potential biomarkers. Leuven University

Press. Thesis Book 2009.

22. Kyama CM, Mihalyi A, Simsa P, Falconer H, Fulop V, Mwenda JM, Tomassetti C, Peeraer K, Meuleman C,

DXHooghe TM. Role of cytokines in the endometrial-peritoneal cross-talk and development of endometriosis.

Front in Biosci. 20093 1: 444 - 454.

23. Guo SW, Simsa P, KyamaCM, Mihqlyi A, Fpllp V, Othman EE, D'Hooghe TM. Reassessing the evidence for the

link between dioMin and endometriosis: from molecular biology to clinical epidemiology. Mol Hum Reprod

20093 15 >10A: f09-24.

24. DXHooghe TM, KyamaCM, Chai D, Fassbender A, Vodoladkaia A, Bokor A, Mwenda JM. Nonhuman primate

models for translational research in endometriosis. Reprod Sci. 20093 16:152 - f1.

25. Bokor A,KyamaCM, Vercruysse L, Fassbender A, Gevaert O, Vodoladkaia A, De Moor B, DXHooghe TM. Density

of small diameter sensory nerve fibers in endometrium: a semi-invasive diagnostic test for minimal to mild

endometriosis. Hum Reprod. 20093 24 :3025 - 32.

2f. Fassbender A, D'Hooghe T, Mihalyi A, KyamaC, Simsa P, Lessey BA. Plasma C3a-des-Arg levels in women with

and without endometriosis. Am J Reprod Immunol. 20093 62: 187-95.

27. DelvouM B, Groothuis P, DXHooghe TM, Kyama C, Dunselman G, Romano A. Increased production of 17h-

estradiol in endometriosis lesions is the result of impaired metabolism. J Clin Endocrinol Metab. 20093 94:87f -

83.

28. DXHooghe TM, KyamaCM, Mwenda JM. Baboon model for endometriosis. In VandeBerg J, Williams-Blangero S,

Tardif S Eds. The Baboon in Biomedical Research. Springer publishers, 20093 139 - 15fpp.

29. KyamaCM, Overbergh L, Mihalyi A, Silvio C, Chai D, Debrock S, Mwenda JM, Mathieu C, Nugent N, DXHooghe

TM. Effect of recombinant human Tumor Necrosis Factor alpha >rhTBP-1A and GnRH antagonist on the

eMpression of inflammatory cytokines, adhesion and growth factors in endometrium and endometriosis tissues

from baboons. Fertil Steril. 20083 89: 1306 - 1313.

30. KyamaCM, Overbergh L, Mihalyi A, Meuleman C, Mwenda JM, Mathieu C, DXHooghe TM. Endometrial and

peritoneal mRNA eMpression of aromatase, cytokines and adhesion factors in women with endometriosis. Fertil

Steril 2008 3 89:301 - 310.

31. KyamaCM, Mihalyi A, Simsa P, Mwenda JM, Meuleman C, DXHooghe TM. Non-steroidal targets in the diagnosis

and treatment of endometriosis. Curr Med Chem. 20083 15: 100f - 1017.

32. D'Hooghe TM, Nyachieo A, Chai DC, KyamaCM, Spiessens C, Mwenda JM. Reproductive research in non-

human primates at Institute of Primate Research in Nairobi, Kenya >WHO Collaborating CenterA: a platform for

the development of clinical infertility serviceso Hum Reprod 20083 doi: 10.1093^humrep^den1f4.

33. DXHooghe T, Vodoladkaia A, Kyama CM, Mwenda JM, Simoens S. Health economics of endometriosis. In:

Rombauts, Tsaltas, Maher b Healy Eds. Endometriosis Edition. Blackwell Publishers3 2008: 1 - 1fpp.

34. Kyama CM, Mihalyi A, Chai D, Simsa P, Mwenda JM, DXHooghe TM. Baboon model for the study of

endometriosis. Women's Health 20073 3: f37 - f4f.

35. Kyama CM, Mwenda JM, Machoki J, Mihalyi A, Simsa P, Chai D, DXHooghe TM. Endometriosis in African

women. Women's Health 20073 3: f29 - f35.

3f. Simsa P, Mihalyi A, Kyama CM, Mwenda JM, Fulop V, DXHooghe TM. Future of endometriosis research.

Women's Health 20073 3: f47 - f54.

37. Simsa P, Mihalyi A, Kyama CM, Mwenda JM, Fulop V, DXHooghe TM. New approach in medical therapy:

Selective estrogen receptor modulators >SERMsA and aromatase inhibitors Women's Health 20073 3: f17 - f28.

38. Kyama CM, TXJampens D, Mihalyi A, Simsa P, Debrock S, Waelkens E, Landuyt B, Fulop V, Mwenda JM,

DXHooghe TM. ProteinChip technology is a useful method in the pathogenesis and diagnosis of endometriosis:

a preliminary study. Fertil Steril. 200f3 86: 203 r 209.

39. KyamaCM, Overbergh L, Debrock S, ValckM D, Vander Perre S, Meuleman C, Mihalyi A, Mathieu C, Mwenda

JM, DXHooghe TM. Increased peritoneal and endometrial gene eMpression of biologically relevant cytokines and

growth factors during menstrual phase in women with endometriosis. Fertil Steril. 200f3 85: 1ff7 r 75.

40. Mihalyi A, Simsa P, Mutinda C. Kyama, Meuleman C, Mwenda JM, DXHooghe TM. Emerging drugs in

endometriosis. Expert Opin Emerg Drugs 200f3 11: 503 r 24.

41. Kyama CM, Mihalyi A, Simsa P, Falconer H, Fulop V, Mwenda JM, Peeraer K, Meuleman C, DXHooghe TM.

Endometrial-peritoneal interactions and endometriosis. Guest Editorial. World Endometriosis Society e-JournaI.

200f3 8: 3 - 5.

42. Tomassetti C, Meuleman C, PeMsters A, Mihalyi A, KyamaC, Simsa P, DXHooghe TM. Endometriosis, recurrent

miscarriage and implantation failure: is there an immunological linko Reprod BioMed Online. 200f3 13: 70f r

712.

43. DXHooghe TM, Mihalyi AM, Simsa P, KyamaC, Peeraer K, De Loecker P, Meeuwis L, Segal L, Meuleman C. Why

We Need a Noninvasive Diagnostic Test for Minimal to Mild Endometriosis with a High Sensitivity. Editorial.

Gynecol Obstet Invest. 200f3 62: 13f - 138.

44. Falconer H, Mwenda JM, Chai DC, Wagner C, Mihalyi A, Simsa P, KyamaC3 Cornillie FJ, BergWvist A, Fried G,

DXHooghe TM. Treatment with Anti-TNF Antibody c5N reduces the eMtent of induced endometriosis in the

baboon. Hum Reprod. 200f3 21: 185f - f2.

45. Mwenda JM, Owuor AR, Kyama CM, Wango EO, MXArimi M, Langat DK. Khat >Catha edulisA up-regulates

testosterone and decreases prolactin and cortisol levels in the baboon. J Ethnopharmacol. 200f; 103:379 r

384.

4f. DXHooghe TM, Nugent N, Cuneo S, Chai D, Deer F, Debrock S, KyamaCM, Mihalyi A, Mwenda JM. Recombinant

human TNFRSF1A >r-hTBP1A inhibits the development of endometriosis in baboons: a prospective, randomided,

placebo- and drug- controlled study. Biol Reprod 200f3 74: 131 - 13f.

47. Overbergh L, KyamaCM, Debrock S, ValckM D, Mathieu C, Mwenda JM, DXHooghe TM. Validation of real-time

RT-PCR assays for mRNA Wuantification in baboons. Cytokine 20053 31: 454 r 458.

48. Kyama CM, Mwenda JM, DXHooghe TM. Animal studies. In: Sutton, Adamson bJones Eds. Modern

Management of Endometriosis: Taylor & Francis Medical Books; 2005: 41 r 49pp.

49. Mwenda JM, KyamaCM, Chai DC, Debrock S, DXHooghe TM. The baboon as an appropriate model for study of

multifactorial aspects of human endometriosis. In: S. Wolfe-Coote, Ed. The Laboratory Primate, Part II: Use of

Primate Model in Research. Elsevier books; 2005: 549 r 559pp.

50. Mihalyi A, Kyama CM, Simsa P, Debrock S, Mwenda JM, DXHooghe TM. Role of immunologic factors in the

development of endometriosis: Indications for treatment strategies. Therapy. 20053 2: f23 r f39.

51. DXHooghe TM, KyamaC, Debrock S, Meuleman C, Mwenda JM. Future directions in endometriosis research.

Ann N Y Acad Sci. 20043 1034: 31f - 325.

52. Kyama CM, DXHooghe TM, Debrock S, Machoki J, Chai DS, Mwenda JM. The prevalence of endometriosis

among African-American and African-Indigenous women. Gynecol Obstet Invest 20043 57:40 - 42.

53. DXHooghe TM, Debrock S, KyamaCM, Chai DC, Cuneo S, Hill JA, Mwenda JM. Baboon model for fundamental

and preclinical research in endometriosis. Gynecol Obstet Invest 20043 57: 43 - 4f.

54. DXHooghe TM, Hill JA, KyamaCM, Mwenda JM. A critical review of the use and application of the baboon as a

model for research in WomenXs Reproductive Health. Gynecol Obstet Inves 2004357:5-f

55. Kyama CM, Debrock S, Mwenda JM, DXHooghe TM. Potential involvement of the immune system in the

development of endometriosis. Reprod Biol Endocrinol. 20033 1:123 - 127.

5f. Mwenda JM, Arimi MM, KyamaMC, Langat DK. Effects of khat >Catha edulisA consumption on reproductive

functions: a review.East Afr Med J. 20033 80:318 - 323.

57. Mwenda JM, KyamaCM, Arimi MM, Achieng R, Langat DK. The Possible Biological Effect of Khat >Catha edulisA

EMtract On the Reproductive Functions of Male Baboons >Papio anubis). Edited by Gerhard Van Der Horst,

Daniel Franken, Riana Borman, T De Jager b Silke Dyer, Monduzi Editore 2002; 159 r 1f7pp.

58. Langat DK, Sichangi MW, Kiio M, Ochiel D, KyamaCM, Otsyula M, Mwenda JM. Evaluation of Non-Radioactive

ELISA Assay Kits for Detection of Retroviral Reverse transcriptase >RTA Activity Associated with Retroviral SIV

and HIV.Afri J Health Sci, 200138: 39 - 4f.

ABSTRACTSPRESENTEDATINTERNATIONAL/LOCALSCIENTIFICMEETINGS


Peeraer K, Tomassetti C, Gevaert O, O4eda F, De Moor B, DXHooghe TM. Proteomics analysis of plasma for early

diagnosis of endometriosis. Bestposterprize in thecategory “TranslationalResearch” awarded by EMternal

Strategic Advisory Board, a panel of f eMternal international 4ury members, during the Scientific Meeting on

December 4th 2012, KU Leuven , Dept of Development and Regeneration.

2. KyamaCM, Fassbender A, Vodoladkaia A, Mihalyi A, Simsa P, Falconer H, Lebovic DI, Mwenda JM, DXHooghe

TM. Role of cytokines in the endometrial-peritoneal cross-talk and development of endometriosis. Presented

during the Kenya Immunology Society Workshop, in Nairobi, Kenya, from 24th r 25th May 2012.

3. KyamaCM, Mihalyi A, Gevaert O, Simsa P, Waelkens E, Van de Plas R, Mwenda JM, Meuleman C, De Moor B,

DXHooghe TM. Clinical Proteomics: Evaluation of endometrial biomarkers for endometriosis. Presented during

the 4th Annual Meeting of Institute of Tropical Medicine and Infectious Diseases >ITROMIDA, in Nairobi, Kenya,

from 24th r 25th May 2012. ITROMID Abstract Book 20123 15-1f: Oral

4. KyamaCM, Falconer H, Cuneo S, Chai D, Moerman P, Mwenda JM, DXHooghe TM. Massive ectopic endometrial

necrosis occurs before development of induced endometriosis in baboons. Presented during the 4th Annual

Meeting of Institute of Tropical Medicine and Infectious Diseases >ITROMIDA, in Nairobi, Kenya, from 24th r 25th

May 2012. ITROMID Abstract Book 20123 22-23: Oral

5. Mihalyi A, Gevaert O, KyamaCM, Simsa P, Pochet N, De Smet F, De Moor B, Meuleman C, Billen J, Blanckaert

N, Vodoladkaia A, Fulop V, D'Hooghe TM. Non-Invasive diagnosis of endometriosis based on a combined

analysis of siM plasma biomarkers. Presented during the 4th Annual Meeting of Institute of Tropical Medicine

and Infectious Diseases >ITROMIDA, in Nairobi, Kenya, from 24th r 25th May 2012. ITROMID Abstract Book 20123

23-24: Oral

f. Kyama CM, Falconer H, Chai D, Mihalyi A, Cuneo S, Mwenda JM, DXHooghe TM. Menstrual endometrial

supernatant may induce stromal endometriosis in baboons. Presented during the 3fth Annual Meeting of the

Kenya Obstetrical and Gynaecological Society (KOGS), at Safari Park Hotel in Nairobi, Kenya, from 15th r 17th

February 2012. KOGS Abstract Book 2012: Oral


Peeraer K, Tomassetti C, Gevaert O, O4eda F, De Moor B, DXHooghe TM. Proteomic Analysis of Plasma for Early

Diagnosis of Endometriosis. Presented during the 3fth Annual Meeting of the Kenya Obstetrical and

Gynaecological Society (KOGS), at Safari Park Hotel in Nairobi, Kenya, from 15th r 17th February 2012. KOGS

Abstract Book 2012: Oral

8. KyamaCM, Falconer H, Cuneo S, Chai D, Moerman P, Mwenda JM, DXHooghe TM. Massive ectopic endometrial

necrosis occurs before development of induced endometriosis in baboons. Presented during the 11th World

Congress on endometriosis in Montpellier, France from September 4th to 7th, 2011. WCE Abstract Book 20113

38 - 39: FCs5-4 Oral.AwardedRodolpheMaheauxTravelgrant(KyamaCM).

9. Vodoladkaia A, Yesilyurt BT, Fassbender A, KyamaC, Bokor A, Lambrechts D, DXHooghe T. PLGF and HIF1-alpha

polymorphisms are associated with endometriosis in Caucasian women. Presented during the 11th World

Congress on endometriosis (WCE) in Montpellier, France from September 4th to 7th, 2011. WCE Abstract Book

20113 93: P1-90 Poster.

10. Fassbender A, Waelkens E, Verbeeck N, KyamaC, Bokor A, Vodoladkaia A, Meuleman C, O4eda F, De Moor B,

DXHooghe T. Plasma SELDI-TOF-MS proteomic analysis for the diagnosis of ultrasound negative endometriosis.

Presented during the 11th World Congress on endometriosis (WCE) in Montpellier, France from September 4th

to 7th, 2011. WCE Abstract Book 20113 111: P2-133 Poster.

11. De Graaff AA, DelvouM B, DXHooghe T, KyamaC, Dunselman G, Romano A. Paired-BoM gene 2 downregulation in

endometriosis correlates with low epidermal growth factor receptor level. Presented during the 11th World


20113 39 - 40: FCs5-4 Oral

12. Fassbender A, Verbeeck N, on behalf of DeMoor B, Nitsch D on behalf of Moreau Y, Kyama CM, Bokor A,

Vodoladkaia A, Meuleman C, O4eda F, Waelkens E, DXHooghe T. Combined mRNA microarray and proteomic

analysis of eutopic endometrium of women with and without endometriosis. Presented during the 11th World


20113 24: Ss9-4 Oral

13. Vodoladkaia A, El-Aalamat Y, Popovic D, KyamaC, Fassbender A, Bokor A, Meuleman C, Peeraer K, Tomassetti

C, DXHooghe T, De Moor B, Huskens D, Schols D. Panel of plasma biomarkers can predict endometriosis with

high sensitivity in patients with ultrasound negative endometriosis. Presented during the 11th World Congress

on endometriosis (WCE) in Montpellier, France from September 4th to 7th, 2011. WCE Abstract Book 20113 21:

Ss8-3 Oral

14. Lebovic DI, Yu J, DXHooghe TM, KyamaC, Bird IM, Taylor RN. PPAR-GAMMA receptor ligation reduces eutopic

endometrial nerve fiber density in baboons: A prospective, randomided, placebo-controlled study. Presented

during the 11th World Congress on endometriosis (WCE) in Montpellier, France from September 4th to 7th,

2011. WCE Abstract Book 20113 7 - 8: Ss3-2 Oral

15. Fassbender A, Overbergh L, Verdrengh E, Kyama CM, Vodoladakaia A, Bokor A, Meuleman C, Peeraer K,

Tomassetti C, Waelkens E, Mathieu C, DXHooghe TM. How can macroscopically normal peritoneum contribute

to the pathogenesis of endometriosiso Presented during the 27th Annual meeting of European Society of

Human Reproduction and Embryology (ESHRE) in Stockholm, >SwedenA from July 3rd to July fth 2011. Hum

Reprod. 20113 2f: P255- Poster

1f. KyamaCM, Mihalyi A, Gevaert O, Simsa P, Waelkens E, Van de Plas R, Mwenda JM, Meuleman C, De Moor B,

DXHooghe TM. Clinical Proteomics: Evaluation of endometrial biomarkers for endometriosis. Presented during

the University of Nairobi, College of Health Sciences 1st International Scientific Conference, in Nairobi, Kenya,

from 15th r 17th June 2011. Abstract Book 20113 20-21: Oral

17. Mihalyi A, Gevaert O, KyamaCM, Simsa P, Pochet N, De Smet F, De Moor B, Meuleman C, Billen J, Blanckaert


analysis of siM plasma biomarkers. Presented during the University of Nairobi, College of Health Sciences 1st

international Scientific Conference, in Nairobi, Kenya, from 15th r 17th June 2011. Abstract Book 20113 20: Oral

18. Fassbender A, Waelkens E, KyamaC, Bokor A, Vodoladkaia A, Verbeeck N, Van de Plas R, O4eda F, Gevaert O,

Meuleman C, Peeraer K, Tomassetti C, De Moor B, DXHooghe TM.Biomarkers in Plasma or Serum: Pitfalls in

Data Processing. Presented during the 58th Annual Scientific Meeting of the Society for Gynecologic

Investigation, Miami Beach, Florida, USA, March 1f-19, 2011.Poster

19. Kyama CM, Falconer H, Cuneo S, Chai D, Moerman P, Mwenda JM, DXHooghe TM. In vivo endometrial-

peritoneal interactions in the ontogenesis of endometriosis in baboons. Presented during the 35th Annual

Meeting of the Kenya Obstetrical and Gynaecological Society (KOGS), in Nakuru, Kenya, from 1fth r 18th

February 2011. KOGS Abstract Book 2011: Oral

20. Vodoladkaia A, Fassbender A, KyamaCM, Bokor A, ClerinM P, Gevaert O, Schols D, Huskens D, Meuleman C,

Peeraer K, Tomassetti C, De Moor B, D'Hooghe TM. Evaluation of 28 different plasma biomarkers for potential

non-invasive diagnosis of endometriosis. Oral presentation at the Dutch-Belgian Scientific Meeting of the

Vereniging voor Fertiliteitsstudie (Society for Fertility StudyA, Leuven, Belgium May 21st, 2010.

21. KyamaCM, Mihalyi A, Gevaert O, Simsa P, Waelkens E, Van de Plas R, Meuleman C, De Moor B, DXHooghe TM.

Biomarkers for endometriosis. Presented during the 18th Institute of Primate Research International Biomedical

Research Conference, in Nairobi, Kenya, from fth r 8th July 2010. Abstract Book 20103 20-21: Oral

22. DXHooghe TM, Kyama CM, Chai D, Mwenda JM. Endometriosis: Lessons from a primate model. Presented

during the 18th Institute of Primate Research International Biomedical Research Conference, in Nairobi, Kenya,

from fth r 8th July 2010. Abstract Book 20103 18: Oral

23. van Kaam K, DelvouM B, Romano A, D'Hooghe T, KyamaC, Groothuis P.EMpression of DNA methyltransferases

and methyl-CpG-binding domain proteins in human endometrium and endometriosis. Presented during the

2fth Annual meeting of European Society of Human Reproduction and Embryology (ESHRE) in Rome, >ItalyA from

June 27th to June 30th 2010. Hum Reprod. 20103 25: i2f-i28: O-0f8- Oral.


Peeraer P, Tomassetti C, De Moor B, D'Hooghe TM. Evaluation of 28 different plasma biomarkers for potential

non-invasive diagnosis of endometriosis. Presented during the 2fth Annual meeting of European Society of

Human Reproduction and Embryology (ESHRE) in Rome, >ItalyA from June 27th to June 30th 2010. Hum Reprod.

20103 25: i9-i113 O-022- Oral.

25. Fassbender A, Vodoladkaia A, Bossuy iB, KyamaM, Meuleman C, Peeraer K, Tomassetti C, DXHooghe T. Value

of plasma CRP and HSCRP levels as a biomarker for a non-invasive diagnosis of endometriosis. Presented

during the 2fth Annual meeting of European Society of Human Reproduction and Embryology (ESHRE) in Rome,

>ItalyA from June 27th to June 30th 2010. Hum Reprod. 20103 25: i210-i235. P-244.

2f. Mihalyi A, Gevaert O, KyamaCM, Simsa P, Pochet N, De Smet F, De Moor B, Meuleman C, Billen J, Blanckaert


analysis of siM plasma biomarkers. Presented during the 34th Annual Meeting of the Kenya Obstetrical and

Gynaecological Society (KOGS), in Nairobi, Kenya, from 17th r 19th February 2010. KOGS Abstract Book 20103

20-21: Oral


Peeraer K, Tomassetti C, De Moor B, D'Hooghe TM. Evaluation of 28 different plasma biomarkers for potential

non-invasive diagnosis of endometriosis. Oral presentation at the Dutch-Belgian Scientific Meeting of the

Vereniging voor Fertiliteitsstudie >Society for Fertility StudyA, Leuven, Belgium May 21st, 2010

28. DelvouM B, Groothuis P, DXHooghe TM, KyamaC, Dunselman G, Romano A. The hyper-estrogenic environment

in endometriosis lesions is the result of impaired steroid metabolism. Presented during the 25th Annual

meeting of European Society of Human Reproduction and Embryology (ESHRE) in Amsterdam, >NetherlandsA

from June 28th to July 1st 2009. Hum Reprod. 20093 24: i10 r i10. O-022- Oral.

29. Fassbender A, DXHooghe TM, Mihalyi A, KyamaC, Simsa P, Lessey B. The relationship between C3a-des-Arg and

endometriosis. Presented during the f4th Annual Meeting of the American Society for Reproductive Medicine

in San Francisco, >CA - USAA from November 8th to 12th 2008. Fertil Steril 20083 903 S143-S143. Poster

30. Bokor A, KyamaCM, Fassbender A, Vodoladkaia A, D'Hooghe T. Density of small diameter sensory nerve fibres

is endometrium: a semi-invasive diagnosis for minimal to mild endometriosis. IN TRAINING AWARD, Best

ScientificPrizePaperCandidate(BokorA). Presented during the f4th Annual Meeting of the American Society

for Reproductive Medicine in San Francisco, >CA - USAA from November 8th to 12th 2008. Fertil Steril 20083 90:

S42-S423 O-115-Oral

31. Bokor A, KyamaCM, Fassbender A, Vodoladkaia A, Vercruysse L, DXHooghe TM. tEndometrial Multiple Small

Sensory Nerve Fibers in Minimal and Mild Endometriosisu. Presented at the 20th meeting of the Belgian Society

for Reproductive Medicine, Brussels, Belgium, October 3rd 2008. Oral

32. Fassbender A, KyamaCM, Overbergh L, Debrock S, ValckM D, Vander Perre S, Meuleman C, Mihalyi A, Mwenda

JM, Mathieu C, D'Hooghe TM. Aberrant gene eMpression of cytokines in peritoneum and endometrium during

the menstrual phase in women with endometriosis. Presented during the 8th PAX Society meeting in Clermont-

Ferrand >FranceA from September 18th to 20th 2008. Oral

33. DelvouM B, DXHooghe TM, Kyama CM, Dunselman G, Groothuis P. Romano A. The high ratio of 17b-

hydroMysteroid dehydrogenase type 1 versus type 2 in endometriosis leads to a hyper-estrogenic environment

in the ectopic endometrium. Poster presentation at the 18th International Symposium of the Journal of Steroid

Biochemistry & Molecular Biology >Seefeld, Tyrol, Austria r 18-21 September 2008.

34. KyamaCM, Falconer H, Chai D, Mihalyi A Cuneo S, Mwenda JM, DXHooghe TM. Acellular menstrual fluid can

induce endometriosis in baboons. Presented during the 24th Annual meeting of European Society of Human

Reproduction and Embryology (ESHRE) in Barcelona, >SpainA from July fst to 9th 2008. Hum Reprod. 20083 23:

if5 - iff. O-1f2 Oral.

35. Fassbender A, DXHooghe T, Mihalyi A, KyamaCM, Simsa P, Lessey B. The relationship between C3a-des-Arg and

endometriosis. Oral presentation at the Dutch-Belgian Scientific Meeting of the Vereniging voor

Fertiliteitsstudie >Society for Fertility StudyA, Brussel , Belgium on fth June 2008.

3f. KyamaCM, Mihalyi A, Gevaert O, Simsa P, Waelkens E, Van de Plas R, Mwenda JM, Meuleman C, De Moor B,

DXHooghe TM. Proteomics in translational research: an integrated approach in the pathogenesis and diagnosis

of endometriosis. Presented during the 10th World Congress on endometriosis (WCE) in Melbourne, Australia

from March 11th to 14th, 2008. WCE Abstract b program Book 20083 51 - 52: Oral

37. Van Kaam K, DelvouM B, KyamaCM, Dunselman G, DXHooghe TM, Groothuis P. DNA methyltrandferase and

methyl binding domain proteins in human endometrium and endometriosis. Presented during the 10th World

Congress on endometriosis in Melbourne, Australia from March 11th to 14th, 2008. WCE Abstract b program

Book 20083 37 - 38: Oral

38. Mihalyi A, Simsa P, Kyama CM, Meuleman C Billen J, Bossuyt i, DXHooghe TM. Plasma levels of ILvf, ILv8,

TNFva, CA 125, CA 19v9 and CRP in endometriosis: Their true diagnostic potential. Presented during the 10th

World Congress on endometriosis in Melbourne, Australia from March 11th to 14th, 2008. WCE Abstract b

program Book 20083 P-371 Poster

39. DXHooghe TM, Simsa P, Mihalyi A, Schoeters G, Koppen G, Kyama CM, Den Hondt E, Fulop V. Increased

eMposure to dioMin is associated with endometriosis in women. Presented during the 10th World Congress on

endometriosis in Melbourne, Australia from March 11th to 14th, 2008. WCE Abstract b program Book 20083 38:

Oral

40. Van Kaam K, DelvouM B, Kyama CM, Dunselman G, DXHooghe TM, Groothuis P. Severe downregulation of

several genes in the eutopic endometrium of women with endometriosis is not the result of promoter

methylation. Their true diagnostic potential. Presented during the 10th World Congress on endometriosis in

Melbourne, Australia from March 11th to 14th, 2008.WCE Abstract b program Book 20083 120: P-287 Poster

41. Dassen H, Punyadeera C, Kamps R, Dunselman G, Kyama CM, DXHooghe T, Groothuis P, Romano A.

Olfactomedin 4 eMpression in human endometrium and endometriosis. Presented during the 10th World

Congress on endometriosis in Melbourne, Australia from March 11th to 14th, 2008.WCE Abstract b program

Book 20083 117: P-271 Poster

42. KyamaCM, Overbergh L, Mihalyi A, Cuneo S, Debrock S, ValckM D, Vander Perre S, Mathieu C, Mwenda JM,

DXHooghe TM. rhTBP-1 treatment effect on mRNA levels of cytokines in baboons with induced endometriosis.

Presented during the 32nd Kenya Obstetrical and Gynaecological annual Scientific meeting at Hotel

Intercontinental, Nairobi-Kenya from February 20th r 22nd, 2008. Oral


DXHooghe TM. Proteomics in translational research: an integrated approach in the pathogenesis and diagnosis

of endometriosis. Presented during the 32nd Kenya Obstetrical and Gynaecological annual Scientific meeting at

Hotel Intercontinental, Nairobi-Kenya from February 20th r 22nd , 2008. Oral

44. DXHooghe TM, KyamaCM, Chai D, Fassbender A, Bokor A, Vodoladkaia A, Mwenda JM. Nonhuman primate

models for translational research in endometriosis. Second Society of Gynecologic Investigation >SGIA

International Summit Meeting. From embryo and endometrium to implantation tThe translational researchu.

SGI Summit on Reproductive Medicine, IVI Valencia and Catedra Santiago Grisolia, Valencia, Spain, November

10th, 2007. Oral


DXHooghe TM. Evaluation of endometrial biomarkers for semi-invasive diagnosis of endometriosis. Presented

during the 23rd Annual meeting of European Society of Human Reproduction and Embryology (ESHRE) in Lyon,

>FranceA from July 1st to 4th 2007. Hum Reprod. 20073 22: i107. O-2f9 Oral.

4f. Kyama CM, Mihalyi A, Simsa P, Falconer H, Fulop V, Mwenda JM, Peeraer K, Meuleman C, DXHooghe TM.

Endometriosis is a peritoneal disease. Presented during the 7th PAX Society meeting in Leuven, >BelgiumA from

September 28th to 30th 200f. PAX Adhesions. 200f3 1f: L7-4. Oral

47. Kyama CM, Overbergh L, Mihalyi A, Meuleman C, Mwenda JM, Mathieu C, DXHooghe TM. Aberrant mRNA

eMpression of adhesion factors in women with endometriosis. Presented at the 1fth meeting of the Belgium

Society for Reproductive Medicine (BSRM) in De- Montil, Essene, >BelgiumA on October 13th 200f. Oral

presentation.

48. Kyama CM, Overbergh L, Mihalyi A, Mwenda JM, Mathieu C, DXHooghe TM. Aberrant mRNA eMpression of

adhesion factors in women with endometriosis. Presented during the 22nd Annual meeting of European Society

of Human Reproduction and Embryology (ESHRE) in PraWue, >Cdech RepublicA from June 18th to 21st 200f. Hum

Reprod. 200f3 21: i1773 P- 4f0 Poster.

49. Mihalyi A, Simsa P, KyamaCM, Meuleman C Billen J, Bossuyt i, DXHooghe TM. Plasma levels of IL-f, IL-8, TNF-

w, CA125, CA19-9 and CRP in endometriosis: their true diagnostic potential. Presented during the 53rd Annual

meeting of Society for Gynaecologic Investigation (SGI) in Toronto-Canada from March 21st to 25th 200f. J Soc

Gynecol Investig 200f3 13: Suppl 2.3 P-494 Poster

50. Mihalyi A, Kyama CM, Meuleman C, DXHooghe TM. Peritoneal and endometrial mRNA eMpression of

inflammatory cytokines and aromatase in women with and without endometriosis. Presented at the VVOG

>Flemish Society for Obstetrics and GynecologyA Herfstvergadering, October 1st, 2005. Oral

51. KyamaCM, Mihalyi A, Overbergh L, ValckM D, Meuleman C, Mathieu C, Mwenda JM, DXHooghe TM. Peritoneal

and endometrial mRNA eMpression of inflammatory cytokines and CYP19 >aromataseA in women with and

without endometriosis. Presented during the 9th World Congress on endometriosis in Maastricht >The

NetherlandsA from September 14th to 17th, 2005. Eur J Obstet Gynecol Reprod Biol. 20053 123: Suppl 13S15.

O7.4. Oral

52. KyamaCM, Overbergh L, Mihalyi A, Cuneo S, Debrock S, ValckM D, Vander Perre S, Mathieu C, Mwenda JM,

DXHooghe TM. rhTBP-1 treatment effect on mRNA levels of cytokines in baboons with induced endometriosis.

Presented during the 21st Annual meeting of European Society of Human Reproduction and Embryology

(ESHRE) in Copenhagen >DenmarkA from June 19th to 22nd 2005. Hum Reprod. 20053 20: i177-i1783 P-494 Poster

53. KyamaCM, TXJampens D, Vander Perre S, Landuyt B, Mwenda JM, DXHooghe TM. Differential protein profiling

using Ciphergen ProteinChip technology in endometrium, peritoneum and endometriotic lesions from women

with and without endometriosis. Presented during the 20th Annual meeting of European Society for Human

Reproduction and Embryology (ESHRE) in Berlin >GermanyA on June 27 -30 2004.Hum Reprod. 20043 19: i10-i12.

O-031. Oral presentation.

54. KyamaCM, Overbergh L, Debrock S, ValckM D, Vander Perre S, Mathieu C, Mwenda JM, DXHooghe TM. The

eMpression of mRNA for inflammatory cytokines is increased in the peritoneum from women with

endometriosis during the menstrual phase. Presented during the 20th Annual meeting of European Society for

Human Reproduction and Embryology (ESHRE) in Berlin >GermanyA from June 27th to 30th 2004. Hum Reprod.

2004319: i1f4-i1ff. P-488. Poster.

55. Kyama CM, DXHooghe TM, Debrock S, Machoki J, Chai DS, Mwenda JM. The prevalence of endometriosis

among African-American and African-Indigenous women. Presented at the 8th Regional meeting of the

International Society for Gynaecological Endoscopy >ISGE) from fth to 8th September 2004 at Cape Town-

South Africa. Oral presentation.AwardforthebestScientificcontribution >basic science sessionA.

5f. KyamaCM, TXJampens D, Vander Perre S, Landuyt B, Meuleman C, Mwenda JM, DXHooghe TM. CiphergenXs

ProteinChip technology is a feasible and useful method for differential protein profiling in women with and

without endometriosis. Presented at the 12th meeting of the Belgium Society for Reproductive Medicine (BSRMA

at Brussels-Belgium on October 1st 2004. Oral presentation.

57. KyamaCM, Overbergh L, Debrock S, ValckM D, Vander Perre S, Meuleman C, Mathieu C, Mwenda JM, DXHooghe

TM. Peritoneal and endometrial eMpression of mRNA for inflammatory cytokines and growth factors are

aberrantly increased during menstrual phase in women with endometriosis. Presented at the 12th meeting of

the Belgium Society for Reproductive Medicine (BSRM) at Brussels-Belgium on October 1st 2004. Oral

presentation.

58. Mwenda JM, KyamaCM, Arimi MM, Achieng R, Langat DK. The Possible Biological Effect of Khat >Catha edulisA

EMtract On the Reproductive Functions of Male Baboons >Papio anubis). Proceedings of 9th International

Symposium on Spermatology Cape Town, South Africa, October f-11, 2002. Oral

magna cum laude)€¦ · he graduated with masters degree in medical sciences >magna cum laude)...

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