Integrative approach to study the effects of cosmophysical factors on functional state of human health. International Project Khorseva N.I.1, Grigoryev P.E.2, Poskotinova L.V.3, Kilessa G.V.4, Glivenko A.V.2 1 Institute of Biochemical Physics named after N.M.Emanuel RAS, Russia, Moscow 1 Space Research Institute RAS, Russia, Moscow 2 Crimea State Medical University named after S.I.Georgievsky, Ukraine, Simferopol 3 Institute of Physiology of Natural Adaptations Ural section of RAS, Russia, Archangelsk 4National University named after V.I. Vernadsky, 95007, Ukraine, Simferopol

The aim of this work to develop the software that enables a comprehensive evaluation of the functional state of a human and assess the relationship between subjective mental state and objective psychophysiological and physiological parameters, their monitoring and comparison with environmental (cosmophysic, meteorological, ecological) and other factors.

Main components of the software complex, which enable to estimatePhasical activity of subcortical structures (hippocamp):sustainabilityof voluntary attention (correcture test)Rate of reaction on external stimuli:Simple audio-motor reactionFunctional state of motor zones and interhemispheric communication:Ten-fingers random tappingLimbic system activity: Psychoemotional state (semantic differential questionnairy)Indices of hemodynamic (SBP, DBP,HR, PP, KI)

SAMR, 1,5 minCorrecture test, 2 minrandom ten-fingers tapping, 2,5 minIndices of psycho-emotional state, 3 minHemodynamic indices, 3-5 minDatabase: more than 80 parameters for each person per session-Capability of pairwise comparison of studied parameters.-Cross-correlation matricesThe Comparison between parameters of Space weather and complex parameters, cross-correlation matrices

Structure of the functioning of local software within the framework of an information texnology universal monitoring of ecological healthExamples to the visualizations of the resultsWe have developed the information system (IS) based on the results of long-term pilot experiments and analysis of time trends of daily monitoring of psychophysiological parameters, uploaded on a web-portal www.umon.org.ua "Universal monitoring of environmental health" IS has many advantages, including: the availability and affordability, thereis no need to purchase additional devices, sensors and software. Architecture of IS makes it easy to upgrade with new modules and techniques and to expand their scope, as a basis for implementinga wide range of scientific and practical tasks per request of prospective customers and / or partners.In addition to IS, we created the separate software product called "Local Universal Monitoring" which provides a registration of additional psycho-physiological parameters as well as enhanced interpretation of the results. The recorded parameters can be transferred tothe website "Universal monitoring of environmental health" for their further processing.www.umon.org.uaGlobal Universal MonitoringLocal programLocal Universal MonitoringLUMExamples of the visualizations of the results

Examples of empirical results received from the data obtained with the software (UMON and LUM)

Latent time alterations of the simple Audio-motor reaction (SAMR) (pic ., B) and the number of delay responses (pic. )In the range of 4 days to the effect of geomagnetic disturbances (Null day).

X-direction time (days) before and after geomagnetic disturbance; Y-direction parameters of audio-motor reaction Group effectBCExamples of individual effectsSimple audio-motor reation

Variations of voluntary attention efficiency(), accuracy index (B) and the number of wrongly deleted characters(C) In relation to the dates of geomagnetic disturbances.

X-direction time (days) before and after Geomagnetic disturbances; Y-direction corresponding indices of the voluntary attentionIndices of voluntary attentionGroup effectBCExamples of individual effects

1.Presented Informational systemcan be used to assessthe health state of a manby means of rapidmethodsimplementedin the software, installed ontoa PC. The data of regular testingcan be transferredto the serverdatabase andprovides a basis for the further analysisand issueof results and recommendationsin the user interfaceonwebsitewww.umon.org.ua.The local programadditionallyimplements a number of psychophysiologicaltechniques andprovidesrapiddiagnosisof the functional stateof the subject.

2.The monitoringdataof the health state,space weatherand other factors allow fora comprehensiveanalysis ofthe health statusof the subjectwith respect to its individualstandardsfor each indicator, identifythe relationship betweenindicatorsof test and parameters ofspace weather, taking into accountthe time lagbetween them. The results obtainedare the basisfor the predictionof the human conditionin relation to the influence ofsocio-psychologicalfactorsandSpace Physics..

3.Preliminary conclusionsand recommendationsobtainedin an automated way,are the basisfor the furtherprocessingof informationby experts, physicians and otherprofessionals. The information systemhas the potentialfora variety ofresearchesbased on its technology, as well asto implement therapid diagnosisof peoplewhose professional activity is connectedto the specificrequirements fortheir health state.

General algorithm of program-client of www.umon.org.ua

2- ()

1- ()

2- ()

1- ()

-

, ,

( )

?

( )

?

( )

. ?

Spinal cord

Cerebrum

Structural components of CNS0,0167 - 0,0139 Hz-rhythm 8-12 HzCranio-sacral rhythm, micro alterations of skull and spine size are synchronized to the rhythms of cerebro-spinal fluid circulation (0,1 0,17 Hz)motoneuronsneuronssynapsesneurogliaBrain neurons

. .., .. / . - .: 1999. - 115c

****