mapping for selection signatures associated to … · 2018. 10. 2. · paulina g. eusebi1, cortés...
TRANSCRIPT
![Page 1: MAPPING FOR SELECTION SIGNATURES ASSOCIATED TO … · 2018. 10. 2. · Paulina G. Eusebi1, Cortés O.1, Dunner S.1, Cañón J.1 MAPPING FOR SELECTION SIGNATURES ASSOCIATED TO AGGRESSIVE](https://reader035.vdocuments.net/reader035/viewer/2022081410/60a01fe4eebe5e7baf5c544a/html5/thumbnails/1.jpg)
Paulina G. Eusebi1, Cortés O. 1, Dunner S.1, Cañón J.1
MAPPING FOR SELECTION SIGNATURES ASSOCIATED TO AGGRESSIVE BEHAVIOR IN
CATTLE
1 Departamento de Producción Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, Spain
69th Annual Meeting of the European Federation of
Animal Science
Dubrovnik, Croatia - 27th to 31st August 2018
![Page 2: MAPPING FOR SELECTION SIGNATURES ASSOCIATED TO … · 2018. 10. 2. · Paulina G. Eusebi1, Cortés O.1, Dunner S.1, Cañón J.1 MAPPING FOR SELECTION SIGNATURES ASSOCIATED TO AGGRESSIVE](https://reader035.vdocuments.net/reader035/viewer/2022081410/60a01fe4eebe5e7baf5c544a/html5/thumbnails/2.jpg)
INTRODUCTION
• The Lidia bovine breed has its origins 500 years ago in the Iberian Peninsula.
• This breed is selected for aggressive behavior to participate in popular festivities as part of the cultural people´s identity.
Different behavior patterns favored a fragmentation of the Spanish racial group
into lineages with low population size.
![Page 3: MAPPING FOR SELECTION SIGNATURES ASSOCIATED TO … · 2018. 10. 2. · Paulina G. Eusebi1, Cortés O.1, Dunner S.1, Cañón J.1 MAPPING FOR SELECTION SIGNATURES ASSOCIATED TO AGGRESSIVE](https://reader035.vdocuments.net/reader035/viewer/2022081410/60a01fe4eebe5e7baf5c544a/html5/thumbnails/3.jpg)
INTRODUCTION
• Lidia breed bovines were brought to Mexico in 1522. To date, the Mexican Lidia population is genetically differentiated from the Spanish lineages.
K=5
Lidia Spain Lidia Mexico
![Page 4: MAPPING FOR SELECTION SIGNATURES ASSOCIATED TO … · 2018. 10. 2. · Paulina G. Eusebi1, Cortés O.1, Dunner S.1, Cañón J.1 MAPPING FOR SELECTION SIGNATURES ASSOCIATED TO AGGRESSIVE](https://reader035.vdocuments.net/reader035/viewer/2022081410/60a01fe4eebe5e7baf5c544a/html5/thumbnails/4.jpg)
INTRODUCTION
• Genomic changes produced by selection have been studied, mainly in commercial cattle breeds.
• As a consequence, several hard-sweeps belonging to traditional selected morphological traits have been reported.
![Page 5: MAPPING FOR SELECTION SIGNATURES ASSOCIATED TO … · 2018. 10. 2. · Paulina G. Eusebi1, Cortés O.1, Dunner S.1, Cañón J.1 MAPPING FOR SELECTION SIGNATURES ASSOCIATED TO AGGRESSIVE](https://reader035.vdocuments.net/reader035/viewer/2022081410/60a01fe4eebe5e7baf5c544a/html5/thumbnails/5.jpg)
OBJECTIVES
• Locate genomic regions associated with agonistic related traits
• A marginal second objective was to identify putative candidate genes mapping within these genomic regions.
Two approaches based on the differences of allele frequencies
among populations, were applied.
![Page 6: MAPPING FOR SELECTION SIGNATURES ASSOCIATED TO … · 2018. 10. 2. · Paulina G. Eusebi1, Cortés O.1, Dunner S.1, Cañón J.1 MAPPING FOR SELECTION SIGNATURES ASSOCIATED TO AGGRESSIVE](https://reader035.vdocuments.net/reader035/viewer/2022081410/60a01fe4eebe5e7baf5c544a/html5/thumbnails/6.jpg)
MATERIAL
• 100 Spanish bovines from the most aggressive lineages.
• 65 Spanish bovines from the less aggressive lineages.
• 45 bovines from the Mexican population
genotypic 50K SNP BeadChip data
![Page 7: MAPPING FOR SELECTION SIGNATURES ASSOCIATED TO … · 2018. 10. 2. · Paulina G. Eusebi1, Cortés O.1, Dunner S.1, Cañón J.1 MAPPING FOR SELECTION SIGNATURES ASSOCIATED TO AGGRESSIVE](https://reader035.vdocuments.net/reader035/viewer/2022081410/60a01fe4eebe5e7baf5c544a/html5/thumbnails/7.jpg)
• 65 bovines from the Asturiana de los Valles breed
• 30 bovines from the Morenas Gallegas breed
MATERIAL
![Page 8: MAPPING FOR SELECTION SIGNATURES ASSOCIATED TO … · 2018. 10. 2. · Paulina G. Eusebi1, Cortés O.1, Dunner S.1, Cañón J.1 MAPPING FOR SELECTION SIGNATURES ASSOCIATED TO AGGRESSIVE](https://reader035.vdocuments.net/reader035/viewer/2022081410/60a01fe4eebe5e7baf5c544a/html5/thumbnails/8.jpg)
Selestim
• Genomic regions were built from window of ~10 MB.
• Containing each of the SNP with KLD >99.99%.
BayeScan
• Splits the FST : population-specific component (β) and locus-
specific component (α) shared by all the populations.
• Selection is detected when α is significantly different to zero.
• Genomic regions were built from a threshold of 5% FDR, and then
SNPs with α values >1.
METHODS
![Page 9: MAPPING FOR SELECTION SIGNATURES ASSOCIATED TO … · 2018. 10. 2. · Paulina G. Eusebi1, Cortés O.1, Dunner S.1, Cañón J.1 MAPPING FOR SELECTION SIGNATURES ASSOCIATED TO AGGRESSIVE](https://reader035.vdocuments.net/reader035/viewer/2022081410/60a01fe4eebe5e7baf5c544a/html5/thumbnails/9.jpg)
RESULTS BTA 3: 119.49 -119.08 Mbp
![Page 10: MAPPING FOR SELECTION SIGNATURES ASSOCIATED TO … · 2018. 10. 2. · Paulina G. Eusebi1, Cortés O.1, Dunner S.1, Cañón J.1 MAPPING FOR SELECTION SIGNATURES ASSOCIATED TO AGGRESSIVE](https://reader035.vdocuments.net/reader035/viewer/2022081410/60a01fe4eebe5e7baf5c544a/html5/thumbnails/10.jpg)
BTA 8: 14.89 -27.98 MbpRESULTS
![Page 11: MAPPING FOR SELECTION SIGNATURES ASSOCIATED TO … · 2018. 10. 2. · Paulina G. Eusebi1, Cortés O.1, Dunner S.1, Cañón J.1 MAPPING FOR SELECTION SIGNATURES ASSOCIATED TO AGGRESSIVE](https://reader035.vdocuments.net/reader035/viewer/2022081410/60a01fe4eebe5e7baf5c544a/html5/thumbnails/11.jpg)
GENES IDENTIFIED
Position (Mbp) Gene Function
109.29 GRIK3 Learning process
111.38 DLGAP3 Circadian cycles and neuronal signaling
110.17 THRAP3 Circadian cycles and behavior
111.14 SFPQ Circadian cycles and behavior
110.78 NCDN Learning and pigmentation
111.52 GJB4 Olfactory Neurophysiology
113.64 SAG Visual stimulus Neurophysiology
Position (Mbp) Gene Function
15.68 LINGO2 Neuronal disorders
17.29 PLAA Neuro-degenerative diseases
BTA 3
BTA 8
![Page 12: MAPPING FOR SELECTION SIGNATURES ASSOCIATED TO … · 2018. 10. 2. · Paulina G. Eusebi1, Cortés O.1, Dunner S.1, Cañón J.1 MAPPING FOR SELECTION SIGNATURES ASSOCIATED TO AGGRESSIVE](https://reader035.vdocuments.net/reader035/viewer/2022081410/60a01fe4eebe5e7baf5c544a/html5/thumbnails/12.jpg)
LIMITING FACTORS
• The difficulty to detect selective sweeps with statistical significance in polygenic traits, in which many loci shift their frequency moderately.
• Expected false positives due to the divergence in allelic frequencies between breeds.
• 50K chip and the sample size of the analysis
![Page 13: MAPPING FOR SELECTION SIGNATURES ASSOCIATED TO … · 2018. 10. 2. · Paulina G. Eusebi1, Cortés O.1, Dunner S.1, Cañón J.1 MAPPING FOR SELECTION SIGNATURES ASSOCIATED TO AGGRESSIVE](https://reader035.vdocuments.net/reader035/viewer/2022081410/60a01fe4eebe5e7baf5c544a/html5/thumbnails/13.jpg)
• Two genomic regions associated with agonistic related traits in cattle.
• Direction of selection of both regions differed: The “aggressive” Lidia breed and the “tamed” Asturiana de los Valles and Morenas gallegas breeds.
CONCLUSIONS
Thank you for your attention!
![Page 14: MAPPING FOR SELECTION SIGNATURES ASSOCIATED TO … · 2018. 10. 2. · Paulina G. Eusebi1, Cortés O.1, Dunner S.1, Cañón J.1 MAPPING FOR SELECTION SIGNATURES ASSOCIATED TO AGGRESSIVE](https://reader035.vdocuments.net/reader035/viewer/2022081410/60a01fe4eebe5e7baf5c544a/html5/thumbnails/14.jpg)
Paulina G. Eusebi1, Cortés O. 1, Dunner S.1, Cañón J.1
1 Departamento de Producción Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, Spain
69th Annual Meeting of the European Federation of
Animal Science
Dubrovnik, Croatia - 27th to 31st August 2018