marlies ledford-kraemer, mba, bs, mt(ascp)sh · marlies ledford-kraemer, mba, bs, mt(ascp)sh...
TRANSCRIPT
Marlies Ledford-Kraemer, MBA, BS, MT(ASCP)SH
FibrinolyticFibrinolytic PathwayPathway
Revised: mmiiiiwww.CLOT-ED.com
On Adobe toolbar, click down & choose “Fit Page” for correct viewing sizeSlide 3 provides you with a legend for all symbols used in the pathway slides that followSlide 4 shows you the entire pathway to be featured in this seriesThe remainder of the slides show you the pathway in sequential order so that you can follow each step in the process
Advance slides slowly to closely follow each additionAdvance slides quickly and you will be able to see a “cascading” effect
2
How to Use These Slides100%
Legend
3Tissue Factor Pathway InhibitorTFPI
Activated Factor VFVa
Activated FXFXa
Factor XFX
Activated Factor VIIIFVIIIa
Activated FIXFIXa
Factor IXFIX
Activated FXIFXIa
Factor XIFXI
High Molecular Weight KininogenHMWK
Activated FXIIFXIIa
Factor XIIFXII
NameSymbol
ThrombomodulinTM
“converts”, “gives rise to”, “yields”
Inhibits
Activated TAFITAFIa
Protein CPC
Plasminogen Activator Inhibitor-1PAI-1
Tissue Plasminogen ActivatortPA
Factor XIIIFXIII
Inhibited by APC
Activated Protein CAPC
Thrombin ActivatableFibrinolysis InhibitorTAFI
NameSymbol
‡
FibrinolysisFibrinolysis
FIBRINFIBRIN
Plasmin
Plasminogen
‡tPA
PAI-1FXIII
‡
Thrombin
PC APCTMThrombinProthrombin
Va
X
Xa
IX
IXa
IX
Thrombin
XIa
XI
XIIa
XII
Surface
HM
WK
Prekallikrein
Fibrinogen
VIIaTF
InjuryVessel
‡
‡ VIIIaX
TFPI
TAFI
TAFIa
Thrombin
Adapted from Broze, Semin Hematol 1992;29:159-69
ThrombinProthrombin
Va
X
Xa
IX
IXa
IX
Thrombin
XIa
XI
XIIa
XII
Surface
HM
WK
Prekallikrein
Fibrinogen
VIIaTF
InjuryVessel
‡
‡ VIIIaX
TFPI
TAFI
TAFIa
Thrombin
FIBRINFIBRIN
ThrombinProthrombin
Va
X
Xa
IX
IXa
IX
Thrombin
XIa
XI
XIIa
XII
Surface
HM
WK
Prekallikrein
Fibrinogen
VIIaTF
InjuryVessel
‡
‡ VIIIaX
TFPI
TAFI
TAFIa
Thrombin
FIBRINFIBRIN
FXIII
ThrombinProthrombin
Va
X
Xa
IX
IXa
IX
Thrombin
XIa
XI
XIIa
XII
Surface
HM
WK
Prekallikrein
Fibrinogen
VIIaTF
InjuryVessel
‡
‡ VIIIaX
TFPI
TAFI
TAFIa
Thrombin
FIBRINFIBRIN Plasminogen
FXIII
ThrombinProthrombin
Va
X
Xa
IX
IXa
IX
Thrombin
XIa
XI
XIIa
XII
Surface
HM
WK
Prekallikrein
Fibrinogen
VIIaTF
InjuryVessel
‡
‡ VIIIaX
TFPI
TAFI
TAFIa
Thrombin
FIBRINFIBRIN Plasminogen
tPAFXIII
ThrombinProthrombin
Va
X
Xa
IX
IXa
IX
Thrombin
XIa
XI
XIIa
XII
Surface
HM
WK
Prekallikrein
Fibrinogen
VIIaTF
InjuryVessel
‡
‡ VIIIaX
TFPI
TAFI
TAFIa
Thrombin
FIBRINFIBRIN
Plasmin
Plasminogen
tPAFXIII
ThrombinProthrombin
Va
X
Xa
IX
IXa
IX
Thrombin
XIa
XI
XIIa
XII
Surface
HM
WK
Prekallikrein
Fibrinogen
VIIaTF
InjuryVessel
‡
‡ VIIIaX
TFPI
TAFI
TAFIa
Thrombin
FIBRINFIBRIN
Plasmin
Plasminogen
tPAFXIII
ThrombinProthrombin
Va
X
Xa
IX
IXa
IX
Thrombin
XIa
XI
XIIa
XII
Surface
HM
WK
Prekallikrein
Fibrinogen
VIIaTF
InjuryVessel
‡
‡ VIIIaX
TFPI
TAFI
TAFIa
Thrombin
FibrinolysisFibrinolysis
FIBRINFIBRIN
Plasmin
Plasminogen
tPAFXIII
ThrombinProthrombin
Va
X
Xa
IX
IXa
IX
Thrombin
XIa
XI
XIIa
XII
Surface
HM
WK
Prekallikrein
Fibrinogen
VIIaTF
InjuryVessel
‡
‡ VIIIaX
TFPI
TAFI
TAFIa
Thrombin
FibrinolysisFibrinolysis
FIBRINFIBRIN
Plasmin
Plasminogen
tPAFXIII
ThrombinProthrombin
Va
X
Xa
IX
IXa
IX
Thrombin
XIa
XI
XIIa
XII
Surface
HM
WK
Prekallikrein
Fibrinogen
VIIaTF
InjuryVessel
‡
‡ VIIIaX
TFPI
TAFI
TAFIa
Thrombin
FibrinolysisFibrinolysis
FIBRINFIBRIN
Plasmin
Plasminogen
tPAPAI-1FXIII
ThrombinProthrombin
Va
X
Xa
IX
IXa
IX
Thrombin
XIa
XI
XIIa
XII
Surface
HM
WK
Prekallikrein
Fibrinogen
VIIaTF
InjuryVessel
‡
‡ VIIIaX
TFPI
TAFI
TAFIa
Thrombin
FibrinolysisFibrinolysis
FIBRINFIBRIN
Plasmin
Plasminogen
tPAPAI-1FXIII
‡
Thrombin
PC APCTMThrombinProthrombin
Va
X
Xa
IX
IXa
IX
Thrombin
XIa
XI
XIIa
XII
Surface
HM
WK
Prekallikrein
Fibrinogen
VIIaTF
InjuryVessel
‡
‡ VIIIaX
TFPI
TAFI
TAFIa
Thrombin
FibrinolysisFibrinolysis
FIBRINFIBRIN
Plasmin
Plasminogen
‡tPA
PAI-1FXIII
‡
Thrombin
PC APCTMThrombinProthrombin
Va
X
Xa
IX
IXa
IX
Thrombin
XIa
XI
XIIa
XII
Surface
HM
WK
Prekallikrein
Fibrinogen
VIIaTF
InjuryVessel
‡
‡ VIIIaX
TFPI
TAFI
TAFIa
Thrombin